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4. Deep learning enables accurate automatic sleep staging based on ambulatory forehead EEG

Author

Leino, A., primary, Korkalainen, H., additional, Kalevo, L., additional, Nikkonen, S., additional, Kainulainen, S., additional, Ryan, A., additional, Duce, B., additional, Sipilä, K., additional, Ahlberg, J., additional, Sahlman, J., additional, Miettinen, T., additional, Westeren-Punnonen, S., additional, Mervaala, E., additional, Töyräs, J., additional, Myllymaa, S., additional, Leppänen, T., additional, and Myllymaa, K., additional

Published
2022
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5. Preoperative Clinical Evaluation, Outline of Surgical Technique and Outcome in Temporal Lobe Epilepsy

Author

Immonen, A., Jutila, L., Kälviäinen, R., Mervaala, E., Partanen, K., Partanen, J., Vanninen, R., Ylinen, A., Alafuzoff, I., Paljärvi, L., Hurskainen, H., Rinne, J., Puranen, M., Vapalahti, M., Pickard, J. D., editor, Di Rocco, C., editor, Dolenc, V. V., editor, Fahlbusch, R., editor, Lobo Antunes, J., editor, Sindou, M., editor, de Tribolet, N., editor, Tulleken, C. A. F., editor, and Vapalahti, M., editor

Published
2004
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6. Neurobiology of Epileptogenesis in the Temporal Lobe

Author

Jutila, L., Immonen, A., Partanen, K., Partanen, J., Mervaala, E., Ylinen, A., Alafuzoff, I., Paljärvi, L., Karkola, K., Vapalahti, M., Pitkänen, A., Pickard, J. D., editor, Dolenc, V. V., editor, Antunes, J. Lobo, editor, Reulen, H.-J., editor, Sindou, M., editor, Strong, A. J., editor, de Tribolet, N., editor, Tulleken, C. A. F., editor, and Vapalahti, M., editor

Published
2002
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7. Efficacy and tolerability in patients with chronic facial pain of two consecutive treatment periods of rTMS applied over the facial motor cortex, using protocols differing in stimulation frequency, duration, and train pattern

Author

Säisänen, L. (Laura), Huttunen, J. (Jukka), Hyppönen, J. (Jelena), Nissen, M. (Mette), Kotiranta, U. (Ulla), Mervaala, E. (Esa), von und zu Fraunberg, M. (Mikael), Säisänen, L. (Laura), Huttunen, J. (Jukka), Hyppönen, J. (Jelena), Nissen, M. (Mette), Kotiranta, U. (Ulla), Mervaala, E. (Esa), and von und zu Fraunberg, M. (Mikael)

Abstract

Objective: We conducted an open-label cross-over study assessing the global effect of two high-frequency protocols of electric-field navigated repetitive transcranial magnetic stimulation (rTMS) targeted to functional facial motor cortex and comparing their efficacy and tolerability in patients with chronic facial pain. Outcome predictors were also assessed. Methods: We randomized twenty consecutive patients with chronic facial pain (post-traumatic trigeminal neuropathic pain, n=14; persistent idiopathic facial pain, n=4; secondary trigeminal neuralgia, n=2) to receive two distinct 5-day rTMS interventions (10Hz, 2400 pulses and 20Hz, 3600 pulses) separated by six weeks. The target area was assessed by mapping of lower face representation. The primary endpoint was the change in weekly mean of pain intensity (numeric rating scale, NRS) between the baseline and therapy week (1st week), and follow-up weeks (2nd and 3rd weeks) for each rTMS intervention. Response was defined using a combination scale including the patient’s global impression of change and continuance with maintenance treatment. Results: Overall, pain intensity NRS decreased from 7.4 at baseline to 5.9 ten weeks later, after the second rTMS intervention (p=0.009). The repetition of the treatment had a significant effect (F=4.983, p=0.043) indicating that the NRS scores are lower during the second four weeks period. Eight (40%) patients were responders, 4 (20%) exhibited a modest effect, 4 (20%) displayed no effect, and 4 (20%) experienced worsening of pain. High disability and high pain intensity (>7) predicted a better outcome (p=0.043 and p=0.045). Female gender, shorter duration of pain and low Beck Anxiety Inventory scores showed a trend towards a better outcome (p=0.052, 0.060 and 0.055, respectively). Conclusions: High-frequency rTMS targeted to face M1 alleviates treatment resistant chronic facial pain. Repeated treatment improves the analgesic effect. A protocol with higher frequency

Published
2022

13. Epitranscriptomics of ischemic heart disease:the IHD-EPITRAN study design and objectives

Author

Sikorski, V. (Vilbert), Karjalainen, P. (Pasi), Blokhina, D. (Daria), Oksaharju, K. (Kati), Khan, J. (Jahangir), Katayama, S. (Shintaro), Rajala, H. (Helena), Suihko, S. (Satu), Tuohinen, S. (Suvi), Teittinen, K. (Kari), Nummi, A. (Annu), Nykänen, A. (Antti), Eskin, A. (Arda), Stark, C. (Christoffer), Biancari, F. (Fausto), Kiss, J. (Jan), Simpanen, J. (Jarmo), Ropponen, J. (Jussi), Lemström, K. (Karl), Savinainen, K. (Kimmo), Lalowski, M. (Maciej), Kaarne, M. (Markku), Jormalainen, M. (Mikko), Elomaa, O. (Outi), Koivisto, P. (Pertti), Raivio, P. (Peter), Bäckström, P. (Pia), Dahlbacka, S. (Sebastian), Syrjälä, S. (Simo), Vainikka, T. (Tiina), Vähäsilta, T. (Tommi), Tuncbag, N. (Nurcan), Karelson, M. (Mati), Mervaala, E. (Eero), Juvonen, T. (Tatu), Laine, M. (Mika), Laurikka, J. (Jari), Vento, A. (Antti), Kankuri, E. (Esko), Sikorski, V. (Vilbert), Karjalainen, P. (Pasi), Blokhina, D. (Daria), Oksaharju, K. (Kati), Khan, J. (Jahangir), Katayama, S. (Shintaro), Rajala, H. (Helena), Suihko, S. (Satu), Tuohinen, S. (Suvi), Teittinen, K. (Kari), Nummi, A. (Annu), Nykänen, A. (Antti), Eskin, A. (Arda), Stark, C. (Christoffer), Biancari, F. (Fausto), Kiss, J. (Jan), Simpanen, J. (Jarmo), Ropponen, J. (Jussi), Lemström, K. (Karl), Savinainen, K. (Kimmo), Lalowski, M. (Maciej), Kaarne, M. (Markku), Jormalainen, M. (Mikko), Elomaa, O. (Outi), Koivisto, P. (Pertti), Raivio, P. (Peter), Bäckström, P. (Pia), Dahlbacka, S. (Sebastian), Syrjälä, S. (Simo), Vainikka, T. (Tiina), Vähäsilta, T. (Tommi), Tuncbag, N. (Nurcan), Karelson, M. (Mati), Mervaala, E. (Eero), Juvonen, T. (Tatu), Laine, M. (Mika), Laurikka, J. (Jari), Vento, A. (Antti), and Kankuri, E. (Esko)

Abstract

Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these modifications not only to maintain physiological processes, but also to respond to extracellular cues and various stressors. Most often, adenosine residues in RNA are targeted, and result in modifications including methylation and deamination. Such modified residues as N-6-methyl-adenosine (m⁶A) and inosine, respectively, have been associated with cardiovascular diseases, and contribute to disease pathologies. The Ischemic Heart Disease Epitranscriptomics and Biomarkers (IHD-EPITRAN) study aims to provide a more comprehensive understanding to their nature and role in cardiovascular pathology. The study hypothesis is that pathological features of IHD are mirrored in the blood epitranscriptome. The IHD-EPITRAN study focuses on m⁶A and A-to-I modifications of RNA. Patients are recruited from four cohorts: (I) patients with IHD and myocardial infarction undergoing urgent revascularization; (II) patients with stable IHD undergoing coronary artery bypass grafting; (III) controls without coronary obstructions undergoing valve replacement due to aortic stenosis and (IV) controls with healthy coronaries verified by computed tomography. The abundance and distribution of m⁶A and A-to-I modifications in blood RNA are charted by quantitative and qualitative methods. Selected other modified nucleosides as well as IHD candidate protein and metabolic biomarkers are measured for reference. The results of the IHD-EPITRAN study can be expected to enable identification of epitranscriptomic IHD biomarker candidates and potential drug targets.

Published
2021

21. Long term outcome of temporal lobe epilepsy surgery: analyses of 140 consecutive patients. (Paper)

Author

Jutila, L., Immonen, A., Mervaala, E., Partanen, J., Partanen, K., Puranen, M., Kalviainen, R., Alafuzoff, I., Hurskainen, H., Vapalahti, M., and Ylinen, A.

Subjects
Brain -- Surgery, Temporal lobe epilepsy -- Care and treatment -- Prognosis -- Patient outcomes, Health, Psychology and mental health, Care and treatment, Prognosis, Patient outcomes
Abstract

Objective: To analyse the long term results of temporal lobe epilepsy surgery in a national epilepsy surgery centre for adults, and to evaluate preoperative factors predicting a good postoperative outcome [...]

Published
2002

24. P.414 Neuronavigated and individualized alpha frequency transcranial magnetic stimulation in treatment-refractory schizophrenia

Author

Tuppurainen, H., primary, Määttä, S., additional, Könönen, M., additional, Julkunen, P., additional, Hyvärinen, S., additional, Vaurio, O., additional, Joensuu, M., additional, Vanhanen, M., additional, Aho-Mustonen, K., additional, Repo-Tiihonen, E., additional, Mervaala, E., additional, and Tiihonen, J., additional

Published
2020
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33. Polysomnographic scoring of sleep bruxism events is accurate even in the absence of video recording but unreliable with EMG-only setups

Author

Miettinen, T. (Tomi), Myllymaa, K. (Katja), Muraja-Murro, A. (Anu), Westeren-Punnonen, S. (Susanna), Hukkanen, T. (Taina), Töyräs, J. (Juha), Lappalainen, R. (Reijo), Mervaala, E. (Esa), Sipilä, K. (Kirsi), Myllymaa, S. (Sami), Miettinen, T. (Tomi), Myllymaa, K. (Katja), Muraja-Murro, A. (Anu), Westeren-Punnonen, S. (Susanna), Hukkanen, T. (Taina), Töyräs, J. (Juha), Lappalainen, R. (Reijo), Mervaala, E. (Esa), Sipilä, K. (Kirsi), and Myllymaa, S. (Sami)

Abstract

Purpose: To determine the accuracy of scoring masticatory muscle activity (MMA) events in seven different polysomnography (PSG) setups. Methods: Nineteen volunteers (13 females, 6 males, age 31.1 ± 12.9 years, 12 self-proclaimed bruxers) attended one-night PSG recording, supplemented with audio, video, and a separate frontal electroencephalography electrode set (FES). The same examiner scored the MMA events with seven different setups, with varying number of channels available: (1) one, (2) two, and (3) four EMG channels, (4) PSG without audio or video (PSG-N), (5) home PSG with FES and audio (FES-A), (6) PSG with audio (PSG-A), and (7) PSG with audio and video (PSG-AV). A subset (n = 10) of recordings was scored twice to determine intra-scorer reliability. MMA indices and accuracy of scoring the events in different setups were compared against PSG-AV. Results: The intra-class correlation coefficient (ICC) between PSG-AV and PSG-A was high (0.940, p < 0.001) as well as for FES-A (0.927, p < 0.001), whereas for PSG-N, it was lower (0.835, p < 0.001); for setups with only EMG channels, coefficients were very low (ICC < 0.100 for all). Intra-examiner reliability was high (ICC > 0.939 for all setups), with the exception of PSG-N (ICC = 0.764, p = 0.002). When comparing against the MMA events scored in PSG-AV, the sensitivity of MMA event recognition for PSG-A was 78.5% and specificity 95.5%, which were substantially higher than sensitivity (52.0%) and specificity (87.2%) of PSG-N. Conclusions: MMA event scoring accuracy with PSG-A or FES-A is almost comparable to PSG-AV. Since precise event recognition is essential for accurate MMA scoring, it is evident that one cannot rely exclusively on EMG.

Published
2019

36. Neural network analysis of nocturnal SPO2 Signal enables easy screening of sleep apnea in acute stroke and transient ischemic attack patients

Author

Leino, A., primary, Nikkonen, S., additional, Kainulainen, S., additional, Korkalainen, H., additional, Töyräs, J., additional, Myllymaa, S., additional, Leppänen, T., additional, Ylä-Herttuala, S., additional, Westeren-Punnonen, S., additional, Muraja-Murro, A., additional, Jäkälä, P., additional, Mervaala, E., additional, and Myllymaa, K., additional

Published
2019
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42. Repetitive navigated αTMS in treatment-resistant schizophrenia

Author

Tuppurainen, H., primary, Määttä, S., additional, Vanhanen, M., additional, Könönen, M., additional, Julkunen, P., additional, Aho-Mustonen, K., additional, Hyvärinen, S., additional, Vaurio, O., additional, Joensuu, M., additional, Repo-Tiihonen, E., additional, Mervaala, E., additional, and Tiihonen, J., additional

Published
2017
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43. 37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)

Author

Rob, D., primary, Špunda, R., additional, Lindner, J., additional, Šmalcová, J., additional, Šmíd, O., additional, Kovárník, T., additional, Linhart, A., additional, Bìlohlávek, J., additional, Marinoni, M. M., additional, Cianchi, G., additional, Trapani, S., additional, Migliaccio, M. L., additional, Gucci, L., additional, Bonizzoli, M., additional, Cramaro, A., additional, Cozzolino, M., additional, Valente, S., additional, Peris, A., additional, Grins, E., additional, Kort, E., additional, Weiland, M., additional, Shresta, N. Manandhar, additional, Davidson, P., additional, Algotsson, L., additional, Fitch, S., additional, Marco, G., additional, Sturgill, J., additional, Lee, S., additional, Dickinson, M., additional, Boeve, T., additional, Khaghani, A., additional, Wilton, P., additional, Jovinge, S., additional, Ahmad, A. N., additional, Loveridge, R., additional, Vlachos, S., additional, Patel, S., additional, Gelandt, E., additional, Morgan, L., additional, Butt, S., additional, Whitehorne, M., additional, Kakar, V., additional, Park, C., additional, Hayes, M., additional, Willars, C., additional, Hurst, T., additional, Best, T., additional, Vercueil, A., additional, Auzinger, G., additional, Adibelli, B., additional, Akovali, N., additional, Torgay, A., additional, Zeyneloglu, P., additional, Pirat, A., additional, Kayhan, Z., additional, Schmidbauer, S. S., additional, Herlitz, J., additional, Karlsson, T., additional, Friberg, H., additional, Knafelj, R., additional, Radsel, P., additional, Duprez, F., additional, Bonus, T., additional, Cuvelier, G., additional, Mashayekhi, S., additional, Maka, M., additional, Ollieuz, S., additional, Reychler, G., additional, Mosaddegh, R., additional, Abbasi, S., additional, Talaee, S., additional, Zotzmann, V. Z., additional, Staudacher, D. S., additional, Wengenmayer, T. W., additional, Dürschmied, D. D., additional, Bode, C. B., additional, Nelskylä, A., additional, Nurmi, J., additional, Jousi, M., additional, Schramko, A., additional, Mervaala, E., additional, Ristagno, G., additional, Skrifvars, M., additional, Ozsoy, G., additional, Kendirli, T., additional, Azapagasi, E., additional, Perk, O., additional, Gadirova, U., additional, Ozcinar, E., additional, Cakici, M., additional, Baran, C., additional, Durdu, S., additional, Uysalel, A., additional, Dogan, M., additional, Ramoglu, M., additional, Ucar, T., additional, Tutar, E., additional, Atalay, S., additional, Akar, R., additional, Kamps, M., additional, Leeuwerink, G., additional, Hofmeijer, J., additional, Hoiting, O., additional, Van der Hoeven, J., additional, Hoedemaekers, C., additional, Konkayev, A., additional, Kuklin, V., additional, Kondratyev, T., additional, Konkayeva, M., additional, Akhatov, N., additional, Sovershaev, M., additional, Tveita, T., additional, Dahl, V., additional, Wihersaari, L., additional, Skrifvars, M. B., additional, Bendel, S., additional, Kaukonen, K. M., additional, Vaahersalo, J., additional, Romppanen, J., additional, Pettilä, V., additional, Reinikainen, M., additional, Lybeck, A., additional, Cronberg, T., additional, Nielsen, N., additional, Rauber, M., additional, Steblovnik, K., additional, Jazbec, A., additional, Noc, M., additional, Kalasbail, P., additional, Garrett, F., additional, Kulstad, E., additional, Bergström, D. J., additional, Olsson, H. R., additional, Schmidbauer, S., additional, Mandel, I., additional, Mikheev, S., additional, Podoxenov, Y., additional, Suhodolo, I., additional, Podoxenov, A., additional, Svirko, J., additional, Sementsov, A., additional, Maslov, L., additional, Shipulin, V., additional, Vammen, L. V., additional, Rahbek, S. R., additional, Secher, N. S., additional, Povlsen, J. P., additional, Jessen, N. J., additional, Løfgren, B. L., additional, Granfeldt, A. G., additional, Grossestreuer, A., additional, Perman, S., additional, Patel, P., additional, Ganley, S., additional, Portmann, J., additional, Cocchi, M., additional, Donnino, M., additional, Nassar, Y., additional, Fathy, S., additional, Gaber, A., additional, Mokhtar, S., additional, Chia, Y. C., additional, Lewis-Cuthbertson, R., additional, Mustafa, K., additional, Sabra, A., additional, Evans, A., additional, Bennett, P., additional, Eertmans, W., additional, Genbrugge, C., additional, Boer, W., additional, Dens, J., additional, De Deyne, C., additional, Jans, F., additional, Skorko, A., additional, Thomas, M., additional, Casadio, M., additional, Coppo, A., additional, Vargiolu, A., additional, Villa, J., additional, Rota, M., additional, Avalli, L., additional, Citerio, G., additional, Moon, J. B., additional, Cho, J. H., additional, Park, C. W., additional, Ohk, T. G., additional, Shin, M. C., additional, Won, M. H., additional, Papamichalis, P., additional, Zisopoulou, V., additional, Dardiotis, E., additional, Karagiannis, S., additional, Papadopoulos, D., additional, Zafeiridis, T., additional, Babalis, D., additional, Skoura, A., additional, Staikos, I., additional, Komnos, A., additional, Passos, S. Silva, additional, Maeda, F., additional, Souza, L. Silva, additional, Filho, A. Amato, additional, Granjeia, T. Araújo Guerra, additional, Schweller, M., additional, Franci, D., additional, De Carvalho Filho, M., additional, Santos, T. Martins, additional, De Azevedo, P., additional, Wall, R., additional, Welters, I., additional, Tansuwannarat, P., additional, Sanguanwit, P., additional, Langer, T., additional, Carbonara, M., additional, Caccioppola, A., additional, Fusarini, C. Ferraris, additional, Carlesso, E., additional, Paradiso, E., additional, Battistini, M., additional, Cattaneo, E., additional, Zadek, F., additional, Maiavacca, R., additional, Stocchetti, N., additional, Pesenti, A., additional, Ramos, A., additional, Acharta, F., additional, Toledo, J., additional, Perezlindo, M., additional, Lovesio, L., additional, Dogliotti, A., additional, Lovesio, C., additional, Schroten, N., additional, Van der Veen, B., additional, De Vries, M. C., additional, Veenstra, J., additional, Abulhasan, Y. B., additional, Rachel, S., additional, Châtillon-Angle, M., additional, Alabdulraheem, N., additional, Schiller, I., additional, Dendukuri, N., additional, Angle, M., additional, Frenette, C., additional, Lahiri, S., additional, Schlick, K., additional, Mayer, S. A., additional, Lyden, P., additional, Akatsuka, M., additional, Arakawa, J., additional, Yamakage, M., additional, Rubio, J., additional, Mateo-Sidron, J. A. Rubio, additional, Sierra, R., additional, Celaya, M., additional, Benitez, L., additional, Alvarez-Ossorio, S., additional, Fernandez, A., additional, Gonzalez, O., additional, Engquist, H., additional, Rostami, E., additional, Enblad, P., additional, Canullo, L., additional, Nallino, J., additional, Perreault, M., additional, Talic, J., additional, Frenette, A. J., additional, Burry, L., additional, Bernard, F., additional, Williamson, D. R., additional, Adukauskiene, D., additional, Cyziute, J., additional, Adukauskaite, A., additional, Malciene, L., additional, Luca, L., additional, Rogobete, A., additional, Bedreag, O., additional, Papurica, M., additional, Sarandan, M., additional, Cradigati, C., additional, Popovici, S., additional, Vernic, C., additional, Sandesc, D., additional, Avakov, V., additional, Shakhova, I., additional, Trimmel, H., additional, Majdan, M., additional, Herzer, G. H., additional, Sokoloff, C. S., additional, Albert, M., additional, Williamson, D., additional, Odier, C., additional, Giguère, J., additional, Charbonney, E., additional, Husti, Z., additional, Kaptás, T., additional, Fülep, Z., additional, Gaál, Z., additional, Tusa, M., additional, Donnelly, J., additional, Aries, M., additional, Czosnyka, M., additional, Robba, C., additional, Liu, M., additional, Ercole, A., additional, Menon, D., additional, Hutchinson, P., additional, Smielewski, P., additional, López, R., additional, Graf, J., additional, Montes, J. M., additional, Kenawi, M., additional, Kandil, A., additional, Husein, K., additional, Samir, A., additional, Heijneman, J., additional, Huijben, J., additional, Abid-Ali, F., additional, Stolk, M., additional, Van Bommel, J., additional, Lingsma, H., additional, Van der Jagt, M., additional, Cihlar, R. C., additional, Mancino, G., additional, Bertini, P., additional, Forfori, F., additional, Guarracino, F., additional, Pavelescu, D., additional, Grintescu, I., additional, Mirea, L., additional, Alamri, S., additional, Tharwat, M., additional, Kono, N., additional, Okamoto, H., additional, Uchino, H., additional, Ikegami, T., additional, Fukuoka, T., additional, Simoes, M., additional, Trigo, E., additional, Coutinho, P., additional, Pimentel, J., additional, Franci, A., additional, Basagni, D., additional, Boddi, M., additional, Anichini, V., additional, Cecchi, A., additional, Markopoulou, D., additional, Venetsanou, K., additional, Papanikolaou, I., additional, Barkouri, T., additional, Chroni, D., additional, Alamanos, I., additional, Cingolani, E., additional, Bocci, M. G., additional, Pisapia, L., additional, Tersali, A., additional, Cutuli, S. L., additional, Fiore, V., additional, Palma, A., additional, Nardi, G., additional, Antonelli, M., additional, Coke, R., additional, Kwong, A., additional, Dwivedi, D. J., additional, Xu, M., additional, McDonald, E., additional, Marshall, J. C., additional, Fox-Robichaud, A. E., additional, Liaw, P. C., additional, Kuchynska, I., additional, Malysh, I. R., additional, Zgrzheblovska, L. V., additional, Mestdagh, L., additional, Verhoeven, E. F., additional, Hubloue, I., additional, Ruel-laliberte, J., additional, Zarychanski, R., additional, Lauzier, F., additional, Bonaventure, P. Lessard, additional, Green, R., additional, Griesdale, D., additional, Fowler, R., additional, Kramer, A., additional, Zygun, D., additional, Walsh, T., additional, Stanworth, S., additional, Léger, C., additional, Turgeon, A. F., additional, Baron, D. M., additional, Baron-Stefaniak, J., additional, Leitner, G. C., additional, Ullrich, R., additional, Tarabrin, O., additional, Mazurenko, A., additional, Potapchuk, Y., additional, Sazhyn, D., additional, Tarabrin, P., additional, Pérez, A. González, additional, Silva, J., additional, Artemenko, V., additional, Bugaev, A., additional, Tokar, I., additional, Konashevskaya, S., additional, Kolesnikova, I. M., additional, Roitman, E. V., additional, Kiss, T. Rengeiné, additional, Máthé, Z., additional, Piros, L., additional, Dinya, E., additional, Tihanyi, E., additional, Smudla, A., additional, Fazakas, J., additional, Ubbink, R., additional, Boekhorst te, P., additional, Mik, E., additional, Caneva, L., additional, Ticozzelli, G., additional, Pirrelli, S., additional, Passador, D., additional, Riccardi, F., additional, Ferrari, F., additional, Roldi, E. M., additional, Di Matteo, M., additional, Bianchi, I., additional, Iotti, G. A., additional, Zurauskaite, G., additional, Voegeli, A., additional, Meier, M., additional, Koch, D., additional, Haubitz, S., additional, Kutz, A., additional, Bargetzi, M., additional, Mueller, B., additional, Schuetz, P., additional, Von Meijenfeldt, G., additional, Van der Laan, M., additional, Zeebregts, C., additional, Christopher, K. B., additional, Vernikos, P., additional, Melissopoulou, T., additional, Kanellopoulou, G., additional, Panoutsopoulou, M., additional, Xanthis, D., additional, Kolovou, K., additional, Kypraiou, T., additional, Floros, J., additional, Broady, H., additional, Pritchett, C., additional, Marshman, M., additional, Jannaway, N., additional, Ralph, C., additional, Lehane, C. L., additional, Keyl, C. K., additional, Zimmer, E. Z., additional, Trenk, D. T., additional, Ducloy-Bouthors, A. S., additional, Jonard, M. J., additional, Fourrier, F., additional, Piza, F., additional, Correa, T., additional, Marra, A., additional, Guerra, J., additional, Rodrigues, R., additional, Vilarinho, A., additional, Aranda, V., additional, Shiramizo, S., additional, Lima, M. R., additional, Kallas, E., additional, Cavalcanti, A. B., additional, Donoso, M., additional, Vargas, P., additional, McCartney, J., additional, Ramsay, S., additional, McDowall, K., additional, Novitzky-Basso, I., additional, Wright, C., additional, Medic, M Grgic, additional, Bielen, L, additional, Radonic, V, additional, Zlopasa, O, additional, Vrdoljak, N Gubarev, additional, Gasparovic, V, additional, Radonic, R, additional, Narváez, G., additional, Cabestrero, D., additional, Rey, L., additional, Aroca, M., additional, Gallego, S., additional, Higuera, J., additional, De Pablo, R., additional, González, L. Rey, additional, Chávez, G. Narváez, additional, Lucas, J. Higuera, additional, Alonso, D. Cabestrero, additional, Ruiz, M. Aroca, additional, Valarezo, L. Jaramillo, additional, De Pablo Sánchez, R., additional, Real, A. Quinza, additional, Wigmore, T. 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Published
2017
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45. Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes

Author

University of Helsinki, Research Programs Unit, University of Helsinki, Medicum, University of Helsinki, Physiology, Nissinen, T. A., Degerman, J., Räsänen, M., Poikonen, A. R., Koskinen, S., Mervaala, E., Pasternack, A., Ritvos, O., Kivela, R., Hulmi, J. J., University of Helsinki, Research Programs Unit, University of Helsinki, Medicum, University of Helsinki, Physiology, Nissinen, T. A., Degerman, J., Räsänen, M., Poikonen, A. R., Koskinen, S., Mervaala, E., Pasternack, A., Ritvos, O., Kivela, R., and Hulmi, J. J.

Abstract

Doxorubicin is a widely used and effective chemotherapy drug. However, cardiac and skeletal muscle toxicity of doxorubicin limits its use. Inhibiting myostatin/activin signalling can prevent muscle atrophy, but its effects in chemotherapy-induced muscle wasting are unknown. In the present study we investigated the effects of doxorubicin administration alone or combined with activin receptor ligand pathway blockade by soluble activin receptor IIB (sACVR2B-Fc). Doxorubicin administration decreased body mass, muscle size and bone mineral density/content in mice. However, these effects were prevented by sACVR2B-Fc administration. Unlike in many other wasting situations, doxorubicin induced muscle atrophy without markedly increasing typical atrogenes or protein degradation pathways. Instead, doxorubicin decreased muscle protein synthesis which was completely restored by sACVR2B-Fc. Doxorubicin administration also resulted in impaired running performance without effects on skeletal muscle mitochondrial capacity/function or capillary density. Running performance and mitochondrial function were unaltered by sACVR2B-Fc administration. Tumour experiment using Lewis lung carcinoma cells demonstrated that sACVR2B-Fc decreased the cachectic effects of chemotherapy without affecting tumour growth. These results demonstrate that blocking ACVR2B signalling may be a promising strategy to counteract chemotherapy-induced muscle wasting without damage to skeletal muscle oxidative capacity or cancer treatment.

Published
2016

47. 30. Age related differences in time-varying coupling of EEG oscillations predict connectivity and excitability fluctuations in the Primary Motor Cortex: A TMS-EEG study

Author

Ferreri, F., primary, Vecchio, F., additional, Guerra, A., additional, Miraglia, F., additional, Ponzo, D., additional, Vollero, L., additional, Iannello, G., additional, Mervaala, E., additional, Maatta, S., additional, Rossini, P.M., additional, and Di Lazzaro, V., additional

Published
2016
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50. 24. Sensorimotor cortex excitability and connectivity in Alzheimer’s disease: An EEG-TMS co-registration study

Author

Guerra, A., primary, Ferreri, F., additional, Vecchio, F., additional, Vollero, L., additional, Petrichella, S., additional, Ponzo, D., additional, Määtta, S., additional, Mervaala, E., additional, Könönen, M., additional, Ursini, F., additional, Pasqualetti, P., additional, Iannello, G., additional, Rossini, P.M., additional, and Di Lazzaro, V., additional

Published
2016
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