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6 results on '"Mertins, Julius"'

1. Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors

Author

Graf, Monika, Interlandi, Marta, Moreno, Natalia, Holdhof, Dörthe, Göbel, Carolin, Melcher, Viktoria, Mertins, Julius, Albert, Thomas K., Kastrati, Dennis, Alfert, Amelie, Holsten, Till, de Faria, Flavia, Meisterernst, Michael, Rossig, Claudia, Warmuth-Metz, Monika, Nowak, Johannes, Meyer zu Hörste, Gerd, Mayère, Chloe, Nef, Serge, Johann, Pascal, Frühwald, Michael C., Dugas, Martin, Schüller, Ulrich, and Kerl, Kornelius

Published
2022
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2. ATRT-15. Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

Author

Graf, Monika, primary, Interlandi, Marta, additional, Moreno, Natalia, additional, Roy, Rajanya, additional, Holdhof, Dörthe, additional, Göbel, Carolin, additional, Melcher, Viktoria, additional, Mertins, Julius, additional, Albert, Thomas K, additional, Kastrati, Dennis, additional, Alfert, Amelie, additional, Holsten, Till, additional, de Faria, Flavia, additional, Meisterernst, Michael, additional, Rossig, Claudia, additional, Warmuth-Metz, Monika, additional, Nowak, Johannes, additional, Hörste, Gerd Meyer zu, additional, Mayère, Chloe, additional, Nef, Serge, additional, Johann, Pascal, additional, Frühwald, Michael C, additional, Dugas, Martin, additional, Schüller, Ulrich, additional, and Kerl, Kornelius, additional

Published
2022
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4. Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors

Author

Graf, Monika, Interlandi, Marta, Moreno, Natalia, Holdhof, Dörthe, Göbel, Carolin, Melcher, Viktoria, Mertins, Julius, Albert, Thomas K., Kastrati, Dennis, Alfert, Amelie, Holsten, Till, de Faria, Flavia, Meisterernst, Michael, Rossig, Claudia, Warmuth-Metz, Monika, Nowak, Johannes, Meyer zu Hörste, Gerd, Mayère, Chloe, Nef, Serge, Johann, Pascal, Frühwald, Michael C., Dugas, Martin, Schüller, Ulrich, and Kerl, Kornelius

Subjects
Mice, Germ Cells, Animals, Humans, ddc:610, SMARCB1 Protein, Single-Cell Analysis, Transcriptome, Rhabdoid Tumor
Abstract

Rhabdoid tumors (RT) are rare and highly aggressive pediatric neoplasms. Their epigenetically-driven intertumoral heterogeneity is well described; however, the cellular origin of RT remains an enigma. Here, we establish and characterize different genetically engineered mouse models driven under the control of distinct promoters and being active in early progenitor cell types with diverse embryonic onsets. From all models only Sox2-positive progenitor cells give rise to murine RT. Using single-cell analyses, we identify distinct cells of origin for the SHH and MYC subgroups of RT, rooting in early stages of embryogenesis. Intra- and extracranial MYC tumors harbor common genetic programs and potentially originate from fetal primordial germ cells (PGCs). Using PGC specific Smarcb1 knockout mouse models we validate that MYC RT originate from these progenitor cells. We uncover an epigenetic imbalance in MYC tumors compared to PGCs being sustained by epigenetically-driven subpopulations. Importantly, treatments with the DNA demethylating agent decitabine successfully impair tumor growth in vitro and in vivo. In summary, our work sheds light on the origin of RT and supports the clinical relevance of DNA methyltransferase inhibitors against this disease.

Published
2020

6. Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumorsin vitroandin vivoby targeting overexpressed Gli1

Author

Kerl, Kornelius, primary, Moreno, Natalia, additional, Holsten, Till, additional, Ahlfeld, Julia, additional, Mertins, Julius, additional, Hotfilder, Marc, additional, Kool, Marcel, additional, Bartelheim, Kerstin, additional, Schleicher, Sabine, additional, Handgretinger, Rupert, additional, Schüller, Ulrich, additional, Meisterernst, Michael, additional, and Frühwald, Michael C., additional

Published
2014
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