231 results on '"Merriman, John D."'
Search Results
2. Trajectories of fear of recurrence in women with breast cancer.
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Dunn, Laura B, Langford, Dale J, Paul, Steven M, Berman, Molly B, Shumay, Dianne M, Kober, Kord, Merriman, John D, West, Claudia, Neuhaus, John M, and Miaskowski, Christine
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Humans ,Breast Neoplasms ,Neoplasm Recurrence ,Local ,Postoperative Period ,Adaptation ,Psychological ,Fear ,Anxiety Disorders ,Quality of Life ,Middle Aged ,Survivors ,Health Services Needs and Demand ,Female ,Mind and Body ,Cancer ,Behavioral and Social Science ,Mental Health ,Clinical Research ,Patient Safety ,Breast Cancer ,7.3 Management and decision making ,7.1 Individual care needs ,Management of diseases and conditions ,Oncology ,Breast cancer ,Fear of recurrence ,Psychological symptoms ,Symptom trajectories ,Hierarchical linear modeling ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Oncology & Carcinogenesis - Abstract
PurposeAlthough fear of recurrence (FCR) is common among cancer survivors, it remains unclear what factors predict initial levels (e.g., prior to surgery) or changes in FCR in the post-treatment period. Among women treated for breast cancer, this study evaluated the effects of demographic, clinical, symptom, and psychosocial adjustment characteristics on the initial (preoperative) levels of FCR and trajectories of FCR over 6 months following surgery.MethodsPrior to and for 6 months following breast cancer surgery, 396 women were assessed for demographic and clinical (disease and treatment) characteristics, symptoms, psychological adjustment characteristics, and quality of life (QOL). FCR was assessed using a four-item subscale from the QOL instrument. Hierarchical linear modeling was used to examine changes in FCR scores and to identify predictors of inter-individual differences in preoperative FCR levels and trajectories over 6 months.ResultsFrom before surgery to 6 months post-operatively, women with breast cancer showed a high degree of inter-individual variability in FCR. Preoperatively, women who lived with someone, experienced greater changes in spiritual life, had higher state anxiety, had more difficulty coping, or experienced more distress due to diagnosis or distress to family members reported higher FCR scores. Patients who reported better overall physical health and higher FCR scores at enrollment demonstrated a steeper decrease in FCR scores over time.ConclusionsThese findings highlight inter-individual heterogeneity in initial levels and changes in FCR over time among women undergoing breast cancer surgery. Further work is needed to identify and provide interventions for women experiencing FCR during and after breast cancer treatment.
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- 2015
3. Associations between catecholaminergic, GABAergic, and serotonergic genes and self-reported attentional function in oncology patients and their family caregivers.
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Merriman, John D, Aouizerat, Bradley E, Cataldo, Janine K, Dunn, Laura B, Kober, Kord, Langford, Dale J, West, Claudia, Cooper, Bruce A, Paul, Steven M, and Miaskowski, Christine
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Humans ,Breast Neoplasms ,Catecholamines ,gamma-Aminobutyric Acid ,Serotonin Agents ,Cytokines ,Longitudinal Studies ,Family ,Attention ,Genotype ,Phenotype ,Polymorphism ,Single Nucleotide ,Aged ,Middle Aged ,Caregivers ,California ,Female ,Male ,Self Report ,Attentional function ,Cancer ,Gamma-aminobutyric acid ,Neurotransmission ,Serotonin ,Genetic Testing ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Nursing ,Oncology and Carcinogenesis - Abstract
Purpose of the researchEvaluate for associations between variations in genes involved in catecholaminergic, gamma-aminobutyric acid (GABA)-ergic, and serotonergic mechanisms of neurotransmission and attentional function latent classes.Patients and methodsThis descriptive, longitudinal study was conducted at two radiation therapy departments. The sample included three latent classes of individuals with distinct trajectories of self-reported attentional function during radiation therapy, who were previously identified using growth mixture modeling among 167 oncology patients and 85 of their family caregivers. Multivariable models were used to evaluate for genotypic associations of neurotransmission genes with attentional function latent class membership, after controlling for covariates.ResultsVariations in catecholaminergic (i.e., ADRA1D rs4815675, SLC6A3 rs37022), GABAergic (i.e., SLC6A1 rs2697138), and serotonergic (i.e., HTR2A rs2296972, rs9534496) neurotransmission genes were significant predictors of latent class membership in multivariable models.ConclusionsFindings suggest that variations in genes that encode for three distinct but related neurotransmission systems are involved in alterations in attentional function. Knowledge of both phenotypic and genetic markers associated with alterations in attentional function can be used by clinicians to identify patients and family caregivers who are at higher risk for this symptom. Increased understanding of the genetic markers associated with alterations in attentional function may provide insights into the underlying mechanisms for this significant clinical problem.
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- 2015
4. Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers.
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Miaskowski, Christine, Cataldo, Janine K, Baggott, Christina R, West, Claudia, Dunn, Laura B, Dhruva, Anand, Merriman, John D, Langford, Dale J, Kober, Kord M, Paul, Steven M, Cooper, Bruce A, and Aouizerat, Bradley E
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Humans ,Neoplasms ,Cytokines ,Severity of Illness Index ,Regression Analysis ,Anxiety ,Age Distribution ,Sex Distribution ,Genotype ,Phenotype ,Aged ,Middle Aged ,Caregivers ,Female ,Male ,Genetic Variation ,Behavioral and Social Science ,Cancer ,Genetics ,Mental Health ,Biotechnology ,2.1 Biological and endogenous factors ,Aetiology ,Radiation therapy ,Single nucleotide polymorphism ,Family caregiver ,Trait anxiety ,State anxiety ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Oncology & Carcinogenesis - Abstract
PurposeAnxiety is common among cancer patients and their family caregivers (FCs) and is associated with poorer outcomes. Recently, associations between inflammation and anxiety were identified. However, the relationship between variations in cytokine genes and anxiety warrants investigation. Therefore, phenotypic and genotypic characteristics associated with trait and state anxiety were evaluated in a sample of 167 oncology patients with breast, prostate, lung, or brain cancer and 85 of their FCs.MethodsUsing multiple regression analyses, the associations between participants' demographic and clinical characteristics as well as variations in cytokine genes and trait and state anxiety were evaluated.ResultsIn the bivariate analyses, a number of phenotypic characteristics were associated with both trait and state anxiety (e.g., age, functional status). However, some associations were specific only to trait anxiety (e.g., number of comorbid conditions) or state anxiety (e.g., participation with a FC). Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear factor kappa beta 2 (NFKB2)) were associated with trait anxiety, and variations in two genes (i.e., IL1R2, tumor necrosis factor alpha (TNFA)) were associated with state anxiety.ConclusionsThese findings suggest that both trait and state anxiety need to be assessed in oncology patients and their FCs. Furthermore, variations in cytokine genes may contribute to higher levels of anxiety in oncology patients and their FCs.
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- 2015
5. Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.
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Dhruva, Anand, Aouizerat, Bradley E, Cooper, Bruce, Paul, Steven M, Dodd, Marylin, West, Claudia, Wara, William, Lee, Kathryn, Dunn, Laura B, Langford, Dale J, Merriman, John D, Baggott, Christina, Cataldo, Janine, Ritchie, Christine, Kober, Kord M, Leutwyler, Heather, and Miaskowski, Christine
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Humans ,Neoplasms ,Fatigue ,Genetic Markers ,Cytokines ,Regression Analysis ,Haplotypes ,Phenotype ,Polymorphism ,Genetic ,Polymorphism ,Single Nucleotide ,Time ,Middle Aged ,Caregivers ,Female ,Male ,Genetic Association Studies ,breast cancer ,cytokines ,evening fatigue ,genetics ,interleukin 4 ,morning fatigue ,tumor necrosis factor alpha ,Clinical Research ,Cancer ,Genetics ,Aging ,2.1 Biological and endogenous factors ,Aetiology ,Nursing - Abstract
The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample of 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their family caregivers, growth mixture modeling was used to identify latent classes of individuals based on ratings of morning and evening fatigue obtained prior to, during, and for 4 months following completion of radiation therapy. Differences in single nucleotide polymorphisms and haplotypes in 15 cytokine genes were evaluated between the latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on morning and evening fatigue class membership. Associations were found between morning fatigue and number of comorbidities as well as variations in tumor necrosis factor alpha (TNFA) rs1800629 and rs3093662. Evening fatigue was associated with caring for children at home and variations in interleukin 4 (IL4) rs2243248 and TNFA rs2229094. Younger age and lower performance status were associated with both morning and evening fatigue. These findings suggest that inflammatory mediators are associated with the development of morning and evening fatigue. However, because different phenotypic characteristics and genomic markers are associated with diurnal variations in fatigue, morning and evening fatigue may be distinct but related symptoms.
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- 2015
6. Latent Class Analysis of Symptom Burden Among Seriously Ill Adults at the End of Life
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Murali, Komal P., Yu, Gary, Merriman, John D., Vorderstrasse, Allison, Kelley, Amy S., and Brody, Abraham A.
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- 2021
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7. Financial Toxicity in Adolescents and Young Adults With Cancer: A Concept Analysis
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Ghazal, Lauren V., Gormley, Maurade, Merriman, John D., and Santacroce, Sheila J.
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- 2021
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8. Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer
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Saad, Shanwell, Dunn, Laura B, Koetters, Theresa, Dhruva, Anand, Langford, Dale J, Merriman, John D, West, Claudia, Paul, Steven M, Cooper, Bruce, Cataldo, Janine, Hamolsky, Deborah, Elboim, Charles, Aouizerat, Bradley E, and Miaskowski, Christine
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Clinical Research ,Cancer ,Women's Health ,Depression ,Mental Illness ,Mental Health ,Brain Disorders ,Genetics ,Breast Cancer ,Adult ,Age Factors ,Aged ,Breast Neoplasms ,California ,Causality ,Comorbidity ,Female ,Genetic Predisposition to Disease ,Haplotypes ,Humans ,Interleukin-6 ,Middle Aged ,Polymorphism ,Single Nucleotide ,Receptors ,Interferon ,Socioeconomic Factors ,Tumor Necrosis Factor-alpha ,Interferon gamma Receptor ,Breast cancer ,Cytokines ,Depressive symptoms ,Subsyndromal depression ,Interleukin 6 ,Tumor necrosis factor alpha ,Interferon gamma ,Nursing ,Oncology and Carcinogenesis ,Oncology and carcinogenesis ,Health services and systems - Abstract
PurposeThis study explored the relationships between variations in cytokines genes and depressive symptoms in a sample of patients who were assessed prior to and for six months following breast cancer surgery. Phenotypic differences between Resilient (n = 155) and Subsyndromal (n = 180) depressive symptom classes, as well as variations in cytokine genes were evaluated.MethodPatients were recruited prior to surgery and followed for six months. Growth mixture modeling was used to identify distinct latent classes based on Center for Epidemiological Studies Depression (CES-D) Scale scores. Eighty-two single nucleotide polymorphisms and 35 haplotypes among 15 candidate cytokine genes were evaluated.ResultsPatients in the Subsyndromal class were significantly younger, more likely to be married or partnered, and reported a significantly lower functional status. Variation in three cytokine genes (i.e., interferon gamma receptor 1 (IFNGR1 rs9376268), interleukin 6 (IL6 rs2069840), tumor necrosis factor alpha (TNFA rs1799964)), as well as age and functional status predicted membership in the Subsyndromal versus the Resilient class.ConclusionsA variation in TNFA that was associated with Subsyndromal depressive symptoms in a sample of patients and their family caregivers was confirmed in this sample. Variations in cytokine genes may place these patients at higher risk for the development of Subsyndromal levels of depressive symptoms.
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- 2014
9. Identification of patient subgroups and risk factors for persistent arm/shoulder pain following breast cancer surgery
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Miaskowski, Christine, Paul, Steven M, Cooper, Bruce, West, Claudia, Levine, Jon D, Elboim, Charles, Hamolsky, Deborah, Abrams, Gary, Luce, Judith, Dhruva, Anand, Langford, Dale J, Merriman, John D, Kober, Kord, Baggott, Christina, Leutwyler, Heather, and Aouizerat, Bradley E
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Health Services and Systems ,Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Breast Cancer ,Clinical Research ,Patient Safety ,Cancer ,Chronic Pain ,Pain Research ,Rehabilitation ,Musculoskeletal ,Activities of Daily Living ,Arm ,Breast Neoplasms ,California ,Female ,Hand Strength ,Humans ,Longitudinal Studies ,Mastectomy ,Middle Aged ,Pain Measurement ,Pain ,Postoperative ,Prevalence ,Prospective Studies ,Quality of Life ,Range of Motion ,Articular ,Risk Factors ,Shoulder Pain ,Surveys and Questionnaires ,Arm pain ,Shoulder pain ,Persistent postsurgical pain ,Risk factors ,Breast cancer surgery ,Growth mixture modeling ,Latent class analysis ,Chronic pain ,Nursing ,Oncology and Carcinogenesis ,Oncology and carcinogenesis ,Health services and systems - Abstract
PurposeIn this prospective, longitudinal study, we extend our findings on persistent breast pain in patients (n = 398) following breast cancer surgery and evaluate the prevalence and characteristics of persistent pain in the arm/shoulder. In addition, differences in the severity of common symptoms and quality of life outcomes measured prior to surgery, among the arm pain classes, were evaluated.Methods and samplePatients were recruited from Breast Care Centers located in a Comprehensive Cancer Center, two public hospitals, and four community practices. Patients were assessed prior to and monthly for six months following breast cancer surgery.ResultsUsing growth mixture modeling, patients were classified into no (41.6%), mild (23.6%), and moderate (34.8%) arm pain classes based on ratings of worst arm/shoulder pain. Compared to the no pain class, patients in the moderate pain class were significantly younger, had a higher body mass index, and were more likely to report preoperative breast pain and swelling in the affected breast. In addition, patients in the moderate pain class reported higher levels of depression, anxiety, and sleep disturbance than the no pain class.ConclusionsFindings suggest that approximately 35% of women experience persistent levels of moderate arm/shoulder pain in the first six months following breast cancer surgery. Moderate arm/shoulder pain is associated with clinically meaningful decrements in functional status and quality of life.
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- 2014
10. Differences in the symptom experience of older oncology outpatients.
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Ritchie, Christine, Dunn, Laura B, Paul, Steven M, Cooper, Bruce A, Skerman, Helen, Merriman, John D, Aouizerat, Bradley, Alexander, Kimberly, Yates, Patsy, Cataldo, Janine, and Miaskowski, Christine
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Humans ,Neoplasms ,Severity of Illness Index ,Prevalence ,Longitudinal Studies ,Prospective Studies ,Age Factors ,Aged ,Middle Aged ,Outpatients ,United States ,Australia ,Female ,Male ,Geriatric oncology ,cancer ,multiple concurrent symptoms ,symptom assessment ,symptom distress ,symptoms ,Clinical Research ,Mind and Body ,Aging ,Clinical Trials and Supportive Activities ,Digestive Diseases ,Cancer ,Medical and Health Sciences ,Anesthesiology - Abstract
ContextThe relatively low number of older patients in cancer trials limits knowledge of how older adults experience symptoms associated with cancer and its treatment.ObjectivesThis study evaluated for differences in the symptom experience across four older age groups (60-64, 65-69, 70-74, ≥75 years).MethodsDemographic, clinical, and symptom data from 330 patients aged >60 years who participated in one Australian and two U.S. studies were evaluated. The Memorial Symptom Assessment Scale was used to evaluate the occurrence, severity, frequency, and distress of 32 symptoms commonly associated with cancer and its treatment.ResultsOn average, regardless of the age group, patients reported 10 concurrent symptoms. The most prevalent symptoms were physical in nature. Worrying was the most common psychological symptom. For 28 (87.5%) of the 32 Memorial Symptom Assessment Scale symptoms, no age-related differences were found in symptom occurrence rates. For symptom severity ratings, an age-related trend was found for difficulty swallowing. As age increased, severity of difficulty swallowing decreased. For symptom frequency, age-related trends were found for feeling irritable and diarrhea, with both decreasing in frequency as age increased. For symptom distress, age-related trends were found for lack of energy, shortness of breath, feeling bloated, and difficulty swallowing. As age increased, these symptoms received lower average distress ratings.ConclusionAdditional research is warranted to examine how age differences in symptom experience are influenced by treatment differences, aging-related changes in biological or psychological processes, or age-related response shift.
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- 2014
11. Preliminary evidence of an association between an interleukin 6 promoter polymorphism and self-reported attentional function in oncology patients and their family caregivers.
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Merriman, John D, Aouizerat, Bradley E, Langford, Dale J, Cooper, Bruce A, Baggott, Christina R, Cataldo, Janine K, Dhruva, Anand, Dunn, Laura, West, Claudia, Paul, Steven M, Ritchie, Christine S, Swift, Patrick S, and Miaskowski, Christine
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Humans ,Neoplasms ,Interleukin-6 ,Family ,Attention ,Polymorphism ,Single Nucleotide ,Aged ,Middle Aged ,Caregivers ,Female ,Male ,Promoter Regions ,Genetic ,attention ,cancer ,cytokines ,genetic association studies ,inflammation ,radiotherapy ,Genetics ,Cancer ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Nursing - Abstract
Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare "G" allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.
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- 2014
12. Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery.
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Langford, Dale J, West, Claudia, Elboim, Charles, Cooper, Bruce A, Abrams, Gary, Paul, Steven M, Schmidt, Brian L, Levine, Jon D, Merriman, John D, Dhruva, Anand, Neuhaus, John, Leutwyler, Heather, Baggott, Christina, Sullivan, Carmen Ward, Aouizerat, Bradley E, and Miaskowski, Christine
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Humans ,Breast Neoplasms ,Pain ,Genetic Predisposition to Disease ,Potassium Channels ,Regression Analysis ,Genotype ,Polymorphism ,Single Nucleotide ,Adult ,Aged ,Middle Aged ,Female ,Young Adult ,Genetic Association Studies ,breast cancer ,breast pain ,candidate genes ,potassium channel genes ,preoperative pain ,Genetics ,Neurosciences ,Genetic Testing ,Pain Research ,Patient Safety ,Breast Cancer ,Clinical Research ,Cancer ,Chronic Pain ,Aetiology ,2.1 Biological and endogenous factors ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Preoperative breast pain in women with breast cancer may result from a number of causes. Previous work from our team found that breast pain occurred in 28.2% of women (n = 398) who were about to undergo breast cancer surgery. The occurrence of preoperative breast pain was associated with a number of demographic and clinical characteristics, as well as variation in two cytokine genes. Given that ion channels regulate excitability of sensory neurons, we hypothesized that variations in potassium channel genes would be associated with preoperative breast pain in these patients. Therefore, in this study, we evaluated for associations between single-nucleotide polymorphisms and inferred haplotypes among 10 potassium channel genes and the occurrence of preoperative breast pain in patients scheduled to undergo breast cancer surgery. Multivariable logistic regression analyses were used to identify those genetic variations that were associated with the occurrence of preoperative breast pain while controlling for age and genomic estimates of and self-reported race/ethnicity. Variations in four potassium channel genes: (1) potassium voltage-gated channel, delayed rectifier, subfamily S, member 1 (KCNS1); (2) potassium inwardly rectifying channel, subfamily J, member 3 (KCNJ3); (3) KCNJ6; and (4) potassium channel, subfamily K, member 9 (KCNK9) were associated with the occurrence of breast pain. Findings from this study warrant replication in an independent sample of women who report breast pain following one or more breast biopsies.
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- 2014
13. Association between an interleukin 1 receptor, type I promoter polymorphism and self-reported attentional function in women with breast cancer
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Merriman, John D, Aouizerat, Bradley E, Cataldo, Janine K, Dunn, Laura, Cooper, Bruce A, West, Claudia, Paul, Steven M, Baggott, Christina R, Dhruva, Anand, Kober, Kord, Langford, Dale J, Leutwyler, Heather, Ritchie, Christine S, Abrams, Gary, Dodd, Marylin, Elboim, Charles, Hamolsky, Deborah, Melisko, Michelle, and Miaskowski, Christine
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Biomedical and Clinical Sciences ,Immunology ,Clinical Research ,Genetics ,Women's Health ,Cancer ,Aging ,Breast Cancer ,Behavioral and Social Science ,Aetiology ,2.1 Biological and endogenous factors ,Alleles ,Attention ,Breast Neoplasms ,Demography ,Female ,Genetic Association Studies ,Genetic Predisposition to Disease ,Heterozygote ,Homozygote ,Humans ,Logistic Models ,Middle Aged ,Models ,Biological ,Phenotype ,Polymorphism ,Single Nucleotide ,Promoter Regions ,Genetic ,Receptors ,Interleukin-1 Type I ,Self Report ,Breast cancer ,Inflammation ,Cytokine genes ,Interleukin 1 receptor ,type I ,AFI ,AIMs ,Attentional Function Index ,BIC ,BLRT ,BMI ,Bayesian information criterion ,CI ,CNS ,DNA ,GMM ,KPS ,Karnofsky Performance Status ,LD ,MAF ,OR ,SCQ ,SNP ,Self-administered Comorbidity Questionnaire ,VLMR ,Vuong-Lo-Mendell-Rubin likelihood ratio test ,ancestry informative markers ,body mass index ,bootstrapped likelihood ratio test ,central nervous system ,confidence interval ,deoxyribonucleic acid ,growth mixture modeling ,linkage disequilibrium ,minor allele frequency ,odds ratio ,single nucleotide polymorphism ,Biochemistry and Cell Biology - Abstract
Subgroups of patients with breast cancer may be at greater risk for cytokine-induced changes in cognitive function after diagnosis and during treatment. The purposes of this study were to identify subgroups of patients with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) predictors of subgroup membership. Self-reported attentional function was evaluated in 397 patients with breast cancer using the Attentional Function Index before surgery and for six months after surgery (i.e., seven time points). Using growth mixture modeling, three attentional function latent classes were identified: High (41.6%), Moderate (25.4%), and Low-moderate (33.0%). Patients in the Low-moderate class were significantly younger than those in the High class, with more comorbidities and lower functional status than the other two classes. No differences were found among the classes in years of education, race/ethnicity, or other clinical characteristics. DNA was recovered from 302 patients' samples. Eighty-two single nucleotide polymorphisms among 15 candidate genes were included in the genetic association analyses. After controlling for age, comorbidities, functional status, and population stratification due to race/ethnicity, IL1R1 rs949963 remained a significant genotypic predictor of class membership in the multivariable model. Carrying the rare "A" allele (i.e., GA+AA) was associated with a twofold increase in the odds of belonging to a lower attentional function class (OR: 1.98; 95% CI: 1.18, 3.30; p=.009). Findings provide evidence of subgroups of women with breast cancer who report distinct trajectories of attentional function and of a genetic association between subgroup membership and an IL1R1 promoter polymorphism.
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- 2014
14. Associations Between Cytokine Gene Variations and Severe Persistent Breast Pain in Women Following Breast Cancer Surgery
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Stephens, Kimberly, Cooper, Bruce A, West, Claudia, Paul, Steven M, Baggott, Christina R, Merriman, John D, Dhruva, Anand, Kober, Kord M, Langford, Dale J, Leutwyler, Heather, Luce, Judith A, Schmidt, Brian L, Abrams, Gary M, Elboim, Charles, Hamolsky, Deborah, Levine, Jon D, Miaskowski, Christine, and Aouizerat, Bradley E
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Health Sciences ,Cancer ,Chronic Pain ,Breast Cancer ,Genetics ,Pain Research ,Aetiology ,2.1 Biological and endogenous factors ,Breast ,Breast Neoplasms ,Cytokines ,Female ,Genotyping Techniques ,Haplotypes ,Humans ,Interleukin-10 ,Linkage Disequilibrium ,Logistic Models ,Longitudinal Studies ,Mastectomy ,Middle Aged ,Pain Measurement ,Pain ,Postoperative ,Phenotype ,Polymorphism ,Single Nucleotide ,Receptors ,Interleukin-1 Type II ,Severity of Illness Index ,Surveys and Questionnaires ,polymorphism ,breast cancer surgery ,candidate genes ,persistent pain ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Anesthesiology ,Clinical sciences ,Epidemiology - Abstract
UnlabelledPersistent pain following breast cancer surgery is a significant clinical problem. Although immune mechanisms may play a role in the development and maintenance of persistent pain, few studies have evaluated for associations between persistent breast pain following breast cancer surgery and variations in cytokine genes. In this study, associations between previously identified extreme persistent breast pain phenotypes (ie, no pain vs severe pain) and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated. In unadjusted analyses, the frequency of 13 SNPs and 3 haplotypes in 7 genes differed significantly between the no pain and severe pain classes. After adjustment for preoperative breast pain and the severity of average postoperative pain, 1 SNP (ie, interleukin [IL] 1 receptor 2 rs11674595) and 1 haplotype (ie, IL10 haplotype A8) were associated with pain group membership. These findings suggest a role for cytokine gene polymorphisms in the development of persistent breast pain following breast cancer surgery.PerspectiveThis study evaluated for associations between cytokine gene variations and the severity of persistent breast pain in women following breast cancer surgery. Variations in 2 cytokine genes were associated with severe breast pain. The results suggest that cytokines play a role in the development of persistent postsurgical pain.
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- 2014
15. Associations between cytokine gene variations and self-reported sleep disturbance in women following breast cancer surgery.
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Alfaro, Emely, Dhruva, Anand, Langford, Dale J, Koetters, Theresa, Merriman, John D, West, Claudia, Dunn, Laura B, Paul, Steven M, Cooper, Bruce, Cataldo, Janine, Hamolsky, Deborah, Elboim, Charles, Kober, Kord, Aouizerat, Bradley E, and Miaskowski, Christine
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Humans ,Breast Neoplasms ,Interleukin-6 ,Cytokines ,Preoperative Care ,Incidence ,Multivariate Analysis ,Logistic Models ,Risk Assessment ,Longitudinal Studies ,Age Distribution ,Phenotype ,Polymorphism ,Single Nucleotide ,Adult ,Aged ,Middle Aged ,Female ,NF-kappa B p52 Subunit ,Genetic Variation ,Self Report ,Surveys and Questionnaires ,Sleep Wake Disorders ,Breast cancer ,Cytokine genes ,Growth mixture modeling ,Insomnia ,Sleep disturbance ,Symptom trajectories ,Nursing ,Oncology and Carcinogenesis - Abstract
Purpose of the researchTo attempt to replicate the associations found in our previous study of patients and family caregivers between interleukin 6 (IL6) and nuclear factor kappa beta 2 (NFKB2) and sleep disturbance and to identify additional genetic associations in a larger sample of patients with breast cancer.Methods and samplePatients with breast cancer (n = 398) were recruited prior to surgery and followed for six months. Patients completed a self-report measure of sleep disturbance and provided a blood sample for genomic analyses. Growth mixture modeling was used to identify distinct latent classes of patients with higher and lower levels of sleep disturbance.Key resultsPatients who were younger and who had higher comorbidity and lower functional status were more likely to be in the high sustained sleep disturbance class. Variations in three cytokine genes (i.e., IL1 receptor 2 (IL1R2), IL13, NFKB2) predicted latent class membership.ConclusionsPolymorphisms in cytokine genes may partially explain inter-individual variability in sleep disturbance. Determination of high risk phenotypes and associated molecular markers may allow for earlier identification of patients at higher risk for developing sleep disturbance and lead to the development of more targeted clinical interventions.
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- 2014
16. Differences in morning and evening fatigue in oncology patients and their family caregivers.
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Dhruva, Anand, Aouizerat, Bradley E, Cooper, Bruce, Paul, Steven M, Dodd, Marylin, West, Claudia, Wara, William, Lee, Kathryn, Dunn, Laura B, Langford, Dale J, Merriman, John D, Baggott, Christina, Cataldo, Janine, Ritchie, Christine, Kober, Kord, Leutwyler, Heather, and Miaskowski, Christine
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Humans ,Neoplasms ,Fatigue ,Ambulatory Care ,Severity of Illness Index ,Analysis of Variance ,Risk Assessment ,Chi-Square Distribution ,Longitudinal Studies ,Age Factors ,Sex Factors ,Circadian Rhythm ,Adult ,Aged ,Middle Aged ,Caregivers ,Ambulatory Care Facilities ,Cancer Care Facilities ,Female ,Male ,Cancer treatment ,Diurnal variability ,Evening fatigue ,Growth mixture modeling ,Latent class analysis ,Morning fatigue ,Radiation therapy ,Cancer ,Nursing ,Oncology and Carcinogenesis - Abstract
Purpose of the researchTo identify distinct latent classes of individuals based on ratings of morning and evening fatigue; evaluate for differences in phenotypic characteristics, as well as symptom and quality of life scores, among these latent classes; and evaluate for an overlap in morning and evening fatigue class membership.Patients and methodsIn a sample of 167 oncology outpatients and 85 of their FCs, growth mixture modeling was used to identify distinct latent classes based on ratings of morning and evening fatigue obtained before, during, and after radiation therapy. Analyses of variance and Chi Square analyses were used to evaluate for differences among the morning and evening fatigue latent classes.ResultsThree distinct latent classes for morning fatigue were identified. Participants in the High Morning Fatigue class (47%) were younger and had lower functional status. Three distinct latent classes for evening fatigue were identified. Participants in the High Evening Fatigue class (61%) were younger, more likely to be female, more likely to have children at home, and more likely to be a FC. Only 10.3% of participants were classified in both the Very Low Morning and Low Evening Fatigue classes and 41.3% were classified in both the High Morning and High Evening Fatigue classes.ConclusionsDifferent characteristics were associated with morning and evening fatigue, which suggests that morning and evening fatigue may be distinct but related symptoms. Additional research is needed to elucidate the mechanisms that may underlie diurnal variability in fatigue.
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- 2013
17. Proposed mechanisms for cancer- and treatment-related cognitive changes.
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Merriman, John D, Von Ah, Diane, Miaskowski, Christine, and Aouizerat, Bradley E
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Humans ,Neoplasms ,Antineoplastic Agents ,Cognition ,cancer ,cytokines ,inflammation ,neurotransmitters ,Hematology ,Behavioral and Social Science ,Cancer ,Genetics ,Clinical Research ,Neurosciences ,Mind and Body ,Aetiology ,2.1 Biological and endogenous factors ,Nursing ,Oncology and Carcinogenesis - Abstract
ObjectivesTo review the proposed mechanisms of cognitive changes associated with non-central nervous system cancers and cancer treatment.Data sourcesReview and synthesis of databased publications and review articles.ConclusionProposed mechanisms include cytokine upregulation, hormonal changes, neurotransmitter dysregulation, attentional fatigue, genetic predisposition, and comorbid symptoms.Implications for nursing practiceOncology nurses need to understand the multiple mechanisms that may contribute to the development of cancer- and treatment-related cognitive changes so that they can identify patients at high risk and help patients understand why these changes occur.
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- 2013
18. Assessment and Management of Cancer- and Cancer Treatment–Related Cognitive Impairment
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Allen, Deborah H., Myers, Jamie S., Jansen, Catherine E., Merriman, John D., and Von Ah, Diane
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- 2018
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19. Cytokine gene variation is associated with depressive symptom trajectories in oncology patients and family caregivers.
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Dunn, Laura B, Aouizerat, Bradley E, Langford, Dale J, Cooper, Bruce A, Dhruva, Anand, Cataldo, Janine K, Baggott, Christina R, Merriman, John D, Dodd, Marylin, West, Claudia, Paul, Steven M, and Miaskowski, Christine
- Subjects
Humans ,Neoplasms ,Genetic Predisposition to Disease ,Cytokines ,Severity of Illness Index ,Incidence ,Multivariate Analysis ,Logistic Models ,Cohort Studies ,Follow-Up Studies ,Depression ,Medical Oncology ,Comorbidity ,Age Distribution ,Sex Distribution ,Genotype ,Phenotype ,Polymorphism ,Single Nucleotide ,Adult ,Aged ,Middle Aged ,Caregivers ,California ,Female ,Male ,Genetic Variation ,Clinical Research ,Breast Cancer ,Mind and Body ,Genetics ,Mental Health ,Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Growth mixture modeling ,Family caregivers ,Radiation therapy ,Nursing ,Oncology and Carcinogenesis - Abstract
PurposeDepressive symptoms are common in cancer patients and their family caregivers (FCs). While these symptoms are characterized by substantial interindividual variability, the factors that predict this variability remain largely unknown. This study sought to confirm latent classes of oncology patients and FCs with distinct depressive symptom trajectories and to examine differences in phenotypic and genotypic characteristics among these classes.MethodAmong 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their FCs, growth mixture modeling (GMM) was used to identify latent classes of individuals based on Center for Epidemiological Studies-Depression (CES-D) scores obtained prior to, during, and for four months following completion of radiation therapy. One hundred four single nucleotide polymorphisms (SNPs) and haplotypes in 15 candidate cytokine genes were interrogated for differences between the two largest latent classes. Multivariate logistic regression analyses assessed effects of phenotypic and genotypic characteristics on class membership.ResultsFour latent classes were confirmed: Resilient (56.3%), Subsyndromal (32.5%), Delayed (5.2%), and Peak (6.0%). Participants who were younger, female, non-white, and who reported higher baseline trait and state anxiety were more likely to be in the Subsyndromal, Delayed, or Peak groups. Variation in three cytokine genes (i.e., interleukin 1 receptor 2 [IL1R2], IL10, tumor necrosis factor alpha [TNFA]), age, and performance status predicted membership in the Resilient versus Subsyndromal classes.ConclusionsFindings confirm the four latent classes of depressive symptom trajectories previously identified in a sample of breast cancer patients. Variations in cytokine genes may influence variability in depressive symptom trajectories.
- Published
- 2013
20. Evidence of associations between cytokine genes and subjective reports of sleep disturbance in oncology patients and their family caregivers.
- Author
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Miaskowski, Christine, Cooper, Bruce A, Dhruva, Anand, Dunn, Laura B, Langford, Dale J, Cataldo, Janine K, Baggott, Christina R, Merriman, John D, Dodd, Marylin, Lee, Kathryn, West, Claudia, Paul, Steven M, and Aouizerat, Bradley E
- Subjects
Humans ,Neoplasms ,Cytokines ,Models ,Statistical ,Regression Analysis ,Polymorphism ,Single Nucleotide ,Middle Aged ,Caregivers ,Female ,Male ,Self Report ,Sleep Wake Disorders ,Sleep Research ,Genetics ,Cancer ,Aetiology ,2.1 Biological and endogenous factors ,General Science & Technology - Abstract
The purposes of this study were to identify distinct latent classes of individuals based on subjective reports of sleep disturbance; to examine differences in demographic, clinical, and symptom characteristics between the latent classes; and to evaluate for variations in pro- and anti-inflammatory cytokine genes between the latent classes. Among 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their FCs, growth mixture modeling (GMM) was used to identify latent classes of individuals based on General Sleep Disturbance Scale (GSDS) obtained prior to, during, and for four months following completion of radiation therapy. Single nucleotide polymorphisms (SNPs) and haplotypes in candidate cytokine genes were interrogated for differences between the two latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on GSDS group membership. Two latent classes were identified: lower sleep disturbance (88.5%) and higher sleep disturbance (11.5%). Participants who were younger and had a lower Karnofsky Performance status score were more likely to be in the higher sleep disturbance class. Variation in two cytokine genes (i.e., IL6, NFKB) predicted latent class membership. Evidence was found for latent classes with distinct sleep disturbance trajectories. Unique genetic markers in cytokine genes may partially explain the interindividual heterogeneity characterizing these trajectories.
- Published
- 2012
21. Complex Care Needs at the End of Life for Seriously Ill Adults With Multiple Chronic Conditions
- Author
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Murali, Komal Patel, primary, Merriman, John D., additional, Yu, Gary, additional, Vorderstrasse, Allison, additional, Kelley, Amy S., additional, and Brody, Abraham A., additional
- Published
- 2023
- Full Text
- View/download PDF
22. Community Navigation and Supportive Care Experiences of Low-Income Black and Latina Cancer Survivors: Patient and Navigator Perspectives
- Author
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Mazor, Melissa, David, Daniel, Moorehead, Dolores, Merriman, John D., and Lin, Jenny J.
- Subjects
Article - Abstract
BACKGROUND: Little is known about the role of community-based navigation in supportive care delivery for historically marginalized cancer survivors. The purposes of this study were to evaluate supportive care experiences of low-income, Black and Latina cancer survivors and examine the care role of their community navigator. METHODS: Qualitative evaluation of semi-structured interviews with Black and Latina cancer survivors (n=10) and navigators (n=4) from a community-based organization for low-income women were conducted and analyzed using content analysis. RESULTS: Content analysis yielded six themes that described the supportive care experience over time and before and after navigator support. Navigating supportive care alone: a) internal and external influencers; b) alone and just surviving; c) feeling overwhelmed and distressed. Community Navigator delivered supportive care: a) establishing trust and safety; b) accepting multi-dimensional, navigator assisted supportive care management; c) distress alleviation. CONCLUSIONS: Low-income Black and Latina women with cancer reported internal strength yet endured cancer care alone leading to a feeling of distress. Subsequently, community navigators provided patient-centric, supportive care and alleviate physical and emotional distress. These findings highlight the importance of increasing awareness of and linkage to community navigators who may be able to meet the supportive care needs of diverse patient populations.
- Published
- 2023
23. Profiles of Work and Quality of Life among Young Adult Cancer Survivors
- Author
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Ghazal, Lauren V., primary, Merriman, John D., additional, Santacroce, Sheila J., additional, Fletcher, Jason, additional, Wright, Fay, additional, and Dickson, Victoria Vaughan, additional
- Published
- 2022
- Full Text
- View/download PDF
24. Exploration of Relationships Between Symptoms, Work Characteristics, and Quality of Life in Young Adult Hematologic Cancer Survivors
- Author
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Ghazal, Lauren V., primary, Merriman, John D., additional, Santacroce, Sheila J., additional, Fletcher, Jason, additional, Wright, Fay, additional, and Dickson, Victoria Vaughan, additional
- Published
- 2022
- Full Text
- View/download PDF
25. The association between pre-treatment occupational skill level and mood and symptom burden in early-stage, postmenopausal breast cancer survivors during the first year of anastrozole therapy
- Author
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Nugent, Bethany D., Sereika, Susan M., Rosenzweig, Margaret, McCue, Michael, Merriman, John D., and Bender, Catherine M.
- Published
- 2016
- Full Text
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26. Trajectories of self‐reported cognitive function in postmenopausal women during adjuvant systemic therapy for breast cancer
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Merriman, John D., Sereika, Susan M., Brufsky, Adam M., McAuliffe, Priscilla F., McGuire, Kandace P., Myers, Jamie S., Phillips, Mary L., Ryan, Christopher M., Gentry, Amanda L., Jones, Lindsay D., and Bender, Catherine M.
- Published
- 2017
- Full Text
- View/download PDF
27. Profiles of Work and Quality of Life among Young Adult Cancer Survivors.
- Author
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Ghazal, Lauren V., Merriman, John D., Santacroce, Sheila J., Fletcher, Jason, Wright, Fay, and Dickson, Victoria Vaughan
- Subjects
- *
BEHAVIORAL research , *WORK , *RESEARCH methodology , *TIME , *SELF-evaluation , *SELF-perception , *CROSS-sectional method , *INTERVIEWING , *ECOLOGICAL research , *CANCER patients , *ABILITY , *T-test (Statistics) , *QUALITY of life , *HEMATOLOGIC malignancies , *QUESTIONNAIRES , *DATA analysis software , *GOAL (Psychology) - Abstract
Work ability, or the perception of one's ability to work presently and in the future, may impact quality of life (QOL) among young adult (YA) cancer survivors. Through a convergent mixed methods design, we explored work ability, work-related goals, and QOL among YA hematologic cancer survivors within five years of diagnosis. We described associations at the individual- and microsystem (work)- levels; and compared factors across low and high work ability groups. Participants (N = 40) completed a survey and interview via digital platforms. Qualitative analysis revealed self-assessed declines in work ability led to questioning work-related goals and influenced QOL. Integrated analysis led to the development of four profiles, growing our understanding of work's influence on QOL for YA cancer survivors, and identifying components YAs considered when contemplating work-related goals after a cancer diagnosis. Larger studies are needed to elucidate these profiles and identify modifiable factors to inform targeted interventions to improve QOL. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
28. sj-pdf-1-wjn-10.1177_01939459221120742 – Supplemental material for Profiles of Work and Quality of Life among Young Adult Cancer Survivors
- Author
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Ghazal, Lauren V., Merriman, John D., Santacroce, Sheila J., Fletcher, Jason, Wright, Fay, and Dickson, Victoria Vaughan
- Subjects
111099 Nursing not elsewhere classified ,FOS: Health sciences - Abstract
Supplemental material, sj-pdf-1-wjn-10.1177_01939459221120742 for Profiles of Work and Quality of Life among Young Adult Cancer Survivors by Lauren V. Ghazal, John D. Merriman, Sheila J. Santacroce, Jason Fletcher, Fay Wright and Victoria Vaughan Dickson in Western Journal of Nursing Research
- Published
- 2022
- Full Text
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29. Multiple Chronic Conditions among Seriously Ill Adults Receiving Palliative Care.
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Murali, Komal P., Yu, Gary, Merriman, John D., Vorderstrasse, Allison, Kelley, Amy S., and Brody, Abraham A.
- Subjects
TUMOR treatment ,OBSTRUCTIVE lung disease treatment ,STRUCTURAL equation modeling ,CHRONIC diseases ,CROSS-sectional method ,LIFE expectancy ,PATIENT-centered care ,METASTASIS ,CARDIOVASCULAR diseases ,MYOCARDIAL infarction ,DIABETES ,CATASTROPHIC illness ,COMPARATIVE studies ,OBSTRUCTIVE lung diseases ,DEMENTIA ,QUALITY of life ,SYMPTOMS ,DESCRIPTIVE statistics ,QUESTIONNAIRES ,RESEARCH funding ,TUMORS ,LYMPHOMAS ,DATA analysis software ,COMORBIDITY ,PALLIATIVE treatment ,HEART failure ,DISEASE complications ,ADULTS - Abstract
The objective of this study was to characterize multiple chronic conditions (MCCs) among seriously ill adults receiving palliative care at the end of life. A latent class analysis was conducted to identify latent subgroups of seriously ill older adults based on a baseline Charlson comorbidity index (CCI) measurement, a measure of comorbidity burden, and mortality risk. The three latent subgroups were: (1) low to moderate CCI with MCC, (2) high CCI with MCC, and (3) high CCI and metastatic cancer. The "low to moderate CCI and MCC" subgroup included older adults with chronic obstructive pulmonary disease (COPD), cardiovascular disease, congestive heart failure, myocardial infarction, dementia, diabetes, and lymphoma. A "high CCI and MCC" subgroup included individuals with severe illness including liver or renal disease among other MCCs. A "high CCI and metastatic cancer" included all participants with metastatic cancer. This study sheds light on the MCC profile of seriously ill adults receiving palliative care. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
30. Multiple Chronic Conditions among Seriously Ill Adults Receiving Palliative Care
- Author
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Murali, Komal P., primary, Yu, Gary, additional, Merriman, John D., additional, Vorderstrasse, Allison, additional, Kelley, Amy S., additional, and Brody, Abraham A., additional
- Published
- 2021
- Full Text
- View/download PDF
31. Patterns of Change in Cognitive Function With Anastrozole Therapy
- Author
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Bender, Catherine M., Merriman, John D., Gentry, Amanda L., Ahrendt, Gretchen M., Berga, Sarah L., Brufsky, Adam M., Casillo, Frances E., Dailey, Meredith M., Erickson, Kirk I., Kratofil, Frances M., McAuliffe, Priscilla F., Rosenzweig, Margaret Q., Ryan, Christopher M., and Sereika, Susan M.
- Published
- 2015
- Full Text
- View/download PDF
32. Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery
- Author
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Doong, Sy-Huey, Dhruva, Anand, Dunn, Laura B., West, Claudia, Paul, Steven M., Cooper, Bruce A., Elboim, Charles, Abrams, Gary, Merriman, John D., Langford, Dale J., Leutwyler, Heather, Baggott, Christina, Kober, Kord, Aouizerat, Bradley E., and Miaskowski, Christine
- Published
- 2015
- Full Text
- View/download PDF
33. Identification of Genetic Markers Associated With Self-Reported Attentional Function
- Author
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Merriman, John D.
- Subjects
Nursing ,attention ,cancer ,cytokine genes ,inflammation ,neurotransmitter genes ,radiation therapy - Abstract
Subgroups of individuals may be at greater risk for changes in attentional function before, during, and after cancer treatment. Proposed mechanisms for these changes may include genetic predisposition to cytokine and neurotransmitter dysregulation. The purposes of this dissertation research were to identify subgroups of individuals with distinct trajectories of attentional function and to evaluate for phenotypic and genotypic (i.e., variations in cytokine and neurotransmission genes) differences among these subgroups. Self-reported attentional function was evaluated in two independent samples using the Attentional Function Index. In the first sample of 167 oncology patients receiving radiation therapy and their 85 family caregivers, three latent classes were identified using growth mixture modeling: high (15.5%), moderate-to-high (48.0%), and moderate (36.5%) attentional function. Participants in the moderate class were younger, with more comorbidities and lower functional status. Multivariable models controlled for phenotypic differences among classes, population stratification due to race/ethnicity, and other genetic variations in the same gene. A cytokine gene variation (i.e., IL6 rs1800795) remained a significant genotypic predictor of latent class membership in multivariable models. In addition, two catecholaminergic gene variations (i.e., ADRA1D rs4815675, SLC6A3 rs37022), a gamma-aminobutyric acid (GABA)-ergic gene variation (i.e., SLC6A1 rs2697138), and two serotonergic gene variations (i.e., HTR2A rs2296972, rs9534496) remained significant predictors of latent class membership. In the second sample of 397 patients with breast cancer, three latent classes were identified: high (41.6%), moderate (25.4%), and low-moderate (33.0%) attentional function. Patients in the low-moderate class were younger than those in the high class, with more comorbidities and lower functional status than the other two classes. Controlling for phenotypic differences among classes, population stratification due to race/ethnicity, and other genetic variations in the same gene, a cytokine gene variation (i.e., IL1R1 rs949963) remained a significant genotypic predictor of latent class membership. Findings provide evidence of subgroups of individuals with distinct trajectories of attentional function and of genetic associations with subgroup membership. These findings suggest that variations in genes that encode for inflammatory cytokines and for three distinct but related neurotransmission systems are involved in attentional function.
- Published
- 2013
34. "Now Everybody Is Thinking About Things Like That." Young Adult Cancer Survivors Reimagining Work During the COVID-19 Pandemic.
- Author
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Ghazal, Lauren V., Santacroce, Sheila J., Merriman, John D., and Dickson, Victoria Vaughan
- Published
- 2022
- Full Text
- View/download PDF
35. Predictors of the Trajectories of Self-Reported Attentional Fatigue in Women With Breast Cancer Undergoing Radiation Therapy
- Author
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Merriman, John D.
- Subjects
Health Sciences, Nursing ,AFI ,attentional fatigue ,attentional function index ,breast cancer ,radiation therapy ,symptom trajectories - Abstract
This study of breast cancer patients who underwent radiation therapy (RT) examined how attentional fatigue changed from the time of simulation to four months after the completion of RT and investigated whether specific variables predicted initial levels of attentional fatigue and characteristics of the trajectories of attentional fatigue. Seventy-three women completed a number of measures (i.e., Attentional Function Index, General Sleep Disturbance Scale, Center for Epidemiologic Studies-Depression scale, Spielberger State-Trait Anxiety Inventories, Brief Pain Inventory) over six months. Descriptive statistics and hierarchical linear modeling were used for data analysis. Large amounts of inter-individual variability were found in the trajectories of attentional fatigue. At baseline, higher levels of attentional fatigue were associated with younger age, not working, a higher number of comorbidities, and higher levels of trait anxiety. The trajectory of attentional fatigue improved over time for women with a higher body mass index at baseline. This study is the first to identify predictors of inter-individual variability in attentional fatigue in women with breast cancer undergoing RT. The various predictors should be considered in the design of future correlational and interventional studies in this population.
- Published
- 2009
36. An Adapted Conceptual Model Integrating Palliative Care in Serious Illness and Multiple Chronic Conditions
- Author
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Murali, Komal Patel, primary, Merriman, John D., additional, Yu, Gary, additional, Vorderstrasse, Allison, additional, Kelley, Amy, additional, and Brody, Abraham A., additional
- Published
- 2020
- Full Text
- View/download PDF
37. 4228 A latent class analysis of seriously ill adults with multiple chronic conditions receiving palliative care
- Author
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Murali, Komal, primary, Yu, Gary, additional, Merriman, John D., additional, and Brody, Abraham A., additional
- Published
- 2020
- Full Text
- View/download PDF
38. Predictors of the Trajectories of Self-Reported Attentional Fatigue in Women With Breast Cancer Undergoing Radiation Therapy
- Author
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Merriman, John D., Jansen, Catherine, Koetters, Theresa, West, Claudia, Dodd, Marylin, Lee, Kathryn, Paul, Steven M., Aouizerat, Bradley E., Cooper, Bruce A., Swift, Patrick S., Wara, William, and Miaskowski, Christine
- Published
- 2010
- Full Text
- View/download PDF
39. Supplemental_Files_BRN - Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms
- Author
-
Knisely, Mitchell R., Maserati, Megan, Heinsberg, Lacey W., Shah, Lisa L., Hongjin Li, Yehui Zhu, Ma, Yumi, Graves, Letitia Y., Merriman, John D., and Conley, Yvette P.
- Subjects
111099 Nursing not elsewhere classified ,FOS: Health sciences - Abstract
Supplemental_Files_BRN for Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms by Mitchell R. Knisely, Megan Maserati, Lacey W. Heinsberg, Lisa L. Shah, Hongjin Li, Yehui Zhu, Yumi Ma, Letitia Y. Graves, John D. Merriman and Yvette P. Conley in Biological Research For Nursing
- Published
- 2019
- Full Text
- View/download PDF
40. Supplemental Material, Merriman_17120154_toSage_SuppTbls - Exploratory Study of Associations Between DNA Repair and Oxidative Stress Gene Polymorphisms and Cognitive Problems Reported by Postmenopausal Women With and Without Breast Cancer
- Author
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Merriman, John D., Sereika, Susan M., Conley, Yvette P., Koleck, Theresa A., Yehui Zhu, Phillips, Mary L., Bertocci, Michele A., Brufsky, Adam M., and Bender, Catherine M.
- Subjects
111099 Nursing not elsewhere classified ,FOS: Health sciences - Abstract
Supplemental Material, Merriman_17120154_toSage_SuppTbls for Exploratory Study of Associations Between DNA Repair and Oxidative Stress Gene Polymorphisms and Cognitive Problems Reported by Postmenopausal Women With and Without Breast Cancer by John D. Merriman, Susan M. Sereika, Yvette P. Conley, Theresa A. Koleck, Yehui Zhu, Mary L. Phillips, Michele A. Bertocci, Adam M. Brufsky, and Catherine M. Bender in Biological Research For Nursing
- Published
- 2018
- Full Text
- View/download PDF
41. Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms
- Author
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Knisely, Mitchell R., primary, Maserati, Megan, additional, Heinsberg, Lacey W., additional, Shah, Lisa L., additional, Li, Hongjin, additional, Zhu, Yehui, additional, Ma, Yumi, additional, Graves, Letitia Y., additional, Merriman, John D., additional, and Conley, Yvette P., additional
- Published
- 2019
- Full Text
- View/download PDF
42. Exploratory Study of Associations Between DNA Repair and Oxidative Stress Gene Polymorphisms and Cognitive Problems Reported by Postmenopausal Women With and Without Breast Cancer
- Author
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Merriman, John D., primary, Sereika, Susan M., additional, Conley, Yvette P., additional, Koleck, Theresa A., additional, Zhu, Yehui, additional, Phillips, Mary L., additional, Bertocci, Michele A., additional, Brufsky, Adam M., additional, and Bender, Catherine M., additional
- Published
- 2018
- Full Text
- View/download PDF
43. Cancer- and treatment-related cognitive changes: what can we do now? What lies ahead?
- Author
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Bender, Catherine M. and Merriman, John D.
- Subjects
Cancer -- Care and treatment ,Cognition disorders -- Development and progression ,Health - Abstract
The common term 'chemobrain' belies the complex nature of the problem of changes in cognitive function experienced by patients with cancer. [1] Multiple factors contribute to these cognitive changes. Moreover, [...]
- Published
- 2014
44. Exploratory Study of Associations Between DNA Repair and Oxidative Stress Gene Polymorphisms and Cognitive Problems Reported by Postmenopausal Women With and Without Breast Cancer.
- Author
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Merriman, John D., Sereika, Susan M., Conley, Yvette P., Koleck, Theresa A., Zhu, Yehui, Phillips, Mary L., Bertocci, Michele A., Brufsky, Adam M., and Bender, Catherine M.
- Subjects
- *
DNA repair , *OXIDATIVE stress , *GENETIC polymorphisms , *POSTMENOPAUSE , *BREAST cancer , *COGNITION disorders , *LOGISTIC regression analysis , *GENOTYPES - Abstract
Purpose: Women with breast cancer report varying frequencies of cognitive problems during adjuvant systemic therapy. This variability suggests latent subgroups. Therefore, we identified latent subgroups of self-reported cognitive problems among postmenopausal women with and without breast cancer. We explored associations between membership in these subgroups and (a) demographic, clinical, and symptom characteristics and (b) variations in candidate gene polymorphisms. Methods: We evaluated frequency of cognitive problems using the Patient Assessment of Own Functioning Inventory. Growth mixture modeling identified latent subgroups over 18 months of adjuvant systemic therapy and at matched time points for women without cancer (N = 331). We evaluated for differences among subgroups in demographic, clinical, and symptom characteristics and in 41 single nucleotide polymorphisms in 10 candidate genes involved in DNA repair and oxidative stress pathways (n = 199). We modeled associations between genotypes and subgroup membership using multinomial logistic regression. Results: We identified three latent subgroups: more frequent, persistent, and almost never. Receipt of chemotherapy plus anastrozole, depressive symptoms, and baseline neuropathic symptoms increased the odds of belonging to the more frequent subgroup. Anxiety and depressive symptoms increased the odds of belonging to the persistent subgroup. With covariates controlled for, carrying the ERCC5 rs873601 G minor allele increased the odds of reporting more frequent cognitive problems. Conclusions: Chemotherapy plus anastrozole, depressive symptoms, and presence of neuropathic symptoms may predict more frequent cognitive problems during systemic therapy that later resolve. Mood dysregulation before therapy may predict persistent cognitive problems during therapy. ERCC5 genotype may influence frequency of cognitive problems after controlling for these risk factors. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
45. Trajectories of Cognitive Function and Associated Phenotypic and Genotypic Factors in Breast Cancer.
- Author
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Bender, Catherine M., Merriman, John D., Sereika, Susan M., Gentry, Amanda L., Casillo, Frances E., Koleck, Theresa A., Rosenzweig, Margaret Q., Brufsky, Adam M., McAuliffe, Priscilla, Yehui Zhu, and Conley, Yvette P.
- Subjects
- *
ATTENTION , *BREAST tumors , *COGNITION , *COMBINED modality therapy , *CONFIDENCE intervals , *GENETIC polymorphisms , *LONGITUDINAL method , *MARITAL status , *MEMORY , *MULTIVARIATE analysis , *PROBABILITY theory , *RESEARCH funding , *STATISTICS , *MATHEMATICAL variables , *PHENOTYPES , *LOGISTIC regression analysis , *SAMPLE size (Statistics) , *DATA analysis , *EDUCATIONAL attainment , *PRE-tests & post-tests , *REPEATED measures design , *POSTMENOPAUSE , *EXECUTIVE function , *DATA analysis software , *DESCRIPTIVE statistics , *ODDS ratio , *GENOTYPES , *GENETICS - Abstract
OBJECTIVES: This study identified women with unique trajectories of executive function, concentration, and visual working memory before and during adjuvant therapy for breast cancer, and examined phenotypic and genotypic predictors associated with subgroups. SAMPLE & SETTING: 399 postmenopausal women, of whom 288 were women with early-stage breast cancer and 111 were women without breast cancer, matched on age and years of education to the women with breast cancer, and all at an urban cancer center. METHODS & VARIABLES: A repeated-measures design was used; assessments occurred before adjuvant therapy and every six months posttherapy initiation. Group-based trajectory modeling determined subgroups. Multinomial logistic regression identified phenotypic and genotypic characteristics. RESULTS: Three executive function and concentration trajectory subgroups were identified: low, moderate, and high; two visual working memory subgroups were identified: low and high. IMPLICATIONS FOR NURSING: Advancing age, greater pretherapy fatigue, and poorer pretherapy cognitive function are associated with the low subgroups. DNA repair and oxidative stress mechanisms may be involved in the cognitive changes that women experience. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
46. Trajectories of self-reported cognitive function in postmenopausal women during adjuvant systemic therapy for breast cancer
- Author
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Merriman, John D., primary, Sereika, Susan M., additional, Brufsky, Adam M., additional, McAuliffe, Priscilla F., additional, McGuire, Kandace P., additional, Myers, Jamie S., additional, Phillips, Mary L., additional, Ryan, Christopher M., additional, Gentry, Amanda L., additional, Jones, Lindsay D., additional, and Bender, Catherine M., additional
- Published
- 2015
- Full Text
- View/download PDF
47. Trajectories of fear of recurrence in women with breast cancer
- Author
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Dunn, Laura B., primary, Langford, Dale J., additional, Paul, Steven M., additional, Berman, Molly B., additional, Shumay, Dianne M., additional, Kober, Kord, additional, Merriman, John D., additional, West, Claudia, additional, Neuhaus, John M., additional, and Miaskowski, Christine, additional
- Published
- 2014
- Full Text
- View/download PDF
48. Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery
- Author
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Doong, Sy-Huey, primary, Dhruva, Anand, additional, Dunn, Laura B., additional, West, Claudia, additional, Paul, Steven M., additional, Cooper, Bruce A., additional, Elboim, Charles, additional, Abrams, Gary, additional, Merriman, John D., additional, Langford, Dale J., additional, Leutwyler, Heather, additional, Baggott, Christina, additional, Kober, Kord, additional, Aouizerat, Bradley E., additional, and Miaskowski, Christine, additional
- Published
- 2014
- Full Text
- View/download PDF
49. Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers
- Author
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Miaskowski, Christine, primary, Cataldo, Janine K., additional, Baggott, Christina R., additional, West, Claudia, additional, Dunn, Laura B., additional, Dhruva, Anand, additional, Merriman, John D., additional, Langford, Dale J., additional, Kober, Kord M., additional, Paul, Steven M., additional, Cooper, Bruce A., additional, and Aouizerat, Bradley E., additional
- Published
- 2014
- Full Text
- View/download PDF
50. Cytokine Gene Associations With Self-Report Ratings of Morning and Evening Fatigue in Oncology Patients and Their Family Caregivers
- Author
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Dhruva, Anand, primary, Aouizerat, Bradley E., additional, Cooper, Bruce, additional, Paul, Steven M., additional, Dodd, Marylin, additional, West, Claudia, additional, Wara, William, additional, Lee, Kathryn, additional, Dunn, Laura B., additional, Langford, Dale J., additional, Merriman, John D., additional, Baggott, Christina, additional, Cataldo, Janine, additional, Ritchie, Christine, additional, Kober, Kord M., additional, Leutwyler, Heather, additional, and Miaskowski, Christine, additional
- Published
- 2014
- Full Text
- View/download PDF
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