784 results on '"Merriman, John"'
Search Results
2. A Workforce Divided: Community, Labor, and the State in Saint-Nazaire's Shipbuilding Industry, 1880-1910 (review)
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Merriman, John M
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- 2004
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3. The impact of the Black Death (1348-1349) on the Winchester Diocese through a comparison of the mortality evidence of the rural community and the clergy
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Merriman, John, Welch, Christina, and Skinner, Patricia
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The Black Death was one of the most devastating pandemics in human history. Reaching England in 1348, the Black Death ravaged towns and countryside causing widespread disruption and death. In a novel approach, this thesis assesses how a medieval diocese dealt with both its clergy and with its estates in meeting the challenges provided by the Black Death, as it swept through the Winchester Diocese. Details of the specific and differing strategies employed by William Edington, bishop at the time, are compared and analysed. The different 'hats' of manorial landlord and ecclesiastical leader that Bishop Edington had to wear are revealed as the body count from the pestilence rose. The Winchester pipe rolls provided a rich legacy of information for this thesis. The pipe rolls contain a vast amount of details of the economic side of manorial organisation. Sharp focus has been placed on entries for selected Somerset and North Hampshire manors for the period of the Black Death. Entries under the chilling heading 'Defectus per Pestilentiam' record the names of many of the people who worked on the land and who died from the pestilence. The resulting mortality rates calculated for these selected manors of the Winchester Diocese are compared with other studies completed on other areas of England during the Black Death. The impact of the Black Death on the clergy of the Winchester Diocese is another major feature of this thesis. Using the registers of Bishop Edington, Bishop of Winchester, a key source of clergy data, assumptions about clerical mortality and pastoral care are analysed and re-assessed. The calculation of a mortality rate for the clergy of the diocese during the Black Death has broken new ground. The data collected has enabled a number of short and long term issues to be addressed, for example, 'What was Bishop Edington's reaction to the Black Death?' and 'Did many priests really shamefully desert from their cures?' The compatibility of mortality suffered by the selected manors of the Winchester Diocese, compared to other areas of England, helps add a new contribution to knowledge of the period. The mortality rate calculated in this thesis provides fresh insight into the impact of the Black Death on the clergy. The percentage of deaths calculated correlrates well with studies of the clergy in other dioceses of medieval England at the time. This study, then, reveals for the first time, how the manorial organisation and ecclesiastical administration of the medieval diocese of Winchester coped during one of the most challenging periods in England's history.
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- 2021
4. Chapter 36 On the Loose:The Impact of Rumors and Mouchards in the Ardèche during the Second Republic
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Merriman, John, primary
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- 2022
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5. Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study.
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Petimar, Joshua, Young, Jessica G., Yu, Han, Rifas-Shiman, Sheryl L., Daley, Matthew F., Heerman, William J., Janicke, David M., Jones, W. Schuyler, Lewis, Kristina H., Lin, Pi-I D., Prentice, Carly, Merriman, John W., Toh, Sengwee, and Block, Jason P.
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STATISTICAL models ,ELECTRONIC health records ,WEIGHT gain ,ANTIDEPRESSANTS ,PATIENT compliance - Abstract
Weight gain associated with antidepressants is a commonly reported side effect and may influence whether patients take or continue to take these medications. This study examines the electronic health record information of patients who were newly prescribed 1 of 8 common antidepressant medications to estimate weight gain associated with each over time. Visual Abstract. Medication-Induced Weight Change Across Common Antidepressant Treatments: Weight gain associated with antidepressants is a commonly reported side effect and may influence whether patients take or continue to take these medications. This study examines the electronic health record information of patients who were newly prescribed 1 of 8 common antidepressant medications to estimate weight gain associated with each over time. Background: Antidepressants are among the most commonly prescribed medications, but evidence on comparative weight change for specific first-line treatments is limited. Objective: To compare weight change across common first-line antidepressant treatments by emulating a target trial. Design: Observational cohort study over 24 months. Setting: Electronic health record (EHR) data from 2010 to 2019 across 8 U.S. health systems. Participants: 183 118 patients. Measurements: Prescription data determined initiation of treatment with sertraline, citalopram, escitalopram, fluoxetine, paroxetine, bupropion, duloxetine, or venlafaxine. The investigators estimated the population-level effects of initiating each treatment, relative to sertraline, on mean weight change (primary) and the probability of gaining at least 5% of baseline weight (secondary) 6 months after initiation. Inverse probability weighting of repeated outcome marginal structural models was used to account for baseline confounding and informative outcome measurement. In secondary analyses, the effects of initiating and adhering to each treatment protocol were estimated. Results: Compared with that for sertraline, estimated 6-month weight gain was higher for escitalopram (difference, 0.41 kg [95% CI, 0.31 to 0.52 kg]), paroxetine (difference, 0.37 kg [CI, 0.20 to 0.54 kg]), duloxetine (difference, 0.34 kg [CI, 0.22 to 0.44 kg]), venlafaxine (difference, 0.17 kg [CI, 0.03 to 0.31 kg]), and citalopram (difference, 0.12 kg [CI, 0.02 to 0.23 kg]); similar for fluoxetine (difference, −0.07 kg [CI, −0.19 to 0.04 kg]); and lower for bupropion (difference, −0.22 kg [CI, −0.33 to −0.12 kg]). Escitalopram, paroxetine, and duloxetine were associated with 10% to 15% higher risk for gaining at least 5% of baseline weight, whereas bupropion was associated with 15% reduced risk. When the effects of initiation and adherence were estimated, associations were stronger but had wider CIs. Six-month adherence ranged from 28% (duloxetine) to 41% (bupropion). Limitation: No data on medication dispensing, low medication adherence, incomplete data on adherence, and incomplete data on weight measures across time points. Conclusion: Small differences in mean weight change were found between 8 first-line antidepressants, with bupropion consistently showing the least weight gain, although adherence to medications over follow-up was low. Clinicians could consider potential weight gain when initiating antidepressant treatment. Primary Funding Source: National Institutes of Health. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Trends of Antihypertensive Prescription Among US Adults From 2010 to 2019 and Changes Following Treatment Guidelines: Analysis of Multicenter Electronic Health Records.
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Pi-I Debby Lin, Rifas-Shiman, Sheryl, Merriman, John, Petimar, Joshua, Han Yu, Daley, Matthew F., Janicke, David M., Heerman, William J., Bailey, L. Charles, Maeztu, Carlos, Young, Jessica, and Block, Jason P.
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- 2024
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7. The Spectre of the Commune and French Anarchism in the 1890s
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Merriman, John, Levy, Carl, editor, and Adams, Matthew S., editor
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- 2019
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8. “Now everybody is thinking about things like that.”: Young Adult Cancer Survivors Reimagining Work During the COVID-19 Pandemic
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Ghazal, Lauren V., Santacroce, Sheila J., Merriman, John D., and Dickson, Victoria Vaughan
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- 2021
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9. Gender Differences in Predictors of Quality of Life at the Initiation of Radiation Therapy.
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West, Claudia, Paul, Steven M, Dunn, Laura, Dhruva, Anand, Merriman, John, and Miaskowski, Christine
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Humans ,Radiotherapy ,Prospective Studies ,Depression ,Anxiety ,Sex Factors ,Sex Characteristics ,Forecasting ,Quality of Life ,Aged ,Middle Aged ,Female ,Male ,Surveys and Questionnaires ,anxiety ,depression ,gender differences ,quality of life ,radiation therapy ,Mental Health ,Behavioral and Social Science ,Clinical Research ,Management of diseases and conditions ,7.1 Individual care needs ,Nursing - Abstract
Purpose/objectivesTo evaluate gender differences in quality of life (QOL), demographic, clinical, and symptom characteristics. DesignProspective, observational. SettingTwo radiation oncology departments in northern California. Sample185 patients before initiation of radiation therapy (RT). MethodsAt their RT simulation visit, patients completed a demographic questionnaire, a measure of QOL, and symptom-specific scales. Backward elimination regression analyses were conducted to determine the significant predictors of QOL .Main research variablesQOL, gender, and 20 potential predictors .FindingsIn women, depressive symptoms, functional status, age, and having children at home explained 64% of the variance in QOL. In men, depressive symptoms, state anxiety, number of comorbidities, being a member of a racial or ethnic minority, and age explained 70% of the variance in QOL .ConclusionsPredictors of QOL differed by gender. Depressive symptom score was the greatest contributor to QOL in both genders. .Implications for nursingNurses need to assess for QOL and depression at the initiation of RT. Knowledge of the different predictors of QOL may be useful in the design of gender-specific interventions to improve QOL.
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- 2015
10. Trajectories of fear of recurrence in women with breast cancer.
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Dunn, Laura B, Langford, Dale J, Paul, Steven M, Berman, Molly B, Shumay, Dianne M, Kober, Kord, Merriman, John D, West, Claudia, Neuhaus, John M, and Miaskowski, Christine
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Humans ,Breast Neoplasms ,Neoplasm Recurrence ,Local ,Postoperative Period ,Adaptation ,Psychological ,Fear ,Anxiety Disorders ,Quality of Life ,Middle Aged ,Survivors ,Health Services Needs and Demand ,Female ,Mind and Body ,Cancer ,Behavioral and Social Science ,Mental Health ,Clinical Research ,Patient Safety ,Breast Cancer ,7.3 Management and decision making ,7.1 Individual care needs ,Management of diseases and conditions ,Oncology ,Breast cancer ,Fear of recurrence ,Psychological symptoms ,Symptom trajectories ,Hierarchical linear modeling ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Oncology & Carcinogenesis - Abstract
PurposeAlthough fear of recurrence (FCR) is common among cancer survivors, it remains unclear what factors predict initial levels (e.g., prior to surgery) or changes in FCR in the post-treatment period. Among women treated for breast cancer, this study evaluated the effects of demographic, clinical, symptom, and psychosocial adjustment characteristics on the initial (preoperative) levels of FCR and trajectories of FCR over 6 months following surgery.MethodsPrior to and for 6 months following breast cancer surgery, 396 women were assessed for demographic and clinical (disease and treatment) characteristics, symptoms, psychological adjustment characteristics, and quality of life (QOL). FCR was assessed using a four-item subscale from the QOL instrument. Hierarchical linear modeling was used to examine changes in FCR scores and to identify predictors of inter-individual differences in preoperative FCR levels and trajectories over 6 months.ResultsFrom before surgery to 6 months post-operatively, women with breast cancer showed a high degree of inter-individual variability in FCR. Preoperatively, women who lived with someone, experienced greater changes in spiritual life, had higher state anxiety, had more difficulty coping, or experienced more distress due to diagnosis or distress to family members reported higher FCR scores. Patients who reported better overall physical health and higher FCR scores at enrollment demonstrated a steeper decrease in FCR scores over time.ConclusionsThese findings highlight inter-individual heterogeneity in initial levels and changes in FCR over time among women undergoing breast cancer surgery. Further work is needed to identify and provide interventions for women experiencing FCR during and after breast cancer treatment.
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- 2015
11. Associations between catecholaminergic, GABAergic, and serotonergic genes and self-reported attentional function in oncology patients and their family caregivers.
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Merriman, John D, Aouizerat, Bradley E, Cataldo, Janine K, Dunn, Laura B, Kober, Kord, Langford, Dale J, West, Claudia, Cooper, Bruce A, Paul, Steven M, and Miaskowski, Christine
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Humans ,Breast Neoplasms ,Catecholamines ,gamma-Aminobutyric Acid ,Serotonin Agents ,Cytokines ,Longitudinal Studies ,Family ,Attention ,Genotype ,Phenotype ,Polymorphism ,Single Nucleotide ,Aged ,Middle Aged ,Caregivers ,California ,Female ,Male ,Self Report ,Attentional function ,Cancer ,Gamma-aminobutyric acid ,Neurotransmission ,Serotonin ,Genetic Testing ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Nursing ,Oncology and Carcinogenesis - Abstract
Purpose of the researchEvaluate for associations between variations in genes involved in catecholaminergic, gamma-aminobutyric acid (GABA)-ergic, and serotonergic mechanisms of neurotransmission and attentional function latent classes.Patients and methodsThis descriptive, longitudinal study was conducted at two radiation therapy departments. The sample included three latent classes of individuals with distinct trajectories of self-reported attentional function during radiation therapy, who were previously identified using growth mixture modeling among 167 oncology patients and 85 of their family caregivers. Multivariable models were used to evaluate for genotypic associations of neurotransmission genes with attentional function latent class membership, after controlling for covariates.ResultsVariations in catecholaminergic (i.e., ADRA1D rs4815675, SLC6A3 rs37022), GABAergic (i.e., SLC6A1 rs2697138), and serotonergic (i.e., HTR2A rs2296972, rs9534496) neurotransmission genes were significant predictors of latent class membership in multivariable models.ConclusionsFindings suggest that variations in genes that encode for three distinct but related neurotransmission systems are involved in alterations in attentional function. Knowledge of both phenotypic and genetic markers associated with alterations in attentional function can be used by clinicians to identify patients and family caregivers who are at higher risk for this symptom. Increased understanding of the genetic markers associated with alterations in attentional function may provide insights into the underlying mechanisms for this significant clinical problem.
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- 2015
12. Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers.
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Miaskowski, Christine, Cataldo, Janine K, Baggott, Christina R, West, Claudia, Dunn, Laura B, Dhruva, Anand, Merriman, John D, Langford, Dale J, Kober, Kord M, Paul, Steven M, Cooper, Bruce A, and Aouizerat, Bradley E
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Humans ,Neoplasms ,Cytokines ,Severity of Illness Index ,Regression Analysis ,Anxiety ,Age Distribution ,Sex Distribution ,Genotype ,Phenotype ,Aged ,Middle Aged ,Caregivers ,Female ,Male ,Genetic Variation ,Behavioral and Social Science ,Cancer ,Genetics ,Mental Health ,Biotechnology ,2.1 Biological and endogenous factors ,Aetiology ,Radiation therapy ,Single nucleotide polymorphism ,Family caregiver ,Trait anxiety ,State anxiety ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Oncology & Carcinogenesis - Abstract
PurposeAnxiety is common among cancer patients and their family caregivers (FCs) and is associated with poorer outcomes. Recently, associations between inflammation and anxiety were identified. However, the relationship between variations in cytokine genes and anxiety warrants investigation. Therefore, phenotypic and genotypic characteristics associated with trait and state anxiety were evaluated in a sample of 167 oncology patients with breast, prostate, lung, or brain cancer and 85 of their FCs.MethodsUsing multiple regression analyses, the associations between participants' demographic and clinical characteristics as well as variations in cytokine genes and trait and state anxiety were evaluated.ResultsIn the bivariate analyses, a number of phenotypic characteristics were associated with both trait and state anxiety (e.g., age, functional status). However, some associations were specific only to trait anxiety (e.g., number of comorbid conditions) or state anxiety (e.g., participation with a FC). Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear factor kappa beta 2 (NFKB2)) were associated with trait anxiety, and variations in two genes (i.e., IL1R2, tumor necrosis factor alpha (TNFA)) were associated with state anxiety.ConclusionsThese findings suggest that both trait and state anxiety need to be assessed in oncology patients and their FCs. Furthermore, variations in cytokine genes may contribute to higher levels of anxiety in oncology patients and their FCs.
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- 2015
13. Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.
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Cooper, Bruce, Paul, Steven, West, Claudia, Langford, Dale, Merriman, John, Baggott, Christina, Miaskowski, Christine, Aouizerat, Bradley, Lee, Kathryn, Leutwyler, Heather, Cataldo, Janine, Dunn, Laura, Ritchie, Christine, Dhruva, Anand, Dodd, Marylin, Wara, William, and Kober, Kord
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breast cancer ,cytokines ,evening fatigue ,genetics ,interleukin 4 ,morning fatigue ,tumor necrosis factor alpha ,Caregivers ,Cytokines ,Fatigue ,Female ,Genetic Association Studies ,Genetic Markers ,Haplotypes ,Humans ,Male ,Middle Aged ,Neoplasms ,Phenotype ,Polymorphism ,Genetic ,Polymorphism ,Single Nucleotide ,Regression Analysis ,Time - Abstract
The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample of 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their family caregivers, growth mixture modeling was used to identify latent classes of individuals based on ratings of morning and evening fatigue obtained prior to, during, and for 4 months following completion of radiation therapy. Differences in single nucleotide polymorphisms and haplotypes in 15 cytokine genes were evaluated between the latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on morning and evening fatigue class membership. Associations were found between morning fatigue and number of comorbidities as well as variations in tumor necrosis factor alpha (TNFA) rs1800629 and rs3093662. Evening fatigue was associated with caring for children at home and variations in interleukin 4 (IL4) rs2243248 and TNFA rs2229094. Younger age and lower performance status were associated with both morning and evening fatigue. These findings suggest that inflammatory mediators are associated with the development of morning and evening fatigue. However, because different phenotypic characteristics and genomic markers are associated with diurnal variations in fatigue, morning and evening fatigue may be distinct but related symptoms.
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- 2015
14. Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.
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Dhruva, Anand, Aouizerat, Bradley E, Cooper, Bruce, Paul, Steven M, Dodd, Marylin, West, Claudia, Wara, William, Lee, Kathryn, Dunn, Laura B, Langford, Dale J, Merriman, John D, Baggott, Christina, Cataldo, Janine, Ritchie, Christine, Kober, Kord M, Leutwyler, Heather, and Miaskowski, Christine
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Humans ,Neoplasms ,Fatigue ,Genetic Markers ,Cytokines ,Regression Analysis ,Haplotypes ,Phenotype ,Polymorphism ,Genetic ,Polymorphism ,Single Nucleotide ,Time ,Middle Aged ,Caregivers ,Female ,Male ,Genetic Association Studies ,breast cancer ,cytokines ,evening fatigue ,genetics ,interleukin 4 ,morning fatigue ,tumor necrosis factor alpha ,Clinical Research ,Cancer ,Genetics ,Aging ,2.1 Biological and endogenous factors ,Aetiology ,Nursing - Abstract
The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample of 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their family caregivers, growth mixture modeling was used to identify latent classes of individuals based on ratings of morning and evening fatigue obtained prior to, during, and for 4 months following completion of radiation therapy. Differences in single nucleotide polymorphisms and haplotypes in 15 cytokine genes were evaluated between the latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on morning and evening fatigue class membership. Associations were found between morning fatigue and number of comorbidities as well as variations in tumor necrosis factor alpha (TNFA) rs1800629 and rs3093662. Evening fatigue was associated with caring for children at home and variations in interleukin 4 (IL4) rs2243248 and TNFA rs2229094. Younger age and lower performance status were associated with both morning and evening fatigue. These findings suggest that inflammatory mediators are associated with the development of morning and evening fatigue. However, because different phenotypic characteristics and genomic markers are associated with diurnal variations in fatigue, morning and evening fatigue may be distinct but related symptoms.
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- 2015
15. 1. Edo and Paris
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McClain, James L., primary and Merriman, John M., additional
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- 2020
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16. Latent Class Analysis of Symptom Burden Among Seriously Ill Adults at the End of Life
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Murali, Komal P., Yu, Gary, Merriman, John D., Vorderstrasse, Allison, Kelley, Amy S., and Brody, Abraham A.
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- 2021
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17. Financial Toxicity in Adolescents and Young Adults With Cancer: A Concept Analysis
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Ghazal, Lauren V., Gormley, Maurade, Merriman, John D., and Santacroce, Sheila J.
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- 2021
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18. Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer
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Saad, Shanwell, Dunn, Laura B, Koetters, Theresa, Dhruva, Anand, Langford, Dale J, Merriman, John D, West, Claudia, Paul, Steven M, Cooper, Bruce, Cataldo, Janine, Hamolsky, Deborah, Elboim, Charles, Aouizerat, Bradley E, and Miaskowski, Christine
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Clinical Research ,Cancer ,Women's Health ,Depression ,Mental Illness ,Mental Health ,Brain Disorders ,Genetics ,Breast Cancer ,Adult ,Age Factors ,Aged ,Breast Neoplasms ,California ,Causality ,Comorbidity ,Female ,Genetic Predisposition to Disease ,Haplotypes ,Humans ,Interleukin-6 ,Middle Aged ,Polymorphism ,Single Nucleotide ,Receptors ,Interferon ,Socioeconomic Factors ,Tumor Necrosis Factor-alpha ,Interferon gamma Receptor ,Breast cancer ,Cytokines ,Depressive symptoms ,Subsyndromal depression ,Interleukin 6 ,Tumor necrosis factor alpha ,Interferon gamma ,Nursing ,Oncology and Carcinogenesis ,Oncology and carcinogenesis ,Health services and systems - Abstract
PurposeThis study explored the relationships between variations in cytokines genes and depressive symptoms in a sample of patients who were assessed prior to and for six months following breast cancer surgery. Phenotypic differences between Resilient (n = 155) and Subsyndromal (n = 180) depressive symptom classes, as well as variations in cytokine genes were evaluated.MethodPatients were recruited prior to surgery and followed for six months. Growth mixture modeling was used to identify distinct latent classes based on Center for Epidemiological Studies Depression (CES-D) Scale scores. Eighty-two single nucleotide polymorphisms and 35 haplotypes among 15 candidate cytokine genes were evaluated.ResultsPatients in the Subsyndromal class were significantly younger, more likely to be married or partnered, and reported a significantly lower functional status. Variation in three cytokine genes (i.e., interferon gamma receptor 1 (IFNGR1 rs9376268), interleukin 6 (IL6 rs2069840), tumor necrosis factor alpha (TNFA rs1799964)), as well as age and functional status predicted membership in the Subsyndromal versus the Resilient class.ConclusionsA variation in TNFA that was associated with Subsyndromal depressive symptoms in a sample of patients and their family caregivers was confirmed in this sample. Variations in cytokine genes may place these patients at higher risk for the development of Subsyndromal levels of depressive symptoms.
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- 2014
19. Identification of patient subgroups and risk factors for persistent arm/shoulder pain following breast cancer surgery
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Miaskowski, Christine, Paul, Steven M, Cooper, Bruce, West, Claudia, Levine, Jon D, Elboim, Charles, Hamolsky, Deborah, Abrams, Gary, Luce, Judith, Dhruva, Anand, Langford, Dale J, Merriman, John D, Kober, Kord, Baggott, Christina, Leutwyler, Heather, and Aouizerat, Bradley E
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Health Services and Systems ,Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Breast Cancer ,Clinical Research ,Patient Safety ,Cancer ,Chronic Pain ,Pain Research ,Rehabilitation ,Musculoskeletal ,Activities of Daily Living ,Arm ,Breast Neoplasms ,California ,Female ,Hand Strength ,Humans ,Longitudinal Studies ,Mastectomy ,Middle Aged ,Pain Measurement ,Pain ,Postoperative ,Prevalence ,Prospective Studies ,Quality of Life ,Range of Motion ,Articular ,Risk Factors ,Shoulder Pain ,Surveys and Questionnaires ,Arm pain ,Shoulder pain ,Persistent postsurgical pain ,Risk factors ,Breast cancer surgery ,Growth mixture modeling ,Latent class analysis ,Chronic pain ,Nursing ,Oncology and Carcinogenesis ,Oncology and carcinogenesis ,Health services and systems - Abstract
PurposeIn this prospective, longitudinal study, we extend our findings on persistent breast pain in patients (n = 398) following breast cancer surgery and evaluate the prevalence and characteristics of persistent pain in the arm/shoulder. In addition, differences in the severity of common symptoms and quality of life outcomes measured prior to surgery, among the arm pain classes, were evaluated.Methods and samplePatients were recruited from Breast Care Centers located in a Comprehensive Cancer Center, two public hospitals, and four community practices. Patients were assessed prior to and monthly for six months following breast cancer surgery.ResultsUsing growth mixture modeling, patients were classified into no (41.6%), mild (23.6%), and moderate (34.8%) arm pain classes based on ratings of worst arm/shoulder pain. Compared to the no pain class, patients in the moderate pain class were significantly younger, had a higher body mass index, and were more likely to report preoperative breast pain and swelling in the affected breast. In addition, patients in the moderate pain class reported higher levels of depression, anxiety, and sleep disturbance than the no pain class.ConclusionsFindings suggest that approximately 35% of women experience persistent levels of moderate arm/shoulder pain in the first six months following breast cancer surgery. Moderate arm/shoulder pain is associated with clinically meaningful decrements in functional status and quality of life.
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- 2014
20. Differences in the symptom experience of older oncology outpatients.
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Paul, Steven, Cooper, Bruce, Skerman, Helen, Merriman, John, Alexander, Kimberly, Yates, Patsy, Miaskowski, Christine, Aouizerat, Bradley, Cataldo, Janine, Dunn, Laura, and Ritchie, Christine
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Geriatric oncology ,cancer ,multiple concurrent symptoms ,symptom assessment ,symptom distress ,symptoms ,Age Factors ,Aged ,Australia ,Female ,Humans ,Longitudinal Studies ,Male ,Middle Aged ,Neoplasms ,Outpatients ,Prevalence ,Prospective Studies ,Severity of Illness Index ,United States - Abstract
CONTEXT: The relatively low number of older patients in cancer trials limits knowledge of how older adults experience symptoms associated with cancer and its treatment. OBJECTIVES: This study evaluated for differences in the symptom experience across four older age groups (60-64, 65-69, 70-74, ≥75 years). METHODS: Demographic, clinical, and symptom data from 330 patients aged >60 years who participated in one Australian and two U.S. studies were evaluated. The Memorial Symptom Assessment Scale was used to evaluate the occurrence, severity, frequency, and distress of 32 symptoms commonly associated with cancer and its treatment. RESULTS: On average, regardless of the age group, patients reported 10 concurrent symptoms. The most prevalent symptoms were physical in nature. Worrying was the most common psychological symptom. For 28 (87.5%) of the 32 Memorial Symptom Assessment Scale symptoms, no age-related differences were found in symptom occurrence rates. For symptom severity ratings, an age-related trend was found for difficulty swallowing. As age increased, severity of difficulty swallowing decreased. For symptom frequency, age-related trends were found for feeling irritable and diarrhea, with both decreasing in frequency as age increased. For symptom distress, age-related trends were found for lack of energy, shortness of breath, feeling bloated, and difficulty swallowing. As age increased, these symptoms received lower average distress ratings. CONCLUSION: Additional research is warranted to examine how age differences in symptom experience are influenced by treatment differences, aging-related changes in biological or psychological processes, or age-related response shift.
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- 2014
21. Preliminary evidence of an association between an interleukin 6 promoter polymorphism and self-reported attentional function in oncology patients and their family caregivers.
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Merriman, John, Aouizerat, Bradley, Langford, Dale, Cooper, Bruce, Baggott, Christina, Cataldo, Janine, Dhruva, Anand, Dunn, Laura, West, Claudia, Paul, Steven, Ritchie, Christine, Swift, Patrick, and Miaskowski, Christine
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attention ,cancer ,cytokines ,genetic association studies ,inflammation ,radiotherapy ,Aged ,Attention ,Caregivers ,Family ,Female ,Humans ,Interleukin-6 ,Male ,Middle Aged ,Neoplasms ,Polymorphism ,Single Nucleotide ,Promoter Regions ,Genetic - Abstract
Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare G allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.
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- 2014
22. Differences in the symptom experience of older oncology outpatients.
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Ritchie, Christine, Dunn, Laura B, Paul, Steven M, Cooper, Bruce A, Skerman, Helen, Merriman, John D, Aouizerat, Bradley, Alexander, Kimberly, Yates, Patsy, Cataldo, Janine, and Miaskowski, Christine
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Humans ,Neoplasms ,Severity of Illness Index ,Prevalence ,Longitudinal Studies ,Prospective Studies ,Age Factors ,Aged ,Middle Aged ,Outpatients ,United States ,Australia ,Female ,Male ,Geriatric oncology ,cancer ,multiple concurrent symptoms ,symptom assessment ,symptom distress ,symptoms ,Clinical Research ,Mind and Body ,Aging ,Clinical Trials and Supportive Activities ,Digestive Diseases ,Cancer ,Medical and Health Sciences ,Anesthesiology - Abstract
ContextThe relatively low number of older patients in cancer trials limits knowledge of how older adults experience symptoms associated with cancer and its treatment.ObjectivesThis study evaluated for differences in the symptom experience across four older age groups (60-64, 65-69, 70-74, ≥75 years).MethodsDemographic, clinical, and symptom data from 330 patients aged >60 years who participated in one Australian and two U.S. studies were evaluated. The Memorial Symptom Assessment Scale was used to evaluate the occurrence, severity, frequency, and distress of 32 symptoms commonly associated with cancer and its treatment.ResultsOn average, regardless of the age group, patients reported 10 concurrent symptoms. The most prevalent symptoms were physical in nature. Worrying was the most common psychological symptom. For 28 (87.5%) of the 32 Memorial Symptom Assessment Scale symptoms, no age-related differences were found in symptom occurrence rates. For symptom severity ratings, an age-related trend was found for difficulty swallowing. As age increased, severity of difficulty swallowing decreased. For symptom frequency, age-related trends were found for feeling irritable and diarrhea, with both decreasing in frequency as age increased. For symptom distress, age-related trends were found for lack of energy, shortness of breath, feeling bloated, and difficulty swallowing. As age increased, these symptoms received lower average distress ratings.ConclusionAdditional research is warranted to examine how age differences in symptom experience are influenced by treatment differences, aging-related changes in biological or psychological processes, or age-related response shift.
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- 2014
23. Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery.
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West, Claudia, Elboim, Charles, Paul, Steven, Cooper, Bruce, Leung, Geraldine, Schmidt, Brian, Merriman, John, Langford, Dale, Smoot, Betty, Miaskowski, Christine, Abrams, Gary, Baggott, Christina, Aouizerat, Bradley, Leutwyler, Heather, Neuhaus, John, Dhruva, Anand, and Kober, Kord
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Adult ,Aged ,Breast Neoplasms ,Cytokines ,Electric Impedance ,Female ,Genetic Predisposition to Disease ,Genotype ,Humans ,Lymphedema ,Mastectomy ,Middle Aged ,Oligonucleotide Array Sequence Analysis ,Polymorphism ,Single Nucleotide ,Surveys and Questionnaires - Abstract
BACKGROUND: Lymphedema (LE) is a frequent complication following breast cancer treatment. While progress is being made in the identification of phenotypic risk factors for the development of LE, little information is available on the molecular characterization of LE. The purpose of this study was to determine if variations in pro- and anti-inflammatory cytokine genes were associated with LE following breast cancer treatment. METHODS AND RESULTS: Breast cancer patients completed a number of self-report questionnaires. LE was evaluated using bioimpedance spectroscopy. Genotyping was done using a custom genotyping array. No differences were found between patients with (n=155) and without LE (n=387) for the majority of the demographic and clinical characteristics. Patients with LE had a significantly higher body mass index, more advanced disease, and a higher number of lymph nodes removed. Genetic associations were identified for three genes (i.e., interleukin (IL4) 4 (rs2227284), IL 10 (rs1518111), and nuclear kappa factor beta 2 (NFKB2 (rs1056890)) associated with inflammatory responses. CONCLUSIONS: These genetic associations suggest a role for a number of pro- and anti-inflammatory genes in the development of LE following breast cancer treatment.
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- 2014
24. Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery.
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Langford, Dale J, West, Claudia, Elboim, Charles, Cooper, Bruce A, Abrams, Gary, Paul, Steven M, Schmidt, Brian L, Levine, Jon D, Merriman, John D, Dhruva, Anand, Neuhaus, John, Leutwyler, Heather, Baggott, Christina, Sullivan, Carmen Ward, Aouizerat, Bradley E, and Miaskowski, Christine
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Humans ,Breast Neoplasms ,Pain ,Genetic Predisposition to Disease ,Potassium Channels ,Regression Analysis ,Genotype ,Polymorphism ,Single Nucleotide ,Adult ,Aged ,Middle Aged ,Female ,Young Adult ,Genetic Association Studies ,breast cancer ,breast pain ,candidate genes ,potassium channel genes ,preoperative pain ,Genetics ,Neurosciences ,Genetic Testing ,Pain Research ,Patient Safety ,Breast Cancer ,Clinical Research ,Cancer ,Chronic Pain ,Aetiology ,2.1 Biological and endogenous factors ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Preoperative breast pain in women with breast cancer may result from a number of causes. Previous work from our team found that breast pain occurred in 28.2% of women (n = 398) who were about to undergo breast cancer surgery. The occurrence of preoperative breast pain was associated with a number of demographic and clinical characteristics, as well as variation in two cytokine genes. Given that ion channels regulate excitability of sensory neurons, we hypothesized that variations in potassium channel genes would be associated with preoperative breast pain in these patients. Therefore, in this study, we evaluated for associations between single-nucleotide polymorphisms and inferred haplotypes among 10 potassium channel genes and the occurrence of preoperative breast pain in patients scheduled to undergo breast cancer surgery. Multivariable logistic regression analyses were used to identify those genetic variations that were associated with the occurrence of preoperative breast pain while controlling for age and genomic estimates of and self-reported race/ethnicity. Variations in four potassium channel genes: (1) potassium voltage-gated channel, delayed rectifier, subfamily S, member 1 (KCNS1); (2) potassium inwardly rectifying channel, subfamily J, member 3 (KCNJ3); (3) KCNJ6; and (4) potassium channel, subfamily K, member 9 (KCNK9) were associated with the occurrence of breast pain. Findings from this study warrant replication in an independent sample of women who report breast pain following one or more breast biopsies.
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- 2014
25. Associations between cytokine gene variations and self-reported sleep disturbance in women following breast cancer surgery.
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Langford, Dale, Koetters, Theresa, Merriman, John, West, Claudia, Alfaro, Emely, Paul, Steven, Cooper, Bruce, Hamolsky, Deborah, Elboim, Charles, Miaskowski, Christine, Aouizerat, Bradley, Cataldo, Janine, Dunn, Laura, Dhruva, Anand, and Kober, Kord
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Breast cancer ,Cytokine genes ,Growth mixture modeling ,Insomnia ,Sleep disturbance ,Symptom trajectories ,Adult ,Age Distribution ,Aged ,Breast Neoplasms ,Cytokines ,Female ,Genetic Variation ,Humans ,Incidence ,Interleukin-6 ,Logistic Models ,Longitudinal Studies ,Middle Aged ,Multivariate Analysis ,NF-kappa B p52 Subunit ,Phenotype ,Polymorphism ,Single Nucleotide ,Preoperative Care ,Risk Assessment ,Self Report ,Sleep Wake Disorders ,Surveys and Questionnaires - Abstract
PURPOSE OF THE RESEARCH: To attempt to replicate the associations found in our previous study of patients and family caregivers between interleukin 6 (IL6) and nuclear factor kappa beta 2 (NFKB2) and sleep disturbance and to identify additional genetic associations in a larger sample of patients with breast cancer. METHODS AND SAMPLE: Patients with breast cancer (n = 398) were recruited prior to surgery and followed for six months. Patients completed a self-report measure of sleep disturbance and provided a blood sample for genomic analyses. Growth mixture modeling was used to identify distinct latent classes of patients with higher and lower levels of sleep disturbance. KEY RESULTS: Patients who were younger and who had higher comorbidity and lower functional status were more likely to be in the high sustained sleep disturbance class. Variations in three cytokine genes (i.e., IL1 receptor 2 (IL1R2), IL13, NFKB2) predicted latent class membership. CONCLUSIONS: Polymorphisms in cytokine genes may partially explain inter-individual variability in sleep disturbance. Determination of high risk phenotypes and associated molecular markers may allow for earlier identification of patients at higher risk for developing sleep disturbance and lead to the development of more targeted clinical interventions.
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- 2014
26. Association between an interleukin 1 receptor, type I promoter polymorphism and self-reported attentional function in women with breast cancer
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Merriman, John D, Aouizerat, Bradley E, Cataldo, Janine K, Dunn, Laura, Cooper, Bruce A, West, Claudia, Paul, Steven M, Baggott, Christina R, Dhruva, Anand, Kober, Kord, Langford, Dale J, Leutwyler, Heather, Ritchie, Christine S, Abrams, Gary, Dodd, Marylin, Elboim, Charles, Hamolsky, Deborah, Melisko, Michelle, and Miaskowski, Christine
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Biomedical and Clinical Sciences ,Immunology ,Clinical Research ,Genetics ,Women's Health ,Cancer ,Aging ,Breast Cancer ,Behavioral and Social Science ,Aetiology ,2.1 Biological and endogenous factors ,Alleles ,Attention ,Breast Neoplasms ,Demography ,Female ,Genetic Association Studies ,Genetic Predisposition to Disease ,Heterozygote ,Homozygote ,Humans ,Logistic Models ,Middle Aged ,Models ,Biological ,Phenotype ,Polymorphism ,Single Nucleotide ,Promoter Regions ,Genetic ,Receptors ,Interleukin-1 Type I ,Self Report ,Breast cancer ,Inflammation ,Cytokine genes ,Interleukin 1 receptor ,type I ,AFI ,AIMs ,Attentional Function Index ,BIC ,BLRT ,BMI ,Bayesian information criterion ,CI ,CNS ,DNA ,GMM ,KPS ,Karnofsky Performance Status ,LD ,MAF ,OR ,SCQ ,SNP ,Self-administered Comorbidity Questionnaire ,VLMR ,Vuong-Lo-Mendell-Rubin likelihood ratio test ,ancestry informative markers ,body mass index ,bootstrapped likelihood ratio test ,central nervous system ,confidence interval ,deoxyribonucleic acid ,growth mixture modeling ,linkage disequilibrium ,minor allele frequency ,odds ratio ,single nucleotide polymorphism ,Biochemistry and Cell Biology - Abstract
Subgroups of patients with breast cancer may be at greater risk for cytokine-induced changes in cognitive function after diagnosis and during treatment. The purposes of this study were to identify subgroups of patients with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) predictors of subgroup membership. Self-reported attentional function was evaluated in 397 patients with breast cancer using the Attentional Function Index before surgery and for six months after surgery (i.e., seven time points). Using growth mixture modeling, three attentional function latent classes were identified: High (41.6%), Moderate (25.4%), and Low-moderate (33.0%). Patients in the Low-moderate class were significantly younger than those in the High class, with more comorbidities and lower functional status than the other two classes. No differences were found among the classes in years of education, race/ethnicity, or other clinical characteristics. DNA was recovered from 302 patients' samples. Eighty-two single nucleotide polymorphisms among 15 candidate genes were included in the genetic association analyses. After controlling for age, comorbidities, functional status, and population stratification due to race/ethnicity, IL1R1 rs949963 remained a significant genotypic predictor of class membership in the multivariable model. Carrying the rare "A" allele (i.e., GA+AA) was associated with a twofold increase in the odds of belonging to a lower attentional function class (OR: 1.98; 95% CI: 1.18, 3.30; p=.009). Findings provide evidence of subgroups of women with breast cancer who report distinct trajectories of attentional function and of a genetic association between subgroup membership and an IL1R1 promoter polymorphism.
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- 2014
27. Associations Between Cytokine Gene Variations and Severe Persistent Breast Pain in Women Following Breast Cancer Surgery
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Stephens, Kimberly, Cooper, Bruce A, West, Claudia, Paul, Steven M, Baggott, Christina R, Merriman, John D, Dhruva, Anand, Kober, Kord M, Langford, Dale J, Leutwyler, Heather, Luce, Judith A, Schmidt, Brian L, Abrams, Gary M, Elboim, Charles, Hamolsky, Deborah, Levine, Jon D, Miaskowski, Christine, and Aouizerat, Bradley E
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Health Sciences ,Cancer ,Chronic Pain ,Breast Cancer ,Genetics ,Pain Research ,Aetiology ,2.1 Biological and endogenous factors ,Breast ,Breast Neoplasms ,Cytokines ,Female ,Genotyping Techniques ,Haplotypes ,Humans ,Interleukin-10 ,Linkage Disequilibrium ,Logistic Models ,Longitudinal Studies ,Mastectomy ,Middle Aged ,Pain Measurement ,Pain ,Postoperative ,Phenotype ,Polymorphism ,Single Nucleotide ,Receptors ,Interleukin-1 Type II ,Severity of Illness Index ,Surveys and Questionnaires ,polymorphism ,breast cancer surgery ,candidate genes ,persistent pain ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Anesthesiology ,Clinical sciences ,Epidemiology - Abstract
UnlabelledPersistent pain following breast cancer surgery is a significant clinical problem. Although immune mechanisms may play a role in the development and maintenance of persistent pain, few studies have evaluated for associations between persistent breast pain following breast cancer surgery and variations in cytokine genes. In this study, associations between previously identified extreme persistent breast pain phenotypes (ie, no pain vs severe pain) and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated. In unadjusted analyses, the frequency of 13 SNPs and 3 haplotypes in 7 genes differed significantly between the no pain and severe pain classes. After adjustment for preoperative breast pain and the severity of average postoperative pain, 1 SNP (ie, interleukin [IL] 1 receptor 2 rs11674595) and 1 haplotype (ie, IL10 haplotype A8) were associated with pain group membership. These findings suggest a role for cytokine gene polymorphisms in the development of persistent breast pain following breast cancer surgery.PerspectiveThis study evaluated for associations between cytokine gene variations and the severity of persistent breast pain in women following breast cancer surgery. Variations in 2 cytokine genes were associated with severe breast pain. The results suggest that cytokines play a role in the development of persistent postsurgical pain.
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- 2014
28. Associations between cytokine gene variations and self-reported sleep disturbance in women following breast cancer surgery.
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Alfaro, Emely, Dhruva, Anand, Langford, Dale J, Koetters, Theresa, Merriman, John D, West, Claudia, Dunn, Laura B, Paul, Steven M, Cooper, Bruce, Cataldo, Janine, Hamolsky, Deborah, Elboim, Charles, Kober, Kord, Aouizerat, Bradley E, and Miaskowski, Christine
- Subjects
Humans ,Breast Neoplasms ,Interleukin-6 ,Cytokines ,Preoperative Care ,Incidence ,Multivariate Analysis ,Logistic Models ,Risk Assessment ,Longitudinal Studies ,Age Distribution ,Phenotype ,Polymorphism ,Single Nucleotide ,Adult ,Aged ,Middle Aged ,Female ,NF-kappa B p52 Subunit ,Genetic Variation ,Self Report ,Surveys and Questionnaires ,Sleep Wake Disorders ,Breast cancer ,Cytokine genes ,Growth mixture modeling ,Insomnia ,Sleep disturbance ,Symptom trajectories ,Nursing ,Oncology and Carcinogenesis - Abstract
Purpose of the researchTo attempt to replicate the associations found in our previous study of patients and family caregivers between interleukin 6 (IL6) and nuclear factor kappa beta 2 (NFKB2) and sleep disturbance and to identify additional genetic associations in a larger sample of patients with breast cancer.Methods and samplePatients with breast cancer (n = 398) were recruited prior to surgery and followed for six months. Patients completed a self-report measure of sleep disturbance and provided a blood sample for genomic analyses. Growth mixture modeling was used to identify distinct latent classes of patients with higher and lower levels of sleep disturbance.Key resultsPatients who were younger and who had higher comorbidity and lower functional status were more likely to be in the high sustained sleep disturbance class. Variations in three cytokine genes (i.e., IL1 receptor 2 (IL1R2), IL13, NFKB2) predicted latent class membership.ConclusionsPolymorphisms in cytokine genes may partially explain inter-individual variability in sleep disturbance. Determination of high risk phenotypes and associated molecular markers may allow for earlier identification of patients at higher risk for developing sleep disturbance and lead to the development of more targeted clinical interventions.
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- 2014
29. Differences in morning and evening fatigue in oncology patients and their family caregivers.
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Cooper, Bruce, Paul, Steven, West, Claudia, Langford, Dale, Merriman, John, Miaskowski, Christine, Baggott, Christina, Aouizerat, Bradley, Lee, Kathryn, Leutwyler, Heather, Cataldo, Janine, Dunn, Laura, Ritchie, Christine, Dhruva, Anand, Dodd, Marylin, Wara, William, and Kober, Kord
- Subjects
Cancer treatment ,Diurnal variability ,Evening fatigue ,Fatigue ,Growth mixture modeling ,Latent class analysis ,Morning fatigue ,Radiation therapy ,Adult ,Age Factors ,Aged ,Ambulatory Care ,Ambulatory Care Facilities ,Analysis of Variance ,Cancer Care Facilities ,Caregivers ,Chi-Square Distribution ,Circadian Rhythm ,Fatigue ,Female ,Humans ,Longitudinal Studies ,Male ,Middle Aged ,Neoplasms ,Risk Assessment ,Severity of Illness Index ,Sex Factors - Abstract
PURPOSE OF THE RESEARCH: To identify distinct latent classes of individuals based on ratings of morning and evening fatigue; evaluate for differences in phenotypic characteristics, as well as symptom and quality of life scores, among these latent classes; and evaluate for an overlap in morning and evening fatigue class membership. PATIENTS AND METHODS: In a sample of 167 oncology outpatients and 85 of their FCs, growth mixture modeling was used to identify distinct latent classes based on ratings of morning and evening fatigue obtained before, during, and after radiation therapy. Analyses of variance and Chi Square analyses were used to evaluate for differences among the morning and evening fatigue latent classes. RESULTS: Three distinct latent classes for morning fatigue were identified. Participants in the High Morning Fatigue class (47%) were younger and had lower functional status. Three distinct latent classes for evening fatigue were identified. Participants in the High Evening Fatigue class (61%) were younger, more likely to be female, more likely to have children at home, and more likely to be a FC. Only 10.3% of participants were classified in both the Very Low Morning and Low Evening Fatigue classes and 41.3% were classified in both the High Morning and High Evening Fatigue classes. CONCLUSIONS: Different characteristics were associated with morning and evening fatigue, which suggests that morning and evening fatigue may be distinct but related symptoms. Additional research is needed to elucidate the mechanisms that may underlie diurnal variability in fatigue.
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- 2013
30. Differences in morning and evening fatigue in oncology patients and their family caregivers.
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Dhruva, Anand, Aouizerat, Bradley E, Cooper, Bruce, Paul, Steven M, Dodd, Marylin, West, Claudia, Wara, William, Lee, Kathryn, Dunn, Laura B, Langford, Dale J, Merriman, John D, Baggott, Christina, Cataldo, Janine, Ritchie, Christine, Kober, Kord, Leutwyler, Heather, and Miaskowski, Christine
- Subjects
Humans ,Neoplasms ,Fatigue ,Ambulatory Care ,Severity of Illness Index ,Analysis of Variance ,Risk Assessment ,Chi-Square Distribution ,Longitudinal Studies ,Age Factors ,Sex Factors ,Circadian Rhythm ,Adult ,Aged ,Middle Aged ,Caregivers ,Ambulatory Care Facilities ,Cancer Care Facilities ,Female ,Male ,Cancer treatment ,Diurnal variability ,Evening fatigue ,Growth mixture modeling ,Latent class analysis ,Morning fatigue ,Radiation therapy ,Cancer ,Nursing ,Oncology and Carcinogenesis - Abstract
Purpose of the researchTo identify distinct latent classes of individuals based on ratings of morning and evening fatigue; evaluate for differences in phenotypic characteristics, as well as symptom and quality of life scores, among these latent classes; and evaluate for an overlap in morning and evening fatigue class membership.Patients and methodsIn a sample of 167 oncology outpatients and 85 of their FCs, growth mixture modeling was used to identify distinct latent classes based on ratings of morning and evening fatigue obtained before, during, and after radiation therapy. Analyses of variance and Chi Square analyses were used to evaluate for differences among the morning and evening fatigue latent classes.ResultsThree distinct latent classes for morning fatigue were identified. Participants in the High Morning Fatigue class (47%) were younger and had lower functional status. Three distinct latent classes for evening fatigue were identified. Participants in the High Evening Fatigue class (61%) were younger, more likely to be female, more likely to have children at home, and more likely to be a FC. Only 10.3% of participants were classified in both the Very Low Morning and Low Evening Fatigue classes and 41.3% were classified in both the High Morning and High Evening Fatigue classes.ConclusionsDifferent characteristics were associated with morning and evening fatigue, which suggests that morning and evening fatigue may be distinct but related symptoms. Additional research is needed to elucidate the mechanisms that may underlie diurnal variability in fatigue.
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- 2013
31. Proposed mechanisms for cancer- and treatment-related cognitive changes.
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Merriman, John D, Von Ah, Diane, Miaskowski, Christine, and Aouizerat, Bradley E
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Humans ,Neoplasms ,Antineoplastic Agents ,Cognition ,cancer ,cytokines ,inflammation ,neurotransmitters ,Hematology ,Behavioral and Social Science ,Cancer ,Genetics ,Clinical Research ,Neurosciences ,Mind and Body ,Aetiology ,2.1 Biological and endogenous factors ,Nursing ,Oncology and Carcinogenesis - Abstract
ObjectivesTo review the proposed mechanisms of cognitive changes associated with non-central nervous system cancers and cancer treatment.Data sourcesReview and synthesis of databased publications and review articles.ConclusionProposed mechanisms include cytokine upregulation, hormonal changes, neurotransmitter dysregulation, attentional fatigue, genetic predisposition, and comorbid symptoms.Implications for nursing practiceOncology nurses need to understand the multiple mechanisms that may contribute to the development of cancer- and treatment-related cognitive changes so that they can identify patients at high risk and help patients understand why these changes occur.
- Published
- 2013
32. The Dynamite Club
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Merriman, John M., primary
- Published
- 2020
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33. Waiting for “Nodough”: The Future of Service Charges
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Merriman, John, primary, Tonkery, Dan, additional, and Merryman, Margaret M., additional
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- 2019
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34. Assessment and Management of Cancer- and Cancer Treatment–Related Cognitive Impairment
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Allen, Deborah H., Myers, Jamie S., Jansen, Catherine E., Merriman, John D., and Von Ah, Diane
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- 2018
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35. Cytokine gene variation is associated with depressive symptom trajectories in oncology patients and family caregivers.
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Dunn, Laura, Aouizerat, Bradley, Langford, Dale, Cooper, Bruce, Dhruva, Anand, Cataldo, Janine, Baggott, Christina, Merriman, John, Dodd, Marylin, West, Claudia, Paul, Steven, and Miaskowski, Christine
- Subjects
Adult ,Age Distribution ,Aged ,California ,Caregivers ,Cohort Studies ,Comorbidity ,Cytokines ,Depression ,Female ,Follow-Up Studies ,Genetic Predisposition to Disease ,Genetic Variation ,Genotype ,Humans ,Incidence ,Logistic Models ,Male ,Medical Oncology ,Middle Aged ,Multivariate Analysis ,Neoplasms ,Phenotype ,Polymorphism ,Single Nucleotide ,Severity of Illness Index ,Sex Distribution - Abstract
PURPOSE: Depressive symptoms are common in cancer patients and their family caregivers (FCs). While these symptoms are characterized by substantial interindividual variability, the factors that predict this variability remain largely unknown. This study sought to confirm latent classes of oncology patients and FCs with distinct depressive symptom trajectories and to examine differences in phenotypic and genotypic characteristics among these classes. METHOD: Among 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their FCs, growth mixture modeling (GMM) was used to identify latent classes of individuals based on Center for Epidemiological Studies-Depression (CES-D) scores obtained prior to, during, and for four months following completion of radiation therapy. One hundred four single nucleotide polymorphisms (SNPs) and haplotypes in 15 candidate cytokine genes were interrogated for differences between the two largest latent classes. Multivariate logistic regression analyses assessed effects of phenotypic and genotypic characteristics on class membership. RESULTS: Four latent classes were confirmed: Resilient (56.3%), Subsyndromal (32.5%), Delayed (5.2%), and Peak (6.0%). Participants who were younger, female, non-white, and who reported higher baseline trait and state anxiety were more likely to be in the Subsyndromal, Delayed, or Peak groups. Variation in three cytokine genes (i.e., interleukin 1 receptor 2 [IL1R2], IL10, tumor necrosis factor alpha [TNFA]), age, and performance status predicted membership in the Resilient versus Subsyndromal classes. CONCLUSIONS: Findings confirm the four latent classes of depressive symptom trajectories previously identified in a sample of breast cancer patients. Variations in cytokine genes may influence variability in depressive symptom trajectories.
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- 2013
36. Differences in the symptom experience of older versus younger oncology outpatients: a cross-sectional study
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Cataldo, Janine K, Paul, Steven, Cooper, Bruce, Skerman, Helen, Alexander, Kimberly, Aouizerat, Bradley, Blackman, Virginia, Merriman, John, Dunn, Laura, Ritchie, Christine, Yates, Patsy, and Miaskowski, Christine
- Abstract
Abstract Background Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may be that older patients received substandard treatment because of concerns about adverse effects. Given the paucity of research on the multiple dimensions of the symptom experience in older oncology patients, the purpose of this study was to evaluate for differences in ratings of symptom occurrence, severity, frequency, and distress between younger (< 60 years) and older ( ≥ 60 years) adults undergoing cancer treatment. We hypothesized that older patients would have significantly lower ratings on four symptom dimensions. Methods Data from two studies in the United States and one study in Australia were combined to conduct this analysis. All three studies used the MSAS to evaluate the occurrence, severity, frequency, and distress of 32 symptoms. Results Data from 593 oncology outpatients receiving active treatment for their cancer (i.e., 44.4% were
- Published
- 2013
37. Identification of patient subgroups and risk factors for persistent breast pain following breast cancer surgery.
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Cooper, Bruce, Paul, Steven, West, Claudia, Langford, Dale, Hamolsky, Deborah, Schmidt, Brian, Merriman, John, Miaskowski, Christine, Abrams, Gary, Baggott, Christina, Aouizerat, Bradley, Neuhaus, John, Cataldo, Janine, Dunn, Laura, Levine, Jon, Dhruva, Anand, and Dodd, Marylin
- Subjects
Adult ,Aged ,Breast Neoplasms ,Female ,Humans ,Longitudinal Studies ,Mastodynia ,Middle Aged ,Pain Measurement ,Pain ,Postoperative ,Prospective Studies ,Risk Factors ,Surveys and Questionnaires - Abstract
UNLABELLED: Study purposes were to determine the prevalence of persistent pain in the breast; characterize distinct persistent pain classes using growth mixture modeling; and evaluate for differences among these pain classes in demographic, preoperative, intraoperative, and postoperative characteristics. In addition, differences in the severity of common symptoms and quality of life outcomes measured prior to surgery, among the pain classes, were evaluated. Patients (n = 398) were recruited prior to surgery and followed for 6 months. Using growth mixture modeling, patients were classified into no (31.7%), mild (43.4%), moderate (13.3%), and severe (11.6%) pain groups based on ratings of worst breast pain. Differences in a number of demographic, preoperative, intraoperative, and postoperative characteristics differentiated among the pain classes. In addition, patients in the moderate and severe pain classes reported higher preoperative levels of depression, anxiety, and sleep disturbance than the no pain class. Findings suggest that approximately 25% of women experience significant and persistent levels of breast pain in the first 6 months following breast cancer surgery. PERSPECTIVE: Persistent pain is a significant problem for 25% of women following surgery for breast cancer. Severe breast pain is associated with clinically meaningful decrements in functional status and quality of life.
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- 2012
38. Identification of patient subgroups and risk factors for persistent breast pain following breast cancer surgery.
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Miaskowski, Christine, Cooper, Bruce, Paul, Steven M, West, Claudia, Langford, Dale, Levine, Jon D, Abrams, Gary, Hamolsky, Deborah, Dunn, Laura, Dodd, Marylin, Neuhaus, John, Baggott, Christina, Dhruva, Anand, Schmidt, Brian, Cataldo, Janine, Merriman, John, and Aouizerat, Bradley E
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Humans ,Breast Neoplasms ,Pain ,Postoperative ,Pain Measurement ,Risk Factors ,Longitudinal Studies ,Prospective Studies ,Adult ,Aged ,Middle Aged ,Female ,Mastodynia ,Surveys and Questionnaires ,Breast Cancer ,Rehabilitation ,Cancer ,Chronic Pain ,Clinical Research ,Pain Research ,Patient Safety ,Breast pain ,persistent postsurgical pain ,risk factors ,breast cancer surgery ,growth mixture modeling ,latent class analysis ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Anesthesiology - Abstract
UnlabelledStudy purposes were to determine the prevalence of persistent pain in the breast; characterize distinct persistent pain classes using growth mixture modeling; and evaluate for differences among these pain classes in demographic, preoperative, intraoperative, and postoperative characteristics. In addition, differences in the severity of common symptoms and quality of life outcomes measured prior to surgery, among the pain classes, were evaluated. Patients (n = 398) were recruited prior to surgery and followed for 6 months. Using growth mixture modeling, patients were classified into no (31.7%), mild (43.4%), moderate (13.3%), and severe (11.6%) pain groups based on ratings of worst breast pain. Differences in a number of demographic, preoperative, intraoperative, and postoperative characteristics differentiated among the pain classes. In addition, patients in the moderate and severe pain classes reported higher preoperative levels of depression, anxiety, and sleep disturbance than the no pain class. Findings suggest that approximately 25% of women experience significant and persistent levels of breast pain in the first 6 months following breast cancer surgery.PerspectivePersistent pain is a significant problem for 25% of women following surgery for breast cancer. Severe breast pain is associated with clinically meaningful decrements in functional status and quality of life.
- Published
- 2012
39. Evidence of associations between cytokine genes and subjective reports of sleep disturbance in oncology patients and their family caregivers.
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Miaskowski, Christine, Cooper, Bruce A, Dhruva, Anand, Dunn, Laura B, Langford, Dale J, Cataldo, Janine K, Baggott, Christina R, Merriman, John D, Dodd, Marylin, Lee, Kathryn, West, Claudia, Paul, Steven M, and Aouizerat, Bradley E
- Subjects
Humans ,Neoplasms ,Cytokines ,Models ,Statistical ,Regression Analysis ,Polymorphism ,Single Nucleotide ,Middle Aged ,Caregivers ,Female ,Male ,Self Report ,Sleep Wake Disorders ,Sleep Research ,Genetics ,Cancer ,Aetiology ,2.1 Biological and endogenous factors ,General Science & Technology - Abstract
The purposes of this study were to identify distinct latent classes of individuals based on subjective reports of sleep disturbance; to examine differences in demographic, clinical, and symptom characteristics between the latent classes; and to evaluate for variations in pro- and anti-inflammatory cytokine genes between the latent classes. Among 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their FCs, growth mixture modeling (GMM) was used to identify latent classes of individuals based on General Sleep Disturbance Scale (GSDS) obtained prior to, during, and for four months following completion of radiation therapy. Single nucleotide polymorphisms (SNPs) and haplotypes in candidate cytokine genes were interrogated for differences between the two latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on GSDS group membership. Two latent classes were identified: lower sleep disturbance (88.5%) and higher sleep disturbance (11.5%). Participants who were younger and had a lower Karnofsky Performance status score were more likely to be in the higher sleep disturbance class. Variation in two cytokine genes (i.e., IL6, NFKB) predicted latent class membership. Evidence was found for latent classes with distinct sleep disturbance trajectories. Unique genetic markers in cytokine genes may partially explain the interindividual heterogeneity characterizing these trajectories.
- Published
- 2012
40. Opening the Gates: The Lip Affair, 1968-1981
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Merriman, John
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Opening the Gates: The Lip Affair, 1968-1981 (Nonfiction work) -- Reid, Donald -- Book reviews ,Books -- Book reviews ,History - Abstract
Opening the Gales: The Lip Affair, 1968-1981. By Donald Reid. (London, UK: Verso, 2018. Pp. xvi, 492. $60.00.) When the Lip watchmaking company in Besancon declared bankruptcy in April 1973, [...]
- Published
- 2019
41. Complex Care Needs at the End of Life for Seriously Ill Adults With Multiple Chronic Conditions
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Murali, Komal Patel, primary, Merriman, John D., additional, Yu, Gary, additional, Vorderstrasse, Allison, additional, Kelley, Amy S., additional, and Brody, Abraham A., additional
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- 2023
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42. Community Navigation and Supportive Care Experiences of Low-Income Black and Latina Cancer Survivors: Patient and Navigator Perspectives
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Mazor, Melissa, David, Daniel, Moorehead, Dolores, Merriman, John D., and Lin, Jenny J.
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Article - Abstract
BACKGROUND: Little is known about the role of community-based navigation in supportive care delivery for historically marginalized cancer survivors. The purposes of this study were to evaluate supportive care experiences of low-income, Black and Latina cancer survivors and examine the care role of their community navigator. METHODS: Qualitative evaluation of semi-structured interviews with Black and Latina cancer survivors (n=10) and navigators (n=4) from a community-based organization for low-income women were conducted and analyzed using content analysis. RESULTS: Content analysis yielded six themes that described the supportive care experience over time and before and after navigator support. Navigating supportive care alone: a) internal and external influencers; b) alone and just surviving; c) feeling overwhelmed and distressed. Community Navigator delivered supportive care: a) establishing trust and safety; b) accepting multi-dimensional, navigator assisted supportive care management; c) distress alleviation. CONCLUSIONS: Low-income Black and Latina women with cancer reported internal strength yet endured cancer care alone leading to a feeling of distress. Subsequently, community navigators provided patient-centric, supportive care and alleviate physical and emotional distress. These findings highlight the importance of increasing awareness of and linkage to community navigators who may be able to meet the supportive care needs of diverse patient populations.
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- 2023
43. The Spectre of the Commune and French Anarchism in the 1890s
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Merriman, John, primary
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- 2018
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44. Profiles of Work and Quality of Life among Young Adult Cancer Survivors
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Ghazal, Lauren V., primary, Merriman, John D., additional, Santacroce, Sheila J., additional, Fletcher, Jason, additional, Wright, Fay, additional, and Dickson, Victoria Vaughan, additional
- Published
- 2022
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45. Immigrants Needs in Cancer Palliative Care: A Scoping Review Protocol
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Park, Jae, Merriman, John, Wu, Bei, Campbell, Brynne, and Schulman-Green, Dena
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- 2022
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46. Exploration of Relationships Between Symptoms, Work Characteristics, and Quality of Life in Young Adult Hematologic Cancer Survivors
- Author
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Ghazal, Lauren V., primary, Merriman, John D., additional, Santacroce, Sheila J., additional, Fletcher, Jason, additional, Wright, Fay, additional, and Dickson, Victoria Vaughan, additional
- Published
- 2022
- Full Text
- View/download PDF
47. The association between pre-treatment occupational skill level and mood and symptom burden in early-stage, postmenopausal breast cancer survivors during the first year of anastrozole therapy
- Author
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Nugent, Bethany D., Sereika, Susan M., Rosenzweig, Margaret, McCue, Michael, Merriman, John D., and Bender, Catherine M.
- Published
- 2016
- Full Text
- View/download PDF
48. Trajectories of self‐reported cognitive function in postmenopausal women during adjuvant systemic therapy for breast cancer
- Author
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Merriman, John D., Sereika, Susan M., Brufsky, Adam M., McAuliffe, Priscilla F., McGuire, Kandace P., Myers, Jamie S., Phillips, Mary L., Ryan, Christopher M., Gentry, Amanda L., Jones, Lindsay D., and Bender, Catherine M.
- Published
- 2017
- Full Text
- View/download PDF
49. History on the Margins : People and Places in the Emergence of Modern France
- Author
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MERRIMAN, JOHN and MERRIMAN, JOHN
- Published
- 2018
50. Profiles of Work and Quality of Life among Young Adult Cancer Survivors.
- Author
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Ghazal, Lauren V., Merriman, John D., Santacroce, Sheila J., Fletcher, Jason, Wright, Fay, and Dickson, Victoria Vaughan
- Subjects
- *
BEHAVIORAL research , *WORK , *RESEARCH methodology , *TIME , *SELF-evaluation , *SELF-perception , *CROSS-sectional method , *INTERVIEWING , *ECOLOGICAL research , *CANCER patients , *ABILITY , *T-test (Statistics) , *QUALITY of life , *HEMATOLOGIC malignancies , *QUESTIONNAIRES , *DATA analysis software , *GOAL (Psychology) - Abstract
Work ability, or the perception of one's ability to work presently and in the future, may impact quality of life (QOL) among young adult (YA) cancer survivors. Through a convergent mixed methods design, we explored work ability, work-related goals, and QOL among YA hematologic cancer survivors within five years of diagnosis. We described associations at the individual- and microsystem (work)- levels; and compared factors across low and high work ability groups. Participants (N = 40) completed a survey and interview via digital platforms. Qualitative analysis revealed self-assessed declines in work ability led to questioning work-related goals and influenced QOL. Integrated analysis led to the development of four profiles, growing our understanding of work's influence on QOL for YA cancer survivors, and identifying components YAs considered when contemplating work-related goals after a cancer diagnosis. Larger studies are needed to elucidate these profiles and identify modifiable factors to inform targeted interventions to improve QOL. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
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