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3. Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching

Author

Skriver, Karen, primary, Sjørup, Signe A., additional, Langkilde, Annette E., additional, Balouka, Evanthia, additional, Christensen, Caspar S., additional, Carbel, Kathrine, additional, Decker, Jens N. V., additional, Essenbæk, David N., additional, Gräf, Justus F., additional, Jessen, Camilla H., additional, Kristensen, Peter, additional, Merrild, Christoffer, additional, Mortensen, Tobias S., additional, Nalepa, Isabella F., additional, Nordsteen, Bjørn W., additional, Svoren, Sophie K., additional, van Hall, Matthijs, additional, Weicher, Jan, additional, Wind, Malene L., additional, Zhang, Danping, additional, Saar, Daniel, additional, Blæsild, Helle, additional, Stahlhut, Martin, additional, Andersen, Kim V., additional, Dagil, Robert, additional, Vestergaard, Bente, additional, Ryberg, Marie L., additional, and Kragelund, Birthe B., additional

Published
2023
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4. Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching

Author

Skriver, Karen, Sjørup, Signe A., Langkilde, Annette E., Balouka, Evanthia, Christensen, Casper S., Carbel, Kathrine, Decker, Jens N. V., Essenbæk, David N., Gräf, Justus F., Jessen, Camilla H., Kristensen, Peter, Merrild, Christoffer, Mortensen, Tobias S., Nalepa, Isabella F., Nordsteen, Bjørn W., Svoren, Sophie K., van Hall, Matthijs, Weicher, Jan, Wind, Malene L., Zhang, Danping, Saar, Daniel, Blæsild, Helle, Stahlhut, Martin, Andersen, Kim V., Dagil, Robert, Vestergaard, Bente, Ryberg, Marie L., Kragelund, Birthe B., Skriver, Karen, Sjørup, Signe A., Langkilde, Annette E., Balouka, Evanthia, Christensen, Casper S., Carbel, Kathrine, Decker, Jens N. V., Essenbæk, David N., Gräf, Justus F., Jessen, Camilla H., Kristensen, Peter, Merrild, Christoffer, Mortensen, Tobias S., Nalepa, Isabella F., Nordsteen, Bjørn W., Svoren, Sophie K., van Hall, Matthijs, Weicher, Jan, Wind, Malene L., Zhang, Danping, Saar, Daniel, Blæsild, Helle, Stahlhut, Martin, Andersen, Kim V., Dagil, Robert, Vestergaard, Bente, Ryberg, Marie L., and Kragelund, Birthe B.

Abstract

Integrating research and teaching in a meaningful manner is a challenge. With the growing number of students in universities and the rapid advances and innovations across many fields and technologies, the one-on-one mentor relationship seems utopia. However, increasing demands for inquiry-competent problem-solvers and the expanding integrative nature of science require a rethinking of teaching styles. Using the intrinsically disordered proteins (IDPs) as an instrument for research-integrating teaching, we have developed a teaching platform, which provides research opportunities for both students and researchers. The unpredictable and dynamic, but technically manageable character of IDPs offers an opportunity for open- ended processes of inquiry that are key to both learning and research. Organizing a course around a dynamic scientific field allowed the students to take active part in exploring and developing knowledge about scientific problems of interest to academia and industries. These experiences of exploring IDPs offer concrete ideas on how to organize courses in ways that integrate research and teaching.

Published
2023

6. When gluttony strikes: how high‐fat diet impairs hepatic Ca2+ signalling.

Author

Merrild, Christoffer and Johansen, Valdemar Brimnes Ingemann

Subjects
*HIGH-fat diet, *FATTY liver, *LEPTIN, *CALCIUM ions
Abstract

Looking ahead In summary, the authors demonstrated that HFD hepatocytes required a 10-fold higher NA concentration to obtain the half-maximal effective concentration of NA-stimulated cytosolic Ca SP 2+ sp signalling compared to LFD hepatocytes (Fig. Keywords: calcium imaging; calcium signalling; high fat diet; in vivo; metabolism; NAFLD; NASH; obesity EN calcium imaging calcium signalling high fat diet in vivo metabolism NAFLD NASH obesity 2245 2247 3 06/19/23 20230615 NES 230615 Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of metabolic syndrome (Lazarus et al., [5]), and end-stage NAFLD, an inflammatory disease, is known as non-alcoholic steatohepatitis (NASH). The frequency of cytosolic calcium oscillations was lower in primary HFD hepatocytes compared to LFD hepatocytes, and the latter had significantly fewer calcium misfiring spikes in the oscillatory signalling train, although the shape of each spike, i.e. full width at half maximum, was unchanged (Brumer et al., [2]). [Extracted from the article]

Published
2023
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