Search

Your search keyword '"Merone, Rossella"' showing total 12 results
Start Over Author "Merone, Rossella"
12 results on '"Merone, Rossella"'

1. Development of a Potency Assay for Nous-209, a Multivalent Neoantigens-Based Genetic Cancer Vaccine

Author

Bartolomeo, Rosa, primary, Troise, Fulvia, additional, Allocca, Simona, additional, Sdruscia, Giulia, additional, Vitale, Rosa, additional, Bignone, Veronica, additional, Petrone, Anna Maria, additional, Romano, Giuseppina, additional, D’Alise, Anna Morena, additional, Ruzza, Valentino, additional, Garzia, Irene, additional, Leoni, Guido, additional, Merone, Rossella, additional, Lanzaro, Francesca, additional, Colloca, Stefano, additional, Siani, Loredana, additional, Scarselli, Elisa, additional, and Cotugno, Gabriella, additional

Published
2024
Full Text
View/download PDF

2. Table S1 from A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability

Author

Leoni, Guido, primary, D'Alise, Anna Morena, primary, Cotugno, Gabriella, primary, Langone, Francesca, primary, Garzia, Irene, primary, De Lucia, Maria, primary, Fichera, Imma, primary, Vitale, Rosa, primary, Bignone, Veronica, primary, Tucci, Fabio Giovanni, primary, Mori, Federica, primary, Leuzzi, Adriano, primary, Di Matteo, Elena, primary, Troise, Fulvia, primary, Abbate, Adele, primary, Merone, Rossella, primary, Ruzza, Valentino, primary, Diodoro, Maria Grazia, primary, Yadav, Mahesh, primary, Gordon-Alonso, Monica, primary, Vanhaver, Cristophe, primary, Panigada, Maddalena, primary, Soprana, Elisa, primary, Siccardi, Antonio, primary, Folgori, Antonella, primary, Colloca, Stefano, primary, van der Bruggen, Pierre, primary, Nicosia, Alfredo, primary, Lahm, Armin, primary, Catanese, Maria Teresa, primary, and Scarselli, Elisa, primary

Published
2023
Full Text
View/download PDF

3. Data from A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability

Author

Leoni, Guido, primary, D'Alise, Anna Morena, primary, Cotugno, Gabriella, primary, Langone, Francesca, primary, Garzia, Irene, primary, De Lucia, Maria, primary, Fichera, Imma, primary, Vitale, Rosa, primary, Bignone, Veronica, primary, Tucci, Fabio Giovanni, primary, Mori, Federica, primary, Leuzzi, Adriano, primary, Di Matteo, Elena, primary, Troise, Fulvia, primary, Abbate, Adele, primary, Merone, Rossella, primary, Ruzza, Valentino, primary, Diodoro, Maria Grazia, primary, Yadav, Mahesh, primary, Gordon-Alonso, Monica, primary, Vanhaver, Cristophe, primary, Panigada, Maddalena, primary, Soprana, Elisa, primary, Siccardi, Antonio, primary, Folgori, Antonella, primary, Colloca, Stefano, primary, van der Bruggen, Pierre, primary, Nicosia, Alfredo, primary, Lahm, Armin, primary, Catanese, Maria Teresa, primary, and Scarselli, Elisa, primary

Published
2023
Full Text
View/download PDF

4. Supplementary Data from A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability

Author

Leoni, Guido, primary, D'Alise, Anna Morena, primary, Cotugno, Gabriella, primary, Langone, Francesca, primary, Garzia, Irene, primary, De Lucia, Maria, primary, Fichera, Imma, primary, Vitale, Rosa, primary, Bignone, Veronica, primary, Tucci, Fabio Giovanni, primary, Mori, Federica, primary, Leuzzi, Adriano, primary, Di Matteo, Elena, primary, Troise, Fulvia, primary, Abbate, Adele, primary, Merone, Rossella, primary, Ruzza, Valentino, primary, Diodoro, Maria Grazia, primary, Yadav, Mahesh, primary, Gordon-Alonso, Monica, primary, Vanhaver, Cristophe, primary, Panigada, Maddalena, primary, Soprana, Elisa, primary, Siccardi, Antonio, primary, Folgori, Antonella, primary, Colloca, Stefano, primary, van der Bruggen, Pierre, primary, Nicosia, Alfredo, primary, Lahm, Armin, primary, Catanese, Maria Teresa, primary, and Scarselli, Elisa, primary

Published
2023
Full Text
View/download PDF

5. 706 NOUS-PEV, a novel personalized viral-based prime/boost cancer immunotherapy targeting patient-specific neoantigens: interim results from the first subjects in the phase 1b study

Author

Bechter, Oliver, primary, Martin-Liberal, Juan, additional, D’Alise, Anna, additional, Leoni, Guido, additional, Cotugno, Gabriella, additional, Siani, Loredana, additional, Vitale, Rosa, additional, Ruzza, Valentino, additional, Micarelli, Elisa, additional, Garzia, Irene, additional, Faivre, Thea, additional, Gogov, Sven, additional, Delaite, Patricia, additional, Colloca, Stefano, additional, Ambrosio, Maria, additional, Merone, Rossella, additional, Scarselli, Elisa, additional, and Symeonides, Stefan, additional

Published
2022
Full Text
View/download PDF

6. Correction: A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C

Author

Napolitano, Federico, primary, Merone, Rossella, additional, Abbate, Adele, additional, Ammendola, Virginia, additional, Horncastle, Emma, additional, Lanzaro, Francesca, additional, Esposito, Marialuisa, additional, Contino, Alessandra Maria, additional, Sbrocchi, Roberta, additional, Sommella, Andrea, additional, Duncan, Joshua D., additional, Hinds, Joseph, additional, Urbanowicz, Richard A., additional, Lahm, Armin, additional, Colloca, Stefano, additional, Folgori, Antonella, additional, Ball, Jonathan K., additional, Nicosia, Alfredo, additional, Wizel, Benjamin, additional, Capone, Stefania, additional, and Vitelli, Alessandra, additional

Published
2021
Full Text
View/download PDF

7. A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability

Author

Leoni, Guido, primary, D'Alise, Anna Morena, additional, Cotugno, Gabriella, additional, Langone, Francesca, additional, Garzia, Irene, additional, De Lucia, Maria, additional, Fichera, Imma, additional, Vitale, Rosa, additional, Bignone, Veronica, additional, Tucci, Fabio Giovanni, additional, Mori, Federica, additional, Leuzzi, Adriano, additional, Di Matteo, Elena, additional, Troise, Fulvia, additional, Abbate, Adele, additional, Merone, Rossella, additional, Ruzza, Valentino, additional, Diodoro, Maria Grazia, additional, Yadav, Mahesh, additional, Gordon-Alonso, Monica, additional, Vanhaver, Cristophe, additional, Panigada, Maddalena, additional, Soprana, Elisa, additional, Siccardi, Antonio, additional, Folgori, Antonella, additional, Colloca, Stefano, additional, van der Bruggen, Pierre, additional, Nicosia, Alfredo, additional, Lahm, Armin, additional, Catanese, Maria Teresa, additional, and Scarselli, Elisa, additional

Published
2020
Full Text
View/download PDF

8. A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C

Author

Napolitano, Federico, primary, Merone, Rossella, additional, Abbate, Adele, additional, Ammendola, Virginia, additional, Horncastle, Emma, additional, Lanzaro, Francesca, additional, Esposito, Marialuisa, additional, Contino, Alessandra Maria, additional, Sbrocchi, Roberta, additional, Sommella, Andrea, additional, Duncan, Joshua D., additional, Hinds, Jospeh, additional, Urbanowicz, Richard A., additional, Lahm, Armin, additional, Colloca, Stefano, additional, Folgori, Antonella, additional, Ball, Jonathan K., additional, Nicosia, Alfredo, additional, Wizel, Benjamin, additional, Capone, Stefania, additional, and Vitelli, Alessandra, additional

Published
2020
Full Text
View/download PDF

9. A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability.

Author

UCL - SSS/DDUV/GECE - Génétique cellulaire, Leoni, Guido, D'Alise, Anna Morena, Cotugno, Gabriella, Langone, Francesca, Garzia, Irene, De Lucia, Maria, Fichera, Imma, Vitale, Rosa, Bignone, Veronica, Tucci, Fabio Giovanni, Mori, Federica, Leuzzi, Adriano, Di Matteo, Elena, Troise, Fulvia, Abbate, Adele, Merone, Rossella, Ruzza, Valentino, Diodoro, Maria Grazia, Yadav, Mahesh, Gordon-Alonso, Monica, Vanhaver, Christophe, Panigada, Maddalena, Soprana, Elisa, Siccardi, Antonio, Folgori, Antonella, Colloca, Stefano, Van Der Bruggen, Pierre, Nicosia, Alfredo, Lahm, Armin, Catanese, Maria Teresa, Scarselli, Elisa, UCL - SSS/DDUV/GECE - Génétique cellulaire, Leoni, Guido, D'Alise, Anna Morena, Cotugno, Gabriella, Langone, Francesca, Garzia, Irene, De Lucia, Maria, Fichera, Imma, Vitale, Rosa, Bignone, Veronica, Tucci, Fabio Giovanni, Mori, Federica, Leuzzi, Adriano, Di Matteo, Elena, Troise, Fulvia, Abbate, Adele, Merone, Rossella, Ruzza, Valentino, Diodoro, Maria Grazia, Yadav, Mahesh, Gordon-Alonso, Monica, Vanhaver, Christophe, Panigada, Maddalena, Soprana, Elisa, Siccardi, Antonio, Folgori, Antonella, Colloca, Stefano, Van Der Bruggen, Pierre, Nicosia, Alfredo, Lahm, Armin, Catanese, Maria Teresa, and Scarselli, Elisa

Abstract

Tumors with microsatellite instability (MSI) are caused by a defective DNA mismatch repair system that leads to the accumulation of mutations within microsatellite regions. Indels in microsatellites of coding genes can result in the synthesis of frameshift peptides (FSP). FSPs are tumor-specific neoantigens shared across patients with MSI. In this study, we developed a neoantigen-based vaccine for the treatment of MSI tumors. Genetic sequences from 320 MSI tumor biopsies and matched healthy tissues in The Cancer Genome Atlas database were analyzed to select shared FSPs. Two hundred nine FSPs were selected and cloned into nonhuman Great Ape Adenoviral and Modified Vaccinia Ankara vectors to generate a viral-vectored vaccine, referred to as Nous-209. Sequencing tumor biopsies of 20 independent patients with MSI colorectal cancer revealed that a median number of 31 FSPs out of the 209 encoded by the vaccine was detected both in DNA and mRNA extracted from each tumor biopsy. A relevant number of peptides encoded by the vaccine were predicted to bind patient HLA haplotypes. Vaccine immunogenicity was demonstrated in mice with potent and broad induction of FSP-specific CD8 and CD4 T-cell responses. Moreover, a vaccine-encoded FSP was processed by human antigen-presenting cells and was subsequently able to activate human CD8 T cells. Nous-209 is an "off-the-shelf" cancer vaccine encoding many neoantigens shared across sporadic and hereditary MSI tumors. These results indicate that Nous-209 can induce the optimal breadth of immune responses that might achieve clinical benefit to treat and prevent MSI tumors. SIGNIFICANCE: These findings demonstrate the feasibility of an "off-the-shelf" vaccine for treatment and prevention of tumors harboring frameshift mutations and neoantigenic peptides as a result of microsatellite instability.

Published
2020

10. Relationship between severe obesity and gut inflammation in children: what's next?

Author

Assante Luca, Squeglia Veronica, Franzese Adriana, Caiazzo Maria, Cicalese Maria, Spagnuolo Maria, Valerio Giuliana, Merone Rossella, and Guarino Alfredo

Subjects
Pediatrics, RJ1-570
Abstract

Abstract Background Preliminary evidence suggests an association between obesity and gut inflammation. Aims To evaluate the frequency of glucose abnormalities and their correlation with systemic and intestinal inflammation in severely obese children. Patients and Methods Thirty-four children (25 males; median age 10.8 ± 3.4 yrs) with severe obesity (BMI >95%) were screened for diabetes with oral glucose tolerance test (OGTT), systemic inflammation with C-reactive protein (CRP) and gut inflammation with rectal nitric oxide (NO) and faecal calprotectin. Results BMI ranged from 23 to 44 kg/m2, and BMI z-score between 2.08 e 4.93 (median 2.69 ± 0.53). Glucose abnormalities were documented in 71% of patients: type 2 diabetes in 29%, impaired fasting glucose (IFG) in 58%, and impaired glucose tolerance (IGT) in 37.5%. Thirty-one patients (91%) were hyperinsulinemic. CRP was increased in 73.5% with a correlation between BMI z-score and CRP (p 0.03). Faecal calprotectin was increased in 47% patients (mean 77 ± 68), and in 50% of children with abnormal glucose metabolism (mean 76 ± 68 μg/g), with a correlation with increasing BMI z-score. NO was pathological in 88%, and in 87.5% of glucose impairment (mean 6.8 ± 5 μM). Conclusions In this study, the prevalence of glucose abnormalities in obese children is higher than in other series; furthermore, a correlation is present between markers of systemic and intestinal inflammation and glucose abnormalities.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results