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Lake Nyos, a deep crater lake, located in the north-west of Cameroon, was permanently stratified below 50 m depth due to subaquatic sources supplying warm, salty and CO2-enriched water into the deepest reaches. The high CO2 content in these source waters caused the 1986 limnic eruption. The deep inflowing water is denser than the hypolimnetic water and maintains the stability of the water column, which is double-diffusively stratified. During the dry season in Feb 2002, cooling triggered the formation of a double-diffusive (DD) staircase, a sequence of homogeneously mixed layers separated by distinct stable interfaces. The initiation of the staircase was slightly below the permanent chemocline at ~ 50 m depth, from where the staircase expanded vertically in a diffusion-type manner for ~ 750 days to a maximal vertical extension of ~ 37 m. The staircase pattern caused the upward heat fluxes to increase which depleted the driving temperature gradient. Subsequently, the density ratio increased and reduced the upward heat flux divergence until DD progressively weakened and finally the staircase structure eroded. Based on 39 CTD profiles, we describe the DD phenomenon, explain the three distinct phases of this unique DD event, which lasted for ~ 850 days, and discuss the vertical extension of the DD zone in relation to the rates of new layer formation and layer decay. To our knowledge, this is the only observation over the entire lifespan—"from birth to death"—of a DD event in a natural water body. Article highlights: Early 2000s, Lake Nyos was double-diffusively stratified and developed a staircase of up to 27 layer-interface pairs Double-diffusive layering went through three phases (build-up, steadiness, and decay) and was active for ~ 850 days Upward heat flux divergence drove formation of new layers, which was in balance with layers decay for more than one year. [ABSTRACT FROM AUTHOR]