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4. Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Author

Pinho Guedes, Mariana Nunes, Maccarrone, Gaia, Pezzani, Maria Diletta, Sibani, Marcella, Davies, Ruth Joanna, Vitali, Stefania, Franchina, Giorgia, Tomassini, Giorgia, Sciammarella, Concetta, Cecchetto, Riccardo, Gibellini, Davide, De Toffoli, Chiara Konishi, Rosini, Giulia, Perlini, Chiara, Meroi, Marco, Cioli Puviani, Filippo, Fasan, Daniele, Micheletto, Claudio, Montemezzi, Stefania, Cardobi, Nicolò, Vantini, Gianluca, Mazzali, Gloria, Stabile, Giovanni, Marcanti, Maddalena, Zonta, Marco Pattaro, Calì, Deborah, Mason, Anna, Perlini, Cinzia, Gisondi, Paolo, Mongardi, Maria, Sorbello, Simona, Wold, Karin I., Vincenti-González, María F., Veloo, Alida C.M., Harmsma, Valerie P.R., Pantano, Daniele, van der Meer, Margriet, Gard, Lilli, Lizarazo, Erley F., Knoester, Marjolein, Friedrich, Alex W., Niesters, Hubert G.M., Viale, Pierluigi, Marzolla, Domenico, Cosentino, Federica, Di Chiara, Michela, Fornaro, Giacomo, Bonazzetti, Cecilia, Tazza, Beatrice, Toschi, Alice, Vetamanu, Oana, Giacomini, Maria Eugenia, Trapani, Fabio, Marconi, Lorenzo, Attard, Luciano, Tedeschi, Sara, Gabrielli, Liliana, Lazzarotto, Tiziana, Olivares, Paula, Castilla, Javier, Vélez, Javier, Almadana, Virginia, Martín-Barrera, Lucía, Martín-Gutiérrez, Ana Belén, Gutiérrez-Campos, David, Fernández-Regaña, Marta, Silva-Campos, Ana, Fernández-Riejos, Patricia, García-Sánchez, M. Isabel, Giuliano, Carla V., López, Carlota, Neumann, Gabriela, Camporro, Julieta, de Vedia, Lautaro, Agugliaro, Hugo, Scipione, Gabriella, Dellacasa, Chiara, Chandramouli, Balasubramanian, Gioiosa, Silvia, Naranjo, Juan Mata, Ortali, Maurizio, Konnova, Angelina, Gupta, Akshita, Smet, Mathias, Hotterbeekx, An, Berkell, Matilda, Sicuri, Elisa, Bachelet, Delphine, Bouadma, Lila, Cervantes-Gonzalez, Minerva, Chair, Anissa, Charpentier, Charlotte, Chenard, Léo, Descamps, Diane, Doan, Hang, Duval, Xavier, Esposito-Farese, Marina, Hoffmann, Isabelle, Kafif, Ouifiya, Le Hingrat, Quentin, Letrou, Sophie, Mentré, France, Schneider, Marion, Tardivon, Coralie, Timsit, Jean-Francois, Tubiana, Sarah, Abrous, Amal, Couffin-Cadiergues, Sandrine, Da Silva, Fernanda Dias, Esperou, Hélène, Houas, Ikram, Jaafoura, Salma, Papadopoulos, Aurélie, Ansart, Severine, Auvet, Adrien, Bani-Sadr, Firouzé, Bernard, L., Bissuel, François, Botelho-Nevers, Elisabeth, Bouhour, Damien, Cabié, André, Caraux Paz, Pauline, Chidiac, Christian, Chirouze, Catherine, Chroboczek, Tomasz, Cordel, Hugues, Courtois, Roxane, De Castro, Nathalie, Diamamntis, Sylvain, Diehl, Jean-Luc, Djossou, Felix, Dorival, Céline, Epaulard, Olivier, Gaborieau, Valerie, Goehringer, François, Gousseff, Marie, Jamard, Simon, Joseph, Cedric, Lacombe, Karine, Le Mestre, Soizic, Le Moing, Vincent, Lelievre, Jean-Daniel, Lesens, Olivier, Machado, M., Maillet, Mylène, Manda, Victoria, Martin-Blondel, Guillaume, Martinot, Martin, Meysonnier, Vanina, Molina, Jean-Michel, Oziol, Eric, Pestre, Vincent, Piroth, Lionel, Poissy, Julien, Rabaud, Christian, Raffi, François, Rammaert, Blandine, Rapp, Christophe, Rebaudet, Stanislas, Roger, Pierre-Marie, Roux, Damien, Senneville, Eric, Tattevin, Pierre, Wiedemann, Aurélie, Zucman, David, Gentilotti, Elisa, Górska, Anna, Tami, Adriana, Gusinow, Roy, Mirandola, Massimo, Rodríguez Baño, Jesús, Palacios Baena, Zaira R., Rossi, Elisa, Hasenauer, Jan, Lopes-Rafegas, Iris, Righi, Elda, Caroccia, Natascia, Cataudella, Salvatore, Pasquini, Zeno, Osmo, Thomas, Del Piccolo, Lidia, Savoldi, Alessia, Kumar-Singh, Samir, Mazzaferri, Fulvia, Caponcello, Maria Giulia, de Boer, Gerolf, Hara, Gabriel Levy, De Nardo, Pasquale, Malhotra, Surbhi, Canziani, Lorenzo Maria, Ghosn, Jade, Florence, Aline-Marie, Lafhej, Nadhem, van der Gun, Bernardina T.F., Giannella, Maddalena, Laouénan, Cédric, and Tacconelli, Evelina

Published
2023
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5. Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts

Author

Bassetti, Matteo, Vena, Antonio, Meroi, Marco, Cardozo, Celia, Cuervo, Guillermo, Giacobbe, Daniele Roberto, Salavert, Miguel, Merino, Paloma, Gioia, Francesca, Fernández-Ruiz, Mario, López-Cortés, Luis Eduardo, Almirante, Benito, Escolà-Vergé, Laura, Montejo, Miguel, Aguilar-Guisado, Manuela, Puerta-Alcalde, Pedro, Tasias, Mariona, Ruiz-Gaitán, Alba, González, Fernando, Puig-Asensio, Mireia, Marco, Francesc, Pemán, Javier, Fortún, Jesus, Aguado, Jose Maria, Soriano, Alejandro, Carratalá, Jordi, Garcia-Vidal, Carolina, Valerio, Maricela, Sartor, Assunta, Bouza, Emilio, and Muñoz, Patricia

Published
2020
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6. Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Author

Gentilotti, Elisa, primary, Górska, Anna, additional, Tami, Adriana, additional, Gusinow, Roy, additional, Mirandola, Massimo, additional, Rodríguez Baño, Jesús, additional, Palacios Baena, Zaira R., additional, Rossi, Elisa, additional, Hasenauer, Jan, additional, Lopes-Rafegas, Iris, additional, Righi, Elda, additional, Caroccia, Natascia, additional, Cataudella, Salvatore, additional, Pasquini, Zeno, additional, Osmo, Thomas, additional, Del Piccolo, Lidia, additional, Savoldi, Alessia, additional, Kumar-Singh, Samir, additional, Mazzaferri, Fulvia, additional, Caponcello, Maria Giulia, additional, de Boer, Gerolf, additional, Hara, Gabriel Levy, additional, De Nardo, Pasquale, additional, Malhotra, Surbhi, additional, Canziani, Lorenzo Maria, additional, Ghosn, Jade, additional, Florence, Aline-Marie, additional, Lafhej, Nadhem, additional, van der Gun, Bernardina T.F., additional, Giannella, Maddalena, additional, Laouénan, Cédric, additional, Tacconelli, Evelina, additional, Pinho Guedes, Mariana Nunes, additional, Maccarrone, Gaia, additional, Pezzani, Maria Diletta, additional, Sibani, Marcella, additional, Davies, Ruth Joanna, additional, Vitali, Stefania, additional, Franchina, Giorgia, additional, Tomassini, Giorgia, additional, Sciammarella, Concetta, additional, Cecchetto, Riccardo, additional, Gibellini, Davide, additional, De Toffoli, Chiara Konishi, additional, Rosini, Giulia, additional, Perlini, Chiara, additional, Meroi, Marco, additional, Puviani, Filippo Cioli, additional, Fasan, Daniele, additional, Micheletto, Claudio, additional, Montemezzi, Stefania, additional, Cardobi, Nicolò, additional, Vantini, Gianluca, additional, Mazzali, Gloria, additional, Stabile, Giovanni, additional, Marcanti, Maddalena, additional, Zonta, Marco Pattaro, additional, Calì, Deborah, additional, Mason, Anna, additional, Perlini, Cinzia, additional, Gisondi, Paolo, additional, Mongardi, Maria, additional, Sorbello, Simona, additional, Wold, Karin I., additional, Vincenti-González, María F., additional, Veloo, Alida C.M., additional, Harmsma, Valerie P.R., additional, Pantano, Daniele, additional, van der Meer, Margriet, additional, Gard, Lilli, additional, Lizarazo, Erley F., additional, Knoester, Marjolein, additional, Friedrich, Alex W., additional, Niesters, Hubert G.M., additional, Viale, Pierluigi, additional, Marzolla, Domenico, additional, Cosentino, Federica, additional, Di Chiara, Michela, additional, Fornaro, Giacomo, additional, Bonazzetti, Cecilia, additional, Tazza, Beatrice, additional, Toschi, Alice, additional, Vetamanu, Oana, additional, Giacomini, Maria Eugenia, additional, Trapani, Fabio, additional, Marconi, Lorenzo, additional, Attard, Luciano, additional, Tedeschi, Sara, additional, Gabrielli, Liliana, additional, Lazzarotto, Tiziana, additional, Olivares, Paula, additional, Castilla, Javier, additional, Vélez, Javier, additional, Almadana, Virginia, additional, Martín-Barrera, Lucía, additional, Martín-Gutiérrez, Ana Belén, additional, Gutiérrez-Campos, David, additional, Fernández-Regaña, Marta, additional, Silva-Campos, Ana, additional, Fernández-Riejos, Patricia, additional, García-Sánchez, M. Isabel, additional, Giuliano, Carla V., additional, López, Carlota, additional, Neumann, Gabriela, additional, Camporro, Julieta, additional, de Vedia, Lautaro, additional, Agugliaro, Hugo, additional, Scipione, Gabriella, additional, Dellacasa, Chiara, additional, Chandramouli, Balasubramanian, additional, Gioiosa, Silvia, additional, Naranjo, Juan Mata, additional, Ortali, Maurizio, additional, Konnova, Angelina, additional, Gupta, Akshita, additional, Smet, Mathias, additional, Hotterbeekx, An, additional, Berkell, Matilda, additional, Sicuri, Elisa, additional, Bachelet, Delphine, additional, Bouadma, Lila, additional, Cervantes-Gonzalez, Minerva, additional, Chair, Anissa, additional, Charpentier, Charlotte, additional, Chenard, Léo, additional, Descamps, Diane, additional, Doan, Hang, additional, Duval, Xavier, additional, Esposito-Farese, Marina, additional, Hoffmann, Isabelle, additional, Kafif, Ouifiya, additional, Le Hingrat, Quentin, additional, Letrou, Sophie, additional, Mentré, France, additional, Schneider, Marion, additional, Tardivon, Coralie, additional, Timsit, Jean-Francois, additional, Tubiana, Sarah, additional, Abrous, Amal, additional, Couffin-Cadiergues, Sandrine, additional, Da Silva, Fernanda Dias, additional, Esperou, Hélène, additional, Houas, Ikram, additional, Jaafoura, Salma, additional, Papadopoulos, Aurélie, additional, Ansart, Severine, additional, Auvet, Adrien, additional, Bani-Sadr, Firouzé, additional, Bernard, L., additional, Bissuel, François, additional, Botelho-Nevers, Elisabeth, additional, Bouhour, Damien, additional, Cabié, André, additional, Caraux Paz, Pauline, additional, Chidiac, Christian, additional, Chirouze, Catherine, additional, Chroboczek, Tomasz, additional, Cordel, Hugues, additional, Courtois, Roxane, additional, De Castro, Nathalie, additional, Diamamntis, Sylvain, additional, Diehl, Jean-Luc, additional, Djossou, Felix, additional, Dorival, Céline, additional, Epaulard, Olivier, additional, Gaborieau, Valerie, additional, Goehringer, François, additional, Gousseff, Marie, additional, Jamard, Simon, additional, Joseph, Cedric, additional, Lacombe, Karine, additional, Le Mestre, Soizic, additional, Le Moing, Vincent, additional, Lelievre, Jean-Daniel, additional, Lesens, Olivier, additional, Machado, M., additional, Maillet, Mylène, additional, Manda, Victoria, additional, Martin-Blondel, Guillaume, additional, Martinot, Martin, additional, Meysonnier, Vanina, additional, Molina, Jean-Michel, additional, Oziol, Eric, additional, Pestre, Vincent, additional, Piroth, Lionel, additional, Poissy, Julien, additional, Rabaud, Christian, additional, Raffi, François, additional, Rammaert, Blandine, additional, Rapp, Christophe, additional, Rebaudet, Stanislas, additional, Roger, Pierre-Marie, additional, Roux, Damien, additional, Senneville, Eric, additional, Tattevin, Pierre, additional, Wiedemann, Aurélie, additional, and Zucman, David, additional

Published
2023
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8. Additional file 1 of Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts

Author

Bassetti, Matteo, Vena, Antonio, Meroi, Marco, Cardozo, Celia, Cuervo, Guillermo, Giacobbe, Daniele Roberto, Salavert, Miguel, Merino, Paloma, Gioia, Francesca, Fernández-Ruiz, Mario, López-Cortés, Luis Eduardo, Almirante, Benito, Escolà-Vergé, Laura, Montejo, Miguel, Aguilar-Guisado, Manuela, Puerta-Alcalde, Pedro, Mariona Tasias, Ruiz-Gaitán, Alba, González, Fernando, Puig-Asensio, Mireia, Marco, Francesc, Pemán, Javier, Fortún, Jesus, Aguado, Jose Maria, Soriano, Alejandro, Carratalá, Jordi, Garcia-Vidal, Carolina, Valerio, Maricela, Sartor, Assunta, Bouza, Emilio, and Muñoz, Patricia

Subjects
fluids and secretions, hemic and lymphatic diseases, biochemical phenomena, metabolism, and nutrition, equipment and supplies, bacterial infections and mycoses
Abstract

Additional file 1. Comparison between patients with and without intra-abdominal origin of candidemia.

Published
2020
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9. Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts

Author

Ministerio de Sanidad y Consumo (España), Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Bassetti, Matteo, Vena, Antonio, Meroi, Marco, Cardozo, Celia, Cuervo, Guillermo, Giacobbe, Daniele Roberto, Salavert, Miguel, Merino, Paloma, Gioia, Francesca, Fernández-Ruiz, Mario, López-Cortés, Luis Eduardo, Almirante, Benito, Escolà‐Vergé, Laura, Montejo, Miguel, Aguilar Guisado, Manuela, Puerta-Alcalde, Pedro, Tasias Pitarch, M., Ruiz-Gaitán, Alba, González, Fernando, Puig-Asensio, M., Marco, Francesc, Pemán, Javier, Fortún, Jesús, Aguado, José María, Soriano, Álex, Carratalà, Jordi, García‐Vidal, Carolina, Valerio, Maricela, Sartor, Assunta, Bouza Santiago, Emilio, Muñoz, Patricia, Ministerio de Sanidad y Consumo (España), Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Bassetti, Matteo, Vena, Antonio, Meroi, Marco, Cardozo, Celia, Cuervo, Guillermo, Giacobbe, Daniele Roberto, Salavert, Miguel, Merino, Paloma, Gioia, Francesca, Fernández-Ruiz, Mario, López-Cortés, Luis Eduardo, Almirante, Benito, Escolà‐Vergé, Laura, Montejo, Miguel, Aguilar Guisado, Manuela, Puerta-Alcalde, Pedro, Tasias Pitarch, M., Ruiz-Gaitán, Alba, González, Fernando, Puig-Asensio, M., Marco, Francesc, Pemán, Javier, Fortún, Jesús, Aguado, José María, Soriano, Álex, Carratalà, Jordi, García‐Vidal, Carolina, Valerio, Maricela, Sartor, Assunta, Bouza Santiago, Emilio, and Muñoz, Patricia

Abstract

[Background] Almost one third of the patients with candidemia develop septic shock. The understanding why some patients do and others do not develop septic shock is very limited. The objective of this study was to identify variables associated with septic shock development in a large population of patients with candidemia., [Methods] A post hoc analysis was performed on two prospective, multicenter cohort of patients with candidemia from 12 hospitals in Spain and Italy. All episodes occurring from September 2016 to February 2018 were analyzed to assess variables associated with septic shock development defined according to The Third International Consensus Definition for Sepsis and Septic Shock (Sepsis-3)., [Results] Of 317 candidemic patients, 99 (31.2%) presented septic shock attributable to candidemia. Multivariate logistic regression analysis identifies the following factors associated with septic shock development: age > 50 years (OR 2.57, 95% CI 1.03–6.41, p = 0.04), abdominal source of the infection (OR 2.18, 95% CI 1.04–4.55, p = 0.04), and admission to a general ward at the time of candidemia onset (OR 0.21, 95% CI, 0.12–0.44, p = 0.001). Septic shock development was independently associated with a greater risk of 30-day mortality (OR 2.14, 95% CI 1.08–4.24, p = 0.02)., [Conclusions] Age and abdominal source of the infection are the most important factors significantly associated with the development of septic shock in patients with candidemia. Our findings suggest that host factors and source of the infection may be more important for development of septic shock than intrinsic virulence factors of organisms.

Published
2020

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