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2. Short-Term Tolerability of Morniflumate in Patients with Cutaneous Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs

Author

Antonio Ferrannini, Angelo Vacca, Eustachio Nettis, Mero F, Di Leo E, and A.M. Aloia

Subjects
Pharmacology, Drug, business.industry, media_common.quotation_subject, Immunology, Niflumic acid, Nicotinic agonist, Tolerability, Non steroidal anti inflammatory, Cutaneous hypersensitivity, Immunology and Allergy, Medicine, In patient, business, Morniflumate, medicine.drug, media_common
Abstract

Morniflumate is the morpholinoethyl ester of niflumic acid, a non-steroidal antiinflammatory drug, derived from nicotinic acid. We studied 112 patients who had experienced cutaneous reactions after using non-steroidal anti-inflammatory drugs. Only two of all the patients who underwent an oral challenge with morniflumate had a positive result to the test. By demonstrating the low incidence of reactions to morniflumate through oral challenges, we suggest that patients with non-steroidal anti-inflammatory drug hypersensitivity may tolerate this drug which would therefore be a useful alternative.

Published
2013
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3. Effects of Water Quality, Stocking Density, Water Exchange Frequency, and Food, on Growth and Survival of the Green Mussel, Perna viridis Larvae.

Author

Apines-Amar, M. J., Rendaje, D. C., Piñosa, L. A. G., Laureta Jr., L. V., Masculino, A. N. D., Pedroso, F. L., Mero, F. F. C., Capaque, T. P. V., and Cadangin, J. F.

Subjects
PERNA, WATER quality, NATURAL foods, MOLLUSKS, BROOD stock assessment
Abstract

Experiments were conducted to determine the optimum conditions for growth and survival of the green mussel, Perna viridis larvae. Effects of various temperatures and salinities, stocking densities, water exchange frequency, and natural food preference of the larvae from D-hinged to pediveliger stage were investigated. The green mussel broodstocks were collected from the natural source, and spawning occurred in captivity. All experiments were conducted in triplicate. The results demonstrated that larvae from D-hinged to pediveliger stage had better growth and survival when the temperature was between 29°C and 30°C, and salinity ranging from 30-33ppt. Stocking density from 10- 20 larvae/ml did not affect growth and survival of the larvae. Likewise, frequency of water replacement from daily to every 5 day interval did not influence the growth and survival until the pediveliger stage. During this stage, the larvae preferred a combination of Isochrysis galbana and Chaetoceros calcitrans as food in terms of better growth, and either Isochrysis galbana, Chaetoceros calcitrans, or their combination in terms of higher survival rate. [ABSTRACT FROM AUTHOR]

Published
2020

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