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Background: Infantile hemangiomas (IH) are the most common vascular tumors of infancy. Nearly 4–10% of infants require systemic treatment due to uncontrolled endothelial cell proliferation. Oral propranolol has been approved for the treatment of IH. Herein, we present our experience about the safety and tolerance of this treatment. Materials and Methods: This was a fourteen-year, prospective study conducted between 2008 and 2022 by the dermatology and pediatrics departments of the Hassan II University Hospital Center, located in Fez, Morocco, involving 215 children with infantile hemangioma with an indication for treatment by oral propranolol. Results: After a median follow-up period of fourteen years, the mean age of onset was six months. We encountered a 19% rate of side effects. Therapy was interrupted due to the occurrence of bronchospasm in two cases. Four patients (2.5%) had episodes of bronchiolitis. Other side effects were digestive disorders in 3%, sleep disorders in 6 cases, and coldness of the extremities in 7 cases. Four patients (8.6%) had a volumetric rebound. However, we noted sequelae, such as residual telangiectasias (39% cases), anetodermal skin in 15%, and unsightly scars in 24%. Conclusion: Our data shows that propranolol was generally well tolerated by young infants. We found side effects to be mostly minor, transient, and manageable, except for two cases of bronchospasm, whose treatment was permanently discontinued. This may be explained by the late age of treatment onset, yet we noted sequelae, such as telangiectasias and anetodermal skin. [ABSTRACT FROM AUTHOR]

Background: Vulvar lichen sclerosus (VLS) is an uncommon inflammatory dermatosis affecting the anogenital region. There are two peaks of incidence: one in prepubertal girls and the other in postmenopausal women. Its etiopathogenesis remains unknown. Objective: The objective was to specify the clinical characteristics of VLS in the female pediatric population in order to plan early treatment. Results: A total of 12 pediatric female patients were identified in the study. The mean age of onset was six years. Numerous potential etiological factors for VLS development were identified. Pruritus was the main symptom in a significant proportion of the patients. All patients had a good response to topical therapy with no significant side effects. Conclusion: VLS should be suspected in the presence of chronic vulvar pruritus in order to avoid tragic repercussions in adulthood. Appropriate treatment for each patient is essential as is the prevention of the side effects of applied treatments. [ABSTRACT FROM AUTHOR]

Background: Due to the lack of a large series of benign and malignant vulvar lesions, the features of dermoscopy are not well established. Objective: The aim of our study was to describe the epidemiological profile and the clinical and dermoscopic characteristics that may indicate malignancy or benignity in vulvar hyperpigmentation. Materials and Methods: From June 2020 to June 2023, we conducted a retrospective, prospective study involving 42 patients with 59 pigmented lesions. Results: The parallel, homogeneous, and globular patterns were observed in benign lesions (nevi, lentigo, melanosis). The cerebriform pattern was observed in seborrheic keratosis and Bowen's disease (BD). In cases of BD, we also observed white, structureless areas, glomerular vessels, a homogeneous brownishgray area, and brown dots. Conclusion: Good clinico-dermoscopic correlation should guide the diagnosis and management of pigmented vulvar lesions. Dermoscopy may be helpful in distinguishing between a benign lesion and a malignant lesion, yet in cases of doubt, a biopsy may be necessary. [ABSTRACT FROM AUTHOR]

Background: DRESS syndrome (drug reaction with eosinophilia and systemic symptoms syndrome) is a severe druginduced skin reaction that may be life-threatening, particularly due to its visceral involvement. The liver is the primary organ responsible for the metabolism of most medications. Several reviews and articles have highlighted the liver as the most affected organ in DRESS syndrome, making it intriguing to study this aspect in more detail. Materials and Methods: This was a retrospective, descriptive, and analytical study conducted at the dermatology department in Fez, Morocco, from 2014 to 2023, including all cases presenting with DRESS syndrome diagnosed based on clinical, biological, histological, and chronological arguments, with a RegiSCAR score classified as probable or definite. Hepatic involvement was assessed based on the classification of drug-induced hepatitis using alkaline phosphatase (ALP) levels, alanine aminotransferase (ALT) levels, and the ALT/ALP ratio (R), thus defining three clinical forms: cytolytic (ALT > 2 or R > 5), cholestatic (ALP > 2 or R < 2), and mixed (2 < R < 5). Results: 72 patients were included, with 47.2% experiencing hepatic involvement, including 48.5% with cytolytic, 36.4% with cholestatic, and 15% with mixed forms. Among these, 55.9% had associated renal involvement, 29.9% presented with erythroderma, 55.9% with a maculopapular rash, 8.8% with a morbilliform rash, 5.9% with an erythema multiforme-like eruption, and 79.9% had eosinophilia. Allopurinol was the most implicated drug (50%), followed by neuroleptics (17.6%), Salazopyrin (14.7%), and antibiotics (8.8%). The association between Salazopyrin and hepatic involvement was significant (p < 0.05), while the statistical analysis of other parameters did not reveal such an association. Management involved local care, with 50% of the patients placed on corticosteroid therapy. 8.8% of the patients died, while the others showed normalized liver function tests in 74.19% of cases, with the rest lost to follow-up. Conclusion: Hepatic involvement is common in DRESS syndrome, predominantly manifesting as cytolytic or cholestatic patterns. Maculopapular rash and erythroderma are the most commonly observed cutaneous phenotypes. These patients are more likely to have associated renal involvement and eosinophilia. Allopurinol, neuroleptics, and Salazopyrin are the most frequently implicated drugs. [ABSTRACT FROM AUTHOR]

Mycetomas are pathological processes in which fungal or actinomycotic agents emit seeds. It is a chronic infectious disease, endemic in tropical countries, that affects the soft tissues and the skeleton with sometimes fatal visceral damage. Foot involvement is by far the most common, occurring in 80% of cases. The treatment of mycetomas depends on their etiology, medical or surgical. Herein, we report a rare case of a foot and leg eumycetoma. The purpose of this work was to recall this rare condition, often overlooked by practitioners, remaining a source of therapeutic difficulties. [ABSTRACT FROM AUTHOR]

Copyright of Cahiers Santé - Médecine Thérapeutique is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cahiers Santé - Médecine Thérapeutique is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cahiers Santé - Médecine Thérapeutique is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mycosis fungoides is the most common subtype of primary cutaneous T-cell lymphoma, its evolution is indolent, except in the case of transformation into large T-cell lymphoma. A 63-year-old patient, he has a stage IB mycosis fungoid for 4 years treated by topical corticosteroids associated with methotrexate. Then he had progressed to stage IIb, treated by PUVA (photochemotherapy) and acitretin with complete remission and then relapsed, with the appearance of tumors, and adenopathy, the extension assessment had objectified a transformed CD30 mycosis fungoid, with a lymph node localization of T lymphoma, the patient is classified as stage IIIB. Thoracic-abdomino-pelvic CT had shown a thickening of the sigmoid colon wall, completed by colonoscopy, whose colon biopsy had objectified a colonic adenocarcinoma. The association of colonic adenocarcinoma and a mycosis fongoide is rare, a pathophysiology is poorly understood, suggests a probably genetic predisposition.

Copyright of Cahiers Santé - Médecine Thérapeutique is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Discoid lupus erythematosus (DLE) and Sdermatomyositis (DM) are two connectivitises with frequent scalp involvement and similar clinical features. Objective: The objective of this study was to evaluate and compare the trichoscopic findings in patients with DM and DLE and to determine the distinctive feature of each pathology that may help in the differential diagnosis. Materials and Methods: We performed an analytical, comparative primary study of trichoscopic images belonging to 32 patients (18 cases of lupus and 14 of dermatomyositis) with a total of seventy lesions over a period of two years. Results: Eighteen cases of discoid lupus and fourteen cases of dermatomyositis were included. Trichoscopic founding revealed that abnormalities of follicular openings, pigment disorders, white structures, and downy hair were more frequent in lupus, and vascular patterns and dystrophic and circular hair were more prominent in dermatomyositis. The analytical study revealed that the absence or reduced number of follicular openings (p = 0.024), the presence of sliding sheaths (p = 0.048) were significant signs in favor of lupus; and the presence of perifollicular erythema (p = 0.0001), linear fine vessels and telangiectasia (p = 0.031), and pseudo-lake structures (p = 0.002) were associated with dermatomyositis. Conclusion: Trichoscopic examination is a valuable tool for the diagnosis of connectivitis. [ABSTRACT FROM AUTHOR]

Background: The most malignant skin tumors of the head are dominated by epithelial cancers, particularly basal cell carcinomas, followed by squamous cell carcinomas and melanomas. Herein, we present a case series of malignant skin cancers in the cephalic region. We address their epidemiological, clinical, histological, and therapeutic profiles in our context. Materials and Methods: This was a prospective study conducted for descriptive purposes on cases of skin cancer, including melanoma, squamous cell carcinoma, and basal cell carcinoma, followed at the dermatology department of CHU Hassan II Fez between June 2017 and December 2021. Results: We collected a total of 260 patients with different types of skin cancer. 147 cases (57%) were in the cephalic location: 56% presented squamous cell carcinoma, followed by melanoma (22%) and basal cell carcinoma (21%). Conclusion: The early detection of skin cancer is essential to reduce the functional morbidity and mortality associated with these tumors, especially in these cephalic locations. [ABSTRACT FROM AUTHOR]

Introduction: Pemphigoid gestationis (PG) is a rare autoimmune skin disorder that occurs during pregnancy. Materials and Methods: Prospective study including all cases of PG diagnosed between 2010 and 2015. Results: We reported 16 patients: 12 multiparous and 4 primiparous, the average age was 30.43 years. The onset of the disease was done in 43.75% of cases at 3 trimester, and 25% of the 2 trimester with three cases of early post partum and post abortum cases. All patients had urticarial papules, vesicule were found in 85.7%. The beginning was done in periumbilical 62.5%. Histology objectified in all cases a sub epidermal detachment, and the IFD performed in 8 cases, objectified in 6 patients a linear deposit of C3 along the dermoepidermal junction. All patients were treated with Bethametasone at 30 g/d with a progressive degression over several months. Concerning the fetal prognosis we found two cases of prematurity, and one case of fetal death. One patient had a choriocarcinoma complicated molar pregnancy. Conclusion: All our patients evolved well under topical corticosteroids of very strong class, even with extensive lesions, so suggesting their first-line use, avoiding the recourse to the oral corticotherapy.