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Author(s): Raymond C. Nairn [sup.1] , Thomas V. Merluzzi [sup.2] Author Affiliations: (Aff1) Novi, MI, USA (Aff2) 0000 0001 2168 0066, grid.131063.6, University of Notre Dame, , 46556, Notre Dame, [...], The purpose of this project was to develop a short-term, theory-based intervention for patients with self-reported limited self-efficacy to perform coping behaviors. Cancer patients with low coping self-efficacy were randomly assigned to a treatment (N = 66) or control condition (N = 68). The treatment, Mastery Enhancement Therapy, was based on self-regulation and self-efficacy theories. Measures of coping self-efficacy, functional status, depression, quality of life, and adjustment were administered at baseline, after session two, after the final (fourth) session, and at 3 months post-treatment. Control participants completed the measures at about the same time intervals. Treatment participants reported highly significant immediate post-treatment improvement in self-efficacy for coping compared to controls, although controls improved by 3 months post-treatment. However, treatment participants with lower levels of functional status benefited more than controls on depression and adjustment at follow-up. Mastery Enhancement Therapy is a time-limited treatment that increases coping efficacy and subsequently adjustment during active medical treatment, and appears to warrant a large-scale RCT with patients with below average coping self-efficacy and moderate to high symptoms.

Perceived discrimination (PD; e.g. racism, agism, sexism, etc.) negatively impacts quality of life (QOL) among cancer patients. Prior research has established that for African American Cancer Patients (AACPs) only disengagement/denial coping mediated the PD-QOL relationship. In contrast, for Caucasian American Cancer Patients (CACPs), both agentic and disengagement/denial coping were mediators of the PD-QOL relationship. However, according to social constraint theory there may be a difference between subtle and overt PD in terms of the utility of certain coping mechanisms in relation to QOL, especially for AACPs. 217 AACPs and 121 CACPs completed measures of PD, coping (agentic, disengagement/denial, adaptive disengagement) and QOL. PD items were classified as subtle or overt microaggressions. PD was mainly attributed to race/ethnicity by AACPs and to income, age, and physical appearance for CACPs. : In both subtle and overt microaggression models with CACPs, agentic coping and disengagement/denial coping were significant mediators of PD-QOL. Like CACPs, for AACPs, agentic and disengagement/denial coping were significant in the context of subtle microaggressions. In contrast, for overt microaggression only disengagement/denial coping was a significant mediator of the PD-QOL relationship for AACPs. Adaptive disengagement was related to QOL only for AACPs. : Whereas more research is needed, it appears that overt microaggressions for AACPs, that consist mainly of racial and ethnic maltreatment, constitute a class of social contexts that may raise above the threshold for serious threat and harm, and, as a result, disengagement/constraint may reduce negative consequences. This additional burden for AACPs contributes to disparities in QOL. Future research is needed on the utility of adaptive disengagement for AACPs in relation to PD. [ABSTRACT FROM AUTHOR]

Stress related to the COVID-19 pandemic has implications for mental and physical well-being, but especially for persons with cancer. The stress mitigating role of tolerance of uncertainty (TU) was investigated in those with and without a cancer diagnosis. Design: 155 persons with and 150 without a cancer diagnosis completed measures of pandemic stress and TU (mediating variable). Main Outcome Measures: Measures of emotional and physical well-being (WB) were the outcome variables. Results: The mediated, indirect effect of TU in the pandemic stress-emotional WB relationship was significant for the cancer group and the non-cancer group. However, the indirect effects involving TU in the pandemic stress-physical WB relationship was not significant for the cancer group, whereas TU fully mediated the pandemic stress-physical WB relationship for the non-cancer group. Conclusions: Whereas TU was active as a mediator with emotional WB for both groups, it was ineffective as a mediator of the pandemic stress-physical WB relationship with the cancer group. Thus, the cancer group's physical WB was determined exclusively by pandemic stress. Stress reduction and enhancing TU may be critical for all people but for those with cancer decreasing pandemic stress would provide the most viable option for increasing physical well-being. [ABSTRACT FROM AUTHOR]

Thirty spider-phobic adults underwent exposure to 17 phobic-related, graded performance tests. Fifteen subjects were assigned to naltrexone, an opioid antagonist, and 15 were assigned to placebo. Naltrexone had a significant effect on exposure, with naltrexone subjects taking significantly longer to complete first 10 steps of exposure and with significantly more of naltrexone subjects being unable to complete treatment. (Author/NB)

The Psychosocial Adjustment to Illness Scale (PAIS) is often used as a self-report measure, although its reliability and validity have not been widely tested on persons with cancer. A study was undertaken to confirm the seven conceptual scales of the PAIS-SR and investigate its validty, based on a large sample of patients with a variety of cancer diagnoses. The results support validity of the PAIS-SR and its use in cancer research.