Search

Your search keyword '"Merid, Simon Kebede"' showing total 213 results
Start Over Author "Merid, Simon Kebede"
213 results on '"Merid, Simon Kebede"'

1. Lung-function trajectories: relevance and implementation in clinical practice

Author

Abellan, Alicia, Adcock, Ian, Afzal, Shoaib, Alter, Peter, Backman, Helena, Bertels, Xander, Bloom, Chloe, Bønnelykke, Klaus, Breyer, Marie-Kathrin, Casas, Sandra, Chung, Fan (Kian), Colak, Yunus, Cosio, Borja G., Duijts, Liesbeth, Fabbri, Leonardo, Fontanella, Sara, Fuertes, Elaine, Gonzalez, Juan Ramón, Granell, Raquel, Hartl, Sylvia, Hernandez-Pacheco, Natalia, Holloway, John, Jarvis, Deborah, Koefoed, Hans Jacob, Kole, Tessa, Kumar, Ashish, Langhammer, Arnulf, Lindberg, Anne, Llopis, Maria, Maitland van der Zee, Anke-Hilse, Meteran, Howraman, Minelli, Cosetta, Nwaru, Bright, Olvera, Nuria, Peralta, Gabriela, Ritchie, Andrew, Rönmark, Eva, Ross Chapman, James, Sangüesa Boix, Júlia, Schikowski, Tamara, Schlünssen, Vivi, Shaheen, Seif, Sigsgaard, Torben, Standl, Marie, Talaei, Mohammad, Ullah, Anhar, Ullman, Anders, Valencia-Hernandez, Carlos, van den Berge, Maarten, van Dijk, Yoni, Vestbo, Jørgen, Vijverberg, Susanne, Vikjord, Sigrid Anna, Volgelmeier, Claus, Vonk, Judith, Zounemat Kermani, Nazanin, Melén, Erik, Faner, Rosa, Allinson, James P, Bui, Dinh, Bush, Andrew, Custovic, Adnan, Garcia-Aymerich, Judith, Guerra, Stefano, Breyer-Kohansal, Robab, Hallberg, Jenny, Lahousse, Lies, Martinez, Fernando D, Merid, Simon Kebede, Powell, Pippa, Pinnock, Hilary, Stanojevic, Sanja, Vanfleteren, Lowie E G W, Wang, Gang, Dharmage, Shyamali C, Wedzicha, Jadwiga, and Agusti, Alvar

Published
2024
Full Text
View/download PDF

2. Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Author

Kadalayil, Latha, Alam, Md. Zahangir, White, Cory Haley, Ghantous, Akram, Walton, Esther, Gruzieva, Olena, Merid, Simon Kebede, Kumar, Ashish, Roy, Ritu P., Solomon, Olivia, Huen, Karen, Eskenazi, Brenda, Rzehak, Peter, Grote, Veit, Langhendries, Jean-Paul, Verduci, Elvira, Ferre, Natalia, Gruszfeld, Darek, Gao, Lu, Guan, Weihua, Zeng, Xuehuo, Schisterman, Enrique F., Dou, John F., Bakulski, Kelly M., Feinberg, Jason I., Soomro, Munawar Hussain, Pesce, Giancarlo, Baiz, Nour, Isaevska, Elena, Plusquin, Michelle, Vafeiadi, Marina, Roumeliotaki, Theano, Langie, Sabine A. S., Standaert, Arnout, Allard, Catherine, Perron, Patrice, Bouchard, Luigi, van Meel, Evelien R., Felix, Janine F., Jaddoe, Vincent W. V., Yousefi, Paul D., Ramlau-Hansen, Cecilia H., Relton, Caroline L., Tobi, Elmar W., Starling, Anne P., Yang, Ivana V., Llambrich, Maria, Santorelli, Gillian, Lepeule, Johanna, Salas, Lucas A., Bustamante, Mariona, Ewart, Susan L., Zhang, Hongmei, Karmaus, Wilfried, Röder, Stefan, Zenclussen, Ana Claudia, Jin, Jianping, Nystad, Wenche, Page, Christian M., Magnus, Maria, Jima, Dereje D., Hoyo, Cathrine, Maguire, Rachel L., Kvist, Tuomas, Czamara, Darina, Räikkönen, Katri, Gong, Tong, Ullemar, Vilhelmina, Rifas-Shiman, Sheryl L., Oken, Emily, Almqvist, Catarina, Karlsson, Robert, Lahti, Jari, Murphy, Susan K., Håberg, Siri E., London, Stephanie, Herberth, Gunda, Arshad, Hasan, Sunyer, Jordi, Grazuleviciene, Regina, Dabelea, Dana, Steegers-Theunissen, Régine P. M., Nohr, Ellen A., Sørensen, Thorkild I. A., Duijts, Liesbeth, Hivert, Marie-France, Nelen, Vera, Popovic, Maja, Kogevinas, Manolis, Nawrot, Tim S., Herceg, Zdenko, Annesi-Maesano, Isabella, Fallin, M. Daniele, Yeung, Edwina, Breton, Carrie V., Koletzko, Berthold, Holland, Nina, Wiemels, Joseph L., Melén, Erik, Sharp, Gemma C., Silver, Matt J., Rezwan, Faisal I., and Holloway, John W.

Published
2023
Full Text
View/download PDF

3. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.

Author

Merid, Simon Kebede, Novoloaca, Alexei, Sharp, Gemma C, Küpers, Leanne K, Kho, Alvin T, Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne O, Kazmi, Nabila, Salas, Lucas A, Rezwan, Faisal I, Zhang, Hongmei, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl L, Melton, Phillip E, Lawlor, Debbie A, Pershagen, Göran, Breton, Carrie V, Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim S, Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen Aagaard, Bustamante, Mariona, Ewart, Susan L, Karmaus, Wilfried, Zhao, Shanshan, Page, Christian M, Herceg, Zdenko, Jarvelin, Marjo-Riitta, Lahti, Jari, Baccarelli, Andrea A, Anderson, Denise, Kachroo, Priyadarshini, Relton, Caroline L, Bergström, Anna, Eskenazi, Brenda, Soomro, Munawar Hussain, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent W, Sørensen, Thorkild IA, Vrijheid, Martine, Arshad, S Hasan, Holloway, John W, Håberg, Siri E, Magnus, Per, Dwyer, Terence, Binder, Elisabeth B, DeMeo, Dawn L, Vonk, Judith M, Newnham, John, Tantisira, Kelan G, Kull, Inger, Wiemels, Joseph L, Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica C, Räikkönen, Katri, Oken, Emily, Huang, Rae-Chi, Weiss, Scott T, Antó, Josep Maria, Bousquet, Jean, Kumar, Ashish, Söderhäll, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah E, Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Hivert, Marie-France, Felix, Janine F, Koppelman, Gerard H, London, Stephanie J, and Melén, Erik

Subjects
Humans, Premature Birth, DNA, DNA Methylation, Fetal Development, Adolescent, Child, Child, Preschool, Infant, Newborn, Infant, Premature, Female, Male, Genetic Loci, Epigenome, Development, Epigenetics, Gestational age, Preterm birth, Transcriptomics, Preschool, Infant, Newborn, Premature, Genetics, Clinical Sciences
Abstract

BackgroundPreterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children.MethodsWe performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung.ResultsWe identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P

Published
2020

5. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Author

Küpers, Leanne K, Monnereau, Claire, Sharp, Gemma C, Yousefi, Paul, Salas, Lucas A, Ghantous, Akram, Page, Christian M, Reese, Sarah E, Wilcox, Allen J, Czamara, Darina, Starling, Anne P, Novoloaca, Alexei, Lent, Samantha, Roy, Ritu, Hoyo, Cathrine, Breton, Carrie V, Allard, Catherine, Just, Allan C, Bakulski, Kelly M, Holloway, John W, Everson, Todd M, Xu, Cheng-Jian, Huang, Rae-Chi, van der Plaat, Diana A, Wielscher, Matthias, Merid, Simon Kebede, Ullemar, Vilhelmina, Rezwan, Faisal I, Lahti, Jari, van Dongen, Jenny, Langie, Sabine AS, Richardson, Tom G, Magnus, Maria C, Nohr, Ellen A, Xu, Zongli, Duijts, Liesbeth, Zhao, Shanshan, Zhang, Weiming, Plusquin, Michelle, DeMeo, Dawn L, Solomon, Olivia, Heimovaara, Joosje H, Jima, Dereje D, Gao, Lu, Bustamante, Mariona, Perron, Patrice, Wright, Robert O, Hertz-Picciotto, Irva, Zhang, Hongmei, Karagas, Margaret R, Gehring, Ulrike, Marsit, Carmen J, Beilin, Lawrence J, Vonk, Judith M, Jarvelin, Marjo-Riitta, Bergström, Anna, Örtqvist, Anne K, Ewart, Susan, Villa, Pia M, Moore, Sophie E, Willemsen, Gonneke, Standaert, Arnout RL, Håberg, Siri E, Sørensen, Thorkild IA, Taylor, Jack A, Räikkönen, Katri, Yang, Ivana V, Kechris, Katerina, Nawrot, Tim S, Silver, Matt J, Gong, Yun Yun, Richiardi, Lorenzo, Kogevinas, Manolis, Litonjua, Augusto A, Eskenazi, Brenda, Huen, Karen, Mbarek, Hamdi, Maguire, Rachel L, Dwyer, Terence, Vrijheid, Martine, Bouchard, Luigi, Baccarelli, Andrea A, Croen, Lisa A, Karmaus, Wilfried, Anderson, Denise, de Vries, Maaike, Sebert, Sylvain, Kere, Juha, Karlsson, Robert, Arshad, Syed Hasan, Hämäläinen, Esa, Routledge, Michael N, Boomsma, Dorret I, Feinberg, Andrew P, Newschaffer, Craig J, Govarts, Eva, Moisse, Matthieu, Fallin, M Daniele, Melén, Erik, and Prentice, Andrew M

Subjects
Fetus, Humans, Prenatal Exposure Delayed Effects, Birth Weight, Folic Acid, DNA, Body Mass Index, Smoking, DNA Methylation, Epigenesis, Genetic, CpG Islands, Fetal Development, Pregnancy, Genome, Human, Adolescent, Adult, Child, Infant, Newborn, Female, Male, Genome-Wide Association Study, Epigenesis, Genetic, Genome, Human, Infant, Newborn
Abstract

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni

Published
2019

6. Biomarkers for a less invasive strategy to predict children with eosinophilic esophagitis.

Author

Thulin, Helena, Mansouri, Ladan, Altman, Maria, Merid, Simon Kebede, Lundahl, Joachim, Nilsson, Caroline, and Säfholm, Jesper

Subjects
EOSINOPHILIC esophagitis, REFERENCE values, EGG whites, BIOMARKERS, EOSINOPHILS
Abstract

Background: Noninvasive biomarkers for diagnosing and monitoring eosinophilic esophagitis (EoE) are currently lacking. This study evaluates 20 biomarkers in serum and saliva, aiming to assess their diagnostic potential in pediatric EoE patients and healthy individuals. Methods: Blood and saliva from children undergoing upper endoscopy were analyzed for biomarkers, including absolute eosinophil count (AEC), eosinophil‐derived neurotoxin (EDN), total and specific IgG4‐antibodies (sIgG4), specific IgE‐antibodies (sIgE) and 15‐hydroxyeicosatetraenoic acid (15(S)‐HETE). Some patients participated twice, forming a longitudinal cohort. The ability to use the biomarkers to predict the EoE diagnosis was evaluated. Results: Analysis from 105 children divided into active EoE, remission, and healthy, revealed elevated levels of serum biomarkers (AEC, EDN, 15(S)‐HETE, sIgG4, and sIgE) in active EoE compared to healthy individuals. A combination of biomarkers (AEC, EDN, sIgE to egg white and wheat) and symptoms showed an AUC of 0.92 in distinguishing between the three groups. We further showed that optimal cutoff values for these biomarkers could discriminate between active EoE and healthy with a sensitivity of 88% and a specificity of 100% in distinguishing EoE (active and in remission) from healthy. Longitudinally, levels of EDN, sIgG4 to Bos d 4, Bos d 5, Bos d 8, gliadin, and birch, and sIgE to milk decreased in patients progressing from active EoE to remission (p <.05). Conclusions: This study identified novel biomarkers associated with EoE and proposes a panel, together with symptoms, for effective discrimination between active EoE, EoE in remission, and healthy individuals. The findings may contribute to a less invasive diagnostic method and may be a potential surveillance tool for pediatric EoE patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Lung-function trajectories: relevance and implementation in clinical practice

Author

Melén, Erik, primary, Faner, Rosa, additional, Allinson, James P, additional, Bui, Dinh, additional, Bush, Andrew, additional, Custovic, Adnan, additional, Garcia-Aymerich, Judith, additional, Guerra, Stefano, additional, Breyer-Kohansal, Robab, additional, Hallberg, Jenny, additional, Lahousse, Lies, additional, Martinez, Fernando D, additional, Merid, Simon Kebede, additional, Powell, Pippa, additional, Pinnock, Hilary, additional, Stanojevic, Sanja, additional, Vanfleteren, Lowie E G W, additional, Wang, Gang, additional, Dharmage, Shyamali C, additional, Wedzicha, Jadwiga, additional, Agusti, Alvar, additional, Abellan, Alicia, additional, Adcock, Ian, additional, Afzal, Shoaib, additional, Alter, Peter, additional, Backman, Helena, additional, Bertels, Xander, additional, Bloom, Chloe, additional, Bønnelykke, Klaus, additional, Breyer, Marie-Kathrin, additional, Casas, Sandra, additional, Chung, Fan (Kian), additional, Colak, Yunus, additional, Cosio, Borja G., additional, Duijts, Liesbeth, additional, Fabbri, Leonardo, additional, Fontanella, Sara, additional, Fuertes, Elaine, additional, Gonzalez, Juan Ramón, additional, Granell, Raquel, additional, Hartl, Sylvia, additional, Hernandez-Pacheco, Natalia, additional, Holloway, John, additional, Jarvis, Deborah, additional, Koefoed, Hans Jacob, additional, Kole, Tessa, additional, Kumar, Ashish, additional, Langhammer, Arnulf, additional, Lindberg, Anne, additional, Llopis, Maria, additional, Maitland van der Zee, Anke-Hilse, additional, Meteran, Howraman, additional, Minelli, Cosetta, additional, Nwaru, Bright, additional, Olvera, Nuria, additional, Peralta, Gabriela, additional, Ritchie, Andrew, additional, Rönmark, Eva, additional, Ross Chapman, James, additional, Sangüesa Boix, Júlia, additional, Schikowski, Tamara, additional, Schlünssen, Vivi, additional, Shaheen, Seif, additional, Sigsgaard, Torben, additional, Standl, Marie, additional, Talaei, Mohammad, additional, Ullah, Anhar, additional, Ullman, Anders, additional, Valencia-Hernandez, Carlos, additional, van den Berge, Maarten, additional, van Dijk, Yoni, additional, Vestbo, Jørgen, additional, Vijverberg, Susanne, additional, Vikjord, Sigrid Anna, additional, Volgelmeier, Claus, additional, Vonk, Judith, additional, and Zounemat Kermani, Nazanin, additional

Published
2024
Full Text
View/download PDF

11. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Author

Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Neelon, Sara E Benjamin, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, and Nystad, Wenche

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Health Sciences, Genetics, Human Genome, Prevention, Tobacco Smoke and Health, Tobacco, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Clinical Research, 2.1 Biological and endogenous factors, Reproductive health and childbirth, Respiratory, Good Health and Well Being, Asthma, Child, Child, Preschool, Chromosome Mapping, Cleft Lip, Cleft Palate, DNA Methylation, Epigenesis, Genetic, Female, Genetic Association Studies, Humans, Infant, Infant, Newborn, Pregnancy, Smoking, White People, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2 × 10(-16)). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.

Published
2016

12. Lung-function trajectories : relevance and implementation in clinical practice

Author

Melén, Erik, Faner, Rosa, Allinson, James P, Bui, Dinh, Bush, Andrew, Custovic, Adnan, Garcia-Aymerich, Judith, Guerra, Stefano, Breyer-Kohansal, Robab, Hallberg, Jenny, Lahousse, Lies, Martinez, Fernando D, Merid, Simon Kebede, Powell, Pippa, Pinnock, Hilary, Stanojevic, Sanja, Vanfleteren, Lowie E G W, Wang, Gang, Dharmage, Shyamali C, Wedzicha, Jadwiga, Agusti, Alvar, Melén, Erik, Faner, Rosa, Allinson, James P, Bui, Dinh, Bush, Andrew, Custovic, Adnan, Garcia-Aymerich, Judith, Guerra, Stefano, Breyer-Kohansal, Robab, Hallberg, Jenny, Lahousse, Lies, Martinez, Fernando D, Merid, Simon Kebede, Powell, Pippa, Pinnock, Hilary, Stanojevic, Sanja, Vanfleteren, Lowie E G W, Wang, Gang, Dharmage, Shyamali C, Wedzicha, Jadwiga, and Agusti, Alvar

Abstract

Lung development starts in utero and continues during childhood through to adolescence, reaching its peak in early adulthood. This growth is followed by gradual decline due to physiological lung ageing. Lung-function development can be altered by several host and environmental factors during the life course. As a result, a range of lung-function trajectories exist in the population. Below average trajectories are associated with respiratory, cardiovascular, metabolic, and mental health comorbidities, as well as with premature death. This Review presents progressive research into lung-function trajectories and assists the implementation of this knowledge in clinical practice as an innovative approach to detect poor lung health early, monitor respiratory disease progression, and promote lung health. Specifically, we propose that, similar to paediatric height and weight charts used globally to monitor children's growth, lung-function charts could be used for both children and adults to monitor lung health status across the life course. To achieve this proposal, we introduce our free online Lung Function Tracker tool. Finally, we discuss challenges and opportunities for effective implementation of the trajectory concept at population level and outline an agenda for crucial research needed to support such implementation.

Published
2024

13. Arachidonic acid and docosahexaenoic acid levels correlate with the in fl ammation proteome in extremely preterm infants

Author

Klevebro, Susanna, Merid, Simon Kebede, Sjobom, Ulrika, Zhong, Wen, Danielsson, Hanna, Wackernagel, Dirk, Hansen-Pupp, Ingrid, Ley, David, Savman, Karin, Uhlen, Mathias, Smith, Lois E. H., Hellstrom, Ann, Nilsson, Anders K., Klevebro, Susanna, Merid, Simon Kebede, Sjobom, Ulrika, Zhong, Wen, Danielsson, Hanna, Wackernagel, Dirk, Hansen-Pupp, Ingrid, Ley, David, Savman, Karin, Uhlen, Mathias, Smith, Lois E. H., Hellstrom, Ann, and Nilsson, Anders K.

Abstract

Background & aim: Clinical trials supplementing the long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic acid (DHA) and arachidonic acid (AA) to preterm infants have shown positive effects on in flammation-related morbidities, but the molecular mechanisms underlying these effects are not fully elucidated. This study aimed to determine associations between DHA, AA, and in flammation-related proteins during the neonatal period in extremely preterm infants. Methods: A retrospective exploratory study of infants (n 1 / 4 183) born below 28 weeks gestation from the Mega Donna Mega trial, a randomized multicenter trial designed to study the effect of DHA and AA on retinopathy of prematurity. Serial serum samples were collected after birth until postnatal day 100 (median 7 samples per infant) and analyzed for phospholipid fatty acids and proteins using targeted proteomics covering 538 proteins. Associations over time between LCPUFAs and proteins were explored using mixed effect modeling with splines, including an interaction term for time, and adjusted for gestational age, sex, and center. Results: On postnatal day one, 55 proteins correlated with DHA levels and 10 proteins with AA levels. Five proteins were related to both fatty acids, all with a positive correlation. Over the first 100 days after birth, we identi fied 57 proteins to be associated with DHA and/or AA. Of these proteins, 41 (72%) related to in flammation. Thirty-eight proteins were associated with both fatty acids and the overall direction of association did not differ between DHA and AA, indicating that both LCPUFAs similarly contribute to upand down-regulation of the preterm neonate in flammatory proteome. Primary examples of this were the in flammation-modulating cytokines IL -6 and CCL7, both being negatively related to levels of DHA and AA in the postnatal period. Conclusions: This study supports postnatal non -antagonistic and potentially synergistic effects of DHA and AA on the inflamm, Funding Agencies|Swedish Research Council [2015-00810, 2016-01131, 2022-01562]; Swedish government [ALFGBG-71971, ALFGBG-812951]; Swedish county councils-the ALF-agreement [ALFGBG-71971, ALFGBG-812951]; Wallenberg Clinical Scholars [KAW 2018.0310]; SciLifeLab & Wallenberg Data Driven Life Science Program [KAW 2020.0239]; De Blindas Vanner [20210, 22209]; Dr Reinhard Marcuses fond [20212694]; Magnus Bergvalls stiftelse [2021-04347]; Royal Society of Arts and Sciences in Gothenburg [20210928]; Spadbarnsfonden (Swedish infant death foundation, 2022) [FoUI-969327]; Region Stockholm; Swedish Heart-Lung Foundation [20190285]; Lilla Barnets Fond [FoUI-979720]

Published
2024
Full Text
View/download PDF

15. DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Author

Xu, Cheng-Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A, Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J, Aguirre-Gamboa, Raul, de Jongste, Johan C, Smit, Henriette A, Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R C, Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C, Li, Yang, Wijmenga, Cisca, Netea, Mihai G, Moffatt, Miriam F, Cookson, William O C M, Anto, Josep M, Bousquet, Jean, Laatikainen, Tiina, Laprise, Catherine, Carlsen, Kai-Håkon, Gori, Davide, Porta, Daniela, Iñiguez, Carmen, Bilbao, Jose Ramon, Kogevinas, Manolis, Wright, John, Brunekreef, Bert, Kere, Juha, Nawijn, Martijn C, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, and Koppelman, Gerard H

Published
2018
Full Text
View/download PDF

16. Eosinophilic allergic rhinitis is strongly associated with the CD45RBlo subset of CD161+ Th2 cells that secretes IL‐2, IL‐3, IL‐4, IL‐5, IL‐9, and IL‐13

Author

Lee, Wendy W. L., primary, Puan, Kia Joo, additional, Lee, Bernett, additional, Chua, Celine, additional, Koh, Ser Mei, additional, Yusof, Nurhashikin, additional, Tan, Kim Peng, additional, Luis, Boris San, additional, Ong, Jocelyn, additional, Merid, Simon Kebede, additional, Ang, Rachel, additional, Chan, Xue Ying, additional, Hui, Low Jing, additional, Terenzani, Elisa, additional, Lum, Josephine, additional, Foo, Shihui, additional, Zolezzi, Francesca, additional, Yan, Annabelle Tay Sok, additional, Melen, Erik, additional, Yi, Soh Jian, additional, Rotzschke, Olaf, additional, and Andiappan, Anand Kumar, additional

Published
2023
Full Text
View/download PDF

19. Innate lymphoid cells type 2 and CD8+ T cells are perturbed in overweight and obese individuals with asthma

Author

Björkander, Sophia, primary, Maier, Paul, additional, Kere, Maura, additional, Merid, Simon Kebede, additional, Wirth, Lorenz, additional, Wiegel, Whitney, additional, Ekström, Sandra, additional, Kull, Inger, additional, Bergström, Anna, additional, Melén, Erik, additional, Mjösberg, Jenny, additional, and Tibbitt, Christopher Andrew, additional

Published
2023
Full Text
View/download PDF

20. Associations of improved air quality with lung function growth from childhood to adulthood: The BAMSE study

Author

Yu, Zhebin, primary, Merid, Simon Kebede, additional, Bellander, Tom, additional, Bergström, Anna, additional, Eneroth, Kristina, additional, Georgelis, Antonios, additional, Hallberg, Jenny, additional, Kull, Inger, additional, Ljungman, Petter, additional, Klevebro, Susanna, additional, Stafoggia, Massimo, additional, Wang, Gang, additional, Pershagen, Göran, additional, Gruzieva, Olena, additional, and Melén, Erik, additional

Published
2023
Full Text
View/download PDF

21. Plasticity of Individual Lung Function States from Childhood to Adulthood

Author

Wang, Gang, Hallberg, Jenny, Faner, Rosa, Koefoed, Hans Jacob, Merid, Simon Kebede, Klevebro, Susanna, Bjorkander, Sophia, Gruzieva, Olena, Pershagen, Goran, van Hage, Marianne, Guerra, Stefano, Bottai, Matteo, Georgelis, Antonios, Gehring, Ulrike, Bergstrom, Anna, Vonk, Judith M., Kull, Inger, Koppelman, Gerard H., Agusti, Alvar, Melen, Erik, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
respiratory health, inflammation, multiple-breath washout, early life risk factors, asthma
Abstract

Rationale: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life. Objectives: To explore the plasticity of individual lung function states during childhood. Methods: Prebronchodilator FEV1 z-scores determined at age 8, 16, and 24 years in the Swedish population-based birth cohort BAMSE (Swedish abbreviation for Child [Barn], Allergy, Milieu, Stockholm, Epidemiological study) (N = 3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low or very low states to normal or high or very high states, and growth failure as moving from normal or high or very high states to low or very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA (Prevention and Incidence of Asthma and Mite Allergy) cohort. Measurements and Main Results: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low or very low states and 36 (2.4%) participants with normal or high or very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified IL-6 and CXCL10 (C-X-C motif chemokine 10) as potential biomarkers of impaired lung function development. Conclusions: Individual lung function states during childhood are plastic, including catch-up and growth failure.

Published
2023

23. Eosinophilic allergic rhinitis is strongly associated with the CD45RBlo subset of CD161+ Th2 cells that secretes IL‐2, IL‐3, IL‐4, IL‐5, IL‐9, and IL‐13.

Author

Lee, Wendy W. L., Puan, Kia Joo, Lee, Bernett, Chua, Celine, Koh, Ser Mei, Yusof, Nurhashikin, Tan, Kim Peng, Luis, Boris San, Ong, Jocelyn, Merid, Simon Kebede, Ang, Rachel, Chan, Xue Ying, Hui, Low Jing, Terenzani, Elisa, Lum, Josephine, Foo, Shihui, Zolezzi, Francesca, Yan, Annabelle Tay Sok, Melen, Erik, and Yi, Soh Jian

Subjects
TH2 cells, ALLERGIC rhinitis, ATOPY
Abstract

Allergic airway diseases such as allergic rhinitis (AR) affects more than 400 million individuals worldwide and afflicts substantial health and economic morbidity.[1] AR is strongly associated with a Type 2 response, characterized by the cytokines IL-5, IL-4, and IL-13. Thus, the severity of eosinophilic airway allergies such as AR seems to be driven by an activated terminally differentiated CD161 SP + sp Th2 subset that is able to secrete a complex set of inflammatory cytokines. Eosinophilic allergic rhinitis is strongly associated with the CD45RBlo subset of CD161+ Th2 cells that secretes IL-2, IL-3, IL-4, IL-5, IL-9, and IL-13 Scatterplots showing (D) proportion of CD161+ Th2 and (E) CD45RB expression on CD161+ Th2 comparison between non-AR and AR individuals. [Extracted from the article]

Published
2023
Full Text
View/download PDF

24. Innate lymphoid cells type 2 and CD8+ T cells are perturbed in overweight and obese individuals with asthma.

Author

Björkander, Sophia, Maier, Paul, Kere, Maura, Merid, Simon Kebede, Wirth, Lorenz, Wiegel, Whitney, Ekström, Sandra, Kull, Inger, Bergström, Anna, Melén, Erik, Mjösberg, Jenny, and Tibbitt, Christopher Andrew

Subjects
INNATE lymphoid cells, T cells, ASTHMA, OBESITY, MONONUCLEAR leukocytes
Abstract

The prevalence of asthma and obesity is increasing globally and represents a major challenge. We assessed the ILC compartment alongside T cells in 87 individuals grouped as overweight/obese asthma ( I n i = 20), normal weight asthma ( I n i = 21), overweight/obese non-asthma ( I n i = 25), and normal weight non-asthma ( I n i = 21) (Data S2 [Ethical Permit: 2020-02922]; Tables SI and SII) ([4]). [Extracted from the article]

Published
2023
Full Text
View/download PDF

25. Molecular signatures of early life exposures and complex diseases : applications using epigenetics and transcriptomics data

Author

Merid, Simon Kebede and Merid, Simon Kebede

Abstract

Environmental exposures and early life stressors may influence developmental processes and have long-term health consequences, potentially mediated by molecular mechanisms such as epigenetic modifications. The most extensively studied epigenetic mechanism is DNA methylation, which has been proposed to constitute a link between genetic and environmental factors. Epigenetic patterns established early in life (already in utero) may affect how a gene is expressed throughout life, and thereby increase susceptibility to chronic disease. Other factors like genetics and repeated airway infections also influence disease risk. Chronic obstructive pulmonary disease (COPD) is a complex disease considered a major global health problem, with tobacco smoking being one of the main risk factors. The role that deoxyribonucleic acid (DNA) methylation might play in the pathogenesis of COPD has not been comprehensively studied. Bronchoalveolar lavage (BAL) cells from the airways and alveolar space are considered key targets for COPD. Peanut allergy is another complex disease – one of the most common food allergies and the leading cause of anaphylaxis among children. Peanut oral immunotherapy (pOIT) can lead to desensitization and tolerance, and combined treatment with anti-immunoglobulin E (IgE) using omalizumab may facilitate oral immunotherapy initiation. The mechanisms of oral immunotherapy-induced tolerance, including possible changes at the transcriptional level, are not well understood. The main aim of this thesis was to identify molecular signatures of early-life exposures, chronic respiratory disease, as well as allergy treatment responses. In Study I, the association between gestational age and DNA methylation patterns (at 5´-cytosine-phosphate-guanine-3´ sites, CpGs, across the genome) was investigated in newborns and older children from the large The Pregnancy And Childhood Epigenetics (PACE) consortium meta-analysis, including 11,000 participants in 26 independent cohorts. C

Published
2022

27. Creatine Kinase Is Decreased in Childhood Asthma.

Author

Guerra, Stefano, Ledford, Julie G., Melén, Erik, Lavi, Iris, Carsin, Anne-Elie, Stern, Debra A., Zhai, Jing, Vidal, Marta, Bustamante, Mariona, Addison, Kenneth J., Vallecillo, Renata G., Billheimer, Dean, Koppelman, Gerard H., Garcia-Aymerich, Judith, Lemonnier, Nathanaël, Fitó, Montserrat, Dobaño, Carlota, Merid, Simon Kebede, Kull, Inger, and McEachan, Rosemary R. C.

Abstract

The article offers several studies that have assessed various protein panels in asthma with most using airway-derived samples, recruiting clinic-based cohorts and focuses on cytokines and chemokines. Topics include examines there is a lack of large-scale population-based studies that examine multiple circulating proteins for association with asthma in children.

Published
2023
Full Text
View/download PDF

28. Plasticity of Individual Lung Function States from Childhood to Adulthood.

Author

Gang Wang, Hallberg, Jenny, Faner, Rosa, Koefoed, Hans-Jacob, Merid, Simon Kebede, Klevebro, Susanna, Bjorkander, Sophia, Gruzieva, Olena, Pershagen, Goran, Hage, Marianne van, Guerra, Stefano, Bottai, Matteo, Georgelis, Antonios, Gehring, Ulrike, Bergstrom, Anna, Vonk, Judith M., Kull, Inger, Koppelman, Gerard H., Agusti, Alvar, and Melen, Erik

Subjects
LUNGS, LUNG development, ADULTS, CHILD development, CHEMOKINES
Abstract

Rationale: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life.Objectives: To explore the plasticity of individual lung function states during childhood.Methods: Pre-bronchodilator FEV1 z-scores determined at age 8, 16 and 24 years in the Swedish population-based birth cohort BAMSE (N=3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low/very low states to normal/high/very high states, and growth failure as moving from normal/high/very high states to low/very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA cohort.Measurements and Main Results: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low/very low states and 36 (2.4%) participants with normal/high/very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified Interleukin-6 and C-X-C motif chemokine 10 as potential biomarkers of impaired lung function development.Conclusions: Individual lung function states during childhood are plastic, including catch-up and growth failure. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

30. Transcriptome changes during peanut oral immunotherapy and omalizumab treatment

Author

Björkander, Sophia, primary, Merid, Simon Kebede, additional, Brodin, David, additional, Brandström, Josef, additional, Fagerström‐Billai, Fredrik, additional, van der Heiden, Marieke, additional, Konradsen, Jon R., additional, Kabesch, Michael, additional, van Drunen, Cornelis M., additional, Golebski, Korneliusz, additional, Maitland‐van der Zee, Anke H., additional, Potočnik, Uroš, additional, Vijverberg, Susanne J. H., additional, Nopp, Anna, additional, Nilsson, Caroline, additional, and Melén, Erik, additional

Published
2021
Full Text
View/download PDF

31. Investigation of gene expression in relation to omalizumab treatment and peanut oral immunotherapy

Author

Merid, Simon Kebede, primary, Björkander, Sophia, additional, Brodin, David, additional, Brandström, Josef, additional, Fagerström-Billai, Fredrik, additional, Van Der Heiden, Marieke, additional, Konradsen, Jon, additional, Kabesch, Michael, additional, Van Drunen, Cornelis, additional, Kornel, Golebski, additional, Maitland-Van Der Zee, Anke H, additional, Potočnik, Uroš, additional, Vijverberg, Vijverberg J H, additional, Nopp, Anna, additional, Nilsson, Caroline, additional, and Melén, Erik, additional

Published
2021
Full Text
View/download PDF

32. Longitudinal modelling of lung function trajectories from childhood to early adulthood in the BAMSE cohort

Author

Wang, Gang, primary, Hallberg, Jenny, additional, Merid, Simon Kebede, additional, Klevebro, Susanna, additional, Björkander, Sophia, additional, Gruzieva, Olena, additional, Faner, Rosa, additional, Agusti, Alvar, additional, Bottai, Matteo, additional, Georgellis, Antonis, additional, Bergström, Anna, additional, Kull, Inger, additional, and Melén, Erik, additional

Published
2021
Full Text
View/download PDF

33. Transcriptome changes during peanut oral immunotherapy and omalizumab treatment

Author

Bjorkander, Sofia, primary, Merid, Simon Kebede, additional, Brodin, David, additional, Brandstrom, Josef, additional, Fagerstrom-billai, Fredrik, additional, Heiden, Marieke van der, additional, Konradsen, Jon, additional, Kabesch, Michael, additional, Drunen, Cornelis, additional, Golebski, Korneliusz, additional, Zee, Anke-Hilse Maitland - van der, additional, Potocnik, Uros, additional, Vijverberg, Susanne, additional, Nopp, Anna, additional, Nilsson, Caroline, additional, and Melén, Erik, additional

Published
2021
Full Text
View/download PDF

34. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Author

Merid, Simon Kebede, Novoloaca, Alexei, Sharp, Gemma C, Küpers, Leanne K, Kho, Alvin T, Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne O, Kazmi, Nabila, Salas, Lucas A, Rezwan, Faisal I, Zhang, Hongmei, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl L, Melton, Phillip E, Lawlor, Debbie A, Pershagen, Göran, Breton, Carrie V, Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim S, Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen Aagaard, Bustamante, Mariona, Ewart, Susan L, Karmaus, Wilfried, Zhao, Shanshan, Page, Christian M, Herceg, Zdenko, Jarvelin, Marjo-Riitta, Lahti, Jari, Baccarelli, Andrea A, Anderson, Denise, Kachroo, Priyadarshini, Relton, Caroline L, Bergström, Anna, Eskenazi, Brenda, Soomro, Munawar Hussain, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent W, Sørensen, Thorkild I A, Vrijheid, Martine, Arshad, S Hasan, Holloway, John W, Håberg, Siri E, Magnus, Per, Dwyer, Terence, Binder, Elisabeth B, DeMeo, Dawn L, Vonk, Judith M, Newnham, John, Tantisira, Kelan G, Kull, Inger, Wiemels, Joseph L, Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica C, Räikkönen, Katri, Oken, Emily, Huang, Rae-Chi, Weiss, Scott T, Antó, Josep Maria, Bousquet, Jean, Kumar, Ashish, Söderhäll, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah E, Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Hivert, Marie-France, Felix, Janine F, Koppelman, Gerard H, London, Stephanie J, Melén, Erik, Merid, Simon Kebede, Novoloaca, Alexei, Sharp, Gemma C, Küpers, Leanne K, Kho, Alvin T, Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne O, Kazmi, Nabila, Salas, Lucas A, Rezwan, Faisal I, Zhang, Hongmei, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl L, Melton, Phillip E, Lawlor, Debbie A, Pershagen, Göran, Breton, Carrie V, Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim S, Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen Aagaard, Bustamante, Mariona, Ewart, Susan L, Karmaus, Wilfried, Zhao, Shanshan, Page, Christian M, Herceg, Zdenko, Jarvelin, Marjo-Riitta, Lahti, Jari, Baccarelli, Andrea A, Anderson, Denise, Kachroo, Priyadarshini, Relton, Caroline L, Bergström, Anna, Eskenazi, Brenda, Soomro, Munawar Hussain, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent W, Sørensen, Thorkild I A, Vrijheid, Martine, Arshad, S Hasan, Holloway, John W, Håberg, Siri E, Magnus, Per, Dwyer, Terence, Binder, Elisabeth B, DeMeo, Dawn L, Vonk, Judith M, Newnham, John, Tantisira, Kelan G, Kull, Inger, Wiemels, Joseph L, Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica C, Räikkönen, Katri, Oken, Emily, Huang, Rae-Chi, Weiss, Scott T, Antó, Josep Maria, Bousquet, Jean, Kumar, Ashish, Söderhäll, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah E, Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Hivert, Marie-France, Felix, Janine F, Koppelman, Gerard H, London, Stephanie J, and Melén, Erik

Abstract

Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods: We performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results: We identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P < 1.06 × 10- 7, of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions: We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.

Published
2021

35. Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure

Author

Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Merid, Simon Kebede, Bustamante, Mariona, Standl, Marie, Sunyer, Jordi, Heinrich, Joachim, Lemonnier, Nathanael, Aguilar, Daniel, Antó, Josep Maria, Bousquet, Jean, Santa Marina, Loreto, Lertxundi Manterola, Aitana, Bergstrom, Anna, Kull, Inger, Wheelock, Asa M., Koppelman, Gerard H., Melen, Erik, Gruzieva, Olena, Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Merid, Simon Kebede, Bustamante, Mariona, Standl, Marie, Sunyer, Jordi, Heinrich, Joachim, Lemonnier, Nathanael, Aguilar, Daniel, Antó, Josep Maria, Bousquet, Jean, Santa Marina, Loreto, Lertxundi Manterola, Aitana, Bergstrom, Anna, Kull, Inger, Wheelock, Asa M., Koppelman, Gerard H., Melen, Erik, and Gruzieva, Olena

Abstract

Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this meta-analysis of transcriptome-wide association studies of 656 children and adolescents from three European cohorts participating in the MeDALL Consortium, we found two differentially expressed transcript clusters (FDR p < 0.05) associated with exposure to particulate matter < 2.5 mu m in diameter (PM2.5) at birth, one of them mapping to the MIR1296 gene. Further, by integrating gene expression with DNA methylation using Functional Epigenetic Modules algorithms, we identified 9 and 6 modules in relation to PM2.5 exposure at birth and at current address, respectively (including NR1I2, MAPK6, TAF8 and SCARA3). In conclusion, PM2.5 exposure at birth was linked to differential gene expression in children and adolescents. Importantly, we identified several significant interactome hotspots of gene modules of relevance for complex diseases in relation to PM2.5 exposure.

Published
2021

36. Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care

Author

Klevebro, Susanna, primary, Bahram, Fuad, additional, Elfström, K. Miriam, additional, Hellberg, Ulrika, additional, Hober, Sophia, additional, Merid, Simon Kebede, additional, Kull, Inger, additional, Nilsson, Peter, additional, Tornvall, Per, additional, Wang, Gang, additional, Lundgren, Kalle Conneryd, additional, Ponzer, Sari, additional, Dillner, Joakim, additional, and Melén, Erik, additional

Published
2021
Full Text
View/download PDF

38. DNA Methylation Levels in Mononuclear Leukocytes from the Mother and Her Child Are Associated with IgE Sensitization to Allergens in Early Life

Author

Acevedo, Nathalie, primary, Scala, Giovanni, additional, Merid, Simon Kebede, additional, Frumento, Paolo, additional, Bruhn, Sören, additional, Andersson, Anna, additional, Ogris, Christoph, additional, Bottai, Matteo, additional, Pershagen, Göran, additional, Koppelman, Gerard H., additional, Melén, Erik, additional, Sonnhammer, Erik, additional, Alm, Johan, additional, Söderhäll, Cilla, additional, Kere, Juha, additional, Greco, Dario, additional, and Scheynius, Annika, additional

Published
2021
Full Text
View/download PDF

39. Additional file 1 of Changes of DNA methylation are associated with changes in lung function during adolescence

Author

Sunny, Shadia Khan, Hongmei Zhang, Rezwan, Faisal I., Relton, Caroline L., A. John Henderson, Merid, Simon Kebede, Melén, Erik, Hallberg, Jenny, S. Hasan Arshad, Ewart, Susan, and Holloway, John W.

Subjects
sense organs, respiratory system, skin and connective tissue diseases, circulatory and respiratory physiology, respiratory tract diseases
Abstract

Additional file 1 Table S1. List of CpGs (k = 42) at which changes of DNA-M were significantly associated with changes of FEV1/FVC in females in IOW cohort and examined among the females in ALSPAC and BAMSE cohorts.

Published
2020
Full Text
View/download PDF

40. Transcriptome changes during peanut oral immunotherapy and omalizumab treatment.

Author

Björkander, Sophia, Merid, Simon Kebede, Brodin, David, Brandström, Josef, Fagerström‐Billai, Fredrik, van der Heiden, Marieke, Konradsen, Jon R., Kabesch, Michael, van Drunen, Cornelis M., Golebski, Korneliusz, Maitland‐van der Zee, Anke H., Potočnik, Uroš, Vijverberg, Susanne J. H., Nopp, Anna, Nilsson, Caroline, Melén, Erik, and Peters, Rachel

Subjects
*PEANUT allergy, *OMALIZUMAB, *FARNESOID X receptor, *PEANUTS, *REGULATORY T cells, *TRANSCRIPTOMES
Abstract

We thank all FASTX patients for their participation and the research staff at Forskningscentrum, Södersjukhuset. All participants then underwent an open peanut challenge (pOIT start), before starting peanut OIT (pOIT) in combination with continued omalizumab treatment. The x-axis shows the gene ratio of the overlapping genes of our gene list with the pathway gene set. [Extracted from the article]

Published
2022
Full Text
View/download PDF

41. Supplementary_table_1 – Supplemental material for DNA Methylation Trajectories During Pregnancy

Author

Gruzieva, Olena, Merid, Simon Kebede, Chen, Su, Mukherjee, Nandini, Hedman, Anna M, Almqvist, Catarina, Ellika Andolf, Jiang, Yu, Kere, Juha, Scheynius, Annika, Söderhäll, Cilla, Ullemar, Vilhelmina, Karmaus, Wilfried, Melén, Erik, Arshad, Syed Hasan, and Pershagen, Göran

Subjects
Cell Biology
Abstract

Supplemental material, Supplementary_table_1 for DNA Methylation Trajectories During Pregnancy by Olena Gruzieva, Simon Kebede Merid, Su Chen, Nandini Mukherjee, Anna M Hedman, Catarina Almqvist, Ellika Andolf, Yu Jiang, Juha Kere, Annika Scheynius, Cilla Söderhäll, Vilhelmina Ullemar, Wilfried Karmaus, Erik Melén, Syed Hasan Arshad and Göran Pershagen in Epigenetics Insights

Published
2019
Full Text
View/download PDF

43. Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis

Author

Gruzieva, Olena, Xu, Cheng-Jian, Yousefi, Paul, Relton, Caroline, Merid, Simon Kebede, Breton, Carrie V, Gao, Lu, Volk, Heather E, Feinberg, Jason I, Ladd-Acosta, Christine, Bakulski, Kelly, Auffray, Charles, Lemonnier, Nathanaël, Plusquin, Michelle, Ghantous, Akram, Herceg, Zdenko, Nawrot, Tim S, Pizzi, Costanza, Richiardi, Lorenzo, Rusconi, Franca, Vineis, Paolo, Kogevinas, Manolis, Felix, Janine F, Duijts, Liesbeth, den Dekker, Herman T, Jaddoe, Vincent W V, Ruiz, José L, Bustamante, Mariona, Antó, Josep Maria, Sunyer, Jordi, Vrijheid, Martine, Gutzkow, Kristine B, Grazuleviciene, Regina, Hernandez-Ferrer, Carles, Annesi-Maesano, Isabella, Lepeule, Johanna, Bousquet, Jean, Bergström, Anna, Kull, Inger, Söderhäll, Cilla, Kere, Juha, Gehring, Ulrike, Brunekreef, Bert, Just, Allan C, Wright, Rosalind J, Peng, Cheng, Gold, Diane R, Kloog, Itai, DeMeo, Dawn L, Pershagen, Göran, Gruzieva, Olena, Xu, Cheng-Jian, Yousefi, Paul, Relton, Caroline, Merid, Simon Kebede, Breton, Carrie V, Gao, Lu, Volk, Heather E, Feinberg, Jason I, Ladd-Acosta, Christine, Bakulski, Kelly, Auffray, Charles, Lemonnier, Nathanaël, Plusquin, Michelle, Ghantous, Akram, Herceg, Zdenko, Nawrot, Tim S, Pizzi, Costanza, Richiardi, Lorenzo, Rusconi, Franca, Vineis, Paolo, Kogevinas, Manolis, Felix, Janine F, Duijts, Liesbeth, den Dekker, Herman T, Jaddoe, Vincent W V, Ruiz, José L, Bustamante, Mariona, Antó, Josep Maria, Sunyer, Jordi, Vrijheid, Martine, Gutzkow, Kristine B, Grazuleviciene, Regina, Hernandez-Ferrer, Carles, Annesi-Maesano, Isabella, Lepeule, Johanna, Bousquet, Jean, Bergström, Anna, Kull, Inger, Söderhäll, Cilla, Kere, Juha, Gehring, Ulrike, Brunekreef, Bert, Just, Allan C, Wright, Rosalind J, Peng, Cheng, Gold, Diane R, Kloog, Itai, DeMeo, Dawn L, and Pershagen, Göran

Abstract

BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes.OBJECTIVES: We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter [Formula: see text] ([Formula: see text]) or [Formula: see text] ([Formula: see text]) and DNA methylation in newborns and children.METHODS: We meta-analyzed associations between exposure to [Formula: see text] ([Formula: see text]) and [Formula: see text] ([Formula: see text]) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression.RESULTS: Six CpGs were significantly associated [false discovery rate (FDR) [Formula: see text]] with prenatal [Formula: see text] and 14 with [Formula: see text] exposure. Two of the [Formula: see text] CpGs mapped to FAM13A (cg00905156) and NOTCH4 (cg06849931) previously associated with lung function and asthma. Although these associations did not replicate in the smaller newborn sample, both CpGs were significant ([Formula: see text]) in 7- to 9-y-olds. For cg06849931, however, the direction of the association was inconsistent. Concurrent [Formula: see text] exposure was associated with a significantly higher NOTCH4 expression at age 16 y. We also identified several DMRs associated with either prenatal [Formula: see text] and or [Formula: see text] exposure, of which two [Formula: see text] DMRs, including H19 and MARCH11, replicated in newborns.CONCLUSIONS: Several differentially methylated CpGs an

Published
2019

44. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Author

Kupers, Leanne K., Monnereau, Claire, Sharp, Gemma C., Yousefi, Paul, Salas, Lucas A., Ghantous, Akram, Page, Christian M., Reese, Sarah E., Wilcox, Allen J., Czamara, Darina, Starling, Anne P., Novoloaca, Alexei, Lent, Samantha, Roy, Ritu, Hoyo, Cathrine, Breton, Carrie, V, Allard, Catherine, Just, Allan C., Bakulski, Kelly M., Holloway, John W., Everson, Todd M., Xu, Cheng-Jian, Huang, Rae-Chi, van der Plaat, Diana A., Wielscher, Matthias, Merid, Simon Kebede, Ullemar, Vilhelmina, Rezwan, Faisal, I, Lahti, Jari, van Dongen, Jenny, Langie, Sabine A. S., Richardson, Tom G., Magnus, Maria C., Nohr, Ellen A., Xu, Zongli, Duijts, Liesbeth, Zhao, Shanshan, Zhang, Weiming, Plusquin, Michelle, DeMeo, Dawn L., Solomon, Olivia, Heimovaara, Joosje H., Jima, Dereje D., Gao, Lu, Bustamante, Mariona, Perron, Patrice, Wright, Robert O., Hertz-Picciotto, Irva, Zhang, Hongmei, Karagas, Margaret R., Gehring, Ulrike, Marsit, Carmen J., Beilin, Lawrence J., Vonk, Judith M., Jarvelin, Marjo-Riitta, Bergstrom, Anna, Ortqvist, Anne K., Ewart, Susan, Villa, Pia M., Moore, Sophie E., Willemsen, Gonneke, Standaert, Arnout R. L., Haberg, Siri E., Sørensen, Thorkild I. A., Taylor, Jack A., Raikkonen, Katri, Yang, Ivana, V, Kechris, Katerina, Nawrot, Tim S., Silver, Matt J., Gong, Yun Yun, Richiardi, Lorenzo, Kogevinas, Manolis, Litonjua, Augusto A., Eskenazi, Brenda, Huen, Karen, Mbarek, Hamdi, Maguire, Rachel L., Dwyer, Terence, Vrijheid, Martine, Bouchard, Luigi, Baccarelli, Andrea A., Croen, Lisa A., Karmaus, Wilfried, Anderson, Denise, de Vries, Maaike, Sebert, Sylvain, Kere, Juha, Karlsson, Robert, Arshad, Syed Hasan, Hamalainen, Esa, Routledge, Michael N., Boomsma, Dorret, I, Feinberg, Andrew P., Newschaffer, Craig J., Govarts, Eva, Moisse, Matthieu, Fallin, M. Daniele, Melen, Erik, Prentice, Andrew M., Kajantie, Eero, Almqvist, Catarina, Oken, Emily, Dabelea, Dana, Boezen, H. Marike, Melton, Phillip E., Wright, Rosalind J., Koppelman, Gerard H., Trevisi, Letizia, Hivert, Marie-France, Sunyer, Jordi, Munthe-Kaas, Monica C., Murphy, Susan K., Corpeleijn, Eva, Wiemels, Joseph, Holland, Nina, Herceg, Zdenko, Binder, Elisabeth B., Smith, George Davey, Jaddoe, Vincent W. V., Lie, Rolv T., Nystad, Wenche, London, Stephanie J., Lawlor, Debbie A., Relton, Caroline L., Snieder, Harold, Felix, Janine F., Kupers, Leanne K., Monnereau, Claire, Sharp, Gemma C., Yousefi, Paul, Salas, Lucas A., Ghantous, Akram, Page, Christian M., Reese, Sarah E., Wilcox, Allen J., Czamara, Darina, Starling, Anne P., Novoloaca, Alexei, Lent, Samantha, Roy, Ritu, Hoyo, Cathrine, Breton, Carrie, V, Allard, Catherine, Just, Allan C., Bakulski, Kelly M., Holloway, John W., Everson, Todd M., Xu, Cheng-Jian, Huang, Rae-Chi, van der Plaat, Diana A., Wielscher, Matthias, Merid, Simon Kebede, Ullemar, Vilhelmina, Rezwan, Faisal, I, Lahti, Jari, van Dongen, Jenny, Langie, Sabine A. S., Richardson, Tom G., Magnus, Maria C., Nohr, Ellen A., Xu, Zongli, Duijts, Liesbeth, Zhao, Shanshan, Zhang, Weiming, Plusquin, Michelle, DeMeo, Dawn L., Solomon, Olivia, Heimovaara, Joosje H., Jima, Dereje D., Gao, Lu, Bustamante, Mariona, Perron, Patrice, Wright, Robert O., Hertz-Picciotto, Irva, Zhang, Hongmei, Karagas, Margaret R., Gehring, Ulrike, Marsit, Carmen J., Beilin, Lawrence J., Vonk, Judith M., Jarvelin, Marjo-Riitta, Bergstrom, Anna, Ortqvist, Anne K., Ewart, Susan, Villa, Pia M., Moore, Sophie E., Willemsen, Gonneke, Standaert, Arnout R. L., Haberg, Siri E., Sørensen, Thorkild I. A., Taylor, Jack A., Raikkonen, Katri, Yang, Ivana, V, Kechris, Katerina, Nawrot, Tim S., Silver, Matt J., Gong, Yun Yun, Richiardi, Lorenzo, Kogevinas, Manolis, Litonjua, Augusto A., Eskenazi, Brenda, Huen, Karen, Mbarek, Hamdi, Maguire, Rachel L., Dwyer, Terence, Vrijheid, Martine, Bouchard, Luigi, Baccarelli, Andrea A., Croen, Lisa A., Karmaus, Wilfried, Anderson, Denise, de Vries, Maaike, Sebert, Sylvain, Kere, Juha, Karlsson, Robert, Arshad, Syed Hasan, Hamalainen, Esa, Routledge, Michael N., Boomsma, Dorret, I, Feinberg, Andrew P., Newschaffer, Craig J., Govarts, Eva, Moisse, Matthieu, Fallin, M. Daniele, Melen, Erik, Prentice, Andrew M., Kajantie, Eero, Almqvist, Catarina, Oken, Emily, Dabelea, Dana, Boezen, H. Marike, Melton, Phillip E., Wright, Rosalind J., Koppelman, Gerard H., Trevisi, Letizia, Hivert, Marie-France, Sunyer, Jordi, Munthe-Kaas, Monica C., Murphy, Susan K., Corpeleijn, Eva, Wiemels, Joseph, Holland, Nina, Herceg, Zdenko, Binder, Elisabeth B., Smith, George Davey, Jaddoe, Vincent W. V., Lie, Rolv T., Nystad, Wenche, London, Stephanie J., Lawlor, Debbie A., Relton, Caroline L., Snieder, Harold, and Felix, Janine F.

Published
2019

45. DNA Methylation Trajectories During Pregnancy

Author

Gruzieva, Olena, primary, Merid, Simon Kebede, additional, Chen, Su, additional, Mukherjee, Nandini, additional, Hedman, Anna M, additional, Almqvist, Catarina, additional, Andolf, Ellika, additional, Jiang, Yu, additional, Kere, Juha, additional, Scheynius, Annika, additional, Söderhäll, Cilla, additional, Ullemar, Vilhelmina, additional, Karmaus, Wilfried, additional, Melén, Erik, additional, Arshad, Syed Hasan, additional, and Pershagen, Göran, additional

Published
2019
Full Text
View/download PDF

46. Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Author

Turner, Steve, primary, Francis, Ben, additional, Wani, Nuha, additional, Vijverberg, Susanne, additional, Pino-Yanes, Maria, additional, Mukhopadhyay, Somnath, additional, Tavendale, Roger, additional, Palmer, Colin, additional, Burchard, Esteban G, additional, Merid, Simon Kebede, additional, Melén, Erik, additional, Maitland-van der Zee, Anke H, additional, and the Pharmacogenomics in Childhood Asthma Consortium, on behalf of, additional

Published
2018
Full Text
View/download PDF

47. DNA methylation in childhood asthma : an epigenome-wide meta-analysis

Author

Xu, Cheng Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C.Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A., Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J., Aguirre-Gamboa, Raul, de Jongste, Johan C., Smit, Henriette A., Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R.C., Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Moffatt, Miriam F., Cookson, William O.C.M., Anto, Josep M., Brunekreef, Bert, the BIOS Consortium, Xu, Cheng Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C.Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A., Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J., Aguirre-Gamboa, Raul, de Jongste, Johan C., Smit, Henriette A., Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R.C., Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Moffatt, Miriam F., Cookson, William O.C.M., Anto, Josep M., Brunekreef, Bert, and the BIOS Consortium

Published
2018

48. DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Author

One Health Chemisch, dIRAS RA-2, Xu, Cheng-Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A, Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J, Aguirre-Gamboa, Raul, de Jongste, Johan C, Smit, Henriette A, Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R C, Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, the BIOS Consortium, van der Vlies, Pieter, van Diemen, Cleo C, Li, Yang, Wijmenga, Cisca, Netea, Mihai G, Moffatt, Miriam F, Cookson, William O C M, Anto, Josep M, Bousquet, Jean, Laatikainen, Tiina, Laprise, Catherine, Carlsen, Kai-Hakon, Gori, Davide, Porta, Daniela, Iñiguez, Carmen, Bilbao, Jose Ramon, Kogevinas, Manolis, Wright, John, Brunekreef, Bert, Kere, Juha, Nawijn, Martijn C, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Koppelman, Gerard H, One Health Chemisch, dIRAS RA-2, Xu, Cheng-Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A, Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J, Aguirre-Gamboa, Raul, de Jongste, Johan C, Smit, Henriette A, Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R C, Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, the BIOS Consortium, van der Vlies, Pieter, van Diemen, Cleo C, Li, Yang, Wijmenga, Cisca, Netea, Mihai G, Moffatt, Miriam F, Cookson, William O C M, Anto, Josep M, Bousquet, Jean, Laatikainen, Tiina, Laprise, Catherine, Carlsen, Kai-Hakon, Gori, Davide, Porta, Daniela, Iñiguez, Carmen, Bilbao, Jose Ramon, Kogevinas, Manolis, Wright, John, Brunekreef, Bert, Kere, Juha, Nawijn, Martijn C, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, and Koppelman, Gerard H

Published
2018

49. DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Author

Public Health Epidemiologie, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 3, Xu, Cheng Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C.Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A., Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J., Aguirre-Gamboa, Raul, de Jongste, Johan C., Smit, Henriette A., Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R.C., Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Moffatt, Miriam F., Cookson, William O.C.M., Anto, Josep M., Brunekreef, Bert, the BIOS Consortium, Public Health Epidemiologie, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 3, Xu, Cheng Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C.Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A., Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J., Aguirre-Gamboa, Raul, de Jongste, Johan C., Smit, Henriette A., Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R.C., Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Moffatt, Miriam F., Cookson, William O.C.M., Anto, Josep M., Brunekreef, Bert, and the BIOS Consortium

Published
2018

50. Exposure to traffic-related air pollution and serum inflammatory cytokines in children

Author

Gruzieva, Olena, Merid, Simon Kebede, Gref, Anna, Gajulapuri, Ashwini, Lemonnier, Nathanael, Ballereau, Stephane, Gigante, Bruna, Kere, Juha, Auffray, Charles, Melen, Erik, and Pershagen, Goran

Subjects
Air pollution -- Analysis, Cytokines -- Research, Child health -- Analysis, Gene expression -- Analysis -- Research, Environmental issues, Health
Abstract

BACKGROUND: Long-term exposure to ambient air pollution can lead to adverse health effects in children; however, underlying biological mechanisms are not fully understood. OBJECTIVES: We evaluated the effect of air pollution exposure during different time periods on mRNA expression as well as circulating levels of inflammatory cytokines in children. METHODS: We measured a panel of 10 inflammatory markers in peripheral blood samples from 670 8-y-old children in the Barn/Child, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) birth cohort. Outdoor concentrations of nitrogen dioxide (N[O.sub.2]) and particulate matter (PM) with aerodynamic diameter RESULTS: A 10 [micro]g/[m.sup.3] increase of N[O.sub.2] exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma. However, no clear associations were observed for current exposure. Results were similar using [PM.sub.10], which showed a high correlation with N[O.sub.2]. The functional analysis identified several differentially expressed genes in response to air pollution exposure during infancy, including IL10, IL13, and TNF. CONCLUSION: Our results indicate alterations in systemic inflammatory markers in 8-y-old children in relation to early-life exposure to traffic-related air pollution. https://doi.org/10.1289/EHP460., Introduction Air pollution exposure has been related to an increased risk of respiratory and allergic disorders in children (Gehring et al. 2015; Nordling et al. 2008; Schultz et al. 2016). [...]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results