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Background: Monitoring the effect of medication by using an objective measure would bring new perspectives to the work with patients suffering from Attention Deficit Hyperactivity Disorder (ADHD). Objective: In order to objectify and monitor treatment efficiency, a Continuous Performance Test (the QB Test) was used and evaluated in daily clinical practice. Method: A total of 12 boys aged 8-12 fulfilling diagnostic criteria for ADHD were tested using the QB Test before and after intake of methylphenidate. Findings: One hour after intake of test dose of medicine, there were significant improvements on numbers of omissions (p=0.014), reaction time (p=0.038), correct responses (p=0.031) and activity (p=0.045). Nonsignificant improvements in reaction time variability (p=0.190) and correct non-responses (p=0.764) were found. Number of guesses and errors of commission were unchanged after medication. Conclusions: The QB Test can be used to track effects of medication, showing greatest improvement in the most inattentive and hyperactive/impulsive children.