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25 results on '"Mercier-Nomé, Françoise"'

1. Essential Role of the RIα Subunit of cAMP-Dependent Protein Kinase in Regulating Cardiac Contractility and Heart Failure Development

Author

Bedioune, Ibrahim, Gandon-Renard, Marine, Dessillons, Matthieu, Barthou, Aurélien, Varin, Audrey, Mika, Delphine, Bichali, Saïd, Cellier, Joffrey, Lechène, Patrick, Karam, Sarah, Dia, Maya, Gomez, Susana, Pereira de Vasconcelos, Walma, Mercier-Nomé, Françoise, Mateo, Philippe, Dubourg, Audrey, Stratakis, Constantine A., Mercadier, Jean-Jacques, Benitah, Jean-Pierre, Algalarrondo, Vincent, Leroy, Jérôme, Fischmeister, Rodolphe, Gomez, Ana-Maria, and Vandecasteele, Grégoire

Published
2024
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4. Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer

Author

Timaxian, Colin, Vogel, Christoph FA, Orcel, Charlotte, Vetter, Diana, Durochat, Camille, Chinal, Clarisse, NGuyen, Phuong, Aknin, Marie-Laure, Mercier-Nomé, Françoise, Davy, Martin, Raymond-Letron, Isabelle, Van, Thi-Nhu-Ngoc, Diermeier, Sarah D, Godefroy, Anastasia, Gary-Bobo, Magali, Molina, Franck, Balabanian, Karl, and Lazennec, Gwendal

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Breast Cancer, Women's Health, Cancer, chemokine receptors, breast cancer, Cxcr2, neutrophils, tumor microenvironment, Oncology and carcinogenesis
Abstract

Chemokines present in the tumor microenvironment are essential for the control of tumor progression. We show here that several ligands of the chemokine receptor Cxcr2 were up-regulated in the PyMT (polyoma middle T oncogene) model of breast cancer. Interestingly, the knock-down of Cxcr2 in PyMT animals led to an increased growth of the primary tumor and lung metastasis. The analysis of tumor content of PyMT-Cxcr2-/- animals highlighted an increased infiltration of tumor associated neutrophils (TANs), mirrored by a decreased recruitment of tumor associated macrophages (TAMs) compared to PyMT animals. Analysis of PyMT-Cxcr2-/- TANs revealed that they lost their killing ability compared to PyMT-Cxcr2+/+ TANs. The transcriptomic analysis of PyMT-Cxcr2-/- TANs showed that they had a more pronounced pro-tumor TAN2 profile compared to PyMT TANs. In particular, PyMT-Cxcr2-/- TANs displayed an up-regulation of the pathways involved in reactive oxygen species (ROS) production and angiogenesis and factors favoring metastasis, but reduced apoptosis. In summary, our data reveal that a lack of Cxcr2 provides TANs with pro-tumor effects.

Published
2021

8. CXCR4 Antagonist in HPV5-Associated Perianal Squamous-Cell Carcinoma

Author

Marin-Esteban, Viviana, primary, Molet, Lucie, additional, Laganà, Marta, additional, Ciocan, Dragos, additional, Dominguez-Lafage, Clément, additional, Alouche, Nagham, additional, Nguyen, Julie, additional, Gallego, Carmen, additional, Mercier-Nomé, Françoise, additional, Jaracz-Ros, Agnieszka, additional, Beaupain, Blandine, additional, Bouligand, Jérôme, additional, Proust, Alexis, additional, Habib, Christophe, additional, Bonnin, Rémy A., additional, Girlich, Delphine, additional, Fouyssac, Fanny, additional, Schmutz, Jean-Luc, additional, Bursztejn, Anne-Claire, additional, Bellanné-Chantelot, Christine, additional, Bourrat, Emmanuelle, additional, Herfs, Michael, additional, Espéli, Marion, additional, Balabanian, Karl, additional, Schlecht-Louf, Géraldine, additional, Donadieu, Jean, additional, Bachelerie, Françoise, additional, and Deback, Claire, additional

Published
2024
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10. Reprogramming of connexin landscape fosters fast gap junction intercellular communication in human papillomavirus-infected epithelia

Author

Gallego, Carmen, primary, Jaracz-Ros, Agnieszka, additional, Laganà, Marta, additional, Mercier-Nomé, Françoise, additional, Domenichini, Séverine, additional, Fumagalli, Amos, additional, Roingeard, Philippe, additional, Herfs, Michael, additional, Pidoux, Guillaume, additional, Bachelerie, Françoise, additional, and Schlecht-Louf, Géraldine, additional

Published
2023
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11. Beneficial effects of a cardiac gene therapy with phosphodiesterase pde2a in a mouse model of heart failure

Author

Kamel, Rima, primary, Bourcier, Aurélia, additional, Margaria, Jean Piero, additional, Larue, Julie, additional, Varin, Audrey, additional, Ghigo, Alessandra, additional, Hivonnait, Agnès, additional, Mercier-Nomé, Françoise, additional, Mika, Delphine, additional, Algalarrondo, Vincent, additional, Charpentier, Flavien, additional, Hirsch, Emilio, additional, Vandecasteele, Grégoire, additional, Fischmeister, Rodolphe, additional, and Leroy, Jérôme, additional

Published
2022
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15. Modulation of the Bile Acid Enterohepatic Cycle by Intestinal Microbiota Alleviates Alcohol Liver Disease

Author

Ciocan, Dragos, primary, Spatz, Madeleine, additional, Trainel, Nicolas, additional, Hardonnière, Kévin, additional, Domenichini, Séverine, additional, Mercier-Nomé, Françoise, additional, Desmons, Aurore, additional, Humbert, Lydie, additional, Durand, Sylvère, additional, Kroemer, Guido, additional, Lamazière, Antonin, additional, Hugot, Cindy, additional, Perlemuter, Gabriel, additional, and Cassard, Anne-Marie, additional

Published
2022
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16. Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice

Author

Houron, Camille, Ciocan, Dragos, Trainel, Nicolas, Mercier-Nomé, Françoise, Hugot, Cindy, Spatz, Madeleine, Perlemuter, Gabriel, and Cassard, Anne-Marie

Subjects
Male, pectin, Nutrition. Foods and food supply, Adipose Tissue, White, digestive, oral, and skin physiology, NASH, food and beverages, Mice, Obese, fecal microbiota transplantation, Diet, High-Fat, SCFA, digestive system, Article, Gastrointestinal Microbiome, Fatty Liver, Mice, Inbred C57BL, NAFLD, Animals, Pectins, TX341-641, fiber
Abstract

Pectin, a soluble fiber, improves non-alcoholic fatty-liver disease (NAFLD), but its mechanisms are unclear. We aimed to investigate the role of pectin-induced changes in intestinal microbiota (IM) in NAFLD. We recovered the IM from mice fed a high-fat diet, treated or not with pectin, to perform a fecal microbiota transfer (FMT). Mice fed a high-fat diet, which induces NAFLD, were treated with pectin or received a fecal microbiota transfer (FMT) from mice treated with pectin before (preventive FMT) or after (curative FMT) being fed a high-fat diet. Pectin prevented the development of NAFLD, induced browning of adipose tissue, and modified the IM without increasing the abundance of proteobacteria. Preventive FMT also induced browning of white adipose tissue but did not improve liver steatosis, in contrast to curative FMT, which induced an improvement in steatosis. This was associated with an increase in the concentration of short-chain fatty acids (SCFAs), in contrast to preventive FMT, which induced an increase in the concentration of branched SCFAs. Overall, we show that the effect of pectin may be partially mediated by gut bacteria.

Published
2021

19. Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer.

Author

Orcel, Charlotte, Orcel, Charlotte, Vetter, Diana, Durochat, Camille, Chinal, Clarisse, NGuyen, Phuong, Aknin, Marie-Laure, Mercier-Nomé, Françoise, Davy, Martin, Raymond-Letron, Isabelle, Van, Thi-Nhu-Ngoc, Diermeier, Sarah, Godefroy, Anastasia, Gary-Bobo, Magali, Molina, Franck, Balabanian, Karl, Lazennec, Gwendal, Timaxian, Colin, Vogel, Christoph, Orcel, Charlotte, Orcel, Charlotte, Vetter, Diana, Durochat, Camille, Chinal, Clarisse, NGuyen, Phuong, Aknin, Marie-Laure, Mercier-Nomé, Françoise, Davy, Martin, Raymond-Letron, Isabelle, Van, Thi-Nhu-Ngoc, Diermeier, Sarah, Godefroy, Anastasia, Gary-Bobo, Magali, Molina, Franck, Balabanian, Karl, Lazennec, Gwendal, Timaxian, Colin, and Vogel, Christoph

Abstract

Chemokines present in the tumor microenvironment are essential for the control of tumor progression. We show here that several ligands of the chemokine receptor Cxcr2 were up-regulated in the PyMT (polyoma middle T oncogene) model of breast cancer. Interestingly, the knock-down of Cxcr2 in PyMT animals led to an increased growth of the primary tumor and lung metastasis. The analysis of tumor content of PyMT-Cxcr2-/- animals highlighted an increased infiltration of tumor associated neutrophils (TANs), mirrored by a decreased recruitment of tumor associated macrophages (TAMs) compared to PyMT animals. Analysis of PyMT-Cxcr2-/- TANs revealed that they lost their killing ability compared to PyMT-Cxcr2+/+ TANs. The transcriptomic analysis of PyMT-Cxcr2-/- TANs showed that they had a more pronounced pro-tumor TAN2 profile compared to PyMT TANs. In particular, PyMT-Cxcr2-/- TANs displayed an up-regulation of the pathways involved in reactive oxygen species (ROS) production and angiogenesis and factors favoring metastasis, but reduced apoptosis. In summary, our data reveal that a lack of Cxcr2 provides TANs with pro-tumor effects.

Published
2021

20. Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

Author

Wrzosek, Laura, primary, Ciocan, Dragos, additional, Hugot, Cindy, additional, Spatz, Madeleine, additional, Dupeux, Margot, additional, Houron, Camille, additional, Lievin-Le Moal, Vanessa, additional, Puchois, Virginie, additional, Ferrere, Gladys, additional, Trainel, Nicolas, additional, Mercier-Nomé, Françoise, additional, Durand, Sylvere, additional, Kroemer, Guido, additional, Voican, Cosmin Sebastian, additional, Emond, Patrick, additional, Straube, Marjolène, additional, Sokol, Harry, additional, Perlemuter, Gabriel, additional, and Cassard, Anne-Marie, additional

Published
2020
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21. Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury.

Author

Wrzosek, Laura, Ciocan, Dragos, Hugot, Cindy, Spatz, Madeleine, Dupeux, Margot, Houron, Camille, Lievin-Le, Vanessa, Puchois, Virginie, Ferrere, Gladys, Trainel, Nicolas, Mercier-Nomé, Françoise, Durand, Sylvere, Kroemer, Guido, Voican, Cosmin Sebastian, Emond, Patrick, Straube, Marjolène, Sokol, Harry, Perlemuter, Gabriel, and Cassard, Anne-Marie

Subjects
FATTY liver, ARYL hydrocarbon receptors, LACTOBACILLUS rhamnosus, HEPATITIS B, HUMAN microbiota, LIVER injuries, TRYPTOPHAN
Published
2021
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22. The unforeseen intracellular lifestyle of Enterococcus faecalisin hepatocytes

Author

Nunez, Natalia, Derré-Bobillot, Aurélie, Trainel, Nicolas, Lakisic, Goran, Lecomte, Alexandre, Mercier-Nomé, Françoise, Cassard, Anne-Marie, Bierne, Hélène, Serror, Pascale, and Archambaud, Cristel

Abstract

ABSTRACTEnterococcus faecalisis a bacterial species present at a subdominant level in the human gut microbiota. This commensal turns into an opportunistic pathogen under specific conditions involving dysbiosis and host immune deficiency. E. faecalisis one of the rare pathobionts identified to date as contributing to liver damage in alcoholic liver disease. We have previously observed that E. faecalisis internalized in hepatocytes. Here, the survival and fate of E. faecaliswas examined in hepatocytes, the main epithelial cell type in the liver. Although referred to as an extracellular pathogen, we demonstrate that E. faecalisis able to survive and divide in hepatocytes, and form intracellular clusters in two distinct hepatocyte cell lines, in primary mouse hepatocytes, as well as in vivo. This novel process extends to kidney cells. Unraveling the intracellular lifestyle of E. faecalis, our findings contribute to the understanding of pathobiont-driven diseases.

Published
2022
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23. A new hemostatic agent composed of Zn2+-enriched Ca2+alginate activates vascular endothelial cells in vitroand promotes tissue repair invivo

Author

Ponsen, Anne-Charlotte, Proust, Richard, Soave, Sabrina, Mercier-Nomé, Françoise, Garcin, Isabelle, Combettes, Laurent, Lataillade, Jean-Jacques, and Uzan, Georges

Abstract

To control capillary bleeding, surgeons may use absorbable hemostatic agents, such as Surgicel® and TachoSil®. Due to their slow resorption, their persistence in situcan have a negative impact on tissue repair in the resected organ. To avoid complications and obtain a hemostatic agent that promotes tissue repair, a zinc-supplemented calcium alginate compress was developed: HEMO-IONIC®. This compress is non-absorbable and is therefore removed once hemostasis has been achieved. After demonstrating the hemostatic efficacy and stability of the blood clot obtained with HEMO-IONIC, the impact of Surgicel, TachoSil, and HEMO-IONIC on cell activation and tissue repair were compared (i) in vitroon endothelial cells, which are essential to tissue repair, and (ii) in vivoin a mouse skin excision model. In vitro, only HEMO-IONIC maintained the phenotypic and functional properties of endothelial cells and induced their migration. In comparison, Surgicel was found to be highly cytotoxic, and TachoSil inhibited endothelial cell migration. In vivo, only HEMO-IONIC increased angiogenesis, the recruitment of cells essential to tissue repair (macrophages, fibroblasts, and epithelial cells), and accelerated maturation of the extracellular matrix. These results demonstrate that a zinc-supplemented calcium alginate, HEMO-IONIC, applied for 10 min at the end of surgery and then removed has a long-term positive effect on all phases of tissue repair.

Published
2022
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24. Multi-Tissue Characterization of GILZ Expression in Dendritic Cell Subsets at Steady State and in Inflammatory Contexts

Author

Docq, Molène, Vétillard, Mathias, Gallego, Carmen, Jaracz-Ros, Agnieszka, Mercier-Nomé, Françoise, Bachelerie, Françoise, and Schlecht-Louf, Géraldine

Subjects
skin, Tsc22d3/GILZ, QH301-705.5, Mice, Transgenic, Article, Mice, Inbred C57BL, Cell Movement, Organ Specificity, inflammation, Cell Line, Tumor, Langerhans Cells, Neoplasms, Acute Disease, Chronic Disease, Animals, cancer, Lymph Nodes, dendritic cells, Biology (General), Biomarkers, Transcription Factors
Abstract

Dendritic cells (DCs) are key players in the control of tolerance and immunity. Glucocorticoids (GCs) are known to regulate DC function by promoting their tolerogenic differentiation through the induction of inhibitory ligands, cytokines, and enzymes. The GC-induced effects in DCs were shown to critically depend on increased expression of the Glucocorticoid-Induced Leucine Zipper protein (GILZ). GILZ expression levels were further shown to control antigen-presenting cell function, as well as T-cell priming capacity of DCs. However, the pattern of GILZ expression in DC subsets across tissues remains poorly described, as well as the modulation of its expression levels in different pathological settings. To fill in this knowledge gap, we conducted an exhaustive analysis of GILZ relative expression levels in DC subsets from various tissues using multiparametric flow cytometry. This study was performed at steady state, in the context of acute as well as chronic skin inflammation, and in a model of cancer. Our results show the heterogeneity of GILZ expression among DC subsets as well as the complexity of its modulation, that varies in a cell subset- and context-specific manner. Considering the contribution of GILZ in the control of DC functions and its potential as an immune checkpoint in cancer settings, these results are of high relevance for optimal GILZ targeting in therapeutic strategies.

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25. Hydrophobic binary mixtures containing amphotericin B as lipophilic solutions for the treatment of cutaneous leishmaniasis.

Author

Augis, Luc, Nguyễn, Cảnh Hưng, Ciseran, Cécile, Wacha, András, Mercier-Nomé, Françoise, Domenichini, Séverine, Sizun, Christina, Fourmentin, Sophie, and Legrand, François-Xavier

Subjects
*CUTANEOUS leishmaniasis, *AMPHOTERICIN B, *X-ray scattering, *TRANSITION temperature, *CIRCULAR dichroism, *CHOLINE chloride
Abstract

[Display omitted] Cutaneous leishmaniasis, caused by Leishmania parasites, requires treatments with fewer side effects than those currently available. The development of a topical solution based on amphotericin B (AmB) was pursued. The considerable interest in deep eutectic solvents (DESs) and their remarkable advantages inspired the search for a suitable hydrophobic excipient. Various mixtures based on commonly used hydrogen bond donors (HBDs) and acceptors (HBAs) for DES preparations were explored. Initial physical and in-vitro screenings showed the potential of quaternary phosphonium salt-based mixtures. Through thermal analysis, it was determined that most of these mixtures did not exhibit eutectic behavior. X-ray scattering studies revealed a sponge-like nanoscale structure. The most promising formulation, based on a combination of trihexyl(tetradecyl)phosphonium chloride and 1-oleoyl- rac -glycerol, showed no deleterious effects through histological evaluation. AmB was fully solubilized at concentrations between 0.5 and 0.8 mg·mL−1, depending on the formulation. The monomeric state of AmB was observed by circular dichroism. In-vitro irritation tests demonstrated acceptable viability for AmB-based formulations up to 0.5 mg·mL−1. Additionally, an ex-vivo penetration study on pig ear skin revealed no transcutaneous passage, confirming AmB retention in healthy, unaffected skin. [ABSTRACT FROM AUTHOR]

Published
2024
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