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32 results on '"Mercea, Petra A."'

2. 5-ALA Fluorescence Is a Powerful Prognostic Marker during Surgery of Low-Grade Gliomas (WHO Grade II)-Experience at Two Specialized Centers.

Author

Hosmann, Arthur, Millesi, Matthias, Wadiura, Lisa I, Kiesel, Barbara, Mercea, Petra A, Mischkulnig, Mario, Borkovec, Martin, Furtner, Julia, Roetzer, Thomas, Wolfsberger, Stefan, Phillips, Joanna J, Berghoff, Anna S, Hervey-Jumper, Shawn, Berger, Mitchel S, and Widhalm, Georg

Subjects
5-ALA, fluorescence, low-grade gliomas, patient prognosis, Oncology and Carcinogenesis
Abstract

The prediction of the individual prognosis of low-grade glioma (LGG) patients is limited in routine clinical practice. Nowadays, 5-aminolevulinic acid (5-ALA) fluorescence is primarily applied for improved intraoperative visualization of high-grade gliomas. However, visible fluorescence is also observed in rare cases despite LGG histopathology and might be an indicator for aggressive tumor behavior. The aim of this study was thus to investigate the value of intraoperative 5-ALA fluorescence for prognosis in LGG patients. We performed a retrospective analysis of patients with newly diagnosed histopathologically confirmed LGG and preoperative 5-ALA administration at two independent specialized centers. In this cohort, we correlated the visible intraoperative fluorescence status with progression-free survival (PFS), malignant transformation-free survival (MTFS) and overall survival (OS). Altogether, visible fluorescence was detected in 7 (12%) of 59 included patients in focal intratumoral areas. At a mean follow-up time of 5.3 ± 2.9 years, patients with fluorescing LGG had significantly shorter PFS (2.3 ± 0.7 vs. 5.0 ± 0.4 years; p = 0.01), MTFS (3.9 ± 0.7 vs. 8.0 ± 0.6 years; p = 0.03), and OS (5.4 ± 1.0 vs. 10.3 ± 0.5 years; p = 0.01) than non-fluorescing tumors. Our data indicate that visible 5-ALA fluorescence during surgery of pure LGG might be an already intraoperatively available marker of unfavorable patient outcome and thus close imaging follow-up might be considered.

Published
2021

3. Reply to Stummer, W.; Thomas, C. Comment on “Hosmann et al. 5-ALA Fluorescence Is a Powerful Prognostic Marker during Surgery of Low-Grade Gliomas (WHO Grade II)—Experience at Two Specialized Centers. Cancers 2021, 13, 2540”

Author

Hosmann, Arthur, Millesi, Matthias, Wadiura, Lisa I, Kiesel, Barbara, Mercea, Petra A, Mischkulnig, Mario, Borkovec, Martin, Furtner, Julia, Roetzer, Thomas, Wolfsberger, Stefan, Phillips, Joanna J, Berghoff, Anna S, Hervey-Jumper, Shawn, Berger, Mitchel S, and Widhalm, Georg

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Rare Diseases, Cancer, Brain Disorders, Brain Cancer, Oncology and Carcinogenesis, Oncology and carcinogenesis
Abstract

We greatly appreciate Dr. Stummer's and Dr. Thomas's interest in our study and their important comments [...].

Published
2021

5. Open Microsurgical Cerebral Aneurysm Treatment After Failed Endovascular Therapy: An Evaluation of Aneurysm Treatment Frequencies in All Neurovascular Centers Across Austria and the Czech Republic Over 20 Years.

Author

Griessenauer, Christoph J., Dodier, Philippe, Stroh, Nico H., Mercea, Petra A., Bavinzski, Gerhard, Dorfer, Christian, Rössler, Karl, Gruber, Andreas, Gmeiner, Matthias, Thomé, Claudius, Leber, Klaus A., Wolfsberger, Stefan, Baghban, Mustafa, Al-Schameri, Rahman, Kral, Michael, Thakur, Som, Lunzer, Manuel, Popadic, Branko, Sherif, Camillo, and Juráň, Vilém

Published
2024
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13. CD34 microvascularity in low-grade glioma: correlation with 5-aminolevulinic acid fluorescence and patient prognosis in a multicenter study at three specialized centers

Author

Hosmann, Arthur, primary, Jaber, Mohammed, additional, Roetzer-Pejrimovsky, Thomas, additional, Timelthaler, Gerald, additional, Borkovec, Martin, additional, Kiesel, Barbara, additional, Wadiura, Lisa I., additional, Millesi, Matthias, additional, Mercea, Petra A., additional, Phillips, Joanna, additional, Hervey-Jumper, Shawn, additional, Berghoff, Anna S., additional, Hainfellner, Johannes A., additional, Berger, Mitchel S., additional, Stummer, Walter, additional, and Widhalm, Georg, additional

Published
2022
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14. CD34 microvascularity in low-grade glioma: correlation with 5-aminolevulinic acid fluorescence and patient prognosis in a multicenter study at three specialized centers.

Author

Hosmann, Arthur, Jaber, Mohammed, Roetzer-Pejrimovsky, Thomas, Timelthaler, Gerald, Borkovec, Martin, Kiesel, Barbara, Wadiura, Lisa I., Millesi, Matthias, Mercea, Petra A., Phillips, Joanna, Hervey-Jumper, Shawn, Berghoff, Anna S., Hainfellner, Johannes A., Berger, Mitchel S., Stummer, Walter, and Widhalm, Georg

Published
2023
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16. Characterization of ex vivo glioma samples from fluorescence-guided surgery using multimodal optical coherence microscopy-based radiomic features

Author

Gesperger, Johanna, primary, Nenning, Karl-Heinz, additional, Merkle, Conrad W., additional, Lichtenegger, Antonia, additional, Eugui, Pablo, additional, Roetzer, Thomas, additional, Kiesel, Barbara, additional, Mercea, Petra A., additional, Lang, Alexandra, additional, Langs, Georg, additional, Widhalm, Georg, additional, Baumann, Bernhard, additional, and Wöhrer, Adelheid, additional

Published
2022
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17. Androgen Receptor is Expressed in Breast Cancer Brain Metastases

Author

Bergen, Elisabeth S., primary, Berghoff, Anna S., additional, Steindl, Ariane, additional, Rajky, Orsolya, additional, Mercea, Petra A., additional, Kiesel, Barbara, additional, Tendl-Schulz, Kristina, additional, Bago-Horvath, Zsuzsanna, additional, Exner, Ruth, additional, Fitzal, Florian, additional, Dieckmann, Karin, additional, Widhalm, Georg, additional, Steger, Guenther G., additional, Preusser, Matthias, additional, and Bartsch, Rupert, additional

Published
2021
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18. Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning

Author

Gesperger, Johanna, Lichtenegger, Antonia, Roetzer, Thomas, Salas, Matthias, Eugui, Pablo, Harper, Danielle J., Merkle, Conrad W., Augustin, Marco, Kiesel, Barbara, Mercea, Petra A., Widhalm, Georg, Baumann, Bernhard, and Woehrer, Adelheid

Subjects
optical coherence tomography, glioma, metastasis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Article, attenuation
Abstract

Fluorescence-guided surgery is a state-of-the-art approach for intraoperative imaging during neurosurgical removal of tumor tissue. While the visualization of high-grade gliomas is reliable, lower grade glioma often lack visible fluorescence signals. Here, we present a hybrid prototype combining visible light optical coherence microscopy (OCM) and high-resolution fluorescence imaging for assessment of brain tumor samples acquired by 5-aminolevulinic acid (5-ALA) fluorescence-guided surgery. OCM provides high-resolution information of the inherent tissue scattering and absorption properties of tissue. We here explore quantitative attenuation coefficients derived from volumetric OCM intensity data and quantitative high-resolution 5-ALA fluorescence as potential biomarkers for tissue malignancy including otherwise difficult-to-assess low-grade glioma. We validate our findings against the gold standard histology and use attenuation and fluorescence intensity measures to differentiate between tumor core, infiltrative zone and adjacent brain tissue. Using large field-of-view scans acquired by a near-infrared swept-source optical coherence tomography setup, we provide initial assessments of tumor heterogeneity. Finally, we use cross-sectional OCM images to train a convolutional neural network that discriminates tumor from non-tumor tissue with an accuracy of 97%. Collectively, the present hybrid approach offers potential to translate into an in vivo imaging setup for substantially improved intraoperative guidance of brain tumor surgeries.

Published
2020
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19. Multimodal optical coherence microscopy and texture analysis for ex vivo brain tumors from fluorescence-guided surgery

Author

Gesperger, Johanna, primary, Lichtenegger, Antonia, additional, Roetzer, Thomas, additional, Nenning, Karl-Heinz, additional, Eugui, Pablo, additional, Kiesel, Barbara, additional, Merkle, Conrad W., additional, Augustin, Marco, additional, Mercea, Petra A., additional, Widhalm, Georg, additional, Wöhrer, Adelheid, additional, and Baumann, Bernhard, additional

Published
2021
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20. Fluorescence lifetime imaging and spectroscopy for enhanced protoporphyrin IX guided brain tumor surgery

Author

Reichert, David, primary, Erkkilä, Mikael T., additional, Widhalm, Georg, additional, Kiesel, Barbara, additional, Wadiura, Lisa, additional, Mercea, Petra, additional, Andreana, Marco, additional, Unterhuber, Angelika, additional, Wilzbach, Marco, additional, Hauger, Christoph, additional, Drexler, Wolfgang, additional, Leitgeb, Rainer, additional, Rötzer, Thomas, additional, and Wöhrer, Adelheid, additional

Published
2021
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21. Prognostic Value of 5-ALA Fluorescence, Tumor Cell Infiltration and Angiogenesis in the Peritumoral Brain Tissue of Brain Metastases

Author

Mercea, Petra A., primary, Mischkulnig, Mario, additional, Kiesel, Barbara, additional, Wadiura, Lisa I., additional, Roetzer, Thomas, additional, Prihoda, Romana, additional, Heicappell, Patricia, additional, Kreminger, Judith, additional, Furtner, Julia, additional, Woehrer, Adelheid, additional, Preusser, Matthias, additional, Roessler, Karl, additional, Berghoff, Anna S., additional, and Widhalm, Georg, additional

Published
2021
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22. Detailed analysis of 5-aminolevulinic acid induced fluorescence in different brain metastases at two specialized neurosurgical centers: experience in 157 cases

Author

Marhold, Franz, primary, Mercea, Petra A., additional, Scheichel, Florian, additional, Berghoff, Anna S., additional, Heicappell, Patricia, additional, Kiesel, Barbara, additional, Mischkulnig, Mario, additional, Borkovec, Martin, additional, Wolfsberger, Stefan, additional, Woehrer, Adelheid, additional, Preusser, Matthias, additional, Knosp, Engelbert, additional, Ungersboeck, Karl, additional, and Widhalm, Georg, additional

Published
2020
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23. TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent Gliomas

Author

Mischkulnig, Mario, primary, Kiesel, Barbara, additional, Lötsch, Daniela, additional, Roetzer, Thomas, additional, Borkovec, Martin, additional, Wadiura, Lisa I., additional, Mercea, Petra A., additional, Jaklin, Florian J., additional, Hervey-Jumper, Shawn, additional, Roessler, Karl, additional, Berger, Mitchel S., additional, Widhalm, Georg, additional, and Erhart, Friedrich, additional

Published
2020
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24. High Diagnostic Accuracy of Visible 5‐ALA Fluorescence in Meningioma Surgery According to Histopathological Analysis of Tumor Bulk and Peritumoral Tissue

Author

Wadiura, Lisa I., primary, Millesi, Matthias, additional, Makolli, Jessica, additional, Wais, Jonathan, additional, Kiesel, Barbara, additional, Mischkulnig, Mario, additional, Mercea, Petra A., additional, Roetzer, Thomas, additional, Knosp, Engelbert, additional, Rössler, Karl, additional, and Widhalm, Georg, additional

Published
2020
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25. SURG-13. EVALUATION OF 5-ALA FLUORESCENCE IN BRAIN METASTASES OF VARIOUS PRIMARY TUMORS: A MULTICENTER STUDY WITH EXPERIENCE IN 157 CASES

Author

Mercea, Petra Andreea, primary, Marhold, Franz, additional, Scheichel, Florian, additional, Kiesel, Barbara, additional, Mischkulnig, Mario, additional, Berghoff, Anna, additional, Woehrer, Adelheid, additional, Preusser, Matthias, additional, Knosp, Engelbert, additional, Ungersboeck, Karl, additional, and Widhalm, Georg, additional

Published
2019
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32. Detailed analysis of 5-aminolevulinic acid induced fluorescence in different brain metastases at two specialized neurosurgical centers: experience in 157 cases.

Author

Marhold F, Mercea PA, Scheichel F, Berghoff AS, Heicappell P, Kiesel B, Mischkulnig M, Borkovec M, Wolfsberger S, Woehrer A, Preusser M, Knosp E, Ungersboeck K, and Widhalm G

Abstract

Objective: Incomplete neurosurgical resection of brain metastases (BM) due to insufficient intraoperative visualization of tumor tissue is a major clinical challenge and might result in local recurrence. Recently, visible 5-aminolevulinic acid (5-ALA) induced fluorescence was first reported in patients with BM. The aim of this study was thus to investigate, for the first time systematically, the value of 5-ALA fluorescence for intraoperative visualization of BM in a large patient cohort., Methods: Adult patients (≥ 18 years) with resection of suspected BM after preoperative 5-ALA administration were prospectively recruited at two specialized neurosurgical centers. During surgery, the fluorescence status (visible or no fluorescence); fluorescence quality (strong, vague, or none); and fluorescence homogeneity (homogeneous or heterogeneous) of each BM was investigated. Additionally, these specific fluorescence characteristics of BM were correlated with the primary tumor type and the histopathological subtype. Tumor diagnosis was established according to the current WHO 2016 criteria., Results: Altogether, 157 BM were surgically treated in 154 patients. Visible fluorescence was observed in 104 BM (66%), whereas fluorescence was absent in the remaining 53 cases (34%). In detail, 53 tumors (34%) showed strong fluorescence, 51 tumors (32%) showed vague fluorescence, and 53 tumors (34%) had no fluorescence. The majority of BM (84% of cases) demonstrated a heterogeneous fluorescence pattern. According to primary tumor, visible fluorescence was less frequent in BM of melanomas compared to all other tumors (p = 0.037). According to histopathological subtype, visible fluorescence was more common in BM of ductal breast cancer than all other subtypes (p = 0.008). It is of note that visible fluorescence was observed in the surrounding brain tissue after the resection of BM in 74 (67%) of 111 investigated cases as well., Conclusions: In this largest series to date, visible 5-ALA fluorescence was detected in two-thirds of BM. However, the characteristic heterogeneous fluorescence pattern and frequent lack of strong fluorescence limits the use of 5-ALA in BM and thus this technique needs further improvements.

Published
2019
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