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15 results on '"Merbold U"'

1. The microgravity environment of the D1 mission

Author

Hamacher, H, Merbold, U, and Jilg, R

Subjects
Materials Processing
Abstract

Some characteristic features and results of D1 microgravity measurements are discussed as performed in the Material Science Double Rack (MSDR) and the Materials Science Double Rack for Experiment Modules and Apparatus (MEDEA). Starting with a brief review of the main potential disturbances, the payload aspects of interest to the analysis and the accelerometer measuring systems are described. The microgravity data are analyzed with respect to selected mission events such as thruster firings for attitude control, operations of Spacelab experiment facilities, vestibular experiments and crew activities. The origins are divided into orbit, vehicle, and experiment induced perturbations. It has been found that the microgravity-environment is dictated mainly by payload-induced perturbations. To reduce the microgravity-level, the design of some experiment facilities has to be improved by minimizing the number of moving parts, decoupling of disturbing units from experiment facilities, by taking damping measures, etc. In addition, strongly disturbing experiments and very sensitive investigations should be performed in separate mission phases.

Published
1990

4. Vom globalen Dorf zur virtuellen Raumstation

Author

Damian, K., Felger, W., Fröhlich, T., Merbold, U., and Publica

Subjects
Telekommunikation, training, virtuelle Realität, CSCW
Abstract

Mittels virtueller Realitaet koennen Astronauten kuenftig Gruppenarbeit im Weltraum vorab am Boden einueben, auch wenn sie sich physisch an verschiedenen Orten aufhalten.

Published
1996

7. Payload crew members' view of Spacelab operations

Author

Garriott, O. K, Parker, R. A. R, Lichtenberg, B. K, and Merbold, U

Subjects
Astronautics (General)
Abstract

Various operational aspects of the Spacelab 1 mission are reviewed by the four payload crew members. Two-shift operations, voice communication with ground investigators, joint participation in experiment activity, Spacelab performance, and recent advances are discussed.

Published
1984

15. Superior nuclear receptor selectivity and therapeutic index of methylprednisolone aceponate versus mometasone furoate.

Author

Mirshahpanah P, Döcke WD, Merbold U, Asadullah K, Röse L, Schäcke H, and Zollner TM

Subjects
Administration, Topical, Animals, Anti-Inflammatory Agents administration & dosage, Anti-Inflammatory Agents adverse effects, Atrophy chemically induced, Atrophy pathology, Disease Models, Animal, Methylprednisolone administration & dosage, Methylprednisolone adverse effects, Methylprednisolone therapeutic use, Mometasone Furoate, Pregnadienediols administration & dosage, Pregnadienediols adverse effects, Protein Binding drug effects, Protein Binding physiology, Rats, Rats, Mutant Strains, Rats, Nude, Rats, Wistar, Receptors, Androgen drug effects, Receptors, Androgen physiology, Receptors, Cytoplasmic and Nuclear drug effects, Receptors, Mineralocorticoid drug effects, Receptors, Mineralocorticoid physiology, Receptors, Progesterone drug effects, Receptors, Progesterone physiology, Skin blood supply, Skin pathology, Telangiectasis chemically induced, Telangiectasis pathology, Anti-Inflammatory Agents therapeutic use, Methylprednisolone analogs & derivatives, Pregnadienediols therapeutic use, Receptors, Cytoplasmic and Nuclear physiology
Abstract

Although introduced more than 50 years ago, topical glucocorticoids are still the first line therapy for many inflammatory skin disorders such as atopic eczema, contact dermatitis and many others. Recently, significant improvements have been made to optimize the ratio of desired to unwanted effects. While with early compounds such as triamcinolone, topical side effects such as skin atrophy and telangiectasias can be observed rather frequently, newer drugs such as methylprednisolone aceponate or mometasone furoate have a significantly improved therapeutic index. The present study compared these two modern topical glucocorticoids, which possess the highest therapeutic index currently found, in terms of nuclear receptor selectivity in vitro and induction of the most important local side effects (skin atrophy and telangiectasias) in a relevant rodent model in vivo. We demonstrate that methylprednisolone aceponate displays higher specificity in nuclear receptor binding compared with mometasone furoate. Methylprednisolone aceponate was also markedly superior in terms of minimizing induction of skin atrophy or telangiectasias when compared with mometasone furoate. Based on these observations, methylprednisolone aceponate is expected to have a greater therapeutic index as compared with mometasone furoate, at least in the test systems used here. The degree to which this observation may translate into a clinical setting requires confirmation.

Published
2007
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