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1. Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study

Author

Brown, Mark A., Davis, Gregory K., Parker, Claire, Walters, Barry N., Sass, Nelson, Ansermino, J. Mark, Cao, Vivien, Cundiff, Geoffrey W., von Dadelszen, Emma C.M., Douglas, M. Joanne, Dumont, Guy A., Dunsmuir, Dustin T., Hutcheon, Jennifer A., Joseph, K.S., Lalji, Sayrin, Lee, Tang, Li, Jing, Lim, Kenneth I., Lisonkova, Sarka, Lott, Paula, Menzies, Jennifer M., Millman, Alexandra L., Palmer, Lynne, Payne, Beth A., Qu, Ziguang, Russell, James A., Sawchuck, Diane, Shaw, Dorothy, Still, D. Keith, Ukah, U. Vivian, Wagner, Brenda, Walley, Keith R., Hugo, Dany, Gruslin, The late Andrée, Tawagi, George, Smith, Graeme N., Côté, Anne-Marie, Moutquin, Jean-Marie, Ouellet, Annie B., Lee, Shoo K., Duan, Tao, Zhou, Jian, Haniff, The late Farizah, Mahajan, Swati, Noovao, Amanda, Karjalainend, Hanna, Kortelainen, Alja, Laivuori, Hannele, Ganzevoort, J. Wessel, Groen, Henk, Kyle, Phillipa M., Moore, M. Peter, Pullar, Barbra, Bhutta, Zulfiqar A., Qureshi, Rahat N., Sikandar, Rozina, Bhutta, The late Shereen Z., Cloete, Garth, Hall, David R., van Papendorp, The late Erika, Steyn, D. Wilhelm, Biryabarema, Christine, Mirembe, Florence, Nakimuli, Annettee, Allotey, John, Thangaratinam, Shakila, Nicolaides, Kypros H., Ionescu, Olivia, Syngelaki, Argyro, de Swiet, Michael, Magee, Laura A., von Dadelszen, Peter, Akolekar, Ranjit, Walker, James J., Robson, Stephen C., Broughton-Pipkin, Fiona, Loughna, Pamela, Vatish, Manu, Redman, Christopher W.G., Barry, Sarah J.E., Kavanagh, Kimberley, Montgomery-Csobán, Tunde, Murray, Paul, Robertson, Chris, Tsigas, Eleni Z., Woelkers, Douglas A., Lindheimer, Marshall D., Grobman, William A., Sibai, Baha M., Merialdi, Mario, Widmer, Mariana, Montgomery-Csobán, Tünde, Barry, Sarah J E, Vivian Ukah, U, Payne, Beth A, Nicolaides, Kypros H, Hutcheon, Jennifer A, and Magee, Laura A

Published
2024
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4. Application of standardized methods to evaluate the environmental safety of polyvinyl alcohol disposed of down the drain.

Author

McDonough, Kathleen, Hall, Maura J., Wilcox, Ashley, Menzies, Jennifer, Brill, Jessica, Morris, Brian, and Connors, Kristin

Subjects
DISSOLVED organic matter, ENVIRONMENTAL security, SUSTAINABILITY, ACUTE toxicity testing, POLYVINYL alcohol
Abstract

The purpose of this research was to use polyvinyl alcohol (PVOH) 18‐88 as a case study to evaluate the environmental fate, ecotoxicity, and overall safety profile of water‐soluble, nonmodified PVOH polymers used in detergent films. An OECD 303A Wastewater Treatment Plant Simulation Study was conducted with dissolved organic carbon as the analytical endpoint to evaluate the removal of PVOH 18‐88 during wastewater treatment. During the plateau phase, high levels of removal due to biodegradation were observed (average 97.4 ± 7.1, range: 88%–116%). The OECD 303A study quantitatively verified that surface water is the dominant receiving compartment for PVOH 18‐88 post wastewater treatment. Acute algae, invertebrate, and fish embryo (fish embryo acute toxicity test [FET]) ecotoxicity studies quanitified the 50% lethal/effect concentration (L/EC50) for PVOH 18‐88. Due to the potential for the chorion to impact PVOH 18‐88 bioavailability, both chorionated and dechorionated FET tests were conducted. L/EC50 > 1000 mg/L for FET (chorionated and dechorionated), invertebrate, and algae were observed. The Sustainable Futures (US) and REACH (EU) frameworks were used to evaluate environmental risk. For the US assessment, the Exposure and Fate Assessment Screening Tool was used to predict the single day lowest flow over a 10‐year period (1Q10) surface water concentration and the seven consecutive days of lowest flow over a 10‐year period (7Q10) surface water concentration and compared with acute and chronic concentrations of concern. For the EU assessment, the European Union System for the Evaluation of Substances was used to predict local and regional exposure concentrations and compared to the predicted no effect concentration. For both regulatory assessments, the exposure concentrations were >2 orders of magnitude below the effect concentrations. Integr Environ Assess Manag 2024;20:1693–1705. © 2024 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC). Key Points: Polyvinyl alcohol (PVOH) 18‐88 was used as a case study to evaluate the environmental fate, ecotoxicity, and overall safety profile of water‐soluble, nonmodified PVOH polymers used in detergent films.Polyvinyl alcohol 18‐88 was biodegraded extensively during wastewater treatment.Low ecotoxicity was observed with measured LC/EC50s > 1000 mg/L.The US and EU environmental risk assessments predicted exposure concentrations were >2 orders of magnitude below effect concentrations, providing significant assurance of safety for PVOH 18‐88 as a representative test substance for nonmodified PVOH polymers used in detergent films. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study

Author

Montgomery-Csobán, Tünde, primary, Kavanagh, Kimberley, additional, Murray, Paul, additional, Robertson, Chris, additional, Barry, Sarah J E, additional, Vivian Ukah, U, additional, Payne, Beth A, additional, Nicolaides, Kypros H, additional, Syngelaki, Argyro, additional, Ionescu, Olivia, additional, Akolekar, Ranjit, additional, Hutcheon, Jennifer A, additional, Magee, Laura A, additional, von Dadelszen, Peter, additional, Brown, Mark A., additional, Davis, Gregory K., additional, Parker, Claire, additional, Walters, Barry N., additional, Sass, Nelson, additional, Ansermino, J. Mark, additional, Cao, Vivien, additional, Cundiff, Geoffrey W., additional, von Dadelszen, Emma C.M., additional, Douglas, M. Joanne, additional, Dumont, Guy A., additional, Dunsmuir, Dustin T., additional, Hutcheon, Jennifer A., additional, Joseph, K.S., additional, Lalji, Sayrin, additional, Lee, Tang, additional, Li, Jing, additional, Lim, Kenneth I., additional, Lisonkova, Sarka, additional, Lott, Paula, additional, Menzies, Jennifer M., additional, Millman, Alexandra L., additional, Palmer, Lynne, additional, Payne, Beth A., additional, Qu, Ziguang, additional, Russell, James A., additional, Sawchuck, Diane, additional, Shaw, Dorothy, additional, Still, D. Keith, additional, Ukah, U. Vivian, additional, Wagner, Brenda, additional, Walley, Keith R., additional, Hugo, Dany, additional, Gruslin, The late Andrée, additional, Tawagi, George, additional, Smith, Graeme N., additional, Côté, Anne-Marie, additional, Moutquin, Jean-Marie, additional, Ouellet, Annie B., additional, Lee, Shoo K., additional, Duan, Tao, additional, Zhou, Jian, additional, Haniff, The late Farizah, additional, Mahajan, Swati, additional, Noovao, Amanda, additional, Karjalainend, Hanna, additional, Kortelainen, Alja, additional, Laivuori, Hannele, additional, Ganzevoort, J. Wessel, additional, Groen, Henk, additional, Kyle, Phillipa M., additional, Moore, M. Peter, additional, Pullar, Barbra, additional, Bhutta, Zulfiqar A., additional, Qureshi, Rahat N., additional, Sikandar, Rozina, additional, Bhutta, The late Shereen Z., additional, Cloete, Garth, additional, Hall, David R., additional, van Papendorp, The late Erika, additional, Steyn, D. Wilhelm, additional, Biryabarema, Christine, additional, Mirembe, Florence, additional, Nakimuli, Annettee, additional, Allotey, John, additional, Thangaratinam, Shakila, additional, Nicolaides, Kypros H., additional, de Swiet, Michael, additional, Magee, Laura A., additional, Walker, James J., additional, Robson, Stephen C., additional, Broughton-Pipkin, Fiona, additional, Loughna, Pamela, additional, Vatish, Manu, additional, Redman, Christopher W.G., additional, Barry, Sarah J.E., additional, Montgomery-Csobán, Tunde, additional, Tsigas, Eleni Z., additional, Woelkers, Douglas A., additional, Lindheimer, Marshall D., additional, Grobman, William A., additional, Sibai, Baha M., additional, Merialdi, Mario, additional, and Widmer, Mariana, additional

Published
2024
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6. Caretaker conventions in Australasia: minding the shop for government

Author

Tiernan, Anne and Menzies, Jennifer

Subjects
public administration, politics and government, australia, decision making, new zealand, Cameron–Clegg coalition, Chief executive officer, Civil service, Prime minister, Queensland, bic Book Industry Communication::J Society & social sciences::JP Politics & government
Abstract

In this monograph, Anne Tiernan and Jennifer Menzies capably chart the often hazardous terrain of the ‘caretaker period’ that ensues from the time an election is called until a new government is formed. This is a landscape fraught with political and administrative dangers – particularly for public servants who are required to ‘mind the shop’ and keep the basic machinery of government going. The conventions represent an historical accretion of custom, practice and rules, often leavened with uncertainty. In tackling their subject, Tiernan and Menzies draw upon their shared past experiences as public servants and ministerial ‘staffers’ as well as the highest standards of academic scholarship – this is a ‘must read’ for politicians, public servants and students of government.

Published
2007
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10. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model

Author

von Dadelszen, Peter, Payne, Beth, Li, Jing, Ansermino, J Mark, Pipkin, Fiona Broughton, Côté, Anne-Marie, Douglas, M Joanne, Gruslin, Andrée, Hutcheon, Jennifer A, Joseph, KS, Kyle, Phillipa M, Lee, Tang, Loughna, Pamela, Menzies, Jennifer M, Merialdi, Mario, Millman, Alexandra L, Moore, M Peter, Moutquin, Jean-Marie, Ouellet, Annie B, Smith, Graeme N, Walker, James J, Walley, Keith R, Walters, Barry N, Widmer, Mariana, Lee, Shoo K, Russell, James A, and Magee, Laura A

Published
2011
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11. The CHIPS Randomized Controlled Trial (Control of Hypertension in Pregnancy Study): Is Severe Hypertension Just an Elevated Blood Pressure?

Author

Magee, Laura A., von Dadelszen, Peter, Singer, Joel, Lee, Terry, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, Johanna, Gafni, Amiram, Helewa, Michael, Hutton, Eileen, Koren, Gideon, Lee, Shoo K., Logan, Alexander G., Ganzevoort, Wessel, Welch, Ross, Thornton, Jim G., and Moutquin, Jean-Marie

Published
2016
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12. Caretaker conventions in Australasia : Minding the shop for government

Author

Menzies, Jennifer and Tiernan, Anne

Subjects
Political Science
Abstract

In this monograph, Anne Tiernan and Jennifer Menzies capably chart the often hazardous terrain of the ‘caretaker period’ that ensues from the time an election is called until a new government is formed. This is a landscape fraught with political and administrative dangers – particularly for public servants who are required to ‘mind the shop’ and keep the basic machinery of government going. The conventions represent an historical accretion of custom, practice and rules, often leavened with uncertainty. In tackling their subject, Tiernan and Menzies draw upon their shared past experiences as public servants and ministerial ‘staffers’ as well as the highest standards of academic scholarship – this is a ‘must read’ for politicians, public servants and students of government.

Published
2007

13. Less-tight versus tight control of hypertension in pregnancy

Author

Magee, Laura A, Dadelszen, Peter von, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E, Menzies, Jennifer, Sanchez, Johanna, Singer, Joel, Gafni, Amiram, Gruslin, Andrée, Helewa, Michael, Hutton, Eileen, Lee, Shoo K, Lee, Terry, Logan, Alexander G, Ganzevoort, Wessel, Welch, Ross, Thornton, Jim G, and Moutquin, Jean-Marie

Published
2015

14. Less-Tight versus Tight Control of Hypertension in Pregnancy

Author

Magee, Laura A., von Dadelszen, Peter, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, Johanna, Singer, Joel, Gafni, Amiram, Gruslin, Andrée, Helewa, Michael, Hutton, Eileen, Lee, Shoo K., Lee, Terry, Logan, Alexander G., Ganzevoort, Wessel, Welch, Ross, Thornton, Jim G., and Moutquin, Jean-Marie

Published
2015
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18. The Taphonomy of Human and Non-Human Skeletal Remains in Australian Conditions and the Implications for Post-Mortem Interval Research

Author

Menzies, Jennifer

Subjects
Decomposition, Postmortem interval, Taphonomy, Forensic anthropology, Time-since-death, Skeletonization
Abstract

Estimating the post-mortem interval (PMI) for surface-deposited skeletal remains is a vital component of forensic investigation in order to eliminate cases of non-forensic interest and to assist with identification of a victim. The aim of this thesis is twofold: to examine the relationship between visible changes to skeletal remains and post-mortem interval in an Australian setting and to investigate the validity of using non-human bones as proxies for human bones in such studies. Estimation of the PMI for human skeletal remains is highly problematic and no standardized method has yet been developed. As a rule, past researchers have investigated single factor methods of PMI determination using either human or non-human remains. Despite small gains, researchers’ efforts are derailed by the complex interaction between environmental factors and the remains and the short time periods over which the studies are done. A longitudinal field study was conducted. At a University of Sydney site (Mandemar), south of Sydney, both fleshed and defleshed bones of human, pig and kangaroo limbs placed on the ground surface were examined and compared over a period of six years. The study focused on recording weight loss, bleaching and weathering (cracking, flaking, surface degradation, exposure of trabecular bone) as well as the interaction of environmental factors such as insects, mould and algae. In addition, a comparison of weathering processes during decomposition was made between the disarticulated human elements from the site above and an intact human cadaver placed out for the purposes of this study at the Australian Facility for Taphonomic Experimental Research (AFTER) in western Sydney, NSW. Factors which showed a relationship with PMI were weight loss, the rate of bleaching of exposed bone surfaces over time, the appearance and/or disappearance of moulds and algae, presence of a carrion beetle and a spike in the onset of weathering processes. Such relationships were however different for human and non-human bones. There were pronounced differences between species with human elements losing considerably more weight over time than the pig or kangaroo. This finding supports published opinions by other researchers that the use of animal substitutes in forensic research may not be valid and should be viewed with caution. The decomposition rate of the cadaver at AFTER was considerably slower than the fleshed, disarticulated elements at Mandemar with bleaching, weathering and growth of algae impeded by mummified tissue, occurring at later stages and not as extensive. This may be attributable to the time of year of placement as the cadaver was initially subjected to cooler winter temperatures. This research should add substantially toward understanding time dependent decomposition processes as they occur over several years in an outdoor Australian setting. This research makes a meaningful contribution to the debate regarding the use of animal proxies in forensic taphonomic research. In addition, the results highlight potentially rewarding avenues of investigation facilitating more focused and specific approaches for future studies.

Published
2021

19. Spatial modeling framework for aquatic exposure assessments of chemicals disposed down the drain: Case studies for China and Japan.

Author

McDonough, Kathleen, Csiszar, Susan A., Fan, Ming, Kapo, Katherine, Menzies, Jennifer, and Vamshi, Raghu

Subjects
SEWAGE purification, STREAMFLOW, ROUTING algorithms, WASTEWATER treatment, ITRACONAZOLE
Abstract

A modeling framework was created for the development of spatially explicit aquatic exposure models for any region or country of interest for chemicals disposed of down the drain. The framework relies on globally available data sets for river flow and population, and locally available data sets for wastewater treatment infrastructure and domestic water use, and leverages the iSTREEM® chemical routing algorithm. The framework was applied to China and Japan as case study countries. Spatially explicit population data were obtained from WorldPop. River flows covering the spatial extent of the two countries were derived from a high‐resolution surface runoff gridded data set that was based on the Curve Number approach and combined with the hydrology network for catchments and rivers from HydroBASINS and HydroSHEDS data sets. Publicly available data from government sources were used for estimating per capita water use and wastewater treatment infrastructure. To demonstrate the framework, the China model was used to predict the levels of the antifungal agent climbazole in rivers across the country, and the Japan model was used to predict river concentrations of linear alkylbenzene sulfonate. For both chemicals, the comparison of measured to modeled values showed good agreement, using linear regression analysis (R2 ≥ 0.96). The framework presented in this study provides a systematic and robust approach to develop spatially resolved exposure models that can be extrapolated to any country or region, allowing more accurate risk assessment of chemicals disposed down the drain by leveraging concentration distributions generated by the model. Integr Environ Assess Manag 2022;18:722–733. © 2021 SETAC Key Points: Modeling framework created for the development of spatially explicit aquatic exposure models for any region or country of interest for chemicals disposed of down the drain.Framework relies on the use of a high‐resolution global flow dataset developed as part of this research.Framework also relies on globally available datasets for population and locally available datasets for wastewater treatment infrastructure and domestic water use.Model framework was successfully applied to two case study countries, China and Japan, which differ significantly in population density, river flow (due to climate and geography), and wastewater treatment infrastructure. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Influence of Gestational Age at Initiation of Antihypertensive Therapy

Author

Pels, Anouk, primary, Mol, Ben Willem J., additional, Singer, Joel, additional, Lee, Terry, additional, von Dadelszen, Peter, additional, Ganzevoort, Wessel, additional, Asztalos, Elizabeth, additional, Magee, Laura A., additional, Gafni, Amiram, additional, Gruslin, Andrée, additional, Helewa, Michael, additional, Hutton, Eileen, additional, Lee, Shoo, additional, Logan, Alexander, additional, Menzies, Jennifer, additional, Moutquin, Jean-Marie, additional, Murphy, Kellie, additional, Rey, Evelyne, additional, Ross, Sue, additional, Sanchez, Johanna, additional, Thornton, Jim G., additional, Welch, Ross, additional, Hoac, Trinh, additional, Kirton, Joanne, additional, Trigiani, Katherine, additional, Zahid, Ainy, additional, Bracken, Michael B., additional, Crowley, Patricia, additional, Duley, Lelia, additional, Ehrenkranz, Richard, additional, Thorpe, Kevin, additional, Chan, Sunny, additional, Shi, Michael, additional, Yu, Shelley, additional, de Lourdes Martin, Raquel, additional, Bassi, Maria Florencia, additional, Caruso, Mirta Clara, additional, Lagunas, Valeria, additional, Vera, Fernando, additional, Mohedano de Duhalde, Maria, additional, Roque, Alicia Beatriz, additional, Roldan, Patricia, additional, Duhalde, Esteban Marcos, additional, Dip, Viviana, additional, Aguirre, Jesus Daniel, additional, Morales, Elba Mirta Alicia, additional, Abreo, Griselda Itati, additional, De Sagastizabal, Teresa, additional, Gomez, Carolina, additional, Rizzi, Nadia, additional, Arias, Carlos, additional, Bruno, Ricardo Antonio, additional, Mahomed, Kassam, additional, Drew, Alison, additional, Green, Ann, additional, Hoare, Jane, additional, Hague, Bill, additional, Coat, Suzette, additional, Crowther, Caroline, additional, Muller, Peter, additional, Trenowden, Sophie, additional, Walters, Barry, additional, Parker, Claire, additional, Graham, Dorothy, additional, Pennell, Craig, additional, Sung, Eileen, additional, Makris, Angela, additional, Lee, Gaksoo, additional, Thornton, Charlene, additional, Hennessy, Annemarie, additional, Farrell, Louise, additional, Sass, Nelson, additional, Korkes, Henri, additional, Ferreira, Dayana Couto, additional, Moreira de Sa, Renato Augusto, additional, Abreu, Monique Schmidt Marques, additional, Bornia, Rita Guerios, additional, da Silva, Nancy Ribeiro, additional, Cardoso, Fernanda Freitas Oliveira, additional, Marques, Caio Coelho, additional, Hornos, Jorge, additional, Davdt, Ricardo Leal, additional, Paula, Letícia Germany, additional, Zanella, Pedro Luis, additional, Inglis, Gabrielle, additional, Dillon, Ruth, additional, Docherty, Ashley, additional, Hutfield, Anna, additional, Still, Keith, additional, Lalji, Sayrin, additional, Van Tent, Tamara, additional, Hotz, Chris, additional, Messmer, Tracy, additional, Ray, Joel G., additional, Berger, Howard, additional, De Souza, Leanne, additional, Lausman, Andrea, additional, Freire-Lizama, Tatiana, additional, Besel, Kate, additional, Gibson, Paul, additional, Ellsworth, Greta, additional, Miller, Leslie, additional, Hawkins, T. Lee-Ann, additional, Hladunewich, Michelle, additional, Rogowsky, Anna, additional, Hui, Dini, additional, Collins, Virginia, additional, Delisle, Isabelle, additional, Fanning, Cora, additional, Demianczuk, Nestor, additional, Khurana, Rshmi, additional, Sia, Winnie, additional, Marnoch, Catherine, additional, Young, Carmen, additional, Lux, Cheryl, additional, Perreault, Sophie, additional, Tremblay, Valerie, additional, Desindes, Sophie, additional, Côté, Anne-Marie, additional, Dagenais, Veronique, additional, Clark, Heather, additional, O’Shea, Elaine, additional, White, Ruth Rennicks, additional, Gandhi, Shital, additional, Martin, Mary-Jean, additional, Brush, Cheryl, additional, Seaward, Gareth, additional, Newstead-Angel, Jill, additional, Brandt, Judy, additional, Martel, Jocelyne, additional, Mytopher, Kristine, additional, Buschau, Elise, additional, Keely, Erin, additional, Waddell, Patti, additional, Shachkina, Svetlana, additional, Karovitch, Alan, additional, Anderson, Robert, additional, Koenig, Nicole, additional, Yong, Theresa, additional, Vasiliou, Marie, additional, Johnson, Peri, additional, Allan, Beth, additional, Natale, Renato, additional, Kennedy, Laura, additional, Opatrny, Lucie, additional, Lavigne, Lorraine, additional, Carson, George, additional, Kelly, Sheila, additional, Crane, Joan, additional, Hutchens, Donna, additional, Kusanovic, Juan Pedro, additional, Figueroa, Christian, additional, Neculman, Karla Silva, additional, Ortiz, Juan Andres, additional, Vargas, Paula, additional, Ferrand, Pedro, additional, Carrillo, Jorge, additional, Borrero, Rodrigo Cifuentes, additional, Gallo, Dahiana Marcela, additional, Moreno, Luisa Fernanda, additional, Kirss, Fred, additional, Rull, Kristiina, additional, Kirss, Anne, additional, Major, Tamas, additional, Fodor, Andrea, additional, Bartha, Tunde, additional, Hallak, Mordechai, additional, Aslih, Nardin, additional, Anabousi-Murra, Saja, additional, Pri-Or, Ester, additional, Harel, Linda, additional, Siev, Sima, additional, Hakim, Marwan, additional, Khoury, Christina Simona, additional, Hamati, Najla, additional, El-Zibdeh, Mazen, additional, Yousef, Lama, additional, Hughes, Ruth, additional, Leishman, Di, additional, Pullar, Barbra, additional, Farrant, Matthew, additional, Swiatkowska-Freund, Malgorzata, additional, Preis, Krzysztof, additional, Traczyk-Los, Anette Aleksandra, additional, Partyka, Anna, additional, Preis-Orlikowska, Joanna, additional, Lukaszuk, Mariusz, additional, Krasomski, Grzegorz, additional, Krekora, Michael, additional, Kedzierska-Markowicz, Anna, additional, Zych-Krekora, Katarzyna, additional, Breborowicz, Grzegorz H., additional, Dera-Szymanowska, Anna, additional, Bakker, Jannet, additional, Akkermans, Joost, additional, van den Akker, Eline, additional, Logtenberg, Sabine, additional, Koenen, Steven, additional, de Reus, Maartje, additional, Borman, David, additional, Oudijk, Martijn A., additional, Bolte, Annemiek, additional, Verfaille, Viki, additional, Graaf, Bart, additional, Porath, Martina, additional, Verhoeven, Corine, additional, Franssen, Maureen T.M., additional, Ulkeman, Lida, additional, Hamming, Ineke, additional, Keurentjes, Jose H.M., additional, van der Wal, Ina, additional, Bijvank, S.W.A. Nij, additional, Lutjes, A.A., additional, Visser, Henricus, additional, Scheepers, Hubertina Catharina Johanna, additional, van Beek, Erik, additional, van Dam, Coby, additional, van den Berg-Swart, Kathy, additional, Pernet, Paula, additional, van der Goes, Birgit, additional, Schuitemaker, Nico, additional, Kleiverda, Gunilla, additional, van Alphen, Marcel, additional, Rosman, Ageeth, additional, Gaugler-Senden, Ingrid, additional, Linders, Marieke, additional, Nelson-Piercy, Catherine, additional, Briley, Annette, additional, Soh, May Ching, additional, Harding, Kate, additional, Tarft, Hayley, additional, Churchill, David, additional, Cheshire, Katherine, additional, Icke, Julia, additional, Ghosh, Mausumi, additional, Thornton, James, additional, Toomassi, Yvonne, additional, Barker, Karen, additional, Fisher, Joanne, additional, Grace, Nicky, additional, Green, Amanda, additional, Gower, Joanne, additional, Molnar, Anna, additional, Parameshwaran, Shobhana, additional, Simm, Andrew, additional, Bugg, George, additional, Davis, Yvette, additional, Desphande, Ruta, additional, Gunn, Yvette, additional, Houda, Mohammed, additional, Jones, Nia, additional, Waugh, Jason, additional, Allan, Carly, additional, Waring, Gareth, additional, Walkinshaw, Steve A., additional, Pascall, Angela, additional, Clement-Jones, Mark, additional, Dower, Michelle, additional, Houghton, Gillian, additional, Longworth, Heather, additional, Purewal, Tej, additional, Tuffnell, Derek, additional, Farrar, Diane, additional, Syson, Jennifer, additional, Butterfield, Gillian, additional, Jones, Vicky, additional, Palethorpe, Rebecca, additional, Germaine, Tracey, additional, Habiba, Marwan, additional, Lee, Debbie, additional, Eniola, Olufemi, additional, Blake, Lynne, additional, Khan, Jane, additional, Cameron, Helen M., additional, Hinshaw, Kim, additional, Bargh, Amanda, additional, Walton, Eileen, additional, Sorinola, Olanrewaju, additional, Guy, Anna, additional, D’Souza, Zoe, additional, Gabriel, Rhiannon, additional, Williams, Jo, additional, Hollands, Heidi, additional, Jibodu, Olujimi, additional, Collier, Sara, additional, Tottie, Pauline, additional, Oxby, Claire, additional, Dwyer, James, additional, Majoko, Franz, additional, Goldring, Helen, additional, Jones, Sharon, additional, Cresswell, Janet, additional, Underwood, Louise, additional, Kelly-Baxter, Mary, additional, Robinson, Rebecca, additional, Anumba, Dilly, additional, Chamberlain, Anne, additional, Pye, Clare, additional, Tower, Clare, additional, Woods, Sue, additional, Horrocks, Lisa, additional, Prichard, Fiona, additional, Moorhead, Lynsey, additional, Lee, Sarah, additional, Stephens, Louise, additional, Taylor, Cara, additional, Thomas, Suzanne, additional, Whitworth, Melissa, additional, Myers, Jenny, additional, Knox, Ellen, additional, Freitas, Katie, additional, Kilby, Mark, additional, Cotterill, Amanda, additional, Abdo, Khalil, additional, Rigby, Katrina, additional, Butler, Julie, additional, Crosfill, Fiona, additional, Hughes, Sean, additional, Prashar, Sanjeev, additional, Soydemir, Fatimah, additional, Ashworth, Janet, additional, Mycock, Lorraine, additional, Smith, Jill, additional, Ikomi, Amaju, additional, Goodsell, Kerry, additional, Byrne, Jean, additional, Masuku, Maxwell, additional, Pilcher, Alice, additional, Khandelwal, Meena, additional, Simpkins, Gunda, additional, Iavicoli, Michelle, additional, Kim, Yon Sook, additional, Fischer, Richard, additional, Perry, Robin, additional, Chang, Eugene Y., additional, Saunders, Tamara D., additional, Oswald, Betty W., additional, Zaks, Kristin D., additional, Rana, Sarosh, additional, McCullough, Dawn, additional, Sfakianaki, Anna, additional, Danton, Cheryl, additional, Kustan, Erin, additional, Coraluzzi, Luisa, additional, How, Helen, additional, Waldon, Christina, additional, Livingston, Jeffrey, additional, Jackson, Sherry, additional, Greene, Lisa, additional, Shah, Dinesh, additional, Tolosa, Jorge E., additional, Rincon, Monica, additional, Pereira, Leonardo, additional, Lawrence, Amy E., additional, Snyder, Janice E., additional, Armstrong, D. Michael, additional, Blue, Teresa, additional, Hester, Austin, additional, and Salisbury, Kathryn, additional

Published
2018
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27. Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study)

Author

Vidler, Marianne, Magee, Laura A., von Dadelszen, Peter, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, Johanna, Singer, Joel, Gafni, Amiram, Helewa, Michael, Hutton, Eileen, Lee, Shoo K., Lee, Terry, Logan, Alexander G., Ganzevoort, Wessel, Welch, Ross, Thornton, Jim, and Moutquin, Jean-Marie

Abstract

Objective: To compare women’s views about blood pressure (BP) control in CHIPS (Control ofHypertension In Pregnancy Study) (NCT01192412).Design: Quantitative and qualitative analysis of questionnaire responses.Setting: International randomised trial (94 sites, 15 countries).Population/sample: 911 (92.9%) women randomised to ‘tight’ (target diastolic blood pressure, 85 mmHg) or ‘less tight’ (target diastolic blood pressure, 100 mmHg) who completed questionnaires.Methods: A questionnaire was administered at ~6–12 weeks postpartum regarding post-discharge morbidity and views about trial participation. Questionnaires were administered by the site co-ordinator, and contact was made by phone, home or clinic visit; rarely, data was collected from medical records. Quantitative analyses were Chi-square or Fisher’s exact test for categorical variables, mixed effects multinomial logistic regression to adjust for confounders, and p

Published
2016

28. The cost implications of less tight versus tight Control of Hypertension in Pregnancy (CHIPS Trial)novelty and significance

Author

Ahmed, Rashid J., Gafni, Amiram, Hutton, Eileen K., Hu, Zheng Jing, Pullenayegum, Eleanor, von Dadelszen, Peter, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, J. Johanna, Ganzevoort, Wessel, Helewa, Michael, Lee, Shoo K., Lee, Terry, Logan, Alexander G., Moutquin, Jean-Marie, Singer, Joel, Thornton, Jim, Welch, Ross, and Magee, Laura A.

Subjects
hypertension, cost analysis, randomized controlled trials, Blood pressure, health policy, pregnancy
Abstract

The CHIPS randomized controlled trial (Control of Hypertension in Pregnancy Study) found no difference in the primary perinatal or secondary maternal outcomes between planned “less tight” (target diastolic 100 mm Hg) and “tight” (target diastolic 85 mm Hg) blood pressure management strategies among women with chronic or gestational hypertension. This study examined which of these management strategies is more or less costly from a third-party payer perspective. A total of 981 women with singleton pregnancies and nonsevere, nonproteinuric chronic or gestational hypertension were randomized at 14 to 33 weeks to less tight or tight control. Resources used were collected from 94 centers in 15 countries and costed as if the trial took place in each of 3 Canadian provinces as a cost-sensitivity analysis. Eleven hospital ward and 24 health service costs were obtained from a similar trial and provincial government health insurance schedules of medical benefits. The mean total cost per woman–infant dyad was higher in less tight versus tight control, but the difference in mean total cost (DM) was not statistically significant in any province: Ontario ($30191.62 versus $24469.06; DM $5723, 95% confidence interval, −$296 to $12272; P=0.0725); British Columbia ($30593.69 versus $24776.51; DM $5817; 95% confidence interval, −$385 to $12349; P=0.0725); or Alberta ($31510.72 versus $25510.49; DM $6000.23; 95% confidence interval, −$154 to $12781; P=0.0637). Tight control may benefit women without increasing risk to neonates (as shown in the main CHIPS trial), without additional (and possibly lower) cost to the healthcare system.

Published
2016

32. Can adverse maternal and perinatal outcomes be predicted when blood pressure becomes elevated? Secondary analyses from the CHIPS (Control of Hypertension In Pregnancy Study) randomized controlled trial

Author

Magee, Laura A., primary, Dadelszen, Peter, additional, Singer, Joel, additional, Lee, Terry, additional, Rey, Evelyne, additional, Ross, Susan, additional, Asztalos, Elizabeth, additional, Murphy, Kellie E., additional, Menzies, Jennifer, additional, Sanchez, Johanna, additional, Gafni, Amiram, additional, Gruslin, Andrée, additional, Helewa, Michael, additional, Hutton, Eileen, additional, Lee, Shoo K., additional, Logan, Alexander G., additional, Ganzevoort, Wessel, additional, Welch, Ross, additional, Thornton, Jim G., additional, and Moutquin, Jean Marie, additional

Published
2016
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33. Influence of Gestational Age at Initiation of Antihypertensive Therapy: Secondary Analysis of CHIPS Trial Data (Control of Hypertension in Pregnancy Study).

Author

Gafni, Amiram, Gruslin, Andrée, Helewa, Michael, Hutton, Eileen, Lee, Shoo, Logan, Alexander, Menzies, Jennifer, Moutquin, Jean-Marie, Murphy, Kellie, Rey, Evelyne, Ross, Sue, Sanchez, Johanna, Thornton, Jim G., Welch, Ross, Hoac, Trinh, Kirton, Joanne, Trigiani, Katherine, Zahid, Ainy, Bracken, Michael B., and Crowley, Patricia

Abstract

For hypertensive women in CHIPS (Control of Hypertension in Pregnancy Study), we assessed whether the maternal benefits of tight control could be achieved, while minimizing any potentially negative effect on fetal growth, by delaying initiation of antihypertensive therapy until later in pregnancy. For the 981 women with nonsevere, chronic or gestational hypertension randomized to less-tight (target diastolic blood pressure, 100 mm Hg), or tight (target, 85 mm Hg) control, we used mixed-effects logistic regression to examine whether the effect of less-tight (versus tight) control on major outcomes was dependent on gestational age at randomization, adjusting for baseline factors as in the primary analysis and including an interaction term between gestational age at randomization and treatment allocation. Gestational age was considered categorically (quartiles) and continuously (linear or quadratic form), and the optimal functional form selected to provide the best fit to the data based on the Akaike information criterion. Randomization before (but not after) 24 weeks to less-tight (versus tight) control was associated with fewer babies with birth weight <10th centile (Pinteraction=0.005), but more preterm birth (Pinteraction=0.043), and no effect on perinatal death or high-level neonatal care >48 hours (Pinteraction=0.354). For the mother, less-tight (versus tight) control was associated with more severe hypertension at all gestational ages but particularly so before 28 weeks (Pinteraction=0.076). In women with nonsevere, chronic, or gestational hypertension, there seems to be no gestational age at which less-tight (versus tight) control is the preferred management strategy to optimize maternal or perinatal outcomes.Clinical Trial Registration: URL: https://www.isrctn.com. Unique identifier: ISRCTN71416914. [ABSTRACT FROM AUTHOR]

Published
2018
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35. Less-Tight Versus Tight Control of Hypertension in Pregnancy

Author

Magee, Laura A., primary, von Dadelszen, Peter, additional, Rey, Evelyne, additional, Ross, Susan, additional, Asztalos, Elizabeth, additional, Murphy, Kellie E., additional, Menzies, Jennifer, additional, Sanchez, Johanna, additional, Singer, Joel, additional, Gafni, Amiram, additional, Gruslin, Andrée, additional, Helewa, Michael, additional, Hutton, Eileen, additional, Lee, Shoo K., additional, Lee, Terry, additional, Logan, Alexander G., additional, Ganzevoort, Wessel, additional, Welch, Ross, additional, Thornton, Jim G., additional, and Moutquin, Jean-Marie, additional

Published
2015
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36. [59-OR]

Author

Magee, Laura A., primary, Dadelszen, Peter von, additional, Rey, Evelyne, additional, Ross, Susan, additional, Asztalos, Elizabeth, additional, Murphy, Kellie E., additional, Menzies, Jennifer, additional, Sanchez, Johanna, additional, Singer, Joel, additional, Gafni, Amiram, additional, Gruslin, Andree, additional, Helewa, Michael, additional, Hutton, Eileen, additional, Lee, Shoo K., additional, Logan, Alexander G., additional, Ganzevoort, Wessel, additional, Welch, Ross, additional, Thornton, Jim G., additional, and Moutquin, Jean-Marie, additional

Published
2015
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37. The PIERS (Pre-eclampsia Integrated Estimate of RiSk) model : development of a valid outcome prediction model for pre-eclampsia

Author

Menzies, Jennifer Marie

Abstract

Objective: This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model – that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to seven days after, admission with pre-eclampsia (study eligibility). Methods: Prospective data for this project came from the PIERS study database (1259 women, seven international tertiary centers, 4 year period). Part 1. Using PIERS data and retrospective data from BC Women’s Hospital, the impact of standardized assessment and surveillance (standing orders) on the incidence of adverse maternal outcomes was assessed. Part 2. Criteria of ‘severe’ disease were assessed against their ability to identify maternal risk. Part 3. For PIERS model development and initial validation, independent predictor variables were selected through univariable logistic regression and tests of correlation and co-linearity. The fitted models were derived using multivariate logistic regression, predictive performance evaluated using area under the receiver-operator curve [AUC], and initial validation by cross-validation. Results: Part 1. Introducing standing orders reduced the incidence of adverse maternal outcomes (5.1% to 0.7%; OR 0.14 [0.04, 0.49]). Part 2. Most Canadian and American severity criteria did not predict adverse outcomes. Part 3. Two PIERS outcome prediction models were developed and initially validated. The fullPIERS model (AUC 0.906 [0.851, 0.961]), for use in well-resourced settings, comprises six independent clinical and laboratory variables. The miniPIERS model (AUC 0.817 [0.738, 0.896]), for use in minimally-resourced settings, comprises three independent clinical variables. Both models (fitted and cross-validated) maintain AUC>0.7 up to seven days after eligibility. Conclusion: Standardized assessment and surveillance of women with pre-eclampsia reduces maternal risks. Published criteria of ‘severe’ disease do not denote increased maternal risk. The two pre-eclampsia-specific outcome prediction models, fullPIERS and miniPIERS, identify maternal risk up to 7 days before complications arise.

Published
2009
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39. The Cost Implications of Less Tight Versus Tight Control of Hypertension in Pregnancy (CHIPS Trial).

Author

Ahmed, Rashid J., Hutton, Eileen K., Murphy, Kellie E., Logan, Alexander G., Menzies, Jennifer, Sanchez, J. Johanna, Ganzevoort, Wessel, Helewa, Michael, Lee, Shoo K., Lee, Terry, Moutquin, Jean-Marie, Singer, Joel, Gafni, Amiram, Thornton, Jim G., Welch, Ross, Magee, Laura A., von Dadelszen, Peter, Zheng Jing Hu, Pullenayegum, Eleanor, and Rey, Evelyne

Abstract

Unlabelled: The CHIPS randomized controlled trial (Control of Hypertension in Pregnancy Study) found no difference in the primary perinatal or secondary maternal outcomes between planned "less tight" (target diastolic 100 mm Hg) and "tight" (target diastolic 85 mm Hg) blood pressure management strategies among women with chronic or gestational hypertension. This study examined which of these management strategies is more or less costly from a third-party payer perspective. A total of 981 women with singleton pregnancies and nonsevere, nonproteinuric chronic or gestational hypertension were randomized at 14 to 33 weeks to less tight or tight control. Resources used were collected from 94 centers in 15 countries and costed as if the trial took place in each of 3 Canadian provinces as a cost-sensitivity analysis. Eleven hospital ward and 24 health service costs were obtained from a similar trial and provincial government health insurance schedules of medical benefits. The mean total cost per woman-infant dyad was higher in less tight versus tight control, but the difference in mean total cost (DM) was not statistically significant in any province: Ontario ($30 191.62 versus $24 469.06; DM $5723, 95% confidence interval, -$296 to $12 272; P=0.0725); British Columbia ($30 593.69 versus $24 776.51; DM $5817; 95% confidence interval, -$385 to $12 349; P=0.0725); or Alberta ($31 510.72 versus $25 510.49; DM $6000.23; 95% confidence interval, -$154 to $12 781; P=0.0637). Tight control may benefit women without increasing risk to neonates (as shown in the main CHIPS trial), without additional (and possibly lower) cost to the healthcare system.Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01192412. [ABSTRACT FROM AUTHOR]

Published
2016
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40. With the COVID crisis easing, is the National Cabinet still fit for purpose?

Author

Deem, Jacob and Menzies, Jennifer

Subjects
COVID-19 pandemic, POLITICIANS, STATE governments, ADMINISTRATIVE remedies, FEDERAL government
Abstract

Since the abolition of the Council of Australian Governments(COAG) in 2020, National Cabinet has served as the primary forumfor Australia's leaders to meet and consider important issuesfacing the country. Read more: Morrison government loses fight for national cabinetsecrecy But even after that decision, both the Morrison and Albanesegovernments have refused Freedom of Information requests forNational Cabinet documents. [Extracted from the article]

Published
2023

42. Prediction of Adverse Maternal Outcomes in Preeclampsia: Development and Validation of the FullPIERS Model

Author

von Dadelszen, Peter, primary, Payne, Beth, additional, Li, Jing, additional, Ansermino, J. Mark, additional, Broughton Pipkin, Fiona, additional, Côté, Anne-Marie, additional, Douglas, M. Joanne, additional, Gruslin, Andrée, additional, Hutcheon, Jennifer A., additional, Joseph, K. S., additional, Kyle, Phillipa M., additional, Lee, Tang, additional, Loughna, Pamela, additional, Menzies, Jennifer M., additional, Merialdi, Mario, additional, Millman, Alexandra L., additional, Moore, M. Peter, additional, Moutquin, Jean-Marie, additional, Ouellet, Annie B., additional, Smith, Graeme N., additional, Walker, James J., additional, Walley, Keith R., additional, Walters, Barry N., additional, Widmer, Mariana, additional, Lee, Shoo K., additional, Russell, James A., additional, and Magee, Laura A., additional

Published
2011
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43. [1-OR]: The control of hypertension in pregnancy study (CHIPS) randomized controlled trial

Author

Magee, Laura A., von Dadelszen, Peter, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, Johanna, Singer, Joel, Gafni, Amiram, Gruslin, Andree, Helewa, Michael, Hutton, Eileen, Lee, Shoo K., Logan, Alexander G., Ganzevoort, Wessel, Welch, Ross, Thornton, Jim G., Moutquin, Jean-Marie, and The CHIPS Study Group

Published
2015
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44. [59-OR]: The control of hypertension in pregnancy study (CHIPS) randomized controlled trial – Is the type of antihypertensive important?

Author

Magee, Laura A., Dadelszen, Peter von, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, Johanna, Singer, Joel, Gafni, Amiram, Gruslin, Andree, Helewa, Michael, Hutton, Eileen, Lee, Shoo K., Logan, Alexander G., Ganzevoort, Wessel, Welch, Ross, Thornton, Jim G., and Moutquin, Jean-Marie

Published
2015
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47. PIERS Proteinuria: Relationship With Adverse Maternal and Perinatal Outcome

Author

Payne, Beth, Magee, Laura A., Côté, Anne-Marie, Hutcheon, Jennifer A., Li, Jing, Kyle, Phillipa M., Menzies, Jennifer M., Peter Moore, M., Parker, Claire, Pullar, Barbra, von Dadelszen, Peter, Walters, Barry N., von Dadelszen, P., Magee, L.A., Douglas, M.J., Walley, K.R., Russell, J.A., Lee, S.K., Gruslin, A., Smith, G.N., Côté, A.M., Moutquin, J.-M., Brown, M.A., Davis, G., Walters, B.N., Sass, N., Duan, T., Zhou, J., Mahajan, S., Noovao, A., McCowan, L.A., Kyle, P., Moore, M.P., Bhutta, S.Z., Bhutta, Z.A., Hall, Steyn, D.W., Broughton Pipkin, F., Loughna, P., Robson, S., de Swiet, M., Walker, J.J., Grobman, W.A., Lindheimer, M.D., Roberts, J.M., Mark Ansermino, J., Benton, Samantha, Cundiff, Geoff, Hugo, Dany, Joseph, K.S., Lalji, Sayrin, Li, Jing, Lott, Paula, Ouellet, Annie B., Shaw, Dorothy, Keith Still, D., Tawagi, George, Wagner, Brenda, Biryabarema, Christine, Mirembe, Florence, Nakimuli, Annettee, Tsigas, Eleni, Merialdi, Mario, and Widmer, Mariana

Abstract

To examine the ability of three different proteinuria assessment methods (urinary dipstick, spot urine protein:creatinine ratio [Pr/Cr], and 24-hour urine collection) to predict adverse pregnancy outcomes.

Published
2011
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49. The cost implications of less tight versus tight Control of Hypertension in Pregnancy (CHIPS Trial)novelty and significance

Author

Ahmed, Rashid J., Gafni, Amiram, Hutton, Eileen K., Hu, Zheng Jing, Pullenayegum, Eleanor, von Dadelszen, Peter, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, J. Johanna, Ganzevoort, Wessel, Helewa, Michael, Lee, Shoo K., Lee, Terry, Logan, Alexander G., Moutquin, Jean-Marie, Singer, Joel, Thornton, Jim, Welch, Ross, Magee, Laura A., Ahmed, Rashid J., Gafni, Amiram, Hutton, Eileen K., Hu, Zheng Jing, Pullenayegum, Eleanor, von Dadelszen, Peter, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, J. Johanna, Ganzevoort, Wessel, Helewa, Michael, Lee, Shoo K., Lee, Terry, Logan, Alexander G., Moutquin, Jean-Marie, Singer, Joel, Thornton, Jim, Welch, Ross, and Magee, Laura A.

Abstract

The CHIPS randomized controlled trial (Control of Hypertension in Pregnancy Study) found no difference in the primary perinatal or secondary maternal outcomes between planned “less tight” (target diastolic 100 mm Hg) and “tight” (target diastolic 85 mm Hg) blood pressure management strategies among women with chronic or gestational hypertension. This study examined which of these management strategies is more or less costly from a third-party payer perspective. A total of 981 women with singleton pregnancies and nonsevere, nonproteinuric chronic or gestational hypertension were randomized at 14 to 33 weeks to less tight or tight control. Resources used were collected from 94 centers in 15 countries and costed as if the trial took place in each of 3 Canadian provinces as a cost-sensitivity analysis. Eleven hospital ward and 24 health service costs were obtained from a similar trial and provincial government health insurance schedules of medical benefits. The mean total cost per woman–infant dyad was higher in less tight versus tight control, but the difference in mean total cost (DM) was not statistically significant in any province: Ontario ($30191.62 versus $24469.06; DM $5723, 95% confidence interval, −$296 to $12272; P=0.0725); British Columbia ($30593.69 versus $24776.51; DM $5817; 95% confidence interval, −$385 to $12349; P=0.0725); or Alberta ($31510.72 versus $25510.49; DM $6000.23; 95% confidence interval, −$154 to $12781; P=0.0637). Tight control may benefit women without increasing risk to neonates (as shown in the main CHIPS trial), without additional (and possibly lower) cost to the healthcare system.

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50. Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study)

Author

Vidler, Marianne, Magee, Laura A., von Dadelszen, Peter, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, Johanna, Singer, Joel, Gafni, Amiram, Gruslin, Andrée, Helewa, Michael, Hutton, Eileen, Lee, Shoo K., Lee, Terry, Logan, Alexander G., Ganzevoort, Wessel, Welch, Ross, Thornton, Jim, Moutquin, Jean-Marie, Vidler, Marianne, Magee, Laura A., von Dadelszen, Peter, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, Johanna, Singer, Joel, Gafni, Amiram, Gruslin, Andrée, Helewa, Michael, Hutton, Eileen, Lee, Shoo K., Lee, Terry, Logan, Alexander G., Ganzevoort, Wessel, Welch, Ross, Thornton, Jim, and Moutquin, Jean-Marie

Abstract

Objective: To compare women’s views about blood pressure (BP) control in CHIPS (Control of Hypertension In Pregnancy Study) (NCT01192412). Design: Quantitative and qualitative analysis of questionnaire responses. Setting: International randomised trial (94 sites, 15 countries). Population/sample: 911 (92.9%) women randomised to ‘tight’ (target diastolic blood pressure, 85 mmHg) or ‘less tight’ (target diastolic blood pressure, 100 mmHg) who completed questionnaires. Methods: A questionnaire was administered at ~6–12 weeks postpartum regarding post-discharge morbidity and views about trial participation. Questionnaires were administered by the site co-ordinator, and contact was made by phone, home or clinic visit; rarely, data was collected from medical records. Quantitative analyses were Chi-square or Fisher’s exact test for categorical variables, mixed effects multinomial logistic regression to adjust for confounders, and p<0.001 for statistical significance. NVivo software was used for thematic analysis of women’s views. Main outcome measures: Satisfaction, measured as willingness to have the same treatment in another pregnancy or recommend that treatment to a friend. Results: Among the 533 women in ‘tight’ (N= 265) vs. ‘less tight’ (N= 268) control who providedcomments for qualitative analysis, women in ‘tight’ (vs. ‘less tight’) control made fewer positive comments about the amount of medication taken (5 vs. 28 women, respectively) and intensity of BP monitoring (7 vs. 17, respectively). However, this did not translate into less willingness to either have the same treatment in another pregnancy (434, 95.8% vs. 423, 92.4%, respectively; p= 0.14) or recommend that treatment to a friend (435, 96.0% and 428, 93.4%, respectively; p= 0.17). Importantly, although satisfaction remained high among women with an adverse outcome, those in ‘tight’ control who suffered an adverse outcome (vs. those who did not) were not consistently less satisfied, whereas this was not the c

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