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1. Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study

Author

Menze, Inga, Bernal, Jose, Kaya, Pinar, Aki, Çağla, Pfister, Malte, Geisendörfer, Jonas, Yakupov, Renat, Coello, Roberto Duarte, Valdés-Hernández, Maria d. C., Heneka, Michael T., Brosseron, Frederic, Schmid, Matthias C., Glanz, Wenzel, Incesoy, Enise I., Butryn, Michaela, Rostamzadeh, Ayda, Meiberth, Dix, Peters, Oliver, Preis, Lukas, Lammerding, Dominik, Gref, Daria, Priller, Josef, Spruth, Eike J., Altenstein, Slawek, Lohse, Andrea, Hetzer, Stefan, Schneider, Anja, Fliessbach, Klaus, Kimmich, Okka, Vogt, Ina R., Wiltfang, Jens, Bartels, Claudia, Schott, Björn H., Hansen, Niels, Dechent, Peter, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Goerss, Doreen, Laske, Christoph, Munk, Matthias H., Sanzenbacher, Carolin, Hinderer, Petra, Scheffler, Klaus, Spottke, Annika, Roy-Kluth, Nina, Lüsebrink, Falk, Neumann, Katja, Wardlaw, Joanna, Jessen, Frank, Schreiber, Stefanie, Düzel, Emrah, and Ziegler, Gabriel more...

Published
2024
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2. Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults

Author

Bernal, Jose, Menze, Inga, Yakupov, Renat, Peters, Oliver, Hellmann-Regen, Julian, Freiesleben, Silka Dawn, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Schott, Björn H., Jessen, Frank, Rostamzadeh, Ayda, Glanz, Wenzel, Incesoy, Enise I., Buerger, Katharina, Janowitz, Daniel, Ewers, Michael, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Sodenkamp, Sebastian, Spottke, Annika, Esser, Anna, Lüsebrink, Falk, Dechent, Peter, Hetzer, Stefan, Scheffler, Klaus, Schreiber, Stefanie, Düzel, Emrah, and Ziegler, Gabriel more...

Published
2024
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3. Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study

Author

Bernal, Jose, Schreiber, Stefanie, Menze, Inga, Ostendorf, Anna, Pfister, Malte, Geisendörfer, Jonas, Nemali, Aditya, Maass, Anne, Yakupov, Renat, Peters, Oliver, Preis, Lukas, Schneider, Luisa, Herrera, Ana Lucia, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Schott, Björn H., Rostamzadeh, Ayda, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Ewers, Michael, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Dobisch, Laura, Dechent, Peter, Scheffler, Klaus, Hetzer, Stefan, Wolfsgruber, Steffen, Kleineidam, Luca, Schmid, Matthias, Berger, Moritz, Jessen, Frank, Wirth, Miranka, Düzel, Emrah, and Ziegler, Gabriel more...

Published
2023
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6. The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer’s Disease in Subjective Cognitive Decline

Author

Schmicker, Marlen, Frühling, Insa, Menze, Inga, Glanz, Wenzel, Müller, Patrick, Noesselt, Toemme, and Müller, Notger G.

Subjects
taste, Psychiatry and Mental health, Clinical Psychology, diagnostic marker, General Neuroscience, ddc:610, subjective cognitive decline, Geriatrics and Gerontology, Alzheimer’s disease, dementia, early diagnosis
Abstract

Background: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer’s disease (AD) although psychophysical testing does not reveal any cognitive deficit. Objective: Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD. Methods: Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD–) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin’ Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration. Results: Only taste was able to distinguish between HC/SCD– and SCD+ patients. Conclusion: This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition. more...

Published
2023
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7. Perivascular spaces in the brain enlarge over time; A three‐year longitudinal study

Author

Bernal, Jose, primary, Menze, Inga, additional, Yakupov, Renat, additional, Kaya, Pinar, additional, Aki, Cagla, additional, Pfister, Malte, additional, Geisendörfer, Jonas, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Fließbach, Klaus, additional, Wiltfang, Jens, additional, Buerger, Katharina, additional, Perneczky, Robert, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Spottke, Annika, additional, Heneka, Michael T., additional, Wagner, Michael, additional, Ramirez, Alfredo, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Jessen, Frank, additional, Schreiber, Stefanie, additional, Düzel, Emrah, additional, and Ziegler, Gabriel, additional more...

Published
2023
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8. Altered Resting‐state fMRI BOLD Signal Fluctuations in the Spectrum of Alzheimer’s Dementia and in Patients with White Matter Hyperintensities

Author

Behrenbruch, Niklas, primary, Incesoy, Enise I, additional, Bernal, Jose, additional, Menze, Inga, additional, Vockert, Niklas, additional, Kleineidam, Luca, additional, Buerger, Katharina, additional, Wolfsgruber, Steffen, additional, Spottke, Annika, additional, Fließbach, Klaus, additional, Laske, Christoph, additional, Perneczky, Robert, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Heneka, Michael T., additional, Wagner, Michael, additional, Tipel, Stefan, additional, Wiltfang, Jens, additional, Speck, Oliver, additional, Perosa, Valentina, additional, Yakupov, Renat, additional, Jessen, Frank, additional, Düzel, Emrah, additional, Mattern, Hendrik, additional, Schreiber, Stefanie, additional, Ziegler, Gabriel, additional, and Maass, Anne, additional more...

Published
2023
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9. Contributions of enlarged perivascular spaces and white matter hyperintensities to cognitive performance in the Alzheimer’s disease continuum – shared and unique effects

Author

Menze, Inga, primary, Bernal, Jose, additional, Yakupov, Renat, additional, Kaya, Pinar, additional, Aki, Cagla, additional, Pfister, Malte, additional, Geisendörfer, Jonas, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Fliessbach, Klaus, additional, Wiltfang, Jens, additional, Bürger, Katharina, additional, Perneczky, Robert, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Spottke, Annika, additional, Heneka, Michael T., additional, Wagner, Michael, additional, Ramirez, Alfredo, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Jessen, Frank, additional, Schreiber, Stefanie, additional, Düzel, Emrah, additional, and Ziegler, Gabriel, additional more...

Published
2023
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10. Altered BOLD Signal Fluctuations in precuneus relate to inflammatory markers and vascular risk in the AD spectrum

Author

Maass, Anne, primary, Behrenbruch, Niklas, additional, Incesoy, Enise I, additional, Brosseron, Frederic, additional, Menze, Inga, additional, Bernal, Jose, additional, Hayek, Dayana, additional, Kleineidam, Luca, additional, Bürger, Katharina, additional, Fliessbach, Klaus, additional, Laske, Christoph, additional, Perneczky, Robert, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Spottke, Annika, additional, Teipel, Stefan, additional, Wiltfang, Jens, additional, Wolfsgruber, Steffen, additional, Yakupov, Renat, additional, Wagner, Michael, additional, Jessen, Frank, additional, Duzel, Emrah, additional, Schreiber, Stefanie, additional, Heneka, Michael T., additional, and Ziegler, Gabriel, additional more...

Published
2023
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11. Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age—Results from the Multicentre Observational DELCODE Study.

Author

Dörner, Marc, Seebach, Katharina, Heneka, Michael T., Menze, Inga, von Känel, Roland, Euler, Sebastian, Schreiber, Frank, Arndt, Philipp, Neumann, Katja, Hildebrand, Annkatrin, John, Anna-Charlotte, Tyndall, Anthony, Kirchebner, Johannes, Tacik, Pawel, Jansen, Robin, Grimm, Alexander, Henneicke, Solveig, Perosa, Valentina, Meuth, Sven G., and Peters, Oliver more...

Subjects
AMYLOID, MAGNETIC resonance imaging, OPTIMISM, ALZHEIMER'S disease, MINI-Mental State Examination
Abstract

Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless needed to confirm them as an imaging biomarker. We investigated whether IFSHs were tied to Alzheimer's disease (AD) pathology and cognitive performance. We used data from 361 participants along the AD continuum, who were enrolled in the multicentre DELCODE study. The IFSHs were rated visually based on FLAIR magnetic resonance imaging. We performed ordinal regression to examine the relationship between the IFSHs and cerebrospinal fluid-derived amyloid positivity and tau positivity (Aβ42/40 ratio ≤ 0.08; pTau181 ≥ 73.65 pg/mL) and linear regression to examine the relationship between cognitive performance (i.e., Mini-Mental State Examination and global cognitive and domain-specific performance) and the IFSHs. We controlled the models for age, sex, years of education, and history of hypertension. The IFSH scores were higher in those participants with amyloid positivity (OR: 1.95, 95% CI: 1.05–3.59) but not tau positivity (OR: 1.12, 95% CI: 0.57–2.18). The IFSH scores were higher in older participants (OR: 1.05, 95% CI: 1.00–1.10) and lower in males compared to females (OR: 0.44, 95% CI: 0.26–0.76). We did not find sufficient evidence linking the IFSH scores with cognitive performance after correcting for demographics and AD biomarker positivity. IFSHs may reflect the aberrant accumulation of amyloid β beyond age. [ABSTRACT FROM AUTHOR] more...

Published
2024
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12. Perivascular space enlargement accelerates with hypertension, white matter hyperintensities, chronic inflammation, and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study

Author

Menze, Inga, primary, Bernal, Jose, additional, Kaya, Pinar, additional, Aki, Çağla, additional, Pfister, Malte, additional, Geisendörfer, Jonas, additional, Yakupov, Renat, additional, Heneka, Michael T., additional, Brosseron, Frederic, additional, Schmid, Matthias C., additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Butryn, Michaela, additional, Rostamzadeh, Ayda, additional, Meiberth, Dix, additional, Peters, Oliver, additional, Preis, Lukas, additional, Lammerding, Dominik, additional, Gref, Daria, additional, Priller, Josef, additional, Spruth, Eike J., additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Hetzer, Stefan, additional, Schneider, Anja, additional, Fliessbach, Klaus, additional, Kimmich, Okka, additional, Vogt, Ina R., additional, Wiltfang, Jens, additional, Bartels, Claudia, additional, Schott, Björn H., additional, Hansen, Niels, additional, Dechent, Peter, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Perneczky, Robert, additional, Rauchmann, Boris-Stephan, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Goerss, Doreen, additional, Laske, Christoph, additional, Munk, Matthias H., additional, Sanzenbacher, Carolin, additional, Hinderer, Petra, additional, Scheffler, Klaus, additional, Spottke, Annika, additional, Roy-Kluth, Nina, additional, Lüsebrink, Falk, additional, Neumann, Katja, additional, Jessen, Frank, additional, Schreiber, Stefanie, additional, Düzel, Emrah, additional, and Ziegler, Gabriel, additional more...

Published
2023
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13. Individual response to transcranial direct current stimulation as a function of working memory capacity and electrode montage

Author

Menze, Inga, Müller, Notger, Zähle, Tino, and Schmicker, Marlen

Subjects
Behavioral Neuroscience, Psychiatry and Mental health, Neuropsychology and Physiological Psychology, Neurology, working memory capacity, distractor inhibition, electrode montage, ddc:610, frontoparietal network, individual differences, tDCS, Biological Psychiatry
Abstract

IntroductionAttempts to improve cognitive abilities via transcranial direct current stimulation (tDCS) have led to ambiguous results, likely due to the method’s susceptibility to methodological and inter-individual factors. Conventional tDCS, i.e., using an active electrode over brain areas associated with the targeted cognitive function and a supposedly passive reference, neglects stimulation effects on entire neural networks.MethodsWe investigated the advantage of frontoparietal network stimulation (right prefrontal anode, left posterior parietal cathode) against conventional and sham tDCS in modulating working memory (WM) capacity dependent transfer effects of a single-session distractor inhibition (DIIN) training. Since previous results did not clarify whether electrode montage drives this individual transfer, we here compared conventional to frontoparietal and sham tDCS and reanalyzed data of 124 young, healthy participants in a more robust way using linear mixed effect modeling.ResultsThe interaction of electrode montage and WM capacity resulted in systematic differences in transfer effects. While higher performance gains were observed with increasing WM capacity in the frontoparietal stimulation group, low WM capacity individuals benefited more in the sham condition. The conventional stimulation group showed subtle performance gains independent of WM capacity.DiscussionOur results confirm our previous findings of WM capacity dependent transfer effects on WM by a single-session DIIN training combined with tDCS and additionally highlight the pivotal role of the specific electrode montage. WM capacity dependent differences in frontoparietal network recruitment, especially regarding the parietal involvement, are assumed to underlie this observation. more...

Published
2023
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14. Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: A cross-sectional study

Author

Bernal, Jose, primary, Schreiber, Stefanie, additional, Menze, Inga, additional, Ostendorf, Anna, additional, Pfister, Malte, additional, Geisendörfer, Jonas, additional, Nemali, Aditya, additional, Maass, Anne, additional, Yakupov, Renat, additional, Peters, Oliver, additional, Preis, Lukas, additional, Schneider, Luisa, additional, Herrera, Ana Lucia, additional, Priller, Josef, additional, Spruth, Eike Jakob, additional, Altenstein, Slawek, additional, Schneider, Anja, additional, Fliessbach, Klaus, additional, Wiltfang, Jens, additional, Schott, Björn H., additional, Rostamzadeh, Ayda, additional, Glanz, Wenzel, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Ewers, Michael, additional, Perneczky, Robert, additional, Rauchmann, Boris-Stephan, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Laske, Christoph, additional, Munk, Matthias H., additional, Spottke, Annika, additional, Roy, Nina, additional, Dobisch, Laura, additional, Dechent, Peter, additional, Scheffler, Klaus, additional, Hetzer, Stefan, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Schmid, Matthias, additional, Berger, Moritz, additional, Jessen, Frank, additional, Wirth, Miranka, additional, Düzel, Emrah, additional, and Ziegler, Gabriel, additional more...

Published
2022
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16. Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double-blinded crossover study

Author

Instituto de Salud Carlos III, European Commission, Projekt DEAL, Müller, Patrick, Vellage, Anne-Katrin, Schmicker, Marlen, Menze, Inga, Grothe, Michel J., Teipel, Stefan J., Müller, Notger G., Instituto de Salud Carlos III, European Commission, Projekt DEAL, Müller, Patrick, Vellage, Anne-Katrin, Schmicker, Marlen, Menze, Inga, Grothe, Michel J., Teipel, Stefan J., and Müller, Notger G. more...

Abstract

[Introduction] Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non-responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors., [Methods] Here we investigate structural magnetic resonance imaging of the basal forebrain cholinergic system volume (BFvol) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n = 18; 59 to 75 years)., [Results] We observed that the cognitive response to galantamine, more specifically the attention-dependent filtering performance in a delayed match-to-sample working memory task, correlated with BFvol: Only participants with high BFvol showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process., [Discussion] Future studies need to assess whether BFvol may serve as a predictor of the galantamine response in AD patients, too. more...

Published
2021

20. Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults-A randomized controlled double-blinded crossover study.

Author

Müller P, Vellage AK, Schmicker M, Menze I, Grothe MJ, Teipel SJ, and Müller NG

Abstract

Introduction: Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non-responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors., Methods: Here we investigate structural magnetic resonance imaging of the basal forebrain cholinergic system volume (BF vol ) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n = 18; 59 to 75 years)., Results: We observed that the cognitive response to galantamine, more specifically the attention-dependent filtering performance in a delayed match-to-sample working memory task, correlated with BF vol : Only participants with high BF vol showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process., Discussion: Future studies need to assess whether BF vol may serve as a predictor of the galantamine response in AD patients, too., Competing Interests: The authors declare that they have no conflicts of interest., (© 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.) more...

Published
2021
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