1. The Wonderful Activities of the Genus
- Author
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Muhammad Imran, Somesh Sharma, Patrick Valere Tsouh Fokou, Ruchi Sharma, Tabussam Tufail, Tanweer Aslam Gondal, Gianluca Caruso, Raffaele Pezzani, Majid Tafrihi, Maria Atanassova, Lyubomir M. Atanassov, Tafrihi, M., Imran, M., Tufail, T., Gondal, T. A., Caruso, G., Sharma, S., Sharma, R., Atanassova, M., Atanassov, L., Fokou, P. V. T., and Pezzani, R.
- Subjects
Antioxidant ,medicine.medical_treatment ,Phytochemicals ,Pharmaceutical Science ,Bacillus subtilis ,Review ,Biology ,anticancer ,01 natural sciences ,essential oil ,Antioxidants ,Analytical Chemistry ,lcsh:QD241-441 ,03 medical and health sciences ,lcsh:Organic chemistry ,Picrates ,Drug Discovery ,medicine ,Oils, Volatile ,Humans ,Physical and Theoretical Chemistry ,Cytotoxicity ,Medicinal plants ,Protein kinase B ,essential oils ,PI3K/AKT/mTOR pathway ,030304 developmental biology ,Cell Proliferation ,0303 health sciences ,Traditional medicine ,Mentha, phytochemical ,Bacteria ,Organic Chemistry ,Biphenyl Compounds ,Antimicrobial ,biology.organism_classification ,Antineoplastic Agents, Phytogenic ,mint ,0104 chemical sciences ,Mentha, phytochemicals ,Anti-Bacterial Agents ,010404 medicinal & biomolecular chemistry ,Chemistry (miscellaneous) ,Cancer cell ,Molecular Medicine ,antimicrobial ,Mentha - Abstract
Medicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health. Among medicinal plants, mint (Mentha species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. Mentha species are widely used in savory dishes, food, beverages, and confectionary products. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways; they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Essential oils from mint have also been found to exert antibacterial activities against Bacillus subtilis, Streptococcus aureus, Pseudomonas aeruginosa, and many others. The current review highlights the antimicrobial role of mint-derived compounds and essential oils with a special emphasis on anticancer activities, clinical data and adverse effects displayed by such versatile plants.
- Published
- 2021