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AbstractThis paper proposes a new method using Artificial Neural Network (ANN) for detection of different Inter Turn Short Circuit (ITSC) faults in an induction motor under different loading conditions. The stator current signal was obtained experimentally from a healthy motor and a faulty motor with ITSC faults. The statistical time domain features was extracted from stator current signal, these features are used to train and test an ANN in order to diagnose ITSC faults. A complete study is performed by considering various diagnosis methods from ANN and machine learning algorithms, including Decision Tree (DT), K-Nearest Neighbours (KNN), Naive Bayes (NB), Random Forest (RF) and Support Vector Machine (SVM) for diagnosis ITSC faults. The performance of the proposed method was compared with machine learning algorithms, the proposed method has a higher accuracy than the other algorithms. Trained neural networks are able to classify different states of the ITSC faults with satisfied accuracy. The efficiency of this approach has been proven using experimental tests to diagnose ITCS faults in a 1.5Hp squirrel cage induction motor.

This paper proposes an Adaptive Neural Fuzzy Inference System (ANFIS) model for diagnosis of combined Inter Turn Short Circuit (ITSC) and Broken Rotor Bar (BRB) faults in a Squirrel Cage Induction Motor (SC-IM). The signal of the stator current is obtained from a really healthy and faulty SC-IM. Experimental tests have been set up using a 1.5 Hp/380 V three-phase SC-IM with different combined ITSC and BRB faults under different loading conditions. Before entering the model, the Discrete Wavelet Transform (DWT) pre-processes the stator current signal. The DWT generates data sets in order to evaluate the proposed technique. ANFIS based on DWT is used successfully to diagnose the most relevant faults very effectively. In addition, ANFIS based on the DWT method has been compared to ANFIS and ANFIS based on an auto-regressive model, finding that the proposed method achieves higher efficiency than the previous one. The proposed ANFIS based on the DWT model classifies entirely different states of combined ITSC and BRB faults with high accuracy.

A new series of 8-methoxy-2-trimethoxyphenyl-3-substituted quinazoline-4(3)-one compounds were designed, synthesized, and screened for antitumor activity against three cell lines, namely, Hela, A549, and MDA compared to docetaxel as reference drug. The molecular docking was performed using Autodock Vina program and 20 ns molecular dynamics (MD) simulation was performed using GROMACS 2018.1 software. Compound 6 was the most potent antitumor of the new synthesized compounds and was evaluated as a VEGFR2 and EGFR inhibitor with (IC50, 98.1 and 106 nM respectively) compared to docetaxel (IC50, 89.3 and 56.1 nM respectively). Compounds 2, 6, 10, and 8 showed strong cytotoxic activities against the Hela cell line with IC50 of, 2.13, 2.8, 3.98, and 4.94 µM, respectively, relative to docetaxel (IC50, 9.65 µM). Compound 11 showed strong cytotoxic activity against A549 cell line (IC50, 4.03 µM) relative to docetaxel (IC50, 10.8 µM). Whereas compounds 6 and 9 showed strong cytotoxic activity against MDA cell line (IC50, 0.79, 3.42 µM, respectively) as compared to docetaxel (IC50, 3.98 µM).

The study assessed the efficacy of parsley and dill essential oils (EOs) nanocapsules incorporated into fermented milk in hepato-renal protection against specific food additives. A molecular docking assay was conducted between parsley and dill EOs bioactive molecules and inflammatory cytokines. Freeze-dried parsley and dill EOs nanocapsules were developed, characterized for their morphological structure, particle size, zeta potential, polydispersity index and encapsulation efficiency and assessed in fast green dye and sodium benzoate (SB) combination-treated rats. The docking results revealed that the primary constituents of parsley and dill EOs (apiol, myristicin, α-pinene, (−)-carvone, and d-limonene) interacted with the active sites of TNF-α, IL-1β and TGF-1β cytokines with hydrophobic and hydrogen bond interactions. D-limonene had the highest binding affinity (6.4 kcal/mol) for the TNF-α. Apiol and myristicin had the highest binding affinity (5.1, 5.0, 5.0 and 5.0 kcal/mol, respectively) for the IL-1β and TGF-β1 receptors. Biochemically and histopathologically, the excessive co-administration of fast green and SB revealed adverse effects on the liver and the kidney. Whereas the treatment with parsley and dill EOs nanocapsules afford hepato-renal protective effects as manifested by suppression the elevated liver and kidney functions. Parsley and dill EOs nanocapsules showed a significant reduction of the liver (64.08 and 80.5 pg/g, respectively) and kidney (59.3 and 83.6 pg/g, respectively) ROS. Moreover, parsley and dill EOs nanocapsules down-regulated the liver and the kidney inflammatory cytokines (IL-6, TNF-α, IL-1β and TGF-1β) and lipid peroxidation and up-regulated the antioxidant enzymes. In conclusion, the data suggest a potential hepato-renal protective effects of parsley and dill EOs nanocapsules.

Purpose To outline the prevalence of vitamin D and vitamin B12 deficiencies in enuretic children.Methods An analytical descriptive study was conducted on enuretic children who were followed up at the outpatient clinic for nocturnal enuresis at the Children’s Hospital, Cairo University. Sociodemographic and clinical data were recorded. The levels of vitamin D and vitamin B12 were assessed and correlated with the severity of enuresis.Results Two hundred and eighty-eight children were enrolled. Insufficiency of Vitamin D predominated (n = 139; 48.3%). Vitamin D deficiency was present in 31.3%, n = 90 and it was normal in 20.5%, n = 59). Vitamin B12 deficiency was observed in 25% of the studied children, n = 72). The one-sample Wilcoxon signed-rank test was significant for both vitamins (P value =0.001). Vitamin D showed a stronger inverse correlation with the number of enuresis episodes per day than vitamin B12 (-0.680 vs. −0.219 respectively). A cut-off of 13.7 ng/ml for vitamin D was detected, below which the child was predicted to have failed dry nights. Using multivariate logistic regression, higher vitamin D levels and behavioural treatment coexistence were significant protective factors for the absence of dry nights.Conclusion Low levels of vitamin D and B12 were detected in children with primary nocturnal enuresis, which could be considered a burden on the clinical severity of enuresis.

Abstract Objective This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients’ outcomes. Methods SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls. Results Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P =

The objectives of the current study were to determine the prevalence of Cryptosporidium spp. infections in diarrheic calves reared in different localities in Egypt under different management systems, to clarify the role of the associated epidemiologic risk factors, and to identify the circulating Cryptosporidium spp. on molecular basis. A total of 222 diarrheic calves (180 cattle and 42 buffaloes) were used in this study. The presence of the protozoan was proven by microscopic screening of the oocysts using a modified Ziehl-Neelsen staining technique followed by two-step nested PCR for the gp60 gene. Cryptosporidium oocysts were detected microscopically in 75 of 222 (33.78%) fecal samples, of which 71 (39.44 %) fecal samples were obtained from cattle calves and 4 (9.52 %) fecal samples were obtained from buffalo calves. The gp60 gene-based PCR was positive in 63 (84%) fecal samples, of which 59 (83.1%) fecal samples were obtained from cattle calves and 4 (100 %) fecal samples were obtained from buffalo calves. The sequences belonged to C. parvum subtype family IIa; an important zoonotic C. parvum . C. parvum isolates in this study belonged to an uncommon C. parvum subtype family, especially ACATCA preceding the trinucleotide repeat. Different risk epidemiologic factors were verified to influence the prevalence of Cryptosporidium spp. infections in the current study. The high prevalence recorded in this study and the enzootic nature of cryptosporidiosis in calves have been evidenced in this study in different localities in Egypt associated with lack of hygienic measures as well as different epidemiologic variables. Further studies are needed to illustrate the effect of heterogenicity of the obtained sequences on the biology of the parasite with public health significance.

This article proposes the novel understanding of the Egyptian Muslim Brotherhood as a sect, going against the grain of the existing literature, which posits it as a political group, a social movement, or a religious movement (or some combination of all of the above). The sectarianisation occurs within the group via ideological build-up, organisational tactics, and internal socialisation of behaviour. The group is also a sect by constituting its unique identity in opposition to external actors. To make the argument, the analysis draws on the statements of key figures within the movement’s history, such as its founder Hasan al-Banna, as well as a range of interviews with current and ex-members. My argument has two main consequences for our understanding of sectarianism in general and the Brotherhood in particular. First, sectarianism is a process of sectarianisation that operates beyond the state and at lower levels, such as groups and individuals. Second, the Brotherhood is not a mere victim of the sectarianising practices of the state. Its sectarianisation is partly of its own making.

This investigation explores the effects of applying fuzzy time series (FTSs) based on neural network models for estimating a variety of spectral functions in integer time series models. The focus is particularly on the skew integer autoregressive of order one (NSINAR(1)) model. To support this estimation, a dataset consisting of NSINAR(1) realizations with a sample size of n = 1000 is created. These input values are then subjected to fuzzification via fuzzy logic. The prowess of artificial neural networks in pinpointing fuzzy relationships is harnessed to improve prediction accuracy by generating output values. The study meticulously analyzes the enhancement in smoothing of spectral function estimators for NSINAR(1) by utilizing both input and output values. The effectiveness of the output value estimates is evaluated by comparing them to input value estimates using a mean-squared error (MSE) analysis, which shows how much better the output value estimates perform.

This investigation was conducted to evaluate pod and chemical component traits and the genetic diversity of Prosopis juliflora genotypes at two locations. The selected locations were in the middle (Qassim region) and western (Jeddah region) areas, representing two agro-climatic zones of Saudi Arabia. The measured pod characteristics included production, weight, length, filling period, and chemical composition. A wide range of variations in pod yield and chemical traits were observed in the different agro-climatic regions. The results revealed that the mean values ranged from 9.5 kg tree−1 (Jeddah) to 14.2 kg tree−1 (Qassim) for pod yield, 3.1 g pod−1 (Qassim) to 3.7 g pod−1 (Jeddah) for pod weight, and 14.8 cm (Qassim) to 16.6 cm (Jiddah) for pod length. The results of genetic diversity indicated that Prosopis genotypes in each location were distributed in three different clusters in the two regions at 60 Euclidean distances. The principal component analysis (PCA) showed that the two components (PC1 and PC2) explained 25.03 % and 20.03 % of the overall variance, respectively, which is over 45 % of the variability. The heatmap revealed that genotypes Q20, Q21, and Q24 at the Qassim location and genotypes J1, J6, and J7 at the Jiddah location exhibited positive and significant correlations with pod yield. It can be concluded that superior Prosopis genotypes (Q20, Q21, Q24, J1, J6, and J7) were identified with good traits (pod yield, pod-filling period, and protein %) in each location and may be used in the future for the selection of elite genotypes.

Background: Due to Egypt's strategic location among countries, transportation is one of the most significant development sectors because it plays a major part in today's economy and society and has a large influence on growth and employment. Over the years, the Egyptian General Organisation of Physical Planning (GOPP) has prepared strategic general urban plans in collaboration with local and foreign organisations, including transportation plans. The constant focus of authorities on strategic plans and their inability to implement them on schedule are a major issue. In other words, they always take development from a distant perspective and do not deal with the main problem that exists within cities, as the existing micro-scale transit built environments (MSTBEs) of cities are not ready due to a lack of transit-oriented communities (TOCs), sustainably developed transit supply systems, and mobility hubs. Methods: The 'Enhanced MSTBE Phases' methodology is used for the key elements of the study design used in this research, depending on data collection, approvals, techniques, and analysis methods. As a case study, these key elements are in the documentation, analysis, and development of the Muharram Bek El Mowkaf El Gedid Mobility Hub (MBMH) and the 800 m radius around it. Results: The results indicate that Enhanced MSTBE Phases led to the establishment of the MBMH and the 800 m radius surrounding it as a sustainable MSTBE in Alexandria, Egypt, which is chosen as the case study. Conclusions: The development of this MSTBE is a catalyst for future effects that will have a long-term impact on meso-scale and, ultimately, macro-scale transit built environments.

Background: Throughout the history of the city, the architecture of Alexandria, Egypt, has been in contact with world cultures, especially those of the Mediterranean sphere. Alexandria is rich with cultural features dating back seven thousand years. In Alexandria, the heritage value of the city has decreased since the beginning of the third millennium of the Common Era because there is no suitable digital documentation system for these more recent assets. The development of a new technique for preserving heritage buildings is required. For example, image- based techniques can gather data using photography, panoramic photography, and close-range photogrammetry. In this research, we primarily seek to implement Heritage Digitisation Process Phases (HDPP) by introducing both the Building Information Modelling (BIM) environment and the point clouds for achieving a Historic Building Information Modelling (HBIM) model and to establish new documentation methods in architectural conservation and built-heritage preservation, i.e., Virtual Reality (VR) and Website Heritage Documentation (WHD). Methods: The methodology is designed to preserve and manage cultural heritage using HDPP for the promotion of heritage building preservation in Alexandria. Results: The results show that the application of HDPP has led to the creation of a digital database about the Société Immobilière building, which was chosen as a case study for this research. Conclusions: Implementation of HDPP and usage of new documentation methods i.e., VR and WHD create a digital path to help strengthen its image and connect the place to users, recreational areas are created to communicate and explore the city’s architectural history.

Background: Due to Egypt's strategic location among countries, transportation is one of the most significant development sectors because it plays a major part in today's economy and society and has a large influence on growth and employment. Over the years, the Egyptian General Organisation of Physical Planning (GOPP) has prepared strategic general urban plans in collaboration with local and foreign organisations, including transportation plans. The constant focus of authorities on strategic plans and their inability to implement them on schedule are a major issue. In other words, they always take development from a distant perspective and do not deal with the main problem that exists within cities, as the existing micro-scale transit built environments (MSTBEs) of cities are not ready due to a lack of transit-oriented communities (TOCs), sustainably developed transit supply systems, and mobility hubs. Methods: The 'Enhanced MSTBE Phases' methodology is used for the key elements of the study design used in this research, depending on data collection, approvals, techniques, and analysis methods. As a case study, these key elements are in the documentation, analysis, and development of the Muharram Bek El Mowkaf El Gedid Mobility Hub (MBMH) and the 800 m radius around it. Results: The results indicate that Enhanced MSTBE Phases led to the establishment of the MBMH and the 800 m radius surrounding it as a sustainable MSTBE in Alexandria, Egypt, which is chosen as the case study. Conclusions: The development of this MSTBE is a catalyst for future effects that will have a long-term impact on meso-scale and, ultimately, macro-scale transit built environments.

Background: Bladder cancer is still the most common cancer of the bladder tract and the ninth most common cancer in the world. Most people who get bladder cancer have nonmuscle invasive bladder cancer (NMIBC), which has a much lower death rate than muscle invasive bladder cancer. Urologists are now more interested in enbloc removal of bladder tumor (ERBT), but there are only a few small studies that look at hydrodissemination during ERBT. ERBT gives a lot of detrusor muscle samples (more than 95%) and good samples for figuring out what's wrong. So far, it hasn't been looked into whether second resections can be avoided. All energy tools, like lasers and electric cautery, have been used to do ERBT with the same positive effects on the patient and the cancer. Conclusions: The numbers show that there isn't a big difference between normal and perioperative morbidity transurethral resection of bladder tumors, but only a few of the papers used a structured way to group them. There are no conclusions that can be made about how ERBT affects recurrence. [ABSTRACT FROM AUTHOR]

Background: Carbapenem-resistant Enterobacterales (CRE) have been identified as a public health problem. Treatment options for CRE are limited as they are mostly resistant to βeta-lactams, aminoglycosides, and fluoroquinolones as well as carbapenems. The present study aims to evaluate the performance of three phenotypic methods compared to a molecular-based technique for carbapenemase detection in Enterobacterales and determining their applicability in clinical and epidemiological settings. Methods: A total of 1,158 Enterobacterales were isolated from the urine samples in the microbiology laboratory of Alexandria main university hospital during the period from April 2020 to April 2021. Fifty randomly selected (39 Klebsiella and 11 E. coli) Enterobacterales were screened for carbapenem resistance by disc diffusion method. They were subjected to 3 phenotypic tests which are: Carba NP method, Modified carbapenem inactivation method (m CIM) and EDTA- modified carbapenem inactivation method (e CIM). Detection of 5 carbapenemase genes (blaKPC, blaIMP, blaVIM, blaOXA-48 and blaNDM-1) was performed using real time PCR. Results: CRE represented 33% of Enterobacterales isolates. Twenty-six cases (52%) were males and 94% of the cases were above 40 years old. Carba NP test was positive in 43/50 (86%) of the selected isolates, m CIM was positive in 35/50 (70%) and e CIM was positive in 30/50 (60%). The most common carbapenemase gene detected was blaNDM-1 (94%), followed by blaOXA-48 gene (72%) and blaVIM gene (24%). The blaKPC gene and blaIMP gene were not detected. Coexistence of the blaOXA-48 and the blaNDM-1 genes was detected in 48% isolates, while the blaNDM-1, the blaOXA-48 and the blaVIM genes were found in 22% isolates. The sensitivity of Carba NP, m CIM and e CIM was 87.5%, 72.9%, and 85.7% respectively. Conclusion: The study highlights the necessity of early detection of CRE. Carba NP test assists in the rapid identification of carbapenemase production. However, the genotypic test remains the gold standard for detection of CRE. [ABSTRACT FROM AUTHOR]

Pork production is a niche economy in Egypt, and pigs are typically raised as backyard animals with no sanitary control, potentially exposing them to various pathogens. Commercially available ELISAs were used to detect specific antibodies to the food-borne zoonotic parasites Toxoplasma gondii and Trichinella spp., as well as to Neospora caninum, in serum samples of pigs slaughtered at Egypt’s only licensed pig abattoir, the El-Bassatin abattoir in Cairo. Among the tested sera (n = 332), seroreactivity for T. gondii was 45.8% (95% confidence interval: 40.4–51.3), N. caninum was 28.0% (95% CI: 23.3–33.2), and Trichinella spp. was 1.2% (95% CI: 0.4–3.3). Mixed infection was only detected for T. gondii and N. caninum (18.7%; 95% CI: 14.7–23.4). The seroprevalence of T. gondii was significantly higher (p = 0.0003) in animals collected from southern Cairo (15 May city slum) than in eastern Cairo (Ezbet El Nakhl slum). Seroprevalence for N. caninum was higher in western (Manshiyat Naser slum; p = 0.0003) and southern Cairo (15 May city slum; p = 0.0003) than in that of eastern Cairo (Ezbet El Nakhl slum; p = 0.0003). Moreover, female pigs exhibited a higher rate of N. caninum antibodies than male ones (p < 0.0001). This study provides the first seroprevalence data for N. caninum in pigs in Egypt, and updates the prevalence of the zoonotic parasites Trichinella spp. and T. gondii.

Sarcocystosis considerably occurs in a wide host range including animals, reptiles, humans, and birds. This study was conducted to determine the prevalence of Sarcocystis spp. using abattoir inspection, genetic characterization, as well as histopathology in water buffaloes in two provinces, Elbehera and Kafrelsheikh, Egypt. Specimens were collected from esophagus, tongue, and masseters of 400 slaughtered buffaloes in Elbehera (n= 215) and Kafrelsheikh (n= 185). Samples were examined macroscopically and histopathologically. Furthermore, genetic characterization of Sarcocystis spp. was performed using the 18SrRNA gene-based PCR. The total prevalence was 71.0% (75.3% and 65.9% in Elbehera and Kafrelsheikh, respectively). Aged buffaloes had a higher prevalence than young ones. Females had a higher prevalence than males. The esophagus was the most infected organ. Molecular analysis revealed that the recovered species was S. fusiformis. This is the first genetic characterization of S. fusiformis in water buffaloes from Elbehera and Kafrelsheikh, Egypt. Higher prevalence proposed the potential role of cats in the transmission of S. fusiformis, which, in turn, requires strict hygienic measures to protect animals and humans from infection.

Background: Throughout the history of the city, the architecture of Alexandria, Egypt, has been in contact with world cultures, especially those of the Mediterranean sphere. Alexandria is rich with cultural features dating back seven thousand years. In Alexandria, the heritage value of the city has decreased because there is no suitable documentation system for these more recent assets. The development of a new technique for preserving heritage buildings is required. For example, image- based techniques can gather data using photography, panoramic photography, and close-range photogrammetry. In this research, we primarily seek to implement Heritage Digitisation Process Phases (HDPP) and establish new documentation methods in architectural conservation and built-heritage preservation, i.e., Virtual Reality (VR) and Website Heritage Documentation (WHD). Methods: The methodology is designed to preserve and manage cultural heritage using HDPP for the promotion of heritage building preservation in Alexandria. Results: The results show that the application of HDPP has led to the creation of a digital database about the Société Immobilière building, which was chosen as a case study for this research. Conclusions: Implementation of HDPP and usage of new documentation methods i.e., VR and WHD create a digital path to help strengthen its image and connect the place to users, recreational areas are created to communicate and explore the city’s architectural history.