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3. Oral malodor in Special Care Patients: current knowledge

Author

Marini, M. F., Porter, S. R., Ferrario, S., Allocca, G., Menozzi, G., Grossi, GIOVANNI BATTISTA, and Zanette, Gastone

Subjects
Special Care Dentistry, Disability, Halitosis, Oral Hygiene, Halitosis, Special Care Dentistry, Disability, Oral Hygiene
Published
2018

4. The first meeting of the European Register of Cystic Echinococcosis (ERCE)

Author

Rossi, P., Tamarozzi, F., Galati, F., Pozio, E., Akhan, O., Cretu, C. M., Vutova, K., Siles-Lucas, M., Brunetti, E., Casulli, A., Abela-Ridder, B., Al-Jawabreh, A., Angheben, A., Belhassen Garcia, M., Borys, S., Bruschi, F., Calleri, G., Chianura, L. G., Dezsenyi, B., Harandi, M. F., Giordani, M. T., Gjoni, V., Gogichaishvili, L., Goletti, D., Lapini, E., Karim, F., Mastrandrea, S., Menozzi, G., Muhtarov, M., Ramharter, M., Recordare, A., Shkjezi, R., Teggi, A., Torti, C., Vitale, G., Wallon, M., Zammarchi, L., HERACLES extended network, and European Commission

Subjects
0301 basic medicine, Register (sociolinguistics), Societies, Scientific, medicine.medical_specialty, Veterinary medicine, Databases, Factual, Public health awareness, 030231 tropical medicine, Context (language use), Meeting Report, European Register, 03 medical and health sciences, 0302 clinical medicine, case series, clinical management, cystic echinococcosis, european register, public health awareness, surveillance, databases, factual, echinococcosis, europe, humans, public health, societies, scientific, disease notification, registries, Echinococcosis, Medicine, Humans, Registries, Case series, Disease Notification, Surveillance, business.industry, Clinical management, Public health, medicine.disease, 3. Good health, Eastern european, Europe, Cystic echinococcosis, 030104 developmental biology, Infectious Diseases, Family medicine, Parasitic disease, Observational study, Parasitology, Public Health, business
Abstract

6 páginas, 3 figuras, 1 tabla, Cystic echinococcosis (CE) is a zoonotic parasitic disease endemic in southern and eastern European countries. The true prevalence of CE is difficult to estimate due to the high proportion of asymptomatic carriers who never seek medical attention and to the underreporting of diagnosed cases, factors which contribute to its neglected status. In an attempt to improve this situation, the European Register of Cystic Echinococcosis (ERCE), was launched in October 2014 in the context of the HERACLES project. ERCE is a prospective, observational, multicentre register of patients with probable or confirmed CE. The first ERCE meeting was held in November 2015 at the Italian National Institute of Health (Istituto Superiore di Sanita, ISS) in Rome, to bring together CE experts currently involved in the Register activities, to share and discuss experiences, and future developments. Although the Register is still in its infancy, data collected at the time of writing this report, had outnumbered the total of national cases reported by the European endemic countries and published by the European Centre for Disease Prevention and Control in 2015. This confirms the need for an improved reporting system of CE at the European level. The collection of standardized clinical data and samples is expected to support a more rational, stage-specific approach to clinical management, and to help public authorities harmonize reporting of CE. A better understanding of CE burden in Europe will encourage the planning and implementation of public health policies toward its control., This research received funding from the European Community’s Seventh Framework Programme under the grant agreement 602051 (Project HERACLES: Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies; http:// www.heracles-fp7.eu/).

Published
2016

9. The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations

Author

Piscaglia, F, Bolondi, L, Italian Society for Ultrasound in Medicine, Aiani, Biology Study Group on Ultrasound Contrast Agents 1 L., Luigi Angeli, M., Arienti, V., Barozzi, L., Basilico, R., Bertolotto, M., Biasini, E., Busilacchi, P., Calliada, F., Caremani, * M., Caturelli, E., Celli, N., Colecchia, A., Cova, L., Assunta Cova, M., Crocetti, L., de Sio, I., Drudi, Francesco Maria, Ferraioli, G., Filice, C., Fornari, F., Gaiani, S., Giangregorio, F., Giorgio, A., Ierace, T., Lencioni, R., Livraghi, T., Magnolfi, F., Martegani, A., Meloni, F., Menozzi, G., Pelosi, G., Pompili, M., Riccardi, L., Ricci, P., Rubaltelli, L., Sacerdoti, D., Serafini, G., Serra, C., Solbiati, L., Tacconi, D., Valentino, M., Vidili, G., Vitali, F., Piscaglia F., Bolondi L., and Italian Society for Ultrasound in Medicine and Biology (SIUMB) Study Group on Ultrasound Contrast Agents.

Subjects
medicine.medical_specialty, Acoustics and Ultrasonics, Sulfur Hexafluoride, Biophysics, Contrast Media, Abdomen, medicine, Retrospective analysis, Adverse Drug Reaction Reporting Systems, Humans, Radiology, Nuclear Medicine and imaging, Adverse effect, Phospholipids, Retrospective Studies, Ultrasonography, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Incidence (epidemiology), Magnetic resonance imaging, Retrospective cohort study, Safety profile, medicine.anatomical_structure, Liver, Abdominal examination, Radiology, business
Abstract

The aim of the present retrospective study was to assess the incidence of adverse events (AE) of a second-generation ultrasound contrast agent in real clinical practice. A total of 28 Italian Centres provided data on the postmarketing use of SonoVue (Bracco Spa, Milan, Italy) in abdominal examination performed between December 2001 and December 2004. A total of 23 188 investigations were reported. No fatal event occurred. AEs were reported in 29 cases, of which only two were graded as serious; the rest, 27, were nonserious (23 mild, three moderate and one severe). The overall reporting rate of serious AE was 0.0086%. Overall, only four AEs required treatment (two serious, two nonserious including one moderate and one severe AEs). In conclusion, the present large-scale retrospective analysis showed that SonoVue has a good safety profile in abdominal applications, with an AE reporting rate lower than or similar to that reported for radiologic and magnetic resonance contrast agents.

Published
2006

11. Ethyl or methyl 6-substituted 3-(benzoylamino)-2-oxo-2H-pyran-5-carboxylates and 3-(benzoylamino)-7,8-dihydro-2H-1-benzopyran-2,5(6H)-diones with local anesthetic, platelet antiaggregating and other activities

Author

Mosti, L., Menozzi, G., Schenone, P., michele d'amico, Falciani, M., Rossi, F., Mosti, L, Menozzi, G, Schenone, P, D'Amico, Michele, Falciani, M, and Rossi, Francesco

Subjects
Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, Anti-Inflammatory Agents, Non-Steroidal, In Vitro Techniques, Carrageenan, Rats, Mice, Coumarins, Pyrones, Animals, Edema, Humans, Spectrophotometry, Ultraviolet, Anesthetics, Local, Anti-Arrhythmia Agents, Platelet Aggregation Inhibitors, Pain Measurement
Abstract

The synthesis of ethyl or methyl 6-substituted 3-(benzoylamino)-2-oxo-2H-pyran-5-carboxylates 2 and 3-(benzoylamino)-7,8-dihydro-2H-1-benzopyran-2,5(6H)-diones 4 by reaction of hippuric acid in acetic anhydride with ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates and 2-dimethylaminomethylene-1,3-cyclohexanediones, respectively, is described. Some compounds 2 and 4 showed a strong local anesthetic activity in mice and a platelet antiaggregating activity in vitro comparable to that of acetylsalicylic acid, as well as moderate analgesic, antiinflammatory and antiarrhythmic activities in rats and mice.

Published
1994

12. 1-Aryl-1H-pyrazole-5-acetic acids with antiinflammatory, analgesic and other activities

Author

Menozzi, G., Mosti, L., Schenone, P., michele d'amico, Falciani, M., Filippelli, W., Menozzi, G, Mosti, L, Schenone, P, D'Amico, Michele, Falciani, M, and Filippelli, W.

Subjects
Magnetic Resonance Spectroscopy, Fever, Platelet Aggregation, Spectrophotometry, Infrared, Anti-Inflammatory Agents, Non-Steroidal, Acetates, In Vitro Techniques, Carrageenan, Rats, Mice, Animals, Edema, Humans, Pyrazoles, Collagen, Platelet Aggregation Inhibitors, Pain Measurement
Abstract

Reaction of methyl 4-methoxy-2-dimethylaminomethylene-3-oxobutanoate with arylhydrazines gave methyl 1-aryl-5-(methoxymethyl)-1H-pyrazole-4-carboxylates 1 in high yields. Esters 1 were hydrolyzed to the relative carboxylic acids, which were converted by heating to 1-aryl-5-(methoxymethyl)-1H-pyrazoles 3 in good yields. Reaction of 3 with hydrobromic acid afforded the intermediate 1-aryl-5-(bromomethyl)-1H-pyrazoles, which were converted with potassium cyanide to 1-aryl-1H-pyrazole-5- acetonitriles, whose hydrolysis gave the required 1-aryl-1H-pyrazole-5-acetic acids. Some acids 5 showed a strong antiinflammatory and analgesic activity in rats and mice, respectively, as well as moderate antipyretic and in vito platelet antiaggregating effects.

Published
1994

17. 4-substituted 1-methyl-1H-indazoles with analgesic, antiinflammatory and antipyretic activities

Author

Mosti, L., Menozzi, G., Fossa, P., Schenone, P., Lampa, E., Parrillo, C., michele d'amico, Rossi, F., Mosti, L, Menozzi, G, Fossa, P, Schenone, P, Lampa, E, Parrillo, C, D'Amico, Michele, and Rossi, Francesco

Subjects
Mice, Indazoles, 4-Substituted 1-methyl-1H-indazoles, Anti-Inflammatory Agents, Non-Steroidal, Animals, Humans, Blood Pressure, In Vitro Techniques, Antihypertensive Agents, Platelet Aggregation Inhibitors, Rats
Abstract

The synthesis of [(1-methyl-1H-indazol-4-yl)oxy]acetic acid 4, 1-methyl-1H-indazole-4-acetic acid 9, 2-(1-methyl-1H-indazol-4-yl)propanoic acid 15 and [[(1,5,6,7-tetrahydro-1-methyl-4H-indazol-4-ylidene)amino]oxy]acet ic acid 16, as well as of amides and esters derived from 4 and 9, starting from 1,5,6,7-tetrahydro-1-methyl-4H-indazol-4-one is described. Some of the above compounds showed weak antiinflammatory, analgesic, antipyretic and hypotensive activities in rats and mice, as well as moderate platelet antiaggregating effects in vitro.

Published
1992

25. The effect of menopause on blood lipid and lipoprotein levels

Author

de aloysio, D, Gambacciani, M, Meschia, M, Pansini, F, Bacchi Modena, A, Bolis, Pf, Massobrio, M, Maiocchi, G, Peruzzi, E, Nencioni, T, Ciammella, M, Bonaccorsi, G, Morano, D, Viglino, S, Artoni, G, Grassini, E, Radici, G, De Cicco, F, Ronsisvalle, E, Marcacci, B, Perrone, P, De PAoli, D, Colacurci, N, De Franciscis, P, Lodico, G, Ferreri, R, Loizzi, V, Giacomelli, P, Benetello, E, Salmaggi, P, Coniglio, E, Giussani, E, Comi, R, Grimaldi, E, Mangino, Fp, Bucciantini, S, Checcucci, V, Nappi, C, Affinito, P, Campagnoli, C, Lanza, M, Galbiati, G, Albini, D, Lentini, G, Civallelci, S, Galbignani, E, Franchi, M, Terreni, Mg, Cicoli, C, Pulisca, S, Chionna, R, Marabini, R, Cordopatri, A, Spadaro, I, Cagnacci, Angelo, Volpe, A, De Leo, V, La MArca, A, Camanni, F, Manieri, C, Scognamiglio, P, Romani, L, Cargiaghe, S, Mannu, L, Masi, P, Fattorini, G, Bersellini, B, Bianicotti, L, Marchesoni, D, Dal Pozzo, M, Ramazzotto, F, Stegher, C, Molteni, B, Molteni, E, Lombardo, R, Galati, G, Sironi, A, Ranchet, G, Belloni, C, Proietti, C, Lorefice, R, Menozzi, G, Carunchio, P, Rovetta, E, Gallo, M, De Luigi, G, Righetti, G, Favaro, P, Gentile, E, Flangini, O, De Stefani, L, Sciacchitano, Sg, Catrini, R, Bartiromo, F, Bruno, M, Puggioni, Gf, Sionis, L, Agostinelli, D, Tajani, E, Mercuri, G, and Petronio, P.

Subjects
Menopause, Lipid, Cholesterol
Published
1999

26. Gene Corrected Spinal Muscular Atrophy-Induced Pluripotent Stem Cells and Motoneuron as a Model and Cell Source for Transplantation (P03.176)

Author

Corti, S., primary, Nizzardo, M., additional, Simone, C., additional, Falcone, M., additional, Nardini, M., additional, Ronchi, D., additional, Donadoni, C., additional, Salani, S., additional, Riboldi, G., additional, Menozzi, G., additional, Bonaglia, C., additional, Magri, F., additional, Bresolin, N., additional, and Comi, G., additional

Published
2012
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27. Gene Corrected Spinal Muscular Atrophy-Induced Pluripotent Stem Cells and Motoneuron as a Model and Cell Source for Transplantation (IN8-2.002)

Author

Corti, S., primary, Nizzardo, M., additional, Simone, C., additional, Falcone, M., additional, Nardini, M., additional, Ronchi, D., additional, Donadoni, C., additional, Salani, S., additional, Riboldi, G., additional, Menozzi, G., additional, Bonaglia, C., additional, Magri, F., additional, Bresolin, N., additional, and Comi, G., additional

Published
2012
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28. P3.15 A model for motor neuron degeneration and treatment of Spinal Muscular Atrophy using human induced pluripotent stem cells

Author

Corti, S., primary, Magri, F., additional, Nizzardo, M., additional, Simone, C., additional, Falcone, M., additional, Salani, S., additional, Donadoni, C., additional, Nardini, M., additional, Riboldi, G., additional, Menozzi, G., additional, Bonaglia, C., additional, Rizzo, F., additional, Bresolin, N., additional, and Comi, G.P., additional

Published
2011
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45. ChemInform Abstract: Reaction of 2‐Dimethylaminomethylene 1,3‐Diones with Dinucleophiles. Part 11. Synthesis, Antiviral (HSV‐1), and Antimycotic Activities of Ethyl or Methyl 2,4‐Disubstituted 5‐Pyrimidinecarboxylates, 2,4‐ Disubstituted 5‐Pyrimidinecarboxylic Acids, and 2,4‐Disubstituted Pyrimidines.

Author

SANSEBASTIANO, L., primary, MOSTI, L., additional, MENOZZI, G., additional, SCHENONE, P., additional, MURATORE, O., additional, PETTA, A., additional, DEBBIA, E., additional, SCHITO, A. P., additional, and SCHITO, G. C., additional

Published
1994
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48. Synthesis and 3D QSAR of New Pyrazolo[3,4-b]pyridines:  Potent and Selective Inhibitors of A<INF>1</INF> Adenosine Receptors

Author

Manetti, F., Schenone, S., Bondavalli, F., Brullo, C., Bruno, O., Ranise, A., Mosti, L., Menozzi, G., Fossa, P., Trincavelli, M. L., Martini, C., Martinelli, A., Tintori, C., and Botta, M.

Abstract

A number of 4-aminopyrazolo[3,4-b]pyridines 5-carboxylic acid esters (2−8) were synthesized and evaluated for their binding affinity at the A1, A2A, and A3 adenosine receptors (AR), in bovine cortical membranes, as well as for their affinity toward human A1AR (hA1AR). Some of the new compounds were characterized by a high affinity and selectivity toward the A1 receptor subtype, showing a significant improvement in comparison with other pyrazolo-pyridines previously reported in the literature. In particular the methyl ester 2h as well as the isopropyl ester 5h, both of them bearing a p-methoxyphenylethylamino side chain at the position 4, presented Ki values of 6 and 7 nM, respectively. To rationalize the relationships between structure and affinity of the novel compounds, a 3D QSAR model was also generated starting from compounds belonging to different classes of known A1AR antagonists.

Published
2005

49. Structure-Based Design, Parallel Synthesis, Structure−Activity Relationship, and Molecular Modeling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives

Author

Ranise, A., Spallarossa, A., Cesarini, S., Bondavalli, F., Schenone, S., Bruno, O., Menozzi, G., Fossa, P., Mosti, L., Colla, M. La, Sanna, G., Murreddu, M., Collu, G., Busonera, B., Marongiu, M. E., Pani, A., Colla, P. La, and Loddo, R.

Abstract

In this paper we describe our structure-based ligand design, synthetic strategy, and structure−activity relationship (SAR) studies that led to the identification of thiocarbamates (TCs), a novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs), isosteres of phenethylthiazolylthiourea (PETT) derivatives. Assuming as a lead compound O-[2-(phthalimido)ethyl]phenylthiocarbamate 12, one of the precursors of the previously described acylthiocarbamates (Ranise, A.; et al. J. Med. Chem. 2003, 46, 768−781), two targeted solution-phase TC libraries were prepared by parallel synthesis. The lead optimization strategy led to para-substituted TCs 31, 33, 34, 39, 40, 41, 44, 45, and 50, which were active against wild-type HIV-1 in MT-4-based assays at nanomolar concentrations (EC50 range:  0.04−0.01 μM). The most potent congener 50 (EC50 = 0.01 μM) bears a methyl group at position 4 of the phthalimide moiety and a nitro group at the para position of the N-phenyl ring. Most of the TCs showed good selectivity indices, since no cytotoxic effect was detected at concentrations as high as 100 μM. TCs 31, 37, 39, 40, and 44 significantly reduced the multiplication of the Y181C mutant, but they were inactive against K103R and K103N + Y181C mutants. Nevertheless, the fold increase in resistance of 41 was not greater than that of efavirenz against the K103R mutant in enzyme assays. The docking model predictions were consistent with in vitro biological assays of the anti-HIV-1 activity of the TCs and related compounds synthesized.

Published
2005

50. Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells

Author

Carraro, F., Pucci, A., Naldini, A., Schenone, S., Bruno, O., Ranise, A., Bondavalli, F., Brullo, C., Fossa, P., Menozzi, G., Mosti, L., Manetti, F., and Botta, M.

Abstract

Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (better than the reference compound) of Src phosphorylation of the breast cancer cells 8701-BC, known to overexpress Src. The ability of such compounds to significantly reduce 8701-BC cell proliferation suggests that this scaffold could be a promising lead for the development of antitumoral agents able to block Src phosphorylation of breast cancer cells.

Published
2004

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