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ObjectiveTo investigate the neuromuscular activity characteristics of Tai Chi athletes and identify optimal muscle synergy patterns.MethodData were collected from 12 elite Tai Chi athletes using a Vicon motion capture system, a Kistler 3D force plate, and a Noraxon surface electromyography system. Muscle synergy patterns were extracted using Non-negative Matrix Factorization.ResultsFour muscle synergy patterns were identified in each of the three phases of the leg stirrup movement, with the optimal synergy pattern for each phase determined as follows: knee lift phase: rectus femoris and vastus lateralis of the right leg; extension phase: rectus femoris, vastus lateralis, biceps femoris, and medial gastrocnemius of the right leg; recovery phase: rectus femoris, vastus lateralis, and medial gastrocnemius of the right leg. These patterns explain the muscle coordination activities for each phase.ConclusionThis study identified the optimal muscle synergy patterns for each phase, supporting the fluidity and force generation of the leg stirrup movement. This provides Tai Chi athletes with a more efficient way to exert strength and maintain balance.

ObjectiveTo explore the biomechanical factors affecting the stability of athletes in the 143D balance phase of competitive Tai Chi.MethodThe Vicon 3D motion capture system, Kistler 3D force platform, and Noraxon surface electromyography (sEMG) system were used to measure the joint angle, joint moment, center of gravity, ground reaction force, and sEMG data of athletes. The stability index was then calculated according to the formula. Pearson’s or Spearman’s correlation tests were used to analyze the associations between the biomechanical factors and stability index.Results(1) Medial lateral stability index (MLSI): A significant negative correlation was found between the ankle inversion angle of the supporting leg (SL) and MLSI (p < 0.05). (2) Anterior posterior stability index (APSI): Significant negative correlations were observed between the ankle intorsion angle, integrated electromyography (iEMG) of the gastrocnemius, and muscle contribution rates of the tibialis anterior, external oblique, and gastrocnemius of the non-supporting leg (NL) with the APSI (p < 0.05). The ankle dorsiflexion moment, iEMG of the rectus femoris and tibialis anterior, muscle contribution rate of the biceps femoris, and root mean-squared (RMS) amplitude of the gluteus maximus of the SL also showed significant negative correlations with the APSI (p < 0.05). Strong and significant negative correlations were also identified between the hip intorsion angle, iEMG of the tibialis anterior, and RMS amplitude of the rectus femoris of the NL with the APSI (p < 0.01). Further strong and significant negative correlation was also found between the RMS amplitude of the biceps femoris of the SL and APSI (p < 0.01). The knee extorsion angle of the NL was positively correlated with the APSI (p < 0.05). (3) Dynamic postural stability index (DPSI): The knee adduction angle, iEMG of the tibialis anterior, and RMS amplitude of the erector spinae of the NL were significantly positively correlated with the DPSI (p < 0.05). The knee abduction and hip extension moments of the SL were also significantly positively correlated with the DPSI (p < 0.05).ConclusionThe ankle inversion angle of the SL impacts left–right stability, while the NL’s hip and ankle intorsion angles, knee extorsion angle, and exertion on the core muscle and SL’s main muscles, as well as exertion of specific muscles of the NL affect anterior–posterior stability. The hip extension and knee abduction moments of the SL, knee adduction angle, exertion on the tibialis anterior, and activation of the erector spinae of the NL significantly affect the overall stability of an athlete.

Fluid analysis of continental shale layers plays a crucial role in evaluating shale oil layer selection. Given the current state of technologies of fluid characterization for continental shale layers and well-site requirements, a rapid method for testing water content of rock sample was developed in this study which uses microwave and is ideal for well site. After removing drilling fluid from the core surface, rock samples are promptly collected and crushed into particles using a mill. These granular samples are then placed in the sample cups of a microwave water content tester. Within 2 seconds, mass percentage data for the rock water sample can be obtained, with an average absolute error of ±0.15%. Initial application studies demonstrate promising prospects for moisture detection data in rock samples. Firstly, the water detection results can be used to calculate the pore space occupied by water in the sample's pore system, enabling quick determination of the sample's apparent porosity when combined with well site pyrolysis data. Secondly, the apparent oil saturation and apparent water saturation of core samples can be calculated based on rock sample density and pyrolysis data, facilitating rapid evaluation of rock sample fluids at the well site. This method eliminates the washing and drying processes for rock samples, reduces analysis time, and consequently enhanced the experimental techniques for core porosity and fluid analysis at well sites.

High-quality lacustrine shale beds within the Paleogene Hetaoyuan Formation in the Biyang Sag, Nanxiang Basin, exhibit significant potential for shale oil resources. Previous studies on the oil-bearing potential and hydrocarbon occurrence of shales in the Biyang Sag were relatively limited, potentially hindering advancements for shale oil exploration. This study focuses on the shales found in the third sub-member of the third member within the Hetaoyuan Formation in well Y1, which locates in the southern area of the Biyang Sag. Through various geochemical analyses such as Rock-Eval pyrolysis, multi-temperature pyrolysis and X-ray diffraction, this research systematically investigates the shale oil contents, hydrocarbon occurrence characteristics, and influencing factors. These results indicate that the lithofacies assemblages of the shale primarily consist of felsic shale facies, dolomitic shale facies and mixed shale facies, with a well-developed laminar structure. The source rock quality is classified as good to excellent, and the thermal maturity stage of oil window. The predominant organic maceral is sapropelic, with organic matter types ranging from Ⅰ to Ⅱ1. Oil content increases with burial depth, ranged from adsorbed hydrocarbons in the upper section to free hydrocarbons in the lower section. Detrital mineral content and total organic carbon (TOC) content are identified as the main factors influencing free and adsorbed hydrocarbon content, respectively. Overall, the oil saturation index (OSI) of the shale in the lower section of the Hetaoyuan Formation exceeds 100 mg/g, with an average free hydrocarbon content over 3 mg/g, indicating promising prospects for shale oil exploration and development.

The corrosion resistance of laser powder bed fusion (LPBF) 304L stainless steel (SS) in 3.5 wt% NaCl solution was evaluated at room temperature through potentiodynamic polarization and electrochemical impedance spectroscopy tests. For electropolished samples, annealing at 1200 °C slightly enhanced the corrosion resistance due to changes in crystal orientation and inclusion composition, and reduced residual strain. In contrast, annealing at 1050 °C significantly reduced the corrosion resistance mainly due to the disappearance of dislocation cells and the remained residual dislocations. Residual stress/strain and martensitic transformation induced by sandpaper grinding can also deteriorate the corrosion resistance. Only the as-received sample shows stable passivation regardless of the surface conditions.

The indoor thermal environment has a direct impact on human thermal comfort and health. In order to assess the status of the indoor thermal environment of typical sports buildings in hot summer and cold winter climate zones in China, 14 badminton halls in 10 cities in Hubei Province (including 5 venues in Wuhan) in this climate zone are chosen as research objects for field testing of indoor thermal environment parameters in 4 seasons. All the tested stadiums are naturally ventilated in non-event conditions. The results reveal that the average indoor temperature of badminton halls in summer is excessively high (i.e., 31.89 °C), which is higher than the regulation specified in JGJ31-2003 or GB-T18883-2022 on the reference interval of the indoor air temperature of venues in summer, (i.e., (26–28 °C) or (22–28 °C), respectively). The average indoor temperature of badminton halls in winter is too low (i.e., 12.95 °C), and it is lower than the recommendations of JGJ31-2003 or GB-T18883-2022 on the reference interval of the indoor air temperature of venues in winter (i.e., (16–18 °C) or (16–24 °C), respectively), relative humidity and air velocity are in the thermal comfort interval for all seasons, and the indoor thermal environment factors of badminton courts in spring and autumn meet the comfort requirements. The indoor and outdoor temperatures and the relative humidity of badminton courts are highly correlated. The indoor temperature and relative humidity vary according to changes in those factors outdoors, whereas the air velocity is not affected by outdoor changes. In the hot summer and cold winter climate zones, some discrepancies in the indoor temperature variation patterns of badminton halls at various altitudes are detectable. The results of this study aim to provide a solid basis for the development of indoor thermal-comfort standards for sports stadiums in China.

Objective: The purpose of this study is to analyze the inherent relationship between the score values and the biomechanical characteristics of the forward kicking motion, we aim to identify the fundamental variables influencing the score values of the forward kicking motion and establish the key biomechanical factors that effectively trigger scoring in the forward kicking motion.Methods: The DaeDo electronic scoring system was used with the Vicon optical motion capture system and the Kistler 3D force platform to obtain kinematic and kinetic variables of the front roundhouse kick motion. Linear bivariate correlation analysis and principal component analysis were used to analyze the associations between kinematic, kinetic variables, and scoring values, and summarize key biomechanical factors for effectively scoring.Results: The peak ankle plantar flexion angle and knee extension torque of the kicking leg showed a significant negative correlation with scoring values (r < 0, p < 0.05), while other variables showed no statistical significance. The peak knee flexion angle and hip extension angular velocity of the supporting leg showed a significant positive correlation with scoring values (r > 0, p < 0.01), while the peak ankle plantar flexion torque showed a significant negative correlation with scoring values (r < 0, p < 0.05), and other variables showed no statistically significant correlation. The absolute values of eigenvectors of the first and second principal components, which included hip angular velocity, ankle angle, knee torque, and hip torque, were relatively large, indicating their strong influence on effective scoring triggering.Conclusion: Maintaining ankle dorsiflexion and a larger knee flexion angle in the kicking leg is favorable for triggering scoring. Higher knee flexion angle and hip extension angular velocity in the supporting leg are also advantageous for triggering scoring. “Body posture” and “Strength” are key factors that effectively trigger scoring.

Abstract The indoor air quality has a direct impact on human health. In order to obtain the current status of indoor air quality in typical sports buildings in hot summer and cold winter climate zones in China, indoor badminton courts in 10 cities in Hubei Province in this climate zone were selected as research objects for field testing of indoor environmental parameters in spring and autumn, and predict air quality parameters for non-testing times. All the tested stadiums are naturally ventilated in non-event conditions, and the average daily indoor CO2 concentration was 526.78 ppm in spring and 527.63 ppm in autumn, and the average daily PM2.5 concentration was 0.035 mg/m3 in spring and 0.024 mg/m3 in autumn, all of which met the requirements of GB/T 18883-2022, the average concentration of CO2 ≤ 1000 ppm and PM2.5 ≤ 0.05 mg/m3. The indoor CO2 concentration and PM2.5 concentration of the tested badminton halls under natural ventilation gradually increased with the accumulation of exercise time, making the indoor air quality of the badminton halls decrease, which would negatively affect the health of the people exercising in this environment.

Fluid analysis of continental shale formations is an important basis for the evaluation of shale oil sweet spots. In view of the characteristics that gaseous hydrocarbons in core samples are easy to lose and the needs of shale oil drilling site, a device and method for rapid collection and determination of gaseous hydrocarbons in cores at well site are developed, and a rapid method for calculating apparent gas-oil ratio (AGOR) and estimating free oil loss based on gaseous hydrocarbon analysis and pyrolysis oil content analysis data of cores is discussed. The research shows that the device is suitable for the detection of gaseous hydrocarbons in full-diameter cores and bulk samples. It can not only realize the collection and determination of gaseous hydrocarbons in full-diameter cores at normal temperature and pressure, but also determine the total amount of gaseous hydrocarbons in bulk core samples. The relative error of gaseous hydrocarbon determination is 10%, and the test results can be converted into gaseous hydrocarbon content per unit mass of rock samples. The full-diameter core escape gas analysis can realize the non-destructive collection and determination of gaseous hydrocarbons in the cores, which reflects the change characteristics of vertical oil and gas bearing and heterogeneity of shale formations. AGOR can reflect the trend of oil-gas bearing and flowability of shale formations, and the higher AGOR, the better the flowability of shale oil of corresponding shale formations. AGOR can be used to estimate the loss of free hydrocarbon in the process of pressure and temperature reduction degassing, which has great application potential in establishing the recovery method of the loss of free hydrocarbon in the process of core temperature and pressure reduction degas-sing. The core gas hydrocarbon determination technology enriches the experimental technical means and methods of core fluid analysis suitable for well sites, and provides data support for fluid evaluation and sweet spot determination of continental shale formations.

The third member of Oligocene Hetaoyuan Formation (Eh3) in Biyang Sag of Nanxiang Basin is the first strata in which a breakthrough for continental shale oil exploration is made, but scale development has not been realized due to a variety of factors. In order to reveal the target zone of shale oil exploration and development of the third member of Hetaoyuan Formation in the central deep sag zone of Biyang Sag, a case study on the cored interval of the Ⅲ submember of the third member of Hetaoyuan Formation (Eh33) from shale oil risk exploration well YYY1 is carried out. Systematic studies on the lithofacies types and the characteristics of shale oil enrichment intervals of the cored interval of Eh33 are carried out and the shale oil enrichment pattern and preferred target layers of shale oil exploration and development are defined by taking full advantage of the results of field analysis and combining with previous research results. The findings have shown that seven lithofacies types, i.e. organic laminar mixed shale, organic-rich laminar mixed shale, organic laminar felsic shale, organic-rich laminar felsic shale, organic layered felsic shale and organic massive argillaceous siltstone/siltstone, organic massive fine sandstone, are developed in the middle-lower interval of Eh33 of well YYY1. Eight shale oil enrichment intervals are identified according to two key parameters of free hydrocarbon (S1) and oil saturation index (OSI) and combining with the total porosity of nuclear magnetic logging. The thickness of a single shale oil enrichment interval is 5-20 m and the total thickness is 81 m. The shale oil enrichment intervals developed in the middle interval of Eh33 are all controlled by both in-situ retention hydrocarbon and migration hydrocarbon from the adjacent high TOC layer, with two enrichment patterns: source-reservoir integration and source-reservoir coexistence. The shale oil enrichment intervals developed in the lower interval of Eh33 are all controlled by in-situ retention hydrocarbon, with source-reservoir integration enrichment pattern. The shale oil enrichment interval in the middle interval is defined the preferred target interval for shale oil exploration and development in Eh33 in the central deep sag zone of Biyang Sag. This provides an important basis for shale oil exploration and development in Biyang Sag.

Objective: To explore the inherent relationship between lower limb biomechanical indicators and effective scoring values of double roundhouse kick (DRK) by taekwondo athletes, and to find key biomechanical factors that trigger effective scoring.Methods: Using the DAEDO Protector and Scoring System (PSS) in conjunction with the Vicon optical motion capture system and Kistler 3D force plate, kinematic and dynamic indicators of the front kicking motion were obtained from 12 professional taekwondo athletes (18.00 ± 2.20 years, 182.15 ± 8.62 cm and 70.00 ± 14.82 kg). The correlation between kinematics, dynamics, and scoring values was initially analyzed using bivariate linear correlation. Subsequently, based on the results of the linear correlation analysis, a stepwise regression analysis was performed to establish a stepwise regression equation.Results: The results reveal that during the First Hit, there is a significant positive correlation (r > 0, p < 0.05) between peak hip flexion angular velocity of the dominant leg, knee abduction angle, and peak foot horizontal plane linear velocity of the non-dominant leg with effective score. On the other hand, peak ankle flexion angular velocity of the non-dominant leg, peak foot sagittal plane linear velocity, peak hip abduction angle, and peak hip flexion angle of the dominant leg exhibit a significant negative correlation (r < 0, p < 0.05) with effective score. These correlations hold statistical significance (DW> 1.023). During the Second Hit, there is a significant positive correlation (r > 0, p < 0.05) between peak ankle internal rotation angular velocity of the dominant leg, foot coronal plane linear velocity, hip adduction angular velocity, and peak ankle internal rotation moment of the non-dominant leg with effective score. Conversely, peak hip flexion angle of the dominant leg shows a significant negative correlation (r < 0, p < 0.05) with effective score. All these variables have a statistically significant impact on effective score (DW > 1.023).Conclusion: Explosive power, body posture, adequate terminal velocity, and body rotation have an association with effective scoring of the electronic protector. The peak angular velocity of the ankle joint of the dominant leg and the peak linear velocity of the foot horizontal plane of the non-dominant leg significantly contribute to the effectiveness score of the electronic protector.

Background: The Double Roundhouse Kick (DRK) is one of the major scoring tools and athletes employ the leg of the dominant side (DS) or the non-dominant side (NS) for always attacking in an alternating state. The purpose is to examine the discrepancies in the biomechanical characteristics of the DS and NS of the leg of the DRK skills of sub-elite taekwondo athletes. Methods: Using the Vicon, Kistler, and Daedo brand Electronic Body Protector (EBP), collection of the DRK data (attack time, joint angle, joint angular velocity, joint moment, ground reaction force, etc.) of 12 sub-elite taekwondo athletes (19.6 ± 2.0 yr, 180 ± 7.3 cm, 70 ± 9.8 kg) with the DS leg and NS leg. The measured data analyses via Visual3D, and statistical methods using nonparametric tests paired with samples based on the Wilcoxon signed-rank test (The significance level is set as significant for P0.05) and shift of the center of gravity (P>0.05). (ii) Attacking leg (AL): the maximum knee flexion angle (Knee-MFA) (P

[Objective] The temporal and spatial characteristics of the dominant transformation of cultivated land use in Henan Province was analyzed in order to provide a scientific basis for the rational and optimal allocation and sustainable utilization of cultivated land in the main intensive grain producing areas in the north. [Methods] We interpreted data from five Landsat TM images from 2000 to 2020 to construct contribution degree, range, and speed models of cultivated land use change. Temporal and spatial change characteristics of cultivated land quantity and spatial form were quantitatively described from the dominant perspective. Spatial visualization was carried out with the help of "3S" means. [Results] ① From 2000 to 2020, the quantity and form of cultivated land use transformation in Henan Province experienced a drastic transformation process. The net decrease in cultivated land was 5 609.93 km2, a decrease of 22.78%. ② The change range of cultivated land use transformation in Henan Province was the greatest from 2015 to 2020. ③ The spatial form of cultivated land presented a distribution characteristic of outward diffusion with Zhengzhou City as the center. The greatest change in cultivated land use was observed in Central Henan Province, with the least change in Western Henan Province. Changes in Northern, Southern, and Eastern Henan Province were characterized as moderate. [Conclusion] The spatio-temporal characteristics of the explicit transformation of cultivated land use in Henan Province from 2000 to 2020 had obvious consistent differences. Greater attention must be given to the quantity of cultivated land use transformation and the range of cultivated land use transformation in the Central Henan Province.

Organic matter in depositional environment is the essential material for oil and gas generation. Total organic carbon (TOC) is one of the important parameters for estimating the hydrocarbon generation potential of shale oil and predicting sweet spots. The TOC of the second member of the Funing Formation (Ef2) ranges from 0.25% to 2.30%. TOC is higher in the upper shale and lower in the lower shale of the Funing Formation, showing a significant enrichment difference. However, there have been few reports on the study of the main controlling factors for the differential enrichment of organic matter in Ef2. This study aims to reconstruct the paleoenvironment of lacustrine shale in Ef2. Additionally, this study aims to clarify the influence of the paleoenvironment on the differential enrichment of organic matter in Ef2. For this purpose, systematic mineralogical and geochemical analyses were conducted on 72 samples from a representative well. The results indicate that, based on parameters such as paleoclimate (chemical index of alteration, CIA), paleosalinity (Sr/Ba), paleoredox conditions (Cu/Zn), paleoproductivity (P/Ti), water depth (Rb/K), and terrigenous clastic input (Al, Ti), the paleoenvironment during the deposition of the Ef2 shale clearly exhibited significant changes. During the early stage, the climate was hot and dry, with shallow water, weak chemical weathering, low productivity, and salinity ranging from saline to brackish. In the later stage, the climate became warm and humid, with deeper water, moderate chemical weathering, high productivity, and salinity ranging from brackish to freshwater. There are significant errors in directly using the Sr/Ba index to evaluate the paleosalinity of Ef2 shale. Carbonate minerals and calcium-rich bioclasts may increase the Sr/Ba ratio, and the corrected Sr element content is only 44.29% of the original sample. The enrichment of organic matter is clearly controlled by productivity levels and climatic conditions. The higher the paleoproductivity and the warmer and more humid the climate, the more enriched the organic matter becomes. Fundamental differences in paleoproductivity govern the enrichment of organic matter during the deposition process of the Ef2 shale. The organic matter enrichment pattern in the Ef2 shale represents a typical productivity model.

The lacustrine shale in the Da’anzhai member of Jurassic in the central Sichuan Basin is a key exploration target for shale oil and gas resources in China in the future. This paper presents a detailed study of shale rock types and component characteristics, shale pore types and structural characteristics, and shale pore evolution characteristics under thermal simulation conditions through experimental analyses such as rock thin section and field emission scanning electron microscopy (FE-SEM) observation, conventional physical property test, X-ray diffraction (XRD) analysis, TOC test, liquid nitrogen adsorption (LNA) test, and thermal simulation (pore) experiment. The results show that minerals in the Da’anzhai shale are mainly clay minerals, quartz, and calcite, with a small amount of feldspar, dolomite, and pyrite. In the shale oil reservoirs, there are dominantly inorganic pores (e.g. clay intergranular pores), and relatively few organic pores. The specific surface area ranges from 1.064 m 2 /g to 9.227 m 2 /g, with an average of 4.949 m 2 /g. The pore volume is 0.003–0.016 cm 3 /g, with an average of 0.010 cm 3 /g. Mesopores contribute the most to the total pore volume and total specific surface area. With the increase of thermal simulation temperature, the degree of shale thermal evolution increases, and the shale porosity increases, predominantly, owing to the contribution of organic pores. It is concluded that inorganic pores, especially clay intergranular pores, are the dominant pore type in the Da’anzhai shale oil reservoirs, and the evolution degree, burial time and depth of organic matter can obviously improve the organic pores.

Technical efficiency (TE) and total factor productivity (TFP) are important criteria to ensure the enhancement of the quality and efficiency of state-owned enterprises (SOEs) and function as important indicators to assess the quality of their accomplishments. The purpose of this study is to explore whether the efficiency of SOEs is higher or lower than that of private enterprises. Transcendental logarithmic production function and stochastic frontier analysis (SFA) are used to assess the TE and TFP of listed central SOEs, local SOEs, and private enterprises, the data of which were taken from 2006–2020. The results show that the sampled private enterprises had the highest average TE during the study period, followed by the central and local SOEs. The private enterprises also had the highest average TFP growth rate, followed by the local and central SOEs. The TFP decompositions show that the TE change (TEC) and technical change (TC) indices of the SOEs were lower than those of the private enterprises. The TC, TEC, and scale change (SC) are limiting the TFP growth rates of the SOEs in labor-intensive industries. The SC of the SOEs has changed less than that of private enterprises in the sampled capital-intensive industries. Northern and southern China had the highest rates of TE and TFP growth. Indeed, this paper measures and decomposes TFP, and analyzes the efficiency of SOEs and private enterprises in different industries and regions in an international context.

By substituting Zn1-xMgxO (ZMO) for the conventional CdS buffer layer, the CZTSSe solar cells with the efficiency of 11.2% are obtained herein, which can be attributed to the conduction band regulation in the heterojunction. An appropriate conduction band offset (CBO) value can effectively reduce nonradiative recombination loss of charge carriers at the interface, thereby improving the open-circuit voltage (Voc). Herein, ZMO buffer layer with the optical bandgap ranging from 3.34 to 3.90 eV is applied to enhance the CBO in the heterojunction from 0.14 to 0.72 eV. The ZMO-buffered solar cells exhibit higher Voc and shortcurrent density (Jsc) compared to CdS-buffered cells. The optimal efficiency of 11.2% is obtained in CZTSSe solar cell with the CBO of 0.27 eV, Jsc of 39.0 mA cm-2, fill factor of 69.6%, and Voc of 412 mV. [ABSTRACT FROM AUTHOR]

To reveal the anti-protein aggregation ability of brazilin (Bra), hematoxylin (Hto) and hematein (Hte) under physiological crowding environment, the macromolecular crowding reagent (polyethylene glycol) was used to construct a simulated crowding environment. Then the inhibition mechanisms of these three structurally similar polyphenol compounds on the aggregation behavior of human serum albumin (HSA) were investigated by fluorescence spectroscopy, UV-vis absorption spectroscopy, dynamic light scattering (DLS) and atomic force (AFM) microscope assay. The results showed that they could maintain the stability of the HSA structure, decrease the number of amyloid fibrils and shorten the length of aggregates in crowding environment. Therefore, they inhibited the aggregation process of HSA, and the sequence of the inhibition ability was in the order of Hto>Bra>Hte. Moreover, the presence of crowding reagents could lead to a decrease in the inhibitory activity of these three inhibitors compared to in vitro dilute solution. In conclusion, this study suggested that Hto could be used as a potential protein aggregation inhibitor and a functional food ingredient for the treatment and intervention of amyloid-related diseases.

IntroductionPatients with Primary Sjögren’s syndrome (pSS) are at a higher risk of thyroid disorders than the general population. This retrospective analysis of 202 patients with pSS was conducted to uncover risk factors associated with thyroid involvement and to create a predictive model for this condition.MethodsWe analyzed 202 patients with pSS from Guang’anmen Hospital, China Academy of Chinese Medical Sciences, with 105 cases of thyroid involvement and 97 without. The Least Absolute Shrinkage and Selection Operator method was used to identify key variables for our risk model. These variables were then subjected to multivariate logistic regression to develop the model. The accuracy of the model was assessed through the C-index, receiver operating characteristic curves, calibration plots, and decision curve analysis, with internal validation via bootstrapping.ResultsHigh-sensitivity C-reactive protein (HCRP), pulmonary disease, pharyngeal dryness, forgetfulness, night sweats, hyperuricemia, nasal dryness, anxiety, Ro52, and aspartate aminotransferase (AST) were incorporated into the nomogram. The model showed robust discrimination and calibration abilities. Decision curve analysis indicated the clinical utility of our nomogram in intervening on the probability thresholds of thyroid disease.ConclusionBy integrating HCRP, pulmonary disease, pharyngeal dryness, forgetfulness, night sweats, hyperuricemia, nasal dryness, anxiety, Ro52, and AST, our thyroid risk nomogram can predict the risk of thyroid involvement in patients with pSS, aiding in more informed treatment strategies.

Abstract Background The safety of medication use among older adults is a growing concern, given the aging population. Despite widespread attention, the exploration of medication literacy in older adults, particularly from the perspective of information literacy, is in its nascent stages. Methods This study utilized the existing literature to define medication information literacy (MIL) as a theoretical framework. A two‐round Delphi survey was conducted to identify the essential components of a MIL indicator system for older adults. The analytic hierarchy process (AHP) was then used to assign weights to each indicator. Results The study observed relatively high response rates in both rounds of the questionnaire, which, along with expert authority coefficients (Cr) of 0.86 and 0.89, underscores the credibility and expertise of the panellists. Additionally, Kendall's coefficient of concordance (Kendall's W) ranging from 0.157 to 0.33 (p

Abstract Background The organizational climate that fosters and supports the implementation of evidence is a key factor influencing the effective implementation of evidence-based practice (EBP). Nurses, being the largest group of medical staff, play a crucial role in EBP implementation. The perception of the climate for EBP implementation among nurses in their organizations is unknown, especially among Chinese nurses. Aims To clarify the implementation climate of EBP among Chinese nurses and identify the factors associated with the implementation and development of evidence-based nursing practices. Methods This study employed a descriptive cross-sectional study design. From March 2023 to April 2023, a sample of nurses (n = 1260) from two Tertiary care hospitals in central China were selected and surveyed by self-designed social-demographic questionnaire and Implementation Climate Scale. Multiple linear stepwise regression analysis was conducted to determine the predictors of implementation climate. Results The nurses achieved a mean ICS score of 59.10 ± 11.22, with mean scores exceeding 3 points for each sub-dimension and item. In the results of multiple linear regression, income satisfaction, implementation of evidence-based nursing practice project(s) within the unit, experience of evidence-based nursing practice during working life, and specific training or courses in evidence-based nursing practice were predictors of ICS. Of these, income satisfaction was the most significant predictor. These factors could explain 17.5% of the total variance in implementation climate. Conclusion The climate for implementing EBP in Chinese nursing organizations was relatively strong. Nursing managers can enhance the climate for implementing EBP in their organizations by actively improving salary and enhancing EBP-related trainings and practices. Relevance to clinical practice Understanding nurses’ perceptions of the EBP implementation climate in their organizations can help to identify specific barriers and facilitators to the development of EBP and facilitate its successful implementation. Patient or public contribution Clinical nurses were involved in data collection and completed the questionnaires on EBP implementation climate.

BackgroundFalls had been identified as one of the nursing-sensitive indicators for nursing care in hospitals. With technological progress, health information systems make it possible for health care professionals to manage patient care better. However, there is a dearth of research on health information systems used to manage inpatient falls. ObjectiveThis study aimed to design and implement a novel hospital-based fall risk management information system (FRMIS) to prevent inpatient falls and improve nursing quality. MethodsThis implementation was conducted at a large academic medical center in central China. We established a nurse-led multidisciplinary fall prevention team in January 2016. The hospital’s fall risk management problems were summarized by interviewing fall-related stakeholders, observing fall prevention workflow and post–fall care process, and investigating patients' satisfaction. The FRMIS was developed using an iterative design process, involving collaboration among health care professionals, software developers, and system architects. We used process indicators and outcome indicators to evaluate the implementation effect. ResultsThe FRMIS includes a fall risk assessment platform, a fall risk warning platform, a fall preventive strategies platform, fall incident reporting, and a tracking improvement platform. Since the implementation of the FRMIS, the inpatient fall rate was significantly lower than that before implementation (P

Abstract Background The Normalization MeAsure Development (NoMAD) is a brief quantitative tool based on the Normalization Process Theory (NPT), which can measure the implementation process of new technologies and complex interventions. The aim of our study was to translate and culturally adapt the NoMAD into Chinese, and to evaluate the psychometric properties of the Chinese version of NoMAD. Methods According to the NoMAD translation guideline, we undertook forward translation, backward translation, and compared these translations to get a satisfactory result, then we performed cognitive interviews to achieve cross-culture adaptation. And the psychometric properties of the final version were evaluated among clinical nurses who used the pressure injuries management system via WeChat mini-program at a tertiary hospital in northwestern China. Results A total of 258 nurses were enrolled in our study, and the response rate was 92.1%. The Cronbach’s alpha of four dimensions were as follow: Coherence (0.768), Cognitive Participation (0.904), Collective Action (0.820), and Reflexive Monitoring (0.808). The overall internal consistency was 0.941. The confirmatory factor analysis results showed a good fit for its theoretical structure (CFI = 0.924, TLI = 0.910, RMSEA = 0.0079, SRMSR = 0.046, χ2/df = 2.61). The item-level content validity index ranged from 0.857 to 1, and the scale-level content validity index was 0.95. There were positive correlations between four constructs scores and three general normalization scores. Conclusions The Chinese version of NoMAD is a reliable and valid tool to evaluate the implementation process of innovations.

Escherichia coli cysteine desulfurase (CD), IscS, modifies basal metabolism by transferring sulphur (S) from L-cysteine to numerous cellular pathways, whereas NFS1, a human CD, is active only in the formation of the [Acp]2:[ISD11]2:[NFS1]2 complex. Despite the accumulation of red-coloured IscS in E. coli cells as a result of the deficiency of accessible iron, as revealed in our previous studies, the mechanism of the potential enzymatic reaction remains unclear. In this study, the N-terminus of IscS was fused with the C-terminus of NFS1, which was reported to be almost fully active as IscS and exhibits a pyridoxal 5′-phosphate (PLP) absorption peak at 395 nm. Moreover, SUMO-EH-IscS exhibited significant growth recovery and NADH-dehydrogenase I activity in the iscS mutant cells. Furthermore, through in vitro and in vivo experiments combined with high-performance liquid chromatography and ultra-performance liquid chromatography–tandem mass spectrometry, it was shown that the new absorption peaks of the IscS H104Q, IscS Q183E, IscS K206A, and IscS K206A&C328S variants at 340 and 350 nm may correspond to the enzyme reaction intermediates, Cys-ketimine and Cys-aldimine, respectively. However, after mutation of the conserved active-site residues, additional absorption peaks at 420 and 430 nm were associated with PLP migration in the active-site pocket. Additionally, the corresponding absorption peaks of Cys-quinonoid, Ala-ketimine, and Ala-aldimine intermediates in IscS were 510, 325, and 345 nm, respectively, as determined by site-directed mutagenesis and substrate/product-binding analyses during the CD reaction process. Notably, red IscS formed in vitro by incubating IscS variants (Q183E and K206A) with excess L-alanine and sulphide under aerobic conditions produced an absorption peak similar to the wild-type IscS, at 510 nm. Interestingly, site-directed mutation of IscS with hydrogen bonds to PLP at Asp180 and Gln183 resulted in a loss of enzymatic activity followed by an absorption peak consistent with NFS1 (420 nm). Furthermore, mutations at Asp180 or Lys206 inhibited the reaction of IscS in vitro with L-cysteine (substrate) and L-alanine (product). These results suggest that the conserved active site residues (His104, Asp180, and Gln183) and their hydrogen bond with PLP in the N-terminus of IscS play a key role in determining whether the L-cysteine substrate can enter the active-site pocket and regulate the enzymatic reaction process. Therefore, our findings provide a framework for evaluating the roles of conserved active-site residues, motifs, and domains in CDs.

Early Cretaceous A-type granites are widespread in the Shandong Peninsula, which can be used to elucidate the tectonic evolution of the eastern China and the destruction of the North China Craton. However, their genesis is still controversial. Several competing models, ranging from slab break-off, postorogenic extension, foundering of the lower crust and ridge subduction, were proposed. Here, we report zircon U–Pb ages, whole-rock and apatite geochemical compositions of the Laoshan granite and discuss its tectonic implications. The Laoshan granite has typical characteristics of A-type granite with high FeOT/(FeOT + MgO) ratios (0.90–0.97) and 10000*Ga/Al ratios (2.70–3.36) and high total alkali (Na2O + K2O: 7.95–8.70 wt%) contents and Zr+Nb+Ce+Y (most >350 ppm) concentrations. The Laoshan granite is further classified as A1-type based on the Yb/Ta-Y/Nb and Ce/Nb-Y/Nb diagrams and the Nb-Y-3Ga and Nb-Y-Ce triangular discriminant diagrams. Zircon U–Pb dating of two Laoshan granite samples yielded emplacement ages of 117.8 ± 1.0 Ma and 120.1 ± 1.3 Ma, respectively. The oxygen fugacity of the Laoshan granite magma is low, as indicated by zircon Ce4+/Ce3+ ratios (most

Abstract Aim Pressure injuries are common adverse events in clinical practice, affecting the well‐being of patients and causing considerable financial burden to healthcare systems. It is therefore essential to use reliable assessment tools to identify pressure injuries for early prevention. The Braden Scale is a widely used tool to assess pressure injury risk, but the literature is currently lacking in determining its accuracy. This study aimed to evaluate the accuracy of the Braden Scale in assessing pressure injury risk. Design Systematic review and meta‐analysis. Methods Articles published between 1973–2020 from periodicals indexed in the PubMed, EMBASE, CINAHL, Web of Science and the Cochrane Library were selected. Two reviewers independently selected the relevant studies for inclusion. Data were analysed by the STATA 15.0 and the RevMan 5.3 software. Results In total, 60 studies involving 49,326 individuals were eligible for this meta‐analysis. The pooled SEN, SPE, PLR, NLR, DOR and AUC were 0.78 (95% CI: 0.74 to 0.82), 0.72 (95% CI: 0.66 to 0.78), 2.80 (95% CI: 2.30 to 3.50), 0.30 (95% CI: 0.26 to 0.35), 9.00 (95% CI: 7.00 to 13.00) and 0.82 (95% CI: 0.79 to 0.85), respectively. Subgroup analyses indicated that the AUC was higher for prospective design (0.84, 95% CI: 0.81 to 0.87), mean age

In a marine environment, the working conditions for carbon brush and slip-ring system are complicated, leading to carbon brush abrasion and a shortened replacement cycle. A research and experiment platform using a salt spraying tester has been established to study abrasion on the carbon brush and slip-ring system of a Doubly-fed machine. We conducted tests on the carbon brush and slip-ring system contact current, contact pressure, concentration of salt spray, and the experimental temperature. The improved Coulomb-viscous friction model was adopted for modelling the carbon brush abrasion. The contact current, contact pressure, salt spray concentration and temperature were introduced as the test conditions for the forecast model, and the unknown model parameters were identified through the least square method. MATLAB was utilized to fit the nonlinear model parameters using the carbon brush abrasion prediction model results. The residual error plot and test data fitting indicated that the prediction model could effectively forecast the carbon brush abrasion loss under various conditions.

BackgroundMental health is a public health problem of great concern. Previous studies show that textual features and individual psychological characteristics can influence the effect of receiving information.PurposeThis study explores whether textual features influence the persuasiveness of teenager students’ mental health education while considering the influence of risk preference.MethodsFrom November to December 2021, a cross-sectional study was conducted among 1,869 teenager students in grade 7–12 in Chongqing, China. Wilcoxon signed-rank test, multiple logistic regression, and subgroup analysis were used to analyze the data.ResultsAmong the four textual features mentioned in this study, a significant difference was reported in the persuasive effects of information with and without numerical features (p 0.05). Combined with those from the risk preference analysis, results showed that the regulatory effect of risk preference was only reflected in emotional conflicts. Students who prefer having no emotional conflict in the text showed the characteristics of risk avoidance, or lower grades, or rural or school accommodation. Most teenager students are also risk averse, especially females (or = 2.223, 95%CI:1.755–2.815) and juniors (or = 1.533, 95%CI: 1.198–1.963).ConclusionThe numbers, symbols, and positive emotions in the text generate an active effect on teenager students receiving mental health education. Students avoiding risk are inclined to read texts without emotional conflicts. The probability of male choosing texts with positive emotional polarity is 33.5% lower than that of female. Female students and those from lower grades also demonstrate a higher inclination to risk avoidance compared with their male and higher grade counterparts. Therefore, educational materials with different text characteristics should be developed for teenager students with varying characteristics.

Tachyplesin I is a cationic antimicrobial peptide with 17 amino acids. The long-term continuous exposure to increased concentrations of tachyplesin I induced resistance in Pseudomonas aeruginosa. The global gene expression profiling of tachyplesin I–resistant P. aeruginosa strains PA-60 and PA-99 and the sensitive strain P. aeruginosa CGMCC1.2620 (PA1.2620) were conducted by transcriptome sequencing to analyze the common underlying mechanism of resistance to tachyplesin I in low- or high-resistance mutants. The co-expression patterns, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, sRNA target genes, and single-nucleotide polymorphism (SNP) change were analyzed for the co-expressed genes in this study. A total of 661 differentially co-expressed genes under treatments of PA1.2620 vs. PA-99 and PA1.2620 vs. PA-60 (HL) were divided into 12 kinds of expression patterns. GO and KEGG pathway enrichment analyses indicated that the enrichment of co-expressed genes was mainly associated with oxidoreductase activity, mismatched DNA binding, mismatch repair, RNA degradation of GO terms, aminoacyl-tRNA biosynthesis, and aminobenzoate degradation pathways, and so forth. The co-expressed resistance-related genes were mainly involved in antibiotic efflux and antibiotic inactivation. Seven co-expressed genes had SNP changes. Some co-expressed sRNAs were involved in P. aeruginosa resistance to tachyplesin I by regulating target genes and pathways related to resistance. The common resistance mechanism of P. aeruginosa among different mutants to tachyplesin I was mainly associated with the expression alteration of several genes and sRNA-regulated target genes related to resistance; few genes had base mutations. The findings of this study might provide guidance for understanding the resistance mechanism of P. aeruginosa to tachyplesin I.

Loss of gray-white matter discrimination is the primary early imaging finding within of cranial computed tomography in cardiac arrest survivors, and this has been also regarded as a novel predictor for evaluating neurologic outcome. As displayed clearly on computed tomography and based on sensitivity to hypoxia, the gray-white matter ratio at basal ganglia (GWR-BG) region was frequently detected to assess the neurologic outcome by several studies. The specificity of GWR-BG is 72.4 to 100%, while the sensitivity is significantly different. Herein we review the mechanisms mediating cerebral edema following cardiac arrest, demonstrate the determination procedures with respect to GWR-BG, summarize the related researches regarding GWR-BG in predicting neurologic outcomes within cardiac arrest survivors, and discuss factors associated with predicting the accuracy of this methodology. Finally, we describe the effective measurements to increase the sensitivity of GWR-BG in predicting neurologic outcome.

Objective: To evaluate evidence from published systematic reviews about the effectiveness of exercise interventions on fatigue management in breast cancer patients. Methods: PubMed, Web of Science, the Cochrane Library, the Cumulative Index of Nursing and Allied Health (CINAHL), Embase databases, the China National Knowledge Infrastructure (CNKI), the Wanfang database, the China Biomedical Literature Database (CBM), and the VIP database were searched to identify relevant systematic reviews. The reviews which assessed exercise interventions on cancer-related fatigue (CRF) in breast cancer patients were included. Quality of evidence was evaluated by the Grade of Recommendation, Assessment, Development, and Evaluation (GRADE) tool. The Assessment of Multiple Systematic Reviews (AMSTAR) appraisal tool was used to evaluate the methodological quality of included systematic reviews. Results: Twenty-four systematic reviews met all the inclusion criteria. The overall mean score for AMSATR is 7.38 and ranged from 4 to 10 points. In addition, 21 reviews arrived at positive conclusions, which exercises could reduce CRF, and 3 obtained that exercise does not affect fatigue. As for GRADE, 8 of the reviews were graded as ‘moderate’, 2 of the studies were ‘very low’, and the others were ‘low’. Conclusions: Aerobic and resistance exercise can be regarded as beneficial to CRF in breast cancer patients, and limited evidence exists that yoga had an effect on reducing fatigue. The quality of the current systematic review is still far from satisfactory.

Estrogen-related receptor (ERR) is an orphan nuclear receptor that was first discovered in animals, and play an important role in metabolism, development, and reproduction. Despite extensive research on the function of ERR, its transcriptional regulation mechanism remains unclear. In this study, we obtained the upstream region of Bombyx mori ERR (BmERR) and confirmed the promoter activity of this region. Interestingly, we found that 10 and 50 nM 20-hydroxyecdysone (20E) up-regulated the transcriptional activity of BmERR promoter. In addition, eight putative ecdysone response elements (EcREs) were predicted in the upstream sequence of BmERR. Based on their positions, the upstream sequence of BmERR was truncated into different fragments. Finally, an EcRE-like sequence (5′-AGTGCAGTAAACTGT-3′) was identified. Electrophoretic mobility shift assay (EMSA) and cell transfection experiments confirmed that this motif specifically binds to the complex formed between ecdysone receptor (BmEcR) and the ultraspiracle (BmUSP), a key complex in the 20E signaling pathway. Interference of BmERR or BmEcR mRNA in the embryonic cells of Bombyx mori significantly affected the expression of BmEcR and BmUSP. Overall, these results suggested that an EcRE element was identified from BmERR, and this will help understanding the detailed regulatory mechanism of ERR in insects.

Background: The myopia is a public health issue that attracts much attention. However, limited attention has been paid to the effect of primary school students' acceptance of health messages. Previous studies have found that framing effects and evidence types influence the persuasive effect of messages.Purpose: This study explored whether framing effects and evidence type influence the persuasive effect of myopia prevention messages among elementary school students and the influence of children's myopia prevention cognition was considered.Methods: A cross-sectional study was conducted among 1,493 elementary school students aged 9 to 13 in China from May to July 2020 by convenience sampling. Wilcoxon signed-rank test and multinomial logistic regression were used for data analysis.Results: Significant differences were found in the persuasive effect between statistical and non-statistical evidence messages (p < 0.001). Among non-statistical evidence messages, gain-framed messages showed a greater persuasive effect than loss-framed messages (p < 0.001). Among statistical evidence messages, loss-framed messages performed better than gain-framed messages (p < 0.001). Children's myopia prevention cognition exerted no significant effect on the persuasive effect of the messages (p > 0.05).Conclusion: This study demonstrated the influence of framing effect on the persuasive effect of myopia prevention messages among children aged 9 to 13 in China. Non-statistical evidence messages showed a better persuasive effect than statistical evidence messages. Different types of evidence influenced the persuasive effect of gain- and loss- framed messages. These findings have implications for strategies more or less likely to work in making myopia prevention messages for children.

Background: The population-based studies conducted thus far do not provide conclusive evidence of the link between diabetic retinopathy (DR) and stroke. The aim of the present systematic review was to determine whether DR is specifically associated with stroke.Methods: MEDLINE, Embase, and Web of Science were systematically searched from their inception to July 31, 2020. All cohort studies that reported associations between the presence of DR and incident stroke were included. The pooled hazard ratios (HRs), pooled risk ratios (RRs), and 95% confidence intervals (CIs) were calculated.Results: The meta-analysis included 19 cohort studies involving 81,452 diabetic patients. The pooled effect size of any DR related to stroke was 1.25 for HR (95% CI: 1.12–1.39; P < 0.0001) and 1.96 for RR (95% CI: 1.60–2.39; P < 0.0001). Subgroup analysis for the type of diabetes yielded pooled HR of 1.29 (95% CI: 1.10–1.50; P = 0.001) in patients with type 2 diabetes mellitus (T2DM). The pooled RR was 2.29 (95% CI: 1.77–2.96; P < 0.0001) in patients with T2DM. Two studies addressed the DR-related stroke among type 1 diabetes mellitus (T1DM) patients. One study found a significant association between DR and stroke (OR: 1.6; 95% CI: 1.1–2.3; P < 0.01), while the other did not identify an association between these two conditions (RR: 1.40; 95% CI: 0.62–2.18; P = 0.178).Conclusions: The presence of DR is associated with an increased risk of stroke in diabetic patients. This correlation is robust in T2DM patients but uncertain in T1DM patients. Our findings indicate that DR is an important biomarker for the prediction of stroke. To further validate the role of DR in stroke-risk stratification, additional research is required on the association between the stage of DR and stroke risk, and more studies including T1DM patients are necessary.

Increased groundwater extraction leads to the decrease of the extent of wetlands due to the implementation of a water-saving transformation project in an arid irrigation area. The application of integrated mitigation tools and strategies in China have increasing significance. In this study, an integrated approach (SWAT-MODFLOW) was followed; it is based on a soil and water assessment tool (SWAT) coupled with a modular three-dimensional finite difference groundwater model (MODFLOW). Recharge and evaporation values were estimated by SWAT and were then used to simulate groundwater in a MODFLOW model. Calibration (over the years 2000–2010) and validation (over the years 2010–2016) were performed, based on observed groundwater-level data; results showed that the combined SWAT-MODFLOW provides more accurate simulation and prediction of the dynamic changes of surface water and groundwater in irrigation areas than results from individual MODFLOW models. This method was applied to the Yanqi Basin, which is one of the most appropriate arid agricultural basins for modeling lake wetland and groundwater in China. The correlation coefficients (R2) between the simulated and real groundwater level are 0.96 and 0.91 in SWAT-MODFLOW and MODFLOW, respectively. With the gradual increase in the extraction to 248%, 0.62 × 108 m3 of groundwater discharged into the lake became −2.25 × 108 m3. The lake level drops 1.3 m compared with the current year, when the groundwater exploitation increases by 10 × 108 m3/year. Overall, the results of the coupling model offer scientific evidence for agricultural water management and lake recovery, so as to enhance the water use coordination.

The effectiveness of the bacteria antagonist Pseudomonas fluorescens to control green mold caused by Penicillium digitatum on oranges (Citrus sinensis Osbeck, cv. Jincheng) and the possible modes of action were evaluated. Whether in vitro or in vivo, treatments with cell-free autoclaved cultures or culture filtrate had limited capacity to suppress P. digitatum, while P. digitatum was significantly inhibited by bacterial fluid (P. fluorescens in the nutrient broth liquid medium) and bacterial suspension (P. fluorescens in sterile distilled water) with living cells. There was a positive relationship between the concentration of P. fluorescens in bacterial suspension and its biological efficacy. In addition, P. fluorescens was effective when applied preventatively but not when applied curatively. In the inoculated wounds, the population of P. fluorescens was an approximately 28- and 34-fold increase after being incubated at 20°C for 8 d and at 4°C for 16 d, respectively, and P. digitatum could effectively stimulate the growth and reproduction of P. fluorescens. Moreover, P. fluorescens was able to inhibit spore germination and germ tube elongation of P. digitatum as well as induce resistance on citrus peel by increasing the chitinase (CHI) activity and advancing the activities peaks of β-1,3-glucanase (GLU), peroxidase (POD), and phenylalanine ammonia lyase (PAL). All of these results support the potential application of P. fluorescens against green mold on postharvest citrus.