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Your search keyword '"Mengwen Yi"' showing total 6 results
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6 results on '"Mengwen Yi"'

1. A photo-activated aptamer-drug conjugate for targeted drug delivery

Author

Jing Liu, Xiangjun Liu, Mengwen Yi, Yue Sun, Tao Bing, Nan Zhang, and Dihua Shangguan

Subjects
Cytotoxins, Metals and Alloys, Oligonucleotides, General Chemistry, Aptamers, Nucleotide, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Naphthalimides, Drug Delivery Systems, Pharmaceutical Preparations, Doxorubicin, Cell Line, Tumor, Materials Chemistry, Ceramics and Composites
Abstract

A photo-activated aptamer-drug conjugate, HG1-9-DNP, was developed based on an aptamer HG1-9 and a photolabile naphthalimide derivative DNP. HG1-9-DNP could be internalized into cells mediated by TfR, then photocleaved, and released a promising cytotoxic agent, DNNH, which arrested the cell cycle at the G2/M phase, resulting in high photo-induced cytotoxicity.

Published
2022

3. A mitochondria-targeted near-infrared fluorescent probe for detection and imaging of HSO

Author

Mengwen, Yi, Xiangjun, Liu, Jing, Liu, Shengnan, Li, Dandan, Li, Xiangru, Zhang, Nan, Zhang, Yongbiao, Wei, and Dihua, Shangguan

Subjects
Optical Imaging, Humans, Sulfites, Sulfur Dioxide, Colorimetry, Fluorescent Dyes, HeLa Cells, Mitochondria
Abstract

Sulfur dioxide, an essential gas signaling molecule mainly produced in mitochondria, plays important roles in many physiological and pathological processes. Herein, a near-infrared fluorescent probe, A1, with good mitochondria targeting ability was developed for colorimetric and fluorescence detection of HSO

Published
2022

5. p-Aminostyryl thiazole orange derivatives for monitoring mitochondrial viscosity in live cells

Author

Yongbiao Wei, Lingling Zhang, Mengwen Yi, Tao Bing, Nan Zhang, Jing Liu, Dihua Shangguan, Xiangjun Liu, and Shilong Zhong

Subjects
biology, Viscosity, Lipid metabolism, Mitochondrion, biology.organism_classification, Fluorescence, Atomic and Molecular Physics, and Optics, Analytical Chemistry, Mitochondria, HeLa, chemistry.chemical_compound, Oleic acid, chemistry, Glycerol, Side chain, Biophysics, Quinolines, Humans, Benzothiazoles, Instrumentation, Spectroscopy, Fluorescent Dyes, HeLa Cells
Abstract

Viscosity of cell microenvironment plays a significant role in maintaining the normal life activities of cells. Particularly, the abnormal viscosity in mitochondria is closely associated with lots of diseases and cellular dysfunctions. Herein, we developed a group of p-aminostyryl thiazole orange derivatives with different amino side chains. These probes showed good fluorescence response to viscosity with twisted intramolecular charge transfer mechanism, among them, the probes with diethylamino (TOB), dibutylamino (TOC) and pyrrolidin (TOE) side chains showed better response to the viscosity with 78-fold, 55-fold, and 88-fold fluorescence enhancement in 95% glycerol solution respectively. TOB, TOC, and TOE could enter live cells and mainly located in mitochondria. Treatment HeLa cells with nystatin, lipopolysaccharide or oleic acid caused significant fluorescence enhancement of these probes, suggesting the good potential for monitoring the variation of mitochondrial viscosity, as well as for investigating the related physiological process of inflammation and lipid metabolism.

Published
2021

6. A 4-aminonaphthalimide-based fluorescent traceable prodrug with excellent photoinduced cytotoxicity

Author

Lingling Zhang, Dihua Shangguan, Xiangjun Liu, Jing Liu, Mengwen Yi, Shilong Zhong, Tao Bing, and Nan Zhang

Subjects
Light, Chemistry, Metals and Alloys, Antineoplastic Agents, Phthalimides, General Chemistry, Prodrug, Anticancer drug, Combinatorial chemistry, Fluorescence, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, Cell Line, Tumor, Materials Chemistry, Ceramics and Composites, Humans, Camptothecin, Prodrugs, Cytotoxicity, Derivative (chemistry), Blue light
Abstract

A blue light activated anti-cancer prodrug, NST, was designed based on a photoactive 4-aminonaphthalimide derivative and an anticancer drug, 10-hydroxycamptothecin. NST was hard to be taken up by living cells and showed negligible dark cytotoxicity. The irradiation caused photocleavage of NST and resulted in high cytotoxicity.

Published
2021

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