104 results on '"Mengue SS"'
Search Results
2. Initial impact and cost of a nationwide population screening campaign for diabetes in Brazil: a follow up study.
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Toscano CM, Duncan BB, Mengue SS, Polanczyk CA, Nucci LB, Costa e Forti A, Fonseca CD, Schmidt MI, and CNDDM Working Group
- Abstract
Background: In 2001 Brazilian citizens aged 40 or older were invited to participate in a nationwide population screening program for diabetes. Capillary glucose screening tests and procedures for diagnostic confirmation were offered through the national healthcare system, diagnostic priority being given according to the severity of screening results. The objective of this study is to evaluate the initial impact of the program. Methods: Positive testing was defined by a fasting capillary glucose ≥ 100 mg/dL or casual glucose ≥ 140 mg/dL. All test results were tabulated locally and aggregate data by gender and clinical categories were sent to the Ministry of Health. To analyze individual characteristics of screening tests performed, a stratified random sample of 90,106 tests was drawn. To describe the actions taken for positive screenees, a random sub-sample of 4,906 positive screenees was actively followed up through home interviews. Main outcome measures considered were the number of diabetes cases diagnosed and cost per case detected and incorporated into healthcare. Results: Of 22,069,905 screening tests performed, we estimate that 3,417,106 (95% CI 3.1 - 3.7 million) were positive and that 346,168 (290,454 - 401,852) new cases were diagnosed (10.1% of positives), 319,157 (92.2%) of these being incorporated into healthcare. The number of screening tests needed to detect one case of diabetes was 64. As many cases of untreated but previously known diabetes were also linked to healthcare providers during the Campaign, the estimated number needed screen to incorporate one case into the healthcare system was 58. Total screening and diagnostic costs were US$ 26.19 million, the cost per diabetes case diagnosed being US$ 76. Results were especially sensitive to proportion of individuals returning for diagnostic confirmation. Conclusion: This nationwide population-based screening program, conducted through primary healthcare services, demonstrates the feasibility, within the context of an organized national healthcare system, of screening campaigns for chronic diseases. Although overall costs were significant, cost per new case diagnosed was lower than previously reported. However, cost-effectiveness analysis based on more clinically significant outcomes needs to be conducted before this screening approach can be recommended in other settings. [ABSTRACT FROM AUTHOR]
- Published
- 2008
3. Hepatitis A vaccination coverage survey in 24-month-old children living in Brazilian capitals, 2020.
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Moura WÉA, Caetano KAA, Lima JORE, Campos LR, Silva GRDCE, Moraes JC, França AP, Domingues CMAS, Teixeira MDGLC, Teles SA, Silva AID, Ramos AN Jr, França AP, Oliveira ANM, Boing AF, Domingues CMAS, Oliveira CS, Maciel ELN, Guibu IA, Mirabal IRB, Barbosa JC, Lima JC, Moraes JC, Luhm KR, Caetano KAA, Lima LHO, Antunes MBC, Teixeira MDG, Teixeira MDC, Borges MFSO, Queiroz RCS, Gurgel RQ, Barata RB, Azevedo RNC, Oliveira SMDVL, Teles SA, Gama SGND, Mengue SS, Simões TC, Nascimento V, and Araújo WN
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- Humans, Brazil, Male, Female, Child, Preschool, Vaccination statistics & numerical data, Emigrants and Immigrants statistics & numerical data, Prevalence, Health Care Surveys, Poisson Distribution, Cross-Sectional Studies, Vaccination Coverage statistics & numerical data, Hepatitis A prevention & control, Hepatitis A Vaccines administration & dosage, Socioeconomic Factors
- Abstract
Objective: To estimate hepatitis A vaccination coverage in 24-month-old children and identify factors associated with non-vaccination., Methods: This was a survey involving a sample stratified by socioeconomic strata in capital cities (2020-2022), with coverage estimates and 95% confidence intervals (95%CI), the factor analysis was performed using the prevalence ratio (PR) by means of Poisson regression., Results: Among 31,001 children, hepatitis A coverage was 88.1% (95%CI 86.8;89.2). Regarding socioeconomic strata (A/B), the variable immigrant parents/guardians was associated with non-vaccination (PR = 1.91; 95%CI 1.09;3.37); in strata C/D, children of Asian race/skin color (PR = 4.69; 95%CI 2.30;9.57), fourth-born child or later (PR = 1.68; 95%CI 1.06;2 .66), not attending daycare/nursery (PR = 1.67; 95%CI 1.24;2.24) and mother with paid work (PR = 1.42; 95%CI 1.16;1.74) were associated with non-vaccination., Conclusion: Hepatitis A coverage was below the target (95%), suggesting that specificities of social strata should be taken into consideration., Main Results: Hepatitis A vaccination coverage was 88%. Non-vaccination was greater in children with immigrant guardians (strata A/B); of Asian race/skin color, fourth-born child or later, those not attending daycare/nursery and mother with paid work (C/D strata)., Implications for Services: The results of this study contributed to the Ministry of Health and Health Departments in monitoring vaccination coverage and identifying factors that may negatively impact hepatitis A vaccination coverage., Perspectives: Further research is needed on the impact of migration on hepatitis A vaccination and vaccination in general. Health managers should be attentive to the different factors affecting vaccination among social strata.
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- 2024
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4. Reliability of information recorded on the National Immunization Program Information System.
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Moraes JC, França AP, Guibu IA, Barata RB, Silva AID, Ramos AN Jr, França AP, Oliveira ANM, Boing AF, Domingues CMAS, Oliveira CS, Maciel ELN, Guibu IA, Mirabal IRB, Barbosa JC, Lima JC, Moraes JC, Luhm KR, Caetano KAA, Lima LHO, Antunes MBC, Teixeira MDG, Teixeira MDC, Borges MFSO, Queiroz RCS, Gurgel RQ, Barata RB, Azevedo RNC, Oliveira SMDVL, Teles SA, Gama SGND, Mengue SS, Simões TC, Nascimento V, and Araújo WN
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- Humans, Brazil, Reproducibility of Results, Infant, Child, Preschool, National Health Programs, Male, Female, Immunization Schedule, Vaccines administration & dosage, Immunization Programs statistics & numerical data, Vaccination Coverage statistics & numerical data, Information Systems statistics & numerical data, Information Systems standards, Vaccination statistics & numerical data
- Abstract
Objective: To analyze the reliability of records held on the National Immunization Program Information System (SI-PNI) in a subsample of children included in the national vaccination coverage survey in Brazilian state capitals and Federal District in 2020., Methods: This was a study of agreement between data recorded on vaccination cards (doses and dates) and on the SI-PNI for 4050 children with full coverage at 24 months., Results: Data on 3587 children were held on the SI-PNI, with losses of 11% (95%CI: 10;12). Total agreement between doses and dates in the two sources was 86% (95%CI: 86;87), however taking each dose and vaccine individually, variation was greater, with 32% of data in only one source., Conclusion: Part of the information was not recorded, but the discrepancy can be considered small. Nonetheless, underrecording of doses and children can compromise vaccination coverage estimates, altering the numerator and denominator data., Main Results: Subsample of 4,050 children, among those completing the full schedule at 24 months studied in the national survey, 11% had not been recorded on the SI-PNI, 32% had unrecorded doses (doses or dates) and there was 8% disagreement between vaccination cards and SI-PNI records., Implications for Services: Recognizing the difficulties faced by the SI-PNI and the discrepancies between sources is essential for adopting initiatives to improve data quality, so as to avoid inaccurate estimates of childhood vaccination coverage., Perspectives: This study is expected to contribute to improving the quality of records and the usability of data for monitoring vaccination coverage of the immunization program from the local to the national level.
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- 2024
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5. Vaccination coverage survey by social stratum in children up to 24 months of age in Londrina, Paraná, Brazil, between 2021 and 2022.
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Oliveira E, Moraes JC, França AP, Silva AID, Ramos AN Jr, França AP, Oliveira ANM, Boing AF, Domingues CMAS, Oliveira CS, Maciel ELN, Guibu IA, Mirabal IRB, Barbosa JC, Lima JC, Moraes JC, Luhm KR, Caetano KAA, Lima LHO, Antunes MBC, Teixeira MDG, Teixeira MDC, Borges MFSO, Queiroz RCS, Gurgel RQ, Barata RB, Azevedo RNC, Oliveira SMDVL, Teles SA, Gama SGND, Mengue SS, Simões TC, Nascimento V, and Araújo WN
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- Humans, Brazil, Infant, Female, Male, Child, Preschool, Mothers statistics & numerical data, Mothers psychology, Vaccine-Preventable Diseases prevention & control, Health Care Surveys, Sociodemographic Factors, Immunization Programs statistics & numerical data, Infant, Newborn, Vaccination Coverage statistics & numerical data, Vaccination statistics & numerical data, Socioeconomic Factors
- Abstract
Objective: To analyze vaccination coverage according to social strata in children up to 24 months old, living in the municipality of Londrina (PR), Brazil., Methods: This was a population-based survey conducted between 2021 and 2022, in which vaccination coverage and sociodemographic aspects of mothers and families were evaluated using Pearson's chi-square test., Results: In a sample of 456 children, complete vaccination coverage varied according to social strata, being 36.0% (95%CI 26.8;57.8); in stratum A; 59.5% (95%CI 26.1;86); in stratum B; 66.2% (95%CI 51.7;78.1); in stratum C; and 70.0% (95%CI 56.1;81.0) in stratum D., Conclusion: The analysis of vaccination coverage indicated that social stratum A is at highest risk for vaccine-preventable diseases., Main Results: The results of the study showed low full vaccination coverage in children up to 24 months of age in Londrina, being higher in the less financially advantaged social stratum, compared to the most advantaged., Implications for Services: The results found can support the qualification of the immunization program and enable, based on planning and ongoing health education, the definition of unique strategies to improve vaccination coverage., Perspectives: Future perspectives point to the importance of carrying out investigations into the challenges inherent to vaccination, as well as qualitative and quantitative research addressing health professionals to better understand the data.
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- 2024
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6. Vaccination coverage and delay in vaccination of infants born in 2017 and 2018 in municipalities in the Southern region of Brazil: National Vaccination Coverage Survey 2020.
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Luhm KR, Boing AF, Mengue SS, Daniel NS, Mélo TR, Farion RJ, França AP, Moraes JC, Silva AID, Ramos AN Jr, França AP, Oliveira ANM, Boing AF, Domingues CMAS, Oliveira CS, Maciel ELN, Guibu IA, Mirabal IRB, Barbosa JC, Lima JC, Moraes JC, Luhm KR, Caetano KAA, Lima LHO, Antunes MBC, Teixeira MDG, Teixeira MDC, Borges MFSO, Queiroz RCS, Gurgel RQ, Barata RB, Azevedo RNC, Oliveira SMDVL, Teles SA, Gama SGND, Mengue SS, Simões TC, Nascimento V, and Araújo WN
- Subjects
- Humans, Brazil, Infant, Time Factors, Infant, Newborn, Female, Vaccines administration & dosage, Male, Health Care Surveys, Vaccination Coverage statistics & numerical data, Immunization Schedule, Vaccination statistics & numerical data, Immunization Programs statistics & numerical data
- Abstract
Objective: To evaluate vaccination coverage and delay in vaccine dose administration in infants in six municipalities in the Southern region of Brazil., Methodology: National Vaccination Coverage Survey 2020, with infants born alive in 2017 and 2018, carried out from September 2020 to March 2022. Coverage of doses administered, doses administered on time and delay in dose administration were evaluated., Results: For 4681 infants analyzed, coverage for vaccines recommended up to 24 months was 68.0% (95%CI 63.9;71.8%) for doses administered and 3.9% (95%CI 2.7%;5.7%) for doses administered on time. Delay time for the majority of late vaccinations was ≤ 3 months. For some boosters, 25% of vaccine administration was delayed by ≥ 6 months., Conclusion: In addition to tracking vaccine defaulters, strategies are needed to encourage compliance with the vaccination schedule at the recommended ages., Main Results: Vaccination coverage for the set of vaccines recommended up to 24 months was 68.0% and 3.9% for on-time doses. Delay time for some doses exceeded six months in up to 25% of infants with delayed vaccination., Implications for Services: Monitoring vaccine administration at the recommended ages is necessary, with the adoption of strategies that reinforce routine vaccination to prevent vaccination delays and abandonment., Perspectives: Primary care in surveillance and care for infants needs to reinforce actions to ensure timely vaccination. Studies to deepen knowledge of vaccination delay, determinants and strategies for their reduction are necessary.
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- 2024
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7. Prevalence, reasons and factors associated with intentional nonadherence to prescribed medications: a population-based study.
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Sempé TDS, Pons EDS, Pizzol TDSD, Knauth DR, and Mengue SS
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- Humans, Female, Male, Cross-Sectional Studies, Middle Aged, Adult, Young Adult, Adolescent, Aged, Brazil, Socioeconomic Factors, Prevalence, Prescription Drugs administration & dosage, Medication Adherence statistics & numerical data
- Abstract
Objective: To evaluate the frequency, reasons and factors associated with intentional nonadherence to drug therapy., Methods: A population-based cross-sectional study was conducted with data from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM). The questionnaire consisted of sociodemographic questions, presence of chronic diseases, medication use, self-rated health, and medication use behaviors. Data analysis included Poisson regression models adjusted for variance., Results: A total of 31,573 individuals were included, most of whom were women (53.8%), with low level of education (57.7%), and self-rated good health (56.5%). Of those interviewed, 8.8% reported increasing the medication dose and 21.2% reported reducing it. The most common reason for dose reduction was the adverse effects of the medication. There were no differences in the reasons for increasing doses. Increasing or reducing doses were most commonly reported by younger people, with lower per capita income and worse self-rated health., Conclusion: A considerable portion of the respondents did not intentionally adhere to drug therapy. Understanding nonadherence and identifying those who practice it is crucial for creating effective strategies that promote adherence to treatment and prioritize patients' needs and perspectives.
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- 2024
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8. Description of vaccination coverage and hesitancy obtained by epidemiological survey of children born in 2017-2018, in Belo Horizonte and Sete Lagoas, Minas Gerais, Brazil.
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Simões TC, Campos Neto OH, França AP, Moraes JC, Silva AID, Ramos AN Jr, França AP, Oliveira ANM, Boing AF, Domingues CMAS, Oliveira CS, Maciel ELN, Guibu IA, Mirabal IRB, Barbosa JC, Lima JC, Moraes JC, Luhm KR, Caetano KAA, Lima LHO, Antunes MBC, Teixeira MDG, Teixeira MDC, Borges MFSO, Queiroz RCS, Gurgel RQ, Barata RB, Azevedo RNC, Oliveira SMDVL, Teles SA, Gama SGND, Mengue SS, Simões TC, Nascimento V, and Araújo WN
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- Humans, Brazil, Infant, Male, Female, Immunization Schedule, Child, Preschool, Vaccines administration & dosage, Vaccination Coverage statistics & numerical data, Socioeconomic Factors, Vaccination Hesitancy statistics & numerical data, Vaccination Hesitancy psychology, Vaccination statistics & numerical data
- Abstract
Objective: To describe vaccination coverage and hesitation for the basic children's schedule in Belo Horizonte and Sete Lagoas, Minas Gerais state, Brazil., Methods: Population-based epidemiological surveys performed from 2020 to 2022, which estimated vaccine coverage by type of immunobiological product and full schedule (valid and ministered doses), according to socioeconomic strata; and reasons for vaccination hesitancy., Results: Overall coverage with valid doses and vaccination hesitancy for at least one vaccine were, respectively, 50.2% (95%CI 44.1;56.2) and 1.6% (95%CI 0.9;2.7), in Belo Horizonte (n = 1,866), and 64.9% (95%CI 56.9;72.1) and 1.0% (95%CI 0.3;2.8), in Sete Lagoas (n = 451), with differences between socioeconomic strata. Fear of severe reactions was the main reason for vaccination hesitancy., Conclusion: Coverage was identified as being below recommended levels for most vaccines. Disinformation should be combated in order to avoid vaccination hesitancy. There is a pressing need to recover coverages, considering public health service access and socioeconomic disparities., Main Results: Vaccination coverage of children up to 4 years old was 50.2% in Belo Horizonte, and 64.9% in Sete Lagoas. Fear of severe reactions and believing that vaccination against eradicated diseases is unnecessary were the main reasons for vaccination hesitancy., Implications for Services: Recovery of high vaccination coverage among children, considering public health service access conditions and socioeconomic inequities. Acting on reasons for hesitancy that can assist in targeting actions., Perspectives: The multifactorial context of vaccination hesitancy demands the development of health education strategies to raise awareness about child immunization.
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- 2024
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9. Racial inequalities in child vaccination and barriers to vaccination in Brazil among live births in 2017 and 2018: an analysis of a retrospective cohort of the first two years of life.
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Boing AF, Boing AC, França AP, Moraes JC, Silva AID, Ramos AN Jr, França AP, Oliveira ANM, Boing AF, Domingues CMAS, Oliveira CS, Maciel ELN, Guibu IA, Mirabal IRB, Barbosa JC, Lima JC, Moraes JC, Luhm KR, Caetano KAA, Lima LHO, Antunes MBC, Teixeira MDG, Teixeira MDC, Borges MFSO, Queiroz RCS, Gurgel RQ, Barata RB, Azevedo RNC, Oliveira SMDVL, Teles SA, Gama SGND, Mengue SS, Simões TC, Nascimento V, and Araújo WN
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- Humans, Brazil, Infant, Female, Retrospective Studies, Child, Preschool, Male, Vaccination Coverage statistics & numerical data, Infant, Newborn, Adult, Cohort Studies, Socioeconomic Factors, Black People statistics & numerical data, Time Factors, Immunization Programs statistics & numerical data, Health Services Accessibility statistics & numerical data, Young Adult, White People statistics & numerical data, Vaccination statistics & numerical data, Healthcare Disparities statistics & numerical data, Mothers statistics & numerical data
- Abstract
Objective: To describe timely vaccination completion and obstacles in the first 24 months of life in Brazil, examining associations with maternal race/skin color., Methods: Study participants were 37,801 children born in 2017 and 2018 included in the National Immunization Coverage Survey. We calculated prevalence and 95% confidence intervals for timely vaccine completeness and obstacles at 5, 12 and 24 months of life, according to maternal race/skin color. Associations were analyzed using logistic regression., Results: 7.2% (95%CI 6.3;8.2) of mothers faced difficulties in taking their children to be vaccinated, and 23.4% (95%CI 21.7;25.1) were not vaccinated when taken. These proportions were 75% (95%CI 1.25;2.45) and 97% (95%CI 1.57;2.48) higher, respectively, among Black mothers. At least one vaccination was delayed among 49.9% (95%CI 47.8;51.9) and 61.1% (95%CI 59.2;63.0) of children by 5 and 12 months, respectively. These rates were higher among Black/mixed race mothers., Conclusion: There are racial inequalities in both the obstacles faced and in vaccination rates in Brazil., Main Results: Marked racial inequalities were found in the obstacles to vaccination of children under 24 months in Brazil and to timely vaccination at 5 months and in the first year of life., Implications for Services: Racial inequalities in the occurrence of vaccination shortcomings in health services, in the objective restrictions faced by families in taking their children to vaccination centers and in incomplete vaccination in a timely manner need to be addressed by the Brazilian National Health System., Perspectives: Equal public policies to address barriers to vaccination and qualification of health services need to be implemented. Studies need to deepen understanding of the structural determinants that lead to racial disparities.
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- 2024
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10. Folic acid supplementation during pregnancy and postpartum depressive symptoms.
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Lutz BH, Santos IDSD, Domingues MR, Murray J, Silveira MFD, Miranda VIA, Silveira MPT, Mengue SS, Pizzol TDSD, and Bertoldi AD
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- Pregnancy, Female, Humans, Brazil epidemiology, Postpartum Period, Folic Acid, Prevalence, Dietary Supplements, Depression epidemiology, Depression diagnosis, Depression, Postpartum epidemiology
- Abstract
Objective: To verify whether folic acid supplementation during pregnancy is associated with the occurrence of maternal depressive symptoms at three months postpartum, in the 2015 Pelotas Birth Cohort., Methods: This study included 4,046 women, who were classified into three groups: did not use folic acid supplementation during pregnancy; used during only one trimester of pregnancy; and used for two or three trimesters. Depressive symptoms were assessed at three months postpartum using the Edinburgh Postnatal Depression Scale (EPDS), at cutoff points ≥ 10 (mild symptoms) and ≥ 13 (moderate to severe intensity)., Results: The overall prevalence of mild symptoms was of 20.2% (95%CI 19.0-21.5), and moderate and severe was 11% (95%CI 10.0-12.0). The prevalence of EPDS ≥ 10 was of 26.8% (95%CI 24.0-29.5) among women who did not use folic acid and 18.1% for both those who used it during one trimester of pregnancy (95%CI 16.1-20.1) and those who used it for two or three trimesters (95%CI 16.0-20.2). The prevalence of EPDS ≥ 13 was of 15.7% (95%CI 13.5-17.9) in those who did not use folic acid, 9.1% (95%CI 7.5-10.6) in those who used it for one trimester, and 9.4% (95%CI 7.8-11.0) in those who used it for two or three trimesters. In the adjusted analyses, there was no statistically significant association between the use of folic acid during pregnancy and the occurrence of depressive symptoms at three months postpartum., Conclusion: There was no association between folic acid supplementation during pregnancy and postpartum depression at three months.
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- 2023
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11. Iron salt supplementation during gestation and gestational diabetes mellitus.
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Miranda VIA, Pizzol TDSD, Silveira MPT, Mengue SS, Silveira MFD, Lutz BH, and Bertoldi AD
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- Female, Pregnancy, Humans, Brazil, Dietary Supplements, Iron, Diabetes, Gestational
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- 2023
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12. Use of vitamins and/or minerals among adults and the elderly in urban areas of Brazil: prevalence and associated factors.
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Pavlak CDR and Mengue SS
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- Adult, Aged, Female, Humans, Male, Middle Aged, Brazil epidemiology, Cross-Sectional Studies, Prevalence, Socioeconomic Factors, Young Adult, Minerals therapeutic use, Urban Population statistics & numerical data, Vitamins therapeutic use
- Abstract
The purpose of the present study was to estimate the prevalence of vitamin and/or mineral use among urban Brazilian populations aged 20 years and over and to identify associated factors. Data from the National Survey on Access, Use and Promotion of the Rational Use of Medicines in Brazil (PNAUM) were analyzed and a population-based cross-sectional study with probability sampling was performed in urban areas of Brazil's five geographic regions from September 2013 to February 2014. The estimated prevalence of vitamin and/or mineral use was 4.8% (95%CI: 4.3-5.3), higher in women 6.4% (95%CI: 5.7-7.1) and in the elderly population 11.6% (95%CI: 10.5-12.8). Vitamin and/or mineral use was associated with the following factors: women, 60 years of age or older, economic class A/B, chronic disease(s) and self-perceived health held as average and very poor/poor. Multivitamins and multiminerals were the most used ones with 24.5% (95%CI 20.1-29.4), followed by calcium and vitamin D with 23.4% (95%CI 19.7-27.5). Data suggest that elderly women should be the reference public for actions aimed at promoting rational use. Nationwide epidemiological surveys should increase monitoring of these products to support the analysis of trends.
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- 2023
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13. Self-medication in children aged 0-12 years in Brazil: a population-based study.
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Pons EDS, Pizzol TDSD, Knauth DR, and Mengue SS
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- Humans, Child, Brazil epidemiology, Health Surveys, Cross-Sectional Studies, Socioeconomic Factors, Acute Disease, Pain, Fever
- Abstract
Objetive: Studies have shown that the practice of self-medicating children occurs worldwide and is independent of the country's economic level, medication policies, or access to health services. This study aimed to estimate and characterize the prevalence of self-medication in the Brazilian population of children aged up to 12 years., Methods: We analyzed the data of 7528 children aged up to 12 years whose primary caregivers responded to the National Survey on Access, Use and Promotion of Rational Use of Medicines in Brazil (PNAUM), a cross-sectional population-based study conducted in 245 Brazilian municipalities. The prevalence of self-medication was defined as the use of at least one medication without a doctor's or dentist's indication 15 days before the interview., Results: The prevalence of self-medication was 22.2% and was more frequent in older children belonging to poorer families and without health insurance. The acute conditions for which there was a higher frequency of self-medication were pain, fever, and cold/allergic rhinitis. Analgesics/antipyretics stood out among the most used medications for self-medication., Conclusions: The prevalence of self-medication to treat acute conditions was high in Brazilian children sampled in PNAUM, emphasizing the management of common symptoms such as pain, fever, and cold/allergic rhinitis in this age group. These findings reinforce the need for educational actions aimed at parents and caregivers.
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- 2023
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14. National Vaccine Coverage Survey 2020: methods and operational aspects.
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Barata RB, França AP, Guibu IA, Vasconcellos MTL, Moraes JC, Teixeira MGLC, Domingues CMA, Borges MFSO, Azevedo RNC, Oliveira CS, Oliveira ANM, Canales IT, Nascimento V, Queiroz RCS, Lima LHO, Ramos Jr AN, Barbosa JC, Mirabal IRB, Meira M, Antunes MBC, Teixeira MDC, Gurgel RQ, Carvalho MSI, Cesar T, Maciel ELN, Gama SGN, Luhm KR, Boing AF, Mengue SS, Oliveira SMVL, Lima JC, Teles SA, Caetano KAA, and Araújo WN
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- Child, Humans, Infant, Brazil, Pandemics, Vaccination, COVID-19, Vaccines, Vaccination Coverage
- Abstract
Objective: The national vaccination coverage survey on full vaccination at 12 and 24 months of age was carried out to investigate drops in coverage as of 2016., Methods: A sample of 37,836 live births from the 2017 or 2018 cohorts living in capital cities, the Federal District, and 12 inner cities with 100 thousand inhabitants were followed for the first 24 months through vaccine record cards. Census tracts stratified according to socioeconomic levels had the same number of children included in each stratum. Coverage for each vaccine, full vaccination at 12 and 24 months and number of doses administered, valid and timely, were calculated. Family, maternal and child factors associated with coverage were surveyed. The reasons for not vaccinating analyzed were: medical contraindications, access difficulties, problems with the program, and vaccine hesitancy., Results: Preliminary results showed that less than 1% of children were not vaccinated, full coverage was less than 75% at all capitals and the Federal District, vaccines requiring more than one dose progressively lost coverage, and there were inequalities among socioeconomic strata, favorable to the highest level in some cities and to the lowest in others., Conclusion: There was an actual reduction in full vaccination in all capitals and the Federal District for children born in 2017 and 2018, showing a deteriorating implementation of the National Immunization Program from 2017 to 2019. The survey did not measure the impacts of the COVID-19 pandemic, which may have further reduced vaccination coverage.
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- 2023
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15. Sources of medicines for hypertension and diabetes in Brazil: results from the National Health Survey.
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Mengue SS, Tierling VL, Tavares NUL, and Fontanella AT
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- Male, Humans, Adolescent, Adult, Brazil epidemiology, Antihypertensive Agents therapeutic use, Health Surveys, Hypertension drug therapy, Hypertension epidemiology, Diabetes Mellitus drug therapy, Diabetes Mellitus epidemiology
- Abstract
This study aims to analyze the sources people over 18 years of age use to obtain medication for the treatment of hypertension and diabetes, according to sociodemographic characteristics from 2013 to 2019. Data from the Brazilian National Health Survey were analyzed. Most individuals with diagnosis and prescription to pharmacological treatment reported obtaining medicines exclusively from one type of source. The percentage of people who acquired hypertension medicine exclusively from public pharmacies decreased, from 24.5% in 2013 to 16.2% in 2019; while there was an increase in those obtaining from the Popular Pharmacy program, from 23.5% to 31.4%; as well as for out-of-pocket payment, which rose from 30.9% to 35.5% The percentage of people who acquired diabetes medication exclusively from public pharmacies increased from 7.4% to 18.6% and with out-of-pocket payment increased from 21.6% to 26.8%, while the percentage of those who acquired from the Popular Pharmacy program decreased from 47.2% to 36.4%. The percentage of those who acquired medication from various sources decreased for both hypertension and diabetes. For men, white, and those with higher education, the source of medication acquisition, for both conditions, was mostly by out-of-pocket payment. The high number of medicine acquisition from public sources represents an advance in Brazil's response to the treatment of these conditions, but reducing regional differences still represents a challenge to be overcome by the healthcare system.
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- 2022
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16. Association between perceived stress and health-risk behaviours in workers.
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Cortes ML, Louzado JA, Oliveira MG, Bezerra VM, Mistro S, Medeiros DS, Soares DA, Silva KO, Kochergin CN, Carvalho VCHS, Amorim WW, and Mengue SS
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- Cross-Sectional Studies, Female, Humans, Male, Risk-Taking, Stress, Psychological epidemiology, Alcohol Drinking, Smoking epidemiology
- Abstract
Individuals who experience stress can engage in health-risk behaviours that may decrease work performance. The aim of this study was to determine perceived stress levels in Brazilian workers and verify whether perceived stress was associated with health-risk behaviours. Stress levels of 1,270 workers (1,019 men, 251 women) were assessed using the Perceived Stress Scale. The health-risk behaviours investigated were low intake of vegetables and fruits, daily smoking, high-risk alcohol consumption, physical inactivity, and the presence of obesity. The Student's t -test or one-way analysis of variance was used to assess differences in stress levels. Ordinal regression was used to determine the association between the degrees of stress and health-risk behaviours. Women had higher perceived stress levels than men. In addition, perceived stress levels were higher in those who had low socioeconomic status, were unmarried, had a negative perception of their health, were smokers, or had obesity. Smoking and the presence of two or more health-risk behaviours were associated with 1.84 (95% CI: 1.24-2.73) times and 1.49 (95% CI: 1.18-1.89) times higher odds of experiencing higher degrees of stress, respectively. In women, such an association was observed with the presence of obesity (odds ratio: 2.0; 95% CI: 1.01-3.98).
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- 2022
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17. Benzodiazepines utilization in Brazilian older adults: a population-based study.
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Freire MBO, Da Silva BGC, Bertoldi AD, Fontanella AT, Mengue SS, Ramos LR, Tavares NUL, Pizzol TDSD, Arrais PSD, Farias MR, Luiza VL, Oliveira MA, and Menezes AMB
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- Aged, Brazil epidemiology, Cross-Sectional Studies, Female, Humans, Male, Prevalence, Socioeconomic Factors, Benzodiazepines therapeutic use
- Abstract
Objective: To evaluate the utilization of benzodiazepines (BZD) in Brazilian older adults, based on the Pesquisa Nacional de Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - National Survey of Access, Use and Promotion of Rational Use of Medicines)., Methods: The PNAUM is a cross-sectional study conducted between 2013 and 2014, representing the Brazilian urban population. In the present study, we included 60 years or older (n = 9,019) individuals. We calculated the prevalence of BZD utilization in the 15 days prior to survey data collection according to independent variables, using a hierarchical Poisson regression model. A semistructured interview performed empirical data collection (household interview)., Results: The prevalence of BZD utilization in the older adults was 9.3% (95%CI: 8.3-10.4). After adjustments, BZD utilization was associated with female sex (PR = 1.88; 95%CI: 1.52-2.32), depression (PR = 5.31; 95%CI: 4.41-6, 38), multimorbidity (PR = 1.44; 95%CI: 1.20-1.73), emergency room visit or hospitalization in the last 12 months (PR = 1.42; 95%CI: 1.18-1.70 ), polypharmacy (PR = 1.26; 95%CI: 1.01-1.57) and poor or very poor self-rated health (PR = 4.16; 95%CI: 2.10-8.22). Utilization was lower in the North region (PR = 0.18; 95%CI: 0.13-0.27) and in individuals who reported abusive alcohol consumption in the last month (PR = 0.42; 95%CI: 0.19-0.94)., Conclusion: Despite contraindications, results showed a high prevalence of BZD utilization in older adults, particularly in those with depression, and wide regional and sex differences.
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- 2022
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18. Racial Differences in Blood Pressure Control from Users of Antihypertensive Monotherapy: Results from the ELSA-Brasil Study.
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Sousa CT, Ribeiro A, Barreto SM, Giatti L, Brant L, Lotufo P, Chor D, Lopes AA, Mengue SS, Baldoni AO, and Figueiredo RC
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- Adult, Angiotensin Receptor Antagonists therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Blood Pressure, Brazil, Calcium Channel Blockers therapeutic use, Cross-Sectional Studies, Humans, Longitudinal Studies, Race Factors, United States, Antihypertensive Agents pharmacology, Antihypertensive Agents therapeutic use, Hypertension drug therapy, Hypertension epidemiology
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Background: It seems that the worst response to some classes of antihypertensive drugs, especially angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, on the part of the Black population, would at least partially explain the worse control of hypertension among these individuals. However, most of the evidence comes from American studies., Objectives: This study aims to investigate the association between self-reported race/skin color and BP control in participants of the Longitudinal Study of Adult Health (ELSA-Brasil), using different classes of antihypertensive drugs in monotherapy., Methods: The study involved a cross-sectional analysis, carried out with participants from the baseline of ELSA-Brasil. Blood pressure control was the response variable, participants with BP values ≥140/90 mmHg were considered out of control in relation to blood pressure levels. Race/skin color was self-reported (White, Brown, Black). All participants were asked about the continuous use of medication. Association between BP control and race/skin color was estimated through logistic regression. The level of significance adopted in this study was of 5%., Results: Of the total of 1,795 users of antihypertensive drugs in monotherapy at baseline, 55.5% declared themselves White, 27.9% Brown, and 16.7% Black. Even after adjusting for confounding variables, Blacks using angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blocker (ARB), thiazide diuretics (thiazide DIU), and beta-blockers (BB) in monotherapy had worse blood pressure control compared to Whites., Conclusions: Our results suggest that in this sample of Brazilian adults using antihypertensive drugs in monotherapy, the differences in blood pressure control between different racial groups are not explained by the possible lower effectiveness of ACEIs and ARBs in Black individuals.
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- 2022
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19. Social Distancing, Mask Use, and Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, Brazil, April-June 2020.
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Gonçalves MR, Dos Reis RCP, Tólio RP, Pellanda LC, Schmidt MI, Katz N, Mengue SS, Hallal PC, Horta BL, Silveira MF, Umpierre RN, Bastos-Molina CG, Souza da Silva R, and Duncan BB
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- Brazil epidemiology, Case-Control Studies, Humans, Masks, Physical Distancing, COVID-19, SARS-CoV-2
- Abstract
We assessed the associations of social distancing and mask use with symptomatic, laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection in Porto Alegre, Brazil. We conducted a population-based case-control study during April-June 2020. Municipal authorities furnished case-patients, and controls were taken from representative household surveys. In adjusted logistic regression analyses of 271 case-patients and 1,396 controls, those reporting moderate to greatest adherence to social distancing had 59% (odds ratio [OR] 0.41, 95% CI 0.24-0.70) to 75% (OR 0.25, 95% CI 0.15-0.42) lower odds of infection. Lesser out-of-household exposure (vs. going out every day all day) reduced odds from 52% (OR 0.48, 95% CI 0.29-0.77) to 75% (OR 0.25, 95% CI 0.18-0.36). Mask use reduced odds of infection by 87% (OR 0.13, 95% CI 0.04-0.36). In conclusion, social distancing and mask use while outside the house provided major protection against symptomatic infection.
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- 2021
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20. Does socioeconomic inequality occur in the multimorbidity among Brazilian adults?
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Costa ÂK, Bertoldi AD, Fontanella AT, Ramos LR, Arrais PSD, Luiza VL, Mengue SS, and Nunes BP
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- Adult, Age Distribution, Brazil epidemiology, Cholesterol blood, Cross-Sectional Studies, Female, Health Status Disparities, Health Surveys, Humans, Male, Sex Distribution, Educational Status, Hypercholesterolemia epidemiology, Hypertension epidemiology, Multimorbidity, Social Class
- Abstract
Objective: To assess the prevalence of multimorbidity among Brazilian adults and its association with socioeconomic indicators., Methods: Cross-sectional study that used data from the Pesquisa Nacional Sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil (PNAUM - Brazilian National Survey on Access, Use and Promotion of Rational Use of Medicines), carried out between 2013 and 2014. The definition of multimorbidity was the coexistence, in a single individual, of two or more chronic diseases, measured through a list of 14 morbidities (self-reported medical diagnosis throughout life). Economic status and educational level were the socioeconomic indicators used, being the inequalities assessed through the Slope Index of Inequality (SII) and the Concentration Index, stratified by gender., Results: The study comprehended 23,329 adults (52.8% of which were women), with an average age of 37.9 years. Hypertension and high cholesterol levels were the most prevalent conditions. The prevalence of multimorbidity was of 10.9% (95%CI 10.1-11.7) representing nearly 11 million individuals in Brazil, of which 14.5% (95%CI 13.5-15.4) were women and 6.8% (95%CI 5.9-7.8) were men. The occurrence of multimorbidity was similar according to the socioeconomic indicators. In the inequality analysis, we observed absolute and relative differences in men with a higher purchasing power (SII = 3.7; 95%CI 0.3-7.0) and higher educational level (CIX = 7.1; 95%CI 0.9-14.7), respectively., Conclusions: The frequency of comorbidities in Brazilian adults is high, especially in absolute terms. We only observed socioeconomic inequalities in multimorbidities among men.
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- 2020
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21. Reasons for encounter in primary health care in Brazil.
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Chueiri PS, Gonçalves MR, Hauser L, Wollmann L, Mengue SS, Roman R, Rodrigues Agostinho Rech M, Soares MAV, Pertile J, and Harzheim E
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- Adolescent, Adult, Brazil, Cross-Sectional Studies, Humans, Referral and Consultation, Physicians, Primary Care, Primary Health Care
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Background: Primary health care (PHC) delivery in Brazil has improved in the last decades. However, it remains unknown whether the Family Health Strategy teams are meeting the health needs of the population., Objectives: To describe the reasons for encounter (RFEs) in PHC in Brazil and to examine variations in RFEs according to sex, age and geographic region., Methods: This descriptive study is part of a national cross-sectional study conducted in 2016. The sample was stratified by the number of PHC physicians per geographic region. Physicians who had been working for at least 1 year in the same PHC unit were included. For every participating physician, 12 patients aged ≥18 years who had attended at least two encounters were included. Patients were asked about their RFEs, which were classified according to the International Classification of Primary Care., Results: In 6160 encounters, a total of 8046 RFEs were coded. Seven reasons accounted for 50% of all RFEs. There was a high frequency of codes related to test results, medication renewal and preventive medicine. RFEs did not vary significantly by sex or geographic region, but they did by age group (P < 0.001). The rates of prescriptions, requests for investigations and referrals to specialized care were 71.1%, 42.8%, and 21.3%, respectively., Conclusion: This novel study opened the 'black box' of RFEs in PHC in Brazil. These findings can contribute to redefining the scope of PHC services and reorienting work practices in order to improve the quality of PHC in Brazil., (© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2020
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22. User evaluation of public pharmacy services in Brazil.
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Costa KS, Zaccolo AV, Tavares NUL, Arrais PSD, Luiza VL, Oliveira MA, and Mengue SS
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- Adult, Brazil, Cross-Sectional Studies, Female, Humans, Male, Young Adult, Pharmaceutical Services, Pharmacies
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Objective of this article is to evaluate aspects related to the services provided in SUS pharmacies in Brazil, according to users' perception. Data from the National Survey of Access, Use and Promotion of Rational Use of Medicines carried out between 2013 and 2014 were used. Individuals who obtained drugs from public pharmacies were analyzed. To calculate prevalence estimates, the total number of users of drugs with 95%CI was used as denominator. From the age group of 20 to 24 years up to 60 to 64 years, there were significant differences between men and women in terms of use of public pharmacies. More than 30% of people from all socioeconomic classes who did not obtain drugs from SUS pharmacies never thought about this possibility. Not having to wait much time to obtain the medication and a positive evaluation of the opening hours had a strong association with the positive evaluation of users of SUS pharmacies. Opening hours and waiting time are potential barriers in SUS pharmacies. The evaluation of users of SUS was positive, but it pointed to regional differences, and the identification of the magnitude of such differences can contribute to the planning of more effective and equitable policies.
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- 2020
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23. Use of statins for the secondary prevention of stroke: are we respecting the scientific evidences?
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Rodrigues JPV, Pereira LB, Zanetti MOB, Fontanella AT, Lima NKDC, Mengue SS, and Pereira LRL
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- Adult, Aged, Brazil epidemiology, Cross-Sectional Studies, Drug Utilization trends, Evidence-Based Medicine trends, Female, Health Care Surveys, Humans, Male, Middle Aged, Prevalence, Protective Factors, Recurrence, Risk Assessment, Risk Factors, Stroke diagnosis, Stroke epidemiology, Time Factors, Treatment Outcome, Young Adult, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Practice Patterns, Physicians' trends, Secondary Prevention trends, Stroke prevention & control
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Background: Stroke accounts for approximately as 5.0% of disability-adjusted years of life and 10.0% of all deaths worldwide. Secondary stroke prevention in surviving individuals, which includes the use of statins, reduces atherothrombotic stroke recurrence, complications and mortality. The present study aimed to characterize the Brazilian population with stroke history and estimate the prevalence of statin use as secondary prevention., Methods: This is a population-based cross-sectional study conducted in Brazilian urban areas. A total of 41.433 individuals were interviewed, representing 171 million of Brazilians, based on post-stratification weights. We included only participants aged 20 years or older who answered "yes" to the following question: "Did any doctor ever tell you that you had a stroke?" The main outcome was the prevalence of statin use among individuals who answered affirmatively. To identify the factors associated with stroke occurrence, the participants were categorized according to clinical and sociodemographic characteristics., Results: Only 24.2% (95% CI 19.9 - 29.1) of those who reported history of stroke regardless of other conditions also reported statin use. However, the results indicated that 52.9% (95% CI 43.6 - 62.0) of individuals who reported a previous diagnosis of dyslipidemia stated the use of statins. Regarding patients who reported stroke and did not report dyslipidemia history, only 9.1% (95% CI 5.9 - 13.8) referred to use statins., Conclusion: This study showed a low prevalence of statin use by individuals with a history of stroke in Brazil. Actions involving the organization of services and training of professionals may positively impact the rates of stroke recurrence., Competing Interests: Declarations of Competing Interest None, (Copyright © 2020 Elsevier Inc. All rights reserved.)
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- 2020
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24. Nationwide use of psychotropic drugs for treatment of self-reported depression in the Brazilian urban adult population.
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Ramos LR, Mari JJ, Fontanella AT, Pizzol TDSD, Bertoldi AD, and Mengue SS
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- Adult, Age Distribution, Brazil epidemiology, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Polypharmacy, Sex Distribution, Socioeconomic Factors, Young Adult, Antidepressive Agents therapeutic use, Depressive Disorder drug therapy, Depressive Disorder epidemiology, Psychotropic Drugs therapeutic use, Self Report, Urban Population statistics & numerical data
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Objective: Antidepressant use is increasing worldwide, but national data on psychotropic drug use by depressed patients in Brazil is lacking., Methodology: Between 2013 and 2014, a representative sample of urban adult individuals were asked if they had a diagnosis of chronic disease, had a medical indication for drug treatment, and were taking chronic medications at the time for each reported diagnosis. We analyzed the frequencies of reported depression and the medications related to this disease., Results: Overall, 6.1% of respondents reported depression. The prevalence increased with age - 9.5% among the elders - was higher among women (8.9%) and in the south of the country (8.9%). As a single disease, the prevalence of depression was higher among young people (17.6%). Among those with multimorbidity, the prevalence of depression rose to 25.7%. Of those who reported depression, 81.3% had medical indication for treatment and 90.3% were under treatment - this proportion was lower among young people (84.5%) and those living in the poorest region (78.6%). Antidepressants accounted for 47.2% of psychotropic drugs taken by respondents with depression, with regional differences - only 30% used antidepressants in the North. Polypharmacy was reported by 22% of those with depression and other chronic diseases., Conclusion: Depression in Brazil, is common among young adults as a single chronic disease and highly prevalent among people with chronic multimorbidity, especially the young. The treatment gap was larger among young people and in the less developed regions of the country.
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- 2020
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25. Factors associated with glycemic control in a sample of individuals with Diabetes Mellitus taken from the Longitudinal Study of Adult Health, Brazil, 2008-2010.
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Moraes HAB, Mengue SS, Molina MDCB, and Cade NV
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- Adult, Brazil epidemiology, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Socioeconomic Factors, Diabetes Mellitus epidemiology, Diabetes Mellitus therapy, Glycemic Control statistics & numerical data
- Abstract
Objective: to investigate factors associated with glycemic control in individuals with diabetes mellitus (DM)., Methods: this was a cross-sectional study, with participants in the Longitudinal Study of Adult Health with self-reported DM; binomial logistic regression was used., Results: 1,242 individuals were included; 54.2% had glycated hemoglobin ≥6.5%, showing inadequate glycemic control; factors associated with inadequate glycemic control were male sex (OR=1.39 - 95%CI 1.05;1.85), black skin color (OR=1.74 - 95%CI 1.22;2.48) or brown skin color (OR=1,57 - 95%CI 1.14;2.16), average occupation level (OR=1.63 - 95%CI 1.02;2.58), not having health insurance (OR=1.47 - 95%CI 1.09;1.96), use of insulin (OR=7.34 - 95%CI 3.56;15.15), increased waist-to-hip ratio (OR=1.87 - 95%CI 1.19;2.93), smoking (OR=1.73 - 95%CI 1.09;2.74), and poor or very poor self-rated health (OR=2.37 - 95%CI 1.17;4.83)., Conclusion: the results reinforce the multicausal context in glycemic control, which was associated with sociodemographic factors, lifestyles and health conditions.
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- 2020
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26. Access and regulation of specialized care in Rio Grande do Sul: the RegulaSUS strategy of TelessaúdeRS-UFRGS.
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Katz N, Roman R, Rados DV, Oliveira EB, Schmitz CAA, Gonçalves MR, Mengue SS, and Umpierre RN
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- Appointments and Schedules, Brazil, Capacity Building, Data Analysis, Health Services Accessibility statistics & numerical data, Humans, Primary Health Care statistics & numerical data, Referral and Consultation organization & administration, Referral and Consultation statistics & numerical data, Telemedicine statistics & numerical data, Time Factors, Waiting Lists, Health Services Accessibility organization & administration, Primary Health Care organization & administration, Telemedicine organization & administration
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In Primary Health Care (PHC), access, and integrality are strongly influenced by the coordination of care, which in turn receives a positive impact from the articulation of telehealth actions for teleregulation of care. We created a teleregulation method (RegulaSUS Project) based on specific protocols firmly grounded in scientific evidence. From data of the regulatory system and TelessaúdeRS, we explored the effects of RegulaSUS on PHC and access to specialized care. This method set comprehensive protocols, with a significant mean reduction of 30% in the specialized visits queue over 360 days. It reduced waiting time for medical clinical visits (median of 66 days) but not for surgical appointments. Waiting times for queued cases varied inversely, increasing for clinical and declining for surgical specialties. The use of teleconsultations unrelated to regulation increased with the exposure of professionals to RegulaSUS. The intervention evidence potentiality in the integration of health systems, mainly among low- and middle-income countries, and makes telehealth act as a meta-service, building efficient, qualified, and equitable networks.
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- 2020
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27. Medication Use among Pregnant Women from the 2015 Pelotas (Brazil) Birth Cohort Study.
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Lutz BH, Miranda VIA, Silveira MPT, Dal Pizzol TDS, Mengue SS, da Silveira MF, Domingues MR, and Bertoldi AD
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- Acetaminophen administration & dosage, Adult, Brazil, Cohort Studies, Dietary Supplements, Female, Folic Acid administration & dosage, Humans, Interviews as Topic, Pharmacoepidemiology, Pregnancy, Prenatal Care, Prevalence, Qualitative Research, Surveys and Questionnaires, Vitamins administration & dosage, Young Adult, Self Medication statistics & numerical data
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Background: Medication use during pregnancy is a common practice that has been increasing in recent years. The aim of this study is to describe medication use among pregnant women from the 2015 Pelotas (Brazil) Birth Cohort Study. Methods: This paper relies on a population-based cohort study including 4270 women. Participants completed a questionnaire about the antenatal period, including information about medication use. We performed descriptive analyses of the sample and the medications used and adjusted analyses for the use of medications and self-medication. Results: The prevalence of medication use was 92.5% (95% CI 91.7-93.3), excluding iron salts, folic acid, vitamins, and other minerals. The prevalence of self-medication was 27.7% (95% CI 26.3-29.1). In the adjusted analysis, women who had three or more health problems during pregnancy demonstrated higher use of medicines. Self-medication was higher in lower income groups and among smokers and multiparous women (three pregnancies or more). Acetaminophen, scopolamine, and dimenhydrinate were the medications most commonly used. Conclusions: This study describes the pattern of drug use among pregnant women in a population-based cohort study, with a high prevalence of self-medication. Greater awareness of the risks of self-medication during pregnancy is required, focusing on groups more prone to this practice, as well as ensuring qualified multidisciplinary prenatal care.
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- 2020
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28. Use of Medications by Breastfeeding Women in the 2015 Pelotas (Brazil) Birth Cohort Study.
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Lutz BH, Bassani DG, Miranda VIA, Silveira MPT, Mengue SS, Dal Pizzol TDS, da Silveira MF, and Bertoldi AD
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- Adolescent, Adult, Brazil, Cohort Studies, Female, Humans, Middle Aged, Weaning, Young Adult, Breast Feeding, Drug Utilization statistics & numerical data
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Background: This study describes medication use by women up to 3 months postpartum and evaluates the association between medication use by women who were still breastfeeding at 3 months postpartum and weaning at 6 and 12 months. Methods: Population-based cohort, including women who breastfed ( n = 3988). Medications were classified according to Hale's lactation risk categories and Brazilian Ministry of Health criteria. Duration of breastfeeding was analysed using Cox regression models and Kaplan-Meier curves, including only women who were still breastfeeding at three months postpartum. Results: Medication use with some risk for lactation was frequent (79.6% regarding Hale's risk categories and 12.3% regarding Brazilian Ministry of Health criteria). We did not find statistically significant differences for weaning at 6 or 12 months between the group who did not use medication or used only compatible medications and the group who used medications with some risk for lactation, according to both criteria. Conclusions: Our study found no association between weaning rates across the different breastfeeding safety categories of medications in women who were still breastfeeding at three months postpartum. Therefore, women who took medications and stopped breastfeeding in the first three months postpartum because of adverse side-effects associated with medications could not be addressed in this analysis.
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- 2020
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29. Use of drugs for gastrointestinal disorders: evidence from National Survey on Access, Use and Promotion of Rational Use of Medicines.
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Pereira LB, Gonçalves AMRF, Fernandes CSE, Fontanella AT, Francisco PMSB, Mengue SS, Borges RB, Pizzol TDSD, and Costa KS
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- Adult, Aged, Brazil, Cities, Cross-Sectional Studies, Drugs, Essential supply & distribution, Female, Health Surveys, Humans, Middle Aged, Pharmaceutical Preparations supply & distribution, Prescription Drugs supply & distribution, Socioeconomic Factors, Young Adult, Drug Utilization statistics & numerical data, Drugs, Essential therapeutic use, Gastrointestinal Diseases drug therapy, Health Services Accessibility statistics & numerical data
- Abstract
Objective To estimate the prevalence of use of drugs to treat gastrointestinal disorders, according to demographic, socioeconomic, and health characteristics of the Brazilian population. Methods This is a population-based survey that interviewed individuals residing in cities of the five regions in Brazil. The study sample was composed of 32,348 individuals aged 20 or more years. The profile of use of drugs for gastrointestinal disorders was evaluated considering the variables sex, age, healthcare plan, region, and number of chronic diseases. We also analyzed the frequency of individuals who declared using other drugs, besides those already employed for treatment of gastrointestinal disorders. Additionally, the estimated frequencies of the drug classes used were determined. Results The prevalence of use of drugs for gastrointestinal disorders in Brazil was 6.9% (95% confidence interval - 6.4-7.6), higher in females, among persons aged over 60 years, in those who had a private healthcare insurance, and presented with two or more chronic diseases. It was noted that 42.9% of the aged who used drugs for gastrointestinal disorders were also on polypharmacy. As to the classes of drugs, 82% corresponded to drugs for the food tract and metabolism, particularly proton pumps inhibitors. Conclusion The use of drugs for treatment of gastrointestinal disorders was significant among women and elderly. In this age group, consumption may be linked to gastric protection due to polypharmacy. This study is an unprecedented opportunity to observe the self-reported consumption profile of these drugs in Brazil and, therefore, could subsidize strategies to promote their rational use.
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- 2020
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30. Polypharmacy, socioeconomic indicators and number of diseases: results from ELSA-Brasil.
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Silva IR, Gonçalves LG, Chor D, Fonseca MJMD, Mengue SS, Acurcio FA, Pereira ML, Barreto SM, and Figueiredo RC
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- Adult, Aged, Brazil epidemiology, Female, Humans, Longitudinal Studies, Male, Middle Aged, Socioeconomic Factors, Chronic Disease drug therapy, Chronic Disease epidemiology, Polypharmacy
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Objective: To estimate the prevalence of polypharmacy, describe the pharmacotherapeutic classes used, and investigate whether polypharmacy is associated with demographic and socioeconomic indicators, regardless of the number of diseases, among participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline (2008-2010)., Method: In this analysis, 14,523 adults and elderly (35-74 years) participated. Polypharmacy was characterized as regular use of five or more medicines. The demographic and socioeconomic indicators analyzed were: gender, age, education level, per capita family income, and access to private health insurance. The independent association between demographic and economic indicators and polypharmacy was estimated by binary logistic regression., Results: The prevalence of polypharmacy was 11.7%. The most used drugs were those with action on the cardiovascular system. After adjustments, including by number of diseases, the chances of being on polypharmacy treatment were significantly higher among women, older participants and those with greatest number of diseases. Individuals without health insurance had lower chance to be under polypharmacy, as well as those with lower income., Conclusion: The occurrence of polypharmacy among ELSA-Brasil baseline participants was mainly due to drugs for the treatment of chronic diseases. The relation between polypharmacy and the female gender, as well as its association with old age, are in consonance with the results obtained in other studies. Despite the absence of an association between polypharmacy and education level, the income and health insurance results reinforce the existence of social inequalities regarding drug use.
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- 2020
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31. [Use of artificial sweeteners in Brazil: a household survey approach].
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Arrais PSD, Vianna MPN, Zaccolo AV, Moreira LIM, Thé PMP, Quidute ARP, Fontanella AT, Pizzol TDSD, Tavares NUL, Oliveira MA, Luiza VL, Ramos LR, Farias MR, Bertoldi AD, and Mengue SS
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- Adult, Brazil epidemiology, Female, Health Surveys, Humans, Male, Middle Aged, Prevalence, Self Report, Sex Factors, Socioeconomic Factors, Young Adult, Chronic Disease classification, Chronic Disease epidemiology, Sweetening Agents
- Abstract
The objective was to estimate the prevalence of artificial sweetener use by the adult Brazilian population and users' characteristics. Analysis of data from the Brazilian National Survey on Access, Utilization, and Promotion of Rational Use of Medicines (PNAUM, 2014), a nationwide population-based survey. The target outcome was self-reported use of sweeteners by Brazilians 20 years and older. The independent variables were sex, age, major geographic region of Brazil, schooling in complete years, and economic status according to the Brazilian Economic Classification Criterion of the Brazilian Association of Research Companies (ABEP). The health condition indicators were: self-reported noncommunicable diseases (NCDs), number of NCDs, and body mass index (BMI). Prevalence of sweetener use in the Brazilian adult population was 13.4% (95%CI: 12.5-14.3), and it was higher in females and in persons 60 years or older, in the Northeast and Southeast, among individuals from economic classes A and B, and among obese individuals. Persons with chronic diseases (especially diabetes) showed the highest prevalence of use of sweeteners, and their use increased with the number of reported comorbidities. Prevalence of use of artificial sweeteners was 13.4% and was associated with sociodemographic and health characteristics.
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- 2019
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32. The use of folic acid, iron salts and other vitamins by pregnant women in the 2015 Pelotas birth cohort: is there socioeconomic inequality?
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Miranda VIA, da Silva Dal Pizzol T, Silveira MPT, Mengue SS, da Silveira MF, Lutz BH, and Bertoldi AD
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- Adolescent, Adult, Brazil, Cohort Studies, Female, Humans, Middle Aged, Pregnancy, Socioeconomic Factors, Young Adult, Folic Acid administration & dosage, Iron, Dietary administration & dosage, Pregnant Women, Vitamins administration & dosage
- Abstract
Background: Many low- and middle-income countries recommend micronutrient supplements for pregnant women to improve their nutritional status, prevent possible deficiencies and avoid fetal healgth consequences. This study evaluated the influence of socioeconomic status on the use of folic acid, iron salts and other vitamins and minerals among pregnant women in the 2015 Pelotas Birth Cohort., Methods: This population-based birth cohort study was carried out with 4270 women. Participants were interviewed during pregnancy and at the maternity hospital about the antenatal period; including the use of iron salts, vitamins and other minerals. Descriptive analyses were performed to characterize the sample. The analyses were adjusted according to socioeconomic variables (maternal education, ethnicity, household income)., Results: The overall prevalence of the use of folic acid, iron salts or other vitamins and minerals was 91.0% (95% CI: 90.1-91.8). Specifically, 70.9% (95% CI: 69.5-72.3) used folic acid, 72.9% (95% CI: 71.5-74.3) used iron compounds, and 31.8% (95% CI: 30.3-33.2) used other vitamins or minerals. In the adjusted analysis, the use of iron salts was associated with nonwhite mothers, with ≤4 years of education and whose family income was less than or equal to the monthly minimum wage. The use of folic acid and other vitamins and minerals was associated with white mothers who were more highly educated and had a higher family income., Conclusion: Although folic acid and other vitamins and minerals were more frequently used in white, richer and more educated mothers, which indicates inequality, iron supplements were more frequently used in the poorer, less educated nonwhite mothers, suggesting the opposite association for this supplement.
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- 2019
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33. Drug use in delivery hospitalization: Pelotas births cohort, 2015.
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Silveira MPT, Miranda VIA, Silveira MFD, Pizzol TDSD, Mengue SS, and Bertoldi AD
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- Adolescent, Adult, Anesthesia, Epidural, Anesthesia, General, Anesthesia, Spinal, Brazil, Cohort Studies, Cross-Sectional Studies, Drug Prescriptions classification, Female, Hospitalization, Humans, Middle Aged, Postpartum Period, Pregnancy, Risk Factors, Socioeconomic Factors, Young Adult, Cesarean Section statistics & numerical data, Delivery, Obstetric statistics & numerical data, Drug Prescriptions statistics & numerical data, Drug Utilization statistics & numerical data
- Abstract
Objective: Trace the pattern of drug use during delivery hospitalization., Method: Cross-sectional study carried out from June to October 2015, included in the 2015 Pelotas births cohort. All women living in the urban area of the city who were hospitalized for delivery were part of the sample. We collected information regarding drug prescription and drug use by mothers during the whole period of hospitalization. Sociodemographic data were obtained in interview after delivery, and other data were obtained from medical charts. The drugs were classified according to the Anatomical Therapeutic Chemical system., Results: All study participants (1,392 women) used at least one drug, with the mean amount being larger the higher the age of the mother, both prepartum/during delivery and postpartum. It was also higher in cases of spinal anesthesia or general anesthesia, cesarean deliveries, school hospitals, and longer hospitalizations. Analysis of the sample as a whole showed no significant difference in the number of drugs used according to hospitalization type, but when stratified by length of hospital stay the mean was higher in SUS hospitalizations than in private and health insurance hospitalizations. Drugs for the nervous system were the most used (30.5%), followed by drugs for the alimentary tract and metabolism (13.8%). The use of anti-infective agents and drugs that act on the cardiovascular and respiratory systems was higher in mothers who underwent cesarean delivery. This study showed high drug consumption in the delivery hospitalization period, and showed cesarean delivery and epidural anesthesia as the main factors related to high drug consumption in this period., Conclusions: We found high drug consumption in the delivery hospitalization period, and the main factors were cesarean delivery and epidural anesthesia. Drugs that act on the nervous system were the most used.
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- 2019
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34. Test of health Literacy for Portuguese-speaking Adults.
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Maragno CAD, Mengue SS, Moraes CG, Rebelo MVD, Guimarães AMM, and Pizzol TDSD
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- Adult, Brazil, Comprehension, Cross-Cultural Comparison, Educational Measurement standards, Educational Status, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Middle Aged, Surveys and Questionnaires, Young Adult, Health Literacy standards, Translating
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Introduction: Health literacy has been evaluated in several countries by tools developed for local language and culture. This study aimed to adapt and to validate the Health Literacy Test (TLS) for the Brazilian Portuguese language based on the Test of functional health literacy in adults (TOFHLA)., Method: The TLS, translated and adapted to the Brazilian scenario based on the Test of functional health literacy in adults, was administered to 302 users of a clinic of a University in Santa Catarina from September to October 2013. Cronbach's Alpha coefficient, Spearman's correlation and Analysis of Variance were used to assess the internal consistency, the correlation between the parts of the test and association between sociodemographic variables and the score of the Test, respectively., Results: The average score of the test was 72,2, and 54.6% of participants had adequate health literacy, 19.2% had marginal health literacy and 26.2% had inadequate health literacy. The average score of the test was inversely related to the age of the participants and directly related to the level of education. There was no significant difference in the other sociodemographic characteristics. The internal consistency (Cronbach's alpha) was 0.953. The coefficients for the numerical and reading passages were 0.808 and 0.951, respectively. All the sections correlated positively and significantly with the Test, and also with each other., Conclusion: The validation of this test provides a new instrument to determine the literacy level in Brazilian adults.
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- 2019
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35. Too much or too little opioid use? A comment on Bosetti et al.
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Turmina Fontanella A, Molina-Bastos CG, da Silva Dal Pizzol T, and Mengue SS
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- Europe, Humans, Pain, Analgesics, Opioid, Opioid-Related Disorders
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- 2019
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36. Medicine package inserts from the users' perspective: are they read and understood?
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Pizzol TDSD, Moraes CG, Arrais PSD, Bertoldi AD, Ramos LR, Farias MR, Oliveira MA, Tavares NUL, Luiza VL, and Mengue SS
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- Adolescent, Adult, Brazil, Cross-Sectional Studies, Educational Status, Female, Health Knowledge, Attitudes, Practice, Health Literacy, Humans, Male, Middle Aged, Young Adult, Comprehension, Drug Information Services standards, Product Labeling
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Introduction: The written information on medicines has been acknowledged as an important tool for health education., Objective: To analyze the use and understanding of medicine package inserts by users and assess sociodemographic and medical factors associated with their comprehension., Method: Data in this analysis are part of the PNAUM National Survey - a cross-sectional population-based study conducted in Brazil. Descriptive statistics and the Pearson χ2 tests were performed to compare proportions between sociodemographic and medical characteristics, as well as use and understanding of medicine package inserts., Results: A total of 28.427 individuals responded to questions related to medicine package inserts. From these, 59.6% (95%CI 57.7 - 61.5) said they usually read the inserts, and 98.4% (95%CI 98.0 - 98.8) considered them necessary. Among people who read the medicine package inserts, more than half indicated difficulties with legibility (57.4%; 95%CI 55,2 - 59,6) and readability (54.1%; 95%CI 52.1 - 56.1). People from a lower education level reported greater difficulty in understanding them., Conclusion: The larger portion of the population usually read medicine package inserts. Nevertheless, people have difficulty in reading and understanding them.
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- 2019
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37. [Indication, access, and use of medicines for chronic respiratory diseases in Brazil: results from the National Survey on Access, Utilization, and Promotion of Rational Use of Medicines in Brazil (PNAUM), 2014].
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Leal LF, Bertoldi AD, Menezes AMB, Borges RB, Mengue SS, Gazzana MB, and Pizzol TDSD
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- Adult, Brazil epidemiology, Chronic Disease epidemiology, Cross-Sectional Studies, Drug Therapy, Female, Health Surveys, Humans, Male, Middle Aged, Pharmaceutical Preparations classification, Respiratory Tract Diseases diagnosis, Respiratory Tract Diseases epidemiology, Self Report, Sex Factors, Socioeconomic Factors, Young Adult, Chronic Disease drug therapy, Health Services Accessibility statistics & numerical data, Pharmaceutical Preparations administration & dosage, Respiratory Tract Diseases drug therapy
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The study aimed to estimate the prevalence of self-reported chronic respiratory diseases and the indication, access to, and use of medicines, as well as their sources, in the Brazilian adult population. Data were analyzed on adults 20 years and older from the National Survey on Access, Utilization, and Promotion of Rational Use of Medicines in Brazil (PNAUM), conducted from September 2013 to February 2014. Prevalence of chronic respiratory diseases was 3% (95%CI: 2.7-3.3). Of these individuals, 58.1% (95%CI: 51.8-64.0) had an indication for pharmacological treatment. Of those with indication for treatment, 77.1% (95%CI: 71.0-82.8) were using at least one of the prescribed drugs. Total access to therapy was 91.4% (95%CI: 79.9-96.6), and more than half of individuals with chronic respiratory diseases purchased at least one of the drugs in retail pharmacies (57.3%). The most frequently reported drug class was the association of a corticosteroid plus a long-acting beta-2 agonist in inhalation form, the most common example of which was the association budesonide/formoterol (20.3%; 95%CI: 16.0-25.4). According to our study, prevalence of self-reported chronic respiratory diseases was lower than in previous studies published on the Brazilian population. Nearly half of the population reporting chronic respiratory diseases did not have an indication for pharmacological treatment. Among those with such indication, approximately one-fourth were not using medications during the study period, and for those who were on medication, although access was high, they had to pay for their medicines.
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- 2018
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38. [Primary health care performance in Brazil and association with the More Doctors physician recruitment programCalidad de la atención primaria de salud en Brasil y relación con el Programa Más Médicos].
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Rech MRA, Hauser L, Wollmann L, Roman R, Mengue SS, Kemper ES, Florencio ASR, Alfaro G, Tasca R, and Harzheim E
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Objective: To assess the performance of primary health care (PHC) in Brazil and its association with the More Doctors Program (Programa Mais Médicos, PMM)., Method: This nationwide cross-sectional study used the Primary Care Assessment Tool validated for Brazilian Portuguese (PCATool-Brasil) to determine the achievement of PHC according to user experience associated with three physician categories: Brazilian physicians participating in the PMM, Cuban physicians participating in the PMM, and Brazilian physicians not linked to the PMM. The following PHC scores were calculated: overall PCA score, accessibility (first contact), and longitudinality. The association between PHC scores, physician category, and other user and physician characteristics was investigated using multilevel analysis., Results: The overall PCA score for Brazil was 6.78, and the longitudinality score was 7.43. There was no difference in these scores among the three physician categories. The overall accessibility score was 4.24. A small but significant difference (P < 0.001) in accessibility score was detected among physician categories: 4.43 for Cuban physicians participating in the PMM (CI: 4.32-4.54), 4.08 for Brazilian physicians participating in the PMM(CI: 3.98-4.18), and 4.20 for Brazilian physicians not linked to the PMM (CI: 4.09-4.32). Age, socioeconomic level, presence of chronic diseases, and home visits by physicians positively influenced the overall PCA score on multilevel analysis., Conclusions: The type of physician did not influence the primary care orientation (overall score) of the healthcare system in Brazil. PMM was associated with higher accessibility sores in more socioeconomically vulnerable areas. Multilevel analysis showed that PCH may be strengthened by the reinforcement of essential physician roles (such as home visits) and by improving access for socioeconomically vulnerable, younger populations or those without chronic diseases., Competing Interests: Conflitos de interesse. Estudo proposto por pesquisadores do Programa de Pós-Graduação em Epidemiologia, da Faculdade de Medicina da Universidade Federal do Rio Grande do Sul (UFRGS), e financiado pela Organização Pan-Americana de Saúde/Organização Mundial da Saúde (OPAS/OMS). Os autores declaram ter avaliado os dados conforme evidências, não havendo conflito de interesses.
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- 2018
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39. Cross-cultural adaptation of the Patient-Doctor Relationship Questionnaire (PDRQ-9) in Brazil.
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Wollmann L, Hauser L, Mengue SS, Agostinho MR, Roman R, Feltz-Cornelis CMV, and Harzheim E
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- Adolescent, Adult, Brazil, Cross-Cultural Comparison, Cross-Sectional Studies, Cultural Characteristics, Factor Analysis, Statistical, Female, Humans, Interviews as Topic standards, Male, Middle Aged, Primary Health Care, Psychometrics, Reference Values, Reproducibility of Results, Translations, Young Adult, Physician-Patient Relations, Surveys and Questionnaires standards
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Objective: To describe the process of cross-cultural adaptation of the Patient-Doctor Relationship Questionnaire (PDRQ-9), as well as compare the agreement between two different types of application., Methods: This is a cross-sectional study with 133 adult users of a Primary Health Service in Porto Alegre, State of Rio Grande do Sul, Brazil. The PDRQ-9 was answered by the participants as a self-administered questionnaire and in an interview. The instrument was also validated by interview, using data from 628 participants of the Mais Médicos Program Evaluation Research, which is a cross-sectional study with a systematic sample of Primary Care Services in all regions of Brazil. We evaluated the semantic, conceptual, and item equivalence, as well as factor analysis and reliability., Results: All items presented factor loading > 0.5 in the different methods of application and populations in the factor analysis. We found Cronbach's alpha of 0.94 in the self-administered method. We found Cronbach's alpha of 0.95 and 0.94 in the two different samples in the interview application. The use of PDRQ-9 with an interview or self-administered was considered equivalent., Conclusions: The cross-cultural adaptation of the PDRQ-9 in Brazil replicated the factorial structure found in the original study, with high internal consistency. The instrument can be used as a new dimension in the evaluation of the quality of health care in clinical research, in the evaluation of services and public health, in health management, and in professional training. Further studies can evaluate other properties of the instrument, as well as its behavior in different populations and contexts.
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- 2018
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40. Prevalence and characteristics of adverse drug events in Brazil.
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Sousa LAO, Fonteles MMF, Monteiro MP, Mengue SS, Bertoldi AD, Pizzol TDSD, Tavares NUL, Oliveira MA, Luiza VL, Ramos LR, Farias MR, and Arrais PSD
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- Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Brazil epidemiology, Child, Child, Preschool, Cross-Sectional Studies, Drug-Related Side Effects and Adverse Reactions classification, Educational Status, Female, Health Surveys statistics & numerical data, Humans, Infant, Infant, Newborn, Male, Middle Aged, Prevalence, Sex Factors, Surveys and Questionnaires, Young Adult, Drug-Related Side Effects and Adverse Reactions epidemiology, Self Medication statistics & numerical data
- Abstract
The aim of this study was to describe the prevalence of adverse drug events (ADEs) and associated factors reported by users of medicines in Brazil. This was a cross-sectional population-based study conducted from September 2013 to February 2014 with data from the Brazilian National Survey on Access, Use, and Promotion of Rational Use of Medicines (PNAUM). The study included all individuals that reported the use of medicines and identified, among them, all those reporting at least one problem with the medicine's use. A descriptive analysis was performed to estimate ADE prevalence and 95% confidence intervals (95%CI) among the target variables. Crude and adjusted prevalence ratios were calculated using Poisson regression to investigate factors associated with ADEs. Overall ADE prevalence in Brazil was 6.6% (95%CI: 5.89-7.41), and after multivariate analysis, higher prevalence was associated with female gender, residence in the Central and Northeast regions, consumption of more medicines, "bad" self-rated health, and self-medication. The drugs most frequently reported with ADEs were fluoxetine, diclofenac, and amitriptyline. The most frequent ADEs were somnolence, epigastric pain, and nausea. Most reported ADEs were mild, avoidable, and associated with medicines used frequently by the population. The study provided knowledge on the size of the problem with use of medicines in Brazil.
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- 2018
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41. Overall and Leisure-Time Physical Activity Among Brazilian Adults: National Survey Based on the Global Physical Activity Questionnaire.
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da Silva ICM, Mielke GI, Bertoldi AD, Arrais PSD, Luiza VL, Mengue SS, and Hallal PC
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- Adolescent, Adult, Aged, Brazil, Female, Humans, Male, Middle Aged, Public Health, Surveys and Questionnaires, Young Adult, Exercise psychology, Leisure Activities psychology
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Background: To describe overall physical activity prevalence measured by the Global Physical Activity Questionnaire as well as inequalities in leisure-time physical activity among Brazilian adults (15 y and older)., Methods: Data from the Brazilian Survey on Medicine Access, Utilization, and Rational Use of Medicines were analyzed. The study was carried out between September 2013 and February 2014. Physical activity was measured through Global Physical Activity Questionnaire and classified according to the recommendations of the World Health Organization. Additional analysis determined the contribution of each physical activity domain to the total amount of physical activity. Inequalities in terms of sex, age, and socioeconomic position were explored., Results: About one-third of the participants (37.1%; 95% confidence interval, 35.5-38.8) were physically inactive. Work-based activities were responsible for 75.7% of the overall physical activity. The prevalence of participants achieving physical activity guidelines considering only leisure-time activities was 17.8% (95% confidence interval, 16.7-19.2). Females and older participants were less active than their counterparts for both overall and leisure-time physical activity; socioeconomic status was positively associated to leisure-time physical activity., Conclusions: Major overall physical activity is attributed to work-related physical activity. Leisure-time physical activity, a key domain for public health, presents important gender and socioeconomic inequalities.
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- 2018
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42. Predisposing factors to the practice of self-medication in Brazil: Results from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM).
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Pons EDS, Knauth DR, Vigo Á, and Mengue SS
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- Adult, Aged, Brazil, Female, Humans, Male, Urban Population, Young Adult, Self Medication
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Objective: To understand the predisposing factors that lead to the practice of self-medication and the factors associated with the use of medicines via self-medication in the adult population of Brazil., Methods: The analyzed data are part of the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM), a survey whose population consisted of individual residents permanently domiciled in urban areas in Brazil. In this work, the data references the 31 573 respondents aged 20 or higher (76.2% of the final PNAUM sample). Poisson regression models with robust variance were used for estimating the independent effect of each variable with medicine use via self-medication., Results: Of the interviewees, 73.6% stated they had used some medication without medical recommendation if they had previously used the same product; 73.8% stated they had used non-prescribed medicine when the medicine was already present at home; and 35.5% stated they had used some non-prescribed medication when they knew someone who had already taken the same medication. The prevalence of self-medication was 18.3%. The variables associated with the highest probability of using medicine via self-medication were: geographic region within Brazil, gender, age group, per capita income, self-assessment of health, self-reported use of previously used non-prescribed medication, and self-reported use of non-prescribed medication when that medication was already present at home., Conclusions: The use of medicines via self-medication in Brazil is relatively frequent and influenced by previous experience and familiarity with the medications, and is more common among women and individuals with low self-assessment of health.
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- 2017
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43. Pharmaceutical services in the primary health care of the Brazilian Unified Health System: advances and challenges.
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Costa KS, Tavares NUL, Nascimento JMD Júnior, Mengue SS, Álvares J, Guerra AA Junior, Acurcio FA, and Soeiro OM
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- Brazil, Drug and Narcotic Control, Humans, Medication Adherence, Pharmaceutical Services organization & administration, Pharmaceutical Preparations supply & distribution, Pharmaceutical Services trends, Primary Health Care
- Abstract
This study is a synthesis of the main results of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), Evaluation Component of the Basic Pharmaceutical Services. Based on the critical narrative of the elements of Brazil's pharmaceutical policies, we discuss aspects related to the structure of the pharmaceutical services, the medicines' sanitary state, human resources, access to medicines, rational use and management. Despite the advances that reflect the commitment of the group of actors involved, the results of the Survey indicate challenges, such as equitable access to medicines, the structuring of pharmaceutical services, the improvement of logistics and administration, and the implementation of actions directed to pharmaceutical care in the health units.
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- 2017
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44. Pharmaceutical services in primary health care: interfederative agreement in the development of pharmaceutical policies in the Brazilian Unified Health System (SUS).
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Costa KS, Tavares NUL, Nascimento JMD Júnior, Mengue SS, Álvares J, Guerra AA Junior, Acurcio FA, and Soeiro OM
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- 2017
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45. Access and adherence to medication among people with diabetes in Brazil: evidences from PNAUM.
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Meiners MMMA, Tavares NUL, Guimarães LSP, Bertoldi AD, Pizzol TDSD, Luiza VL, Mengue SS, and Merchan-Hamann E
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- Adult, Brazil, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Socioeconomic Factors, Young Adult, Diabetes Mellitus drug therapy, Health Services Accessibility statistics & numerical data, Medication Adherence statistics & numerical data
- Abstract
Objective: To describe people with diabetes in Brazil and to compare their sociodemographic characteristics, access and self-reported adherence to diabetes prescribed drugs., Methods: Data analysis from the National Survey on Access, Use and Promotion of the Rational Use of Medicines, a household survey, with sampling by clusters, according to sex and age domains and national and macro-regional representativeness. Adults (≥ 20 years old) who reported having diabetes constituted the sample. The weighted frequencies of the variables in the sample were analyzed and the Pearson χ2 test was applied to evaluate the statistical significance of the differences between the strata for the data of access, form of financing and adherence to the drugs, considering the level of significance of 5%., Results: We found a higher proportion of women, people over 60 years and economy class C. Most participants reported having two or more comorbidities, in addition to diabetes, and taking five or more drugs. Regarding access, 97.8% say they have access to prescription drugs for diabetes and 70.7% say they get them totally free of charge. There was low adherence to anti-diabetic treatment, with significant macro-regional differences (p = 0,001), and greater vulnerability in the South and Northeast regions., Conclusion: Better access to diabetes medicines in the country has been demonstrated. However, to improve the efficiency of health public spending, it is necessary to achieve higher rates of adherence to treatment.
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- 2017
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46. Expanding Primary Care Access: A Telehealth Success Story.
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Gonçalves MR, Umpierre RN, D'Avila OP, Katz N, Mengue SS, Siqueira ACS, Carrard VC, Schmitz CAA, Molina-Bastos CG, Rados DV, Agostinho MR, Oliveira EB, Roman R, Basso J, Pfeil JN, Mendonça MVA, Moro RG, Frank T, Stürmer PL, and Harzheim E
- Abstract
Competing Interests: Conflicts of interests: the authors report none.
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- 2017
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47. Agreement between different recall periods in drug utilization studies.
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Moraes CG, Mengue SS, and Pizzol TDSD
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- Adolescent, Adult, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Time Factors, Young Adult, Drug Utilization statistics & numerical data, Mental Recall, Self Report
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Objective:: To assess the agreement between three recall periods for self-reported drug use using a 24-hour recall period as reference., Methods:: Participants were allocated into three groups with different recall periods of 7, 14 and 30 days and were interviewed at two different times. A 24-hour recall questionnaire was answered during the first interview, and a questionnaire on drug use over the different recall periods tested was answered during the second interview. The agreement between the questionnaires was evaluated using percent agreement and kappa., Results:: For continuous drugs, percent agreement varied between 92 and 99% and kappa varied between 0.71 and 0.97 for three periods tested. For drugs of occasional use, percent agreement varied between 63 and 81% and kappa varied between 0.27 and 0.52. The prevalence of drugs, particularly those of occasional use, increases with time., Conclusions:: The high level of agreement between the three recall periods suggests that all of them are valid for the investigation of drugs of continuous use.
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- 2017
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48. Access to medicines for chronic diseases in Brazil: a multidimensional approach.
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Oliveira MA, Luiza VL, Tavares NU, Mengue SS, Arrais PS, Farias MR, Pizzol TD, Ramos LR, and Bertoldi AD
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- Adult, Age Distribution, Brazil, Cross-Sectional Studies, Delivery of Health Care, Drugs, Essential supply & distribution, Female, Humans, Male, Middle Aged, National Health Programs, Prescription Drugs supply & distribution, Sex Factors, Socioeconomic Factors, Young Adult, Chronic Disease drug therapy, Health Services Accessibility statistics & numerical data, Health Surveys, Pharmaceutical Preparations supply & distribution, Pharmacies statistics & numerical data
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Objective: To analyze the access to medicines to treat non-communicable diseases in Brazil according to socioeconomic, demographic, and health-related factors, from a multidimensional perspective., Methods: Analysis of data from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM), household survey, sampling plan by conglomerates with representativeness of the Brazilian population and large areas of the country, according to sex and age domains. Data collected in 2013-2014 with sample of adults (≥ 20 years) who reported having non-communicable diseases and medical indication for use of medicines (n = 12,725). We assessed the prevalence of access to medicines for self-reported non-communicable diseases, considering four dimensions: availability, geographic accessibility, acceptability, and affordability. We applied Pearson's Chi-square test to assess the statistical significance of the differences between strata, considering the level of significance of 5%. We found prevalence of 94.3%, 5.2%, and 0.5% for full, partial, and null access, respectively. Higher prevalence was observed among seniors in the South compared to the Northeast; for those who reported having one non-communicable disease compared to those who reported having two or more; for those who needed one medicine compared to those who needed three or more; and for those who self-assessed their health as good or very good. Geographic accessibility was similar in the Unified Health System and in the private pharmacies (72.0%). Total availability of medicines was 45.2% in the Unified Health System, 67.4% in the Popular Pharmacy Program, and 88.5% in private pharmacies. Acceptability was 92.5% in the Unified Health System, 97.8% in the Popular Pharmacy Program, and 98.7% in private pharmacies. As to affordability, 2.6% of the individuals failed to take the medicines they should in the 30-day period prior to the interview due to financial difficulty. Prevalence of full access to medicines for non-communicable diseases in Brazil is high and presents significant differences for age group, region of the country, number of non-communicable diseases, and for medicines prescribed and self-assessment of health. The major barriers to access to medicines were identified in the dimensions analyzed., Objetivo: Analisar o acesso a medicamentos para tratar doenças crônicas não transmissíveis no Brasil segundo fatores socioeconômicos, demográficos e de saúde, sob perspectiva multidimensional., Métodos: Análise de dados da Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM), inquérito domiciliar, plano amostral por conglomerados com representatividade da população brasileira e grandes regiões do País, segundo domínios de sexo e idade. Dados coletados em 2013-2014 com amostra constituída por adultos (≥ 20 anos) que referiram ter doenças crônicas não transmissíveis e indicação médica para usar medicamentos (n = 12.725). Avaliou-se a prevalência de acesso aos medicamentos para doenças crônicas não transmissíveis autorreferidas, considerando quatro dimensões: disponibilidade, acessibilidade geográfica, aceitabilidade e capacidade aquisitiva. Aplicou-se teste Qui-quadrado de Pearson para avaliar a significância estatística das diferenças entre os estratos, considerando o nível de significância de 5%., Resultados: Foram encontradas prevalências de 94,3%, 5,2% e 0,5% para acesso total, parcial e nulo, respectivamente. Maiores prevalências ocorreram entre os idosos, na região Sul comparada à região Nordeste; naqueles que referiram ter uma doença crônica não transmissível comparados aos que referiram ter duas ou mais; naqueles que precisavam de um medicamento comparados aos que precisavam de três ou mais; e naqueles que autoavaliaram sua saúde como boa ou muito boa. A acessibilidade geográfica foi semelhante no Sistema Único de Saúde e nas farmácias privadas (72,0%). A disponibilidade total de medicamentos foi de 45,2% no Sistema Único de Saúde, 67,4% no Programa Farmácia Popular e 88,5% nas farmácias privadas. A aceitabilidade foi de 92,5% no Sistema Único de Saúde, 97,8% no Programa Farmácia Popular e 98,7% nas farmácias privadas. Quanto à capacidade aquisitiva, 2,6% dos indivíduos não tomou os medicamentos que deveria nos 30 dias anteriores à entrevista devido à dificuldade financeira., Conclusões: A prevalência do acesso total aos medicamentos para doenças crônicas não transmissíveis no Brasil é alta e apresenta diferenças significativas por faixa etária, região do País, número de doenças crônicas não transmissíveis e de medicamentos prescritos e autoavaliação da saúde. Foram identificadas as principais barreiras ao acesso a medicamentos nas dimensões analisadas., Competing Interests: The authors declare no conflict of interest.
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- 2016
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49. National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM): household survey component methods.
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Mengue SS, Bertoldi AD, Boing AC, Tavares NU, Pizzol TD, Oliveira MA, Arrais PS, Ramos LR, Farias MR, Luiza VL, Bernal RT, and Barros AJ
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- Adult, Age Distribution, Brazil, Chronic Disease, Cross-Sectional Studies, Family Characteristics, Female, Health Surveys statistics & numerical data, Humans, Male, Middle Aged, Sex Distribution, Socioeconomic Factors, Surveys and Questionnaires, Health Services Accessibility statistics & numerical data, Health Surveys methods, Pharmaceutical Preparations supply & distribution
- Abstract
Objective: To describe methodological aspects of the household survey National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM) related to sampling design and implementation, the actual obtained sample, instruments and fieldwork., Methods: A cross-sectional, population-based study with probability sampling in three stages of the population living in households located in Brazilian urban areas. Fieldwork was carried out between September 2013 and February 2014. The data collection instrument included questions related to: information about households, residents and respondents; chronic diseases and medicines used; use of health services; acute diseases and events treated with drugs; use of contraceptives; use of pharmacy services; behaviors that may affect drug use; package inserts and packaging; lifestyle and health insurance., Results: In total, 41,433 interviews were carried out in 20,404 households and 576 urban clusters corresponding to 586 census tracts distributed in the five Brazilian regions, according to eight domains defined by age and gender., Conclusions: The results of the survey may be used as a baseline for future studies aiming to assess the impact of government action on drug access and use. For local studies using a compatible method, PNAUM may serve as a reference point to evaluate variations in space and population. With a comprehensive evaluation of drug-related aspects, PNAUM is a major source of data for a variety of analyses to be carried out both at academic and government level., Objetivo: Descrever aspectos metodológicos do inquérito domiciliar da Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM) quanto ao desenho e implementação da amostragem e da amostra efetivamente obtida, seus instrumentos e implementação do campo., Métodos: Estudo transversal de base populacional com amostra probabilística em três estágios da população residente nos domicílios localizados na zona urbana do Brasil. O trabalho de campo foi desenvolvido entre setembro de 2013 e fevereiro de 2014. O instrumento de coleta de dados incluiu questões relativas a: informações do domicílio, dos moradores e dos entrevistados; doenças crônicas e medicamentos utilizados; uso de serviços de saúde; doenças e eventos agudos tratados com medicamentos; uso de contraceptivos; uso de serviços de farmácia; comportamentos que podem afetar o uso de medicamentos; bulas e embalagens; estilo de vida e planos de saúde., Resultados: Foram realizadas 41.433 entrevistas em 20.404 domicílios e 576 conglomerados que correspondem a 586 setores censitários distribuídos nas cinco regiões do Brasil, segundo oito domínios definidos por grupos de idade e sexo., Conclusões: Os resultados obtidos no inquérito podem ser utilizados como uma linha de base para futuros estudos que pretendam avaliar o impacto de ações governamentais nas áreas de acesso e de utilização de medicamentos. Para estudos locais que venham a usar um método compatível, a PNAUM pode servir como ponto de referência para avaliação de variações do espaço e da população. Com ampla avaliação dos aspectos relacionados aos medicamentos, a PNAUM é uma grande fonte de dados para as mais variadas análises, que podem ser conduzidas tanto no meio acadêmico como no âmbito governamental., Competing Interests: The authors declare no conflict of interest.
- Published
- 2016
- Full Text
- View/download PDF
50. Free access to medicines for the treatment of chronic diseases in Brazil.
- Author
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Tavares NU, Luiza VL, Oliveira MA, Costa KS, Mengue SS, Arrais PS, Ramos LR, Farias MR, Pizzol TD, and Bertoldi AD
- Subjects
- Adult, Age Distribution, Brazil, Chi-Square Distribution, Cross-Sectional Studies, Female, Health Expenditures statistics & numerical data, Health Surveys, Humans, Male, Middle Aged, Sex Distribution, Socioeconomic Factors, Chronic Disease drug therapy, Drug Therapy, Drugs, Essential supply & distribution, Health Services Accessibility statistics & numerical data, Pharmaceutical Preparations supply & distribution, Pharmaceutical Services organization & administration
- Abstract
Objective: To analyze the free access to medicines for the treatment of chronic diseases in the Brazilian population, according to demographic and socioeconomic factors. We also analyzed the most used pharmacological groups, according to funding source: free-of-charge or out-of-pocket paid., Methods: Analysis of data from the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), a population-based household survey, of cross-sectional design, based on probabilistic sample of the Brazilian population. We analyzed as outcome the prevalence of free access (free-of-charge) to all medicines for treatment of the reported chronic diseases, in the last 30 days. We studied the following independent variables: sex, age group, education in complete years of school, economic class, health plan, and geographical region of residence. We estimated the prevalences and 95% confidence intervals (95%CI) and applied the Pearson's Chi-squared test to assess the differences between the groups, considering a 5% significance level., Results: About half of adults and older adults who have had full access to the treatment of chronic diseases in Brazil obtained all needed medicines for free (47.5%; 95%CI 45.1-50.0). The prevalences of free access were higher among men (51.4%; 95%CI 48.1-54.8), age group of 40-59 years (51.1%; 95%CI 48.1-54.2), and in the poorest social classes (53.9%; 95%CI 50.2-57.7). The majority of medicines that act on the cardiovascular system, such as diuretics (C03) (78.0%; 95%CI 75.2-80.5), beta-blockers (C07) (62.7%; 95%CI 59.4-65.8), and the agents that work in the renin-angiotensin system (C09) (73.4%; 95%CI 70.8-75.8), were obtained for free. Medicines that act on the respiratory system, such as agents against obstructive airway diseases (R03) (60.0%; 95%CI 52.7-66.9) were mostly paid with own resources., Conclusions: Free access to medicines for treatment of chronic diseases occurs to a considerable portion of the Brazilian population, especially for the poorest ones, indicating decreased socioeconomic inequalities, but with differences between regions and between some classes of medicines., Objetivo: Analisar o acesso gratuito ao tratamento medicamentoso para doenças crônicas na população brasileira, segundo fatores socioeconômicos e demográficos. Analisaram-se também os grupos farmacológicos mais utilizados, segundo fonte de financiamento: gratuito ou pago do próprio bolso., Métodos: Análise de dados oriundos da Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM), inquérito domiciliar de base populacional, de delineamento transversal, baseado em amostra probabilística da população brasileira. O desfecho analisado foi a prevalência de acesso gratuito (sem pagamento) a todos os medicamentos para tratamento das doenças crônicas referidas, nos últimos 30 dias. As variáveis independentes investigadas foram: sexo, faixa etária, escolaridade em anos completos de estudo, classe econômica, plano de saúde e região geográfica de residência. Foram estimadas as prevalências e calculados intervalos de 95% de confiança (IC95%) e aplicado o teste Qui-quadrado de Pearson para avaliação das diferenças entre os grupos, considerando nível de significância de 5%., Resultados: Cerca de metade dos adultos e idosos que tiveram acesso total ao tratamento de doenças crônicas no Brasil obtiveram todos os medicamentos que necessitavam gratuitamente (47,5%; IC95% 45,1-50,0). As prevalências de acesso gratuito foram maiores entre os homens (51,4%; IC95% 48,1-54,8), na faixa etária de 40-59 anos (51,1%; IC95% 48,1-54,2) e nas classes sociais mais pobres (53,9%; IC95% 50,2-57,7). Grande parte dos medicamentos que atuam no sistema cardiovascular, como os diuréticos (C03) (78,0%; IC95% 75,2-80,5), betabloqueadores (C07) (62,7%; IC95% 59,4-65,8) e os agentes que atuam no sistema renina-angiotensina (C09) (73,4%; IC95% 70,8-75,8) foram obtidos de forma gratuita. Os medicamentos que atuam no sistema respiratório como os agentes contra doenças obstrutivas das vias aéreas (R03) (60,0%; IC95% 52,7-66,9) foram na sua maioria pagos do próprio bolso., Conclusões: O acesso gratuito aos medicamentos para tratamento das doenças crônicas ocorre para uma considerável parcela da população brasileira, principalmente para os mais pobres, indicando diminuição das desigualdades socioeconômicas, mas com diferenças regionais e entre algumas classes de medicamentos., Competing Interests: The authors declare no conflict of interest.
- Published
- 2016
- Full Text
- View/download PDF
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