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9 results on '"Menghuai Ma"'

1. A case report of right‐sided heart failure secondary to JAK2‐mutation Loeffler endocarditis

Author

Xi Liu, Limin Liu, Zhiguo Yan, Lin Sun, Menghuai Ma, Yi Xiang, Xiang Cai, Xiaoqi Wang, and Wenhui Yang

Subjects
Eestrictive cardiomyopathy, Heart failure, Hypereosinophilic cardiomyopathy, Hypereosinophilic syndrome, Loeffler endocarditis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Loeffler's endocarditis (LE) is the cardiac manifestation of hypereosinophilic syndrome. We present a case of LE in a 45‐year‐old female, resulting in diffuse endothelial fibrosis and severe right‐sided heart failure. The patient was admitted with dyspnoea and oedema, with haematology revealing an absolute eosinophil count of 20.9 × 109. Imaging showed near‐complete obliteration of the right ventricular apical and formation of thromboses. Endomyocardial biopsy indicated diffuse fibrous hyperplasia of the endocardium with fibrinous thrombi rich in eosinophils. Molecular and cytogenetic analyses of bone marrow cells showed no signs of FIP1L1‐PDGFRA fusion, PDGFRB mutation, abnormal myeloid maturation, or a lymphoproliferative disorder. Flow cytometry indicated no clonality, ruling out chronic eosinophilic leukaemia. Gene mutation screening discovered a p.L583_A586delinesS mutation in the JAK2 gene. Following treatment with ruxolitinib, the patient's eosinophil levels normalized, but unfortunately, the damage to the heart was irreversible. The patient was hospitalized multiple times due to right heart failure and resistance to diuretics. After thorough discussions with the medical team, it was determined that a heart transplantation would be the most effective treatment. Following the surgery, the patient successfully navigated the postoperative critical period with the support of an intra‐aortic balloon pump (IABP), continuous renal replacement therapy (CRRT), and ventilator‐assisted ventilation but subsequently developed an acquired Intensive care unit‐acquired weakness (ICU‐AW) and a depressive state. Fortunately, the patient gradually recovered from these complications.

Published
2024
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3. The impact of growth differentiation factor 15 on the risk of cardiovascular diseases: two-sample Mendelian randomization study

Author

Zhuo Wang, Fangkun Yang, Menghuai Ma, Qinyi Bao, Jinlian Shen, Feiming Ye, and Xiaojie Xie

Subjects
Cardiovascular diseases, Growth differentiation factor 15, Mendelian randomization, Atrial fibrillation, Cardioembolic stroke, Coronary artery disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Growth differentiation factor 15 (GDF-15), a stress responsive cytokine, belongs to transforming growth factor β cytokine superfamily. Some evidence support that it’s involved in inflammation, coagulation, oxidative stress, endothelial dysfunction, and hemostasis. However, it’s still controversial whether GDF-15 directly contributes to the morbidity and mortality of patients suffered with cardiovascular disease (CVD). Besides prospective cohort study and randomized controlled trial, Mendelian randomization (MR) is a genetic epidemiological method that exploits genetic variants as unbiased proxies for modifiable to determine the causal relationships between exposures and health outcomes. Herein, we introduced a two-sample MR approach to evaluate the causal relationships of circulating GDF-15 levels with major CVDs incidence. Methods Genetic instruments and summary statistics for two-sample MR analysis were obtained from 5 independent large genome-wide association studies (GWAS) to investigate the causal correlation between circulating GDF-15 levels and 9 CVDs, respectively. Conventional inverse variance weighted method was adopted to evaluate the causality of GDF-15 with different outcomes; weighted median and MR egger were used for sensitivity analyses. Results Among 9 SNPs identified from 5 GWASs in 2.6 million individuals, 5 SNPs (rs1227731, rs3195944, rs17725099, rs888663, rs749451) coming from chromosome 19 and containing the PGPEP1 and GDF-15 genes were employed. Based on the instruments, circulating GDF-15 levels significantly linked to the increased risk of cardioembolic stroke, atrial fibrillation, coronary artery disease and myocardial infarction. However, no significant causal association was observed for circulating GDF-15 levels with the incidence of any ischemic stroke, large-artery atherosclerotic stroke, small vessel stroke, heart failure and nonischemic cardiomyopathy. Conclusions The MR study provides with genetic evidence for the causal relationship of circulating GDF-15 levels with the increased risk of cardioembolic stroke, atrial fibrillation, coronary artery disease and myocardial infarction, but not any ischemic stroke, large-artery atherosclerotic stroke, small vessel stroke, heart failure and nonischemic cardiomyopathy. It indicates that GDF-15 might be a promising biomarker or potential therapeutic target for some CVDs.

Published
2020
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4. Sex-Specific Genetically Predicted Iron Status in relation to 12 Vascular Diseases: A Mendelian Randomization Study in the UK Biobank

Author

Xiaojie Xie, Zhuo Wang, Feiming Ye, Fangkun Yang, Menghuai Ma, Qinyi Bao, and Jinlian Shen

Subjects
Male, Article Subject, Iron, Physiology, 030204 cardiovascular system & hematology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Varicose veins, Mendelian randomization, medicine, Humans, Vascular Diseases, 030212 general & internal medicine, Coronary atherosclerosis, Biological Specimen Banks, Sex Characteristics, General Immunology and Microbiology, biology, medicine.diagnostic_test, Transferrin saturation, business.industry, Incidence (epidemiology), General Medicine, Mendelian Randomization Analysis, Ferritin, biology.protein, Serum iron, Medicine, Female, medicine.symptom, business, Biomarkers, Research Article
Abstract

Background. Iron overload has been implicated in the pathogenesis of varicose veins (VVs). However, the association of serum iron status with other vascular diseases (VDs) is not well understood, which might be a potential target for VD prevention. This study was aimed at investigating the causal associations between iron status and VDs using the Mendelian randomization (MR) method. Methods. A two-sample MR was designed to investigate whether iron status was associated with VDs, based on iron data from a published genome-wide association study meta-analysis of 48,972 subjects of European descent and VD data obtained from the UK Biobank, including 361,194 British subjects (167,020 males and 194,174 females). We further explored whether there was sex difference in the associations between genetically predicted iron status and VDs. Results. The results demonstrated that iron status had a significant causal effect on VVs of lower extremities ( P < 0.001 ) and a potential effect on coronary atherosclerosis ( P < 0.05 for serum iron, ferritin, and transferrin saturation, respectively), but not on other VDs. Furthermore, higher iron status exerted a detrimental effect on VVs of lower extremities in both genders ( P < 0.05 ) and a protective effect on male patients with coronary atherosclerosis ( P < 0.05 for serum iron, ferritin, and transferrin saturation, respectively). Conclusions. This MR study provides robust evidence that higher iron status increases the risk of VVs of lower extremities, whereas it reduces the incidence of coronary atherosclerosis in the male population, which indicates that iron has divergent effects on vascular pathology.

Published
2020
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5. Long persistent Sinus arrest and Torsades de pointes association with Ibutilide after Atrial Fibrillation ablation：A Case Report

Author

Qing Li, Jinrui Guo, Ke Liu, Menghuai Ma, Tao Guo, Jun Liu, and Guodong Niu

Abstract

Ibutilide is commonly used for conversion of atrial fibrillation (AF) during catheter ablation procedure. Sinus arrest or Torsades de Pointes (TdP) is mainly complication of ibutilide, however, is recovery spontaneously after a few hours.We present a patient suffering long persistent sinus arrest and Torsades de pointes following administration of ibutilide for cardioversion of persistent AF after radiofrequency ablation.

Published
2022
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6. The impact of growth differentiation factor 15 on the risk of cardiovascular disease: evidence from Mendelian randomization study

Author

Feiming Ye, Fangkun Yang, Xiaojie Xie, Qinyi Bao, Zhuo Wang, Jinlian Shen, and Menghuai Ma

Subjects
embryonic structures, Mendelian randomization, Disease, GDF15, Biology, Bioinformatics
Abstract

Background: Growth differentiation factor 15(GDF-15) concentration is apparently associated with cardiovascular disease, but whether there is a causal relationship has not been testified. Methods: We utilized Mendelian randomization to assess the function of GDF-15 in incidence of cardiovascular disease. The single-nucleotide polymorphism- GDF-15 association evaluations came from meta-analysis of genome-wide association study (GWAS). Besides inverse-variance weighted, MR-Egger test and weighted median method were applied to examine sensitivity. Results: Based on the instruments, GDF-15 level linked to the increasing risk of cardioembolic stroke (1.06, OR 1.09 per SD increase, 95% CI 1.01, 1.19) , atrial fibrillation (OR 1.03 per SD increase, 95% CI 1.0, 1.06), coronary artery disease (OR 0.94 per SD increase, 95% CI 0.89, 0.99) and myocardial infarction (OR 0.94 per SD increase, 95% CI 0.90, 0.98). However, the significant causal relationship between GDF-15 and the other cardiovascular diseases was not found in our study. Conclusions: The result suggested that GDF-15 was causally associated with the risk of cardioembolic stroke,atrial fibrillation, coronary artery disease and myocardial infarction, providing us conceivable strategies to alleviate the burden of cardiovascular disease.

Published
2020
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8. Association of plasma polyunsaturated fatty acids with arterial blood pressure

Author

Xiaojie Xie, Fangkun Yang, Zhuo Wang, Jinlian Shen, Qinyi Bao, and Menghuai Ma

Subjects
chemistry.chemical_classification, medicine.medical_specialty, business.industry, Linoleic acid, General Medicine, Eicosapentaenoic acid, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Blood pressure, Endocrinology, chemistry, Docosahexaenoic acid, 030220 oncology & carcinogenesis, Internal medicine, Mendelian randomization, Medicine, lipids (amino acids, peptides, and proteins), Arachidonic acid, 030212 general & internal medicine, Docosapentaenoic acid, business, Polyunsaturated fatty acid
Abstract

High polyunsaturated fatty acids (PUFAs) intake is recommended for primary and secondary prevention of cardiovascular disease (CVD). However, the association of PUFAs with blood pressure (BP) is still controversial. In the present study, two-sample Mendelian randomization (MR) analysis was performed to investigate the causal relationship of PUFAs with BP, including systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP).Genetic instruments and summary statistics for two-sample MR analysis were obtained from 3 large-scale genome-wide association studies (GWASs). Eight single nucleotide polymorphisms (SNPs) significantly (P

Published
2021
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