1. Recent advances in paper‐based preconcentrators by utilizing ion concentration polarization
- Author
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Yuan Xichen, Ren Li, Shang Peng, Feng Huicheng, Meng Zhiyue, and Yang Yang
- Subjects
Chip fabrication ,Computer science ,Microfluidics ,010401 analytical chemistry ,Clinical Biochemistry ,Nanotechnology ,02 engineering and technology ,Ion concentration polarization ,Paper based ,Microfluidic Analytical Techniques ,021001 nanoscience & nanotechnology ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Analytical Chemistry ,Polarization phenomenon ,High complexity ,0210 nano-technology ,Polarization (electrochemistry) - Abstract
One of the most cited limitations of biochemical detection is its poor sensitivity, owing to the relatively high complexity of micro-samples. Moreover, some samples cannot be easily self-replicated and their abundance cannot be increased through traditional technologies. Therefore, the preconcentration of low-abundance samples is a key requirement for microfluidic biological analysis. In recent years, the ion-concentration polarization phenomenon has aroused widespread interest in the application of microfluidic technology. In addition, paper-based materials are readily available, easy to modify, and exhibit good hydrophilicity. The study of the ion-concentration polarization preconcentration of micro-samples in paper-based microfluidic chips is of considerable significance. In this review, we discuss the development and applications of ion-concentration polarization paper-based preconcentrator in the past 5 years, with emphasis on key progresses in chip fabrication and performance optimization under different conditions. The current needs and development prospects in this field have also been discussed.
- Published
- 2021