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11. Preparation and X-ray shielding properties of bismuth oxide/polyacrylonitrile composite nanofiber film by electrospinning.

Author

CHEN Jingjing, MENG Shengnan, LIU Hongling, SI Yang, YU Jianyong, and DING Bin

Subjects
POLYACRYLONITRILES, BISMUTH trioxide, BISMUTH oxides, MASS attenuation coefficients, RADIOGRAPHIC films, X-rays
Abstract

The bismuth oxide/polyacrylonitrile (Bi2O3/PAN) composite nanofiber film was prepared by electrospinning technology to explore the preparation process of the film and its X-ray protection performance. During the preparation process, we took polyethylene glycol (PEG) as dispersant and PAN as polymer, then dispersed Bi2O3 into the polymer solution. The effect of Bi2O3 content on the morphology, mechanical properties and X-ray protection of the film were investigated. The results indicate that the nanofiber film with light weight (0.21 g/cm³ density), uniform particle dispersion and good fiber morphology can be obtained by electrostatic spinning and drying at 60 °C for 2 h, at the mass percentage of Bi2O3 and PAN of 160%. The nanofiber film has good X-ray protection effect, with X-ray attenuation efficiency above 50% during the tube voltage rising from 20 kV to 120 kV, and the mass attenuation coefficient reaching 62.16 cm²/g under the voltage of 20 kV. It has great significance for the development of X-ray protection materials with lead-free, lightweight and high shielding efficiency. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase

Author

Dong Ruoyao, Yasong Ding, Meng Shengnan, Shiqi Wang, Hongyun Wang, and Lingdi Yin

Subjects
medicine.medical_specialty, NF-E2-Related Factor 2, Asparagine synthetase, Rats, Sprague-Dawley, chemistry.chemical_compound, Liver Function Tests, AMP-activated protein kinase, Internal medicine, Lactate dehydrogenase, Diabetes mellitus, medicine, Animals, Canagliflozin, Carbon Tetrachloride, Sodium-Glucose Transporter 2 Inhibitors, Pharmacology, Liver injury, biology, business.industry, Adenylate Kinase, AMPK, Aspartate-Ammonia Ligase, General Medicine, medicine.disease, Activating Transcription Factor 4, Rats, Disease Models, Animal, Endocrinology, Liver, chemistry, Carbon tetrachloride, biology.protein, Liver function, Chemical and Drug Induced Liver Injury, business
Abstract

Introduction: Canagliflozin (CANA) is a sodium-glucose cotransporter 2 inhibitor that was recently approved for treating diabetes. However, its effects on liver function are not well understood. The function of asparagine synthetase (ASNS) has been studied in several cancers but not in liver injury. Therefore, we investigated the connection between CANA and ASNS in alleviating damage (i.e., their hepatoprotective effect) in a rat liver injury model. Methods: The rat model of liver injury was established using carbon tetrachloride treatment. Rats with liver injury were administered CANA orally for 8 weeks daily. After week 8, peripheral blood was collected to measure serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase levels. Liver histopathology was examined using hematoxylin and eosin staining to determine the degree of liver injury. Protein expression in the rat livers was examined using Western blotting. Results: CANA treatment decreased serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase levels compared with those of the untreated group, demonstrating diminished liver injury. Mechanistically, CANA treatment activated AMP-activated protein kinase (AMPK), leading to increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and activating transcription factor 4 (ATF4), which upregulated ASNS expression in liver-injured rats. Conclusion: CANA significantly alleviated liver injury by activating the AMPK/Nrf2/ATF4 axis and upregulating ASNS expression, indicating its potential for treating patients with type 2 diabetes mellitus with impaired liver function.

Published
2021
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