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31 results on '"Meng, Guang-Xiao"'

13. CTNNB1-mutation-related immune gene prognostic model (CMRIPM) for hepatocellular carcinoma: Development and validation

Author

Li, Rui-Zhe, primary, Ding, Zi-Niu, additional, Meng, Guang-Xiao, additional, Liu, Hui, additional, Xue, Jun-Shuai, additional, Yan, Lun-Jie, additional, Dong, Zhao-Ru, additional, Hong, Jian-Guo, additional, Chen, Zhi-Qiang, additional, Tian, Bao-Wen, additional, Han, Cheng-Long, additional, Wang, Dong-Xu, additional, and Li, Tao, additional

Published
2023
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14. Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis

Author

Liu, Hui, primary, Han, Cheng-Long, additional, Tian, Bao-Wen, additional, Ding, Zi-Niu, additional, Yang, Ya-Fei, additional, Ma, Yun-Long, additional, Yang, Chun-Cheng, additional, Meng, Guang-Xiao, additional, Xue, Jun-Shuai, additional, Wang, Dong-Xu, additional, Dong, Zhao-Ru, additional, Chen, Zhi-Qiang, additional, Hong, Jian-Guo, additional, and Li, Tao, additional

Published
2023
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15. Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis

Author

Liu, Hui, Han, Cheng-Long, Tian, Bao-Wen, Ding, Zi-Niu, Yang, Ya-Fei, Ma, Yun-Long, Yang, Chun-Cheng, Meng, Guang-Xiao, Xue, Jun-Shuai, Wang, Dong-Xu, Dong, Zhao-Ru, Chen, Zhi-Qiang, Hong, Jian-Guo, and Li, Tao

Subjects
Hepatology, Gastroenterology
Abstract

Tenofovir (TDF) and entecavir (ETV) are first-line treatments for patients with chronic hepatitis B virus (HBV) infection. However, the effect of TDF versus ETV on the prognosis of HBV-related hepatocellular carcinoma (HCC) has not been fully clarified yet. PubMed, Embase and Web of science were searched up to March, 2021. Meta-analyses were performed for overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) to assess the effect of TDF versus ETV on the prognosis of HBV-related HCC. A total of 10 studies comprising 4706 Asian patients were included. The pooled results revealed that TDF was associated with better OS (adjusted HR = 0.50, 95% CI: 0.40–0.62; I2 = 36.0%, p = 0.167) and better RFS/DFS (adjusted HR = 0.70, 95% CI: 0.55–0.89, I2 = 71.9%, p = 0.002) than ETV in treatment of HBV-related HCC. Subgroup analysis revealed that OS benefit from TDF was generally consistent, except for patients who underwent non-surgical treatment for HCC. Subgroup analysis also indicated that TDF reduces the risk of late recurrence (HR = 0.41, 95% CI: 0.18–0.0.93; I2 = 63.0%, p = 0.067) rather than early recurrence (HR = 0.99, 95% CI: 0.64–1.52; I2 = 61.3%, p = 0.076). Compared with ETV, TDF has the advantage of improving OS and reducing late recurrence of patients with HBV-related HCC patients who underwent resection.

Published
2023
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16. Early alpha-fetoprotein response predicts prognosis of immune checkpoint inhibitor and targeted therapy for hepatocellular carcinoma: a systematic review with meta-analysis

Author

Tian, Bao-Wen, primary, Yan, Lun-Jie, additional, Ding, Zi-Niu, additional, Liu, Hui, additional, Meng, Guang-Xiao, additional, Xue, Jun-Shuai, additional, Han, Cheng-Long, additional, Dong, Zhao-Ru, additional, Hong, Jian-Guo, additional, Chen, Zhi-Qiang, additional, Wang, Dong-Xu, additional, and Li, Tao, additional

Published
2022
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19. The Prognostic Value of Natural Killer Cells and Their Receptors/Ligands in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Author

Xue, Jun-Shuai, primary, Ding, Zi-Niu, additional, Meng, Guang-Xiao, additional, Yan, Lun-Jie, additional, Liu, Hui, additional, Li, Hai-Chao, additional, Yao, Sheng-Yu, additional, Tian, Bao-Wen, additional, Dong, Zhao-Ru, additional, Chen, Zhi-Qiang, additional, Hong, Jian-Guo, additional, Wang, Dong-Xu, additional, and Li, Tao, additional

Published
2022
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20. The Association of Glycemic Index, Glycemic Load, and Daily Carbohydrates Intake with the Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

Author

Yang, Long-Shan, Yan, Lun-Jie, Meng, Guang-Xiao, Ding, Zi-Niu, Yao, Sheng-Yu, Li, Hai-Chao, Dong, Zhao-Ru, Chen, Zhi-Qiang, Hong, Jian-Guo, and Li, Tao

Subjects
ONLINE information services, META-analysis, MEDICAL information storage & retrieval systems, CONFIDENCE intervals, FOOD consumption, SYSTEMATIC reviews, CARBOHYDRATE content of food, CASE-control method, HEPATITIS viruses, GLYCEMIC index, RISK assessment, CARBOHYDRATES, RESEARCH funding, MEDLINE, ODDS ratio, HEPATOCELLULAR carcinoma, LONGITUDINAL method, DISEASE risk factors
Abstract

Background: Glycemic index (GI), glycemic load (GL) and daily carbohydrates intake have been associated with a variety of cancers, but their implications in hepatocellular carcinoma (HCC) remain controversial. The purpose of our study is to investigate the association of GI, GL and daily carbohydrates intake with the risk of HCC. Methods: Systematic searches were conducted in PubMed, Embase and Web of Science until November 2020. According to the degree of heterogeneity, random effect model or fixed effect model was chosen to obtain the pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs). Results: Four cohort studies and three case-control studies were eventually included. The pooled results showed no significant association of GI (RR = 1.11, 95% CI = 0.80-1.53), GL (RR = 1.09, 95% CI = 0.76-1.55), and daily carbohydrates intake (RR = 1.09, 95% CI = 0.84-1.32) with the risk of HCC in the general population. Subgroup analysis revealed that in hepatitis B virus (HBV) or/and hepatitis C virus (HCV)-positive group, GI was irrelevant to the risk of HCC (RR = 0.65, 95% CI = 0.32-1.32), while a high GL diet was associated with a higher risk of HCC (RR = 1.52, 95% CI = 1.04-2.23). In contrast, in HBV and HCV-negative group, both GI (RR = 1.23, 95% CI = 0.88-1.70) and GL (RR = 1.17, 95% CI = 0.83-1.64) were not associated with the risk of HCC. Conclusion: A high GL diet increases the risk of HCC in those with viral hepatitis. A low GL diet is recommended for them to reduce the risk of HCC. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Early alpha-fetoprotein response predicts prognosis of immune checkpoint inhibitor and targeted therapy for hepatocellular carcinoma: a systematic review with meta-analysis.

Author

Tian, Bao-Wen, Yan, Lun-Jie, Ding, Zi-Niu, Liu, Hui, Meng, Guang-Xiao, Xue, Jun-Shuai, Han, Cheng-Long, Dong, Zhao-Ru, Hong, Jian-Guo, Chen, Zhi-Qiang, Wang, Dong-Xu, and Li, Tao

Subjects
ALPHA fetoproteins, IMMUNE checkpoint inhibitors, HEPATOCELLULAR carcinoma, SURVIVAL rate, OVERALL survival, PROGNOSIS
Abstract

The prognostic value of alpha-fetoprotein (AFP) response for efficacy of targeted therapy or immune checkpoint inhibitors (ICIs) has not been established. The purpose of this meta-analysis is to elucidate the relationship between AFP response and survival outcomes in hepatocellular carcinoma (HCC) patients who received targeted therapy or ICIs. The hazard ratio (HR) with 95% confidence interval (CI) was used to evaluate the relationship between AFP response and overall survival (OS)/progression-free survival (PFS). Twenty-six articles containing 3056 HCC patients were finally included in the study. The pooled results showed that after targeted therapy or ICIs, patients with decrease in AFP had better prognosis (OS:HR = 0.48, 95%CI:0.40–0.56; PFS:HR = 0.39, 95%CI:0.33–0.46), while patients with increase in AFP had worse prognosis (OS:HR = 2.30, 95%CI:1.82–2.89; PFS:HR = 2.34, 95%CI = 1.69–3.24). Subgroup analysis revealed that compared to AFP decrease >50%, AFP decrease >20% can better predict the prognosis of patients who received targeted therapy (OS:HR = 0.51, 95%CI:0.41–0.62; PFS:HR = 0.39, 95%CI:0.30–0.51) or ICIs treatment (OS:HR = 0.34, 95%CI:0.16–0.71; PFS:HR = 0.22, 95%CI:0.10–0.47), and 8 weeks after targeted therapy may be the appropriate time point for AFP assessment. AFP decrease >20% within 8 weeks may be the appropriate definition for early AFP response which probably works best in predicting the efficacy of therapy. The review was not registered. [ABSTRACT FROM AUTHOR]

Published
2023
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22. The Predictive Potential of the Baseline C-Reactive Protein Levels for the Efficiency of Immune Checkpoint Inhibitors in Cancer Patients: A Systematic Review and Meta-Analysis

Author

Han, Cheng-Long, primary, Meng, Guang-Xiao, additional, Ding, Zi-Niu, additional, Dong, Zhao-Ru, additional, Chen, Zhi-Qiang, additional, Hong, Jian-Guo, additional, Yan, Lun-Jie, additional, Liu, Hui, additional, Tian, Bao-Wen, additional, Yang, Long-Shan, additional, Xue, Jun-Shuai, additional, and Li, Tao, additional

Published
2022
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25. Somatic mutation and expression of BAP1 in hepatocellular carcinoma: an indicator for ferroptosis and immune checkpoint inhibitor therapies

Author

Yan, Yu-Chuan, primary, Meng, Guang-Xiao, additional, Ding, Zi-Niu, additional, Liu, Yan-Feng, additional, Chen, Zhi-Qiang, additional, Yan, Lun-Jie, additional, yang, Ya-Fei, additional, Liu, Hui, additional, Yang, Chun-Cheng, additional, Dong, Zhao-Ru, additional, Hong, Jian-Guo, additional, and Li, Tao, additional

Published
2022
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26. Role of Rab GTPases in Hepatocellular Carcinoma

Author

Yang,Chun-Cheng, Meng,Guang-Xiao, Dong,Zhao-Ru, and Li,Tao

Subjects
digestive system diseases, Journal of Hepatocellular Carcinoma
Abstract

Chun-Cheng Yang,1,* Guang-Xiao Meng,1,* Zhao-Ru Dong,1,* Tao Li1,2 1Department of General Surgery, Qilu Hospital, Shandong University, Jinan, People’s Republic of China; 2Department of Hepatobiliary Surgery, The Second Hospital of Shandong University, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tao Li Tel +86-531-82166651Email litao7706@163.comAbstract: The Rab GTPase family contains almost 70 genes in the human genome and acts as the key regulator of intracellular membrane trafficking in human cells. The dysregulation of Rab GTPase has been shown to be associated with multiple human diseases, ranging from neurodegeneration, and infection to cancer. Rab GTPases not only play important roles in genome replication, morphogenesis and the release of hepatitis B virus (HBV) or hepatitis C virus (HCV), but also contribute to hepatitis-related hepatocarcinogenesis and hepatocellular carcinoma (HCC) progression. The alteration of Rab GTPase expression in HCC plays an important role in tumour cell proliferation, invasion and migration. Notably, the expression of Rab genes can be regulated by some noncoding RNAs, such as miRNAs and circRNAs. Thus, Rab GTPases can serve as promising rational and therapeutic targets for HCC treatments. In this review, we summarized recent advancements in this field focusing on Rab GTPases in HCC.Keywords: Rab GTPase, membrane trafficking, hepatocellular carcinoma, therapeutic target

Published
2021

28. Prognostic value of soluble programmed cell death-1 (sPD-1) and soluble programmed cell death ligand-1 (sPD-L1) for hepatocellular carcinoma: a systematic review and meta-analysis

Author

Xue, Jun-shuai, primary, Liu, Hui, additional, Meng, Guang-Xiao, additional, Ding, Zi-Niu, additional, Yan, Lun-Jie, additional, Yao, Sheng-Yu, additional, Li, Hai-Chao, additional, Dong, Zhao-Ru, additional, Chen, Zhi-Qiang, additional, Hong, Jian-Guo, additional, and Li, Tao, additional

Published
2021
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30. Gender Differences and Regional Disparities of Incidence of Hepatocellular Carcinoma in Autoimmune Hepatitis Patients: A Systematic Review and Meta-Analysis

Author

Yan, Lun-Jie, primary, Yao, Sheng-Yu, additional, Meng, Guang-Xiao, additional, Liu, Kai-Xuan, additional, Dong, Zhao-Ru, additional, Hong, Jian-Guo, additional, Li, Hai-Chao, additional, Yang, Ya-Fei, additional, Yan, Yu-Chuang, additional, Ding, Zi-Niu, additional, and Li, Tao, additional

Published
2021
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31. RECK expression is associated with angiogenesis and immunogenic Tumor Microenvironment in Hepatocellular Carcinoma, and is a prognostic factor for better survival

Author

Dong, Zhao-Ru, primary, Chen, Zhi-Qiang, additional, Yang, Xiao-Yun, additional, Ding, Zi-Niu, additional, Liu, Kai-Xuan, additional, Yan, Lun-Jie, additional, Meng, Guang-Xiao, additional, yang, Ya-Fei, additional, Yan, Yu-Chuan, additional, Yao, Sheng-Yu, additional, Yang, Chun-Cheng, additional, Zhi, Xu-Ting, additional, and Li, Tao, additional

Published
2021
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