Search

Your search keyword '"Meng, Fanling"' showing total 518 results
Start Over Author "Meng, Fanling"
518 results on '"Meng, Fanling"'

23. Identifying Active Sites of Pt‐NiFe LDH Catalysts for CO Oxidation Using In‐Situ DRIFTS with Multiple Microscopy and Spectroscopy Techniques.

Author

Liang, Qing, Li, Wenwen, Meng, Fanling, Song, Kexin, Feng, Yu, Liu, Yuhua, Liu, Meiqi, Huang, Chengxiang, Tao, Youkun, Chen, Zhongjun, Shao, Jing, and Zhang, Wei

Subjects
NEAR infrared reflectance spectroscopy, REFLECTANCE spectroscopy, FOURIER transform infrared spectroscopy, LAYERED double hydroxides, CATALYSTS, OXIDATION, DENSITY functional theory
Abstract

Layered double hydroxide (LDH) nanostructures are commonly used to study the interfacial effects of Pt‐based catalysts in CO oxidation. However, the specific role and detailed intermediates involved in CO oxidation remain unclear. Density functional theory (DFT) predicted that NiFe LDH loaded with single Pt atoms would exhibit satisfactory CO oxidation activity. On this basis, we prepared Pt1NiFe LDH catalysts with various Fe : Ni ratios by using the one‐pot method and achieved favorable dispersion of single Pt atoms. Pt1/FN‐1, which had the optimal Fe : Ni ratio (1 : 1), exhibited satisfactory catalytic performance for CO oxidation and a high turnover frequency, as determined through DFT calculations and experimental characterization. In‐situ diffuse reflectance infrared Fourier transform spectroscopy confirmed that CO directly reacted with Pt1/FN‐1 to produce CO2 and that introduced O2 formed bicarbonate species to produce CO2 together with the adsorbed CO on Pt1 sites. Overall, our work provides new insights into the catalytic mechanism of the well‐known Pt1NiFe LDH catalysts in CO oxidation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

28. Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide*

Author

Lee, Christine C, Julian, Mark C, Tiller, Kathryn E, Meng, Fanling, DuConge, Sarah E, Akter, Rehana, Raleigh, Daniel P, and Tessier, Peter M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Dementia, Acquired Cognitive Impairment, Neurodegenerative, Brain Disorders, Aging, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Amino Acid Substitution, Amyloid beta-Peptides, Binding Sites, Antibody, Complementarity Determining Regions, Humans, Islet Amyloid Polypeptide, Mutation, Missense, Peptide Fragments, Single-Chain Antibodies, aggregation, amyloid-beta, antibody engineering, conformation-specific, fibril, islet amyloid polypeptide, monomer, oligomer, protein stability, solubility, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences
Abstract

Antibodies with conformational specificity are important for detecting and interfering with polypeptide aggregation linked to several human disorders. We are developing a motif-grafting approach for designing lead antibody candidates specific for amyloid-forming polypeptides such as the Alzheimer peptide (Aβ). This approach involves grafting amyloidogenic peptide segments into the complementarity-determining regions (CDRs) of single-domain (VH) antibodies. Here we have investigated the impact of polar mutations inserted at the edges of a large hydrophobic Aβ42 peptide segment (Aβ residues 17-42) in CDR3 on the solubility and conformational specificity of the corresponding VH domains. We find that VH expression and solubility are strongly enhanced by introducing multiple negatively charged or asparagine residues at the edges of CDR3, whereas other polar mutations are less effective (glutamine and serine) or ineffective (threonine, lysine, and arginine). Moreover, Aβ VH domains with negatively charged CDR3 mutations show significant preference for recognizing Aβ fibrils relative to Aβ monomers, whereas the same VH domains with other polar CDR3 mutations recognize both Aβ conformers. We observe similar behavior for a VH domain grafted with a large hydrophobic peptide from islet amyloid polypeptide (residues 8-37) that contains negatively charged mutations at the edges of CDR3. These findings highlight the sensitivity of antibody binding and solubility to residues at the edges of CDRs, and provide guidelines for designing other grafted antibody fragments with hydrophobic binding loops.

Published
2016

45. Metal-matrix composite fabricated with gas tungsten arc melt injection and precoated with NiCrBSi alloy to increase the volume fraction of WC particles

Author

Liu Aiguo, Li Da, Meng Fanling, and Sun Huanhuan

Subjects
gas tungsten arc melt injection, metal-matrix composite, nicrbsi alloy coating, volume fraction, wc particle, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

The volume fraction, dissolution, and segregation of WC particles in metal-matrix composites (MMCs) are critical to their wear resistance. Low carbon steel substrates were precoated with NiCrBSi coatings and processed with gas tungsten arc melt injection method to fabricate MMCs with high volume fraction of WC particles. The microstructures and wear resistance of the composites were investigated. The results showed that the volume fraction of WC particles increased with decreasing hopper height and was as high as 44% when hopper height was 100 mm. The dissolution of WC particles was minimal. The content of the alloying elements decreased from the top to the bottom of the matrix. More WC particles dissolved in the overlapping area, where Fe3W3C carbide blocks could be found. The wear loss of the MMCs after 40 min was 6.9 mg, which is 76 times less than that of the substrate after the 4 min test.

Published
2017
Full Text
View/download PDF

49. Targeted Computed Tomography Visualization and Healing of Inflammatory Bowel Disease by Orally Delivered Bacterial-Flagella-Inspired Polydiiododiacetylene Nanofibers

Author

Yin, Mingming, primary, Chen, Yu, additional, Liu, Xiaoming, additional, Tian, Sidan, additional, Zhao, Liyuan, additional, Bai, Yaowei, additional, Wang, Hao, additional, Lin, Jinfeng, additional, Jiang, Dawei, additional, Lei, Ziqiao, additional, Meng, Fanling, additional, Tian, De’an, additional, and Luo, Liang, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results