1. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase.
- Author
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Pan Z, Scheerens H, Li SJ, Schultz BE, Sprengeler PA, Burrill LC, Mendonca RV, Sweeney MD, Scott KC, Grothaus PG, Jeffery DA, Spoerke JM, Honigberg LA, Young PR, Dalrymple SA, and Palmer JT
- Subjects
- Adenosine Triphosphate metabolism, Agammaglobulinaemia Tyrosine Kinase, Amino Acid Sequence, Animals, Antirheumatic Agents chemistry, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid enzymology, Binding Sites, Disease Models, Animal, Molecular Sequence Data, Oligopeptides chemistry, Oligopeptides metabolism, Protein Kinase Inhibitors chemistry, Protein Kinase Inhibitors therapeutic use, Protein-Tyrosine Kinases metabolism, Rodentia, Structure-Activity Relationship, Antirheumatic Agents pharmacology, Drug Design, Protein Kinase Inhibitors pharmacology, Protein-Tyrosine Kinases antagonists & inhibitors
- Published
- 2007
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