382 results on '"Mendis, S."'
Search Results
2. Remedy or tragedy: Acalypha indica -induced acute oxidative hemolysis associated with acute kidney injury and infective endocarditis: An initial presentation of G6PD Deficiency: A case report.
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Charles, J.C., Kiriwandeniya, K.G.K.U., Liyanapathirana, K.V., Gunarathna, R.D.S., Mendis, S., and Liyanarachchi, G.G.
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- 2024
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3. Are low-and-middle-income countries using scarce resources effectively to tackle noncommunicable diseases in the pandemic era?
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Mendis, S., primary
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- 2023
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4. Synthesis, Characterization of Bio-based Polyol and Assess the Effectiveness of Bio-based Polyurethane Direct-to-metal Coating System
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Mendis, S. Sameera D., primary
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- 2023
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5. Introduzione : La malattia cardiaca e i fattori psicosociali
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Mendis, S., Molinari, Enrico, Parati, Gianfranco, and Compare, Angelo
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- 2007
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6. A case report of melioidosis complicated by infective sacroiliitis in Sri Lanka
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Karunarathna, A. K. T. M., Mendis, S. A., Perera, W. P. D. P., Patabendige, Geethika, Pallewatte, A. S., and Kulatunga, Aruna
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- 2018
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7. Introduction: Heart Disease and Psychosocial Factors
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Mendis, S., Molinari, Enrico, Parati, Gianfranco, and Compare, Angelo
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- 2006
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8. Treatment and outcomes of unresectable and metastatic pancreatic cancer treated in public and private Australian hospitals
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To, YH, Shapiro, J, Wong, R, Thomson, B, Nagrial, A, Mendis, S, Gibbs, P, Lee, B, To, YH, Shapiro, J, Wong, R, Thomson, B, Nagrial, A, Mendis, S, Gibbs, P, and Lee, B
- Abstract
BACKGROUND: Prior studies have reported for several cancer types that treatment in the private sector is associated with improved survival outcomes. Data for patients with locally advanced unresectable and metastatic pancreatic ductal adenocarcinoma (PDAC) have not previously been reported. METHODS: Analysis of patients from January 2016 to June 2020 registered to a multicentre prospective cancer database. Baseline demographic and clinicopathologic characteristics were compared. The Kaplan-Meier method was used to compare overall survival (OS). Multivariate Cox and logistic regression analyses were used to determine predictors of mortality and first-line chemotherapy treatment, respectively. RESULTS: Of 822 patients, 22.5% received private care. Private patients were older (median 71.5 vs. 68.9 years, p ≤ .05), had better performance status (ECOG 0 to 1: 82.2 vs. 73.5%, p = .05) and more likely to reside in an area with high socioeconomic advantage (67.0 vs. 19.6%, p ≤ .01). Private patients were more likely to receive first-line chemotherapy (69.7 vs. 54.2%, p ≤ .01) with logistic regression demonstrating private care (OR: 1.87, 95% CI: 1.20 to 2.97) as an independent predictor of receiving chemotherapy. Private patients had prolonged survival (median OS: 9.2 vs. 6.9 months, HR 1.2, p = .05). Receiving first-line chemotherapy was an independent predictor of mortality, but private care was not. CONCLUSIONS: Care in the private system is associated with improved OS, with higher uptake of first-line chemotherapy appearing to be the main contributor. Given the discrepancy, further studies are needed to determine what factors are driving this difference.
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- 2022
9. Biology and Clinical Implications of Fecal Occult Blood Test Screen-Detected Colorectal Cancer
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Mendis, S, Hong, W, Ananda, S, Faragher, I, Jones, I, Croxford, M, Steel, M, Jalali, A, Gard, G, To, YH, Lee, M, Kosmider, S, Wong, R, Tie, J, Gibbs, P, Mendis, S, Hong, W, Ananda, S, Faragher, I, Jones, I, Croxford, M, Steel, M, Jalali, A, Gard, G, To, YH, Lee, M, Kosmider, S, Wong, R, Tie, J, and Gibbs, P
- Abstract
BACKGROUND: Fecal occult blood test (FOBT)-based screening for colorectal cancer (CRC) reduces mortality, with earlier stage at diagnosis a prominent feature. Other characteristics of FOBT screen-detected cancers and any implications for clinical management have not been well explored. METHODS: We examined a multisite clinical registry to compare the characteristics and outcomes of FOBT screen-detected CRC via the Australian National Bowel Cancer Screening Program (NBCSP), which is offered biennially to individuals aged 50-74 years, and age-matched non-screen-detected CRC in the same registry. All statistical tests were 2-sided. Odds ratios (ORs) were calculated using the Baptista-Pike method, and hazard ratios via the log-rank method. RESULTS: Of 7153 registry patients diagnosed June 1, 2006, to June 30, 2020, 4142 (57.9%) were aged between 50 and 74 years. Excluding 406 patients with non-NBCSP screen-detected cancers and 35 patients with unknown method of detection, 473 (12.8%) were screen detected via the NBCSP, and 3228 (87.2%) were non-screen detected. Screen-detected patients were younger (mean age = 62.4 vs 64.2 years; P < .001) and more medically fit (OR for ASA score 1-2 = 1.91, 95% confidence interval [CI] = 1.51 to 2.41; P < .001). Pathologic characteristics within each stage favored the screen-detected patients. Stage III screen-detected colon cancers were more likely to receive adjuvant therapy (OR = 3.58, 95% CI = 1.52 to 8.36; P = .002). Screen-detected patients had superior relapse-free (hazard ratio = 0.41, 95% CI = 0.29 to 0.60; P < .001) and overall survival (hazard ratio = 0.22, 95% CI = 0.15 to 0.35; P < .001), which was maintained in matched stage comparisons and multivariable analysis. CONCLUSIONS: Beyond stage at diagnosis, multiple other factors associated with a favorable outcome are observed in FOBT screen-detected CRC. Given the substantial stage-by-stage differences in survival outcomes, if independently confirmed, individualized adjuvan
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- 2022
10. The global response for prevention and control of chronic non-communicable diseases: key milestones and outcomes.
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Mendis, S., primary and Chestnov, O., additional
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- 2015
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11. The role of cardiovascular risk assessment in addressing prevention of cardiovascular disease and cardiovascular complications of diabetes in South Asia
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Mendis, S., primary
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- 2022
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12. Synthesis, Characterization and Application of BioBased Plasticizers in Quality Improvement of Nitrocellulose Surface Coatings
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D. Mendis, S. Sameera, primary and Nilmini, A.H.L.R, additional
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- 2022
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13. Learning approach among health sciences students in a medical college in Nepal: a cross-sectional study
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Gopakumar A, Mendis S, Muttappallymyalil J, and Sreedharan J
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Learning approach ,Deep approach ,Surface approach ,Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
Aji Gopakumar,1 Susirith Mendis,2 Jayakumary Muttappallymyalil,3 Jayadevan Sreedharan3 1Department of General Education, 2Continuing Medical Education, Continuing Professional Development and Center for Continuing Education and Community Outreach, 3Department of Community Medicine, Gulf Medical University, Ajman, United Arab Emirates Shah et al aimed to explore the learning approaches among medical, dental, and nursing students which were considered useful to transform the students to become better learners. While the generic objective of the study is appreciated, we have some concerns regarding the methodology and statistical analysis of the study. View the original paper by Author and colleagues.
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- 2016
14. Acute ischemic strokes due to bites by Daboia russelii in Sri Lanka – First authenticated case series
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Gawarammana, I., Mendis, S., and Jeganathan, K.
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- 2009
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15. Hepatobiliary and Pancreatic: Liver lesions in cirrhosis: When to biopsy?
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Gazelakis, K, primary, Mendis, S, additional, Wang, S, additional, Wong, S, additional, Lovett, G, additional, and Valaydon, Z, additional
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- 2021
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16. Psoas abscess caused by probable extended spectrum beta lactamase (ESBL) producing Escherichia coli: A Case Report
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Kumara, J. A. L. U., primary, Somasiri, G. W. D., additional, Mendis, D. M., additional, Wijesinghe, C. N., additional, Galagedara, W. D., additional, Abeygunasekara, A. M., additional, Mendis, S., additional, and Chandrasiri, N. S., additional
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- 2021
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17. The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation
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Simmons, R. K., Alberti, K. G. M. M., Gale, E. A. M., Colagiuri, S., Tuomilehto, J., Qiao, Q., Ramachandran, A., Tajima, N., Brajkovich Mirchov, I., Ben-Nakhi, A., Reaven, G., Hama Sambo, B., Mendis, S., and Roglic, G.
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- 2010
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18. Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk—a review of the literature
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Huxley, R, Mendis, S, Zheleznyakov, E, Reddy, S, and Chan, J
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- 2010
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19. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
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Ray, K, Colhoun, H, Szarek, M, Baccara-Dinet, M, Bhatt, D, Bittner, V, Budaj, A, Diaz, R, Goodman, S, Hanotin, C, Harrington, R, Jukema, J, Loizeau, V, Lopes, R, Moryusef, A, Murin, J, Pordy, R, Ristic, A, Roe, M, Tunon, J, White, H, Zeiher, A, Schwartz, G, Steg, P, Tricoci, P, Mahaffey, K, Edelberg, J, Lecorps, G, Sasiela, W, Tamby, J, Aylward, P, Drexel, H, Sinnaeve, P, Dilic, M, Gotcheva, N, Prieto, J, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Ostadal, P, Viigimaa, M, Nieminen, M, Chumburidze, V, Marx, N, Danchin, N, Liberopoulos, E, Montenegro Valdovinos, P, Tse, H, Kiss, R, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, H, Kim, S, Erglis, A, Laucevicius, A, Kedev, S, Yusoff, K, Ramos Lopez, G, Alings, M, Halvorsen, S, Correa Flores, R, Morais, J, Dorobantu, M, Karpov, Y, Chua, T, Fras, Z, Dalby, A, de Silva, H, Hagstrom, E, Landmesser, U, Chiang, C, Sritara, P, Guneri, S, Parkhomenko, A, Moriarty, P, Vogel, R, Chaitman, B, Kelsey, S, Olsson, A, Rouleau, J, Simoons, M, Alexander, K, Meloni, C, Rosenson, R, Sijbrands, E, Alexander, J, Armaganijan, L, Bagai, A, Bahit, M, Brennan, J, Clifton, S, Devore, A, Deloatch, S, Dickey, S, Dombrowski, K, Ducrocq, G, Eapen, Z, Endsley, P, Eppinger, A, Harrison, R, Hess, C, Hlatky, M, Jordan, J, Knowles, J, Kolls, B, Kong, D, Leonardi, S, Lillis, L, Maron, D, Marcus, J, Mathews, R, Mehta, R, Mentz, R, Moreira, H, Patel, C, Bernardez-Pereira, S, Perkins, L, Povsic, T, Puymirat, E, Schuyler Jones, W, Shah, B, Sherwood, M, Stringfellow, K, Sujjavanich, D, Toma, M, Trotter, C, Van Diepen, S, Wilson, M, Yan, A, Schiavi, L, Garrido, M, Alvarisqueta, A, Sassone, S, Bordonava, A, Alves De Lima, A, Schmidberg, J, Duronto, E, Caruso, O, Novaretto, L, Hominal, M, Montana, O, Caccavo, A, Gomez Vilamajo, O, Lorenzatti, A, Cartasegna, L, Paterlini, G, Mackinnon, I, Caime, G, Amuchastegui, M, Salomone, O, Codutti, O, Jure, H, Bono, J, Hrabar, A, Vallejos, J, Ahuad Guerrero, R, Novoa, F, Patocchi, C, Zaidman, C, Giuliano, M, Dran, R, Vico, M, Carnero, G, Guzman, P, Medrano Allende, J, Garcia Brasca, D, Bustamante Labarta, M, Nani, S, Blumberg, E, Colombo, H, Liberman, A, Fuentealba, V, Luciardi, H, Waisman, G, Berli, M, Garcia Duran, R, Cestari, H, Luquez, H, Giordano, J, Saavedra, S, Zapata, G, Costamagna, O, Llois, S, Waites, J, Collins, N, Soward, A, Hii, C, Shaw, J, Arstall, M, Horowitz, J, Ninio, D, Rogers, J, Colquhoun, D, Oqueli Flores, R, Roberts-Thomson, P, Raffel, O, Lehman, S, Aroney, C, Coverdale, S, Garrahy, P, Starmer, G, Sader, M, Carroll, P, Dick, R, Zweiker, R, Hoppe, U, Huber, K, Berger, R, Delle-Karth, G, Frey, B, Weidinger, F, Faes, D, Hermans, K, Pirenne, B, Leone, A, Hoffer, E, Vrolix, M, De Wolf, L, Wollaert, B, Castadot, M, Dujardin, K, Beauloye, C, Vervoort, G, Striekwold, H, Convens, C, Roosen, J, Barbato, E, Claeys, M, Cools, F, Terzic, I, Barakovic, F, Midzic, Z, Pojskic, B, Fazlibegovic, E, Kulic, M, Durak-Nalbantic, A, Vulic, D, Muslibegovic, A, Goronja, B, Reis, G, Sousa, L, Nicolau, J, Giorgeto, F, Silva, R, Nigro Maia, L, Rech, R, Rossi, P, Cerqueira, M, Duda, N, Kalil, R, Kormann, A, Abrantes, J, Pimentel Filho, P, Soggia, A, de Santos, M, Neuenschwander, F, Bodanese, L, Michalaros, Y, Eliaschewitz, F, Vidotti, M, Leaes, P, Botelho, R, Kaiser, S, Manenti, E, Precoma, D, Moura Jorge, J, de B Silva, P, Silveira, J, Saporito, W, Marin-Neto, J, Feitosa, G, Ritt, L, de Souza, J, Costa, F, Souza, W, Reis, H, Machado, L, Ayoub, J, Todorov, G, Nikolov, F, Velcheva, E, Tzekova, M, Benov, H, Petranov, S, Tumbev, H, Shehova-Yankova, N, Markov, D, Raev, D, Mollov, M, Kichukov, K, Ilieva-Pandeva, K, Ivanova, R, Gospodinov, M, Mincheva, V, Lazov, P, Dimov, B, Senaratne, M, Stone, J, Kornder, J, Pearce, S, Dion, D, Savard, D, Pesant, Y, Pandey, A, Robinson, S, Gosselin, G, Vizel, S, Hoag, G, Bourgeois, R, Morisset, A, Sabbah, E, Sussex, B, Kouz, S, Macdonald, P, Diaz, A, Michaud, N, Fell, D, Leung, R, Vuurmans, T, Lai, C, Nigro, F, Davies, R, Nogareda, G, Vijayaraghavan, R, Ducas, J, Lepage, S, Mehta, S, Cha, J, Dupuis, R, Fong, P, Lutchmedial, S, Rodes-Cabau, J, Fadlallah, H, Cleveland, D, Huynh, T, Bata, I, Hameed, A, Pincetti, C, Potthoff, S, Acevedo, M, Aguirre, A, Vejar, M, Yanez, M, Araneda, G, Fernandez, M, Perez, L, Varleta, P, Florenzano, F, Huidobro, L, Raffo, C, Olivares, C, Nahuelpan, L, Montecinos, H, Chen, J, Dong, Y, Huang, W, Wang, J, Huang, S, Yao, Z, Li, X, Cui, L, Lin, W, Sun, Y, Li, J, Zhang, X, Zhu, H, Chen, D, Huang, L, Dong, S, Su, G, Xu, B, Su, X, Cheng, X, Lin, J, Zong, W, Li, H, Feng, Y, Xu, D, Yang, X, Ke, Y, Lin, X, Zhang, Z, Zheng, Z, Luo, Z, Chen, Y, Ding, C, Zhong, Y, Zheng, Y, Peng, D, Zhao, S, Li, Y, Liu, X, Wei, M, Liu, S, Yu, Y, Qu, B, Jiang, W, Zhou, Y, Zhao, X, Yuan, Z, Guo, Y, Xu, X, Shi, X, Ge, J, Fu, G, Bai, F, Fang, W, Shou, X, Xiang, M, Lu, Q, Zhang, R, Zhu, J, Xu, Y, Fan, Z, Li, T, Wu, C, Jaramillo, N, Sanchez Vallejo, G, Luna Botia, D, Botero Lopez, R, Molina De Salazar, D, Cadena Bonfanti, A, Cotes Aroca, C, Diego Higuera, J, Blanquicett, M, Barrera Silva, S, Garcia Lozada, H, Coronel Arroyo, J, Accini Mendoza, J, Fernandez Ruiz, R, Quintero Ossa, A, Manzur Jatin, F, Sotomayor Herazo, A, Castellanos Parada, J, Suarez Arambula, R, Urina Triana, M, Fernandez Trujillo, A, Strozzi, M, Car, S, Jeric, M, Milicic, D, Bencic, M, Pintaric, H, Prvulovic, D, Sikic, J, Persic, V, Mileta, D, Stambuk, K, Babic, Z, Tomulic, V, Lukenda, J, Mejic-Krstulovic, S, Starcevic, B, Spinar, J, Horak, D, Velicka, Z, Stasek, J, Alan, D, Machova, V, Linhart, A, Novotny, V, Kaucak, V, Rokyta, R, Naplava, R, Coufal, Z, Adamkova, V, Podpera, I, Zizka, J, Motovska, Z, Marusincova, I, Svab, P, Heinc, P, Kuchar, J, Povolny, P, Matuska, J, Poulsen, S, Raungaard, B, Clemmensen, P, Bang, L, May, O, Bottcher, M, Hove, J, Frost, L, Gislason, G, Larsen, J, Betton Johansen, P, Hald, F, Johansen, P, Jeppesen, J, Nielsen, T, Kristensen, K, Walichiewicz, P, Lomholdt, J, Klausen, I, Nielsen, P, Davidsen, F, Videbaek, L, Soots, M, Vahula, V, Hedman, A, Soopold, U, Martsin, K, Jurgenson, T, Kristjan, A, Helsinki, J, Vikman, S, Huikuri, H, Airaksinen, J, Coste, P, Ferrari, E, Morel, O, Montalescot, G, Machecourt, J, Barone-Rochette, G, Mansourati, J, Cottin, Y, Leclercq, F, Belhassane, A, Delarche, N, Boccara, F, Paganelli, F, Clerc, J, Schiele, F, Aboyans, V, Probst, V, Berland, J, Lefevre, T, Citron, B, Khintibidze, I, Shaburishvili, T, Pagava, Z, Ghlonti, R, Lominadze, Z, Khabeishvili, G, Hemetsberger, R, Edward, K, Rauch-Krohnert, U, Stratmann, M, Appel, K, Schmidt, E, Omran, H, Stellbrink, C, Dorsel, T, Lianopoulos, E, Vohringer, H, Marx, R, Zirlik, A, Schellenberg, D, Heitzer, T, Laufs, U, Werner, C, Gielen, S, Nuding, S, Winkelmann, B, Behrens, S, Sydow, K, Karakas, M, Simonis, G, Muenzel, T, Werner, N, Leggewie, S, Bocker, D, Braun-Dullaeus, R, Toursarkissian, N, Jeserich, M, Weissbrodt, M, Schaeufele, T, Weil, J, Voller, H, Waltenberger, J, Natour, M, Schmitt, S, Muller-Wieland, D, Steiner, S, Heidenreich, L, Offers, E, Gremmler, U, Killat, H, Rieker, W, Patsilinakos, S, Kartalis, A, Manolis, A, Sionis, D, Chachalis, G, Skoumas, I, Athyros, V, Vardas, P, Parthenakis, F, Alexopoulos, D, Hahalis, G, Lekakis, J, Hatzitolios, A, Fausto Ovando, S, Arango Benecke, J, Rodriguez De Leon, E, Yan, B, Siu, D, Turi, T, Merkely, B, Ungi, I, Lupkovics, G, Nagy, L, Katona, A, Edes, I, Muller, G, Horvath, I, Kapin, T, Szigeti, Z, Falukozy, J, Kumbla, M, Sandhu, M, Annam, S, Proddutur, N, Regella, R, Premchand, R, Mahajan, A, Pawar, S, Abhyanakar, A, Kerkar, P, Govinda, R, Oomman, A, Sinha, D, Patil, S, Kahali, D, Sawhney, J, Joshi, A, Chaudhary, S, Harkut, P, Guha, S, Porwal, S, Jujjuru, S, Pothineni, R, Monteiro, M, Khan, A, Iyengar, S, Grewal, J, Chopda, M, Fulwani, M, Patange, A, Sachin, P, Chopra, V, Goyal, N, Shinde, R, Manakshe, G, Patki, N, Sethi, S, Munusamy, V, Karna, S, Thanvi, S, Adhyapak, S, Patil, C, Pandurangi, U, Mathur, R, Gupta, J, Kalashetti, S, Bhagwat, A, Raghuraman, B, Yerra, S, Bhansali, P, Borse, R, Rahul, P, Das, S, Kumar, V, Abdullakutty, J, Saathe, S, Palimkar, P, Sathe, S, Atar, S, Shechter, M, Mosseri, M, Arbel, Y, Ehud, C, Ofer, H, Lotan, C, Rosenschein, U, Katz, A, Henkin, Y, Francis, A, Klutstein, M, Nikolsky, E, Zukermann, R, Turgeman, Y, Halabi, M, Marmor, A, Kornowski, R, Jonas, M, Amir, O, Hasin, Y, Rozenman, Y, Fuchs, S, Zvi, V, Hussein, O, Gavish, D, Vered, Z, Caraco, Y, Elias, M, Tov, N, Wolfovitz, E, Lishner, M, Elias, N, Piovaccari, G, De Pellegrin, A, Garbelotto, R, Guardigli, G, Marco, V, Licciardello, G, Auguadro, C, Scalise, F, Cuccia, C, Salvioni, A, Musumeci, G, Senni, M, Calabro, P, Novo, S, Faggiano, P, Metra, M, De Cesare, N, Berti, S, Cavallini, C, Puccioni, E, Galvani, M, Tespili, M, Piatti, P, Palvarini, M, De Luca, G, Violini, R, De Leo, A, Olivari, Z, Perrone Filardi, P, Ferratini, M, Racca, V, Dai, K, Shimatani, Y, Kamiya, H, Ando, K, Takeda, Y, Morino, Y, Hata, Y, Kimura, K, Kishi, K, Michishita, I, Uehara, H, Higashikata, T, Hirayama, A, Hirooka, K, Doi, Y, Sakagami, S, Taguchi, S, Koike, A, Fujinaga, H, Koba, S, Kozuma, K, Kawasaki, T, Ono, Y, Shimizu, M, Katsuda, Y, Wada, A, Shinke, T, Ako, J, Fujii, K, Takahashi, T, Sakamoto, T, Nakao, K, Furukawa, Y, Sugino, H, Tamura, R, Mano, T, Uematsu, M, Utsu, N, Ito, K, Haraguchi, T, Sato, K, Ueda, Y, Nishibe, A, Fujimoto, K, Masutani, M, Yoon, J, Park, H, Chae, I, Kim, M, Jeong, M, Rha, S, Kim, C, Hong, T, Tahk, S, Kim, Y, Busmane, A, Pontaga, N, Strelnieks, A, Mintale, I, Sime, I, Petrulioniene, Z, Kavaliauskiene, R, Jurgaitiene, R, Sakalyte, G, Slapikas, R, Norkiene, S, Misonis, N, Kibarskis, A, Kubilius, R, Bojovski, S, Lozance, N, Kjovkaroski, A, Doncovska, S, Ong, T, Kasim, S, Maskon, O, Kandasamy, B, Liew, H, Wan Mohamed, W, Garcia Castillo, A, Carrillo Calvillo, J, Fajardo Campos, P, Nunez Fragoso, J, Bayram Llamas, E, Alcocer Gamba, M, Carranza Madrigal, J, Gonzalez Salas, L, Lopez Rosas, E, Gonzalez Diaz, B, Salcido Vazquez, E, Nacoud Ackar, A, Llamas Esperon, G, Martinez Sanchez, C, Guerrero De Leon, M, Suarez Otero, R, Fanghanel Salmon, G, Perez Rios, J, Garza Ruiz, J, Breedveld, R, Feenema-Aardema, M, Borger-Van Der Burg, A, Hoogslag, P, Suryapranata, H, Oomen, A, Van Haelst, P, Wiersma, J, Basart, D, Van Der Wal, R, Zwart, P, Monraats, P, Van Kesteren, H, Karalis, I, Verdel, G, Brueren, B, Troquay, R, Viergever, E, Al-Windy, N, Bartels, G, Cornel, J, Hermans, W, Herrman, J, Bos, R, Groutars, R, Van Der Zwaan, C, Kaplan, R, Lionarons, R, Ronner, E, Groenemeijer, B, Bronzwaer, P, Liem, A, Rensing, B, Bokern, M, Nijmeijer, R, Hersbach, F, Willems, F, Gosselink, A, Rasoul, S, Elliott, J, Wilkins, G, Fisher, R, Scott, D, Hart, H, Stewart, R, Harding, S, Ternouth, I, Fisher, N, Wilson, S, Aitken, D, Anscombe, R, Davidson, L, Tomala, T, Nygard, O, Sparby, J, Andersen, K, Gullestad, L, Jortveit, J, Munk, P, Singsaas, E, Hurtig, U, Calderon Ticona, J, Durand Velasquez, J, Negron Miguel, S, Sanabria Perez, E, Carrion 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A., Diaz Fernandez J. F., Garcia Lledo J. A., Cosin Sales J., Botas Rodriguez J., Gusi Tragant G., Benedicto A., Gonzalez-Juanatey C., Camprubi Potau M., Plaza Perez I., De La Tassa C. M., Loma-Osorio Rincon P., Balaguer Recena J., Escudier J. M., Payeras A. C., Alonso Orcajo N., Valdivielso P., Constantine G., Haniffa R., Tissera N., Amarasekera S., Ponnamperuma C., Fernando N., Fernando K., Jayawardena J., Wijeyasingam S., Ranasinghe G., Ekanayaka R., Mendis S., Senaratne V., Mayurathan G., Sirisena T., Rajapaksha A., Herath J. I., Amarasena N., Berglund S., Rasmanis G., Vedin O., Witt N., Mourtzinis G., Nicol P., Hansen O., Romeo S., Agergaard Jensen S., Torstensson I., Ahremark U., Sundelin T., Moccetti T., Muller C., Mach F., Binde R., Tsai W. -C., Ueng K. -C., Lai W. -T., Liu M. -E., Hwang J. -J., Yin W. -H., Hsieh I. -C., Hsieh M. -J., Lin W. H., Kuo J. -Y., Huang T. -Y., Fang C. -Y., Kaewsuwanna P., Soonfuang W., Jintapakorn W., Sukonthasarn A., Wongpraparut N., Sastravaha K., Sansanayudh N., Kehasukcharoen W., Piyayotai D., Chotnoparatpat P., Camsari A., Kultursay H., Mutlu B., Ersanli M., Demirtas M., Kirma C., Ural E., Koldas L., Karpenko O., Prokhorov A., Vakaluyk I., Myshanych H., Reshotko D., Batushkin V., Rudenko L., Kovalskyi I., Kushnir M., Tseluyko V., Mostovoy Y., Stanislavchuk M., Kyiak Y., Karpenko Y., Malynovsky Y., Klantsa A., Kutniy O., Amosova E., Tashchuk V., Leshchuk O., Rishko M., Kopytsya M., Yagensky A., Vatutin M., Bagriy A., Barna O. M., Ushakov O., Dzyak G., Goloborodko B., Rudenko A., Zheleznyy V., Trevelyan J., Zaman A., Lee K., Moriarty A., Aggarwal R. K., Clifford P., Wong Y. -K., Iqbal S. M., Subkovas E., Braganza D., Sarkar D., Storey R., Griffiths H., McClure S., Muthusamy R., Smith S., Kurian J., Levy T., Barr C., Kadr H., Gerber R., Simaitis A., Soran H., Mathur A., Brodison A., Ayaz M., Cheema M., Oliver R., Thackray S., Mudawi T., Rahman G., Sultan A., Sharman D., Sprigings D., Butler R., Wilkinson P., Lip G. Y., Halcox J., Gallagher S., Ossei-Gerning N., Vardi G., Baldari D., Brabham D., Treasure II C., Dahl C., Palmer B., Wiseman A., Puri S., Mohart A. E., Ince C., Flores E., Wright S., Cheng S. -C., Rosenberg M., Rogers W., Kosinski E., Forgosh L., Waltman J., Khan M., Shoukfeh M., Dagher G., Cambier P., Lieber I., Kumar P., East C., Krichmar P., Hasan M., White L., Knickelbine T., Haldis T., Gillespie E., Amidon T., Suh D., Arif I., Abdallah M., Akhter F., Carlson E., D'Urso M., El-Ahdab F., Nelson W., Moriarty K., Harris B., Cohen S., Carter L., Doty D., Sabatino K., Haddad T., Malik A., Rao S., Mulkay A., Jovin I., Klancke K., Malhotra V., Devarapalli S. K., Koren M., Chandna H., Dodds III G., Goraya T., Bengston J., Janik M., Moran J., Sumner A., Kobayashi J., Davis W., Yazdani S., Pasquini J., Thakkar M., Vedere A., Leimbach W., Rider J., Fenton S., Singh N., Shah A. V., Janosik D., Pepine C., Berman B., Gelormini J., Daniels C., Richard K., Keating F., Kondo N. I., Shetty S., Levite H., Waider W., Takata T., Abu-Fadel M., Shah V., Aggarwal R., Izzo M., Kumar A., Hattler B., Do R., Link C., Bortnick A., Kinzfogl III G., Ghitis A., Larry J., Teufel E., Kuhlman P., Mclaurin B., Zhang W., Thew S., Abbas J., White M., Islam O., Subherwal S., Ranadive N., Vakili B., Gring C., Henderson D., Schuchard T., Farhat N., Kline G., Mahal S., Whitaker J., Speirs S., Andersen R., Daboul N., Horwitz P., Zahr F., Ponce G., Jafar Z., Mcgarvey J., Panchal V., Voyce S., Blok T., Sheldon W., Azizad M. M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H. T., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G. T., Massey C., Wattanakit K., O'Donnell P. J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Marais H. J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A. S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W. J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F. M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P. S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker B., Gilbert J. M., Chalavarya G., Eaton C., Schmedtje J. F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. A., and McClanahan M. A.
- Abstract
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring
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- 2019
20. 1683TiP Trial in progress: NEO-adjuvant chemo-IMmunotherapy in PAnCreaTic cancer-NEO-IMPACT
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Maloney, S., Tebbutt, N., Nikfarjam, M., Samra, J., Mendis, S., Tie, J., Christopherson, L., Hayes, S., Berthon-Jones, N., Yim, C.H.H., El-Omar, E., and Chantrill, L.
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- 2023
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21. the current role of immunotherapy in gastrointestinal cancers
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Mendis, S. and Gill, S.
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stomach neoplasms ,hepatocellular cancer ,immunologic antineoplastic agents ,esophageal neoplasms ,microsatellite instability ,monoclonal antibodies ,colorectal neoplasms ,Gastrointestinal neoplasms - Abstract
Immunotherapy has been described as the &ldquo, fourth pillar&rdquo, of oncology treatment, in conjunction with surgery, chemotherapy, and radiotherapy. However, the role of immunotherapy in gastrointestinal tumours is still evolving. Data for checkpoint inhibition in esophagogastric, hepatocellular, colorectal, and anal squamous cell carcinomas are expanding. In phase iii trials in the second-line setting, PD-1 inhibitors have demonstrated positive results for the subset of esophageal cancers that are positive for PD-L1 at a combined positive score of 10 or more. Based on results of phase ii trials, PD-1 inhibitors were approved in North America for use in PD-L1&ndash, positive chemorefractory gastric cancers, in hepatocellular carcinoma after sorafenib exposure, and in treatment-refractory deficient mismatch repair (dmmr) or high microsatellite instability (msi-h) tumours, regardless of tissue site. Combination use of PD-1 and ctla-4 inhibitors has been approved by the U.S. Food and Drug Administration for chemorefractory dmmr or msi-h colorectal cancer. Responses to checkpoint inhibition are durable, particularly in the dmmr or msi-h colorectal cancer cohort. As trials of combination immunotherapy, immunotherapy in combination with other systemic therapies, and immunotherapy in combination with other treatment modalities move forward in multiple tumour sites, cautious optimism is called for. The treatment landscape is continually changing, and expanded indications are likely to be just around the corner.
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- 2020
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- View/download PDF
22. Quantifying circulating hypoxia-induced RNA transcripts in maternal blood to determine in utero fetal hypoxic status
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Whitehead, C, Teh, Tinn W, Walker, S P, Leung, C, Mendis, S, Lamour, L, and Tong, S
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- 2014
23. Magnetic resonance imaging of Ménière's disease: early clinical experience in a UK centre
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Pai, I, primary, Mendis, S, additional, Murdin, L, additional, Touska, P, additional, and Connor, S, additional
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- 2020
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24. Cautious Optimism—The Current Role of Immunotherapy in Gastrointestinal Cancers
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Mendis, S., primary and Gill, S., additional
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- 2020
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25. What are the cost-effective strategies for the primary prevention of stroke in low and middle income countries; a who perspective: MT30003
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Mendis, S
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- 2010
26. Prevention and care of stroke in low- and middle-income countries; the need for a public health perspective
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Mendis, S.
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- 2010
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27. World stroke day 2009
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Mendis, S.
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- 2009
- Full Text
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28. World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions
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Angelantonio, E. di, Kaptoge, S., Pennells, L., Bacquer, D. de, Cooney, M.T., Kavousi, M., Stevens, G., Riley, L., Savin, S., Altay, S., Amouyel, P., Assmann, G., Bell, S., Ben-Shlomo, Y., Berkman, L., Beulens, J.W., Bjorkelund, C., Blaha, M.J., Blazer, D.G., Bolton, T., Bonita, R., Brenner, B.H., Brunner, E.J., Casiglia, E., Chamnan, P., Choi, Y.H., Chowdhury, R., Coady, S., Crespo, C.J., Cushman, M., Dagenais, G.R., D'Agostino, R.B., Daimon, M., Davidson, K.W., Engstrom, G., Fang, X.H., Ford, I., Gallacher, J., Gansevoort, R.T., Gaziano, T.A., Giampaoli, S., Grandits, G., Grimsgaard, S., Grobbee, D.E., Gudnason, V., Guo, Q., Humphries, S., Iso, H., Jukema, J.W., Kauhanen, J., Kengne, A.P., Khalili, D., Khan, T., Knuiman, M., Koenig, W., Kromhout, D., Krumholz, H.M., Lam, T.H., Laughlin, G., Ibanez, A.M., Moons, K.G.M., Nietert, P.J., Ninomiya, T., Nordestgaard, B.G., O'Donnell, C., Palmieri, L., Patel, A., Perel, P., Price, J.F., Costa, R.B.D.E., Ridker, P.M., Rodriguez, B., Rosengren, A., Roussel, R., Sakurai, M., Salomaa, V., Sato, S., Schottker, B., Shara, N., Shaw, J.E., Shin, H.C., Simons, L.A., Sofianopoulou, E., Sundstrom, J., Tolonen, H., Ueshima, H., Volzke, H., Wallace, R.B., Wareham, N.J., Willeit, P., Wood, D., Wood, A., Zhao, D., Onuma, O., Woodward, M., Danaei, G., Roth, G., Mendis, S., Graham, I., Varghese, C., Ezzati, M., Jackson, R., Danesh, J., Nambi, V., Matsushita, K., Couper, D., Diabetes, A., Zimmet, P.Z., Barr, E.L.M., Atkins, R., Whincup, P.H., Study, B., Kiechl, S., Willeit, J., Rungger, G., Sofat, R., Dale, C., Casas, J.P., Tikhonoff, V., Hunt, K.J., Sutherland, S.E., Psaty, B.M., Tracy, R., Frikke-Schmidt, R., Jensen, G.B., Schnohr, P., Donfrancesco, C., Vanuzzo, D., Panico, S., Balkau, B., Bonnet, F., Fumeron, F., Simons, J., McLachlan, S., Guralnik, J., Khaw, K.T., Brenner, H., Zhang, Y., Holleczek, B., Cohort, F., Vartiainen, E., Jousilahti, P., Harald, K., Massaro, J.J., Pencina, M., Ramachandran, V., Susa, S., Oizumi, T., Kayama, T., Wilhelmsen, L., Lissner, L., Hange, D., Mehlig, K., Hata, J., Yoshida, D., Hirakawa, Y., Rutters, F., Elders, P.J.M., Kyowa, I., Kiyama, M., Yamagishi, K., Tuomainen, T.P., Virtanen, J., Salonen, J.T., Meade, T.W., Nilsson, P.M., Melander, O., Boer, I.H. de, DeFilippis, A.P., Kuller, L.H., Juan, S.I., Gillum, R.F., Kirkland, S., Shimbo, D., Schwartz, J.E., Imano, H., Harst, P. van der, Hillige, J.L., Bakker, S.J., Dallongeville, J., Ferrieres, J., Moitry, M., Stott, D.J., Despres, J.P., Laughlin, G.A., Daniels, L.B., McEvoy, L.K., Aspelund, T., Thorsson, B., Gudmundsson, E.F., Aribas, E., Rueda-Ochoa, O.L., Ikram, M.K., Heshmatollah, A., Ikram, M.A., Dorr, M., Nauck, M., Howard, B., Can, G., Ishizaki, M., Wilsgaard, T., Mathiesen, E., Giedraitis, V., Ingelsson, M., Cook, N., Buring, J., Schouw, Y.T. van der, Claessen, H., Rothenbacher, D., Arndt, V., Study, W.I., Shipley, M., Packard, C., Robertson, M., Young, R., Feskens, E., Geleijnse, J.M., Fang, X., Gu, D.F., Huxley, R., Imai, Y., Kim, H.C., Pan, W.H., Rodgers, A., Suh, I., Town, A., Okayama, A., Maegawa, H., Nakamura, M., Aoki, N., Wu, Z.S., Yao, C.H., Luszcz, M., Tang, Z., Liu, L.S., Xie, J.X., Norton, R., Ameratunga, S., MacMahon, S., Whitlock, G., Knuiman, M.W., Christensen, H., Wu, X.G., Zhou, J., Yu, X.H., Tamakoshi, W.A., Wu, Z.L., Chen, L.Q., Shan, G.L., Sritara, P., Duan, X.F., Li, Y.H., Jiang, C.Q., Woo, J., Ho, S.C., Hong, Z., Huang, M.S., Zhou, B., Fuh, J.L., Kita, Y., Choudhury, S.R., Jee, S.H., Kim, Woodward, M, Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Epidemiology, Epidemiology and Data Science, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, and APH - Health Behaviors & Chronic Diseases
- Subjects
Male ,10-YEAR RISK ,BLOOD-PRESSURE ,0302 clinical medicine ,Risk Factors ,Medicine and Health Sciences ,Medicine ,Uganda ,Cardiac and Cardiovascular Systems ,Prospective Studies ,030212 general & internal medicine ,Aged, 80 and over ,Medicine(all) ,Kardiologi ,lcsh:Public aspects of medicine ,PRIMARY-CARE ,Public Health, Global Health, Social Medicine and Epidemiology ,General Medicine ,Middle Aged ,3. Good health ,Pooled analysis ,Cardiovascular Diseases ,Egypt ,Female ,Adult ,PROSPECTIVE COHORTS ,030231 tropical medicine ,195 COUNTRIES ,Primary care ,World Health Organization ,Risk Assessment ,Article ,World health ,POOLED ANALYSIS ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Primary prevention ,Environmental health ,SYSTEMATIC ANALYSIS ,Humans ,Aged ,CHINESE POPULATION ,Chinese population ,business.industry ,Individual participant data ,lcsh:RA1-1270 ,R1 ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Disease risk ,business ,INDIVIDUAL PARTICIPANT DATA ,PRIMARY PREVENTION - Abstract
Background: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. Methods: In this model revision initiative, we derived 10-year risk prediction models for fatal and non-fatal cardiovascular disease (ie, myocardial infarction and stroke) using individual participant data from the Emerging Risk Factors Collaboration. Models included information on age, smoking status, systolic blood pressure, history of diabetes, and total cholesterol. For derivation, we included participants aged 40–80 years without a known baseline history of cardiovascular disease, who were followed up until the first myocardial infarction, fatal coronary heart disease, or stroke event. We recalibrated models using age-specific and sex-specific incidences and risk factor values available from 21 global regions. For external validation, we analysed individual participant data from studies distinct from those used in model derivation. We illustrated models by analysing data on a further 123 743 individuals from surveys in 79 countries collected with the WHO STEPwise Approach to Surveillance. Findings: Our risk model derivation involved 376 177 individuals from 85 cohorts, and 19 333 incident cardiovascular events recorded during 10 years of follow-up. The derived risk prediction models discriminated well in external validation cohorts (19 cohorts, 1 096 061 individuals, 25 950 cardiovascular disease events), with Harrell's C indices ranging from 0·685 (95% CI 0·629–0·741) to 0·833 (0·783–0·882). For a given risk factor profile, we found substantial variation across global regions in the estimated 10-year predicted risk. For example, estimated cardiovascular disease risk for a 60-year-old male smoker without diabetes and with systolic blood pressure of 140 mm Hg and total cholesterol of 5 mmol/L ranged from 11% in Andean Latin America to 30% in central Asia. When applied to data from 79 countries (mostly low-income and middle-income countries), the proportion of individuals aged 40–64 years estimated to be at greater than 20% risk ranged from less than 1% in Uganda to more than 16% in Egypt. Interpretation: We have derived, calibrated, and validated new WHO risk prediction models to estimate cardiovascular disease risk in 21 Global Burden of Disease regions. The widespread use of these models could enhance the accuracy, practicability, and sustainability of efforts to reduce the burden of cardiovascular disease worldwide. Funding: World Health Organization, British Heart Foundation (BHF), BHF Cambridge Centre for Research Excellence, UK Medical Research Council, and National Institute for Health Research. The WHO CVD Risk Chart Working Group, for complete list of authors see http://dx.doi.org/10.1016/S2214-109X(19)30318-3
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- 2019
- Full Text
- View/download PDF
29. Drivers of Germ Cell Maturation
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LOVELAND, K L, HOGARTH, C, MENDIS, S, EFTHYMIADIS, A, LY, J, ITMAN, C, MEACHEM, S, BROWN, C W, and JANS, D A
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- 2005
30. Third universal definition of myocardial infarction
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Thygesen, K, Alpert, Js, Jaffe, As, Simoons, Ml, Chaitman, Br, White, Hd, the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, Authors/Task Force Members Chairpersons, Biomarker, Subcommittee, Katus, Ha, Apple, Fs, Lindahl, B, Morrow, Da, Ecg, Subcommittee, Clemmensen, Pm, Johanson, P, Hod, H, Imaging, Subcommittee, Underwood, R, Bax, Jj, Bonow, Ro, Pinto, F, Gibbons, Rj, Classification, Subcommittee, Fox, Ka, Atar, D, Newby, Lk, Galvani, M, Hamm, Cw, Intervention, Subcommittee, Uretsky, Bf, Gabriel Steg, P, Wijns, W, Bassand, Jp, Menasché, P, Ravkilde, J, Trials, Registries, Subcommittee, Ohman, Em, Antman, Em, Wallentin, Lc, Armstrong, Pw, Heart Failure Subcommittee, Januzzi, Jl, Nieminen, Ms, Gheorghiade, M, Filippatos, G, Epidemiology, Subcommittee, Luepker, Rv, Fortmann, Sp, Rosamond, Wd, Levy, D, Wood, D, Global Perspective Subcommittee, Smith, Sc, Hu, D, Lopez Sendon JL, Robertson, Rm, Weaver, D, Tendera, M, Bove, Aa, Parkhomenko, An, Vasilieva, Ej, Mendis, S, ESC Committee for Practice Guidelines, Baumgartner, H, Ceconi, Claudio, Dean, V, Deaton, C, Fagard, R, Funck Brentano, C, Hasdai, D, Hoes, A, Kirchhof, P, Knuuti, J, Kolh, P, Mcdonagh, T, Moulin, C, Popescu, Ba, Reiner, Z, Sechtem, U, Sirnes, Pa, Torbicki, A, Vahanian, A, Windecker, S, Document, Reviewers, Morais, J, Aguiar, C, Almahmeed, W, Arnar, Do, Barili, F, Bloch, Kd, Bolger, Af, Bøtker, He, Bozkurt, B, Bugiardini, R, Cannon, C, de Lemos, J, Eberli, Fr, Escobar, E, Hlatky, M, James, S, Kern, Kb, Moliterno, Dj, Mueller, C, Neskovic, An, Pieske, Bm, Schulman, Sp, Storey, Rf, Taubert, Ka, Vranckx, P, Wagner, D. R., Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Lindahl B, Morrow DA, Clemmensen PM, Johanson P, Hod H, Underwood R, Bax JJ, Bonow JJ, Pinto F, Gibbons RJ, Fox KA, Atar D, Newby LK, Galvani M, Hamm CW, Uretsky BF, Steg PG, Wijns W, Bassand JP, Menasche P, Ravkilde J, Ohman EM, Antman EM, Wallentin LC, Armstrong PW, Januzzi JL, Nieminen MS, Gheorghiade M, Filippatos G, Luepker RV, Fortmann SP, Rosamond WD, Levy D, Wood D, Smith SC, Hu D, Lopez-Sendon JL, Robertson RM, Weaver D, Tendera M, Bove AA, Parkhomenko AN, Vasilieva EJ, Mendis S, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Torbicki A, Vahanian A, Windecker S, Morais J, Aguiar C, Almahmeed W, Arnar DO, Barili F, Bloch KD, Bolger AF, Botker HE, Bozkurt B, Bugiardini R, Cannon C, de Lemos J, Eberli FR, Escobar E, Hlatky M, James S, Kern KB, Moliterno DJ, Mueller C, Neskovic AN, Pieske BM, Schulman SP, Storey RF, Taubert KA, Vranckx P, Wagner DR., Cardiology, lLindahl B, K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoon, B. R. Chaitman, H. D. White, H. A. Katu, F. S. Apple, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbon, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. Gabriel Steg, W. Wijn, J.-P. Bassand, P. Menasche, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippato, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J.-L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendi, H. Baumgartner, C. Ceconi, V. Dean, C. Deaton, R. Fagard, C. Funck-Brentano, D. Hasdai, A. Hoe, P. Kirchhof, J. Knuuti, P. Kolh, T. McDonagh, C. Moulin, B. A. Popescu, Z. Reiner, U. Sechtem, P. A. Sirne, A. Torbicki, A. Vahanian, S. Windecker, J. Morai, C. Aguiar, W. Almahmeed, D. O. Arnar, F. Barili, K. D. Bloch, A. F. Bolger, H. E. Botker, B. Bozkurt, R. Bugiardini, C. Cannon, J. de Lemo, F. R. Eberli, E. Escobar, M. Hlatky, S. Jame, K. B. Kern, D. J. Moliterno, C. Mueller, A. N. Neskovic, B. M. Pieske, S. P. Schulman, R. F. Storey, K. A. Taubert, P. Vranckx, D. R. Wagner, Thygesen, K, Alpert, J, Jaffe, A, Simoons, Ml, Chaitman, Br, White, Hd, Katus, Ha, Apple, F, Lindahl, B, Morrow, Da, Clemmensen, Pm, Johanson, P, Hod, H, Underwood, R, Bax, Jj, Bonow, Jj, Pinto, F, Gibbons, Rj, Fox, Ka, Atar, D, Newby, Lk, Galvani, M, Hamm, Cw, Uretsky, Bf, Steg, Pg, Wijns, W, Bassand, Jp, Menasche, P, Ravkilde, J, Ohman, Em, Antman, Em, Wallentin, Lc, Armstrong, Pw, Januzzi, Jl, Nieminen, M, Gheorghiade, M, Filippatos, G, Luepker, Rv, Fortmann, Sp, Rosamond, Wd, Levy, D, Wood, D, Smith, Sc, Hu, D, Lopez-Sendon, Jl, Robertson, Rm, Weaver, D, Tendera, M, Bove, Aa, Parkhomenko, An, Vasilieva, Ej, Mendis, S, Baumgartner, H, Ceconi, C, Dean, V, Deaton, C, Fagard, R, Funck-Brentano, C, Hasdai, D, Hoes, A, Kirchhof, P, Knuuti, J, Kolh, P, Mcdonagh, T, Moulin, C, Popescu, Ba, Reiner, Z, Sechtem, U, Sirnes, Pa, Torbicki, A, Vahanian, A, Windecker, S, Morais, J, Aguiar, C, Almahmeed, W, Arnar, Do, Barili, F, Bloch, Kd, Bolger, Af, Botker, He, Bozkurt, B, Bugiardini, R, Cannon, C, de Lemos, J, Eberli, Fr, Escobar, E, Hlatky, M, James, S, Kern, Kb, Moliterno, Dj, Mueller, C, Neskovic, An, Pieske, Bm, Schulman, Sp, Storey, Rf, Taubert, Ka, Vranckx, P, and Wagner, Dr
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High-sensitivity troponin ,Ticagrelor ,Chest pain unit ,Quality Assurance, Health Care ,Epidemiology ,medicine.medical_treatment ,Myocardial Infarction ,Myocardial ischaemia ,Global Health ,Early invasive strategy ,Electrocardiography ,Stent ,Myocardial Revascularization ,Myocardial infarction ,Coronary Artery Bypass ,Intraoperative Complications ,Left bundle branch block ,Health Policy ,Electrocardiography in myocardial infarction ,Cangrelor ,Stents ,Acute coronary syndrome ,Cardiology and Cardiovascular Medicine ,Prasugrel ,Diagnostic Imaging ,medicine.medical_specialty ,Public Policy ,Risk Assessment ,Vorapaxar ,Percutaneous Coronary Intervention ,Physiology (medical) ,Terminology as Topic ,Humans ,Enoxaparin ,Bypass surgery ,Community and Home Care ,Heart Failure ,Rhythm monitoring ,Aspirin ,Unstable angina ,Angioplasty ,Recommendation ,ta3121 ,medicine.disease ,Myocardial infarction diagnosis ,Bivalirudin ,Biomarkers ,Time Factors ,Platelet inhibition ,Consensus Development Conferences as Topic ,Diagnostic Techniques, Cardiovascular ,Myocardial Ischemia ,Guideline ,Diabete ,Nitrate ,Left ventricular hypertrophy ,Coronary artery disease ,Rivaroxaban ,Recurrence ,Apixaban ,Clinical Trials as Topic ,Graft Occlusion, Vascular ,Atherothrombosi ,Acute cardiac care ,Right bundle branch block ,Clopidogrel ,Dabigatran ,Prosthesis Failure ,AHA Scientific Statements ,Practice Guidelines as Topic ,Cardiology ,Biological Markers ,Radiology ,Critical Care ,Glycoprotein IIb/IIIa inhibitor ,European Society of Cardiology ,Diagnosis, Differential ,Anticoagulation ,Internal medicine ,medicine ,Beta-blocker ,cardiovascular diseases ,Heparin ,business.industry ,Revascularization ,Cardiovascular Surgical Procedures ,MYOCARDIAL INFARCTION ,Statin ,Percutaneous coronary intervention ,Arrhythmias, Cardiac ,Cardiac Imaging Techniques ,Fondaparinux ,Heart failure ,Non-ST-elevation myocardial infarction ,business - Abstract
ACCF : American College of Cardiology Foundation ACS : acute coronary syndrome AHA : American Heart Association CAD : coronary artery disease CABG : coronary artery bypass grafting CKMB : creatine kinase MB isoform cTn : cardiac troponin CT : computed tomography CV : coefficient of variation ECG : electrocardiogram ESC : European Society of Cardiology FDG : fluorodeoxyglucose h : hour(s) HF : heart failure LBBB : left bundle branch block LV : left ventricle LVH : left ventricular hypertrophy MI : myocardial infarction mIBG : meta-iodo-benzylguanidine min : minute(s) MONICA : Multinational MONItoring of trends and determinants in CArdiovascular disease) MPS : myocardial perfusion scintigraphy MRI : magnetic resonance imaging mV : millivolt(s) ng/L : nanogram(s) per litre Non-Q MI : non-Q wave myocardial infarction NSTEMI : non-ST-elevation myocardial infarction PCI : percutaneous coronary intervention PET : positron emission tomography pg/mL : pictogram(s) per millilitre Q wave MI : Q wave myocardial infarction RBBB : right bundle branch block sec : second(s) SPECT : single photon emission computed tomography STEMI : ST elevation myocardial infarction ST–T : ST-segment –T wave URL : upper reference limit WHF : World Heart Federation WHO : World Health Organization Myocardial infarction (MI) can be recognised by clinical features, including electrocardiographic (ECG) findings, elevated values of biochemical markers (biomarkers) of myocardial necrosis, and by imaging, or may be defined by pathology. It is a major cause of death and disability worldwide. MI may be the first manifestation of coronary artery disease (CAD) or it may occur, repeatedly, in patients with established disease. Information on MI rates can provide useful information regarding the burden of CAD within and across populations, especially if standardized data are collected in a manner that …
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31. Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery
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Szarek, M, Bhatt, DL, Bittner, VA, Diaz, R, Edelberg, JM, Hanotin, C, Harrington, RA, Jukema, JW, Letierce, A, Moryusef, A, Pordy, R, Lopez, GAR, Roe, MT, White, HD, Zeiher, AM, Steg, PG, Schwartz, GG, Aylward, PE, Drexel, H, Sinnaeve, P, Dilic, M, Goodman, SG, Prieto, JC, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Ostadal, P, Poulsen, SH, Viigimaa, M, Nieminen, MS, Danchin, N, Chumburidze, V, Tse, HF, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, HS, Kim, SH, Erglis, A, Laucevicius, A, Kedev, S, Yusoff, K, Alings, M, Halvorsen, S, Flores, RMC, Sy, RG, Budaj, A, Morais, J, Dorobantu, M, Karpov, Y, Ristic, AD, Chua, T, Murin, J, Fras, Z, Tunon, J, de Silva, HA, Muller, C, Ray, KK, Vogel, R, Chaitman, B, Kelsey, SF, Olsson, AG, Rouleau, JL, Simoons, ML, Alexander, K, Meloni, C, Rosenson, R, Sijbrands, EJG, Alexander, JH, Armaganijan, L, Bagai, A, Bahit, MC, Brennan, JM, Clifton, S, DeVore, AD, Deloatch, S, Dickey, S, Dombrowski, K, Ducrocq, G, Eapen, Z, Endsley, P, Eppinger, A, Hess, CN, Hlatky, MA, Jordan, JD, Knowles, JW, Kolls, BJ, Kong, DF, Leonardi, S, Lillis, L, Maron, DJ, Marcus, J, Mathews, R, Mehta, RH, Mentz, RJ, Moreira, HG, Patel, CB, Pereira, SB, Perkins, L, Povsic, TJ, Puymirat, E, Jones, WS, Shah, BR, Sherwood, MW, Stringfellow, K, Sujjavanich, D, Toma, M, Trotter, C, van Diepen, SFP, Wilson, MD, Yan, ATK, Schiavi, LB, Garrido, M, Alvarisqueta, AF, Sassone, SA, Bordonava, AP, De Lima, AEA, Schmidberg, JM, Duronto, EA, Caruso, OC, Novaretto, LP, Hominal, MA, Montana, OR, Caccavo, A, Vilamajo, OAG, Lorenzatti, AJ, Cartasegna, LR, Paterlini, GA, Mackinnon, IJ, Caime, GD, Amuchastegui, M, Codutti, OR, Jure, HO, Bono, JOE, Hrabar, AD, Vallejos, JA, Rodolfo, AAG, Novoa, F, Patocchi, CA, Zaidman, CJ, Giuliano, ME, Dran, RD, Vico, ML, Carnero, GS, Guzman, PN, Allende, JCM, Brasca, DFG, Labarta, MHB, Nani, S, Blumberg, EDS, Colombo, HR, Liberman, A, Luciardi, HL, Waisman, GD, Berli, MA, Duran, ROG, Cestari, HG, Luquez, HA, Giordano, JA, 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Krichmar, P, White, L, Knickelbine, T, Haldis, T, Gillespie, E, Suh, D, Arif, I, Akhter, F, Carlson, E, D'Urso, M, El-Ahdab, F, Nelson, W, Harris, B, Cohen, S, Carter, L, Sabatino, K, Haddad, T, Malik, A, Rao, S, Mulkay, A, Jovin, I, Klancke, K, Malhotra, V, Devarapalli, SK, Koren, M, Chandna, H, Dodds, G, Janik, M, Moran, J, Sumner, A, Kobayashi, J, Davis, W, Yazdani, S, Pasquini, J, Thakkar, M, Vedere, A, Leimbach, W, Rider, J, Singh, N, Shah, AV, Moriarty, PM, Janosik, D, Pepine, C, Berman, B, Gelormini, J, Daniels, C, Keating, F, Kondo, NI, Shetty, S, Waider, W, Takata, T, Abu-Fadel, M, Shah, V, Aggarwal, R, Izzo, M, Kumar, A, Hattler, B, Link, C, Bortnick, A, Kinzfogl, G, Ghitis, A, Larry, J, Teufel, E, Kuhlman, P, Mclaurin, B, Zhang, WW, Thew, S, Abbas, J, White, M, Ranadive, N, Gring, C, Henderson, D, Schuchard, T, Farhat, N, Kline, G, Mahal, S, Whitaker, J, Speirs, S, Andersen, R, Daboul, N, Horwitz, P, Jafar, Z, Mcgarvey, J, Panchal, V, Voyce, S, Blok, T, Sheldon, W, Azizad, MM, Schmalfuss, C, Picone, M, Herzog, W, Lindsey, J, Nowins, R, Lepor, N, El Shahawy, M, Weintraub, H, Irimpen, A, May, W, Galski, T, Chu, A, Mody, F, Hodes, Z, Fairlamb, J, Lambert, C, Raisinghani, A, Abbate, A, King, M, Carey, C, Gerber, J, Younis, L, Park, H, Vidovich, M, Knutson, T, Friedman, D, Chaleff, F, Loussararian, A, Kimmelstiel, C, Silver, K, Foster, M, Tonnessen, G, Amlani, M, Wali, A, Malozzi, C, Wattanakit, K, O'Donnell, PJ, Singal, D, Jaffrani, N, Banuru, S, Fisher, D, Xenakis, M, Perlmutter, N, Bhagwat, R, Strader, J, Akyea-Djamson, A, Labroo, A, Marais, HJ, Claxton, E, Berk, M, Rossi, P, Joshi, P, Khaira, AS, Kumkumian, G, Lupovitch, S, Purow, J, Welka, S, Hoffman, D, Fischer, S, Soroka, E, Eagerton, D, Pancholy, S, Ray, M, Farrar, M, Pollock, S, French, WJ, Diamantis, S, Gimple, L, Schwartz, S, Pereira, E, Spriggs, D, Strain, J, Vo, A, Chane, M, Hall, J, Vijay, N, Lotun, K, Lester, FM, Nahhas, A, Pope, T, Nager, P, Vohra, R, Bashir, R, Ahmed, H, Berlowitz, M, Fishberg, R, Barrucco, R, Yang, E, Radin, M, Sporn, D, Eisenberg, S, Landzberg, J, Mcgough, M, Turk, S, Schwartz, M, Sundram, PS, Jain, D, Zainea, M, Bayron, C, Karlsberg, R, Lui, H, Keen, W, Westerhausen, D, Khurana, S, Agarwal, H, Birchem, J, Penny, W, Chang, M, Gilbert, JM, Chalavarya, G, Eaton, C, Schmedtje, JF, Christenson, S, Denham, D, Macdonell, A, Gibson, P, Rahman, A, Al Joundi, T, Conrad, G, Kotha, P, Love, M, Giesler, G, Rubenstein, H, Akright, L, Schifferdecker, B, Krawczyk, J, Wells, T, Welker, J, Foster, R, Gilmore, R, Anderson, J, Jacoby, D, Gardner, G, Dandillaya, R, Vora, K, Kostis, J, Hunter, J, Laxson, D, Ball, E, İÜC, and Ege Üniversitesi
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Male ,medicine.medical_specialty ,Acute coronary syndrome ,alirocumab ,030204 cardiovascular system & hematology ,Antibodies, Monoclonal, Humanized ,lipids ,PCSK9 ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Double-Blind Method ,coronary artery bypass graft ,Internal medicine ,medicine ,Humans ,Cardiac and Cardiovascular Systems ,030212 general & internal medicine ,Myocardial infarction ,cardiovascular diseases ,Acute Coronary Syndrome ,Coronary Artery Bypass ,Alirocumab ,Aged ,Kardiologi ,business.industry ,Unstable angina ,Hazard ratio ,cholesterol ,Middle Aged ,medicine.disease ,surgical procedures, operative ,Bypass surgery ,Cardiovascular Diseases ,Cardiology ,Drug Therapy, Combination ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business ,Mace - Abstract
Sherwood, Matthew/0000-0002-4305-5883; Taskinen, Marja-Riitta/0000-0002-6229-3588; Leonardi, Sergio/0000-0002-4800-6132; Raffel, Owen C/0000-0001-5470-7050; Muenzel, Thomas/0000-0001-5503-4150; Ersanli, Murat/0000-0003-1847-3087; Gislason, Gunnar H/0000-0002-0548-402X; bastos, jose/0000-0002-9526-3123; Abbate, Antonio/0000-0002-1930-785X; Chumakova, Galina A/0000-0002-2810-6531; Nikolaev, Konstantin/0000-0003-4601-6203; Tse, Hung Fat/0000-0002-9578-7808; Keskin, Kudret/0000-0002-9049-1530; Reshetko, Olga/0000-0003-3107-7636; Podoleanu, Cristian/0000-0001-9987-2519; Aylward, Philip/0000-0002-5358-8552; LETIERCE, Alexia/0000-0001-6679-5772, WOS: 000483334800002, PubMed: 31466614, BACKGROUND Patients with acute coronary syndrome (ACS) and history of coronary artery bypass grafting (CABG) are at high risk for recurrent cardiovascular events and death. OBJECTIVES This study sought to determine the clinical benefit of adding alirocumab to statins in ACS patients with prior CABG in a pre-specified analysis of ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab). METHODS Patients (n = 18,924) 1 to 12 months post-ACS with elevated atherogenic lipoprotein levels despite high-intensity statin therapy were randomized to alirocumab or placebo subcutaneously every 2 weeks. Median follow-up was 2.8 years. the primary composite endpoint of major adverse cardiovascular events (MACE) comprised coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or unstable angina requiring hospitalization. All-cause death was a secondary endpoint. Patients were categorized by CABG status: no CABG (n = 16,896); index CABG after qualifying ACS, but before randomization (n = 1,025); or CABG before the qualifying ACS (n = 1,003). RESULTS in each CABG category, hazard ratios (95% confidence intervals) for MACE (no CABG 0.86 [0.78 to 0.95], index CABG 0.85 [0.54 to 1.35], prior CABG 0.77 [0.61 to 0.98]) and death (0.88 [ 0.75 to 1.03], 0.85 [0.46 to 1.59], 0.67 [0.44 to 1.01], respectively) were consistent with the overall trial results (0.85 [ 0.78 to 0.93] and 0.85 [0.73 to 0.98], respectively). Absolute risk reductions (95% confidence intervals) differed across CABG categories for MACE (no CABG 1.3% [0.5% to 2.2%], index CABG 0.9% [-2.3% to 4.0%], prior CABG 6.4% [0.9% to 12.0%]) and for death (0.4% [-0.1% to 1.0%], 0.5% [-1.9% to 2.9%], and 3.6% [0.0% to 7.2%]). CONCLUSIONS Among patients with recent ACS and elevated atherogenic lipoproteins despite intensive statin therapy, alirocumab was associated with large absolute reductions in MACE and death in those with CABG preceding the ACS event. (ODYSSEY OUTCOMES: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402) (C) 2019 by the American College of Cardiology Foundation., Fondation Assistance Publique-Hopitaux de Paris, Paris, France, The authors thank the patients, study coordinators, and investigators who participated in this trial. Sophie Rushton-Smith, PhD (MedLink Healthcare Communications, London) provided editorial assistance in the preparation of the manuscript (limited to editing for style, referencing, and figure and table editing) and was funded by Fondation Assistance Publique-Hopitaux de Paris, Paris, France.
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- 2019
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32. Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial
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K, Coste, P, Ferrari, E, Morel, O, Montalescot, G, Barone-Rochette, G, Mansourati, J, Cottin, Y, Leclercq, F, Belhassane, A, Delarche, N, Boccara, F, Paganelli, F, Clerc, J, Schiele, F, Aboyans, V, Probst, V, Berland, J, Lefevre, T, Citron, B, Khintibidze, I, Shaburishvili, T, Pagava, Z, Ghlonti, R, Lominadze, Z, Khabeishvili, G, Hemetsberger, R, Rauch-Kroehnert, U, Stratmann, M, Appel, K-F, Schmidt, E, Omran, H, Stellbrink, C, Dorsel, T, Lianopoulos, E, Marx, R, Zirlik, A, Schellenberg, D, Heitzer, T, Laufs, U, Gielen, S, Winkelmann, B, Behrens, S, Sydow, K, Simonis, G, Muenzel, T, Werner, N, Leggewie, S, Boecker, D, Braun-Dullaeus, R, Toursarkissian, N, Jeserich, M, Weissbrodt, M, Schaeufele, T, Weil, J, Voeller, H, Waltenberger, J, Natour, M, Schmitt, S, Steiner, S, Heidenreich, L, Gremmler, U, Killat, H, Rieker, W, Patsilinakos, S, Kartalis, A, Manolis, A, Sionis, D, Skoumas, I, Athyros, V, Vardas, P, Parthenakis, F, Alexopoulos, D, Hahalis, G, Lekakis, J, Hatzitolios, A, Ovando, 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BJWM, Bokern, MJJA, Nijmeijer, R, Hersbach, FMRJ, Willems, FF, Gosselink, ATM, Elliott, J, Wilkins, G, Fisher, R, Scott, D, Hart, H, Stewart, R, Harding, S, Ternouth, I, Fisher, N, Aitken, D, Anscombe, R, Davidson, L, Tomala, T, Nygard, O, Sparby, JA, Andersen, K, Gullestad, L, Jortveit, J, Munk, PS, Singsaas, EG, Hurtig, U, Calderon Ticona, JR, Durand Velasquez, JR, Negron Miguel, SA, Sanabria Perez, ES, Carrion Chambilla, JM, Chavez Ayala, CA, Castillo Leon, RP, Vargas Gonzales, RJ, Hernandez Zuniga, JD, Camacho Cosavalente, LA, Bravo Mannucci, JE, Heredia Landeo, J, Llerena Navarro, NC, Roldan Concha, YM, Rodriguez Chavez, V-CE, Anchante Hernandez, HA, Zea Nunez, CA, Mogrovejo Ramos, W, Ferrolino, A, Sy, RAG, Tirador, L, Matiga, G, Coching, RM, Bernan, A, Rogelio, G, Morales, DD, Tan, E, Sulit, DJ, Wlodarczak, A, Jaworska, K, Skonieczny, G, Pawlowicz, L, Wojewod, P, Busz-Papiez, B, Bednarski, J, Goch, A, Staneta, P, Dulak, E, Saminsk, K, Krasowski, W, Sudnik, W, Zurakowski, A, Skorski, M, Lysek, R, Miklaszewicz, B, Kubica, J, Lipko, JA, Kostarska-Srokosz, E, Piepiorka, M, Drzewiecka, A, Sciborski, R, Stasiewski, A, Blicharski, T, Bystryk, L, Szpajer, M, Korol, M, Czerski, T, Mirek-Bryniarska, E, Gniot, J, Lubinski, A, Gorny, J, Franek, E, Raczak, G, Szwed, H, Monteiro, P, Bastos, JM, Pereira, HH, Martins, D, Seixo, F, Mendonca, C, Botelho, A, Minescu, B, Istratoaie, O, Tesloianu, DN, Cristian, G, Podoleanu, CGC, Constantinescu, MCA, Bengus, CM, Militaru, C, Rosu, D, Parepa, IR, Matei, AV, Alexandru, TM, Coman, I, Cioranu, RS, Dimulescu, D, Shvarts, Y, Orlikova, O, Kobalava, Z, Barbarash, OL, Markov, V, Lyamina, N, Gordienko, A, Zrazhevsky, K, Vishnevsky, AY, Gurevich, V, Stryuk, R, Lomakin, NV, Bokarev, I, Shalaev, S, Khaisheva, L, Chizhov, P, Viktorova, I, Osokina, N, Akatova, E, Chumakova, G, Libov, I, Voevoda, MI, Tretyakova, TV, Baranov, E, Shustov, S, Yakushin, S, Gordeev, I, Khasanov, N, Reshetko, O, Sotnikova, T, Molchanova, O, Nikolaev, K, Gapon, L, 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Gonzalez-Juanatey, JR, Fernandez Portales, J, Civeira Murillo, F, Matas Pericas, L, Luis Zamorano, J, De Mora Martin, M, Bruguera Cortada, J, Alonso Martin, JJ, De Berrazueta Fernandez, JR, Diaz Fernandez, JF, Garcia Lledo, JA, Cosin Sales, J, Botas Rodriguez, J, Gusi Tragant, G, Benedicto, A, Gonzalez-Juanatey, C, Camprubi Potau, M, Plaza Perez, I, Moris De La Tassa, C, Loma-Osorio Rincon, P, Balaguer Recena, J, Escudier, JM, Coca Payeras, A, Alonso Orcajo, N, Valdivielso, P, Constantine, G, Haniffa, R, Tissera, N, Amarasekera, S, Fernando, N, Jayawardena, J, Santharaj, W, Ekanayaka, R, Mendis, S, Senaratne, V, Mayurathan, G, Sirisena, T, Rajapaksha, A, Herath, JI, Amarasena, N, Berglund, S, Rasmanis, G, Witt, N, Mourtzinis, G, Nicol, P, Hansen, O, Romeo, S, Jensen, SA, Torstensson, I, Ahremark, U, Sundelin, T, Moccetti, T, Mach, F, Binder, R, Tsai, W-C, Ueng, K-C, Lai, W-T, Liu, M-E, Hwang, J-J, Yin, W-H, Hsieh, I-C, Lin, WH, Kuo, J-Y, Huang, T-Y, Fang, C-Y, Kaewsuwanna, P, Soonfuang, W, Jintapakorn, W, Sukonthasarn, A, Wongpraparut, N, Sastravaha, K, Sansanayudh, N, Kehasukcharoen, W, Piyayotai, D, Chotnoparatpat, P, Camsari, A, Kultursay, H, Mutlu, B, Ersanli, M, Demirtas, M, Kirma, C, Ural, E, Koldas, L, Karpenko, O, Prokhorov, A, Vakaluyk, I, Myshanych, H, Reshotko, D, Batushkin, V, Rudenko, L, Kovalskyi, I, Kushnir, M, Tseluyko, V, Mostovoy, Y, Stanislavchuk, M, Kyiak, Y, Karpenko, Y, Malynovsky, Y, Klantsa, A, Kutniy, O, Amosova, E, Tashchuk, V, Leshchuk, O, Rishko, M, Kopytsya, M, Yagensky, A, Vatutin, M, Bagriy, A, Barna, OM, Ushakov, O, Dzyak, G, Goloborodko, B, Rudenko, A, Zheleznyy, V, Trevelyan, J, Zaman, A, Lee, K, Moriarty, A, Aggarwal, RK, Clifford, P, Wong, Y-K, Iqbal, SMR, Subkovas, E, Braganza, D, Sarkar, D, Storey, R, Griffiths, H, Mcclure, S, Muthusamy, R, Kurian, J, Levy, T, Barr, C, Kadr, H, Gerber, R, Simaitis, A, Soran, H, Mathur, A, Brodison, A, Oliver, R, Mudawi, T, Reynolds, T, Sharman, D, Butler, R, Wilkinson, P, Lip, GYH, Halcox, J, Vardi, G, Baldari, D, Brabham, D, Treasure, C, Dahl, C, Palmer, B, Wiseman, A, Puri, S, Mohart, AE, Ince, C, Flores, E, Wright, S, Cheng, S-C, Rosenberg, M, Rogers, W, Kosinski, E, Forgosh, L, Waltman, J, Khan, M, Shoukfeh, M, Dagher, G, Lieber, I, Kumar, P, East, C, Krichmar, P, White, L, Knickelbine, T, Haldis, T, Gillespie, E, Suh, D, Arif, I, Akhter, F, Carlson, E, D'Urso, M, El-Ahdab, F, Nelson, W, Harris, B, Cohen, S, Carter, L, Sabatino, K, Haddad, T, Malik, A, Rao, S, Mulkay, A, Jovin, I, Klancke, K, Malhotra, V, Devarapalli, SK, Koren, M, Chandna, H, Dodds, G, Janik, M, Moran, J, Sumner, A, Kobayashi, J, Davis, W, Yazdani, S, Pasquini, J, Thakkar, M, Vedere, A, Leimbach, W, Rider, J, Singh, N, Shah, AV, Janosik, D, Pepine, C, Berman, B, Gelormini, J, Daniels, C, Keating, F, Kondo, NI, Shetty, S, Waider, W, Takata, T, Abu-Fadel, M, Shah, V, Aggarwal, R, Izzo, M, Kumar, A, Hattler, B, Link, C, Bortnick, A, Kinzfogl, G, Ghitis, A, Larry, J, Teufel, E, Kuhlman, P, Mclaurin, B, Zhang, W, Thew, S, Abbas, J, White, M, Ranadive, N, Gring, C, Henderson, D, Schuchard, T, Farhat, N, Kline, G, Mahal, S, Whitaker, J, Speirs, S, Andersen, R, Daboul, N, Horwitz, P, Ponce, G, Jafar, Z, Mcgarvey, J, Panchal, V, Voyce, S, Blok, T, Sheldon, W, Azizad, MM, Schmalfuss, C, Picone, M, Herzog, W, Lindsey, J, Nowins, R, Lepor, N, El Shahawy, M, Weintraub, H, Irimpen, A, May, W, Galski, T, Chu, A, Mody, F, Hodes, Z, Rose, G, Fairlamb, J, Lambert, C, Raisinghani, A, Abbate, A, King, M, Carey, C, Gerber, J, Younis, L, Park, HT, Vidovich, M, Knutson, T, Friedman, D, Chaleff, F, Loussararian, A, Rozeman, P, Kimmelstiel, C, Silver, K, Foster, M, Tonnessen, G, Amlani, M, Wali, A, Malozzi, C, Wattanakit, K, O'Donnell, PJ, Singal, D, Jaffrani, N, Banuru, S, Fisher, D, Xenakis, M, Perlmutter, N, Bhagwat, R, Strader, J, Akyea-Djamson, A, Labroo, A, Marais, HJ, Claxton, E, Berk, M, Rossi, P, Joshi, P, Khaira, AS, Kumkumian, G, Lupovitch, S, Purow, J, Welka, S, Hoffman, D, Fischer, S, Soroka, E, Eagerton, D, Pancholy, S, Ray, M, Farrar, M, Pollock, S, French, WJ, Diamantis, S, Gimple, L, Neustel, M, Schwartz, S, Pereira, E, Spriggs, D, Strain, J, Vo, A, Chane, M, Hall, J, Vijay, N, Lotun, K, Lester, FM, Nahhas, A, Pope, T, Nager, P, Vohra, R, Bashir, R, Ahmed, H, Berlowitz, M, Fishberg, R, Barrucco, R, Yang, E, Radin, M, Sporn, D, Eisenberg, S, Landzberg, J, Mcgough, M, Turk, S, Schwartz, M, Sundram, PS, Jain, D, Zainea, M, Bayron, C, Karlsberg, R, Lui, H, Keen, W, Westerhausen, D, Khurana, S, Agarwal, H, Birchem, J, Penny, W, Chang, M, Murphy, S, Schifferdecker, B, Gilbert, JM, Chalavarya, G, Eaton, C, Schmedtje, JF, Christenson, S, Denham, D, Macdonell, A, Gibson, P, Rahman, A, Al Joundi, T, Conrad, G, Kotha, P, Love, M, Giesler, G, Rubenstein, H, Akright, L, Krawczyk, J, Wells, T, Welker, J, Foster, R, Gilmore, R, Anderson, J, Jacoby, D, Gardner, G, Dandillaya, R, Vora, K, Kostis, J, Hunter, J, Laxson, D, Ball, E, Camp, A, Lopes, R, Egydio, F, Kawakami, A, Oliveira, J, Wozniak, J, Matthews, A, Ratky, C, Valiris, J, Berdan, L, Hepditch, A, Quintero, K, Rorick, T, Westbrook, M, Pascual, A, Rovito, C, Bezault, M, Drouet, E, Simon, T, Alsweiler, C, Luyten, A, Aylward, P, Butters, J, Griffith, L, Shaw, M, Grunberg, L, Islam, S, Bougon, N, Faustino, D, Fontecave, S, Murphy, J, Verrier, M, Agnetti, V, Andersen, D, Badreddine, E, Bekkouche, M, Bouancheau, C, Brigui, I, Brocklehurst, M, Cianciarulo, J, Devaul, D, Domokos, S, Gache, C, Gobillot, C, Guillou, S, Healy, J, Heath, M, Jaiwal, G, Javierre, C, Labeirie, J, Monier, M, Morales, U, Mrabti, A, Mthombeni, B, Okan, B, Smith, L, Sheller, J, Sopena, S, Pellan, V, Benbernou, F, Bengrait, N, Lamoureux, M, Kralova, K, Scemama, M, Bejuit, R, Coulange, A, Berthou, C, Repincay, J, Lorenzato, C, Etienne, A, Gouet, V, Loizeau, V, Normand, M, Ourliac, A, Rondel, C, Adamo, A, Beltran, P, Barraud, P, Dubois-Gache, H, Halle, B, Metwally, L, Mourgues, M, Sotty, M, Vincendet, M, Cotruta, R, Zhu, C, Fournie-Lloret, D, Morrello, C, Perthuis, A, Picault, P, Zobouyan, I, ODYSSEY OUTCOMES Comm, İÜC, Ege Üniversitesi, Rushton-Smith, Sophie, and ODYSSEY OUTCOMES Committees and Investigators
- Subjects
Male ,Cardiac & Cardiovascular Systems ,MONOCLONAL-ANTIBODY ,alirocumab ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ,law.invention ,PCSK9 ,chemistry.chemical_compound ,Randomized controlled trial ,law ,Cardiac and Cardiovascular Systems ,1102 Cardiorespiratory Medicine and Haematology ,Hypercholesterolemia/blood ,Kardiologi ,Hazard ratio ,Middle Aged ,Treatment Outcome ,SAFETY ,Cardiology ,Female ,Drug Therapy, Combination ,Cholesterol, LDL/antagonists & inhibitors ,Cardiology and Cardiovascular Medicine ,Life Sciences & Biomedicine ,REDUCING LIPIDS ,Akutes Koronarsyndrom ,acute coronary syndrome ,cholesterol ,mortality ,PCSK9 protein ,Antibodies, Monoclonal, Humanized/administration & dosage ,medicine.medical_specialty ,Acute coronary syndrome ,Injections, Subcutaneous ,Hypercholesterolemia ,Placebo ,Antibodies, Monoclonal, Humanized ,1117 Public Health and Health Services ,Sterblichkeit ,Double-Blind Method ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,ddc:610 ,Alirocumab ,Aged ,Science & Technology ,Cholesterol ,business.industry ,EVOLOCUMAB ,1103 Clinical Sciences ,Cholesterol, LDL ,medicine.disease ,EFFICACY ,Increased risk ,chemistry ,Peripheral Vascular Disease ,Cardiovascular System & Hematology ,Cardiovascular System & Cardiology ,Acute Coronary Syndrome/blood ,Cholesterin ,Human medicine ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,Follow-Up Studies - Abstract
bastos, jose/0000-0002-9526-3123; Manakshe, Gajendra/0000-0002-4983-4271; Tse, Hung Fat/0000-0002-9578-7808; Gislason, Gunnar H/0000-0002-0548-402X; Taskinen, Marja-Riitta/0000-0002-6229-3588; Racca, Vittorio/0000-0002-4465-3789; Keskin, Kudret/0000-0002-9049-1530; Sherwood, Matthew/0000-0002-4305-5883; Sandhu, Manjinder/0000-0003-2538-2079; Nikolaev, Konstantin/0000-0003-4601-6203; Ersanli, Murat/0000-0003-1847-3087; Raffel, Owen C/0000-0001-5470-7050; Abbate, Antonio/0000-0002-1930-785X; Muenzel, Thomas/0000-0001-5503-4150; Leonardi, Sergio/0000-0002-4800-6132; Chumakova, Galina A/0000-0002-2810-6531; Podoleanu, Cristian/0000-0001-9987-2519; Pereira, Helder/0000-0001-8656-4883; Reshetko, Olga/0000-0003-3107-7636, WOS: 000476768100007, PubMed: 31117810, Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. in a prespecified analysis of 8242 patients eligible for >= 3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P= 100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; P-interaction=0.007). in the alirocumab group, all-cause death declined with achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for >= 3 years, if baseline LDL-C is >= 100 mg/dL, or if achieved LDL-C is low., Sanofi; Regeneron Pharmaceuticals, Inc., The trial was funded by Sanofi and Regeneron Pharmaceuticals, Inc.
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- 2019
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33. Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial
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Dimkovic, S, Poh, KK, Ong, HY, Micko, K, Nociar, J, Pella, D, Fulop, P, Hranai, M, Palka, J, Mazur, J, Majercak, I, Dzupina, A, Fazekas, F, Gonsorcik, J, Bugan, V, Selecky, J, Kamensky, G, Strbova, J, Smik, R, Dukat, A, Olexa, P, Zuran, I, Poklukar, J, Suligoj, NC, Cevc, M, Cyster, HP, Ranjith, N, Corbett, C, Bayat, J, Makotoko, EM, Kapp, IE, Basson, MMD, Lottering, H, Van Zyl, LJ, Sebastian, PJ, Pillay, T, Saaiman, JA, Commerford, PJ, Cassimjee, S, Ebrahim, IO, Sarvan, M, Mynhardt, JH, Reuter, H, Moodley, R, Vida, M, Fillat, ARC, Peris, VB, Jimenez, FF, Marin, F, Fernandez, JMC, Gil-Extremera, B, Diz, FW, Garcia-Dorado, D, Iniguez, A, Fernandez, JT, Gonzalez-Juanatey, JR, Portales, JF, Murillo, FC, Pericas, LM, Zamorano, JL, Martin, MD, Cortada, JB, Martin, JJA, Fernandez, JRD, Fernandez, JFD, Lledo, JAG, Sales, JC, Rodriguez, JB, Tragant, GG, Benedicto, A, Gonzalez-Juanatey, C, Potau, MC, Perez, IP, De La Tassa, CM, Rincon, PLO, Recena, JB, Escudier, JM, Payeras, AC, Orcajo, NA, Valdivielso, P, Constantine, G, Haniffa, R, Tissera, N, Amarasekera, S, Fernando, N, Jayawardena, J, Santharaj, W, Ekanayaka, R, Mendis, S, Senaratne, V, Mayurathan, G, Sirisena, T, Rajapaksha, A, Herath, JI, Amarasena, N, Berglund, S, Rasmanis, G, Witt, N, Mourtzinis, G, Nicol, P, Hansen, O, Romeo, S, Jensen, SA, Torstensson, I, Ahremark, U, Sundelin, T, Moccetti, T, Muller, C, Mach, F, Binder, R, Tsai, WC, Ueng, KC, Lai, WT, Liu, ME, Hwang, JJ, Yin, WH, Hsieh, IC, Kuo, JY, Huang, TY, Fang, CY, Kaewsuwanna, P, Soonfuang, W, Jintapakorn, W, Sukonthasarn, A, Wongpraparut, N, Sastravaha, K, Sansanayudh, N, Kehasukcharoen, W, Piyayotai, D, Chotnoparatpat, P, Camsari, A, Kultursay, H, Mutlu, B, Ersanli, M, Demirtas, M, Kirma, C, Ural, E, Koldas, L, Karpenko, O, Prokhorov, A, Vakaluyk, I, Myshanych, H, Reshotko, D, Batushkin, V, Rudenko, L, Kovalskyi, I, Kushnir, M, Tseluyko, V, Mostovoy, Y, Stanislavchuk, M, Kyiak, Y, Karpenko, Y, Malynovsky, Y, Klantsa, A, Kutniy, O, Amosova, E, Tashchuk, V, Leshchuk, O, Rishko, M, Kopytsya, M, Yagensky, A, Vatutin, M, Bagriy, A, Barna, OM, Ushakov, O, Dzyak, G, Goloborodko, B, Rudenko, A, Zheleznyy, V, Trevelyan, J, Zaman, A, Lee, K, Moriarty, A, Aggarwal, RK, Clifford, P, Wong, YK, Iqbal, SM, Subkovas, E, Braganza, D, Sarkar, D, Storey, R, Griffiths, H, Mcclure, S, Muthusamy, R, Kurian, J, Levy, T, Barr, C, Kadr, H, Gerber, R, Simaitis, A, Soran, H, Mathur, A, Brodison, A, Oliver, R, Mudawi, T, Reynolds, T, Sharman, D, Butler, R, Wilkinson, P, Lip, GYH, Halcox, J, Vardi, G, Baldari, D, Brabham, D, Treasure, C, Dahl, C, Palmer, B, Wiseman, A, Puri, S, Mohart, AE, Ince, C, Flores, E, Wright, S, Cheng, SC, Rosenberg, M, Rogers, W, Kosinski, E, Forgosh, L, Waltman, J, Khan, M, Shoukfeh, M, Dagher, G, Lieber, I, Kumar, P, East, C, Krichmar, P, White, L, Knickelbine, T, Haldis, T, Gillespie, E, Suh, D, Arif, I, Akhter, F, Carlson, E, D'Urso, M, El-Ahdab, F, Nelson, W, Harris, B, Cohen, S, Carter, L, Sabatino, K, Haddad, T, Malik, A, Rao, S, Mulkay, A, Jovin, I, Klancke, K, Malhotra, V, Devarapalli, SK, Koren, M, Chandna, H, Dodds, G, Janik, M, Moran, J, Sumner, A, Kobayashi, J, Davis, W, Yazdani, S, Pasquini, J, Thakkar, M, Vedere, A, Leimbach, W, Rider, J, Singh, N, Shah, AV, Janosik, D, Pepine, C, Berman, B, Gelormini, J, Daniels, C, Keating, F, Kondo, NI, Shetty, S, Waider, W, Takata, T, Abu-Fadel, M, Shah, V, Aggarwal, R, Izzo, M, Kumar, A, Hattler, B, Link, C, Bortnick, A, Kinzfogl, G, Ghitis, A, Larry, J, Teufel, E, Kuhlman, P, Mclaurin, B, Zhang, WW, Thew, S, Abbas, J, White, M, Ranadive, N, Gring, C, Henderson, D, Schuchard, T, Farhat, N, Kline, G, Mahal, S, Whitaker, J, Speirs, S, Andersen, R, Daboul, N, Horwitz, P, Ponce, G, Jafar, Z, Mcgarvey, J, Panchal, V, Voyce, S, Blok, T, Sheldon, W, Azizad, MM, Schmalfuss, C, Picone, M, Herzog, W, Lindsey, J, Nowins, R, Lepor, N, El Shahawy, M, Weintraub, H, Irimpen, A, May, W, Galski, T, Chu, A, Mody, F, Hodes, Z, Rose, G, Fairlamb, J, Lambert, C, Raisinghani, A, Abbate, A, King, M, Carey, C, Gerber, J, Younis, L, Park, H, Vidovich, M, Knutson, T, Friedman, D, Chaleff, F, Loussararian, A, Rozeman, P, Kimmelstiel, C, Silver, K, Foster, M, Tonnessen, G, Amlani, M, Wali, A, Malozzi, C, Wattanakit, K, O'Donnell, PJ, Singal, D, Jaffrani, N, Banuru, S, Fisher, D, Xenakis, M, Perlmutter, N, Bhagwat, R, Strader, J, Akyea-Djamson, A, Labroo, A, Marais, HJ, Claxton, E, Berk, M, Rossi, P, Joshi, P, Khaira, AS, Kumkumian, G, Lupovitch, S, Purow, J, Welka, S, Hoffman, D, Fischer, S, Soroka, E, Eagerton, D, Pancholy, S, Ray, M, Farrar, M, Pollock, S, French, WJ, Diamantis, S, Gimple, L, Neustel, M, Schwartz, S, Pereira, E, Spriggs, D, Strain, J, Vo, A, Chane, M, Hall, J, Vijay, N, Lotun, K, Lester, FM, Nahhas, A, Pope, T, Nager, P, Vohra, R, Bashir, R, Ahmed, H, Berlowitz, M, Fishberg, R, Barrucco, R, Yang, E, Radin, M, Sporn, D, Eisenberg, S, Landzberg, J, Mcgough, M, Turk, S, Schwartz, M, Sundram, PS, Jain, D, Zainea, M, Bayron, C, Karlsberg, R, Lui, H, Keen, W, Westerhausen, D, Khurana, S, Agarwal, H, Birchem, J, Penny, W, Chang, M, Murphy, S, Schifferdecker, B, Gilbert, JM, Chalavarya, G, Eaton, C, Schmedtje, JF, Christenson, S, Denham, D, Macdonell, A, Gibson, P, Rahman, A, Al Joundi, T, Conrad, G, Kotha, P, Love, M, Giesler, G, Rubenstein, H, Akright, L, Krawczyk, J, Wells, T, Welker, J, Foster, R, Gilmore, R, Anderson, J, Jacoby, D, Gardner, G, Dandillaya, R, Vora, K, Kostis, J, Hunter, J, Laxson, D, Ball, E, Camp, A, Lopes, R, Egydio, F, Kawakami, A, Oliveira, J, Wozniak, J, Matthews, A, Ratky, C, Valiris, J, Berdan, L, Hepditch, A, Quintero, K, Rorick, T, Westbrook, M, Pascual, A, Rovito, C, Bezault, M, Drouet, E, Simon, T, Alsweiler, C, Luyten, A, Aylward, P, Butters, J, Griffith, L, Shaw, M, Hagstrom, E, Grunberg, L, Islam, S, Bregeault, MF, Bougon, N, Faustino, D, Fontecave, S, Murphy, J, Tamby, JF, Verrier, M, Agnetti, V, Andersen, D, Badreddine, E, Bekkouche, M, Bouancheau, C, Brigui, I, Brocklehurst, M, Cianciarulo, J, Devaul, D, Domokos, S, Gache, C, Gobillot, C, Guillou, S, Healy, J, Heath, M, Jaiwal, G, Javierre, C, Labeirie, J, Monier, M, Morales, U, Mrabti, A, Mthombeni, B, Okan, B, Smith, L, Sheller, J, Sopena, S, Pellan, V, Benbernou, F, Bengrait, N, Lamoureux, M, Kralova, K, Scemama, M, Bejuit, R, Coulange, A, Berthou, C, Repincay, J, Lorenzato, C, Etienne, A, Gouet, V, Loizeau, V, Normand, M, Ourliac, A, Rondel, C, Adamo, A, Beltran, P, Barraud, P, Dubois-Gache, H, Halle, B, Metwally, L, Mourgues, M, Sotty, M, Vincendet, M, Cotruta, R, Zhu, CY, Fournie-Lloret, D, Morrello, C, Perthuis, A, Picault, P, Zobouyan, I, ODYSSEY OUTCOMES Comm Inve, Ege Üniversitesi, Cardiology, and Internal Medicine
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medicine.medical_specialty ,Acute coronary syndrome ,Time Factors ,acute coronary syndrome ,alirocumab ,global burden of disease ,hospitalization ,myocardial infarction ,PCSK9 ,030204 cardiovascular system & hematology ,Antibodies, Monoclonal, Humanized ,Placebo ,Patient Readmission ,Risk Assessment ,03 medical and health sciences ,Patient Admission ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Angina, Unstable ,Hospital Mortality ,030212 general & internal medicine ,Myocardial infarction ,03.02. Klinikai orvostan ,Dyslipidemias ,Alirocumab ,Out of hospital ,business.industry ,Anticholesteremic Agents ,Cholesterol, HDL ,Cholesterol hdl ,Cholesterol, LDL ,medicine.disease ,Treatment Outcome ,Drug Therapy, Combination ,Human medicine ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business ,Cardiovascular outcomes ,Biomarkers - Abstract
Sherwood, Matthew/0000-0002-4305-5883; Abbate, Antonio/0000-0002-1930-785X; Moris, Cesar/0000-0002-2871-190X; Ersanli, Murat/0000-0003-1847-3087; Taskinen, Marja-Riitta/0000-0002-6229-3588; bastos, jose/0000-0002-9526-3123; Reshetko, Olga/0000-0003-3107-7636; Nikolaev, Konstantin/0000-0003-4601-6203; Leonardi, Sergio/0000-0002-4800-6132; Raffel, Owen C/0000-0001-5470-7050; Racca, Vittorio/0000-0002-4465-3789; Podoleanu, Cristian/0000-0001-9987-2519; Gislason, Gunnar H/0000-0002-0548-402X; Muenzel, Thomas/0000-0001-5503-4150; Tse, Hung Fat/0000-0002-9578-7808; Chumakova, Galina A/0000-0002-2810-6531, WOS: 000502609000004, PubMed: 31707826, Background: in ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), alirocumab was compared with placebo, added to high-intensity or maximum tolerated statin treatment after acute coronary syndrome in 18924 patients. Alirocumab reduced first occurrence of the primary composite end point-coronary heart disease death, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or hospitalization for unstable angina-as well as total nonfatal cardiovascular events and all-cause deaths. the present analysis determined whether alirocumab reduced total (first and subsequent) hospitalizations and death and increased days alive and out of hospital (DAOH) and percent DAOH in ODYSSEY OUTCOMES. Methods and Results: in prespecified analyses, hazard functions for total hospitalizations and death were jointly estimated by a semiparametric model, while in post hoc analyses, DAOH and percent DAOH were compared between treatment groups with Poisson regression and one-inflated beta regression, respectively. With 16629 total hospitalizations and 726 deaths, 331 fewer hospitalizations, and 58 fewer deaths were observed with alirocumab compared with placebo, translating to 15.6 total hospitalizations or deaths avoided with alirocumab per 1000 patient-years of assigned treatment. Alirocumab reduced total hospitalizations (hazard ratio, 0.96 [95% CI, 0.92-1.00]; P=0.04) and increased DAOH relative to placebo (rate ratio, 1.003 [95% CI, 1.000-1.007]; P=0.05), primarily through a reduction in days dead (rate ratio, 0.847 [95% CI, 0.728-0.986]; P=0.03). Patients randomized to alirocumab were also more likely to survive to the end of the study without hospitalization (odds ratio, 1.06 [95% CI, 1.00-1.13]; P=0.03). Conclusions: Alirocumab reduced total hospitalizations with corresponding small increases in DAOH and percent DAOH. These outcomes provide alternative patient-centered metrics to capture the totality of alirocumab clinical efficacy after acute coronary syndrome. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01663402., Fondation Assistance Publique-Hopitaux de Paris, Paris, France, We thank the patients, study coordinators, and investigators who participated in this trial. Sophie Rushton-Smith, PhD (MedLink Healthcare Communications, London) provided editorial assistance in the preparation of the article (limited to editing for style, referencing, and figure and table editing) and was funded by Fondation Assistance Publique-Hopitaux de Paris, Paris, France.
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- 2019
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34. A PILOT STUDY OF ATTITUDES TOWARDS BLOOD DONATION IN ASIAN STUDENTS.
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Doughty, H A, Ling, Yi, and Mendis, S
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- 1999
35. The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project
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Hobbs, MST, Jamrozik, K., Thompson, PL, Armstrong, BK, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L., De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L., Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, HE, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F., Beck, D, Wunsch, G., Bertrand, F., van Houte, M., Rime, B., Rorive, G, Hannot, R., Adrienne, A, Luyckx, A, Wolf, HK, Gregor, RD, Bata, IR, Brownell, B., Webber, K, Skodova´, Z, Pisa, Z., Berka, L., Cicha, Z., Cerovska´, J, Emrova´, R, Hoke, M, Hronkova, M., Pikhartova´, J., Grafnetter, D., Poledne, R., Vojtisek, P., Vorlicek, J., Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A., Quitsau Lund, S, Tuomilehto, J, Puska, P., Vartiainen, E., Korhonen, H., Jousilahti, M, Ducimetie`re, P, Richard, JL, Bingham, A., Lang, T, Amouyel, P, Cottel, D., Nuttens, MC, Marecaux, N., Dallongeville, J., Salomez, J. L., Montaye, M., Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N., Savouret, M, Houset, M., Pierau, F., Goetz, V, Ferrie`res, J, Ruidavets, JB, Cambou, JP, Rodier, P., Saulet, C, Greiser, E., Herman, B., Stu¨demann, G, Nu¨ssel, E., Osto¨r Lamm, E., Scheidt, R., Morgenstern, W., Stadler, M, Ganova, M, Keil, U, Tietze, M., Banos, R., Do¨ring, A., Filipiak, B, Barth, W, Heinemann, L, Muche, J., Schmalfuss, S., Assmann, A., Bo¨thig, S., Voigt, G., Brasche, S., Quietzsch, D., Classen, E, Sigfu´sson, N, Gudmundsdo´ttir, II, Stefa´nsdo´ttir, I, Thorsteinsson, T., Sigvaldason H, Menotti, A, Giampaoli, S., Verdecchia, A, Righetti, G., De Pasquale, B., Di Raimo, P, Forte, E., Majetta, A, Vanuzzo, D, Feruglio, GA, Pilotto, L., Cignacco, G., Marini, R., Zilio, G, Cesana, GC, Ferrario, M, Sega, R., Mocarelli, P, BRAMBILLA, PAOLO, Bluzhas, J, Domarkiene, S., Tamosiunas, A., Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A., Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E., Pazucha, T., Malczewska, M., Mo´rawska, I, Rywik, SL, Broda,V, Polakowska, M., Kurjata, P, Varlamova, A, Britov, A., Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y.u. P, Malyutina, S., Gafarov, V, Feigin, V, Sans, S., Balaguer Vintro´, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode´s, A, Wilhelmsen, L, Harmsen, P., Rosengren, A., Lappas, G, Asplund, K., Huhtasaari, F., Stegmayr, B., Lundberg V, Gutzwiller, F, Paccaud, F., Rickenbach, M., Wietlisbach, V., Barazzoni, F, Mainieri, F., Tullen, B, Evans, V, McCrum, EE, Falconer, T, Cashman, S., Patterson, C., Kerr, M., O’Reilly, D., Scott, A., McConville, M., McMillan, I., McMaster, D, Tunstall Pedoe, H., Smith, WCS, Tavendale, R., Crombie, V, Barrett, K., Brown, C., Shewry, M., Hannh, M. K, Morrisson, C, Planojevic, M, Jakovljevic, D., Svircevic, A., Mirilov, V., Strasser, V., Mendis, S., Martin8, I, Gyarfas8, V, Pı´_sa8, V, Dodu8, S. R. A., Bo¨thig8, S., Watson, M. J., Hill, M., Price, A, Kuulasmaa, K., Tuomilehto, J., Ruokokoski, E, Rajakangas, A. M., Ma¨kinen, M., Virman Ojanen, T, Palonen, L., Akkila, J, Cepaitis, Z., Molarius, A., Moltchanov, V., Tolonen, H, Grafnetter, D, Dobson, A., Fortmann, SP, Shatchkute, A, Zaitsev, V, Epstein, FH, Feinleib, M, Karvonen, MJ, Prineas, RJ, Williams, OD, Hobbs, M, Jamrozik, K, Thompson, P, Armstrong, B, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L, De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L, Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, H, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F, Beck, D, Wunsch, G, Bertrand, F, van Houte, M, Rime, B, Rorive, G, Hannot, R, Adrienne, A, Luyckx, A, Wolf, H, Gregor, R, Bata, I, Brownell, B, Webber, K, Skodova´, Z, Pisa, Z, Berka, L, Cicha, Z, Cerovska´, J, Emrova´, R, Hoke, M, Hronkova, M, Pikhartova´, J, Grafnetter, D, Poledne, R, Vojtisek, P, Vorlicek, J, Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A, Quitsau Lund, S, Tuomilehto, J, Puska, P, Vartiainen, E, Korhonen, H, Jousilahti, M, Ducimetie`re, P, Richard, J, Bingham, A, Lang, T, Amouyel, P, Cottel, D, Nuttens, M, Marecaux, N, Dallongeville, J, Salomez, J, Montaye, M, Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N, Savouret, M, Houset, M, Pierau, F, Goetz, V, Ferrie`res, J, Ruidavets, J, Cambou, J, Rodier, P, Saulet, C, Greiser, E, Herman, B, Stu¨demann, G, Nu¨ssel, E, Osto¨r Lamm, E, Scheidt, R, Morgenstern, W, Stadler, M, Ganova, M, Keil, U, Tietze, M, Banos, R, Do¨ring, A, Filipiak, B, Barth, W, Heinemann, L, Muche, J, Schmalfuss, S, Assmann, A, Bo¨thig, S, Voigt, G, Brasche, S, Quietzsch, D, Classen, E, Sigfu´sson, N, Gudmundsdo´ttir, I, Stefa´nsdo´ttir, I, Thorsteinsson, T, Sigvaldason, H, Menotti, A, Giampaoli, S, Verdecchia, A, Righetti, G, De Pasquale, B, Di Raimo, P, Forte, E, Majetta, A, Vanuzzo, D, Feruglio, G, Pilotto, L, Cignacco, G, Marini, R, Zilio, G, Cesana, G, Ferrario, M, Sega, R, Mocarelli, P, Brambilla, P, Bluzhas, J, Domarkiene, S, Tamosiunas, A, Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A, Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E, Pazucha, T, Malczewska, M, Mo´rawska, I, Rywik, S, Broda, V, Polakowska, M, Kurjata, P, Varlamova, A, Britov, A, Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y, Malyutina, S, Gafarov, V, Feigin, V, Sans, S, Balaguer Vintro´, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode´s, A, Wilhelmsen, L, Harmsen, P, Rosengren, A, Lappas, G, Asplund, K, Huhtasaari, F, Stegmayr, B, Lundberg, V, Gutzwiller, F, Paccaud, F, Rickenbach, M, Wietlisbach, V, Barazzoni, F, Mainieri, F, Tullen, B, Evans, V, Mccrum, E, Falconer, T, Cashman, S, Patterson, C, Kerr, M, O’Reilly, D, Scott, A, Mcconville, M, Mcmillan, I, Mcmaster, D, Tunstall Pedoe, H, Smith, W, Tavendale, R, Crombie, V, Barrett, K, Brown, C, Shewry, M, Hannh, M, Morrisson, C, Planojevic, M, Jakovljevic, D, Svircevic, A, Mirilov, V, Strasser, V, Mendis, S, Martin8, I, Gyarfas8, V, Pı´_sa8, V, Dodu8, S, Bo¨thig8, S, Watson, M, Hill, M, Price, A, Kuulasmaa, K, Ruokokoski, E, Rajakangas, A, Ma¨kinen, M, Virman Ojanen, T, Palonen, L, Akkila, J, Cepaitis, Z, Molarius, A, Moltchanov, V, Tolonen, H, Dobson, A, Fortmann, S, Shatchkute, A, Zaitsev, V, Epstein, F, Feinleib, M, Karvonen, M, Prineas, R, and Williams, O
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Adult ,Male ,Canada ,medicine.medical_specialty ,BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA ,Waist ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,Logistic regression ,Body Mass Index ,Risk Factors ,Internal medicine ,Prevalence ,medicine ,Humans ,Triglycerides ,Abdominal obesity ,Adiposity ,Dyslipidemias ,Nutrition and Dietetics ,business.industry ,Cholesterol, HDL ,Smoking ,Australia ,nutritional and metabolic diseases ,Cholesterol, LDL ,Middle Aged ,medicine.disease ,Health Surveys ,Europe ,Menopause ,Cross-Sectional Studies ,Logistic Models ,Endocrinology ,Dyslipidemia ,Quartile ,Obesity, Abdominal ,Female ,Waist Circumference ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Body mass index ,New Zealand ,Demography - Abstract
Background and aims: The association between adiposity measures and dyslipidemia has seldom been assessed in a multipopulational setting. Methods and results: 27 populations from Europe, Australia, New Zealand and Canada (WHO MONICA project) using health surveys conducted between 1990 and 1997 in adults aged 35-64 years (n = 40,480). Dyslipidemia was defined as the total/HDL cholesterol ratio >6 (men) and >5 (women).Overall prevalence of dyslipidemia was 25% in men and 23% in women. Logistic regression showed that dyslipidemia was strongly associated with body mass index (BMI) in men and with waist circumference (WC) in women, after adjusting for region, age and smoking. Among normal-weight men and women (BMI84.8 cm) in normal-weight men, menopause in women and regular smoking further defined subgroups at increased risk. Conclusion: standard categories of BMI and WC, or their combinations, do not lead to optimal risk stratification for dyslipidemia in middle-age adults. Sex-specific adaptations are necessary, in particular by taking into account abdominal obesity in normal-weight men, post-menopausal age in women and regular smoking in both sexes
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- 2013
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36. World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions
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Kaptoge, S, Pennells, L, De Bacquer, D, Cooney, MT, Kavousi, M, Stevens, G, Riley, LM, Savin, S, Khan, T, Altay, S, Amouyel, P, Assmann, G, Bell, S, Ben-Shlomo, Y, Berkman, L, Beulens, JW, Björkelund, C, Blaha, M, Blazer, DG, Bolton, T, Bonita Beaglehole, R, Brenner, H, Brunner, EJ, Casiglia, E, Chamnan, P, Choi, YH, Chowdry, R, Coady, S, Crespo, CJ, Cushman, M, Dagenais, GR, D'Agostino, RB, Daimon, M, Davidson, KW, Engström, G, Ford, I, Gallacher, J, Gansevoort, RT, Gaziano, TA, Giampaoli, S, Grandits, G, Grimsgaard, S, Grobbee, DE, Gudnason, V, Guo, Q, Tolonen, H, Humphries, S, Iso, H, Jukema, JW, Kauhanen, J, Kengne, AP, Khalili, D, Koenig, W, Kromhout, D, Krumholz, H, Lam, TH, Laughlin, G, Marín Ibañez, A, Meade, TW, Moons, KGM, Nietert, PJ, Ninomiya, T, Nordestgaard, BG, O'Donnell, C, Palmieri, L, Patel, A, Perel, P, Price, JF, Providencia, R, Ridker, PM, Rodriguez, B, Rosengren, A, Roussel, R, Sakurai, M, Salomaa, V, Sato, S, Schöttker, B, Shara, N, Shaw, JE, Shin, HC, Simons, LA, Sofianopoulou, E, Sundström, J, Völzke, H, Wallace, RB, Wareham, NJ, Willeit, P, Wood, D, Wood, A, Zhao, D, Woodward, M, Danaei, G, Roth, G, Mendis, S, Onuma, O, Varghese, C, Ezzati, M, Graham, I, Jackson, R, Danesh, J, Kaptoge, S, Pennells, L, De Bacquer, D, Cooney, MT, Kavousi, M, Stevens, G, Riley, LM, Savin, S, Khan, T, Altay, S, Amouyel, P, Assmann, G, Bell, S, Ben-Shlomo, Y, Berkman, L, Beulens, JW, Björkelund, C, Blaha, M, Blazer, DG, Bolton, T, Bonita Beaglehole, R, Brenner, H, Brunner, EJ, Casiglia, E, Chamnan, P, Choi, YH, Chowdry, R, Coady, S, Crespo, CJ, Cushman, M, Dagenais, GR, D'Agostino, RB, Daimon, M, Davidson, KW, Engström, G, Ford, I, Gallacher, J, Gansevoort, RT, Gaziano, TA, Giampaoli, S, Grandits, G, Grimsgaard, S, Grobbee, DE, Gudnason, V, Guo, Q, Tolonen, H, Humphries, S, Iso, H, Jukema, JW, Kauhanen, J, Kengne, AP, Khalili, D, Koenig, W, Kromhout, D, Krumholz, H, Lam, TH, Laughlin, G, Marín Ibañez, A, Meade, TW, Moons, KGM, Nietert, PJ, Ninomiya, T, Nordestgaard, BG, O'Donnell, C, Palmieri, L, Patel, A, Perel, P, Price, JF, Providencia, R, Ridker, PM, Rodriguez, B, Rosengren, A, Roussel, R, Sakurai, M, Salomaa, V, Sato, S, Schöttker, B, Shara, N, Shaw, JE, Shin, HC, Simons, LA, Sofianopoulou, E, Sundström, J, Völzke, H, Wallace, RB, Wareham, NJ, Willeit, P, Wood, D, Wood, A, Zhao, D, Woodward, M, Danaei, G, Roth, G, Mendis, S, Onuma, O, Varghese, C, Ezzati, M, Graham, I, Jackson, R, and Danesh, J
- Abstract
Background: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. Methods: In this model revision initiative, we derived 10-year risk prediction models for fatal and non-fatal cardiovascular disease (ie, myocardial infarction and stroke) using individual participant data from the Emerging Risk Factors Collaboration. Models included information on age, smoking status, systolic blood pressure, history of diabetes, and total cholesterol. For derivation, we included participants aged 40–80 years without a known baseline history of cardiovascular disease, who were followed up until the first myocardial infarction, fatal coronary heart disease, or stroke event. We recalibrated models using age-specific and sex-specific incidences and risk factor values available from 21 global regions. For external validation, we analysed individual participant data from studies distinct from those used in model derivation. We illustrated models by analysing data on a further 123 743 individuals from surveys in 79 countries collected with the WHO STEPwise Approach to Surveillance. Findings: Our risk model derivation involved 376 177 individuals from 85 cohorts, and 19 333 incident cardiovascular events recorded during 10 years of follow-up. The derived risk prediction models discriminated well in external validation cohorts (19 cohorts, 1 096 061 individuals, 25 950 cardiovascular disease events), with Harrell's C indices ranging from 0·685 (95% CI 0·629–0·741) to 0·833 (0·783–0·882). For a given risk factor profile, we found substantial variation across global regions in the estimated 10-year predicted risk. For example, estimated cardiovascular disease risk for a
- Published
- 2019
37. Right versus left sided metastatic colorectal cancer: Teasing out clinicopathologic drivers of disparity in survival
- Author
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Mendis, S, Beck, S, Lee, B, Lee, M, Wong, R, Kosmider, S, Shapiro, J, Yip, D, Steel, S, Nott, L, Jennens, R, Lipton, L, Burge, M, Field, K, Ananda, S, Wong, H-L, Gibbs, P, Mendis, S, Beck, S, Lee, B, Lee, M, Wong, R, Kosmider, S, Shapiro, J, Yip, D, Steel, S, Nott, L, Jennens, R, Lipton, L, Burge, M, Field, K, Ananda, S, Wong, H-L, and Gibbs, P
- Abstract
BACKGROUND: Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute. METHODS: The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectively captured data on consecutive mCRC patients. RC were defined as tumors proximal to the splenic flexure; LC were those at and distal to the splenic flexure and included rectal cancers. Patient, tumor, treatment, and survival data were analyzed stratified by side. RESULTS: Of 2306 patients enrolled from July 2009-March 2018, 747 (32%) had an RC. Patients with RC were older, more likely to be female and have a Charlson score ≥3. RC were more frequently BRAF mutated, deficient in mismatch repair, associated with peritoneal metastases, and less likely to receive chemotherapy. Progression-free survival on first-line systemic therapy was inferior for RC patients (8.1 vs. 10.8 months, hazard ratio [HR] for progression in RC 1.38, P < 0.001). Median overall survival for all RC patients was inferior (19.6 vs. 27.5 months, HR for death in RC 1.44, P < 0.001), and inferior within the treated (21 vs. 29.5 months, HR 1.52, P < 0.001) and untreated subgroups (5.9 vs. 10.3 months, HR 1.38, P = 0.009). Primary side remained a significant factor for overall survival in multivariate analysis. CONCLUSION: Our data from a real-world population confirms the poorer prognosis associated with RC. Primary tumor location remains significantly associated with overall survival even when adjusting for multiple factors, indicating the existence of further side-based differences that are as yet undefined.
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- 2019
38. Development of CMOS Active Pixel Image Sensors for Low Cost Commercial Applications
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Gee, R, Kemeny, S, Kim, Q, Mendis, S, Nakamura, J, Nixon, R, Ortiz, M, Pain, B, Staller, C, Zhou, Z, and Fossum, E
- Published
- 1994
39. Development of CMOS Active Pixel Image Sensors for Low Cost Commercial Applications
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Fossum, E, Gee, R, Kemeny, S, Kim, Q, Mendis, S, Nakamura, J, Nixon, R, Ortiz, M, Pain, B, Zhou, Z, Ackland, B, Dickinson, A, Eid, E, and Inglis, D
- Published
- 1994
40. Progress in CMOS Active Pixel Image Sensors
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Fossum, E, Kim, Q, Pain, B, Gee, R, Kemeny, S, and Mendis, S
- Abstract
Recent research results regarding the investigation of CMOS active pixel image sensors (APS) are reported. An investigation of various designs for the pixel, including photogate devices of various geometries and photodiode devices has been performed. Opto-electronic performance including intra-pixel photoresponse maps taken using a focused laser scanning apparatus are presented. Several imaging arrays have also been investigated. A 128 x 128 image sensor has been fabricated and characterized. Both p-well and n-well implementations have been explored. The demonstrated arrays use 2 micron CMOS design rules and have a 40 x 40 micron pixel pitch.
- Published
- 1994
41. Progress in CMOS Active Pixel Image Sensors
- Author
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Mendis, S, Kemeny, S, Gee, R, Pain, B, Kim, Q, and Fossum, E
- Published
- 1994
42. CMOS Active Pixel Image Sensors for Highly Integrated Imaging Systems
- Author
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Mendis, S. K, Kemeny, S. E, Gee, R. C, Kim, B, and Fossum, E. R
- Subjects
Electronics And Electrical Engineering - Abstract
A family of CMOS-based active pixel image sensors (APS) that are inherently compatible with the integration of on-chip signal processing circuitry is reported.
- Published
- 1994
43. The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project
- Author
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Hobbs, M, Jamrozik, K, Thompson, P, Armstrong, B, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L, De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L, Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, H, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F, Beck, D, Wunsch, G, Bertrand, F, van Houte, M, Rime, B, Rorive, G, Hannot, R, Adrienne, A, Luyckx, A, Wolf, H, Gregor, R, Bata, I, Brownell, B, Webber, K, Skodova ́, Z, Pisa, Z, Berka, L, Cicha, Z, Cerovska ́, J, Emrova ́, R, Hoke, M, Hronkova, M, Pikhartova ́, J, Grafnetter, D, Poledne, R, Vojtisek, P, Vorlicek, J, Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A, Quitsau Lund, S, Tuomilehto, J, Puska, P, Vartiainen, E, Korhonen, H, Jousilahti, M, Ducimetie`re, P, Richard, J, Bingham, A, Lang, T, Amouyel, P, Cottel, D, Nuttens, M, Marecaux, N, Dallongeville, J, Salomez, J, Montaye, M, Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N, Savouret, M, Houset, M, Pierau, F, Goetz, V, Ferrie`res, J, Ruidavets, J, Cambou, J, Rodier, P, Saulet, C, Greiser, E, Herman, B, Stu ̈demann, G, Nu ̈ssel, E, Osto ̈r Lamm, E, Scheidt, R, Morgenstern, W, Stadler, M, Ganova, M, Keil, U, Tietze, M, Banos, R, Do ̈ring, A, Filipiak, B, Barth, W, Heinemann, L, Muche, J, Schmalfuss, S, Assmann, A, Bo ̈thig, S, Voigt, G, Brasche, S, Quietzsch, D, Classen, E, Sigfu ́sson, N, Gudmundsdo ́ttir, I, Stefa ́nsdo ́ttir, I, Thorsteinsson, T, Sigvaldason, H, Menotti, A, Giampaoli, S, Verdecchia, A, Righetti, G, De Pasquale, B, Di Raimo, P, Forte, E, Majetta, A, Vanuzzo, D, Feruglio, G, Pilotto, L, Cignacco, G, Marini, R, Zilio, G, Cesana, G, Ferrario, M, Sega, R, Mocarelli, P, Brambilla, P, Bluzhas, J, Domarkiene, S, Tamosiunas, A, Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A, Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E, Pazucha, T, Malczewska, M, Mo ́rawska, I, Rywik, S, Broda, V, Polakowska, M, Kurjata, P, Varlamova, A, Britov, A, Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y, Malyutina, S, Gafarov, V, Feigin, V, Sans, S, Balaguer Vintro ́, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode ́s, A, Wilhelmsen, L, Harmsen, P, Rosengren, A, Lappas, G, Asplund, K, Huhtasaari, F, Stegmayr, B, Lundberg, V, Gutzwiller, F, Paccaud, F, Rickenbach, M, Wietlisbach, V, Barazzoni, F, Mainieri, F, Tullen, B, Evans, V, Mccrum, E, Falconer, T, Cashman, S, Patterson, C, Kerr, M, O’Reilly, D, Scott, A, Mcconville, M, Mcmillan, I, Mcmaster, D, Tunstall Pedoe, H, Smith, W, Tavendale, R, Crombie, V, Barrett, K, Brown, C, Shewry, M, Hannh, M, Morrisson, C, Planojevic, M, Jakovljevic, D, Svircevic, A, Mirilov, V, Strasser, V, Mendis, S, Martin8, I, Gyarfas8, V, Pı ́_sa8, V, Dodu8, S, Bo ̈thig8, S, Watson, M, Hill, M, Price, A, Kuulasmaa, K, Ruokokoski, E, Rajakangas, A, Ma ̈kinen, M, Virman Ojanen, T, Palonen, L, Akkila, J, Cepaitis, Z, Molarius, A, Moltchanov, V, Tolonen, H, Dobson, A, Fortmann, S, Shatchkute, A, Zaitsev, V, Epstein, F, Feinleib, M, Karvonen, M, Prineas, R, Williams, O, Hobbs, MST, Jamrozik, K., Thompson, PL, Armstrong, BK, Van Parys, L., Berghmans, L., Kulbertus, HE, Lefebvre, F., Wunsch, G., Bertrand, F., van Houte, M., Rime, B., Hannot, R., Wolf, HK, Gregor, RD, Bata, IR, Brownell, B., Pisa, Z., Berka, L., Cicha, Z., Hronkova, M., Pikhartova ́, J., Grafnetter, D., Poledne, R., Vojtisek, P., Vorlicek, J., Sjøl, A., Puska, P., Vartiainen, E., Korhonen, H., Richard, JL, Bingham, A., Cottel, D., Nuttens, MC, Marecaux, N., Dallongeville, J., Salomez, J. L., Montaye, M., Lamamy, N., Houset, M., Pierau, F., Ruidavets, JB, Cambou, JP, Rodier, P., Greiser, E., Herman, B., Nu ̈ssel, E., Osto ̈r Lamm, E., Scheidt, R., Morgenstern, W., Tietze, M., Banos, R., Do ̈ring, A., Muche, J., Schmalfuss, S., Assmann, A., Bo ̈thig, S., Voigt, G., Brasche, S., Quietzsch, D., Gudmundsdo ́ttir, II, Thorsteinsson, T., Sigvaldason H, Giampaoli, S., Righetti, G., De Pasquale, B., Forte, E., Feruglio, GA, Pilotto, L., Cignacco, G., Marini, R., Cesana, GC, Sega, R., BRAMBILLA, PAOLO, Domarkiene, S., Tamosiunas, A., Stewart, A., Kawalec, E., Pazucha, T., Malczewska, M., Rywik, SL, Broda,V, Polakowska, M., Britov, A., Nikitin, Y.u. P, Malyutina, S., Sans, S., Harmsen, P., Rosengren, A., Asplund, K., Huhtasaari, F., Stegmayr, B., Lundberg V, Paccaud, F., Rickenbach, M., Wietlisbach, V., Mainieri, F., McCrum, EE, Cashman, S., Patterson, C., Kerr, M., O’Reilly, D., Scott, A., McConville, M., McMillan, I., McMaster, D, Tunstall Pedoe, H., Smith, WCS, Tavendale, R., Barrett, K., Brown, C., Shewry, M., Hannh, M. K, Jakovljevic, D., Svircevic, A., Mirilov, V., Strasser, V., Mendis, S., Dodu8, S. R. A., Bo ̈thig8, S., Watson, M. J., Hill, M., Kuulasmaa, K., Tuomilehto, J., Rajakangas, A. M., Ma ̈kinen, M., Palonen, L., Cepaitis, Z., Molarius, A., Moltchanov, V., Dobson, A., Fortmann, SP, Epstein, FH, Karvonen, MJ, Prineas, RJ, Williams, OD, Hobbs, M, Jamrozik, K, Thompson, P, Armstrong, B, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L, De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L, Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, H, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F, Beck, D, Wunsch, G, Bertrand, F, van Houte, M, Rime, B, Rorive, G, Hannot, R, Adrienne, A, Luyckx, A, Wolf, H, Gregor, R, Bata, I, Brownell, B, Webber, K, Skodova ́, Z, Pisa, Z, Berka, L, Cicha, Z, Cerovska ́, J, Emrova ́, R, Hoke, M, Hronkova, M, Pikhartova ́, J, Grafnetter, D, Poledne, R, Vojtisek, P, Vorlicek, J, Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A, Quitsau Lund, S, Tuomilehto, J, Puska, P, Vartiainen, E, Korhonen, H, Jousilahti, M, Ducimetie`re, P, Richard, J, Bingham, A, Lang, T, Amouyel, P, Cottel, D, Nuttens, M, Marecaux, N, Dallongeville, J, Salomez, J, Montaye, M, Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N, Savouret, M, Houset, M, Pierau, F, Goetz, V, Ferrie`res, J, Ruidavets, J, Cambou, J, Rodier, P, Saulet, C, Greiser, E, Herman, B, Stu ̈demann, G, Nu ̈ssel, E, Osto ̈r Lamm, E, Scheidt, R, Morgenstern, W, Stadler, M, Ganova, M, Keil, U, Tietze, M, Banos, R, Do ̈ring, A, Filipiak, B, Barth, W, Heinemann, L, Muche, J, Schmalfuss, S, Assmann, A, Bo ̈thig, S, Voigt, G, Brasche, S, Quietzsch, D, Classen, E, Sigfu ́sson, N, Gudmundsdo ́ttir, I, Stefa ́nsdo ́ttir, I, Thorsteinsson, T, Sigvaldason, H, Menotti, A, Giampaoli, S, Verdecchia, A, Righetti, G, De Pasquale, B, Di Raimo, P, Forte, E, Majetta, A, Vanuzzo, D, Feruglio, G, Pilotto, L, Cignacco, G, Marini, R, Zilio, G, Cesana, G, Ferrario, M, Sega, R, Mocarelli, P, Brambilla, P, Bluzhas, J, Domarkiene, S, Tamosiunas, A, Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A, Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E, Pazucha, T, Malczewska, M, Mo ́rawska, I, Rywik, S, Broda, V, Polakowska, M, Kurjata, P, Varlamova, A, Britov, A, Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y, Malyutina, S, Gafarov, V, Feigin, V, Sans, S, Balaguer Vintro ́, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode ́s, A, Wilhelmsen, L, Harmsen, P, Rosengren, A, Lappas, G, Asplund, K, Huhtasaari, F, Stegmayr, B, Lundberg, V, Gutzwiller, F, Paccaud, F, Rickenbach, M, Wietlisbach, V, Barazzoni, F, Mainieri, F, Tullen, B, Evans, V, Mccrum, E, Falconer, T, Cashman, S, Patterson, C, Kerr, M, O’Reilly, D, Scott, A, Mcconville, M, Mcmillan, I, Mcmaster, D, Tunstall Pedoe, H, Smith, W, Tavendale, R, Crombie, V, Barrett, K, Brown, C, Shewry, M, Hannh, M, Morrisson, C, Planojevic, M, Jakovljevic, D, Svircevic, A, Mirilov, V, Strasser, V, Mendis, S, Martin8, I, Gyarfas8, V, Pı ́_sa8, V, Dodu8, S, Bo ̈thig8, S, Watson, M, Hill, M, Price, A, Kuulasmaa, K, Ruokokoski, E, Rajakangas, A, Ma ̈kinen, M, Virman Ojanen, T, Palonen, L, Akkila, J, Cepaitis, Z, Molarius, A, Moltchanov, V, Tolonen, H, Dobson, A, Fortmann, S, Shatchkute, A, Zaitsev, V, Epstein, F, Feinleib, M, Karvonen, M, Prineas, R, Williams, O, Hobbs, MST, Jamrozik, K., Thompson, PL, Armstrong, BK, Van Parys, L., Berghmans, L., Kulbertus, HE, Lefebvre, F., Wunsch, G., Bertrand, F., van Houte, M., Rime, B., Hannot, R., Wolf, HK, Gregor, RD, Bata, IR, Brownell, B., Pisa, Z., Berka, L., Cicha, Z., Hronkova, M., Pikhartova ́, J., Grafnetter, D., Poledne, R., Vojtisek, P., Vorlicek, J., Sjøl, A., Puska, P., Vartiainen, E., Korhonen, H., Richard, JL, Bingham, A., Cottel, D., Nuttens, MC, Marecaux, N., Dallongeville, J., Salomez, J. L., Montaye, M., Lamamy, N., Houset, M., Pierau, F., Ruidavets, JB, Cambou, JP, Rodier, P., Greiser, E., Herman, B., Nu ̈ssel, E., Osto ̈r Lamm, E., Scheidt, R., Morgenstern, W., Tietze, M., Banos, R., Do ̈ring, A., Muche, J., Schmalfuss, S., Assmann, A., Bo ̈thig, S., Voigt, G., Brasche, S., Quietzsch, D., Gudmundsdo ́ttir, II, Thorsteinsson, T., Sigvaldason H, Giampaoli, S., Righetti, G., De Pasquale, B., Forte, E., Feruglio, GA, Pilotto, L., Cignacco, G., Marini, R., Cesana, GC, Sega, R., BRAMBILLA, PAOLO, Domarkiene, S., Tamosiunas, A., Stewart, A., Kawalec, E., Pazucha, T., Malczewska, M., Rywik, SL, Broda,V, Polakowska, M., Britov, A., Nikitin, Y.u. P, Malyutina, S., Sans, S., Harmsen, P., Rosengren, A., Asplund, K., Huhtasaari, F., Stegmayr, B., Lundberg V, Paccaud, F., Rickenbach, M., Wietlisbach, V., Mainieri, F., McCrum, EE, Cashman, S., Patterson, C., Kerr, M., O’Reilly, D., Scott, A., McConville, M., McMillan, I., McMaster, D, Tunstall Pedoe, H., Smith, WCS, Tavendale, R., Barrett, K., Brown, C., Shewry, M., Hannh, M. K, Jakovljevic, D., Svircevic, A., Mirilov, V., Strasser, V., Mendis, S., Dodu8, S. R. A., Bo ̈thig8, S., Watson, M. J., Hill, M., Kuulasmaa, K., Tuomilehto, J., Rajakangas, A. M., Ma ̈kinen, M., Palonen, L., Cepaitis, Z., Molarius, A., Moltchanov, V., Dobson, A., Fortmann, SP, Epstein, FH, Karvonen, MJ, Prineas, RJ, and Williams, OD
- Abstract
Background and aims: The association between adiposity measures and dyslipidemia has seldom been assessed in a multipopulational setting. Methods and results: 27 populations from Europe, Australia, New Zealand and Canada (WHO MONICA project) using health surveys conducted between 1990 and 1997 in adults aged 35-64 years (n = 40,480). Dyslipidemia was defined as the total/HDL cholesterol ratio >6 (men) and >5 (women).Overall prevalence of dyslipidemia was 25% in men and 23% in women. Logistic regression showed that dyslipidemia was strongly associated with body mass index (BMI) in men and with waist circumference (WC) in women, after adjusting for region, age and smoking. Among normal-weight men and women (BMI<25 kg/m2), an increase in the odds for being dyslipidemic was observed between lowest and highest WC quartiles (OR = 3.6, p < 0.001). Among obese men (BMI ≥ 30), the corresponding increase was smaller (OR = 1.2, p = 0.036). A similar weakening was observed among women. Classification tree analysis was performed to assign subjects into classes of risk for dyslipidemia. BMI thresholds (25.4 and 29.2 kg/m2) in men and WC thresholds (81.7 and 92.6 cm) in women came out at first stages. High WC (>84.8 cm) in normal-weight men, menopause in women and regular smoking further defined subgroups at increased risk. Conclusion: standard categories of BMI and WC, or their combinations, do not lead to optimal risk stratification for dyslipidemia in middle-age adults. Sex-specific adaptations are necessary, in particular by taking into account abdominal obesity in normal-weight men, post-menopausal age in women and regular smoking in both sexes
- Published
- 2013
44. Splenic Syndrome in a Young Man at High Altitude with Undetected Sickle Cell Trait
- Author
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Fernando, CHKA, primary, Mendis, S, additional, Upasena, AP, additional, Costa, YJ, additional, Williams, HS, additional, and Moratuwagama, D, additional
- Published
- 2017
- Full Text
- View/download PDF
45. Causes and consequences of depression in multiple sclerosis
- Author
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Mendis, S, Rickards, H, Cavanna, A, Mendis S, Rickards H, Cavanna A, Mendis, S, Rickards, H, Cavanna, A, Mendis S, Rickards H, and Cavanna A
- Abstract
Depression is the most common psychiatric disorder in patients with multiple sclerosis but the relationship between the two conditions is complex. In this article, the authors discuss the factors that may contribute to depression in patients with multiple sclerosis, the ways in which each condition may affect the other and the treatment options available.
- Published
- 2010
46. Efficacy of anti-PD-1 therapy in patients with melanoma brain metastases
- Author
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Parakh, S, Park, JJ, Mendis, S, Rai, R, Xu, W, Lo, S, Drummond, M, Rowe, C, Wong, A, McArthur, G, Haydon, A, Andrews, MC, Cebon, J, Guminski, A, Kefford, RF, Long, GV, Menzies, AM, Klein, O, Carlino, MS, Parakh, S, Park, JJ, Mendis, S, Rai, R, Xu, W, Lo, S, Drummond, M, Rowe, C, Wong, A, McArthur, G, Haydon, A, Andrews, MC, Cebon, J, Guminski, A, Kefford, RF, Long, GV, Menzies, AM, Klein, O, and Carlino, MS
- Abstract
BACKGROUND: There is limited data on the efficacy of anti-programmed death 1 (PD-1) antibodies in patients (pts) with melanoma brain metastasis (BM), particularly those which are symptomatic. METHOD: We retrospectively assessed pts with melanoma BM treated with PD-1 antibodies, nivolumab and pembrolizumab. Clinicopathologic and treatment parameters were collected and outcomes determined for intracranial (IC) response rate (RR) using a modified RECIST criteria, with up to five IC target lesions used to determine IC response, disease control rate (DCR) and progression-free survival (PFS). RESULTS: A total of 66 pts were identified with a median follow up of 7.0 months (range 0.8-24.5 months). A total of 68% were male and 45% BRAF V600 mutation positive. At PD-1 antibody commencement, 50% had an elevated LDH; 64% had local therapy to BM prior to commencing anti-PD1, of which 5% had surgical resection, 14% stereotactic radiosurgery (SRS), 18% whole-brain radiotherapy (WBRT), 27% had surgery and radiotherapy. Twenty-one per cent started anti-PD-1 as first line systemic therapy. No pt had prior anti-PD-1 treatment. The IC overall RR was 21 and DCR 56%. Responses occurred in 21% of pts with symptomatic BM. The median OS was 9.9 months (95% CI 6.93-17.74). Pts with symptomatic BM had shorter PFS than those without symptoms (2.7 vs 7.4 months, P=0.035) and numerically shorter OS (5.7 vs 13.0 months, P=0.068). Pts requiring corticosteroids also had a numerically shorter PFS (3.2 vs 7.4 months, P=0.081) and OS (4.8 vs 13.1 months, P=0.039). CONCLUSIONS: IC responses to anti-PD-1 antibodies occur in pts with BM, including those with symptomatic BM requiring corticosteroids. Prospective trials evaluating anti-PD-1 therapy in pts with BM are underway.
- Published
- 2017
47. Causes and consequences of depression in multiple sclerosis
- Author
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Mendis S, Rickards H, Cavanna A, Mendis, S, Rickards, H, and Cavanna, A
- Subjects
side effect ,hypothalamus hypophysis adrenal system ,brain region ,international classification of disease ,review ,genetic linkage ,immunopathology ,irritability ,human ,sleep disorder ,family history ,disease course ,disease association ,social psychology ,brain damage ,emotional disorder ,frontal lobe ,Expanded Disability Status Scale ,psychotherapy ,suicidal ideation ,priority journal ,multiple sclerosi ,cognitive therapy ,depression ,medical decision making ,disease severity ,diagnostic and statistical manual of mental disorder ,disease duration ,General Health Questionnaire ,disease activity ,brain atrophy ,temporal lobe - Abstract
Depression is the most common psychiatric disorder in patients with multiple sclerosis but the relationship between the two conditions is complex. In this article, the authors discuss the factors that may contribute to depression in patients with multiple sclerosis, the ways in which each condition may affect the other and the treatment options available.
- Published
- 2010
48. Efficacy of anti-PD-1 therapy in patients with melanoma brain metastases
- Author
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Park, J.J., primary, Parakh, S., additional, Mendis, S., additional, Rai, R., additional, Lo, S., additional, Haydon, A., additional, Andrews, M.C., additional, Cebon, J., additional, Guminski, A., additional, Kefford, R., additional, Long, G.V., additional, Menzies, A.M., additional, Klein, O., additional, and Carlino, M.S., additional
- Published
- 2016
- Full Text
- View/download PDF
49. Alcohol septal ablation in hypertrophic cardiomyopathy leading to permanent complete heart block; a case report
- Author
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Mendis, S. A. E. S., primary, Priyadarshan, P., additional, Seneviratne, N. H. G., additional, Ambiga, K., additional, and Herath, R. R. G. C. S. B., additional
- Published
- 2016
- Full Text
- View/download PDF
50. International Society of Hypertension (ISH): Statement on blood pressure lowering and stroke prevention
- Author
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Chalmers, J, Todd, A, Chapman, N, Bellin, L, Davis, S, Donnan, G, Frommer, M, Huxley, R, Lenfant, C, MacMahon, S, Mendis, S, Whitworth, J, Zanchetti, A., MANCIA, GIUSEPPE, Chalmers, J, Todd, A, Chapman, N, Bellin, L, Davis, S, Donnan, G, Frommer, M, Huxley, R, Lenfant, C, Macmahon, S, Mancia, G, Mendis, S, Whitworth, J, and Zanchetti, A
- Subjects
hypertension ,International Society of Hypertension ,prevention ,treatment ,MED/09 - MEDICINA INTERNA ,blood pressure lowering ,stroke - Abstract
The ISH Statement on blood pressure lowering and stroke prevention was finalized after presentation and discussion at the World Health Organization and International Society of Hypertension (WHO-ISH) Meeting on Stroke and Blood Pressure, held in Melbourne Australia, 5-7 December 2002. The meeting was conducted under the auspice of the Austin Hospital Medical Research Foundation, Melbourne.
- Published
- 2003
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