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Purpose Thyroid hormones (THs) are important mediators of brown adipose tissue (BAT) differentiation. However, the association of TH concentrations with human BAT is unclear. The present work examines the associations between circulating thyroid-stimulating hormone (TSH) and THs concentrations (i.e. free triiodothyronine, FT3, and free thyroxine, FT4), under thermoneutral (22–23°C) and cold-induced conditions, and BAT volume, 18F-fluorodeoxyglucose (18F-FDG) uptake and mean radiodensity. Methods A total of 106 young healthy, euthyroid adults (34 men/72 women; 22.0 ± 2.1 years old; 24.9 ± 4.6 kg/m2) participated in this cross-sectional study. BAT volume, 18F-FDG uptake and mean radiodensity were assessed after 2 h of personalized (i.e. contemplating each individual's shivering threshold) cold exposure via positron emission tomography/computed tomography (PET/CT) static scanning. TSH and THs levels were determined before (thermoneutral) and 1 h after the cold exposure. Results Cold exposure increased circulating FT4 (P = 0.038) and reduced TSH levels (P ≤ 0.001). Conversely, the FT3 serum concentration was not modified by cold exposure (P = 0.435). No associations were found between the TSH and THs thermoneutral (all P > 0.111) or cold-induced levels (all P > 0.067) and BAT volume, 18F-FDG uptake and mean radiodensity. These findings were independent of sex and BMI. Conclusions Thyroid function is modulated by cold exposure, yet it is not associated with BAT volume or glucose metabolism assessed after 2 h of cold exposure in young healthy, euthyroid adults.

BackgroundEmerging research supports that exercise positively affects neurodevelopment. However, the mechanisms linking exercise with brain health are largely unknown. We aimed to investigate the effect of exercise on (i) blood biomarkers selected based on previous evidence (brain-derived neurotrophic factor (BDNF), β-hydroxybutyrate (BHB), cathepsin B (CTSB), kynurenine, fibroblast growth factor 21 (FGF21), vascular cell adhesion molecule-1 (sVCAM-1)); and (ii) a panel of 92 neurology-related proteins (discovery analysis). We also investigated whether changes in these biomarkers mediate the effects of exercise on brain health (hippocampal structure and function, cognitive performance, and mental health).Methods81 children with overweight/obesity (10.1 ±1.1 years, 41% girls) were randomized to either 20-week of aerobic plus resistance exercise or control. Candidate biomarkers were assessed using ELISA for Kynurenine, FGF21, and CTSB, colorimetry for BHB, and XMap for BDNF and VCAM-1. The 92 neurology-related proteins were analyzed by antibody-based proteomic analyses.ResultsOur intervention had no significant effect on candidate biomarkers (all p>0.05). In the discovery analysis, a reduction in circulating macrophage scavenger receptor type-I (MSR1) was observed (standardized differences between groups (SMD): -0.3, p=0.001). This effect was validated using ELISA methods (SMD: -0.3, p=0.01). None of the biomarkers mediated the effects of exercise on brain health.ConclusionsOur study does not support a chronic effect of exercise on candidate biomarkers. Nevertheless, we observed that chronic exercise reduced the levels of MRS1, while it did not mediate the effects of exercise on brain health. Future studies should explore the implications of this novel biomarker on general health.HighlightsCandidate biomarkers (i.e., brain-derived neurotrophic factor (BDNF), β-hydroxybutyrate (BHB), cathepsin B (CTSB), kynurenine, fibroblast growth factor 21 (FGF21), vascular cell adhesion molecule-1 (sVCAM-1)) did not mediate the effects of exercise on brain health outcomes.Our discovery analysis, a panel of 92 neurology-related proteins, identified a reduction effect of exercise on blood-circulating MRS1.Exercise-induced changes in MRS1 did not mediate changes in brain health outcomes.The MSR1 is a membrane glycoprotein, that has not been related to exercise before, expressed in macrophages, and involved in pathological processes such as atherosclerosis, non-alcoholic fatty liver disease, and neurological diseases.Future studies should confirm the effect of exercise on MRS1 and its implications on general health.

The objective of this research is to show the production management in the construction of a multifamily building in Lima - Peru, it is worth mentioning that the main problem is that the companies do not adequately plan the optimal use of resources, the plan of attack of work, the sequence of activities through a correct design of production batch and sizing of crews, which are decisive during the execution of the work. The methodology used in this context is load and crew balancing. This allows us to manage resources and work scheduling, resulting in 100% efficiency. In conclusion, we can say that companies must maintain a correct control of their resources in order to achieve their schedules.

In rodents, exercise alters the plasma concentration of exerkines that regulate white adipose tissue (WAT) browning or brown adipose tissue (BAT) metabolism. This study aims to analyse the acute and chronic effect of exercise on the circulating concentrations of 16 of these exerkines in humans. Ten young sedentary adults (6 female) performed a maximum walking effort test and a resistance exercise session. The plasma concentration of 16 exerkines was assessed before, and 3, 30, 60, and 120 min after exercise. Those exerkines modified by exercise were additionally measured in another 28 subjects (22 women). We also measured the plasma concentrations of the exerkines before and after a 24-week exercise programme (endurance + resistance; 3-groups: control, moderate-intensity and vigorous-intensity) in 110 subjects (75 women). Endurance exercise acutely increased the plasma concentration of lactate, norepinephrine, brain-derived neurotrophic factor, interleukin 6, and follistatin-like protein 1 (3 min after exercise), and musclin and fibroblast growth factor 21 (30 and 60 min after exercise), decreasing the plasma concentration of leptin (30 min after exercise). Adiponectin, atrial natriuretic peptide (ANP), beta-aminoisobutyric acid, meteorin-like, follistatin, pro-ANP, irisin and myostatin were not modified or not detectable. The resistance exercise session increased the plasma concentration of lactate 3 min after exercise. Chronic exercise did not alter the plasma concentration of these exerkines. In sedentary young adults, acute endurance exercise releases to the bloodstream exerkines that regulate BAT metabolism and WAT browning. In contrast, neither a low-volume resistance exercise session nor a 24-week training programme modified plasma levels of these molecules.

This research work has a great influence on the physical security of the urban infrastructure and the citizens of our capital city, that is why it is necessary to apply prevention strategies since our city is located in a very vulnerable area to seismic events, mainly huaycos, floods and landslides, settlements, landslides and other superficial mass movements, so it is necessary to have knowledge of the causes and effects of these phenomena, the different types and carrying capacity of soils in the districts of Metropolitan Lima, in order to contribute to the knowledge of the degree of vulnerability in which urban areas, marginal urban areas, human settlements are exposed. In conclusion, surveys of public servants allowed us to determine that only 55% of them know the meaning of risk and vulnerability, so 45% are totally unaware of these terms. Likewise, surveys of the general public on the lack of a prevention culture, 83% indicated that they did, hence the need to apply a course or training on disaster risk management issues at all educational levels.

This work was supported by the Fundacion Alfonso Martin Escudero (to B.M.T), by the Dutch Heart Foundation (2017T016 to S.K.), by the Dutch Society for Diabetes Research (NVDO; Prof. dr. J. Terpstra Award to S.K.), the Dutch Diabetes Foundation (2015.81.1808 to M.R.B.) and the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation (CVON2014-02 ENERGISE and CVON2017 GENIUS-2 to P.C.N.R.), Context: Cold exposure mobilizes lipids to feed thermogenic processes in organs, including brown adipose tissue (BAT). In rodents, BAT metabolic activity exhibits a diurnal rhythm, which is highest at the start of the wakeful period. Objective: We investigated whether cold-induced thermogenesis displays diurnal variation in humans and differs between the sexes. Methods: This randomized crossover study included 24 young and lean male (n = 12) and female (n = 12) participants who underwent 2.5-hour personalized cooling using water-perfused mattresses in the morning (7:45 am) and evening (7:45 pm), with 1 day in between. We measured energy expenditure (EE) and supraclavicular skin temperature in response to cold exposure. Results: In males, cold-induced EE was higher in the morning than in the evening (+54% ± 10% vs +30% ± 7%; P = 0.05) but did not differ between morning and evening in females (+37% ± 9% vs +30% ± 10%; P = 0.42). Only in males, supraclavicular skin temperature upon cold increased more in morning than evening (+0.2 ± 0.1 °C vs −0.2 ± 0.2 °C; P = 0.05). In males, circulating free fatty acid (FFA) levels were increased after morning cold exposure, but not evening (+90% ± 18% vs +9% ± 8%; P < 0.001). In females, circulating FFA (+94% ± 21% vs +20% ± 5%; P = 0.006), but also triglycerides (+42% ± 5% vs +29% ± 4%, P = 0.01) and cholesterol levels (+17% ± 2% vs 11% ± 2%; P = 0.05) were more increased after cold exposure in morning than in evening. Conclusion: Cold-induced thermogenesis is higher in morning than evening in males; however, lipid metabolism is more modulated in the morning than the evening in females., Fundacion Alfonso Martin Escudero, Netherlands Heart Foundation 2017T016 CVON2014-02 ENERGISE CVON2017 GENIUS-2, Dutch Society for Diabetes Research (NVDO), Dutch Diabetes Foundation 2015.81.1808, Netherlands Cardiovascular Research Initiative

Objectives Brown adipose tissue (BAT) is important in the maintenance of cardiometabolic health in rodents. Recent reports appear to suggest the same in humans, although if this is true remains elusive partly because of the methodological bias that affected previous research. This cross-sectional work reports the relationships of cold-induced BAT volume, activity (peak standardized uptake, SUVpeak), and mean radiodensity (an inverse proxy of the triacylglycerols content) with the cardiometabolic and inflammatory profile of 131 young adults, and how these relationships are influenced by sex and body weight. Design This is a cross-sectional study. Methods Subjects underwent personalized cold exposure for 2 h to activate BAT, followed by static 18F-fluorodeoxyglucose PET-CT scanning to determine BAT variables. Information on cardiometabolic risk (CMR) and inflammatory markers was gathered, and a CMR score and fatty liver index (FLI) were calculated. Results In men, BAT volume was positively related to homocysteine and liver damage markers concentrations (independently of BMI and seasonality) and the FLI (all P ≤ 0.05). In men, BAT mean radiodensity was negatively related to the glucose and insulin concentrations, alanine aminotransferase activity, insulin resistance, total cholesterol/HDL-C, LDL-C/HDL-C, the CMR score, and the FLI (all P ≤ 0.02). In women, it was only negatively related to the FLI (P < 0.001). These associations were driven by the results for the overweight and obese subjects. No relationship was seen between BAT and inflammatory markers (P > 0.05). Conclusions A larger BAT volume and a lower BAT mean radiodensity are related to a higher CMR, especially in young men, which may support that BAT acts as a compensatory organ in states of metabolic disruption.

El objetivo general de este estudio es determinar la Influencia del programa de fortalecimiento en la expresión oral en estudiantes de la I.E. N° 347 de Lima, 2021. El estudio fue de tipo aplicada y de diseño pre experimental con pre test y pos test aplicado al grupo experimental, se consideró como población a estudiantes de 5 años del nivel inicial, el muestreo fue no probabilístico, pues se incluyó a aquellos estudiantes que facilitaron la aplicación del programa, siendo la muestra de 14 estudiantes. Se empleó la técnica de la encuesta y como instrumento el cuestionario. Los resultados de la investigación muestran que existe un nivel de significancia de =0,001 donde p

The objective of the research is to design and apply the Ecotourism Microzoning model proposed through GIS for the development of ecotourism in the Marco district, which is located in the central and western part of the Yanamarca Valley, in the province of Jauja. The study was carried out from 2019 to April 2021, the elaboration had three fundamental processes: a) Preparation of the process carried out in the city of Lima, generating a frame of reference that would guide the rest of the development of the work; b) A field stage that involved travel, a strong component of consultation with institutions, local populations; and c) A stage of elaboration of the final product. As a result, well-marked areas were determined: Very high level of 0.467 of value, which represents 10% of tourist use, to preserve, maintain the ecosystem and cultural attractions; high level, of 0.265 value, which represents 5% with potential that can reach a very high level. In conclusion, the elaboration of the cartography, allowed the identification of the tourist resources, interrelate the parameters and descriptors that allows at the same time to order the tourist activities. That later a web mapping was designed "Ecotourism Microzoning of the Marco district" that will facilitate the dissemination of the tourist potential of the Marco district, since this will allow to implement the proposals and improve them for the satisfaction of tourists. In addition, it will be a very useful tool in municipal management for the development of orderly and decentralized tourism. La investigación tiene como objetivo diseñar y aplicar el modelo de microzonificación ecoturístico propuesto mediante SIG para el desarrollodel ecoturismo en el distrito de Marco que está ubicado en la parte centraly occidental del Valle de Yanamarca, en la provincia de Jauja. El estudio se realizó desde el año 2019 hasta abril del 2021, la elaboración tuvo tres procesos fundamentales: a) Preparación del proceso llevado a cabo en la ciudad Lima,generando un marco de referencia que guiaría el resto de desarrollo del trabajo; b) Una etapa de campo que involucro viajes, un fuerte componente de consulta con instituciones, poblaciones locales; y c) Una etapa de elaboración del producto final. Como resultado se determinaron zonas bien marcadas: Nivel muy alto de 0.467 de valor, que representa el 10% de uso turístico, depreservar, mantener el ecosistema y los atractivos culturales; nivel alto, de 0.265 valor, que representa el 5% con potencial que puede alcanzar un nivel muy alto. En conclusión, la elaboración de la cartografía, permitió laidentificación de los recursos turísticos, interrelacionar los parámetros y descriptores que permite a la vez ordenar las actividades turísticas. Que posteriormente se diseñó un web mapping “Microzonificación Ecoturísticodel distrito de Marco” que facilitará la difusión del potencial turístico del distrito de Marco, ya que esto permitirá implementar las propuestas y mejorarlas para la satisfacción de los turistas. Además, será una herramientamuy útil en la gestión municipal para el desarrollo de un turismo ordenado y descentralizado.

La investigación tiene como objetivo diseñar y aplicar el modelo de microzonificación ecoturístico propuesto mediante SIG para el desarrollodel ecoturismo en el distrito de Marco que está ubicado en la parte centraly occidental del Valle de Yanamarca, en la provincia de Jauja. El estudio se realizó desde el año 2019 hasta abril del 2021, la elaboración tuvo tres procesos fundamentales: a) Preparación del proceso llevado a cabo en la ciudad Lima,generando un marco de referencia que guiaría el resto de desarrollo del trabajo; b) Una etapa de campo que involucro viajes, un fuerte componente de consulta con instituciones, poblaciones locales; y c) Una etapa de elaboración del producto final. Como resultado se determinaron zonas bien marcadas: Nivel muy alto de 0.467 de valor, que representa el 10% de uso turístico, depreservar, mantener el ecosistema y los atractivos culturales; nivel alto, de 0.265 valor, que representa el 5% con potencial que puede alcanzar un nivel muy alto. En conclusión, la elaboración de la cartografía, permitió laidentificación de los recursos turísticos, interrelacionar los parámetros y descriptores que permite a la vez ordenar las actividades turísticas. Que posteriormente se diseñó un web mapping “Microzonificación Ecoturísticodel distrito de Marco” que facilitará la difusión del potencial turístico del distrito de Marco, ya que esto permitirá implementar las propuestas y mejorarlas para la satisfacción de los turistas. Además, será una herramientamuy útil en la gestión municipal para el desarrollo de un turismo ordenado y descentralizado.

In 2020, A Major Offshore Operating Company in UAE faced a high differential pressure stuck event. This took place, during the execution of formation evaluation with a conveyed pipe sampling BHA. It is well known that after a differentially stuck pipe event happens, the success ratio will be time dependent (i.e. the less time a pipe remains stuck, the more chances there will be for it to become released) and the chances of releasing the BHA are always limited to the logging tools tensile limitations. One of the most common and successful methods to release differentially stuck BHA's specifically in limestone formations is by pumping and soaking acid pills. However, under such a high differential pressure environment, the use of acid may induce losses in the so called "thief zones", causing worse problems. The standard release procedure started by working the string within the tensile limits, followed by pumping acid pills (using the available volume mobilized before spudding each drilling section). During the first acid pills pumped to attempt to release the stuck pipe, loss volume pump rates, acid pill position(s) and coverage in the annulus was assessed and evaluated. Based on the results it was observed that the thief zone was in direct contact with the Pipe Conveyed circulation port, at the latching assembly. This then created a situation whereby, the acid pills were lost immediately after the acid came into contact with the formation. Utilizing low acid concentration pills also had the same effect. The solution was to pump an Obturating pill made-up of a weighting agent as a spacer behind the high volume, low concentration acid pill with crosslinking divergent chemicals, pumped at a high flow rate. This solution reduced the acid losses across the thief zone and once the Obturating pill came into contact with the loss zone, it facilitated the seal and cured the losses, by allowing the acid to move up the annulus until it reached the differentially stuck point and soaked across the problematic area. Once the acid pill was successfully placed at the required location using this method, the string was worked and successfully released. This combination of low concentration acid along with crosslinking divergent chemicals coupled with the Obturating pill behind the acid helped a major offshore operating company to pump the acid pill under partial losses only, to regain full circulation after only 10 bbl. of Obturating pill had entered inside the annulus. It allowed the acid pill to react across the stuck point, while keeping the string under low torque and compression. The operator was able to release the sampling BHA and bring it back to surface avoiding a lost in hole cost of around 4 MM$. The Obturating pill combined with low concentration CDC acid pill is proven to be a successful method in drilling operations when trying to release differentially stuck BHA's within a wellbore.

Purpose: Thyroid hormones (THs) are important mediators of brown adipose tissue (BAT) differentiation. However, the association of TH concentrations with human BAT is unclear. The present work examines the associations between circulating thyroid-stimulating hormone (TSH) and THs concentrations (i.e. free triiodothyronine, FT3, and free thyroxine, FT4), under thermoneutral (22-23 degrees C) and cold-induced conditions, and BAT volume, F-18-fluorodeoxyglucose (F-18-FDG) uptake and mean radiodensity.Methods: A total of 106 young healthy, euthyroid adults (34 men/72 women; 22.0 +/- 2.1 years old; 24.9 +/- 4.6 kg/m(2)) participated in this cross-sectional study. BAT volume, F-18-FDG uptake and mean radiodensity were assessed after 2 h of personalized (i.e. contemplating each individual's shivering threshold) cold exposure via positron emission tomography/computed tomography (PET/CT) static scanning. TSH and THs levels were determined before (thermoneutral) and 1 h after the cold exposure.Results: Cold exposure increased circulating FT4 (P = 0.038) and reduced TSH levels (P 0.111) or cold-induced levels (all P > 0.067) and BAT volume, F-18-FDG uptake and mean radiodensity. These findings were independent of sex and BMI.Conclusions: Thyroid function is modulated by cold exposure, yet it is not associated with BAT volume or glucose metabolism assessed after 2 h of cold exposure in young healthy, euthyroid adults.

A Major Operating Company in UAE planned and drilled a challenging 6 inch horizontal drain after crossing twenty-seven formation sub-layers. The heterogeneity of pore pressure varied from equivalent mud weights as high as 10.6 ppg to as low as 7.1 ppg across the exposed reservoirs. Control of the equivalent circulating density (ECD) values to safely drill across these multi-reservoir sections and diverse reservoir pressures was one of the top challenges on this well, as the fracture gradients (FG) ranged from 13.5 ppg across the competent reservoirs to as low as 11ppg across the fractured reservoir section. The offset well data review show that 4 out of 6 wells encountered moderate, severe and total losses with mud weight (MW) ranging from 11 ppg to 11.3 ppg, which were cured by using heavy LCM treatments and in some cases, after several failed attempts to cure losses, cement plugs were used. Historically, the average time spent curing total losses in these wells varied from 2-3.5 weeks causing well cost increments as consequence of this non-productive time. All of the above, without mentioning the extra efforts, resources and risks were faced due to well control and stuck pipe events which occurred on those wells. Engineering and Operation teams worked together to engineer a solution to drill this well in one run while safely maintaining the well under control and managing the losses. The Bottom Hole Assembly (BHA) was designed to withstand the well challenges including multiple contingency options. These options allowed:Improving hole quality while tripping using a special type of eccentric reamer stabilizer.Pumping various LCM concentration scenarios through a multi-cycle circulation valve. In addition, a special type of float valve was placed on the top of the BHA as barrier, stopping back flow under surface backpressure or kick scenarios.Optimizing mud weight by using formation pressure while drilling (FPWD) and monitoring both equivalent circulating density ECD and equivalent static density (ESD) by pressure while drilling tools. The drilling fluid was loaded with non-damaging loss circulation material without compromising the MWD/LWD limits. Additionally, the mud rheology was carefully selected and monitored to achieve the desired ECD. On surface, a managed pressure while drilling system was deployed to give control on reservoir pressures. In instances of influx, MPD allows to early detect any kick and controlled by surface back pressure without requiring shut in for applying standard well control techniques. Keeping the well under control by surface back pressure (SBP) during connections time (flow–off). Additionally, MPD also enables the contingency of applying pressurized mud capping in case of unable to control the losses. As decision point, a loss management plan was prepared and implemented. Also, a dynamic formation integrity test was planned and performed to calibrate the fracture gradient across the loss zones. The problematic zone was successfully drilled with one BHA in under six days (5.73 days). The estimated savings for the company were 8 days, which equates to ±1MMUS$ after including the MPD cost which increased the well cost by 200MUS$. To further complement the outright savings, the engineered solution managed to safely stave off operational complications as well as incurring the related complexities and non-productive time (NPT) as recorded on the offset wells. Additionally, well was successfully landed and geo-steered across the target formation and 4½ in liner was run and cemented off-bottom avoiding the need to develop a slot recovery scope on this well with an extra duration of +/-35 days. The engineered solution provided a high level of preparation and contingencies within the BHA, Managed Pressure Drilling Equipment, real time monitoring, mud and cement formulation. The applied techniques allowed the operating company to successfully execute this challenge well within the proposed time and budget.

Drilling horizontal wells in the mature giant carbonate fields offshore Abu Dhabi, where high uncertainty regarding the lateral distribution of fluids results in variable water saturation, is very challenging. In order to meet the challenges and reduce uncertainty, the plan was to drill pilot holes to evaluate the resistivity of the target zones and plan horizontal sections based on the information gained. To investigate the possibility of avoiding pilot holes in the future, an ultra-deep electromagnetic (EM) tool was deployed to map the mature reservoirs, identifying formation and fluid boundaries before penetrating them, avoiding the need for pilot holes. Prewell inversion modeling was conducted to optimize the spacing and firing frequency selection and to facilitate early real-time geosteering and geostopping decisions. The plan was to run the ultra-deep resistivity mapping tool in conjunction with shallow propagation resistivity, density, and neutron porosity while drilling the 8 ½-in. landing section. The real-time ultra-deep EM inversion was run using depth of inversions up to 120 ft., to be able to detect the reservoir early and evaluate the predicted reservoir resistivity. This would allow optimization of any geostopping decision. The ultra-deep EM tool delivered accurate mapping of thin reservoir layers while drilling the 8 ½ inch section, as well as enhanced mapping of low resistivity zones up to 85 ft. True Vertical Thickness (TVT) in a challenging low resistivity environment. The real-time EM inversion enabled the prediction of resistivity values in target zones prior to entering the reservoir; values were later crosschecked against open-hole logs for validation. The results enabled identification of the optimal geostopping point in the 8 ½-in. section, enabling up to seven rig days to be saved in the future by eliminating pilot holes, in addition to eliminating the risk of setting a whipstock at high inclination with subsequent milling operations. In specific cases, this minimizes drilling risks in unknown/high reservoir pressure zones by improving early detection of a formation tops, thus improving geostopping decisions. Plans were modified for a nearby future well and the pilot-hole phase was eliminated because of the confidence provided by these results. Deployment of the ultra-deep EM tool in these mature carbonate reservoirs may reduce the uncertainty associated with fluid migration. In addition, use of the tool can facilitate precise geosteering to maintain distance from fluid boundaries in thick reservoirs. Furthermore, due to the depths of investigation possible with these tools, it will help enable the mapping of nearby reservoirs for future development. Further multi-disciplinary studies remain desirable using existing standard log data to validate the effectiveness of this concept for different fields and reservoirs.

Extracellular matrix (ECM) remodeling plays important roles in both white adipose tissue (WAT) and the skeletal muscle (SM) metabolism. Excessive adipocyte hypertrophy causes fibrosis, inflammation, and metabolic dysfunction in adipose tissue, as well as impaired adipogenesis. Similarly, disturbed ECM remodeling in SM has metabolic consequences such as decreased insulin sensitivity. Most of described ECM molecular alterations have been associated with DNA sequence variation, alterations in gene expression patterns, and epigenetic modifications. Among others, the most important epigenetic mechanism by which cells are able to modulate their gene expression is DNA methylation. Epigenome-Wide Association Studies (EWAS) have become a powerful approach to identify DNA methylation variation associated with biological traits in humans. Likewise, Genome-Wide Association Studies (GWAS) and gene expression microarrays have allowed the study of whole-genome genetics and transcriptomics patterns in obesity and metabolic diseases. The aim of this review is to explore the molecular basis of ECM in WAT and SM remodeling in obesity and the consequences of metabolic complications. For that purpose, we reviewed scientific literature including all omics approaches reporting genetic, epigenetic, and transcriptomic (GWAS, EWAS, and RNA-seq or cDNA arrays) ECM-related alterations in WAT and SM as associated with metabolic dysfunction and obesity. Yes