17 results on '"Mendez, C. D."'
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2. Single Trial P300 Detection Using Dimensionality Reduction and Extreme Learning Machine
- Author
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Blanco-Díaz, C. F., Guerrero-Mendez, C. D., Bastos-Filho, T. F., Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Marques, Jefferson Luiz Brum, editor, Rodrigues, Cesar Ramos, editor, Suzuki, Daniela Ota Hisayasu, editor, Marino Neto, José, editor, and García Ojeda, Renato, editor
- Published
- 2024
- Full Text
- View/download PDF
3. Wavelet Coherence Corticomuscular Analysis During Tasks Involved in Object Manipulation
- Author
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Guerrero-Mendez, C. D., Blanco-Diaz, C. F., Bastos-Filho, T. F., Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Marques, Jefferson Luiz Brum, editor, Rodrigues, Cesar Ramos, editor, Suzuki, Daniela Ota Hisayasu, editor, Marino Neto, José, editor, and García Ojeda, Renato, editor
- Published
- 2024
- Full Text
- View/download PDF
4. Author Correction: Proton acceleration in thermonuclear nova explosions revealed by gamma rays (Nature Astronomy, (2022), 6, 6, (689-697), 10.1038/s41550-022-01640-z)
- Author
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Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. A., Artero, M., Asano, K., Baack, D., Babic, A., Baquero, A., de Almeida, U. B., Barrio, J. A., Batkovic, I., Gonzalez, J. B., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bokenkamp, H., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. D., Depaoli, D., Di Pierro, F., Di Venere, L., Espineira, E. D. S., Prester, D. D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. F., Alonso, L. F., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., Lopez, R. J. G., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Ishio, K., Iwamura, Y., Martinez, I. J., Jormanainen, J., Jouvin, L., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., Lopez-Coto, R., Lopez-Moya, M., Lopez-Oramas, A., Loporchio, S., de Oliveira Fraga, B. M., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Aguilar, A. M., Mazin, D., Menchiari, S., Mender, S., Micanovic, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Rosillo, M. N., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletic, L., Penil, P., Persic, M., Pihet, M., Moroni, P. G. P., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Spolon, A., Stamerra, A., Striskovic, J., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Acosta, M. V., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zaric, D., Ambrosino, F., Cecconi, M., Catanzaro, G., Ferrara, C., Frasca, A., Munari, M., Giustolisi, L., Alonso-Santiago, J., Giarrusso, M., Munari, U., and Valisa, P.
- Published
- 2022
5. Discovery of very high Energy $\gamma$ -ray Emission from the Blazar 1ES 0033+595 by the MAGIC Telescopes
- Author
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Aleksi, J., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Bangale, P., De Almeida, U. B., Barrio, J. A., Gonzalez, J. B., Bednarek, W., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Fidalgo, D. C., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., Mendez, C. D., Doert, M., Dominguez, A., Prester, D. D., Dorner, D., Doro, M., Einecke, S., Eisenacher, D., Elsaesser, D., Farina, E., Ferenc, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Lopez, R. J. G., Garczarczyk, M., Terrats, D. G., Gaug, M., Godinovi, N., Munoz, A. G., Gozzini, S. R., Hadasch, D., Hayashida, M., Herrera, J., Herrero, A., Hildebrand, D., Hose, J., Hrupec, D., Idec, W., Kadenius, V., Kellermann, H., Kodani, K., Konno, Y., Krause, J., Kubo, H., Kushida, J., Barbera, A. L., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martinez, M., Mazin, D., Menzel, U., Meucci, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Munar-Adrover, P., Nakajima, D., Niedzwiecki, A., Nilsson, K., Nishijima, K., Noda, K., Nowak, N., Orito, R., Overkemping, A., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes-Fortuny, X., Partini, S., Persic, M., Prada, F., Moroni, P. G. P., Prandini, E., Preziuso, S., Puljak, I., Reinthal, R., Rhode, W., Ribo, M., Rico, J., Garcia, J. R., Rugamer, S., Saggion, A., Saito, T., Saito, K., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shore, S. N., Sillanpaa, A., Sitarek, J., Snidaric, I., Sobczynska, D., Spanier, F., Stamatescu, V., Stamerra, A., Steinbring, T., Storz, J., Sun, S., Suri, T., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzi, T., Tescaro, D., Teshima, M., Thaele, J., Tibolla, O., Torres, D. F., Toyama, T., Treves, A., Uellenbeck, M., Vogler, P., Wagner, R. M., Zandanel, F., Zanin, R., Collaboration), (MAGIC, Tronconi, V., Buson, S., and Borghese, A.
- Abstract
Monthly notices of the Royal Astronomical Society 446(1), 217 - 225 (2015). doi:10.1093/mnras/stu2024, Published by Oxford Univ. Press, Oxford
- Published
- 2015
- Full Text
- View/download PDF
6. Observations of the magnetars 4U 0142+61 and 1E 2259+586 with the MAGIC telescopes (Research Note)
- Author
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Aleksic, J., Antonelli, L. A., Antoranz, P., Asensio, M., U. B., De, Barrio, J. A., Gonzalez, J. B., Bednarek, W., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Boller, A., Bonnoli, G., Tridon, D. B., Bretz, T., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Cossio, L., Covino, S., Vela, P. D., Dazzi, F., Angelis, A. D., Caneva, G. D., Del, E. D., Lotto, B. D., Mendez, C. D., Ortega, A. D., Doert, M., Prester, D. D., Dorner, D., Doro, M., Eisenacher, D., Elsaesser, D., Ferenc, D., Fonseca, M. V., Font, L., Fruck, C., R. J. G., Garczarczyk, M., Terrats, D. G., Gaug, M., Giavitto, G., Godinovic, N., Munoz, A. G., Gozzini, S. R., Hadamek, A., Hadasch, D., Hafner, D., Herrero, A., Hose, J., Hrupec, D., Huber, B., Jankowski, F., Jogler, T., Kadenius, V., Klepser, S., Knoetig, M. L., Krahenbuhl, T., Krause, J., Kushida, J., Barbera, A. L., Lelas, D., Leonardo, E., Lewandowska, N., Lindfors, E., Lombardi, S., Lopez, M., Lopez Coto, R., Lopez Oramas, A., Lorenz, E., Makariev, M., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martinez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Moldon, J., Moralejo, A., Munar Adrover, P., Niedzwiecki, A., Nieto, D., Nilsson, K., Nowak, N., Orito, R., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Partini, S., Persic, M., Pilia, M., Pochon, J., Prada, F., PRADA MORONI, PIER GIORGIO, Prandini, E., Puljak, I., Reichardt, I., Reinthal, R., Rhode, W., Ribo, M., Rico, J., Rugamer, S., Saggion, A., Saito, K., Saito, T. Y., Salvati, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shore, STEVEN NEIL, Sillanpaa, A., Sitarek, J., Snidaric, I., Sobczynska, D., Spanier, F., Spiro, S., Stamatescu, V., Stamerra, A., Steinke, B., Storz, J., Sun, S., Suric, T., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Tibolla, O., Torres, D. F., Toyama, T., Treves, A., Uellenbeck, M., Vogler, P., Wagner, R. M., Weitzel, Q., Zabalza, V., Zandanel, F., Zanin, R., Rea, N., and Backes, M.
- Subjects
X-RAY PULSAR ,MAGNETIZED NEUTRON-STARS ,SOFT GAMMA-REPEATERS ,2002 OUTBURST ,CRAB-NEBULA ,EMISSION ,4U-0142+61 ,RXTE ,DISCOVERY ,BURSTS - Published
- 2013
7. PERIODIC VERY HIGH ENERGY gamma-RAY EMISSION FROM LS I+61 degrees 303 OBSERVED WITH THE MAGIC TELESCOPE
- Author
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Albert, J., Aliu, E., Anderhub, H., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Barrio, J. A., Bartko, H., Bastieri, D., Becker, J. K., Bednarek, W., Berger, K., Bernardini, E., Bigongiari, C., Biland, A., Bock, R. K., Bonnoli, G., Bordas, P., Bosch Ramon, V., Bretz, T., Britvitch, I., Camara, M., Carmona, E., Chilingarian, A., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Curtef, V., Dazzi, F., Angelis, A. D., del Pozo, E. D., los Reyes, R. d., Lotto, B. D., Maria, M. D., Sabata, F. D., Mendez, C. D., Dominguez, A., Dorner, D., Doro, M., Errando, M., Fagiolini, M., Ferenc, D., Fernandez, E., Firpo, R., Fonseca, M. V., Font, L., Galante, N., Lopez, R. J. G., Garczarczyk, M., Gaug, M., Goebel, F., Hayashida, M., Herrero, A., Hohne, D., Hose, J., Hsu, C. C., Huber, S., Jogler, T., Kranich, D., Barbera, A. L., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, Francesco, Lopez, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Meucci, M., Meyer, M., Miranda, J. M., Mirzoyan, R., Mizobuchi, S., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Otte, N., Oya, I., Panniello, M., Paoletti, R., Paredes, J. M., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez Torres, M. A., Persic, M., Peruzzo, L., Piccioli, A., Prada, F., Prandini, E., Puchades, N., Raymers, A., Rhode, W., Ribo, M., Rico, J., Rissi, M., Robert, A., Rugamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sanchez Conde, M., Sartori, P., Satalecka, K., Scalzotto, V., Scapin, V., Schmitt, R., Schweizer, T., Shayduk, M., Shinozaki, K., Shore, S. N., Sidro, N., Sierpowska Bartosik, A., Sillanpaa, A., Sobczynska, D., Spanier, F., Stamerra, A., Stark, L. S., Takalo, L., Tavecchio, F., Temnikov, P., Tescaro, D., Teshima, M., Tluczykont, M., Torres, D. F., Turini, N., Vankov, H., Venturini, A., Vitale, V., Wagner, R. M., Wittek, W., Zabalza, V., Zandanel, F., Zanin, R., Zapatero, J., J., Albert, E., Aliu, H., Anderhub, L. A., Antonelli, P., Antoranz, M., Backe, C., Baixera, J. A., Barrio, H., Bartko, D., Bastieri, J. K., Becker, W., Bednarek, K., Berger, E., Bernardini, C., Bigongiari, A., Biland, R. K., Bock, G., Bonnoli, P., Borda, V., Bosch Ramon, T., Bretz, I., Britvitch, M., Camara, E., Carmona, A., Chilingarian, S., Commichau, J. L., Contrera, J., Cortina, M. T., Costado, S., Covino, V., Curtef, F., Dazzi, A. D., Angeli, E. D., del Pozo, R. d., los Reye, B. D., Lotto, M. D., Maria, F. D., Sabata, C. D., Mendez, A., Dominguez, D., Dorner, M., Doro, M., Errando, M., Fagiolini, D., Ferenc, E., Fernandez, R., Firpo, M. V., Fonseca, L., Font, N., Galante, R. J. G., Lopez, M., Garczarczyk, M., Gaug, F., Goebel, M., Hayashida, A., Herrero, D., Hohne, J., Hose, C. C., Hsu, S., Huber, T., Jogler, D., Kranich, A. L., Barbera, A., Laille, E., Leonardo, E., Lindfor, S., Lombardi, Longo, Francesco, M., Lopez, E., Lorenz, P., Majumdar, G., Maneva, N., Mankuzhiyil, K., Mannheim, L., Maraschi, M., Mariotti, M., Martinez, D., Mazin, M., Meucci, M., Meyer, J. M., Miranda, R., Mirzoyan, S., Mizobuchi, M., Mole, A., Moralejo, D., Nieto, K., Nilsson, J., Ninkovic, N., Otte, I., Oya, M., Panniello, R., Paoletti, J. M., Parede, M., Pasanen, D., Pascoli, F., Pau, R. G., Pegna, M. A., Perez Torre, M., Persic, L., Peruzzo, A., Piccioli, F., Prada, E., Prandini, N., Puchade, A., Raymer, W., Rhode, M., Ribo, J., Rico, M., Rissi, A., Robert, S., Rugamer, A., Saggion, T. Y., Saito, M., Salvati, M., Sanchez Conde, P., Sartori, K., Satalecka, V., Scalzotto, V., Scapin, R., Schmitt, T., Schweizer, M., Shayduk, K., Shinozaki, S. N., Shore, N., Sidro, A., Sierpowska Bartosik, A., Sillanpaa, D., Sobczynska, F., Spanier, A., Stamerra, L. S., Stark, L., Takalo, F., Tavecchio, P., Temnikov, D., Tescaro, M., Teshima, M., Tluczykont, D. F., Torre, N., Turini, H., Vankov, A., Venturini, V., Vitale, R. M., Wagner, W., Wittek, V., Zabalza, F., Zandanel, R., Zanin, and J., Zapatero
- Subjects
Very High Energy Gamma-ray Astronomy ,MAGIC telescope ,Gamma-ray Binaries ,gamma ray astronomy ,Cosmic rays ,IMAGING CHERENKOV DETECTOR - Abstract
The MAGIC collaboration has recently reported the discovery of gamma-ray emission from the binary system LS I +61 degrees 303 in the TeV energy region. Here we present new observational results on this source in the energy range between 300 GeV and 3 TeV. In total, 112 hr of data were taken between 2006 September and December covering four orbital cycles of this object. This large amount of data allowed us to produce an integral flux light curve covering for the first time all orbital phases of LS I +61 degrees 303. In addition, we also obtained a differential energy spectrum for two orbital phase bins covering the phase range 0.5 < phi < 0.6 and 0.6 < phi < 0.7. The photon index in the two phase bins is consistent within the errors with an average index Gamma = 2.6 +/- 0.2(stat) +/- 0.2(sys). LS I +61 degrees 303 was found to be variable at TeV energies on timescales of days. These new MAGIC measurements allowed us to search for intranight variability of the very high energy emission; however, no evidence for flux variability on timescales down to 30 min was found. To test for possible periodic structures in the light curve, we apply the formalism developed by Lomb and Scargle to the LS I +61 degrees 303 data taken in 2005 and 2006. We found the LS I +61 degrees 303 data set to be periodic with a period of (26.8 +/- 0.2) days (with a post-trial chance probability of 10(-7)), close to the orbital period.
- Published
- 2009
8. Search for very high energy gamma-rays from the z = 0.896 quasar 4C +55.17 with the MAGIC telescopes
- Author
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Aleksi , J., primary, Ansoldi, S., additional, Antonelli, L. A., additional, Antoranz, P., additional, Babic, A., additional, Bangale, P., additional, de Almeida, U. B., additional, Barrio, J. A., additional, Gonzalez, J. B., additional, Bednarek, W., additional, Berger, K., additional, Bernardini, E., additional, Biland, A., additional, Blanch, O., additional, Bock, R. K., additional, Bonnefoy, S., additional, Bonnoli, G., additional, Borracci, F., additional, Bretz, T., additional, Carmona, E., additional, Carosi, A., additional, Fidalgo, D. C., additional, Colin, P., additional, Colombo, E., additional, Contreras, J. L., additional, Cortina, J., additional, Covino, S., additional, Da Vela, P., additional, Dazzi, F., additional, De Angelis, A., additional, De Caneva, G., additional, De Lotto, B., additional, Mendez, C. D., additional, Doert, M., additional, Dominguez, A., additional, Prester, D. D., additional, Dorner, D., additional, Doro, M., additional, Einecke, S., additional, Eisenacher, D., additional, Elsaesser, D., additional, Farina, E., additional, Ferenc, D., additional, Fonseca, M. V., additional, Font, L., additional, Frantzen, K., additional, Fruck, C., additional, Lopez, R. J. G., additional, Garczarczyk, M., additional, Terrats, D. G., additional, Gaug, M., additional, Giavitto, G., additional, Godinovi , N., additional, Munoz, A. G., additional, Gozzini, S. R., additional, Hadasch, D., additional, Hayashida, M., additional, Herrero, A., additional, Hildebrand, D., additional, Hose, J., additional, Hrupec, D., additional, Idec, W., additional, Kadenius, V., additional, Kellermann, H., additional, Knoetig, M. L., additional, Kodani, K., additional, Konno, Y., additional, Krause, J., additional, Kubo, H., additional, Kushida, J., additional, Barbera, A. L., additional, Lelas, D., additional, Lewandowska, N., additional, Lindfors, E., additional, Lombardi, S., additional, Lopez, M., additional, Lopez-Coto, R., additional, Lopez-Oramas, A., additional, Lorenz, E., additional, Lozano, I., additional, Makariev, M., additional, Mallot, K., additional, Maneva, G., additional, Mankuzhiyil, N., additional, Mannheim, K., additional, Maraschi, L., additional, Marcote, B., additional, Mariotti, M., additional, Martinez, M., additional, Mazin, D., additional, Menzel, U., additional, Meucci, M., additional, Miranda, J. M., additional, Mirzoyan, R., additional, Moralejo, A., additional, Munar-Adrover, P., additional, Nakajima, D., additional, Niedzwiecki, A., additional, Nilsson, K., additional, Nishijima, K., additional, Nowak, N., additional, Orito, R., additional, Overkemping, A., additional, Paiano, S., additional, Palatiello, M., additional, Paneque, D., additional, Paoletti, R., additional, Paredes, J. M., additional, Paredes-Fortuny, X., additional, Partini, S., additional, Persic, M., additional, Prada, F., additional, Moroni, P. G. P., additional, Prandini, E., additional, Preziuso, S., additional, Puljak, I., additional, Reinthal, R., additional, Rhode, W., additional, Ribo, M., additional, Rico, J., additional, Garcia, J. R., additional, Rugamer, S., additional, Saggion, A., additional, Saito, T., additional, Saito, K., additional, Salvati, M., additional, Satalecka, K., additional, Scalzotto, V., additional, Scapin, V., additional, Schultz, C., additional, Schweizer, T., additional, Shore, S. N., additional, Sillanpaa, A., additional, Sitarek, J., additional, Snidaric, I., additional, Sobczynska, D., additional, Spanier, F., additional, Stamatescu, V., additional, Stamerra, A., additional, Steinbring, T., additional, Storz, J., additional, Sun, S., additional, Suri , T., additional, Takalo, L., additional, Takami, H., additional, Tavecchio, F., additional, Temnikov, P., additional, Terzi , T., additional, Tescaro, D., additional, Teshima, M., additional, Thaele, J., additional, Tibolla, O., additional, Torres, D. F., additional, Toyama, T., additional, Treves, A., additional, Vogler, P., additional, Wagner, R. M., additional, Zandanel, F., additional, and Zanin, R., additional
- Published
- 2014
- Full Text
- View/download PDF
9. Insights into the high-energy gamma-ray emission of markarian 501 from extensive multifrequency observations in the Fermi era
- Author
-
Abdo, A. A., Ackermann, M., Ajello, M., Allafort, A., Baldini, L., Ballet, J., Barbiellini, G., Baring, M. G., Bastieri, D., Bechtol, K., Bellazzini, R., Berenji, B., Blandford, R. D., Bloom, E. D., Bonamente, E., Borgland, A. W., Bouvier, A., Brandt, T. J., Bregeon, J., Brez, A., Brigida, M., Bruel, P., Buehler, R., Buson, S., Caliandro, G. A., Cameron, R. A., Cannon, A., Caraveo, P. A., Carrigan, S., Casandjian, J. M., Cavazzuti, E., Cecchi, C., Celik, O., Charles, E., Chekhtman, A., Cheung, C. C., Chiang, J., Ciprini, S., Claus, R., Cohen-Tanugi, J., Conrad, J., Cutini, S., Dermer, C. D., de Palma, F., Silva, E. D. E., Drell, P. S., Dubois, R., Dumora, D., Favuzzi, C., Fegan, S. J., Ferrara, E. C., Focke, W. B., Fortin, P., Frailis, M., Fuhrmann, L., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gasparrini, D., Gehrels, N., Germani, S., Giglietto, N., Giordano, F., Giroletti, M., Glanzman, T., Godfrey, G., Grenier, I. A., Guillemot, L., Guiriec, S., Hayashida, M., Hays, E., Horan, D., Hughes, R. E., Johannesson, G., Johnson, A. S., Johnson, W. N., Kadler, M., Kamae, T., Katagiri, H., Kataoka, J., Knodlseder, J., Kuss, M., Lande, J., Latronico, L., Lee, S. H., Lemoine-Goumard, M., Longo, F., Loparco, F., Lott, B., Lovellette, M. N., Lubrano, P., Madejski, G. M., Makeev, A., Max-Moerbeck, W., Mazziotta, M. N., McEnery, J. E., Mehault, J., Michelson, P. F., Mitthumsiri, W., Mizuno, T., Moiseev, A. A., Monte, C., Monzani, M. E., Morselli, A., Moskalenko, I. V., Murgia, S., Naumann-Godo, M., Nishino, S., Nolan, P. L., Norris, J. P., Nuss, E., Ohsugi, T., Okumura, A., Omodei, N., Orlando, E., Ormes, J. F., Paneque, D., Panetta, J. H., Parent, D., Pavlidou, V., Pearson, T. J., Pelassa, V., Pepe, M., Pesce-Rollins, M., Piron, F., Porter, T. A., Raino, S., Rando, R., Razzano, M., Readhead, A., Reimer, A., Reimer, O., Richards, J. L., Ripken, J., Ritz, S., Roth, M., Sadrozinski, H. F. W., Sanchez, D., Sander, A., Scargle, J. D., Sgro, C., Siskind, E. J., Smith, P. D., Spandre, G., Spinelli, P., Stawarz, L., Stevenson, M., Strickman, M. S., Sokolovsky, K. V., Suson, D. J., Takahashi, H., Takahashi, T., Tanaka, T., Thayer, J. B., Thayer, J. G., Thompson, D. J., Tibaldo, L., Torres, F., Tosti, G., Tramacere, A., Uchiyama, Y., Usher, T. L., Vandenbroucke, J., Vasileiou, V., Vilchez, N., Vitale, V., Waite, A. P., Wang, P., Wehrle, A. E., Winer, B. L., Wood, K. S., Yang, Z., Ylinen, T., Zensus, J. A., Ziegler, M., Aleksic, J., Antonelli, L. A., Antoranz, P., Backes, M., Barrio, J. A., Gonzalez, J. B., Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Boller, A., Bonnoli, G., Bordas, P., Tridon, D. B., Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Camara, M., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Dazzi, F., de Angelis, A., del Pozo, E. D., De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. D., Ortega, A. D., Doert, M., Dominguez, A., Prester, D. D., Dorner, D., Doro, M., Elsaesser, D., Ferenc, D., Fonseca, M. V., Font, L., Lopen, R. J. G., Garczarczyk, M., Gaug, M., Giavitto, G., Godinovi, N., Hadasch, D., Herrero, A., Hildebrand, D., Hohne-Monch, D., Hose, J., Hrupec, D., Jogler, T., Klepser, S., Krahenbuhl, T., Kranich, D., Krause, J., La Barbera, A., Leonardo, E., Lindfors, E., Lombardi, S., Lopez, M., Lorenz, E., Majumdar, P., Makariev, E., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldon, J., Moralejo, A., Nieto, D., Nilsson, K., Orito, R., Oya, I., Paoletti, R., Paredes, J. M., Partini, S., Pasanen, M., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, J., Pochon, J., Moroni, P. G. P., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, T., Reinthal, R., Rhode, W., Ribo, M., Rico, J., Rissi, M., Rugamer, S., Saggion, A., Saito, K., Saito, T. Y., Salvati, M., Sanchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpaa, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Storz, J., Strah, N., Struebig, J. C., Suric, T., Takalo, L. O., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Vankov, H., Wagner, R. M., Weitzel, Q., Zabalza, V., Zandanel, F., Zanin, R., Acciari, V. A., Arlen, T., Aune, T., Benbow, W., Boltuch, D., Bradbury, S. M., Buckley, J. H., Bugaev, V., Cesarini, A., Ciupik, L., Cui, W., Dickherber, R., Errando, M., Falcone, A., Finley, J. P., Finnegan, G., Fortson, L., Furniss, A., Galante, N., Gall, D., Gillanders, G. H., Godambe, S., Grube, J., Guenette, R., Gyuk, G., Hanna, D., Holder, J., Huang, D., Hui, C. M., Humensky, T. B., Kaaret, P., Karlsson, N., Kertzman, M., Kieda, D., Konopelko, A., Krawczynski, H., Krennrich, F., Lang, M. J., Maier, G., McArthur, S., McCann, A., McCutcheon, M., Moriarty, P., Mukherjee, R., Ong, R., Otte, N., Pandel, D., Perkins, J. S., Pichel, A., Pohl, M., Quinn, J., Ragan, K., Reyes, L. C., Reynolds, P. T., Roache, E., Rose, H. J., Rovero, A. C., Schroedter, M., Sembroski, G. H., Senturk, G. D., Steele, D., Swordy, S. P., Tesic, G., Theiling, M., Thibadeau, S., Varlotta, A., Vincent, S., Wakely, S. P., Ward, J. E., Weekes, T. C., Weinstein, A., Weisgarber, T., Williams, D. A., Wood, M., Zitzer, B., Villata, M., Raiteri, C. M., Aller, H. D., Aller, M. F., Arkharov, A. A., Blinov, D. A., Calcidese, P., Chen, W. P., Efimova, N. V., Kimeridze, G., Konstantinova, T. S., Kopatskaya, E. N., Koptelova, E., Kurtanidze, O. M., Kurtanidze, S. O., Lahteenmaki, A., Larionov, V. M., Larionova, E. G., Larionova, L. V., Ligustri, R., Morozova, D. A., Nikolashvili, M. G., Sigua, L. A., Troitsky, I. S., Angelakis, E., Capalbi, M., Carraminana, A., Carrasco, L., Cassaro, P., de la Fuente, E., Gurwell, M. A., Kovalev, Y. Y., Kovalev, Y. A., Krichbaum, T. P., Krimm, H. A., Leto, P., Lister, M. L., Maccaferri, G., Moody, J. W., Mori, Y., Nestoras, I., Orlati, A., Pagani, C., Pace, C., Pearson, R., Perri, M., Piner, B. G., Pushkarev, A. B., Ros, E., Sadun, A. C., Sakamoto, T., Tornikoski, M., Yatsu, Y., Zook, A., Fermi, L. A. T. Collaboration Magic Collaboration Veritas Collaboration, Abdo, A. A., Ackermann, M., Ajello, M., Allafort, A., Baldini, L., Ballet, J., Barbiellini, G., Baring, M. G., Bastieri, D., Bechtol, K., Bellazzini, R., Berenji, B., Blandford, R. D., Bloom, E. D., Bonamente, E., Borgland, A. W., Bouvier, A., Brandt, T. J., Bregeon, J., Brez, A., Brigida, M., Bruel, P., Buehler, R., Buson, S., Caliandro, G. A., Cameron, R. A., Cannon, A., Caraveo, P. A., Carrigan, S., Casandjian, J. M., Cavazzuti, E., Cecchi, C., Celik, O., Charles, E., Chekhtman, A., Cheung, C. C., Chiang, J., Ciprini, S., Claus, R., Cohen-Tanugi, J., Conrad, J., Cutini, S., Dermer, C. D., de Palma, F., Silva, E. D. E., Drell, P. S., Dubois, R., Dumora, D., Favuzzi, C., Fegan, S. J., Ferrara, E. C., Focke, W. B., Fortin, P., Frailis, M., Fuhrmann, L., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gasparrini, D., Gehrels, N., Germani, S., Giglietto, N., Giordano, F., Giroletti, M., Glanzman, T., Godfrey, G., Grenier, I. A., Guillemot, L., Guiriec, S., Hayashida, M., Hays, E., Horan, D., Hughes, R. E., Johannesson, G., Johnson, A. S., Johnson, W. N., Kadler, M., Kamae, T., Katagiri, H., Kataoka, J., Knodlseder, J., Kuss, M., Lande, J., Latronico, L., Lee, S. H., Lemoine-Goumard, M., Longo, F., Loparco, F., Lott, B., Lovellette, M. N., Lubrano, P., Madejski, G. M., Makeev, A., Max-Moerbeck, W., Mazziotta, M. N., McEnery, J. E., Mehault, J., Michelson, P. F., Mitthumsiri, W., Mizuno, T., Moiseev, A. A., Monte, C., Monzani, M. E., Morselli, A., Moskalenko, I. V., Murgia, S., Naumann-Godo, M., Nishino, S., Nolan, P. L., Norris, J. P., Nuss, E., Ohsugi, T., Okumura, A., Omodei, N., Orlando, E., Ormes, J. F., Paneque, D., Panetta, J. H., Parent, D., Pavlidou, V., Pearson, T. J., Pelassa, V., Pepe, M., Pesce-Rollins, M., Piron, F., Porter, T. A., Raino, S., Rando, R., Razzano, M., Readhead, A., Reimer, A., Reimer, O., Richards, J. L., Ripken, J., Ritz, S., Roth, M., Sadrozinski, H. F. W., Sanchez, D., Sander, A., Scargle, J. D., Sgro, C., Siskind, E. J., Smith, P. D., Spandre, G., Spinelli, P., Stawarz, L., Stevenson, M., Strickman, M. S., Sokolovsky, K. V., Suson, D. J., Takahashi, H., Takahashi, T., Tanaka, T., Thayer, J. B., Thayer, J. G., Thompson, D. J., Tibaldo, L., Torres, F., Tosti, G., Tramacere, A., Uchiyama, Y., Usher, T. L., Vandenbroucke, J., Vasileiou, V., Vilchez, N., Vitale, V., Waite, A. P., Wang, P., Wehrle, A. E., Winer, B. L., Wood, K. S., Yang, Z., Ylinen, T., Zensus, J. A., Ziegler, M., Aleksic, J., Antonelli, L. A., Antoranz, P., Backes, M., Barrio, J. A., Gonzalez, J. B., Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Boller, A., Bonnoli, G., Bordas, P., Tridon, D. B., Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Camara, M., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Dazzi, F., de Angelis, A., del Pozo, E. D., De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. D., Ortega, A. D., Doert, M., Dominguez, A., Prester, D. D., Dorner, D., Doro, M., Elsaesser, D., Ferenc, D., Fonseca, M. V., Font, L., Lopen, R. J. G., Garczarczyk, M., Gaug, M., Giavitto, G., Godinovi, N., Hadasch, D., Herrero, A., Hildebrand, D., Hohne-Monch, D., Hose, J., Hrupec, D., Jogler, T., Klepser, S., Krahenbuhl, T., Kranich, D., Krause, J., La Barbera, A., Leonardo, E., Lindfors, E., Lombardi, S., Lopez, M., Lorenz, E., Majumdar, P., Makariev, E., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldon, J., Moralejo, A., Nieto, D., Nilsson, K., Orito, R., Oya, I., Paoletti, R., Paredes, J. M., Partini, S., Pasanen, M., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, J., Pochon, J., Moroni, P. G. P., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, T., Reinthal, R., Rhode, W., Ribo, M., Rico, J., Rissi, M., Rugamer, S., Saggion, A., Saito, K., Saito, T. Y., Salvati, M., Sanchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpaa, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Storz, J., Strah, N., Struebig, J. C., Suric, T., Takalo, L. O., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Vankov, H., Wagner, R. M., Weitzel, Q., Zabalza, V., Zandanel, F., Zanin, R., Acciari, V. A., Arlen, T., Aune, T., Benbow, W., Boltuch, D., Bradbury, S. M., Buckley, J. H., Bugaev, V., Cesarini, A., Ciupik, L., Cui, W., Dickherber, R., Errando, M., Falcone, A., Finley, J. P., Finnegan, G., Fortson, L., Furniss, A., Galante, N., Gall, D., Gillanders, G. H., Godambe, S., Grube, J., Guenette, R., Gyuk, G., Hanna, D., Holder, J., Huang, D., Hui, C. M., Humensky, T. B., Kaaret, P., Karlsson, N., Kertzman, M., Kieda, D., Konopelko, A., Krawczynski, H., Krennrich, F., Lang, M. J., Maier, G., McArthur, S., McCann, A., McCutcheon, M., Moriarty, P., Mukherjee, R., Ong, R., Otte, N., Pandel, D., Perkins, J. S., Pichel, A., Pohl, M., Quinn, J., Ragan, K., Reyes, L. C., Reynolds, P. T., Roache, E., Rose, H. J., Rovero, A. C., Schroedter, M., Sembroski, G. H., Senturk, G. D., Steele, D., Swordy, S. P., Tesic, G., Theiling, M., Thibadeau, S., Varlotta, A., Vincent, S., Wakely, S. P., Ward, J. E., Weekes, T. C., Weinstein, A., Weisgarber, T., Williams, D. A., Wood, M., Zitzer, B., Villata, M., Raiteri, C. M., Aller, H. D., Aller, M. F., Arkharov, A. A., Blinov, D. A., Calcidese, P., Chen, W. P., Efimova, N. V., Kimeridze, G., Konstantinova, T. S., Kopatskaya, E. N., Koptelova, E., Kurtanidze, O. M., Kurtanidze, S. O., Lahteenmaki, A., Larionov, V. M., Larionova, E. G., Larionova, L. V., Ligustri, R., Morozova, D. A., Nikolashvili, M. G., Sigua, L. A., Troitsky, I. S., Angelakis, E., Capalbi, M., Carraminana, A., Carrasco, L., Cassaro, P., de la Fuente, E., Gurwell, M. A., Kovalev, Y. Y., Kovalev, Y. A., Krichbaum, T. P., Krimm, H. A., Leto, P., Lister, M. L., Maccaferri, G., Moody, J. W., Mori, Y., Nestoras, I., Orlati, A., Pagani, C., Pace, C., Pearson, R., Perri, M., Piner, B. G., Pushkarev, A. B., Ros, E., Sadun, A. C., Sakamoto, T., Tornikoski, M., Yatsu, Y., Zook, A., and Fermi, L. A. T. Collaboration Magic Collaboration Veritas Collaboration
- Abstract
We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size less than or similar to 0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (similar or equal to 10(44) erg s(-1)) constitutes only a small fraction (similar to 10(-3)) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that su
- Published
- 2011
10. Spectral energy distribution of markarian 501: Quiescent state versus extreme outburst
- Author
-
Acciari, V. A., Arlen, T., Aune, T., Beilicke, M., Benbow, W., Bottcher, M., Boltuch, D., Bradbury, S. M., Buckley, J. H., Bugaev, V., Cannon, A., Cesarini, A., Ciupik, L., Cui, W., Dickherber, R., Duke, C., Errando, M., Falcone, A., Finley, J. P., Finnegan, G., Fortson, L., Furniss, A., Galante, N., Gall, D., Godambe, S., Grube, J., Guenette, R., Gyuk, G., Hanna, D., Holder, J., Huang, D., Hui, C. M., Humensky, T. B., Imran, A., Kaaret, P., Karlsson, N., Kertzman, M., Kieda, D., Konopelko, A., Krawczynski, H., Krennrich, F., Madhavan, A. S., Maier, G., McArthur, S., McCann, A., Moriarty, P., Ong, R. A., Otte, A. N., Pandel, D., Perkins, J. S., Pichel, A., Pohl, M., Quinn, J., Ragan, K., Reyes, L. C., Reynolds, P. T., Roache, E., Rose, H. J., Schroedter, M., Sembroski, G. H., Steele, D., Swordy, S. P., Theiling, M., Thibadeau, S., Varlotta, A., Vassiliev, V. V., Vincent, S., Wakely, S. P., Ward, J. E., Weekes, T. C., Weinstein, A., Weisgarber, T., Williams, D. A., Wood, M., Zitzer, B., Aleksic, J., Antonelli, L. A., Antoranz, P., Backes, M., Barrio, J. A., Bastieri, D., Gonzalez, J. B., Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Boller, A., Bonnoli, G., Bordas, P., Tridon, D. B., Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Camara, M., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Dazzi, F., De Angelis, A., Del Pozo, E. D., De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. D., Ortega, A. D., Doert, M., Dominguez, A., Prester, D. D., Dorner, D., Doro, M., Elsaesser, D., Ferenc, D., Fonseca, M. V., Font, L., Lopez, R. J. G., Garczarczyk, M., Gaug, M., Giavitto, G., Godinovic, N., Hadasch, D., Herrero, A., Hildebrand, D., Hohne-Monch, D., Hose, J., Hrupec, D., Jogler, T., Klepser, S., Krahenbuhl, T., Kranich, D., Krause, J., La Barbera, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lorenz, E., Majumdar, P., Makariev, M., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldon, J., Moralejo, A., Nieto, D., Nilsson, K., Orito, R., Oya, I., Paoletti, R., Paredes, J. M., Partini, S., Pasanen, M., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Pochon, J., Prada, F., Moroni, P. G. P., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Reinthal, R., Rhode, W., Ribo, M., Rico, J., Rissi, M., Rugamer, S., Saggion, A., Saito, K., Saito, T. Y., Salvati, M., Sanchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpaa, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Storz, J., Strah, N., Struebig, J. C., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Torres, D. F., Vankov, H., Wagner, R. M., Weitzel, Q., Zabalza, V., Zandanel, F., Zanin, R., Paneque, D., Hayashida, M., Acciari, V. A., Arlen, T., Aune, T., Beilicke, M., Benbow, W., Bottcher, M., Boltuch, D., Bradbury, S. M., Buckley, J. H., Bugaev, V., Cannon, A., Cesarini, A., Ciupik, L., Cui, W., Dickherber, R., Duke, C., Errando, M., Falcone, A., Finley, J. P., Finnegan, G., Fortson, L., Furniss, A., Galante, N., Gall, D., Godambe, S., Grube, J., Guenette, R., Gyuk, G., Hanna, D., Holder, J., Huang, D., Hui, C. M., Humensky, T. B., Imran, A., Kaaret, P., Karlsson, N., Kertzman, M., Kieda, D., Konopelko, A., Krawczynski, H., Krennrich, F., Madhavan, A. S., Maier, G., McArthur, S., McCann, A., Moriarty, P., Ong, R. A., Otte, A. N., Pandel, D., Perkins, J. S., Pichel, A., Pohl, M., Quinn, J., Ragan, K., Reyes, L. C., Reynolds, P. T., Roache, E., Rose, H. J., Schroedter, M., Sembroski, G. H., Steele, D., Swordy, S. P., Theiling, M., Thibadeau, S., Varlotta, A., Vassiliev, V. V., Vincent, S., Wakely, S. P., Ward, J. E., Weekes, T. C., Weinstein, A., Weisgarber, T., Williams, D. A., Wood, M., Zitzer, B., Aleksic, J., Antonelli, L. A., Antoranz, P., Backes, M., Barrio, J. A., Bastieri, D., Gonzalez, J. B., Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Boller, A., Bonnoli, G., Bordas, P., Tridon, D. B., Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Camara, M., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Dazzi, F., De Angelis, A., Del Pozo, E. D., De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. D., Ortega, A. D., Doert, M., Dominguez, A., Prester, D. D., Dorner, D., Doro, M., Elsaesser, D., Ferenc, D., Fonseca, M. V., Font, L., Lopez, R. J. G., Garczarczyk, M., Gaug, M., Giavitto, G., Godinovic, N., Hadasch, D., Herrero, A., Hildebrand, D., Hohne-Monch, D., Hose, J., Hrupec, D., Jogler, T., Klepser, S., Krahenbuhl, T., Kranich, D., Krause, J., La Barbera, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lorenz, E., Majumdar, P., Makariev, M., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldon, J., Moralejo, A., Nieto, D., Nilsson, K., Orito, R., Oya, I., Paoletti, R., Paredes, J. M., Partini, S., Pasanen, M., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Pochon, J., Prada, F., Moroni, P. G. P., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Reinthal, R., Rhode, W., Ribo, M., Rico, J., Rissi, M., Rugamer, S., Saggion, A., Saito, K., Saito, T. Y., Salvati, M., Sanchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpaa, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Storz, J., Strah, N., Struebig, J. C., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Torres, D. F., Vankov, H., Wagner, R. M., Weitzel, Q., Zabalza, V., Zandanel, F., Zanin, R., Paneque, D., and Hayashida, M.
- Abstract
The very high energy (VHE; E > 100 GeV) blazar Markarian 501 (Mrk 501) has a well-studied history of extreme spectral variability and is an excellent laboratory for studying the physical processes within the jets of active galactic nuclei. However, there are few detailed multiwavelength studies of Mrk 501 during its quiescent state, due to its low luminosity. A short-term multiwavelength study of Mrk 501 was coordinated in 2009 March, focusing around a multi-day observation with the Suzaku X-ray satellite and including gamma-ray data from VERITAS, MAGIC, and the Fermi Gamma-ray Space Telescope with the goal of providing a well-sampled multiwavelength baseline measurement of Mrk 501 in the quiescent state. The results of these quiescent-state observations are compared to the historically extreme outburst of 1997 April 16, with the goal of examining variability of the spectral energy distribution (SED) between the two states. The derived broadband SED shows the characteristic double-peaked profile. We find that the X-ray peak shifts by over two orders of magnitude in photon energy between the two flux states while the VHE peak varies little. The limited shift in the VHE peak can be explained by the transition to the Klein-Nishina (KN) regime. Synchrotron self-Compton models are matched to the data and the implied KN effects are explored.
- Published
- 2011
11. Ethnobotanical-Directed Discovery of the Antihyperglycemic Properties of Cryptolepine: Its Isolation from Cryptolepis sanguinolenta, Synthesis, and in Vitro and in Vivo Activities
- Author
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Bierer, D. E., Fort, D. M., Mendez, C. D., Luo, J., Imbach, P. A., Dubenko, L. G., Jolad, S. D., Gerber, R. E., Litvak, J., Lu, Q., Zhang, P., Reed, M. J., Waldeck, N., Bruening, R. C., Noamesi, B. K., Hector, R. F., Carlson, T. J., and King, S. R.
- Abstract
Using an ethnobotanical approach in combination with in vivo-guided fractionation as a means for lead discovery, cryptolepine was isolated as an antihyperglycemic component of Cryptolepis sanguinolenta. Two syntheses of cryptolepine, including an unambiguous synthesis, are reported. The hydroiodide, hydrochloride, and hydrotrifluoromethanesulfonate (hydrotriflate) salts of cryptolepine were synthesized, and a comparison of their spectral properties and their in vitro activities in a 3T3-L1 glucose transport assay is made. Cryptolepine and its salt forms lower blood glucose in rodent models of type II diabetes. While a number of bioactivities have been reported for cryptolepine, this is the first report that cryptolepine posesses antihyperglycemic properties.
- Published
- 1998
12. MAGIC upper limits on the GRB 090102 afterglow
- Author
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Aleksić, J., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., De Almeida, U. B., Barrio, J. A., Gonzalez, J. B., Bednarek, W., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Boller, A., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Fidalgo, D. C., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Cossio, L., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., Mendez, C. D., Doert, M., Dominguez, A., Prester, D. D., Dorner, D., Doro, M., Eisenacher, D., Elsaesser, D., Farina, E., Ferenc, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Lopez, R. J. G., Garczarczyk, M., Terrats, D. G., Gaug, M., Giavitto, G., Godinovic, N., Munoz, A. G., Gozzini, S. R., Hadamek, A., Hadasch, D., Herrero, A., Hose, J., Hrupec, D., Idec, W., Kadenius, V., Knoetig, M. L., Krahenbuhl, T., Krause, J., Kushida, J., Barbera, A. L., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., Lopez-Coto, R., Lopez, M., Lopez-Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martinez, M., Masbou, J., Mazin, D., Menzel, U., Meucci, M., Miranda, J. M., Mirzoyan, R., Moldon, J., Moralejo, A., Munar-Adrover, P., Nakajima, D., Niedzwiecki, A., Nilsson, K., Nowak, N., Orito, R., Overkemping, A., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Partini, S., Persic, M., Prada, F., Moroni, P. G. P., Prandini, E., Preziuso, S., Puljak, I., Reichardt, I., Reinthal, R., Rhode, W., Ribo, M., Rico, J., Garcia, J. R., Rugamer, S., Saggion, A., Saito, K., Saito, T., Salvati, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shore, S. N., Sillanpaa, A., Sitarek, J., Snidaric, I., Sobczynska, D., Spanier, F., Stamatescu, V., Stamerra, A., Storz, J., Sun, S., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Thaele, J., Tibolla, O., Torres, D. F., Toyama, T., Treves, A., Uellenbeck, M., Vogler, P., Wagner, R. M., Weitzel, Q., Zandanel, F., Zanin, R., Bouvier, A., Hayashida, M., Tajima, H., and Longo, F.
- Subjects
7. Clean energy - Abstract
Monthly notices of the Royal Astronomical Society 437(4), 3103 - 3111 (2014). doi:10.1093/mnras/stt2041, Published by Wiley-Blackwell, Oxford [u.a.]
13. Novel antihyperglycemic terpenoid-quinones from Pycnanthus angolensis.
- Author
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Fort DM, Ubillas RP, Mendez CD, Jolad SD, Inman WD, Carney JR, Chen JL, Ianiro TT, Hasbun C, Bruening RC, Luo J, Reed MJ, Iwu M, Carlson TJ, King SR, Bierer DE, and Cooper R
- Subjects
- Africa, Animals, Blood Glucose metabolism, Body Weight drug effects, Diabetes Mellitus blood, Diabetes Mellitus genetics, Eating drug effects, Fatty Acids, Unsaturated pharmacology, Hypoglycemic Agents pharmacology, Magnetic Resonance Spectroscopy, Male, Mice, Mice, Inbred C57BL, Mice, Obese, Naphthoquinones pharmacology, Plant Extracts chemistry, Plant Leaves chemistry, Plant Stems chemistry, Fatty Acids, Unsaturated isolation & purification, Hypoglycemic Agents isolation & purification, Naphthoquinones isolation & purification, Plants, Medicinal chemistry
- Abstract
Two new compounds, pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from leaves and stems of the African plant, Pycnanthus angolensis (Welw.) Warb (Myristicaceae), by bioassay-guided fractionation of an ethanolic extract using a diabetic mouse model. Pycnanthuquinones A and B are the first representatives of a novel terpenoid-type quinone skeleton, and both compounds possess significant antihyperglycemic activity.
- Published
- 2000
- Full Text
- View/download PDF
14. Antihyperglycemic acetylenic glucosides from Bidens pilosa.
- Author
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Ubillas RP, Mendez CD, Jolad SD, Luo J, King SR, Carlson TJ, and Fort DM
- Subjects
- Acetylene chemistry, Animals, Diabetes Mellitus, Type 2 drug therapy, Glucosides pharmacology, Glucosides therapeutic use, Hypoglycemic Agents pharmacology, Hypoglycemic Agents therapeutic use, Male, Mice, Mice, Inbred C57BL, Asteraceae chemistry, Glucosides isolation & purification, Hypoglycemic Agents isolation & purification
- Abstract
In vivo bioassay-guided fractionation of the aqueous alcohol extract of the aerial parts of Bidens pilosa Sch. Bip. var. radiata (Asteraceae) using C57 BL/Ks-db/db mice as a model for type 2 diabetes, yielded two known polyacetylenic glucosides, identified as 2-beta-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-+ ++triyne (1) and 3-beta-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,1 2-triyne (2). A 3:2 mixture of compounds 1 and 2 effected a significant drop in blood glucose.
- Published
- 2000
- Full Text
- View/download PDF
15. Antihyperglycemic furanosesquiterpenes from commiphora myrrha.
- Author
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Ubillas RP, Mendez CD, Jolad SD, Luo J, King SR, Carlson TJ, and Fort DM
- Subjects
- Animals, Diabetes Mellitus, Experimental drug therapy, Hypoglycemic Agents pharmacology, Hypoglycemic Agents therapeutic use, Mice, Mice, Inbred C57BL, Hypoglycemic Agents isolation & purification, Plants, Medicinal chemistry
- Published
- 1999
- Full Text
- View/download PDF
16. Novel terpenoid-type quinones isolated from Pycnanthus angolensis of potential utility in the treatment of type 2 diabetes.
- Author
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Luo J, Cheung J, Yevich EM, Clark JP, Tsai J, Lapresca P, Ubillas RP, Fort DM, Carlson TJ, Hector RF, King SR, Mendez CD, Jolad SD, and Reaven GM
- Subjects
- Adipocytes drug effects, Adipocytes metabolism, Animals, Blood Glucose drug effects, Cells, Cultured, Diabetes Mellitus, Experimental blood, Diabetes Mellitus, Experimental drug therapy, Diabetes Mellitus, Type 2 blood, Disease Models, Animal, Eating drug effects, Insulin blood, Male, Mice, Mice, Inbred C57BL, Plants, Medicinal chemistry, Trees chemistry, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents pharmacology, Naphthoquinones pharmacology, Plant Extracts pharmacology
- Abstract
Using an ethnomedical-based drug discovery program, two previously unknown compounds (SP-18904 and SP-18905) from Pycnanthus angolensis were isolated that lower glucose concentrations in mouse models of type 2 diabetes. SP-18904 and SP-18905 are terpenoid-type quinones that significantly lowered plasma glucose concentration (p <.05) when given orally to either ob/ob or db/db mice, both of which are hyperglycemic and hyperinsulinemic. The antihyperglycemic actions of SP-18904 and SP-18905 were associated with significant decreases in plasma insulin concentrations (p <.05), suggesting that both compounds lowered glucose by enhancing insulin-mediated glucose uptake. This was supported by the insulin suppression test in ob/ob mice. Studies in hyperglycemic, insulin-deficient mice and in vitro experiments on 3T3-L1 adipocytes further supported this conclusion. As such, these two terpenoid-type quinones represent a new class of compounds of potential use in the treatment of type 2 diabetes.
- Published
- 1999
17. Cryptolepis sanguinolenta: an ethnobotanical approach to drug discovery and the isolation of a potentially useful new antihyperglycaemic agent.
- Author
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Luo J, Fort DM, Carlson TJ, Noamesi BK, nii-Amon-Kotei D, King SR, Tsai J, Quan J, Hobensack C, Lapresca P, Waldeck N, Mendez CD, Jolad SD, Bierer DE, and Reaven GM
- Subjects
- Adipose Tissue cytology, Adipose Tissue drug effects, Adipose Tissue metabolism, Aged, Alkaloids isolation & purification, Alkaloids pharmacology, Alkaloids therapeutic use, Animals, Blood Glucose drug effects, Blood Glucose metabolism, Cell Line, Diabetes Mellitus, Type 2 drug therapy, Drug Evaluation, Preclinical, Ethics, Pharmacy, Glucose pharmacokinetics, Humans, Hypoglycemic Agents chemistry, Hypoglycemic Agents isolation & purification, Hypoglycemic Agents pharmacology, Indole Alkaloids, Insulin blood, Male, Mice, Mice, Inbred C57BL, Mice, Obese, Middle Aged, Vasodilator Agents isolation & purification, Vasodilator Agents pharmacology, Vasodilator Agents therapeutic use, Indoles, Plants, Medicinal chemistry, Quinolines
- Abstract
Evidence has been published that a wide array of plant-derived active principles, representing numerous classes of chemical compounds, demonstrate activity consistent with their possible use in the treatment of patients with Type 2 diabetes mellitus (DM). Despite these interesting observations, to date, metformin is the only ethical drug approved for treatment of Type 2 DM derived from a medicinal plant. Why is this so, given the fact that higher plants are such a potential source of new drugs? The answer to this rhetorical question may lie in the reliance of most pharmaceutical companies on random, in vitro, mechanism-based, high throughput screening in the initial phases of plant drug research. In this article we describe an alternative pathway to discovery of drugs for the treatment of Type 2 DM: on based on an ethnomedical approach, involving ethnobotany and traditional medicine. In particular, we present evidence that cryptolepine, an indoloquinolone alkaloid isolated from Cryptolepis sanguinolenta, significantly lowers glucose when given orally to a mouse model of diabetes. The antihyperglycaemic effect of cryptolepine leads to a significant decline in plasma insulin concentration, associated with evidence of an enhancement in insulin-mediated glucose disposal. Finally, cryptolepine increases glucose uptake by 3T3-L1 cells. These data permit us to conclude that an ethnobotanical approach to drug discovery can identify a potentially useful drug for the treatment of Type 2 DM.
- Published
- 1998
- Full Text
- View/download PDF
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