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The human T-cell lymphotropic virus-1 (HTLV-1) affects worldwide population; the estimated number of currently infected individuals is 10-20 million. In this report, we describe the clinical findings of three family members with vertical transmission of HTLV-1. This case report highlights the importance of healthcare providers who have optimal knowledge about HTLV-1 including its transmission and pertinent attributes, and who are able to provide affected individuals with adequate information regarding their condition.

Dermatoscopy of melanocytic lesions has guided the decision of when or not to biopsy a lesion. The use of this tool has increased clinical examination's sensitivity and specificity in 89% and 96% respectively. However, dermatoscopic evaluation of amelanotic or hypomelanotic melanomas, as well as metastases, can be difficult. There is still no standardization for the analysis of these pathologies, which relies mostly on their vascular pattern. We describe the dermatoscopy of acral metastatic amelanotic melanoma. A dermatoscopia das lesões melanocíticas tem auxiliado na decisão de biopsiar ou não uma lesão. A utilização desta ferramenta aumentou a sensibilidade e a especificidade do diagnóstico para 89% e 96%, respectivamente. No entanto, a avaliação dermatoscópica de melanomas amelanóticos ou hipomelanóticos, bem como a de metástases cutâneas, pode ser difícil. Ainda falta uma padronização para a análise destas patologias, que se baseia, majoritariamente, no seu padrão vascular. Descreve-se a dermatoscopia de melanoma metastático amelanótico acral.

Epidermolytic ichthyosis is a rare autosomal dominant disease that manifests at birth with fragile blisters and erosions that evolve into hyperkeratotic lesions associated or not with erythroderma. When the disease is associated with a mutation in cytokeratin 1, it may be related to hyperkeratosis of palms and soles, but this is not usually found when cytokeratin 10 is mutated. The disease can present in a mosaic form, due to post zygotic mutation of the gene involved, constituting an individual formed by two populations of genetically distinct cells - one carrier of the mutation and the other without it. We report a case of mosaic epidermolytic ichthyosis diagnosed in a female patient. A ictiose epidermolítica é doença autossômica dominante rara que se manifesta ao nascer com bolhas frágeis e erosões que evoluem para lesões hiperceratóticas associadas ou não a eritrodermia. Quando associada à mutação da citoqueratina 1 pode estar relacionada à hiperceratose palmoplantar, porém quando o defeito está relacionado à mutação da citoqueratina 10, este achado não é comumente encontrado. A doença pode ainda se manifestar em forma de mosaicismo somático, devido a mutação pós zigótica do gene envolvido, formando um indivíduo com duas populações de células geneticamente distintas, uma com a mutação e outra sem a mutação. Relata-se um caso de ictiose epidermolítica em mosaico em paciente do sexo feminino.

p. 989-991 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-08T15:52:35Z No. of bitstreams: 1 0365-0596-abd-88-06-0989.pdf: 181755 bytes, checksum: e1be8a51b1801c92078436401d19bdda (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T16:06:46Z (GMT) No. of bitstreams: 1 0365-0596-abd-88-06-0989.pdf: 181755 bytes, checksum: e1be8a51b1801c92078436401d19bdda (MD5) Made available in DSpace on 2014-09-09T16:06:46Z (GMT). No. of bitstreams: 1 0365-0596-abd-88-06-0989.pdf: 181755 bytes, checksum: e1be8a51b1801c92078436401d19bdda (MD5) Previous issue date: 2013 Dermatoscopy of melanocytic lesions has guided the decision of when or not to biopsy a lesion. The use of this tool has increased clinical examination's sensitivity and specificity in 89% and 96% respectively. However, dermatoscopic evaluation of amelanotic or hypomelanotic melanomas, as well as metastases, can be difficult. There is still no standardization for the analysis of these pathologies, which relies mostly on their vascular pattern. We describe the dermatoscopy of acral metastatic amelanotic melanoma.