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378 results on '"Menabue, Ledi"'

20. Amide group coordination to the Pb2+ ion

Author

Battistuzzi, Gianantonio, Borsari, Marco, Menabue, Ledi, Saladini, Monica, and Sola, Marco

Subjects
Lead compounds -- Research, Ligands -- Analysis, Complex compounds -- Spectra, Organometallic compounds -- Research, Chemistry
Abstract

Pb2+ effectively promotes peptide and sulfonamide nitrogen deprotonation in binary and ternary complexes of lead with N-carbonyl and N-sulfonyl amino acid ligands. Molecular structural studies of complexes such as Pb(N-tosylglycinato-N,O)(H2O), (Pb(N-benzoylglycinato-O)2(H2O)2).2H2O and Pb(N-tosylglycinato-O)2(bpy) reveal that the compounds are polymeric. The compounds have six- to eight-coordinate metals exhibiting distorted coordination geometries that suggest a stereochemically active metal lone pair.

Published
1996

28. Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)

Author

Sánchez Salcedo, Sandra, Malavasi, Gianluca, Salinas Sánchez, Antonio J., Lusvardi, Gigliola, Rigamonti, Luca, Menabue, Ledi, Vallet Regí, María Dulce Nombre, Sánchez Salcedo, Sandra, Malavasi, Gianluca, Salinas Sánchez, Antonio J., Lusvardi, Gigliola, Rigamonti, Luca, Menabue, Ledi, and Vallet Regí, María Dulce Nombre

Abstract

Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO2–yCaO–zP2O5–5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2–15CaO–5P2O5 MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications., Unión Europea. Horizonte 2020, Ministerio de Economía y Competitividad (MINECO), Instituto de Salud Carlos III (ISCIII), University of Modena and Reggio Emilia “Progetto Mobilità Internazionale”, Depto. de Química en Ciencias Farmacéuticas, Fac. de Farmacia, TRUE, pub

Published
2018

30. Qualitative and quantitative structure-property relationships analysis of multicomponent potential bioglasses

Author

Linati, Laura, Mustarelli, Piercarlo, Lusvardi, Gigliola, Segre, Ulderico, Malavasi, Gianluca, Menabue, Ledi, and Menziami, M. Christina

Subjects
Glass -- Chemical properties, Glass -- Structure, Chemistry, Analytic -- Quantitative, Glass research, Chemicals, plastics and rubber industries
Abstract

The applicability of the quantitative structure-activity relationship approach for the rationalization and prediction of the technology-related properties of a series of complex multicomponent glasses are tested. The statistical models obtained by making use of structural descriptors with high information content can be considered as useful so as to exploit and rationalize the large amount of data derived by molecular simulations and to gain further insight into the physical process that determines the properties of interest.

Published
2005

31. CATALYTIC BIOACTIVE GLASSES: CATALASE MIMETIC ACTIVITY, AN EXAMPLE

Author

Malavasi, Gianluca, Nicolini, Valentina, Gambuzzi, Elisa, Menabue, Ledi, Lusvardi, Gigliola, Pedone, Alfonso, Benedetti, Francesco, Luches, Paola, D'Addato, Sergio, and Valeri, Sergio

Subjects
bioactivity, Cerium, bioactivity, catalase mimetic activity, Cerium, catalase mimetic activity
Published
2016

32. Development of mesoporous bioactive glasses able to release antibacterial Ga3+ ions

Author

Lusvardi Gigliola, Menabue Ledi, Sanchez-Salcedo Sandra, Malavasi Gianluca, Salinas Sanchez Antonio, and Vallet-Regi Maria

Subjects
Histology, Materials science, Biomedical Engineering, Bioengineering, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Ion, Chemical engineering, 0210 nano-technology, Mesoporous material, Biotechnology
Published
2016
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38. Bioglasses: glasses for medical applications

Author

Lusvardi, Gigliola, Malavasi, Gianluca, Menabue, Ledi, Menziani, Maria Cristina, and Pedone, Alfonso

Subjects
synthesis, medical applications, bioglasses, synthesis, medical applications, bioglasses
Published
2013

40. The role of coordination chemistry in the development of innovative Gallium-based bioceramics: the case of Curcumin

Author

Menabue Ledi, Morterra Claudio, Pignedoli Francesca, Saladini Monica, Ferrari Erika, Malavasi Gianluca, Fantini Francesca, Aina Valentina, and Lusvardi Gigliola

Subjects
chemistry.chemical_classification, Active ingredient, Materials science, Metal ions in aqueous solution, Gallium-based bioactive glasses, General Chemistry, gel glasses, curcumin, bioactivity, drug delivery, Free radical scavenger, Coordination complex, chemistry.chemical_compound, chemistry, Drug delivery, Materials Chemistry, Curcumin, Organic chemistry, Chelation, Lewis acids and bases, dryg delivery, biomaterials
Abstract

Curcumin, an active ingredient in the traditional Ayurvedic herbal remedy [Curcuma longa L.], is nowadays also employed in western medicine for its pleiotropic activities, ranging from anticancer to its free radical scavenger ability. These features are related to curcumin's function as a metal chelator, especially being selective for hard Lewis acids, such as Ga3+ which has interesting pharmacological activities. We report the synthesis and characterization of bioactive gel and mesoporous Ga-containing phospho-silicate glasses loaded with curcumin, in which, for the first time, the design of novel drug delivery systems takes advantage of coordination chemistry. In particular, it was found that: (i) there is a direct correlation between the external surface area and the amount of loaded curcumin; (ii) the presence of Ga3+ species on the surface increases the quantity of drug molecules uploaded and slows down their release in the biological medium (SBF), hinting a coordination-like interaction between curcumin and the surface metal ions; (iii) curcumin molecules released in the SBF solution stabilize Ga3+ ions, avoiding their precipitation.

Published
2011

41. Evidence of Catalase Mimetic Activity in Ce3+/Ce4+ Doped Bioactive Glasses

Author

Nicolini, Valentina, primary, Gambuzzi, Elisa, additional, Malavasi, Gianluca, additional, Menabue, Ledi, additional, Menziani, Maria Cristina, additional, Lusvardi, Gigliola, additional, Pedone, Alfonso, additional, Benedetti, Francesco, additional, Luches, Paola, additional, D’Addato, Sergio, additional, and Valeri, Sergio, additional

Published
2015
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