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3 results on '"Memon, Abdul H."'

1. Anti-uterine fibroid effect of standardized labisia pumila var. Alata extracts in vitro and in human uterine fibroid cancer xenograft model

Author

Zakaria, Norfahana, Mohd, Khamsah S., Saeed, Mohammed A. A., Hassan, Loiy E. A., Shafaei Darestani, Armaghan, Al-Suede, Fouad S. R., Memon, Abdul H., Ismail, Zhari, Zakaria, Norfahana, Mohd, Khamsah S., Saeed, Mohammed A. A., Hassan, Loiy E. A., Shafaei Darestani, Armaghan, Al-Suede, Fouad S. R., Memon, Abdul H., and Ismail, Zhari

Abstract

Background: Uterine fibroids are a common type of solid tumor presenting in women of reproductive age. There are very few alternative treatment available from conventional treatment involving surgeries. Labisia pumila var. alata or locally known as ‘Kacip Fatimah’ was widely used as traditional medicine in Malaysia. This plant has been used to maintain a healthy female reproductive system. The present study aimed to evaluate anti fibroid potential of L. pumila extracts through in vitro apoptosis activity against uterine leiomyoma cells (SK-UT-1) and in uterine leiomyoma xenograft model. Evaluation of bioactive markers content were also carried out. Methods: Apoptotic induction of the extracts was determined by morphological examination of AO/PI dual staining assay by flourescent microscopy and flow cytometry analysis on Annexin V-FITC/PI stained cells. In vivo study was done in immune-compromised mouse xenograft model. HPLC analysis was employed to quantify marker compounds. Results: Morphological analysis showed L. pumila induced apoptosis in a dose dependent manner against SK-UT-1 cells. In vivo study indicated that L. pumila significantly suppressed the growth of uterine fibroid tumor. All tested extracts contain bioactive marker of gallic acid and cafeic acid. Conclusion: This work provide significant data of the potential of L. pumila in management of uterine fibroids.

Published
2020

2. Maximum Power Tracking System Based on Power Electronic Topology for Wind Energy Conversion System Applications

Author

Hussain, Musavir, Baloch, Mazhar H., Umer, Farhana, Memon, Abdul H., and Pathan, Noman K.

Subjects
Physics::Space Physics, variable speed, wind-generator system (WGS), boost converter, Physics::Atmospheric and Oceanic Physics, maximum power tracker system (MPTS)
Abstract

Wind energy has emerged as a dominant alternative power generation source. Conventional energy resources are depleting and their increasing cost cannot be ignored. Wind energy has taken an important role in replacing fossil fuels and nuclear energy. However, optimal exploitation of wind energy systems has remained a thought-provoking problem due to the nonlinear behavior of the wind speed. Distribution generation system and isolated micro-grid (MG) are mainly used in a wind energy system in order to utilize maximum potential of wind through the maximum power tracking algorithm based on DCDC boost power electronic converter. In this paper, authors propose a technique which is effectively workable, highly reliable, of low cost and induces less mechanical stress on the wind generator system (WGS). Experimental results of the proposed system verify that the effectiveness near optimal WGS output power increased approximately up to 50%. Thus, better exploitation of the available wind power is obtained under low wind speeds.

Published
2018
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3. Anti-uterine fibroid effect of standardized labisia pumila var. Alata extracts in vitro and in human uterine fibroid cancer xenograft model

Author

Zakaria, Norfahana, Mohd, Khamsah S., Saeed, Mohammed A. A., Hassan, Loiy E. A., Shafaei Darestani, Armaghan, Al-Suede, Fouad S. R., Memon, Abdul H., Ismail, Zhari, Zakaria, Norfahana, Mohd, Khamsah S., Saeed, Mohammed A. A., Hassan, Loiy E. A., Shafaei Darestani, Armaghan, Al-Suede, Fouad S. R., Memon, Abdul H., and Ismail, Zhari

Abstract

Zakaria, N., Mohd, K. S., Saeed, M. A. A., Hassan, L. E. A., Shafaei, A., Al-Suede, F. S. R., ... Ismail, Z. (2020). Anti-uterine fibroid effect of standardized labisia pumila var. Alata extracts in vitro and in human uterine fibroid cancer xenograft model. Asian Pacific Journal of Cancer Prevention, 21(4), 943-951. https://doi.org/10.31557/APJCP.2020.21.4.943

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