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1,210 results on '"Meltzer, Paul S"'

3. Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

Author

Sun, Yilun, Baechler, Simone A., Zhang, Xiaohu, Kumar, Suresh, Factor, Valentina M., Arakawa, Yasuhiro, Chau, Cindy H., Okamoto, Kanako, Parikh, Anup, Walker, Bob, Su, Yijun P., Chen, Jiji, Ting, Tabitha, Huang, Shar-yin N., Beck, Erin, Itkin, Zina, McKnight, Crystal, Xie, Changqing, Roper, Nitin, Nijhawan, Deepak, Figg, William Douglas, Meltzer, Paul S., Yang, James C., Thomas, Craig J., and Pommier, Yves

Published
2023
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4. Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.

Author

Au, Wei-Chun, Zhang, Tianyi, Mishra, Prashant K, Eisenstatt, Jessica R, Walker, Robert L, Ocampo, Josefina, Dawson, Anthony, Warren, Jack, Costanzo, Michael, Baryshnikova, Anastasia, Flick, Karin, Clark, David J, Meltzer, Paul S, Baker, Richard E, Myers, Chad, Boone, Charles, Kaiser, Peter, and Basrai, Munira A

Subjects
Centromere, Saccharomyces cerevisiae, Chromosomal Instability, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, F-Box Proteins, Cell Cycle Proteins, DNA-Binding Proteins, Saccharomyces cerevisiae Proteins, Chromosomal Proteins, Non-Histone, Chromosome Segregation, Ubiquitination, Proteolysis, Protein Domains, Chromosomal Proteins, Non-Histone, Genetics, Developmental Biology
Abstract

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cells. Overexpression and mislocalization of CENP-A has been observed in many cancers and this correlates with increased invasiveness and poor prognosis. Yet genes that regulate CENP-A levels and localization under physiological conditions have not been defined. In this study we used a genome-wide genetic screen to identify essential genes required for Cse4 homeostasis to prevent its mislocalization for chromosomal stability. We show that two Skp, Cullin, F-box (SCF) ubiquitin ligases with the evolutionarily conserved F-box proteins Met30 and Cdc4 interact and cooperatively regulate proteolysis of endogenous Cse4 and prevent its mislocalization for faithful chromosome segregation under physiological conditions. The interaction of Met30 with Cdc4 is independent of the D domain, which is essential for their homodimerization and ubiquitination of other substrates. The requirement for both Cdc4 and Met30 for ubiquitination is specifc for Cse4; and a common substrate for Cdc4 and Met30 has not previously been described. Met30 is necessary for the interaction between Cdc4 and Cse4, and defects in this interaction lead to stabilization and mislocalization of Cse4, which in turn contributes to CIN. We provide the first direct link between Cse4 mislocalization to defects in kinetochore structure and show that SCF-mediated proteolysis of Cse4 is a major mechanism that prevents stable maintenance of Cse4 at non-centromeric regions, thus ensuring faithful chromosome segregation. In summary, we have identified essential pathways that regulate cellular levels of endogenous Cse4 and shown that proteolysis of Cse4 by SCF-Met30/Cdc4 prevents mislocalization and CIN in unperturbed cells.

Published
2020

5. The DNA methyltransferase inhibitor 5-aza-4’-thio-2’-deoxycytidine induces C>G transversions and acute lymphoid leukemia development

Author

Bertoli, Ryan M., primary, Chung, Yang Jo, additional, Difilippantonio, Michael J., additional, Wokasch, Anthony, additional, Marasco, Madison R.B., additional, Klimaszewski, Haley, additional, Gammell, Susannah, additional, Zhu, Yuelin J., additional, Walker, Robert L., additional, Cao, Dengchao, additional, Khanna, Ajay, additional, Walter, Matthew J., additional, Doroshow, James H., additional, Meltzer, Paul S., additional, and Aplan, Peter D., additional

Published
2024
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7. A chromatin structure based model accurately predicts DNA replication timing in human cells

Author

Gindin, Yevgeniy, Valenzuela, Manuel S., Aladjem, Mirit I., Meltzer, Paul S., and Bilke, Sven

Subjects
Quantitative Biology - Subcellular Processes, Quantitative Biology - Genomics
Abstract

The metazoan genome is replicated in precise cell lineage specific temporal order. However, the mechanism controlling this orchestrated process is poorly understood as no molecular mechanisms have been identified that actively regulate the firing sequence of genome replication. Here we develop a mechanistic model of genome replication capable of predicting, with accuracy rivaling experimental repeats, observed empirical replication timing program in humans. In our model, replication is initiated in an uncoordinated (time-stochastic) manner at well-defined sites. The model contains, in addition to the choice of the genomic landmark that localizes initiation, only a single adjustable parameter of direct biological relevance: the number of replication forks. We find that DNase hypersensitive sites are optimal and independent determinants of DNA replication initiation. We demonstrate that the DNA replication timing program in human cells is a robust emergent phenomenon that, by its very nature, does not require a regulatory mechanism determining a proper replication initiation firing sequence.

Published
2014

8. Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Author

van Wietmarschen, Niek, Sridharan, Sriram, Nathan, William J., Tubbs, Anthony, Chan, Edmond M., Callen, Elsa, Wu, Wei, Belinky, Frida, Tripathi, Veenu, Wong, Nancy, Foster, Kyla, Noorbakhsh, Javad, Garimella, Kiran, Cruz-Migoni, Abimael, Sommers, Joshua A., Huang, Yongqing, Borah, Ashir A., Smith, Jonathan T., Kalfon, Jeremie, Kesten, Nikolas, Fugger, Kasper, Walker, Robert L., Dolzhenko, Egor, Eberle, Michael A., Hayward, Bruce E., Usdin, Karen, Freudenreich, Catherine H., Brosh, Jr, Robert M., West, Stephen C., McHugh, Peter J., Meltzer, Paul S., Bass, Adam J., and Nussenzweig, André

Published
2020
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14. Abstract 314: Intratumor genetic heterogeneity dictates metastatic subclones in stage II colon cancer

Author

Yaghoubi, Sanam, primary, Heselmeyer-Haddad, Kerstin, additional, Archilla, Ivan, additional, Parra, Carolina, additional, Wangsa, Darawalee, additional, Castellano, Giancarlo, additional, Lahoz, Sara, additional, Pablo-Fontecha, Veronica, additional, Hirsch, Daniela, additional, Chen, Wei-Dong, additional, Ried, Thomas, additional, Cuatrecasas, Miriam, additional, Meltzer, Paul S., additional, and Camps, Jordi, additional

Published
2023
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16. Data from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
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18. Supplementary Figure 1 from Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

Author

Killian, J. Keith, primary, Kim, Su Young, primary, Miettinen, Markku, primary, Smith, Carly, primary, Merino, Maria, primary, Tsokos, Maria, primary, Quezado, Martha, primary, Smith, William I., primary, Jahromi, Mona S., primary, Xekouki, Paraskevi, primary, Szarek, Eva, primary, Walker, Robert L., primary, Lasota, Jerzy, primary, Raffeld, Mark, primary, Klotzle, Brandy, primary, Wang, Zengfeng, primary, Jones, Laura, primary, Zhu, Yuelin, primary, Wang, Yonghong, primary, Waterfall, Joshua J., primary, O'Sullivan, Maureen J., primary, Bibikova, Marina, primary, Pacak, Karel, primary, Stratakis, Constantine, primary, Janeway, Katherine A., primary, Schiffman, Joshua D., primary, Fan, Jian-Bing, primary, Helman, Lee, primary, and Meltzer, Paul S., primary

Published
2023
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19. Data from Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

Author

Killian, J. Keith, primary, Kim, Su Young, primary, Miettinen, Markku, primary, Smith, Carly, primary, Merino, Maria, primary, Tsokos, Maria, primary, Quezado, Martha, primary, Smith, William I., primary, Jahromi, Mona S., primary, Xekouki, Paraskevi, primary, Szarek, Eva, primary, Walker, Robert L., primary, Lasota, Jerzy, primary, Raffeld, Mark, primary, Klotzle, Brandy, primary, Wang, Zengfeng, primary, Jones, Laura, primary, Zhu, Yuelin, primary, Wang, Yonghong, primary, Waterfall, Joshua J., primary, O'Sullivan, Maureen J., primary, Bibikova, Marina, primary, Pacak, Karel, primary, Stratakis, Constantine, primary, Janeway, Katherine A., primary, Schiffman, Joshua D., primary, Fan, Jian-Bing, primary, Helman, Lee, primary, and Meltzer, Paul S., primary

Published
2023
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20. Data from NUP98–PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function

Author

Gough, Sheryl M., primary, Lee, Fan, primary, Yang, Fan, primary, Walker, Robert L., primary, Zhu, Yeulin J., primary, Pineda, Marbin, primary, Onozawa, Masahiro, primary, Chung, Yang Jo, primary, Bilke, Sven, primary, Wagner, Elise K., primary, Denu, John M., primary, Ning, Yi, primary, Xu, Bowen, primary, Wang, Gang Greg, primary, Meltzer, Paul S., primary, and Aplan, Peter D., primary

Published
2023
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21. Supplementary Table 3 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
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22. Supplementary Table 2 from Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

Author

Killian, J. Keith, primary, Kim, Su Young, primary, Miettinen, Markku, primary, Smith, Carly, primary, Merino, Maria, primary, Tsokos, Maria, primary, Quezado, Martha, primary, Smith, William I., primary, Jahromi, Mona S., primary, Xekouki, Paraskevi, primary, Szarek, Eva, primary, Walker, Robert L., primary, Lasota, Jerzy, primary, Raffeld, Mark, primary, Klotzle, Brandy, primary, Wang, Zengfeng, primary, Jones, Laura, primary, Zhu, Yuelin, primary, Wang, Yonghong, primary, Waterfall, Joshua J., primary, O'Sullivan, Maureen J., primary, Bibikova, Marina, primary, Pacak, Karel, primary, Stratakis, Constantine, primary, Janeway, Katherine A., primary, Schiffman, Joshua D., primary, Fan, Jian-Bing, primary, Helman, Lee, primary, and Meltzer, Paul S., primary

Published
2023
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23. Supplementary Table 1 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
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25. Data from Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma

Author

Gartside, Michael G., primary, Chen, Huaibin, primary, Ibrahimi, Omar A., primary, Byron, Sara A., primary, Curtis, Amy V., primary, Wellens, Candice L., primary, Bengston, Ana, primary, Yudt, Laura M., primary, Eliseenkova, Anna V., primary, Ma, Jinghong, primary, Curtin, John A., primary, Hyder, Pilar, primary, Harper, Ursula L., primary, Riedesel, Erica, primary, Mann, Graham J., primary, Trent, Jeffrey M., primary, Bastian, Boris C., primary, Meltzer, Paul S., primary, Mohammadi, Moosa, primary, and Pollock, Pamela M., primary

Published
2023
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26. Supplementary Tables S1-S10 from NUP98–PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function

Author

Gough, Sheryl M., primary, Lee, Fan, primary, Yang, Fan, primary, Walker, Robert L., primary, Zhu, Yeulin J., primary, Pineda, Marbin, primary, Onozawa, Masahiro, primary, Chung, Yang Jo, primary, Bilke, Sven, primary, Wagner, Elise K., primary, Denu, John M., primary, Ning, Yi, primary, Xu, Bowen, primary, Wang, Gang Greg, primary, Meltzer, Paul S., primary, and Aplan, Peter D., primary

Published
2023
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27. Supplementary Data from Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma

Author

Gartside, Michael G., primary, Chen, Huaibin, primary, Ibrahimi, Omar A., primary, Byron, Sara A., primary, Curtis, Amy V., primary, Wellens, Candice L., primary, Bengston, Ana, primary, Yudt, Laura M., primary, Eliseenkova, Anna V., primary, Ma, Jinghong, primary, Curtin, John A., primary, Hyder, Pilar, primary, Harper, Ursula L., primary, Riedesel, Erica, primary, Mann, Graham J., primary, Trent, Jeffrey M., primary, Bastian, Boris C., primary, Meltzer, Paul S., primary, Mohammadi, Moosa, primary, and Pollock, Pamela M., primary

Published
2023
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28. Supplementary Table 6 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
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29. Supplementary Table 5 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
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30. Supplementary Figures 1 - 11 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
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31. Supplementary Table 2 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
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32. Supplementary Table 1 from Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

Author

Killian, J. Keith, primary, Kim, Su Young, primary, Miettinen, Markku, primary, Smith, Carly, primary, Merino, Maria, primary, Tsokos, Maria, primary, Quezado, Martha, primary, Smith, William I., primary, Jahromi, Mona S., primary, Xekouki, Paraskevi, primary, Szarek, Eva, primary, Walker, Robert L., primary, Lasota, Jerzy, primary, Raffeld, Mark, primary, Klotzle, Brandy, primary, Wang, Zengfeng, primary, Jones, Laura, primary, Zhu, Yuelin, primary, Wang, Yonghong, primary, Waterfall, Joshua J., primary, O'Sullivan, Maureen J., primary, Bibikova, Marina, primary, Pacak, Karel, primary, Stratakis, Constantine, primary, Janeway, Katherine A., primary, Schiffman, Joshua D., primary, Fan, Jian-Bing, primary, Helman, Lee, primary, and Meltzer, Paul S., primary

Published
2023
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33. Supplementary Methods and Figures from NUP98–PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function

Author

Gough, Sheryl M., primary, Lee, Fan, primary, Yang, Fan, primary, Walker, Robert L., primary, Zhu, Yeulin J., primary, Pineda, Marbin, primary, Onozawa, Masahiro, primary, Chung, Yang Jo, primary, Bilke, Sven, primary, Wagner, Elise K., primary, Denu, John M., primary, Ning, Yi, primary, Xu, Bowen, primary, Wang, Gang Greg, primary, Meltzer, Paul S., primary, and Aplan, Peter D., primary

Published
2023
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34. Supplementary Table 4 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
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36. Author Correction: Interaction between the microbiome and TP53 in human lung cancer

Author

Greathouse, K. Leigh, White, James R., Vargas, Ashely J., Bliskovsky, Valery V., Beck, Jessica A., von Muhlinen, Natalia, Polley, Eric C., Bowman, Elise D., Khan, Mohammed A., Robles, Ana I., Cooks, Tomer, Ryan, Bríd M., Padgett, Noah, Dzutsev, Amiran H., Trinchieri, Giorgio, Pineda, Marbin A., Bilke, Sven, Meltzer, Paul S., Hokenstad, Alexis N., Stickrod, Tricia M., Walther-Antonio, Marina R., Earl, Joshua P., Mell, Joshua C., Krol, Jaroslaw E., Balashov, Sergey V., Bhat, Archana S., Ehrlich, Garth D., Valm, Alex, Deming, Clayton, Conlan, Sean, Oh, Julia, Segre, Julie A., and Harris, Curtis C.

Published
2020
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37. Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

Author

Marie, Kerrie L., Sassano, Antonella, Yang, Howard H., Michalowski, Aleksandra M., Michael, Helen T., Guo, Theresa, Tsai, Yien Che, Weissman, Allan M., Lee, Maxwell P., Jenkins, Lisa M., Zaidi, M. Raza, Pérez-Guijarro, Eva, Day, Chi-Ping, Ylaya, Kris, Hewitt, Stephen M., Patel, Nimit L., Arnheiter, Heinz, Davis, Sean, Meltzer, Paul S., Merlino, Glenn, and Mishra, Pravin J.

Published
2020
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41. Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

Author

Morrow, James J, Bayles, Ian, Funnell, Alister P W, Miller, Tyler E, Saiakhova, Alina, Lizardo, Michael M, Bartels, Cynthia F, Kapteijn, Maaike Y, Hung, Stevephen, Mendoza, Arnulfo, Dhillon, Gursimran, Chee, Daniel R, Myers, Jay T, Allen, Frederick, Gambarotti, Marco, Righi, Alberto, DiFeo, Analisa, Rubin, Brian P, Huang, Alex Y, Meltzer, Paul S, Helman, Lee J, Picci, Piero, Versteeg, Henri H, Stamatoyannopoulos, John A, Khanna, Chand, and Scacheri, Peter C

Subjects
Osteosarcoma -- Development and progression -- Genetic aspects -- Research, Cancer metastasis -- Development and progression -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Metastasis results from a complex set of traits acquired by tumor cells, distinct from those necessary for tumorigenesis. Here, we investigate the contribution of enhancer elements to the metastatic phenotype of osteosarcoma. Through epigenomic profiling, we identify substantial differences in enhancer activity between primary and metastatic human tumors and between near isogenic pairs of highly lung metastatic and nonmetastatic osteosarcoma cell lines. We term these regions metastatic variant enhancer loci (Met-VELs). Met-VELs drive coordinated waves of gene expression during metastatic colonization of the lung. Met-VELs cluster nonrandomly in the genome, indicating that activity of these enhancers and expression of their associated gene targets are positively selected. As evidence of this causal association, osteosarcoma lung metastasis is inhibited by global interruptions of Met-VEL-associated gene expression via pharmacologic BET inhibition, by knockdown of AP-1 transcription factors that occupy Met-VELs, and by knockdown or functional inhibition of individual genes activated by Met-VELs, such as that encoding coagulation factor III/tissue factor (F3). We further show that genetic deletion of a single Met-VEL at the F3 locus blocks metastatic cell outgrowth in the lung. These findings indicate that Met-VELs and the genes they regulate play a functional role in metastasis and may be suitable targets for antimetastatic therapies., Author(s): James J Morrow [1, 2]; Ian Bayles [2]; Alister P W Funnell [3]; Tyler E Miller [1]; Alina Saiakhova [2]; Michael M Lizardo [4]; Cynthia F Bartels [2]; Maaike [...]

Published
2018
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42. ATP11B mediates platinum resistance in ovarian cancer

Author

Moreno-Smith, Myrthala, Haider, J.B., Meltzer, Paul S., Gonda, Tamas A., Mangala, Lingegowda S., Rupaimoole, Rajesha, Lu, Chunhua, Nagaraja, Archana S., Gharpure, Kshipra M., Kang, Yu, Rodriguez-Aguayo, Cristian, Vivas-Mejia, Pablo E., Zand, Behrouz, Schmandt, Rosemarie, Wang, Hua, Langley, Robert R., Jennings, Nicholas B., Ivan, Cristina, Coffin, Jeremy E., Armaiz, Guillermo N., Bottsford-Miller, Justin, Kim, Sang Bae, Halleck, Margaret S., Hendrix, Mary J.C., Bornman, William, Bar-Eli, Menashe, Lee, Ju-Seog, Siddik, Zahid H., Lopez-Berestein, Gabriel, and Sood, Anil K.

Subjects
Health care industry
Abstract

Original citation: J Clin Invest. 2013;123(5):2119-2130. https://doi.org/10.1172/JCI65425. Citation for this corrigendum: J Clin Invest. 2021;131(7):e149893. https://doi.org/10.1172/JCI149893. The Editors previously posted an Expression of Concern for this article regarding images in [...]

Published
2021
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45. Supplemental Table S1 from The NCI-60 Methylome and Its Integration into CellMiner

Author

Reinhold, William C., primary, Varma, Sudhir, primary, Sunshine, Margot, primary, Rajapakse, Vinodh, primary, Luna, Augustin, primary, Kohn, Kurt W., primary, Stevenson, Holly, primary, Wang, Yonghong, primary, Heyn, Holger, primary, Nogales, Vanesa, primary, Moran, Sebastian, primary, Goldstein, David J., primary, Doroshow, James H., primary, Meltzer, Paul S., primary, Esteller, Manel, primary, and Pommier, Yves, primary

Published
2023
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46. Supplementary Table S6 from Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL

Author

Goldberg, Liat, primary, Negi, Vijay, primary, Chung, Yang Jo, primary, Onozawa, Masahiro, primary, Zhu, Yuelin J., primary, Walker, Robert L., primary, Pierce, Rachel, primary, Patel, Daxesh P., primary, Krausz, Kristopher W., primary, Gonzalez, Frank J., primary, Goodell, Margaret A., primary, Rodriguez, Benjamin A.T., primary, Meltzer, Paul S., primary, and Aplan, Peter D., primary

Published
2023
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47. Supplemental Figure Legends from The NCI-60 Methylome and Its Integration into CellMiner

Author

Reinhold, William C., primary, Varma, Sudhir, primary, Sunshine, Margot, primary, Rajapakse, Vinodh, primary, Luna, Augustin, primary, Kohn, Kurt W., primary, Stevenson, Holly, primary, Wang, Yonghong, primary, Heyn, Holger, primary, Nogales, Vanesa, primary, Moran, Sebastian, primary, Goldstein, David J., primary, Doroshow, James H., primary, Meltzer, Paul S., primary, Esteller, Manel, primary, and Pommier, Yves, primary

Published
2023
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48. Supplementary Figures from Dynamics of Genome Alterations in Crohn's Disease–Associated Colorectal Carcinogenesis

Author

Hirsch, Daniela, primary, Wangsa, Darawalee, primary, Zhu, Yuelin J., primary, Hu, Yue, primary, Edelman, Daniel C., primary, Meltzer, Paul S., primary, Heselmeyer-Haddad, Kerstin, primary, Ott, Claudia, primary, Kienle, Peter, primary, Galata, Christian, primary, Horisberger, Karoline, primary, Ried, Thomas, primary, and Gaiser, Timo, primary

Published
2023
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49. Data from The NCI-60 Methylome and Its Integration into CellMiner

Author

Reinhold, William C., primary, Varma, Sudhir, primary, Sunshine, Margot, primary, Rajapakse, Vinodh, primary, Luna, Augustin, primary, Kohn, Kurt W., primary, Stevenson, Holly, primary, Wang, Yonghong, primary, Heyn, Holger, primary, Nogales, Vanesa, primary, Moran, Sebastian, primary, Goldstein, David J., primary, Doroshow, James H., primary, Meltzer, Paul S., primary, Esteller, Manel, primary, and Pommier, Yves, primary

Published
2023
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