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1. Association of Red Blood Cell Omega-3 Fatty Acids With MRI Markers and Cognitive Function in Midlife

Author

Satizabal, Claudia L, Himali, Jayandra Jung, Beiser, Alexa S, Ramachandran, Vasan, Melo van Lent, Debora, Himali, Dibya, Aparicio, Hugo J, Maillard, Pauline, DeCarli, Charles S, Harris, William S, and Seshadri, Sudha

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Vascular Cognitive Impairment/Dementia, Genetics, Biomedical Imaging, Alzheimer's Disease, Prevention, Aging, Brain Disorders, Acquired Cognitive Impairment, Alzheimer's Disease Related Dementias (ADRD), Complementary and Integrative Health, Cerebrovascular, Clinical Research, Behavioral and Social Science, Dementia, Neurodegenerative, Nutrition, 2.1 Biological and endogenous factors, 3.3 Nutrition and chemoprevention, Neurological, Middle Aged, Humans, Female, Aged, Male, Fatty Acids, Omega-3, Cross-Sectional Studies, Docosahexaenoic Acids, Eicosapentaenoic Acid, Cognition, Longitudinal Studies, Apolipoproteins E, Erythrocytes, Magnetic Resonance Imaging, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

Background and objectivesDiet may be a key contributor to brain health in midlife. In particular, omega-3 fatty acids have been related to better neurologic outcomes in older adults. However, studies focusing on midlife are lacking. We investigated the cross-sectional association of red blood cell (RBC) omega-3 fatty acid concentrations with MRI and cognitive markers of brain aging in a community-based sample of predominantly middle-aged adults and further explore effect modification by APOE genotype.MethodsWe included participants from the Third-Generation and Omni 2 cohorts of the Framingham Heart Study attending their second examination. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) concentrations were measured from RBC using gas chromatography, and the Omega-3 index was calculated as EPA + DHA. We used linear regression models to relate omega-3 fatty acid concentrations to brain MRI measures (i.e., total brain, total gray matter, hippocampal, and white matter hyperintensity volumes) and cognitive function (i.e., episodic memory, processing speed, executive function, and abstract reasoning) adjusting for potential confounders. We further tested for interactions between omega-3 fatty acid levels and APOE genotype (e4 carrier vs noncarrier) on MRI and cognitive outcomes.ResultsWe included 2,183 dementia-free and stroke-free participants (mean age of 46 years, 53% women, 22% APOE-e4 carriers). In multivariable models, higher Omega-3 index was associated with larger hippocampal volumes (standard deviation unit beta ±standard error; 0.003 ± 0.001, p = 0.013) and better abstract reasoning (0.17 ± 0.07, p = 0.013). Similar results were obtained for DHA or EPA concentrations individually. Stratification by APOE-e4 status showed associations between higher DHA concentrations or Omega-3 index and larger hippocampal volumes in APOE-e4 noncarriers, whereas higher EPA concentrations were related to better abstract reasoning in APOE-e4 carriers. Finally, higher levels of all omega-3 predictors were related to lower white matter hyperintensity burden but only in APOE-e4 carriers.DiscussionOur results, albeit exploratory, suggest that higher omega-3 fatty acid concentrations are related to better brain structure and cognitive function in a predominantly middle-aged cohort free of clinical dementia. These associations differed by APOE genotype, suggesting potentially different metabolic patterns by APOE status. Additional studies in middle-aged populations are warranted to confirm these findings.

Published
2022

2. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Author

O’Keefe, James H., Tintle, Nathan L., Harris, William S., O’Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu (Amelia), Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W.M. Monique, Boer, Jolanda M.A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush

Published
2024
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3. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.

Author

Babulal, Ganesh M, Quiroz, Yakeel T, Albensi, Benedict C, Arenaza-Urquijo, Eider, Astell, Arlene J, Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L, Brickman, Adam M, Chételat, Gaël, Ciro, Carrie, Cohen, Ann D, Dilworth-Anderson, Peggye, Dodge, Hiroko H, Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N, Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R, Head, Elizabeth, Hendrix, James A, Hofer, Scott M, Johnson, Leigh A, Jutten, Roos, Kilborn, Kerry, Lanctôt, Krista L, Manly, Jennifer J, Martins, Ralph N, Mielke, Michelle M, Morris, Martha Clare, Murray, Melissa E, Oh, Esther S, Parra, Mario A, Rissman, Robert A, Roe, Catherine M, Santos, Octavio A, Scarmeas, Nikolaos, Schneider, Lon S, Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M, Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Terrera, Graciela Muniz, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M, Zetterberg, Henrik, O'Bryant, Sid E, and International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association

Subjects
International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Humans, Alzheimer Disease, Biomedical Research, Aged, Continental Population Groups, Ethnic Groups, Healthcare Disparities, Biomarkers, Alzheimer's disease, Alzheimer's related dementias, Diversity, Ethnicity, Ethnoracial, Translational, Underserved, Geriatrics, Clinical Sciences, Neurosciences
Abstract

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise "state-of-the-science" report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.

Published
2019

4. Omega-3 Blood Levels and Stroke Risk : A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Author

O'Keefe, James H., Tintle, Nathan L., Harris, William S., O'Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Sørensen Bork, Christian, Berg Schmidt, Erik, Krogh Venø, Stine, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Rudholm Feldreich, Tobias, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W. M. Monique, Boer, Jolanda M. A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., Mozaffarian, Dariush, O'Keefe, James H., Tintle, Nathan L., Harris, William S., O'Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Sørensen Bork, Christian, Berg Schmidt, Erik, Krogh Venø, Stine, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Rudholm Feldreich, Tobias, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W. M. Monique, Boer, Jolanda M. A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush

Abstract

BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome. RESULTS: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76–0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74–0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81–0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78–0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD. CONCLUSIONS: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.

Published
2024
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5. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, O'Keefe, James H, Tintle, Nathan L, Harris, William S, O'Keefe, Evan L, Sala-Vila, Aleix, Attia, John, Garg, G Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G, Geleijnse, Johanna M, Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R, Longstreth, William T, Manson, JoAnn E, Mora, Samia, Cook, Nancy R, Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V, Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M Kamran, Tanaka, Toshiko, Das, Jayanta K, Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W M Monique, Boer, Jolanda M A, Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S, Lemaitre, Rozenn N, Mozaffarian, Dariush, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, O'Keefe, James H, Tintle, Nathan L, Harris, William S, O'Keefe, Evan L, Sala-Vila, Aleix, Attia, John, Garg, G Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G, Geleijnse, Johanna M, Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R, Longstreth, William T, Manson, JoAnn E, Mora, Samia, Cook, Nancy R, Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V, Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M Kamran, Tanaka, Toshiko, Das, Jayanta K, Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W M Monique, Boer, Jolanda M A, Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S, Lemaitre, Rozenn N, and Mozaffarian, Dariush

Published
2024

6. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Author

Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chételat, Gaël, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko H., Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctôt, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle M., Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R., Stern, Yaakov, Strydom, Andre, Tang, Yi, Terrera, Graciela Muniz, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, and O'Bryant, Sid E.

Published
2019
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7. Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

Author

van der Lee, Sven J., Teunissen, Charlotte E., Pool, René, Shipley, Martin J., Teumer, Alexander, Chouraki, Vincent, Melo van Lent, Debora, Tynkkynen, Juho, Fischer, Krista, Hernesniemi, Jussi, Haller, Toomas, Singh-Manoux, Archana, Verhoeven, Aswin, Willemsen, Gonneke, de Leeuw, Francisca A., Wagner, Holger, van Dongen, Jenny, Hertel, Johannes, Budde, Kathrin, Willems van Dijk, Ko, Weinhold, Leonie, Ikram, M. Arfan, Pietzner, Maik, Perola, Markus, Wagner, Michael, Friedrich, Nele, Slagboom, P. Eline, Scheltens, Philip, Yang, Qiong, Gertzen, Robert E., Egert, Sarah, Li, Shuo, Hankemeier, Thomas, van Beijsterveldt, Catharina E.M., Vasan, Ramachandran S., Maier, Wolfgang, Peeters, Carel F.W., Jörgen Grabe, Hans, Ramirez, Alfredo, Seshadri, Sudha, Metspalu, Andres, Kivimäki, Mika, Salomaa, Veikko, Demirkan, Ayşe, Boomsma, Dorret I., van der Flier, Wiesje M., Amin, Najaf, and van Duijn, Cornelia M.

Published
2018
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8. Nonalcoholic fatty liver disease, liver fibrosis, and structural brain imaging: The Cross‐Cohort Collaboration

Author

Weinstein, Galit, primary, O'Donnell, Adrienne, additional, Frenzel, Stefan, additional, Xiao, Tian, additional, Yaqub, Amber, additional, Yilmaz, Pinar, additional, de Knegt, Robert J., additional, Maestre, Gladys E., additional, Melo van Lent, Debora, additional, Long, Michelle, additional, Gireud‐Goss, Monica, additional, Ittermann, Till, additional, Frost, Fabian, additional, Bülow, Robin, additional, Vasan, Ramachandran S., additional, Grabe, Hans J., additional, Ikram, M. Arfan, additional, Beiser, Alexa S., additional, and Seshadri, Sudha, additional

Published
2023
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9. Association between dietary inflammatory index score and incident dementia: results from the Framingham heart Study offspring cohort

Author

Melo van Lent, Debora, primary, Gokingco Mesa, Hannah, additional, Short, Meghan I., additional, Gonzales, Mitzi M, additional, Aparicio, Hugo J, additional, Salinas, Joel, additional, Yuan, Changzheng, additional, Jacques, Paul F, additional, Beiser, Alexa, additional, Seshadri, Sudha, additional, Jacob, Mini E, additional, and Himali, Jayandra J, additional

Published
2023
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10. Association of the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet With the Risk of Dementia

Author

Chen, Hui, primary, Dhana, Klodian, additional, Huang, Yuhui, additional, Huang, Liyan, additional, Tao, Yang, additional, Liu, Xiaoran, additional, Melo van Lent, Debora, additional, Zheng, Yan, additional, Ascherio, Alberto, additional, Willett, Walter, additional, and Yuan, Changzheng, additional

Published
2023
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11. Nonalcoholic fatty liver disease, liver fibrosis, and structural brain imaging: The Cross‐Cohort Collaboration.

Author

Weinstein, Galit, O'Donnell, Adrienne, Frenzel, Stefan, Xiao, Tian, Yaqub, Amber, Yilmaz, Pinar, de Knegt, Robert J., Maestre, Gladys E., Melo van Lent, Debora, Long, Michelle, Gireud‐Goss, Monica, Ittermann, Till, Frost, Fabian, Bülow, Robin, Vasan, Ramachandran S., Grabe, Hans J., Ikram, M. Arfan, Beiser, Alexa S., and Seshadri, Sudha

Subjects
HEPATIC fibrosis, NON-alcoholic fatty liver disease, BRAIN imaging, GRAY matter (Nerve tissue), WHITE matter (Nerve tissue)
Abstract

Background and purpose: Prior studies reported conflicting findings regarding the association of nonalcoholic fatty liver disease (NAFLD) and liver fibrosis with measures of brain health. We examined whether NAFLD and liver fibrosis are associated with structural brain imaging measures in middle‐ and old‐age adults. Methods: In this cross‐sectional study among dementia‐ and stroke‐free individuals, data were pooled from the Offspring and Third Generation cohorts of the Framingham Heart Study (FHS), the Rotterdam Study (RS), and the Study of Health in Pomerania. NAFLD was assessed through abdominal imaging. Transient hepatic elastography (FibroScan) was used to assess liver fibrosis in FHS and RS. Linear regression models were used to explore the relation of NAFLD and liver fibrosis with brain volumes, including total brain, gray matter, hippocampus, and white matter hyperintensities, adjusting for potential confounders. Results were combined using fixed effects meta‐analysis. Results: In total, 5660 and 3022 individuals were included for NAFLD and liver fibrosis analyses, respectively. NAFLD was associated with smaller volumes of total brain (β = −3.5, 95% confidence interval [CI] = −5.4 to −1.7), total gray matter (β = −1.9, 95% CI = −3.4 to −0.3), and total cortical gray matter (β = −1.9, 95% CI = −3.7 to −0.01). In addition, liver fibrosis (defined as liver stiffness measure ≥8.2 kPa) was related to smaller total brain volumes (β = −7.3, 95% CI = −11.1 to −3.5). Heterogeneity between studies was low. Conclusions: NAFLD and liver fibrosis may be directly related to brain aging. Larger and prospective studies are warranted to validate these findings and identify liver‐related preventive strategies for neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old

Author

Melo van Lent, Debora, primary, Egert, Sarah, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Weinhold, Leonie, additional, Wagner-Thelen, Holger, additional, Stoffel-Wagner, Birgit, additional, Bickel, Horst, additional, Wiese, Birgitt, additional, Weyerer, Siegfried, additional, Pentzek, Michael, additional, Jessen, Frank, additional, Schmid, Matthias, additional, Maier, Wolfgang, additional, Scherer, Martin, additional, Riedel-Heller, Steffi G., additional, Ramirez, Alfredo, additional, and Wagner, Michael, additional

Published
2022
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15. Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis

Author

Frenzel, Stefan, primary, Bis, Joshua C., additional, Gudmundsson, Elias F., additional, O’Donnell, Adrienne, additional, Simino, Jeannette, additional, Yaqub, Amber, additional, Bartz, Traci M., additional, Brusselle, Guy G. O., additional, Bülow, Robin, additional, DeCarli, Charles S., additional, Ewert, Ralf, additional, Gharib, Sina A., additional, Ghosh, Saptaparni, additional, Gireud-Goss, Monica, additional, Gottesman, Rebecca F., additional, Ikram, M. Arfan, additional, Knopman, David S., additional, Launer, Lenore J., additional, London, Stephanie J., additional, Longstreth, W.T., additional, Lopez, Oscar L., additional, Melo van Lent, Debora, additional, O’Connor, George, additional, Satizabal, Claudia L., additional, Shrestha, Srishti, additional, Sigurdsson, Sigurdur, additional, Stubbe, Beate, additional, Talluri, Rajesh, additional, Vasan, Ramachandran S., additional, Vernooij, Meike W., additional, Völzke, Henry, additional, Wiggins, Kerri L., additional, Yu, Bing, additional, Beiser, Alexa S., additional, Gudnason, Vilmundur, additional, Mosley, Thomas, additional, Psaty, Bruce M., additional, Wolters, Frank J., additional, Grabe, Hans J., additional, and Seshadri, Sudha, additional

Published
2022
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18. Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.

Author

Frenzel, Stefan, Frenzel, Stefan, Bis, Joshua C, Gudmundsson, Elias F, O'Donnell, Adrienne, Simino, Jeannette, Yaqub, Amber, Bartz, Traci M, Brusselle, Guy GO, Bülow, Robin, DeCarli, Charles S, Ewert, Ralf, Gharib, Sina A, Ghosh, Saptaparni, Gireud-Goss, Monica, Gottesman, Rebecca F, Ikram, M Arfan, Knopman, David S, Launer, Lenore J, London, Stephanie J, Longstreth, WT, Lopez, Oscar L, Melo van Lent, Debora, O'Connor, George, Satizabal, Claudia L, Shrestha, Srishti, Sigurdsson, Sigurdur, Stubbe, Beate, Talluri, Rajesh, Vasan, Ramachandran S, Vernooij, Meike W, Völzke, Henry, Wiggins, Kerri L, Yu, Bing, Beiser, Alexa S, Gudnason, Vilmundur, Mosley, Thomas, Psaty, Bruce M, Wolters, Frank J, Grabe, Hans J, Seshadri, Sudha, Frenzel, Stefan, Frenzel, Stefan, Bis, Joshua C, Gudmundsson, Elias F, O'Donnell, Adrienne, Simino, Jeannette, Yaqub, Amber, Bartz, Traci M, Brusselle, Guy GO, Bülow, Robin, DeCarli, Charles S, Ewert, Ralf, Gharib, Sina A, Ghosh, Saptaparni, Gireud-Goss, Monica, Gottesman, Rebecca F, Ikram, M Arfan, Knopman, David S, Launer, Lenore J, London, Stephanie J, Longstreth, WT, Lopez, Oscar L, Melo van Lent, Debora, O'Connor, George, Satizabal, Claudia L, Shrestha, Srishti, Sigurdsson, Sigurdur, Stubbe, Beate, Talluri, Rajesh, Vasan, Ramachandran S, Vernooij, Meike W, Völzke, Henry, Wiggins, Kerri L, Yu, Bing, Beiser, Alexa S, Gudnason, Vilmundur, Mosley, Thomas, Psaty, Bruce M, Wolters, Frank J, Grabe, Hans J, and Seshadri, Sudha

Abstract

BackgroundPrevious studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.ObjectiveTo study the cross-sectional associations of pulmonary function with structural brain variables.MethodsData from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses.ResultsFEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume.ConclusionIn cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.

Published
2022

19. Association of Red Blood Cell Omega-3 Fatty Acids With MRI Markers and Cognitive Function in Midlife: The Framingham Heart Study.

Author

Satizabal, Claudia L, Satizabal, Claudia L, Himali, Jayandra Jung, Beiser, Alexa S, Ramachandran, Vasan, Melo van Lent, Debora, Himali, Dibya, Aparicio, Hugo J, Maillard, Pauline, DeCarli, Charles S, Harris, William, Seshadri, Sudha, Satizabal, Claudia L, Satizabal, Claudia L, Himali, Jayandra Jung, Beiser, Alexa S, Ramachandran, Vasan, Melo van Lent, Debora, Himali, Dibya, Aparicio, Hugo J, Maillard, Pauline, DeCarli, Charles S, Harris, William, and Seshadri, Sudha

Abstract

Background and objectivesDiet may be a key contributor to brain health in midlife. In particular, Omega-3 fatty acids have been related to better neurological outcomes in older adults. However, studies focusing on midlife are lacking. We investigated the cross-sectional association of red blood cell (RBC) Omega-3 fatty acid concentrations with MRI and cognitive markers of brain aging in a community-based sample of predominantly middle-aged adults, and further explore effect modification by APOE genotype.MethodsWe included participants from the Third-Generation and Omni 2 cohorts of the Framingham Heart Study attending their second examination. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) concentrations were measured from RBC using gas chromatography, and the Omega-3 index was calculated as EPA + DHA. We used linear regression models to relate Omega-3 fatty acid concentrations to brain MRI measures (i.e., total brain, total gray matter, hippocampal, and white matter hyperintensity volumes) and cognitive function (i.e., episodic memory, processing speed, executive function, and abstract reasoning) adjusting for potential confounders. We further tested for interactions between omega-3 fatty acid levels and APOE genotype (e4 carrier vs. non-carrier) on MRI and cognitive outcomes.ResultsWe included 2,183 dementia- and stroke-free participants (mean age 46 years, 53% women, 22% APOE-e4 carriers). In multivariable models, higher Omega-3 index was associated with larger hippocampal volumes (standard deviation unit beta ±standard error; 0.003 ±0.001, p=0.04), and better abstract reasoning (0.17 ±0.07, p=0.013). Similar results were obtained for DHA or EPA concentrations individually. Stratification by APOE-e4 status showed associations between higher DHA concentrations or Omega-3 index and larger hippocampal volumes in APOE-e4 non-carriers, whereas higher EPA concentrations were related to better abstract reasoning in APOE-e4 carriers. Finally, higher levels of

Published
2022

20. Associations of Pulmonary Function with MRI Brain Volumes:A Coordinated Multi-Study Analysis

Author

Frenzel, Stefan, Bis, Joshua C., Gudmundsson, Elias F., O'Donnell, Adrienne, Simino, Jeannette, Yaqub, Amber, Bartz, Traci M., Brusselle, Guy G.O., Bülow, Robin, DeCarli, Charles S., Ewert, Ralf, Gharib, Sina A., Ghosh, Saptaparni, Gireud-Goss, Monica, Gottesman, Rebecca F., Ikram, M. Arfan, Knopman, David S., Launer, Lenore J., London, Stephanie J., Longstreth, W. T., Lopez, Oscar L., Melo van Lent, Debora, O'Connor, George, Satizabal, Claudia L., Shrestha, Srishti, Sigurdsson, Sigurdur, Stubbe, Beate, Talluri, Rajesh, Vasan, Ramachandran S., Vernooij, Meike W., Völzke, Henry, Wiggins, Kerri L., Yu, Bing, Beiser, Alexa S., Gudnason, Vilmundur, Mosley, Thomas, Psaty, Bruce M., Wolters, Frank J., Grabe, Hans J., Seshadri, Sudha, Frenzel, Stefan, Bis, Joshua C., Gudmundsson, Elias F., O'Donnell, Adrienne, Simino, Jeannette, Yaqub, Amber, Bartz, Traci M., Brusselle, Guy G.O., Bülow, Robin, DeCarli, Charles S., Ewert, Ralf, Gharib, Sina A., Ghosh, Saptaparni, Gireud-Goss, Monica, Gottesman, Rebecca F., Ikram, M. Arfan, Knopman, David S., Launer, Lenore J., London, Stephanie J., Longstreth, W. T., Lopez, Oscar L., Melo van Lent, Debora, O'Connor, George, Satizabal, Claudia L., Shrestha, Srishti, Sigurdsson, Sigurdur, Stubbe, Beate, Talluri, Rajesh, Vasan, Ramachandran S., Vernooij, Meike W., Völzke, Henry, Wiggins, Kerri L., Yu, Bing, Beiser, Alexa S., Gudnason, Vilmundur, Mosley, Thomas, Psaty, Bruce M., Wolters, Frank J., Grabe, Hans J., and Seshadri, Sudha

Abstract

BACKGROUND: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent. OBJECTIVE: To study the cross-sectional associations of pulmonary function with structural brain variables. METHODS: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses. RESULTS: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume. CONCLUSION: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.

Published
2022

21. Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort*

Author

Melo Van Lent, Debora, primary, Gokingco, Hannah, additional, Short, Meghan I., additional, Yuan, Changzheng, additional, Jacques, Paul F., additional, Romero, José R., additional, DeCarli, Charles S., additional, Beiser, Alexa S., additional, Seshadri, Sudha, additional, Himali, Jayandra J., additional, and Jacob, Mini E., additional

Published
2022
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23. Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort*.

Author

Melo Van Lent, Debora, Gokingco, Hannah, Short, Meghan I., Yuan, Changzheng, Jacques, Paul F., Romero, José R., DeCarli, Charles S., Beiser, Alexa S., Seshadri, Sudha, Himali, Jayandra J., and Jacob, Mini E.

Abstract

Introduction: We investigated cross‐sectional associations between the Dietary Inflammatory Index (DII) and measures of brain volume and cerebral small vessel disease among participants of the Framingham Heart Study Offspring cohort. Methods: A total of 1897 participants (mean ± standard deviation, age 62±9) completed Food Frequency Questionnaires and brain magnetic resonance imaging (MRI). Results: Higher (pro‐inflammatory) DII scores, averaged across a maximum of three time points, were associated with smaller total brain volume (beta ± standard error: –0.16 ± 0.03; P <.0001) after adjustment for demographic, clinical, and lifestyle covariates. In addition, higher DII scores were associated with smaller total gray matter volume (–0.08 ± 0.03; P =.003) and larger lateral ventricular volume (0.04 ± 0.02; P =.03). No associations were observed with other brain MRI measures. Discussion: Our findings showed associations between higher DII scores and global brain MRI measures. As we are one of the first groups to report on the associations between higher DII scores and brain volume, replication is needed to confirm our findings. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Low Serum Vitamin D Status Is Associated with Incident Alzheimer's Dementia in the Oldest Old.

Author

Melo van Lent, Debora, Egert, Sarah, Wolfsgruber, Steffen, Kleineidam, Luca, Weinhold, Leonie, Wagner-Thelen, Holger, Stoffel-Wagner, Birgit, Bickel, Horst, Wiese, Birgitt, Weyerer, Siegfried, Pentzek, Michael, Jessen, Frank, Schmid, Matthias, Maier, Wolfgang, Scherer, Martin, Riedel-Heller, Steffi G., Ramirez, Alfredo, and Wagner, Michael

Abstract

Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer's dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Personalized nutrition for dementia prevention

Author

Samieri, Cécilia, primary, Yassine, Hussein N., additional, Melo van Lent, Debora, additional, Lefèvre‐Arbogast, Sophie, additional, van de Rest, Ondine, additional, Bowman, Gene L., additional, and Scarmeas, Nikolaos, additional

Published
2021
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26. Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study

Author

Melo van Lent, Debora, primary, O’Donnell, Adrienne, additional, Beiser, Alexa S., additional, Vasan, Ramachandran S., additional, DeCarli, Charles S., additional, Scarmeas, Nikolaos, additional, Wagner, Michael, additional, Jacques, Paul F., additional, Seshadri, Sudha, additional, Himali, Jayandra J., additional, and Pase, Matthew P., additional

Published
2021
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27. Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old

Author

Melo van Lent, Debora, Egert, Sarah, Wolfsgruber, Steffen, Kleineidam, Luca, Weinhold, Leonie, Wagner-Thelen, Holger, Maier, Wolfgang, Jessen, Frank, Ramirez, Alfredo, Schmid, Matthias, Scherer, Martin, Riedel-Heller, Steffi G., Wagner, Michael, Melo van Lent, Debora, Egert, Sarah, Wolfsgruber, Steffen, Kleineidam, Luca, Weinhold, Leonie, Wagner-Thelen, Holger, Maier, Wolfgang, Jessen, Frank, Ramirez, Alfredo, Schmid, Matthias, Scherer, Martin, Riedel-Heller, Steffi G., and Wagner, Michael

Abstract

Background. Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) may have different effects on cognitive health due to their anti- or pro-inflammatory properties. Methods. We aimed to prospectively examine the relationships between n-3 and n-6 PUFA contents in serum phospholipids with incident all-cause dementia and Alzheimer's disease dementia (AD). We included 1264 non-demented participants aged 84 +/- 3 years from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) multicenter-cohort study. We investigated whether fatty acid concentrations in serum phospholipids, especially eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA), were associated with risk of incident all-cause dementia and AD. Results. During the follow-up window of seven years, 233 participants developed dementia. Higher concentrations of EPA were associated with a lower incidence of AD (hazard ratio (HR) 0.76 (95% CI 0.63; 0.93)). We also observed that higher concentrations of EPA were associated with a decreased risk for all-cause dementia (HR 0.76 (95% CI 0.61; 0.94)) and AD (HR 0.66 (95% CI 0.51; 0.85)) among apolipoprotein E epsilon 4 (APOE epsilon 4) non-carriers but not among APOE epsilon 4 carriers. No other fatty acids were significantly associated with AD or dementia. Conclusions. Higher concentrations of EPA were associated with a lower risk of incident AD. This further supports a beneficial role of n-3 PUFAs for cognitive health in old age.

Published
2021

28. Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

Author

Ballarini, Tommaso, Melo van Lent, Debora, Brunner, Julia, Schröder, Alina, Wolfsgruber, Steffen, Altenstein, Slawek, Brosseron, Frederic, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Duzel, Emrah, Ertl-Wagner, Birgit, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Glanz, Wenzel, Hauser, Dietmar, Haynes, John Dylan, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline Danielle, Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Priller, Josef, Ramirez, Alfredo, Rauchmann, Boris-Stephan, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Vukovich, Ruth, Wiltfang, Jens, Jessen, Frank, Wagner, Michael, Ballarini, Tommaso, Melo van Lent, Debora, Brunner, Julia, Schröder, Alina, Wolfsgruber, Steffen, Altenstein, Slawek, Brosseron, Frederic, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Duzel, Emrah, Ertl-Wagner, Birgit, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Glanz, Wenzel, Hauser, Dietmar, Haynes, John Dylan, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline Danielle, Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Priller, Josef, Ramirez, Alfredo, Rauchmann, Boris-Stephan, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Vukovich, Ruth, Wiltfang, Jens, Jessen, Frank, and Wagner, Michael

Published
2021

29. Personalized nutrition for dementia prevention.

Author

Samieri, Cécilia, Yassine, Hussein N., Melo van Lent, Debora, Lefèvre‐Arbogast, Sophie, van de Rest, Ondine, Bowman, Gene L., and Scarmeas, Nikolaos

Abstract

The role of nutrition has been investigated for decades under the assumption of one‐size‐fits‐all. Yet there is heterogeneity in metabolic and neurobiological responses to diet. Thus a more personalized approach may better fit biological reality and have increased efficacy to prevent dementia. Personalized nutrition builds on the food exposome, defined as the history of diet‐related exposures over the lifetime, and on its interactions with the genome and other biological characteristics (eg, metabolism, the microbiome) to shape health. We review current advances of personalized nutrition in dementia research. We discuss key questions, success milestones, and future roadmap from observational epidemiology to clinical studies through basic science. A personalized nutrition approach based on the best prescription for the most appropriate target population in the most relevant time‐window has the potential to strengthen dementia‐prevention efforts. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Associations of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet with cardiac remodelling in the community: the Framingham Heart Study

Author

Walker, Maura E., primary, O’Donnell, Adrienne A., additional, Himali, Jayandra J., additional, Rajendran, Iniya, additional, Melo van Lent, Debora, additional, Ataklte, Feven, additional, Jacques, Paul F., additional, Beiser, Alexa S., additional, Seshadri, Sudha, additional, Vasan, Ramachandran S., additional, and Xanthakis, Vanessa, additional

Published
2021
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31. Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer’s Dementia in the Oldest Old

Author

Melo van Lent, Debora, primary, Egert, Sarah, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Weinhold, Leonie, additional, Wagner-Thelen, Holger, additional, Maier, Wolfgang, additional, Jessen, Frank, additional, Ramirez, Alfredo, additional, Schmid, Matthias, additional, Scherer, Martin, additional, Riedel-Heller, Steffi G., additional, and Wagner, Michael, additional

Published
2021
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32. Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Author

Maretzke, Friederike, primary, Bechthold, Angela, additional, Egert, Sarah, additional, Ernst, Jana B., additional, Melo van Lent, Debora, additional, Pilz, Stefan, additional, Reichrath, Jörg, additional, Stangl, Gabriele I., additional, Stehle, Peter, additional, Volkert, Dorothee, additional, Wagner, Michael, additional, Waizenegger, Julia, additional, Zittermann, Armin, additional, and Linseisen, Jakob, additional

Published
2020
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33. P3-584: JOINT TRAJECTORIES OF COGNITIVE DECLINE AND GAIT SLOWING IN MEXICAN AMERICAN AND EUROPEAN AMERICAN OLDER ADULTS: THE SAN ANTONIO LONGITUDINAL STUDY OF AGING (SALSA)

Author

Gonzales, Mitzi, primary, Wang, Chen-Pin, additional, Jacob, Mini E., additional, MacCarthy, Daniel, additional, Satizabal, Claudia L., additional, Vasquez, Eliana A., additional, Melo van Lent, Debora, additional, Seshadri, Sudha, additional, and Hazuda, Helen, additional

Published
2019
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36. Abstract MP39: Association of MIND Diet Adherence With Brain Volume, Silent Brain Infarcts and Brain Atrophy in the Framingham Heart Study

Author

Melo van Lent, Debora, primary, O’Donnell, Adrienne, additional, Jacques, Paul, additional, DeCarli, Charles, additional, Wagner, Michael, additional, Beisler, Alexa S., additional, Ramachandran, Vasan, additional, Seshadri, Sudha, additional, Himali, Jayandra J., additional, and Pase, Matthew, additional

Published
2019
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39. Prospective Associations between Single Foods, Alzheimer’s Dementia and Memory Decline in the Elderly

Author

Fischer, Karina, primary, Melo van Lent, Debora, additional, Wolfsgruber, Steffen, additional, Weinhold, Leonie, additional, Kleineidam, Luca, additional, Bickel, Horst, additional, Scherer, Martin, additional, Eisele, Marion, additional, van den Bussche, Hendrik, additional, Wiese, Birgitt, additional, König, Hans-Helmut, additional, Weyerer, Siegfried, additional, Pentzek, Michael, additional, Röhr, Susanne, additional, Maier, Wolfgang, additional, Jessen, Frank, additional, Schmid, Matthias, additional, Riedel-Heller, Steffi, additional, and Wagner, Michael, additional

Published
2018
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47. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Author

Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chetelat, Gael, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko, Dreux, Simone, Edland, Steven D., Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctôt, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle, Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R., Stern, Yaakov, Strydom, Andre, Tang, Yi, Muniz Terrera, Graciela, Teunissen, Charlotte, Melo Van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, and O'Bryant, Sid E.

Subjects
Neurology, Ethnicity, Dementia, Alzheimer's disease, Alzheimer's disease--Social aspects, Dementia--Social aspects, 3. Good health
Abstract

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise “state-of-the-science” report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.

48. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Author

Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chetelat, Gael, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko H., Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctot, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle M., Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Muniz Terrera, Graciela Muniz Terrera, Muniz Terrera, Graciela, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, O’Bryant, Sid E., International Society to Advance Alzheimer’s Research and Treatment, Alzheimer’s Association, Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chetelat, Gael, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko H., Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctot, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle M., Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Muniz Terrera, Graciela Muniz Terrera, Muniz Terrera, Graciela, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, O’Bryant, Sid E., and International Society to Advance Alzheimer’s Research and Treatment, Alzheimer’s Association

Abstract

Babulal, G. M., Quiroz, Y. T., Albensi, B. C., Arenaza-Urquijo, E., Astell, A. J., Babiloni, C., . . . International Society to Advance Alzheimer's Research and Treatment,Alzheimer's Association. (2019). Perspectives on ethnic and racial disparities in alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimer's and Dementia, 15(2), 292-312. Available here

50. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.

Author

O'Keefe JH, Tintle NL, Harris WS, O'Keefe EL, Sala-Vila A, Attia J, Garg GM, Hure A, Bork CS, Schmidt EB, Venø SK, Chien KL, Chen YA, Egert S, Feldreich TR, Ärnlöv J, Lind L, Forouhi NG, Geleijnse JM, Pertiwi K, Imamura F, de Mello Laaksonen V, Uusitupa WM, Tuomilehto J, Laakso M, Lankinen MA, Laurin D, Carmichael PH, Lindsay J, Leander K, Laguzzi F, Swenson BR, Longstreth WT, Manson JE, Mora S, Cook NR, Marklund M, Melo van Lent D, Murphy R, Gudnason V, Ninomiya T, Hirakawa Y, Qian F, Sun Q, Hu F, Ardisson Korat AV, Risérus U, Lázaro I, Samieri C, Le Goff M, Helmer C, Steur M, Voortman T, Ikram MK, Tanaka T, Das JK, Ferrucci L, Bandinelli S, Tsai M, Guan W, Garg P, Verschuren WMM, Boer JMA, Biokstra A, Virtanen J, Wagner M, Westra J, Albuisson L, Yamagishi K, Siscovick DS, Lemaitre RN, and Mozaffarian D

Subjects
Humans, Prospective Studies, Eicosapentaenoic Acid, Docosahexaenoic Acids, Risk Factors, Hemorrhagic Stroke epidemiology, Fatty Acids, Omega-3, Stroke epidemiology, Ischemic Stroke
Abstract

Background: The effect of marine omega-3 PUFAs on risk of stroke remains unclear., Methods: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome., Results: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P <0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P <0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P =0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P =0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD., Conclusions: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke., Competing Interests: Disclosures Dr O’Keefe reports major ownership interest in Cardiotabs. Dr Harris reports minor ownership interest in Omegaquant Analytics, LLC. Dr Sala-Vila reports travel and grant support from California Walnut Commission. Dr Mora reports compensation for consultant services from Quest Diagnostics. Dr Murphy reports compensation from Pharmavite for consultant services. Dr Bork reports grants from Karen Elise Jensens Fond. Dr Ärnlöv reports compensation from Astellas Pharma for other services; compensation from Boehringer Ingelheim for consultant services; compensation from AstraZeneca for other services; and compensation from Novartis for other services. Dr Geleijnse reports grants from National Institutes of Health to other; grants from Upfield Europe BV to other; and grants from The Dutch Heart Foundation to other. Dr Manson reports grants from National Institutes of Health and compensation from National Institutes of Health for other services. Dr Mora reports compensation from Pfizer for consultant services; employment by Brigham and Women’s Hospital; grants from National Institute of Diabetes and Digestive and Kidney Diseases; and grants from National Heart, Lung, and Blood Institute. Dr Melo van Lent reports grants from National Institutes of Health and grants from Alzheimer’s Association. Dr Mozaffarian reports grants from Rockefeller Foundation; compensation from Beren Therapeutics for other services; stock holdings in HumanCo; compensation from January Inc. for other services; compensation from Filtricine for other services; compensation from Perfect Day for other services; compensation from Tiny Organics for other services; grants from Bill and Melinda Gates Foundation; compensation from Calibrate for other services; grants from Vail Innovative Global Research; grants from Kaiser Permanente Fund at East Bay Community Foundation; compensation from DayTwo for other services; compensation from Instacart health for other services; compensation from Season Health for other services; grants from National Institutes of Health; compensation from Barilla for consultant services; stock holdings in Calibrate; compensation from Kaiser Permanente Fund for other services; compensation from HumanCo for other services

Published
2024
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