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2. Hemopathogens in naturally infected bovine fetuses in Brazil

Author

Andrade, Leandro Silva, de Souza, Rayanne Soalheiro, Carvalho de Araujo, Andreina, Silva, Soraia de Oliveira, Melo, Maria Norma, Melo, Fabricio Gomes, Ribeiro, Gustavo Henrique Siqueira, de Sousa, Felipe Gaia, Bastos, Camila Valgas, Moreira, Tiago Facury, Meneses, Rodrigo Melo, Carvalho, Antônio Ultimo, Facury-Filho, Elias Jorge, and Silveira, Júlia Angélica Gonçalves

Published
2024
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3. Leishmania species infection of bats: A systematic review

Author

de Souza, Núbia Nunes, Ursine, Renata Luiz, Cruz, Dardiane Santos, Xavier, Emanuelle de Moura Santos, Queiroz, Lorena dos Reis Pereira, Falcão, Luiz Alberto Dolabela, de Araújo, Walter Santos, Gontijo, Célia Maria Ferreira, Melo, Maria Norma, and Vieira, Thallyta Maria

Published
2023
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12. Molecular detection of vector-borne pathogens in semen from dogs in southeastern Brazil

Author

Valle, Guilherme Ribeiro, primary, Ribeiro, Vitor Márcio, additional, Teles, Pedro Paulo de Abreu, additional, Ottino, Jennifer, additional, Salome, Daniel Magalhães, additional, Melo, Maria Norma, additional, Silva, Soraia de Oliveira, additional, da Silveira, Júlia Angélica Gonçalves, additional, Dias, Aline Hallais França, additional, and Dantas-Torres, Filipe, additional

Published
2022
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17. Chronic interstitial pneumonitis in dogs naturally infected with Leishmania (Leishmania) chagasi: a histopathological and morphometric study

Author

Gonçalves Ricardo, Tafuri Washington Luiz, Melo Maria Norma de, Raso Pedro, and Tafuri Wagner Luiz

Subjects
Chronic Interstitial Pneumonitis, Dogs, Histopathology, Morphometric analysis, Leishmania (Leishmania) chagasi, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Eighteen mongrel dogs of unknown age and naturally infected with Leishmania (Leishmania) chagasi, were obtained from the City Hall of Belo Horizonte, Brazil. Four dogs were used as control. Lung samples were obtained and immediately fixed in formalin. The histopathological picture of all lung tissue sections was a chronic and diffuse interstitial pneumonitis. The thickened inter-alveolar septa were characterized by the cellular exudate (mostly macrophages, lymphocytes and plasmocytes) associated with collagen deposition. Morphometric analysis showed greater septal thickness in the infected animals than in controls. In fact, the morphometric study of collagen stained with ammoniac silver confirmed a larger deposition of collagen in the infected animals. The parasitologic method was carried out during the study of the lesions on the slides. However, we did not observe any correlation between the histopathologic and morphometric data and the clinical status of the animals. We conclude that the pulmonary lesions observed in all naturally infected dogs were correlated with the disease and that the morphometric method used was satisfactory for the analysis of septal thickness and of increased collagen deposition, confirming the presence of fibrosis.

Published
2003

18. INFLUENCE OF MICROBIOTA IN EXPERIMENTAL CUTANEOUS LEISHMANIASIS IN SWISS MICE

Author

OLIVEIRA Marcia Rosa de, TAFURI Wagner Luis, NICOLI Jacques Robert, VIEIRA Enio Cardillo, MELO Maria Norma, and VIEIRA Leda Quercia

Subjects
Leishmania, Swiss mice, Microbiota, Germfree, Th1, Leishmaniasis, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Infection of Swiss/NIH mice with Leishmania major was compared with infection in isogenic resistant C57BL/6 and susceptible BALB/c mice. Swiss/NIH mice showed self-controlled lesions in the injected foot pad. The production of high levels of interferon-g (IFN-g) and low levels of interleukin-4 (IL-4) by cells from these animals suggests that they mount a Th1-type immune response. The importance of the indigenous microbiota on the development of murine leishmaniasis was investigated by infecting germfree Swiss/NIH in the hind footpad with L. major and conventionalizing after 3 weeks of infection. Lesions from conventionalized Swiss/NIH mice were significantly larger than conventional mice. Histopathological analysis of lesions from conventionalized animals showed abscesses of variable shapes and sizes and high numbers of parasitized macrophages. In the lesions from conventional mice, besides the absence of abscess formation, parasites were rarely observed. On the other hand, cells from conventional and conventionalized mice produced similar Th1-type response characterized by high levels of IFN-g and low levels of IL-4. In this study, we demonstrated that Swiss/NIH mice are resistant to L. major infection and that the absence of the normal microbiota at the beginning of infection significantly influenced the lesion size and the inflammatory response at the site of infection.

Published
1999

20. Concurrent cutaneous, visceral and ocular leishmaniasis caused by Leishmania (Viannia) braziliensis in a kidney transplant patient

Author

Gontijo Célia MF, Pacheco Raquel S, Oréfice Fernando, Lasmar Euler, Silva Eduardo S, and Melo Maria Norma

Subjects
Leishmania braziliensis, cutaneous, visceral and ocular leishmaniasis, kidney transplant, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

Although cases of leishmaniasis co-infection have been described in acquired immunodeficiency syndrome patients as well as those who have undergone organ transplants, to our knowledge, the present report is the first documented case of simultaneous cutaneous, visceral and ocular leishmaniasis due to Leishmania (Viannia) braziliensis in a transplant patient. The patient had been using immunosuppressive drugs since receiving a transplanted kidney. The first clinical signs of leishmaniasis included fever, thoracic pain, hepatosplenomegaly, leucopenia and anemia. The cutaneous disease was revealed by the presence of amastigotes in the skin biopsy. After three months, the patient presented fever with conjunctive hyperemia, intense ocular pain and low visual acuity. Parasites isolated from iliac crest, aqueous humor and vitreous body were examined using a range of molecular techniques. The same strain of L. (V.) braziliensis was responsible for the different clinical manifestations. The immunosuppressive drugs probably contributed to the dissemination of Leishmania.

Published
2002

22. Effect on cellular recruitment and the innate immune response by combining saponin, monophosphoryl lipid-A and Incomplete Freund’s Adjuvant with Leishmania (Viannia) braziliensis antigens for a vaccine formulation

Author

Vitoriano-Souza, Juliana, primary, Siqueira Mathias, Fernando Augusto, additional, Moreira, Nádia das Dores, additional, Aguiar-Soares, Rodrigo Dian de Oliveira, additional, de Abreu Vieira, Paula Melo, additional, Teixeira-Carvalho, Andréa, additional, Carneiro, Cláudia Martins, additional, Giunchetti, Rodolfo Cordeiro, additional, de Brito, Rory Cristiane Fortes, additional, Fujiwara, Ricardo Toshio, additional, Roatt, Bruno Mendes, additional, Melo, Maria Norma, additional, and Reis, Alexandre Barbosa, additional

Published
2019
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28. Distinct genetic profiles of Leishmania (Viannia) braziliensis associate with clinical variations in cutaneous-leishmaniasis patients from an endemic area in Brazil

Author

Quaresma, Patrícia Flávia, primary, de Brito, Cristiana Ferreira Alves, additional, Rugani, Jeronimo Marteleto Nunes, additional, Freire, Janaína de Moura, additional, Baptista, Rodrigo de Paula, additional, Moreno, Elizabeth Castro, additional, Gontijo, Raquel Carvalho, additional, Rego, Felipe Dutra, additional, Diniz, Joaquim Edemilson, additional, Melo, Maria Norma, additional, and Gontijo, Célia Maria Ferreira, additional

Published
2018
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30. Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis

Author

Guimarães, Agna Cristina, primary, Nogueira, Paula Monalisa, additional, Silva, Soraia de Oliveira, additional, Sadlova, Jovana, additional, Pruzinova, Katerina, additional, Hlavacova, Jana, additional, Melo, Maria Norma, additional, and Soares, Rodrigo Pedro, additional

Published
2018
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31. Fatores associados à leishmaniose visceral na área endêmica de Codó, estado do Maranhão, Brasil

Author

Silva, Larissa Barros da, Aquino, Dorlene Maria Cardoso de, Bezerra, Juliana Maria Trindade, Melo, Maria Norma, Leonardo, Francisco Santos, Guimarães e Silva, Antônia Suely, and Pinheiro, Valéria Cristina Soares

Abstract

Background and Objectives: Visceral leishmaniasis (VL) is a disease with a high impact on public health. This study describes the epidemiological situation of VL in the Municipality of Codó, state of Maranhão, Brazil, between the years 2007-2012. Method: Initially, an analytical study was performed between the years 2007-2011, which assessed the characteristics of individuals with VL, such as: gender, age, ethnicity, area of occurrence of the disease, signs and symptoms, co-infection with the virus Human immunodeficiency Virus/ visceral leishmaniasis (HIV/VL), work-related disease, indigenous and imported cases, criteria for VL confirmation, parasitological and immunological diagnoses, type of entry and the evolution of confirmed VL cases. In 2012, a survey was carried out in households, according to the systematic sampling process, in order to verify the characteristics of the households, the peridomiciliary area and knowledge of the assessed families on VL. Results: The incidence rate of the disease in the county was 86.31 cases/100,000 inhabitants and the mortality rate was 3.68%. The male gender was more affected, with 56% (t = 0.5023, p = 0.31), as well as mixed-race individuals, 88% (M = 17.9622; p = 0.00); the most reported symptoms were fever (16.3%), splenomegaly (15.3%) and pallor (14.4%) (M = 50.8473; p = 0.00). Five cases (3%) (M = 12.5673; p = 0.00) of HIV/VL coinfection were found, 166 (87%) were indigenous cases (M = 11.8600; p = 0.00) and 18 (9%) cases were work-related (M = 10.9768; p = 0.00). The parasitological diagnosis was made in 60.5% (M = 8.2986, p = 0.01). 100.00% of the residents had heard about the disease; however, 41.7% did not explain the form of transmission. Conclusion: Female individuals aged 5 to 19 years showed a higher record of the disease, while males aged 20 to 59 showed the same proportion of VL cases. Justificativa e Objetivos: A leishmaniose visceral é uma endemia no município de Codó, pelo risco da gravidade e o impacto na saúde de grande parcela da comunidade. Por isso, a realização deste estudo, para levantar a situação epidemiológica da doença nos últimos anos. Investigou-se ainda o aspecto clínico, epidemiológico e o conhecimento das famílias pesquisadas sobre a leishmaniose visceral. Métodos: Foram incluídas no estudo as fichas de notificação que apresentaram o diagnóstico de LV humana no referido período, de ambos os sexos e idades. Foram investigadas variáveis sociodemográficas (sexo, faixa etária, raça, área da ocorrência da doença), dados clínicos (manifestações clínicas, coinfecção com o HIV/LV, doença relacionada ao trabalho, relação de casos autóctones e importados), dados laboratoriais e classificação dos casos (critérios de confirmação para LV, diagnósticos parasitológico e imunológico, tipo de entrada e evolução dos casos confirmados). Resultados: No período de estudo, o coeficiente de incidência da doença no município foi 86,31 casos/100.000 habitantes e o coeficiente de letalidade foi 3,68%. O sexo masculino foi o mais acometido com 56% (t=0,5023; p=0,3105), a raça parda 88% (H=17,9622; p=0,0004); os sintomas foram: febre (16,3%), esplenomegalia (15,3%) e palidez (14,4%) (H=50,8473; p

Published
2016

34. Meglumine Antimoniate (Glucantime) Causes Oxidative Stress-Derived DNA Damage in BALB/c Mice Infected by Leishmania (Leishmania) infantum

Author

Moreira, Vanessa Ribeiro, primary, de Jesus, Luís Cláudio Lima, additional, Soares, Rossy-Eric Pereira, additional, Silva, Luis Douglas Miranda, additional, Pinto, Bruno Araújo Serra, additional, Melo, Maria Norma, additional, Paes, Antonio Marcus de Andrade, additional, and Pereira, Silma Regina Ferreira, additional

Published
2017
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36. Hemopathogens in naturally infected bovine fetuses in Brazil

Author

de Andrade, Leandro Silva, de Souza, Rayanne Soalheiro, Araujo, Andreina de Carvalho, Silva, Soraia de Oliveira, Melo, Maria Norma, Melo, Fabricio Gomes, Ribeiro, Gustavo Henrique Siqueira, de Sousa, Felipe Gaia, Bastos, Camila Valgas, Moreira, Tiago Facury, Meneses, Rodrigo Melo, de Carvalho, Antônio Ultimo, Facury-Filho, Elias Jorge, and da Silveira, Júlia Angélica Gonçalves

Abstract

•The transplacental transmission of bovine hemopathogens could occur earlier in pregnancy.•The transplacental transmission of hemopathogens may be underestimated.•The diagnosis of hemopathogens in naturally infected fetuses suggests the significance of this form of transmission in herds.

Published
2024
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38. Immunological changes in canine peripheral blood leukocytes triggered by immunization with first or second generation vaccines against canine visceral leishmaniasis

Author

Araújo, Márcio Sobreira Silva, Andrade, Renata Aline de, Avelar, Renato Sathler, Magalhães, Camila Paula, Carvalho, Andréa Teixeira de, Andrade, Mariléia Chaves, Campolina, Sabrina Sidney, Melo, Maria Norma, Vianna, Leonardo Rocha, Mayrink, Wilson, Reis, Alexandre Barbosa, Malaquias, Luiz Cosme Cotta, Rocha, Luciana Morais, and Martins Filho, Olindo Assis

Abstract

In this study, we summarized the major phenotypic/functional aspects of circulating leuko-cytes following canine immunization with Leishvaccine and Leishmune ®. Our findings showed that Leishvaccine triggered early changes in the innate immunity (neutrophils and eosinophils) with late alterations on monocytes. Conversely, Leishmune ® induced early phenotypic changes in both, neutrophils and monocytes. Moreover, Leishvaccine triggered mixed activation-related phenotypic changes on T-cells (CD4 + and CD8 +) and B-lymphocytes, hereas Leishmune® promoted a selective response, mainly associated with CD8 + T-cell activation. Mixed cytokine profile (IFN- /IL-4) was observed in Leishvaccine immunized dogs whereas a selective pro-inflammatory pattern (IFN- /NO) was induced by Leishmune ® vaccination. The distinct immunological profile triggered by Leishvaccine and Leishmune ® may be a direct consequence of the distinct biochemical composition of these immunobiological, i.e. complex versus purified Leishmaniaantigen along with Bacillus Calmette-Guérin (BCG) versus saponin adjuvant. Both immunobiologicals are able to acti-vate phagocytes and CD8 + T-cells and therefore could be considered as a putative vaccines against canine visceral leishmaniasis (CVL)

Published
2011

40. Evidence of Hantavirus Infection Among Bats in Brazil

Author

Sabino-Santos, Gilberto, primary, Melo, Maria Norma, additional, Maia, Felipe Gonçalves Motta, additional, Vieira, Thallyta Maria, additional, Jonsson, Colleen B., additional, Goodin, Douglas, additional, Gonçalves, Cristieli Barros, additional, Barroso, Patricia Doerl, additional, de Lara Muylaert, Renata, additional, Salazar-Bravo, Jorge, additional, Lima, Sabrina Miranda, additional, and Figueiredo, Luiz Tadeu Moraes, additional

Published
2015
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42. Evaluation of adjuvant activity of fractions derived from Agaricus blazei, when in association with the recombinant LiHyp1 protein, to protect against visceral leishmaniasis

Author

de Jesus Pereira, Nathália Cristina, primary, Régis, Wiliam César Bento, additional, Costa, Lourena Emanuele, additional, de Oliveira, Jamil Silvano, additional, da Silva, Alanna Gomes, additional, Martins, Vivian Tamietti, additional, Duarte, Mariana Costa, additional, de Souza, José Roberto Rodrigues, additional, Lage, Paula Sousa, additional, Schneider, Mônica Santos, additional, Melo, Maria Norma, additional, Soto, Manuel, additional, Soares, Sandra Aguiar, additional, Tavares, Carlos Alberto Pereira, additional, Chávez-Fumagalli, Miguel Angel, additional, and Coelho, Eduardo Antonio Ferraz, additional

Published
2015
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43. Leishmania enriettii: biochemical characterisation of lipophosphoglycans (LPGs) and glycoinositolphospholipids (GIPLs) and infectivity to Cavia porcellus

Author

Paranaíba, Larissa Ferreira, primary, de Assis, Rafael Ramiro, additional, Nogueira, Paula Monalisa, additional, Torrecilhas, Ana Claúdia, additional, Campos, João Henrique, additional, Silveira, Amanda Cardoso de Oliveira, additional, Martins-Filho, Olindo Assis, additional, Pessoa, Natalia Lima, additional, Campos, Marco Antônio, additional, Parreiras, Patrícia Martins, additional, Melo, Maria Norma, additional, Gontijo, Nelder de Figueiredo, additional, and Soares, Rodrigo Pedro Pinto, additional

Published
2015
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47. Leishmaniose visceral no Brasil: quadro atual, desafios e perspectivas

Author

Gontijo, Célia Maria Ferreira and Melo, Maria Norma

Subjects
Leishmaniose visceral no Brasil, Desafios e perspectivas, Prophylaxis, Challenges and prospects, Programa de controle, Profilaxia, Visceral leishmaniasis in Brazil, Control program
Abstract

No Brasil, a importância da leishmaniose visceral reside não somente na sua alta incidência e ampla distribuição, mas também na possibilidade de assumir formas graves e letais quando associada ao quadro de má nutrição e infecções concomitantes. A crescente urbanização da doença ocorrida nos últimos 20 anos coloca em pauta a discussão das estratégias de controle empregadas. Neste artigo foram analisados os principais aspectos biológicos, ambientais e sociais que influenciaram no processo de expansão e urbanização dos focos da doença. Os métodos disponíveis para o diagnóstico e tratamento não apresentam a eficácia e aplicabilidade desejadas, embora avanços promissores tenham sido alcançados com as pesquisas de novos testes diagnósticos e drogas terapêuticas. As medidas de controle da doença até agora implementadas foram incapazes de eliminar a transmissão e impedir a ocorrência de novas epidemias. É feita uma breve análise destas medidas e dos desafios a serem enfrentados. A prevenção da doença nos cães através da imunoprofilaxia aparece como uma alternativa para o controle. Uma nova vacina para cães, já testada em campo, está sendo industrializada e será comercializada no Brasil a partir de 2004. Apesar da existência de inúmeros estudos sobre a leishmaniose visceral humana e canina, muitas lacunas ainda precisam ser preenchidas. Visceral leishmaniasis has assumed an increasing importance in Brazil due to its high incidence and wide geographical distribution. When associated with malnutrition and co-infections it can prove to be fatal. A notable increase in transmission rates related to urbanization has been observed in the past 20 years. A combination of measures is needed to define new methods for reducing transmission. This paper analyzes the main biological, environmental and social aspects that have influenced the spread and urbanization of the disease. The diagnostic tests and drugs available have been shown to be insufficient in both applicability and efficiency. Significant advances have been made in the areas of pathogenesis, diagnosis and treatment, and they are discussed. Current control measures are unable to eliminate and prevent new outbreaks and a brief report is presented on the challenges faced. Vaccines against human and canine visceral leishmaniasis are being investigated, and there is hope that the first visceral leishmaniasis vaccine for dogs will become available in Brazil next year. Here we review these developments and identify priorities for research.

Published
2004

49. Mimotope-Based Vaccines of Leishmania infantum Antigens and Their Protective Efficacy against Visceral Leishmaniasis

Author

Costa, Lourena Emanuele, primary, Goulart, Luiz Ricardo, additional, Pereira, Nathália Cristina de Jesus, additional, Lima, Mayara Ingrid Sousa, additional, Duarte, Mariana Costa, additional, Martins, Vivian Tamietti, additional, Lage, Paula Sousa, additional, Menezes-Souza, Daniel, additional, Ribeiro, Tatiana Gomes, additional, Melo, Maria Norma, additional, Fernandes, Ana Paula, additional, Soto, Manuel, additional, Tavares, Carlos Alberto Pereira, additional, Chávez-Fumagalli, Miguel Angel, additional, and Coelho, Eduardo Antonio Ferraz, additional

Published
2014
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