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502 results on '"Melnitchouk, Nelya"'

5. Spatially organized multicellular immune hubs in human colorectal cancer.

Author

Pelka, Karin, Hofree, Matan, Chen, Jonathan, Sarkizova, Siranush, Pirl, Joshua, Jorgji, Vjola, Bejnood, Alborz, Dionne, Danielle, Ge, William, Xu, Katherine, Chao, Sherry, Zollinger, Daniel, Lieb, David, Reeves, Jason, Fuhrman, Christopher, Hoang, Margaret, Delorey, Toni, Nguyen, Lan, Waldman, Julia, Klapholz, Max, Wakiro, Isaac, Cohen, Ofir, Albers, Julian, Smillie, Christopher, Cuoco, Michael, Wu, Jingyi, Su, Mei-Ju, Yeung, Jason, Vijaykumar, Brinda, Magnuson, Angela, Asinovski, Natasha, Moll, Tabea, Goder-Reiser, Max, Applebaum, Anise, Brais, Lauren, DelloStritto, Laura, Denning, Sarah, Phillips, Susannah, Hill, Emma, Meehan, Julia, Frederick, Dennie, Sharova, Tatyana, Kanodia, Abhay, Todres, Ellen, Jané-Valbuena, Judit, Biton, Moshe, Izar, Benjamin, Lambden, Conner, Clancy, Thomas, Bleday, Ronald, Melnitchouk, Nelya, Irani, Jennifer, Kunitake, Hiroko, Berger, David, Srivastava, Amitabh, Hornick, Jason, Ogino, Shuji, Rotem, Asaf, Vigneau, Sébastien, Johnson, Bruce, Corcoran, Ryan, Sharpe, Arlene, Kuchroo, Vijay, Ng, Kimmie, Giannakis, Marios, Nieman, Linda, Boland, Genevieve, Aguirre, Andrew, Anderson, Ana, Rozenblatt-Rosen, Orit, Regev, Aviv, and Hacohen, Nir

Subjects
MSI, MSS, anti-tumor immunity, cell-cell interactions, colorectal cancer, mismatch repair-deficient, mismatch repair-proficient, scRNA-seq, spatial, tumor atlas, Bone Morphogenetic Proteins, Cancer-Associated Fibroblasts, Cell Compartmentation, Cell Line, Tumor, Chemokines, Cohort Studies, Colorectal Neoplasms, DNA Mismatch Repair, Endothelial Cells, Gene Expression Regulation, Neoplastic, Humans, Immunity, Inflammation, Monocytes, Myeloid Cells, Neutrophils, Stromal Cells, T-Lymphocytes, Transcription, Genetic
Abstract

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent normal tissues of 28 MMRp and 34 MMRd individuals. Analysis of 88 cell subsets and their 204 associated gene expression programs revealed extensive transcriptional and spatial remodeling across tumors. To discover hubs of interacting malignant and immune cells, we identified expression programs in different cell types that co-varied across tumors from affected individuals and used spatial profiling to localize coordinated programs. We discovered a myeloid cell-attracting hub at the tumor-luminal interface associated with tissue damage and an MMRd-enriched immune hub within the tumor, with activated T cells together with malignant and myeloid cells expressing T cell-attracting chemokines. By identifying interacting cellular programs, we reveal the logic underlying spatially organized immune-malignant cell networks.

Published
2021

9. Stop the BleedⓇ

Author

Jacobs, Lenworth, Keating, Jane J., Hunt, Richard C., Butler, Frank K., Pons, Peter T., Gestring, Mark, Bulger, Eileen, Eastman, Alexander, Kerby, Jeffrey, Hashmi, Zain, Fridling, Jeremy, Inaba, Kenji, Matsushima, Kazuhide, Goralnick, Eric, Melnitchouk, Nelya, and Welten, Vanessa

Published
2022
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13. Highly Sensitive Circulating Tumor DNA Assay Aids Clinical Management of Radiographically Occult Isolated Peritoneal Metastases in Patients With GI Cancer

Author

Singh, Harshabad, Klempner, Samuel J., Melnitchouk, Nelya, Chander, Deepak P., Negrea, Ovidiu George, Patel, Anuj K., Schlechter, Benjamin L., Rubinson, Douglas A., Huffman, Brandon M., Nambiar, Chetan, Remland, Joshua, Andrews, Elizabeth, Leahy, Megan E., Brais, Lauren K., Enzinger, Peter C., Mamon, Harvey J., Giannakis, Marios, Meyerhardt, Jeffrey A., Ng, Kimmie, Perez, Kimberly J., Aguirre, Andrew J., Clark, Jeffrey W., Cleary, James M., and Wolpin, Brian M.

Published
2023
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18. Effect of war on radiotherapy in Ukraine and how to help.

Author

Kovalchuk, Nataliya, primary, Zelinskyi, Ruslan, additional, Suchowerska, Natalka, additional, Lozko, Yuliia, additional, Brovchuk, Serhii, additional, Shepil, Zoia, additional, Melnitchouk, Nelya, additional, Iakovenko, Viktor, additional, and Beznosenko, Andriy, additional

Published
2024
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26. Enhancing trauma care in Ukraine amid conflict: A successful implementation of the modified advanced trauma life support course in an active war zone.

Author

Dzhemiliev, Ali, Lienau, Beck, Melnitchouk, Nelya, Schmid, Alexis, Loevinsohn, Gideon, Lopatniuk, Oleksii, Carton‐Rossen, Noah, Sydlowski, Meaghan, Darnytskyi, Anton, Murray, Kathleen, Kushner, Olha, Strong, Jonathan, Martin, Lindsey, Ali, Javed, Roberts, John, Mooney, David, Hochman, Beth, Owens, Mike, Sidhwa, Feroze, and Rudas, Ivan

Subjects
RUSSIA-Ukraine Conflict, 2014-, CITIES & towns, MEDICAL personnel, WAR, CONSORTIA
Abstract

Background: Following the 2022 Russian invasion, Ukraine's healthcare system suffered extensive damage, with over 1000 medical facilities destroyed, exacerbating the trauma care crisis. The absence of standardized trauma training left Ukrainian healthcare providers ill‐equipped to manage the surge in trauma cases amid conflict. To bridge this gap, we implemented advanced trauma life support (ATLS) courses in Ukraine amid active warfare, aiming to enhance trauma care expertise among healthcare professionals. Methods: A consortium, including the International Medical Corps, Harvard Humanitarian Initiative, and others, responded to a request from the Ukrainian Ministry of Health. The ATLS curriculum, translated into Ukrainian, guided the training, with US‐based instructors sent to Ukraine for teaching. Despite logistical challenges, such as missile attacks and curfews, the courses ran in multiple Ukrainian cities over 3 months. Course effectiveness was evaluated through pre‐ and post‐course knowledge tests, self‐efficacy surveys, and satisfaction assessments. Results: Ten ATLS courses trained 213 Ukrainian healthcare providers across five deployments. Significant improvements in knowledge scores (p < 0.05) and enhanced self‐reported confidence in trauma management were observed. Notably, no casualties were reported among instructors or students, highlighting program safety despite security challenges. Conclusions: Our study demonstrates successful ATLS course implementation in an active war zone, filling a critical gap in trauma education in Ukraine. Despite challenges, the program significantly enhanced participants' trauma care knowledge and confidence. Collaboration between international and local partners was pivotal. This model can serve as a valuable framework for trauma education globally, improving outcomes in conflict zones and resource‐limited settings. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Strengths and opportunities for improvement in surgical education in Ukraine: A qualitative study.

Author

Dzhemiliev, Ali, Antoniv, Marta, Huivaniuk, Inesa, Kizub, Darya, Reich, Amanda J., Kochis, Michael, Prystaia, Anastasiia, Beliechenko, Svitlana, Danylyshyn, Maksym, Ivanykovych, Taras, Semeniv, Solomiia, Beznosenko, Andriy, Shabat, Galyna, Kopetskyi, Viacheslav, Zmijewski, Polina, and Melnitchouk, Nelya

Abstract

Background: The full‐scale invasion of Ukraine by Russia in 2022 has significantly impacted the country's healthcare system including surgical education. To assess the current state and identify the strengths and opportunities for the improvement of Ukraine's surgical education system during the peri‐war period, this study is one of the first to explore the state of surgical education across Ukraine in peri‐war, providing essential insights for current and postwar healthcare reconstruction. Methods: This qualitative study involved semi‐structured interviews with 24 Ukrainian surgical residents, surgeons, and program leadership from various regions. The study focused on clinical training, didactics, mentorship, autonomy, resident evaluation, the impact of war, and gender disparities in surgical education. Data analysis was conducted using a rapid qualitative analysis technique. Results: Interviews revealed strengths in surgical education such as adaptability to war conditions and international collaborations. However, opportunities for improvement were identified including a lack of structured clinical and didactic experiences, limited autonomy and access to simulators, gender discrimination, and war‐time challenges. These issues highlight a need for more comprehensive training and support systems for surgical trainees in Ukraine. Conclusions: The study underscores the resilience and adaptability of Ukrainian surgical education in the face of war while also emphasizing the need for significant improvements. It calls for implementing structured training programs, enhanced mentorship, and attention to gender equality. These findings are crucial for improving surgical education in Ukraine and can be used as an example for other lower‐middle‐income countries, especially in conflict settings. [ABSTRACT FROM AUTHOR]

Published
2024
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