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1. The Overweight Paradox: Impact of Body Mass Index on Patients Undergoing VATS Lobectomy or Segmentectomy

Author

Parini, Sara, Azzolina, Danila, Massera, Fabio, Mastromarino, Maria Giovanna, Papalia, Esther, Baietto, Guido, Curcio, Carlo, Crisci, Roberto, Rena, Ottavio, Alloisio, Marco, Amore, Dario, Ampollini, Luca, Ardò, Nicoletta, Argnani, Desideria, Baisi, Alessandro, Bandiera, Alessandro, Benato, Cristiano, Benvenuti, Mauro Roberto, Bertani, Alessandro, Bortolotti, Luigi, Bottoni, Edoardo, Breda, Cristiano, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Carleo, Francesco, Cavallesco, Giorgio, Cherchi, Roberto, De Palma, Angela, Dell'Amore, Andrea, Della Beffa, Vittorio, Divisi, Duilio, Dolci, Giampiero, Droghetti, Andrea, Ferrari, Paolo, Fontana, Diego, Gasparri, Roberto, Gavezzoli, Diego, Ghisalberti, Marco, Giovanardi, Michele, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Lausi, Paolo, Lo Giudice, Fabio, Londero, Francesco, Lopez, Camillo, Mancuso, Maurizio, Maniscalco, Pio, Margaritora, Stefano, Marulli, Giuseppe, Mazza, Federico, Meacci, Elisa, Melloni, Giulio, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Paladini, Piero, Pariscenti, Gianluca, Perkmann, Reinhold, Pernazza, Fausto, Pirondini, Emanuele, Puma, Francesco, Raveglia, Federico, Refai, Majed, Rinaldo, Alessandro, Risso, Carlo, Rizzardi, Giovanna, Rotolo, Nicola, Scarci, Marco, Solli, Piergiorgio, Sollitto, Francesco, Spaggiari, Lorenzo, Stefani, Alessandro, Stella, Franco, Surrente, Corrado, Tancredi, Giorgia, Terzi, Alberto, Torre, Massimo, Tosi, Davide, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, and Zaraca, Francesco

Published
2023
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2. Impact of Triple Inhaler Therapy on COPD Patients with Non-Small Cell Lung Cancer After Radical Surgery: A Single-Centre Retrospective Analysis.

Author

Bertuccio, Francesco Rocco, D'Agnano, Vito, Cordoni, Simone, Tafa, Mitela, Novy, Cristina, Baio, Nicola, Mucaj, Klodjana, Bortolotto, Chandra, Melloni, Giulio, Bianco, Andrea, Corsico, Angelo Guido, Perrotta, Fabio, and Stella, Giulia Maria

Subjects
NON-small-cell lung carcinoma, CHRONIC obstructive pulmonary disease, LUNG cancer, LUNG surgery, SYMPTOMS
Abstract

Background: Chronic obstructive pulmonary disease (COPD) is among the most relevant comorbidity associated with lung cancer. The advent of innovative triple treatment approaches for COPD has significantly improved patients' quality of life and outcomes. Few data are available regarding the impact of triple inhaler therapy on patients featuring COPD and lung cancer. Methods: We retrospectively evaluated the impact of triple inhale bronchodilators in a cohort of 56 patients with treated COPD who underwent lung surgery for primary cancer. Results: Triple bronchodilation can help to relieve the symptoms of the disease and improve lung function, allowing people with lung cancer to reduce the risk of serious exacerbations and improve their quality of life. Conclusions: Within the limits of the study, it should be underlined that bronchodilators can effectively affect the outcome and performance status after thoracic surgery. [ABSTRACT FROM AUTHOR]

Published
2025
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3. Post-operative outcomes and quality of life assessment after thoracoscopic lobectomy for Non-small-cell lung cancer in octogenarians: Analysis from a national database

Author

Alloisio, Marco, Amore, Dario, Ampollini, Luca, Andreetti, Claudio, Argnani, Desideria, Baietto, Guido, Bandiera, Alessandro, Benato, Cristiano, Benvenuti, Mauro Roberto, Bertani, Alessandro, Bertolaccini, Luca, Bortolotti, Luigi, Bottoni, Edoardo, Breda, Cristiano, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Casadio, Caterina, Cavallesco, Giorgio, Cherchi, Roberto, Crisci, Roberto, Curcio, Carlo, Dell’Amore, Andrea, Della Beffa, Vittorio, Dolci, Giampiero, Droghetti, Andrea, Ferrari, Paolo A., Fontana, Diego, Gargiulo, Gaetano, Gasparri, Roberto, Gavezzoli, Diego, Ghisalberti, Marco, Giovanardi, Michele, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Iurilli, Luciano, Lausi, Paolo, Lo Giudice, Fabio, Londero, Francesco, Luzzi, Luca, Lopez, Camillo, Mancuso, Maurizio, Maniscalco, Pio, Margaritora, Stefano, Meacci, Elisa, Melloni, Giulio, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Pariscenti, Gianluca, Perkmann, Reinhold, Pernazza, Fausto, Pirondini, Emanuele, Poggi, Camilla, Puma, Francesco, Refai, Majed, Rinaldo, Alessandro, Rizzardi, Giovanna, Rosso, Lorenzo, Rotolo, Nicola, Russo, Emanuele, Sabbatini, Armando, Scarci, Marco, Spaggiari, Lorenzo, Stefani, Alessandro, Solli, Piergiorgio, Surrente, Corrado, Terzi, Alberto, Torre, Massimo, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, Zaccagna, Gino, Zaraca, Francesco, Bongiolatti, Stefano, and Borgianni, Sara

Published
2021
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4. Phase I Clinical Trial on Pleural Mesothelioma Using Neoadjuvant Local Administration of Paclitaxel-Loaded Mesenchymal Stromal Cells (PACLIMES Trial): Study Rationale and Design.

Author

Stella, Giulia Maria, Lisini, Daniela, Pedrazzoli, Paolo, Galli, Giulia, Bortolotto, Chandra, Melloni, Giulio, D'Ambrosio, Gioacchino, Klersy, Catherine, Grosso, Amelia, Paino, Francesca, Tomaselli, Stefano, Saracino, Laura, Alessandri, Giulio, Pessina, Augusto, Grignani, Elena, Rosti, Vittorio, Corsico, Angelo Guido, Comoli, Patrizia, and Agustoni, Francesco

Subjects
MESENCHYMAL stem cells, CLINICAL trials, PLEURAL tumors, TREATMENT effectiveness, COMBINED modality therapy, MESOTHELIOMA, PACLITAXEL
Abstract

Simple Summary: The phase I monocentric PACLIMES trial evaluates the effects of local administration of an innovative tool composed of mesenchymal stromal cells loaded with paclitaxel directly injected in the pleural space in mesothelioma patients in a neoadjuvant setting. The trial explores the safety and toxicity of the drug product, but also an exploratory objective aimed at evaluating its antiproliferative capacity. The results of this study will validate a promising therapeutic option for an unmet clinical need such as pleural mesothelioma and open the way to an efficient management of malignant pleural effusion in case of advanced cancers from different sites of primary origin. Background and rationale. Pleural mesothelioma (PM) is a rare and aggressive neoplasm that originates from the pleural mesothelium and whose onset is mainly linked to exposure to asbestos, which cannot be attacked with truly effective therapies with consequent poor prognosis. The rationale of this study is based on the use of mesenchymal stromal cells (MSCs) as a vehicle for chemotherapy drugs to be injected directly into the pathological site, such as the pleural cavity. Study design. The study involves the use of a conventional chemotherapeutic drug, Paclitaxel (PTX), which is widely used in the treatment of different types of solid tumors, including PM, although some limitations are related to pharmacokinetic aspects. The use of PTX-loaded MSCs to treat PM should provide several potential advantages over the systemically administered drug as reduced toxicity and increased concentration of active drug in the tumor-surrounding context. The PACLIMES trial explores the safety and toxicity of the local administration of Paclimes in chemonaive patients, candidates for pleurectomy. The secondary objective is to find the effective Paclimes dose for subsequent phase II studies and to observe and record the antitumor activity. Future direction. The experimental pre-clinical background and rationale are discussed as well. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Assessment of Imatinib Anti-Remodeling Activity on a Human Precision Cut Lung Slices Model.

Author

Bozzini, Sara, Bozza, Eleonora, Bagnera, Cecilia, Morbini, Patrizia, Lettieri, Sara, Della Zoppa, Matteo, Melloni, Giulio, Saracino, Laura, Belliato, Mirko, and Meloni, Federica

Subjects
PROTEIN-tyrosine kinase inhibitors, PULMONARY fibrosis, EPITHELIAL cells, IMATINIB, PHARMACODYNAMICS
Abstract

Recent studies have emphasized the critical role of alteration in cellular plasticity in the development of fibrotic disorders, particularly pulmonary fibrosis, prompting further investigation into molecular mechanisms and therapeutic approaches. In this context, Precision Cut Lung Slices (PCLSs) emerge as a valuable ex vivo research tool. The process of PCLSs generation preserves most features of the naïve lung tissue, such as its architecture and complex cellular composition. We previously stimulated normal lung PCLSs with two different stimuli (fibrotic cocktail, composed by platelet lysate and TGFβ, or neutrophil extracellular traps) and we observed a significant elevation of Epithelial–Mesenchymal Transition (EMT) markers from 24 h to 72 h of culture. The aim of our work was to exploit this PCLSs based ex vivo model of EMT, to evaluate the effect of imatinib, an old tyrosine kinase inhibitor with reported anti-remodeling activities in vitro and in animal models. Imatinib treatment significantly decreased α-SMA and collagen expression already starting from 24 h on stimulated PCLS. Imatinib showed a significant toxicity on unstimulated cells (3-fold increase in ACTA2 expression levels at 24 h, 1.5-fold increase in COL1A1 expression levels at 24 h, 2-fold increase in COL3A1 expression levels at 72 h). Further evaluations on specific cell lines pointed out that drug effects were mainly directed towards A549 and LFs. In conclusion, our model confirms the anti-remodeling activity of imatinib but suggests that its direct delivery to alveolar epithelial cells as recently attempted by inhalatory preparation of the drug might be associated with a non-negligible epithelial cell toxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Air leak and intraoperative bleeding in thoracic surgery: a Delphi consensus among the members of Italian society of thoracic surgery

Author

Cardillo, Giuseppe, primary, Nosotti, Mario, additional, Scarci, Marco, additional, Torre, Massimo, additional, Alloisio, Marco, additional, Benvenuti, Mauro Roberto, additional, Bertani, Alessandro, additional, Cagini, Lucio, additional, Casablanca, Giuseppe, additional, Cavallesco, Giorgio, additional, Cherchi, Roberto, additional, Crucitti, Pierfilippo, additional, Curcio, Carlo, additional, Denegri, Andrea, additional, Droghetti, Andrea, additional, Guggino, Gianluca, additional, Imperatori, Andrea, additional, Infante, Maurizio Valentino, additional, Lucchi, Marco, additional, Macrì, Paolo, additional, Marulli, Giuseppe, additional, Melloni, Giulio, additional, Paci, Massimiliano, additional, Paladini, Piero, additional, Pariscenti, Gian Luca, additional, Potenza, Enrico, additional, Rea, Federico, additional, Refai, Majed, additional, Rena, Ottavio, additional, Ricciardi, Sara, additional, Rusca, Michele, additional, Sollitto, Francesco, additional, Taurchini, Marco, additional, Terzi, Alberto, additional, Voltolini, Luca, additional, and Crisci, Roberto, additional

Published
2022
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13. The Overweight Paradox: Impact of Body Mass Index on Patients Undergoing VATS Lobectomy or Segmentectomy

Author

Parini, Sara, primary, Azzolina, Danila, additional, Massera, Fabio, additional, Mastromarino, Maria Giovanna, additional, Papalia, Esther, additional, Baietto, Guido, additional, Curcio, Carlo, additional, Crisci, Roberto, additional, Rena, Ottavio, additional, Alloisio, Marco, additional, Amore, Dario, additional, Ampollini, Luca, additional, Ardò, Nicoletta, additional, Argnani, Desideria, additional, Baisi, Alessandro, additional, Bandiera, Alessandro, additional, Benato, Cristiano, additional, Benvenuti, Mauro Roberto, additional, Bertani, Alessandro, additional, Bortolotti, Luigi, additional, Bottoni, Edoardo, additional, Breda, Cristiano, additional, Camplese, Pierpaolo, additional, Carbognani, Paolo, additional, Cardillo, Giuseppe, additional, Carleo, Francesco, additional, Cavallesco, Giorgio, additional, Cherchi, Roberto, additional, De Palma, Angela, additional, Dell'Amore, Andrea, additional, Della Beffa, Vittorio, additional, Divisi, Duilio, additional, Dolci, Giampiero, additional, Droghetti, Andrea, additional, Ferrari, Paolo, additional, Fontana, Diego, additional, Gasparri, Roberto, additional, Gavezzoli, Diego, additional, Ghisalberti, Marco, additional, Giovanardi, Michele, additional, Gonfiotti, Alessandro, additional, Guerrera, Francesco, additional, Imperatori, Andrea, additional, Infante, Maurizio, additional, Lausi, Paolo, additional, Lo Giudice, Fabio, additional, Londero, Francesco, additional, Lopez, Camillo, additional, Mancuso, Maurizio, additional, Maniscalco, Pio, additional, Margaritora, Stefano, additional, Marulli, Giuseppe, additional, Mazza, Federico, additional, Meacci, Elisa, additional, Melloni, Giulio, additional, Morelli, Angelo, additional, Mucilli, Felice, additional, Natali, Pamela, additional, Negri, Giampiero, additional, Nicotra, Samuele, additional, Nosotti, Mario, additional, Paladini, Piero, additional, Pariscenti, Gianluca, additional, Perkmann, Reinhold, additional, Pernazza, Fausto, additional, Pirondini, Emanuele, additional, Puma, Francesco, additional, Raveglia, Federico, additional, Refai, Majed, additional, Rinaldo, Alessandro, additional, Risso, Carlo, additional, Rizzardi, Giovanna, additional, Rotolo, Nicola, additional, Scarci, Marco, additional, Solli, Piergiorgio, additional, Sollitto, Francesco, additional, Spaggiari, Lorenzo, additional, Stefani, Alessandro, additional, Stella, Franco, additional, Surrente, Corrado, additional, Tancredi, Giorgia, additional, Terzi, Alberto, additional, Torre, Massimo, additional, Tosi, Davide, additional, Vinci, Damiano, additional, Viti, Andrea, additional, Voltolini, Luca, additional, and Zaraca, Francesco, additional

Published
2022
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18. Post-operative outcomes and quality of life assessment after thoracoscopic lobectomy for Non-small-cell lung cancer in octogenarians: Analysis from a national database

Author

Bongiolatti, Stefano, primary, Gonfiotti, Alessandro, additional, Borgianni, Sara, additional, Crisci, Roberto, additional, Curcio, Carlo, additional, Voltolini, Luca, additional, Alloisio, Marco, additional, Amore, Dario, additional, Ampollini, Luca, additional, Andreetti, Claudio, additional, Argnani, Desideria, additional, Baietto, Guido, additional, Bandiera, Alessandro, additional, Benato, Cristiano, additional, Benvenuti, Mauro Roberto, additional, Bertani, Alessandro, additional, Bertolaccini, Luca, additional, Bortolotti, Luigi, additional, Bottoni, Edoardo, additional, Breda, Cristiano, additional, Camplese, Pierpaolo, additional, Carbognani, Paolo, additional, Cardillo, Giuseppe, additional, Casadio, Caterina, additional, Cavallesco, Giorgio, additional, Cherchi, Roberto, additional, Dell’Amore, Andrea, additional, Della Beffa, Vittorio, additional, Dolci, Giampiero, additional, Droghetti, Andrea, additional, Ferrari, Paolo A., additional, Fontana, Diego, additional, Gargiulo, Gaetano, additional, Gasparri, Roberto, additional, Gavezzoli, Diego, additional, Ghisalberti, Marco, additional, Giovanardi, Michele, additional, Guerrera, Francesco, additional, Imperatori, Andrea, additional, Infante, Maurizio, additional, Iurilli, Luciano, additional, Lausi, Paolo, additional, Lo Giudice, Fabio, additional, Londero, Francesco, additional, Luzzi, Luca, additional, Lopez, Camillo, additional, Mancuso, Maurizio, additional, Maniscalco, Pio, additional, Margaritora, Stefano, additional, Meacci, Elisa, additional, Melloni, Giulio, additional, Morelli, Angelo, additional, Mucilli, Felice, additional, Natali, Pamela, additional, Negri, Giampiero, additional, Nicotra, Samuele, additional, Nosotti, Mario, additional, Pariscenti, Gianluca, additional, Perkmann, Reinhold, additional, Pernazza, Fausto, additional, Pirondini, Emanuele, additional, Poggi, Camilla, additional, Puma, Francesco, additional, Refai, Majed, additional, Rinaldo, Alessandro, additional, Rizzardi, Giovanna, additional, Rosso, Lorenzo, additional, Rotolo, Nicola, additional, Russo, Emanuele, additional, Sabbatini, Armando, additional, Scarci, Marco, additional, Spaggiari, Lorenzo, additional, Stefani, Alessandro, additional, Solli, Piergiorgio, additional, Surrente, Corrado, additional, Terzi, Alberto, additional, Torre, Massimo, additional, Vinci, Damiano, additional, Viti, Andrea, additional, Zaccagna, Gino, additional, and Zaraca, Francesco, additional

Published
2021
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28. Antiplatelet Therapy with Cangrelor in Patients Undergoing Surgery after Coronary Stent Implantation: A Real-World Bridging Protocol Experience

Author

Rossini, Roberta, additional, Masiero, Giulia, additional, Fruttero, Claudia, additional, Passamonti, Enrico, additional, Calvaruso, Elba, additional, Cecconi, Moreno, additional, Carlucci, Cesare, additional, Mojoli, Marco, additional, Guido, Parodi, additional, Talanas, Giuseppe, additional, Pierini, Simona, additional, Canova, Paolo, additional, De Cesare, Nicoletta, additional, Luceri, Stefania, additional, Barzaghi, Nicoletta, additional, Melloni, Giulio, additional, Baralis, Giorgio, additional, Locatelli, Alessandro, additional, Musumeci, Giuseppe, additional, and Angiolillo, Dominick J., additional

Published
2020
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32. Presentation S1 - Supplemental material for Single-Stage Localization and Thoracoscopic Removal of Nonpalpable Pulmonary Nodules in a Hybrid Operating Room

Author

Mazza, Federico, Venturino, Massimiliano, Peano, Enrico, Balderi, Alberto, Turello, Davide, Locatelli, Alessandro, and Melloni, Giulio

Subjects
FOS: Clinical medicine, 110323 Surgery
Abstract

Supplemental material, Presentation S1, for Single-Stage Localization and Thoracoscopic Removal of Nonpalpable Pulmonary Nodules in a Hybrid Operating Room by Federico Mazza, Massimiliano Venturino, Enrico Peano, Alberto Balderi, Davide Turello, Alessandro Locatelli and Giulio Melloni in Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery

Published
2020
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37. Artificial intelligence and radiomics enhance the positive predictive value of digital chest tomosynthesis for lung cancer detection within SOS clinical trial.

Author

Chauvie, Stéphane, De Maggi, Adriano, Baralis, Ilaria, Dalmasso, Federico, Berchialla, Paola, Priotto, Roberto, Violino, Paolo, Mazza, Federico, Melloni, Giulio, Grosso, Maurizio, SOS Study team, Biggi, Alberto, Campione, Andrea, Fortunato, Mirella, Colantonio, Ida, Stanzi, Alessia, Noceti, Paolo, Pellegrino, Paolo, and Russi, Elvio

Subjects
TOMOSYNTHESIS, LUNG cancer, ARTIFICIAL intelligence, CLINICAL trials, PULMONARY nodules, DIGITAL image processing, SEMANTICS, RESEARCH, RESEARCH evaluation, RESEARCH methodology, LUNG tumors, EARLY detection of cancer, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, PSYCHOLOGICAL tests, COMPUTED tomography, LOGISTIC regression analysis, ALGORITHMS, MEDICAL specialties & specialists
Abstract

Objective: To enhance the positive predictive value (PPV) of chest digital tomosynthesis (DTS) in the lung cancer detection with the analysis of radiomics features.Method: The investigation was carried out within the SOS clinical trial (NCT03645018) for lung cancer screening with DTS. Lung nodules were identified by visual analysis and then classified using the diameter and the radiological aspect of the nodule following lung-RADS. Haralick texture features were extracted from the segmented nodules. Both semantic variables and radiomics features were used to build a predictive model using logistic regression on a subset of variables selected with backward feature selection and using two machine learning: a Random Forest and a neural network with the whole subset of variables. The methods were applied to a train set and validated on a test set where diagnostic accuracy metrics were calculated.Results: Binary visual analysis had a good sensitivity (0.95) but a low PPV (0.14). Lung-RADS classification increased the PPV (0.19) but with an unacceptable low sensitivity (0.65). Logistic regression showed a mildly increased PPV (0.29) but a lower sensitivity (0.20). Random Forest demonstrated a moderate PPV (0.40) but with a low sensitivity (0.30). Neural network demonstrated to be the best predictor with a high PPV (0.95) and a high sensitivity (0.90).Conclusions: The neural network demonstrated the best PPV. The use of visual analysis along with neural network could help radiologists to reduce the number of false positive in DTS.Key Points: • We investigated several approaches to enhance the positive predictive value of chest digital tomosynthesis in the lung cancer detection. • Neural network demonstrated to be the best predictor with a nearly perfect PPV. • Neural network could help radiologists to reduce the number of false positive in DTS. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors

Author

Fontana, Raffaella, primary, Raccosta, Laura, additional, Rovati, Lucrezia, additional, Steffensen, Knut R., additional, Paniccia, Aida, additional, Jakobsson, Tomas, additional, Melloni, Giulio, additional, Bandiera, Alessandro, additional, Mangili, Giorgia, additional, Bergamini, Alice, additional, Maggioni, Daniela, additional, Doglioni, Claudio, additional, Crocchiolo, Roberto, additional, Cella, Marina, additional, Mattioli, Michela, additional, Battaglia, Cristina, additional, Colonna, Marco, additional, and Russo, Vincenzo, additional

Published
2018
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40. TCT-643 Antiplatelet therapy with cangrelor in patients undergoing surgery after coronary stent implantation: a real-world bridging protocol experience

Author

Rossini, Roberta, primary, Masiero, Giulia, additional, Rolfo, Fabrizio, additional, Pappalardo, Federico, additional, Fruttero, Claudia, additional, Passamonti, Enrico, additional, Calvaruso, Elba, additional, Cecconi, Moreno, additional, Carlucci, Cesare, additional, Bertone, Elisa, additional, Barzaghi, Nicoletta, additional, Melloni, Giulio, additional, Stanzi, Alessia, additional, Locatelli, Alessandro, additional, Baralis, Giorgio, additional, Angiolillo, Dominick, additional, and Musumeci, Giuseppe, additional

Published
2018
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44. Solitary Fibrous Tumour of the Pleura Presenting as a Spontaneous Massive Haemothorax

Author

Negri, Giampiero, Bandiera, Alessandro, Ciriaco, Paola, Melloni, Giulio, Carretta, Angelo, Cremona, George Ian, and Zannini, Piero

Subjects
Article Subject, respiratory tract diseases
Abstract

Solitary fibrous tumours of the pleura are rare neoplasms. These tumours are generally asymptomatic and incidentally diagnosed. Symptoms, if present, are nonspecific such as cough, dyspnea, and chest pain. This report describes the case of a 38-year-old woman admitted to our department after the onset of a right massive spontaneous haemothorax requiring emergency surgical treatment. Intraoperatively a bleeding pleural mass was found to be the cause of the haemothorax. The tumour was successfully resected and the patient made an uneventful recovery. Histological examination revealed the mass to be a solitary fibrous tumour of the pleura.

Published
2014
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45. Management of Intrathoracic Benign Schwannomas of the Brachial Plexus

Author

Bandiera, Alessandro, Negri, Giampiero, Melloni, Giulio, Mandelli, Carlo, Gerevini, Simonetta, Carretta, Angelo, Ciriaco, Paola, Puglisi, Armando, and Zannini, Piero

Subjects
Article Subject
Abstract

Primary tumours of the brachial plexus are rare entities. They usually present as extrathoracic masses located in the supraclavicular region. This report describes two cases of benign schwannomas arising from the brachial plexus with an intrathoracic growth. In the first case the tumour was completely intrathoracic and it was hardly removed through a standard posterolateral thoracotomy. In the second case the tumour presented as a cervicomediastinal lesion and it was resected through a one-stage combined supraclavicular incision followed by left video-assisted thoracoscopic surgery. A brachial plexus tumour should be suspected not only in patients with a supraclavicular or cervicomediastinal mass but also in those with intrathoracic apical lesions. A preoperative magnetic resonance imaging study of brachial plexus should be performed in such cases in order to plan the correct surgical approach.

Published
2014
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46. Tailored intraoperative localization of non‐palpable pulmonary lesions for thoracoscopic wedge resection using hybrid room technology.

Author

Stanzi, Alessia, Mazza, Federico, Lucio, Francesco, Ghirardo, Donatella, Grosso, Maurizio, Locatelli, Alessandro, and Melloni, Giulio

Subjects
INTRAOPERATIVE care, INTRAOPERATIVE radiotherapy, LUNG infections, CHEST endoscopic surgery, MEDICAL technology
Abstract

Abstract: Introduction: VATS wedge resection can require conversion to thoracotomy when pulmonary lesions cannot be identified. Hybrid operating rooms (HORs) provide real‐time image acquisition capabilities allowing the intraoperative placement of markers to facilitate the removal of non‐palpable nodules during VATS. Objectives: To present our workflow based on the alternative use of two different markers according to the location of the lung lesion and report our initial results. Methods: All consecutive patients with non‐palpable lesions requiring VATS wedge resection underwent localization of the targets in HOR. Lesions were considered non‐palpable if they were small (<1 cm), deep (>1 cm from surface), subsolid, or located within a dystrophic area. Anesthetized patients were placed in lateral decubitus. Cone‐beam CT (CBCT) was performed, and the needle trajectory was planned using Syngo iGuide Needle Guidance. Metal hook‐wire or coil was placed, according to our workflow, close to the lesion and their position was verified by CBCT or fluoroscopy. Results: Eleven VATS wedge resections were performed in 10 patients with 12 non‐palpable lesions. The localization was performed with seven hook‐wires and four coils in 30 minutes (range 17‐56 minutes). The median estimated total effective dose was 11.6 mSv (range 1.9‐24.7 mSv). Eleven lesions were removed by VATS, and one deep nodule required a thoracotomy. No complications were observed. Conclusions: Our experience confirms that HOR is suitable for simultaneous localization and VATS resection of ‘difficult’ pulmonary lesions. A versatile approach, using different devices, seems advisable for the removal of targets in every clinical scenario, reducing the VATS conversion rate. [ABSTRACT FROM AUTHOR]

Published
2018
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