28 results on '"Mellnick V"'
Search Results
2. Imaging features of marginal ulcers on multidetector CT
- Author
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Zulfiqar, M., primary, Ludwig, D.R., additional, Strnad, B., additional, McVay, M., additional, Rengarajan, A., additional, Kushnir, V., additional, and Mellnick, V., additional
- Published
- 2023
- Full Text
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3. Bile Leak Detection after HPB Surgery Using Eovist Enhanced MRI Protocols: Is There Still a Diagnostic Role for HIDA Scans?
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Ahmed, O., primary, Lee, A., additional, Vachharajani, N., additional, Chang, S.-H., additional, Park, Y., additional, Khan, A., additional, Chapman, W., additional, Mellnick, V., additional, and Doyle, M., additional
- Published
- 2022
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4. Extramedullary haematopoiesis: radiological imaging features.
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Roberts, A. S., Shetty, A. S., Mellnick, V. M., Pickhardt, P. J., Bhalla, S., and Menias, C. O.
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BLOOD cells , *BONE marrow , *THALASSEMIA , *SICKLE cell anemia , *RADIOLOGISTS , *HEMORRHAGE - Abstract
Extramedullary haematopoiesis (EMH) is defined as the production of blood cells outside of the bone marrow, which occurs when there is inadequate production of blood cells. The most common causes of EMH are myelofibrosis, diffuse osseous metastatic disease replacing the bone marrow, leukaemia, sickle cell disease, and thalassemia. The purpose of this article is to review the common and uncommon imaging appearances of EMH by anatomical compartment. In the thorax, EMH most commonly presents as paravertebral fat-containing masses, and typically does not present a diagnostic dilemma; however, EMH in the abdomen most commonly manifests as hepatosplenomegaly with or without focal soft-tissue masses in the liver, spleen, perirenal space, and in the peritoneum. Hepatosplenomegaly, a non-specific feature, most often occurs without an associated focal mass, which makes suggestion of EMH difficult. EMH manifesting as visceral soft-tissue masses often requires biopsy as the differential diagnosis can include lymphoma, metastatic disease, and sarcoma. Many of these soft-tissue masses do not contain adipose elements, making the diagnosis of EMH difficult. Clinical history is crucial, as EMH would likely not otherwise be in the differential in patients with non-specific abdominal masses. Careful biopsy planning is necessary when EMH is a diagnostic consideration, given the propensity for haemorrhage. Understanding the typical imaging appearances of EMH based on its site of manifestation can help the radiologist when encountered with a finding that is diagnostic for EMH, and can help the radiologist suggest the need and plan appropriately for image-guided biopsy. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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5. Abdominal CT findings characteristic of Castleman disease: multi-centre review of 76 adult cases with abdominopelvic nodal involvement.
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Pickhardt PJ, Wong VK, Mellnick V, Sugi M, and Aswani Y
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- Humans, Female, Adult, Male, Retrospective Studies, Middle Aged, Lymph Nodes diagnostic imaging, Lymph Nodes pathology, Radiography, Abdominal methods, Pelvis diagnostic imaging, Aged, Castleman Disease diagnostic imaging, Castleman Disease pathology, Tomography, X-Ray Computed methods
- Abstract
Objective: Characterize the CT findings of abdominopelvic Castleman disease, including a new observation involving the perinodal fat., Methods: Multi-centre search at 5 institutions yielded 76 adults (mean age, 42.1 ± 14.3 years; 38 women/38 men) meeting inclusion criteria of histopathologically proven Castleman disease with nodal involvement at abdominopelvic CT. Retrospective review of the dominant nodal mass was assessed for size, attenuation, and presence of calcification, and for prominence and soft-tissue infiltration of the perinodal fat. Hypervascular nodal enhancement was based on both subjective and objective comparison with aortic blood pool attenuation., Results: Abdominal involvement was unicentric in 48.7% (37/76) and multicentric in 51.3% (39/76), including 31 cases with extra-abdominal involvement. Histopathologic subtypes included hyaline vascular variant (HVV), plasma cell variant (PCV), mixed HVV/PCV, and HHV-8 variant in 39, 25, 3 and 9 cases, respectively. The dominant nodal mass measured 4.4 ± 1.9 cm and 3.2 ± 1.7 cm in mean long- and short-axis, respectively, and appeared hypervascular in 58.6% (41/70 with IV contrast). Internal calcification was seen in 22.4% (17/76). Infiltration of the perinodal fat, with or without hypertrophy, was present in 56.6% (43/76), more frequent with hypervascular vs non-hypervascular nodal masses (80.5% vs 20.7%; P < .001). Among HVV cases, 76.9% were unicentric, 71.1% appeared hypervascular, and 69.2% demonstrated perinodal fat infiltration., Conclusion: Hypervascular nodal masses demonstrating prominence and infiltration of perinodal fat at CT can suggest the specific diagnosis of Castleman disease, especially the HVV., Advances in Knowledge: Abdominopelvic nodal masses that demonstrate hypervascular enhancement and prominent infiltration of the perinodal fat at CT can suggest the diagnosis of Castleman disease, but nonetheless requires tissue sampling., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology.)
- Published
- 2024
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6. Pearls and Pitfalls of Imaging Small Bowel Obstruction.
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Feister K, Konstantinoff K, Hamade M, and Mellnick V
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- Humans, Female, Magnetic Resonance Imaging methods, Pregnancy, Tomography, X-Ray Computed methods, Diagnostic Imaging methods, Contrast Media, Intestinal Obstruction diagnostic imaging, Intestine, Small diagnostic imaging
- Abstract
Small bowel obstruction (SBO) is a common condition encountered by radiologists in the evaluation of patients with abdominal pain, and is an important diagnosis to be comfortable with given substantial associated morbidity and mortality. In this review, we summarize an imaging approach to evaluating patients with suspected SBO, discuss the role of certain imaging modalities such as radiography and small bowel follow through, CT, and MRI, as well as review some common and also less common causes of SBO such as internal hernia. We will also discuss tailoring the imaging approach to address specific clinical questions and special patient populations such as imaging the pregnant patient with suspected SBO, and the inflammatory bowel disease patient., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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7. Bowel Emergencies in Patients With Cancer.
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Hughes H, Jajodia A, Soyer P, Mellnick V, and Patlas MN
- Abstract
Cancer is the second most common cause of death worldwide. Bowel emergencies in patients with cancer are becoming increasingly more prevalent due to advances in cancer therapy and longer overall patient survival. When these patients present acutely, they are often frail and may have pre-existing co-morbidities. This article discusses the imaging features of bowel emergencies commonly encountered in oncological patients in clinical practice. These include chemotherapy related colitis, neutropenia enterocolitis and typhlitis, toxic megacolon, bowel perforation, malignant bowel obstruction and gastrointestinal haemorrhage. The radiologist plays a key role in identifying these oncological emergencies and guiding further management., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: H.H. is the Editor-in-Training of Canadian Association of Radiologists Journal. M.N.P. is the Editor-in-Chief of Canadian Association of Radiologists Journal.
- Published
- 2024
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8. ACR Appropriateness Criteria® Left Lower Quadrant Pain: 2023 Update.
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Weinstein S, Kim DH, Fowler KJ, Birkholz JH, Cash BD, Cilenti E, Dane B, Horvat N, Kambadakone AR, Korngold EK, Liu PS, Lo BM, McCrary M, Mellnick V, Pietryga JA, Santillan CS, Zukotynski K, and Carucci LR
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- Humans, Abdominal Pain, Diagnostic Imaging, Evidence-Based Medicine, United States, Diverticulitis, Societies, Medical
- Abstract
The differential diagnosis for left lower quadrant pain is wide and conditions range from the benign and self-limited to life-threatening surgical emergencies. Along with patient history, physical examination, and laboratory tests, imaging is often critical to limit the differential diagnosis and identify life-threatening abnormalities. This document will discuss the guidelines for the appropriate use of imaging in the initial workup for patients who present with left lower quadrant pain, patients with suspected diverticulitis, and patients with suspected complications from diverticulitis. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision process support the systematic analysis of the medical literature from peer reviewed journals. Established methodology principles such as Grading of Recommendations Assessment, Development, and Evaluation or GRADE are adapted to evaluate the evidence. The RAND/UCLA Appropriateness Method User Manual provides the methodology to determine the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where peer reviewed literature is lacking or equivocal, experts may be the primary evidentiary source available to formulate a recommendation., (Copyright © 2023 American College of Radiology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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9. Contrast-Enhanced Ultrasound for Image-Guided Procedures.
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Russell G, Strnad BS, Ludwig DR, Middleton WD, Itani M, Khot R, Mellnick V, and Malone C
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- Humans, Ultrasonography methods, Magnetic Resonance Imaging, Tomography, X-Ray Computed, Contrast Media, Liver Neoplasms pathology
- Abstract
Contrast-enhanced ultrasound (CEUS) uses intravenously injected gas microbubbles as a pure blood pool contrast agent to demonstrate blood flow and tissue perfusion at a much higher sensitivity than color Doppler and power Doppler ultrasound. CEUS has gained traction in abdominal diagnostic imaging for improved lesion detection and characterization and a complementary problem-solving tool to CT and MRI. In addition to its diagnostic applications, CEUS has also proven useful for pre-procedure planning, procedure guidance, and post-procedure evaluation. This review provides a practical overview and guides to the application of CEUS in percutaneous, ultrasound-guided, needle-driven procedures, focusing on 2 common procedures, which illustrate the many benefits of CEUS- core needle biopsy (CNB) and percutaneous hepatic lesion ablation., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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10. Subcutaneous and visceral fat are associated with worse outcomes in gunshot injuries but not stab injuries to the torso.
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Mejias C, Hoegger M, Snyder J, Raptis C, and Mellnick V
- Abstract
Purpose: The effect of obesity in penetrating trauma outcomes is poorly understood. The purpose of this study was to determine if there is a protective effect of subcutaneous or visceral fat from stab and gunshot wounds., Methods: 443 patients admitted after penetrating traumatic injury of the torso were retrospectively identified from our institution's trauma registry. CT scans performed at presentation were used to determine cross-sectional area of visceral and subcutaneous fat at the level of the umbilicus via manual segmentation. Obesity-associated parameters including body mass index, visceral and subcutaneous fat were compared with injury severity score, length of hospital/intesive care unit (ICU) stay, and number of operating room (OR) visits. Parameters were compared between patients who sustained stab wounds versus gunshot injuries., Results: Comparing all patients with gunshot injuries with those with stab injuries, gunshots resulted in increased hospital and ICU length of stay, and injury severity score (ISS). For patients with gunshot wounds, all obesity-related parameters correlated with increased length of stay and total ICU stay; subcutaneous fat and visceral fat were correlated with increased OR visits, but there was no significant correlation between obesity-related parameters and ISS. In contrast, with stab wounds there were no statistically significant associations between obesity parameters and any of the outcome measures., Conclusion: For penetrating trauma in the torso, obesity is correlated with worse outcomes with gunshot injuries but not in stab injuries., Level of Evidence: Level III, prognostic and epidemiological., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
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11. Multimodality Imaging of Hamartomas: Interactive Case-based Approach.
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Lee MH, Lubner MG, Kennedy TA, Ross A, Gegios A, Mellnick V, Bhalla S, Buehler D, and Pickhardt PJ
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- Humans, Multimodal Imaging, Hamartoma diagnostic imaging
- Published
- 2023
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12. Vascular Anomaly Syndromes in the ISSVA Classification System: Imaging Findings and Role of Interventional Radiology in Management.
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Wang MX, Kamel S, Elsayes KM, Guillerman RP, Habiba A, Heng L, Revzin M, Mellnick V, Iacobas I, and Chau A
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- Adult, Child, Humans, Radiology, Interventional, Hemangioma, Klippel-Trenaunay-Weber Syndrome diagnostic imaging, Klippel-Trenaunay-Weber Syndrome therapy, Musculoskeletal Abnormalities, Vascular Malformations diagnostic imaging, Vascular Malformations therapy
- Abstract
Vascular anomalies encompass a spectrum of tumors and malformations that can cause significant morbidity and mortality in children and adults. Use of the International Society for the Study of Vascular Anomalies (ISSVA) classification system is strongly recommended for consistency. Vascular anomalies can occur in isolation or in association with clinical syndromes that involve complex multifocal lesions affecting different organ systems. Thus, it is critical to be familiar with the differences and similarities among vascular anomalies to guide selection of the appropriate imaging studies and possible interventions. Syndromes associated with simple vascular malformations include hereditary hemorrhagic telangiectasia, blue rubber bleb nevus syndrome, Gorham-Stout disease, and primary lymphedema. Syndromes categorized as vascular malformations associated with other anomalies include Klippel-Trenaunay-Weber syndrome, Parkes Weber syndrome, Servelle-Martorell syndrome, Maffucci syndrome, macrocephaly-capillary malformation, CLOVES ( c ongenital l ipomatous o vergrowth, v ascular malformations, e pidermal nevi, and s coliosis, skeletal, and spinal anomalies ) syndrome, Proteus syndrome, Bannayan-Riley-Ruvalcaba syndrome, and CLAPO ( c apillary malformations of the lower lip, l ymphatic malformations of the face and neck, a symmetry of the face and limbs, and p artial or generalized o vergrowth) syndrome. With PHACES ( p osterior fossa malformations, h emangiomas, a rterial anomalies, c ardiac defects and/or coarctation of the aorta, e ye abnormalities, and s ternal clefting or supraumbilical raphe) syndrome, infantile hemangiomas associated with other lesions occur. Diagnostic and interventional radiologists have important roles in diagnosing these conditions and administering image-guided therapies-embolization and sclerotherapy, and different ablation procedures in particular. The key imaging features of vascular anomaly syndromes based on the 2018 ISSVA classification system and the role of interventional radiology in the management of these syndromes are reviewed. Online supplemental material is available for this article.
© RSNA, 2022.- Published
- 2022
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13. Prognostic Value of Water-Soluble Contrast Challenge for Nonadhesive Small Bowel Obstruction.
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Hunter Lanier M, Ludwig DR, Ilahi O, and Mellnick V
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- Aged, Contrast Media, Female, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Tissue Adhesions etiology, Treatment Outcome, Water, Intestinal Obstruction etiology, Intestinal Obstruction therapy
- Abstract
Background: There is little evidence supporting the use of a water-soluble contrast challenge (WSCC) for conservative management of nonadhesive small bowel obstruction (NASBO). Our objective was to evaluate the prognostic value of the WSCC in a diverse group of patients with NASBO in comparison with patients with adhesive small bowel obstruction (ASBO)., Study Design: Retrospective chart review of patients with ASBO or NASBO who underwent a WSCC during a 4-year time period was performed. The primary study endpoint was any intervention for small bowel obstruction during the initial admission or within 30 days of discharge., Results: A total of 106 patients were included, 53 with ASBO (mean age 64 ± 13 years [SD]; 55% women) and 53 with NASBO (mean age 59 ± 13 years [SD]; 57% women). A higher rate of interventions during admission or within 30 days of discharge was seen in patients with NASBO compared with ASBO (24/53 [45%] vs 12/53 [23%]; p = 0.01), including those with colonic transit times of less than 36 hours (14/41 [34%] vs 5/43 [12%]; p = 0.01). Using multivariate analysis, transit time greater than 36 hours remained an independent predictor of an intervention during admission or within 30 days of discharge (p < 0.001, odds ratio 19.0), after controlling for the type of small bowel obstruction., Conclusions: A majority of patients with NASBO were successfully managed conservatively during a 30-day period, supporting the use of WSCC in patients with NASBO; however, patients with NASBO had a higher rate of interventions during admission or within 30 days of discharge., (Copyright © 2022 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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14. Imaging Spectrum of Infections in the Setting of Immunotherapy and Molecular Targeted Therapy.
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Zulfiqar M, Menias C, Shetty A, Ludwig DR, Rehman SSU, Orlowski H, and Mellnick V
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- Humans, Immunotherapy adverse effects, Molecular Targeted Therapy, Quality of Life, Neoplasms diagnostic imaging, Neoplasms therapy, Opportunistic Infections
- Abstract
Advances in genomics and immunology are revolutionizing our understanding and treatment of cancer with improved treatment outcomes and patient quality of life. With the increasing use of immunotherapy and molecular targeted therapy, a variety of unusual and/or opportunistic infections are also observed. A variety of factors including use of immunosuppression for immune-mediated adverse effects play an important role for increasing the likelihood of these infections and form the basis of this case-based review. Imaging features of infections arising in patients undergoing immunotherapy regimens have not been previously highlighted. Prompt recognition of the spectrum of mycobacterial, bacterial, invasive fungal and viral pathogens can potentially lead to reduction in the high morbidity and mortality in this patient population., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2022
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15. Human Gut Microbiota-associated Gastrointestinal Malignancies: A Comprehensive Review.
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Bonde A, Daly S, Kirsten J, Kondapaneni S, Mellnick V, Menias CO, and Katabathina VS
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- Ecosystem, Herpesvirus 4, Human, Humans, Epstein-Barr Virus Infections, Gastrointestinal Microbiome, Gastrointestinal Neoplasms
- Abstract
The human gastrointestinal tract houses trillions of microbes. The gut and various types of microorganisms, including bacteria, viruses, fungi, and archaea, form a complex ecosystem known as the gut microbiota, and the whole genome of the gut microbiota is referred to as the gut microbiome. The gut microbiota is essential for homeostasis and the overall well-being of a person and is increasingly considered an adjunct "virtual organ," with a complexity level comparable to that of the other organ systems. The gut microbiota plays an essential role in nutrition, local mucosal homeostasis, inflammation, and the mucosal immune system. An imbalanced state of the gut microbiota, known as dysbiosis, can predispose to development of various gastrointestinal malignancies through three speculated pathogenic mechanisms: (a) direct cytotoxic effects with damage to the host DNA, (b) disproportionate proinflammatory signaling inducing inflammation, and (c) activation of tumorigenic pathways or suppression of tumor-suppressing pathways. Several microorganisms, including Helicobacter pylori , Epstein-Barr virus, human papillomavirus, Mycoplasma species , Escherichia coli , and Streptococcus bovis , are associated with gastrointestinal malignancies such as esophageal adenocarcinoma, gastric adenocarcinoma, gastric mucosa-associated lymphoid tissue lymphoma, colorectal adenocarcinoma, and anal squamous cell carcinoma. Imaging plays a pivotal role in diagnosis and management of microbiota-associated gastrointestinal malignancies. Appropriate use of probiotics, fecal microbiota transplantation, and overall promotion of the healthy gut are ongoing areas of research for prevention and treatment of malignancies. Online supplemental material is available for this article.
© RSNA, 2021.- Published
- 2021
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16. Accuracy of Preoperative MDCT in Patients With Penetrating Abdominal and Pelvic Trauma.
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Ghumman Z, Monteiro S, Mellnick V, Coates A, Engels P, and Patlas M
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- Abdominal Injuries surgery, Adolescent, Adult, Aged, Diaphragm diagnostic imaging, Diaphragm injuries, Female, Gallbladder diagnostic imaging, Gallbladder injuries, Humans, Injury Severity Score, Intestines diagnostic imaging, Intestines injuries, Liver diagnostic imaging, Liver injuries, Male, Mesentery diagnostic imaging, Mesentery injuries, Middle Aged, Pelvis diagnostic imaging, Pelvis surgery, Preoperative Period, Retrospective Studies, Sensitivity and Specificity, Spleen diagnostic imaging, Spleen injuries, Wounds, Penetrating surgery, Young Adult, Abdominal Injuries diagnostic imaging, Digestive System diagnostic imaging, Digestive System injuries, Multidetector Computed Tomography, Pelvis injuries, Wounds, Penetrating diagnostic imaging
- Abstract
Purpose: This study aims to evaluate the overall diagnostic accuracy of preoperative multidetector computed tomography (MDCT) in penetrating abdominal and pelvic injuries (PAPI)., Method and Materials: We used our hospitals' trauma registry to retrospectively identify patients with PAPI from January 1, 2006, to December 31, 2016. Only patients who had a 64-MDCT scan at presentation and subsequently underwent laparotomy or laparoscopy were included in our study cohort. Each finding noted on MDCT was rated using a 5-point scale to indicate certainty of injury, with a score of 0 being definitive. Using surgical findings as the gold standard, the accuracy of radiology reports was analyzed in 2 ways. A κ statistic was calculated to evaluate each pair of values for absolute agreement, and ratings for all organ systems were analyzed using a repeated measures analysis of variance (ANOVA) to determine whether radiology and surgical findings were similar enough to be clinically meaningful. Qualitative review of the radiology and surgical reports focused on the gastrointestinal (GI) tract was conducted., Results: Our cohort consisted of 38 males and 4 females with a median age of 29 years and a median injury severity score of 15.6. For this study, 12 different organ groups were categorized and analyzed. Of those organ groups, absolute agreement between MDCT and surgical findings was found only for liver and spleen (κ values ranging from 0.2 to 0.5). Additionally, the ANOVA revealed an interaction between finding type and organ system ( F
1, 33 = 7.4, P < .001). The most clinically significant discrepancies between MDCT and surgical findings were for gallbladder, bowel, mesenteric, and diaphragmatic injuries. Qualitative review of the GI tract revealed that radiologists can detect significant findings such as presence of injury, however, localization and extent of injury pose a challenge., Conclusion: The detection of clinically significant injuries to solid organs in trauma patients with PAPI on 64-MDCT is adequate. However, detection of injury to the remaining organ groups on MDCT, especially bowel, mesentery, and diaphragm, remains a challenge.- Published
- 2020
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17. A 2019 international survey to assess trends in follow-up imaging of blunt splenic trauma.
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Odedra D, Mellnick V, and Patlas M
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- Female, Humans, Internationality, Male, Surveys and Questionnaires, Continuity of Patient Care trends, Diagnostic Imaging trends, Practice Patterns, Physicians' trends, Spleen injuries, Wounds, Nonpenetrating diagnostic imaging
- Abstract
Purpose: There are no published guidelines on the follow-up imaging of non-operatively managed blunt splenic trauma (BST). We conducted an international survey of emergency radiologists to determine the ideal patient population, time period, and technique for follow-up imaging of BST., Methods: An anonymous 10-question online survey was distributed via email to 34 emergency radiologists around the world. The survey was open for a 2-week period in 2019. A commercially available website (SurveyMonkey®) was used for survey generation and data acquisition., Results: We received 29 responses (85% response rate) primarily from USA, Canada, and Europe. Majority of the institutions handled > 1000 trauma cases (69%). The initial protocol consisted of arterial and portal venous phases (PVP) in 72% of responses. Sixty-two percent of the institutions did not have a routine protocol for follow-up imaging of BST. There was no consensus on which patients received follow-up imaging. The most frequent responses had been case-per-case basis or injuries above a set AAST grade (42% and 37%, respectively). There was no set time period for follow-up imaging, but MDCT was most often performed at 24-48 h. Dual-phase protocol was utilized most commonly (69%). Majority of the institutions (88%) utilized angioembolization for hemodynamically stable patients with contained vascular injury or active extravasation., Conclusion: There is no consensus on the optimal patient population or time period for follow-up imaging of BST. A dual-phase follow-up MDCT protocol is utilized for follow-up by majority of institutions.
- Published
- 2020
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18. The Clinical Impact of Resident-attending Discrepancies in On-call Radiology Reporting: A Retrospective Assessment.
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McWilliams SR, Smith C, Oweis Y, Mawad K, Raptis C, and Mellnick V
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- Abdomen diagnostic imaging, Diagnostic Errors, Humans, Observer Variation, Retrospective Studies, Thorax diagnostic imaging, Tomography, X-Ray Computed, Disease Management, Internship and Residency, Physicians, Radiology
- Abstract
Rationale and Objectives: The purpose of this study is to quantify the clinical impact of resident-attending discrepancies at a tertiary referral academic radiology residency program by assessing rates of intervention, discrepancy confirmation, recall rate, and management change rate; furthermore, a discrepancy categorization system will be assessed., Materials and Methods: Retrospective review of the records was performed for n = 1482 discrepancies that occurred in the 17-month study period to assess the clinical impact of discrepancies. Discrepancies were grouped according to a previously published classification system. Management changes were recorded and grouped by severity. The recall rate was estimated for discharged patients. Any confirmatory testing was reviewed to evaluate the accuracy of the discrepant report. Categorical variables were compared to the chi-square test., Results: The 1482 discrepancies led to management change in 661 cases (44.6%). The most common management change was follow-up imaging. Procedural interventions including surgery occurred in 50 cases (3.3%). The recall rate was 2.6%. Management changes were more severe with computed tomography examinations, inpatients, and when the discrepancy was in the chest and abdomen subspecialty. Also, management changes correlated with the discrepancy category assigned by the attending at the time of review., Conclusions: Resident-attending discrepancies do cause management changes in 44.6% of discrepancies (0.62% overall); the most frequent change is follow-up imaging. The discrepancy categorization assigned by the attending correlated with the severity of management change., (Copyright © 2018 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
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19. Single-Contrast CT for Detecting Bowel Injuries in Penetrating Abdominopelvic Trauma.
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Jawad H, Raptis C, Mintz A, Schuerer D, and Mellnick V
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- Abdominal Injuries surgery, Adolescent, Adult, Aged, Aged, 80 and over, Contrast Media, Emergency Service, Hospital, Female, Humans, Male, Middle Aged, Retrospective Studies, Sensitivity and Specificity, Wounds, Gunshot diagnostic imaging, Wounds, Gunshot surgery, Wounds, Penetrating surgery, Abdominal Injuries diagnostic imaging, Tomography, X-Ray Computed methods, Wounds, Penetrating diagnostic imaging
- Abstract
Objective: Many centers advocate use of triple-contrast (IV, oral, and rectal) CT for assessing hemodynamically stable patients with penetrating abdominopelvic trauma. Enteric contrast material has several disadvantages, leading our practice to pursue use of single-contrast (IV) CT. We conducted a retrospective review of electronic medical records at our institution to assess the accuracy of single-contrast CT for diagnosing bowel injuries in cases of penetrating abdominopelvic trauma., Materials and Methods: We retrospectively reviewed patients who presented to our emergency department between January 1, 2004, and March 1, 2014, with penetrating abdominopelvic trauma, underwent an abdominopelvic CT, and had surgery performed thereafter. We reviewed pertinent emergency department records for details regarding the site of injury, the number of injuries per patient, and the type of weapon used. We correlated CT reports with operative notes for presence and sites of bowel injury., Results: A total of 274 patients (median age, 27 years old) met our inclusion criteria; 77% had sustained gunshot wounds (GSWs). CT showed bowel injury in 173 cases; surgery revealed bowel injury in 162 cases. CT had 142 true-positive, 31 false-positive, 81 true-negative, and 20 false-negative cases, resulting in sensitivity of 88%, specificity of 72%, positive predictive value of 82%, and negative predictive value of 80% for detecting bowel injuries. CT had the highest sensitivity and specificity in patients with multiple GSWs (94% and 79%, respectively) and those with injuries to the stomach and rectum., Conclusion: Single-contrast CT can show bowel injuries in patients with penetrating abdominopelvic trauma with accuracy comparable with that reported for triple-contrast CT.
- Published
- 2018
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20. Imaging features of hepatic arterial and venous flow abnormalities.
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Mills A and Mellnick V
- Published
- 2018
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21. Radiogenomics of High-Grade Serous Ovarian Cancer: Multireader Multi-Institutional Study from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group.
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Vargas HA, Huang EP, Lakhman Y, Ippolito JE, Bhosale P, Mellnick V, Shinagare AB, Anello M, Kirby J, Fevrier-Sullivan B, Freymann J, Jaffe CC, and Sala E
- Subjects
- Female, Humans, Middle Aged, Ovarian Neoplasms epidemiology, Retrospective Studies, Genomics methods, Ovarian Neoplasms diagnostic imaging, Ovarian Neoplasms genetics, Tomography, X-Ray Computed methods
- Abstract
Purpose To evaluate interradiologist agreement on assessments of computed tomography (CT) imaging features of high-grade serous ovarian cancer (HGSOC), to assess their associations with time-to-disease progression (TTP) and HGSOC transcriptomic profiles (Classification of Ovarian Cancer [CLOVAR]), and to develop an imaging-based risk score system to predict TTP and CLOVAR profiles. Materials and Methods This study was a multireader, multi-institutional, institutional review board-approved, HIPAA-compliant retrospective analysis of 92 patients with HGSOC (median age, 61 years) with abdominopelvic CT before primary cytoreductive surgery available through the Cancer Imaging Archive. Eight radiologists from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group developed and independently recorded the following CT features: characteristics of primary ovarian mass(es), presence of definable mesenteric implants and infiltration, presence of other implants, presence and distribution of peritoneal spread, presence and size of pleural effusions and ascites, lymphadenopathy, and distant metastases. Interobserver agreement for CT features was assessed, as were univariate and multivariate associations with TTP and CLOVAR mesenchymal profile (worst prognosis). Results Interobserver agreement for some features was strong (eg, α = .78 for pleural effusion and ascites) but was lower for others (eg, α = .08 for intraparenchymal splenic metastases). Presence of peritoneal disease in the right upper quadrant (P = .0003), supradiaphragmatic lymphadenopathy (P = .0004), more peritoneal disease sites (P = .0006), and nonvisualization of a discrete ovarian mass (P = .0037) were associated with shorter TTP. More peritoneal disease sites (P = .0025) and presence of pouch of Douglas implants (P = .0045) were associated with CLOVAR mesenchymal profile. Combinations of imaging features contained predictive signal for TTP (concordance index = 0.658; P = .0006) and CLOVAR profile (mean squared deviation = 1.776; P = .0043). Conclusion These results provide some evidence of the clinical and biologic validity of these image features. Interobserver agreement is strong for some features, but could be improved for others.
© RSNA, 2017 Online supplemental material is available for this article.- Published
- 2017
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22. The red connection: a review of aortic and arterial fistulae with an emphasis on CT findings.
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Sipe A, McWilliams SR, Saling L, Raptis C, Mellnick V, and Bhalla S
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- Humans, Aortic Diseases diagnostic imaging, Bronchial Fistula diagnostic imaging, Esophageal Fistula diagnostic imaging, Intestinal Fistula diagnostic imaging, Tomography, X-Ray Computed, Ureteral Diseases diagnostic imaging, Vascular Fistula diagnostic imaging
- Abstract
Fistulae between the aorta and adjacent structures are a rare, emergent, and potentially life-threatening process. Most commonly, aortic fistulae arise secondarily as a complication of prior aortic surgery with fistulization to adjacent structures. Rarely, a primary fistula may arise from the aorta in the setting of a pre-existing aneurysm or from a mass, inflammation, or infection. Although the incidence of aortic fistulae remains low, the frequency continues to increase as aortic surgical interventions and post-surgical follow-up with imaging become more common. Computed tomography (CT) is the modality of choice in evaluating the patient with suspected aortic fistula because of its accessibility and short scan time. In addition, CT allows for more clear depiction of para-aortic or intra-aortic gas than ultrasound or magnetic resonance (MR). This gas may be the first clue of a fistula. Given the high mortality associated with aortic fistulae, familiarity with the imaging findings of the spectrum of aortic fistulae is essential knowledge in the emergency setting. This review will discuss the imaging appearance of aortic and arterial fistulae to the bronchi, esophagus, gastrointestinal tract, ureters, and veins on CT.
- Published
- 2017
- Full Text
- View/download PDF
23. Imaging of acute anorectal conditions with CT and MRI.
- Author
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Guniganti P, Lewis S, Rosen A, Connolly S, Raptis C, and Mellnick V
- Subjects
- Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Rectal Diseases diagnostic imaging, Tomography, X-Ray Computed
- Abstract
Anorectal disorders are a common cause of presentation to the emergency department (ED). While the most frequently encountered anorectal conditions, such as hemorrhoids and anal fissures, are relatively benign and do not require imaging for diagnosis or management, there are multiple potentially life threatening anorectal conditions for which imaging is an important component of evaluation, diagnosis, and management. Although computed tomography (CT) is the most commonly used imaging modality for evaluation of anorectal pathology in the ED, magnetic resonance imaging (MRI) has an increasingly important role in the detection, characterization and management of specific anorectal conditions. This pictorial essay will review the imaging anatomy of the anorectum, summarize imaging protocols, and discuss the clinical presentation, imaging appearance, and differential diagnosis of anorectal conditions that may present to the emergency department, including infectious, inflammatory, malignant and vascular conditions.
- Published
- 2017
- Full Text
- View/download PDF
24. Pancreatic Paraganglioma: A Case Report.
- Author
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Tumuluru S, Mellnick V, Doyle M, and Goyal B
- Abstract
Background: Paraganglionic neoplasms that originate in the adrenal medullas are referred to as pheochromocytomas, but if they arise from other paraganglia scattered throughout the body, they are referred to as paragangliomas. Pancreatic paragangliomas are an extremely rare entity as only 20 cases have been reported in the literature. They tend to be nonfunctional and typically occur in the fourth to fifth decade of life without a gender predilection. We describe in this study a case of a pancreatic paraganglioma and its CT appearance. Case Presentation: A 62-year-old woman undergoing presurgical evaluation for an olfactory groove meningioma resection was incidentally found to have a pancreatic mass. Multiple fine needle aspirations of the mass through endoscopic ultrasound yielded only atypical epithelial cells. The mass demonstrated avid enhancement on serial CTs with mild interval growth over a period of 5 years. No lymphadenopathy was ever found. The patient's complete blood count, complete metabolic panel, and plasma carcinoembryonic antigen levels were all within normal limits. Urine catecholamine metabolite levels were never checked as the patient demonstrated no symptoms of catecholamine excess. The patient underwent a laparoscopic distal pancreatectomy and splenectomy, and the mass was eventually diagnosed as a pancreatic paraganglioma through pathology. While the patient tolerated the surgery well, she did require a biliary sphincterotomy and placement of a pancreatic duct stent postoperatively for treatment of a pancreatic duct leak, which completely resolved. She showed no evidence of disease recurrence on multiple subsequent CTs and continues to do well. Conclusion: Pancreatic paragangliomas are usually incidentally discovered and typically demonstrate avid homogenous enhancement on contrast-enhanced CT or MR. Aggressive surgical resection is necessary to maximize the chances of disease-free survival. Pancreatic paragangliomas are similar histologically, whether benign or malignant, to paragangliomas that occur anywhere else in the body, with ∼70% in the abdomen and 30% in the chest., Competing Interests: No competing financial interests exist.
- Published
- 2016
- Full Text
- View/download PDF
25. On-Call Radiology Resident Discrepancies: Categorization by Patient Location and Severity.
- Author
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Mellnick V, Raptis C, McWilliams S, Picus D, and Wahl R
- Subjects
- Humans, Lost to Follow-Up, Observer Variation, Physician-Patient Relations, Radiology education, Retrospective Studies, Severity of Illness Index, After-Hours Care statistics & numerical data, Clinical Competence statistics & numerical data, Diagnostic Errors statistics & numerical data, Diagnostic Imaging statistics & numerical data, Internship and Residency statistics & numerical data, Radiology Department, Hospital standards, Workload statistics & numerical data
- Abstract
Purpose: To report discrepancy rates for examinations interpreted by on-call residents overall and by resident training level, and to describe a novel discrepancy classification system based on patient location and severity that facilitates recording of discrepancy data, helps ensure proper communication of report changes, and allows our radiology department to assume responsibility for contacting discharged patients with non-time-dependent results., Methods: A HIPAA-compliant, institutional review board-exempt review of two years (January 2013 to December 2014) of discrepancy data was retrospectively performed for total number of examination interpreted, discrepancy rates, resident training level, and discrepancy categories. Most common diagnoses and means of results communication for discharged patients were also recorded., Results: Radiology residents interpreted 153,420 examinations after hours and had 2169 discrepancies, for an overall discrepancy rate of 1.4%. Discrepancy rates for postgraduate year (PGY)-3, PGY-4, and PGY-5 residents were 1.31%, 1.65%, and 1.88%, respectively. The rate of critical discrepancies was extremely low (10/153,420 or 0.007%). A total of 502 patients (23.2% of all discrepancies) were discharged at the time their discrepancy was identified, 60% of whom had non-time-dependent discrepancies that were communicated by radiologists; 32.4% of these had addended results telephoned to a PCP, 43.4% had addended results telephoned to the patient, and the remaining 24.2% required a registered letter. Eight percent of patients with non-time-dependent findings were lost to follow-up., Conclusions: Our resident discrepancy rates were comparable to those published previously, with extremely low rates of critical discrepancies. Radiologists assumed responsibility for contacting the majority of discharged patients with discrepant results, a minority of whom were lost to follow-up., (Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
26. Imaging of tailgut cysts.
- Author
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Shetty AS, Loch R, Yoo N, Mellnick V, Fowler K, and Narra V
- Subjects
- Cysts congenital, Female, Hamartoma congenital, Humans, Magnetic Resonance Imaging, Male, Rectal Diseases congenital, Rectum abnormalities, Tomography, X-Ray Computed, Cysts diagnosis, Hamartoma diagnosis, Rectal Diseases diagnosis, Rectum pathology
- Abstract
Tailgut cysts are congenital lesions that arise from the primitive hindgut in the true embryonic tail but fail to regress during gestation. These lesions are rare and more frequently encountered later in life and more commonly in women, and are the most common primary retrorectal tumor. Tailgut cysts may be asymptomatic or cause rectal bleeding, pain, or symptoms related to mass effect on the rectum or bladder. Pathologically, tailgut cysts are typically multilocular, lined with a variety of epithelial cell types, and are most frequently benign. Imaging is the linchpin of diagnosis due risks associated with biopsy. The purpose of this pictorial review is to present the spectrum of imaging findings associated with tailgut cysts on CT and MRI with focus on the use of advanced MRI and diffusion-weighted imaging. We present case examples of tailgut cysts, their CT and MR imaging findings, and diagnostic and management considerations.
- Published
- 2015
- Full Text
- View/download PDF
27. Sports-related genitourinary trauma in the male athlete.
- Author
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Nicola R, Menias CO, Mellnick V, Bhalla S, Raptis C, and Siegel C
- Subjects
- Diagnosis, Differential, Humans, Injury Severity Score, Male, Athletic Injuries diagnosis, Diagnostic Imaging, Urogenital System injuries
- Abstract
Genitourinary trauma is infrequent with regard to sports-related injuries and is frequently overlooked in the acute setting because other life-threatening or serious injuries take precedence. Once the patient has been stabilized, the radiologist plays a key role in the diagnosis of genitourinary trauma. The most commonly injured genitourinary organ is the kidney followed by the bladder and the urethra. Therefore, one should be familiar with imaging signs of genitourinary trauma in the athletic patient in order for these patients to be triaged appropriately. This article is a review of the spectrum of genitourinary trauma caused by sports-related injuries.
- Published
- 2015
- Full Text
- View/download PDF
28. An overview of nuclear medicine studies for urgent and emergent indications.
- Author
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Jain R, Sharma A, Uliel L, Mellnick V, and McConathy J
- Subjects
- Emergencies, Emergency Service, Hospital, Humans, Nuclear Medicine organization & administration, Radiopharmaceuticals, Tomography, Emission-Computed methods
- Published
- 2014
- Full Text
- View/download PDF
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