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INTRODUÇÃO: A presença de desnutrição tem sido associada a inflamação e estresse oxidativo (EO) em pacientes em hemodiálise (HD) crônica. OBJETIVO: Verificar a associação entre marcadores do estado nutricional, incluindo a gordura corporal (GC), marcadores inflamatórios e de EO em pacientes em HD. MÉTODOS: Estudo transversal, realizado em 40 pacientes em HD. O estado nutricional foi avaliado por avaliação subjetiva global modificada (SGAm), equivalente protéico do aparecimento de nitrogênio total normalizado (PNAn), albumina sérica (Alb-s), índice de massa corporal (IMC), GC e massa corporal magra (MCM). Inflamação e EO foram avaliadas através da proteína C-reativa de alta sensibilidade (PCRas), interleucina-6 (IL-6), produtos protéicos de oxidação avançada (PPOA), 8-hidroxideoxiguanosina (8OHdG) e pentosidina, respectivamente. RESULTADOS: Trinta e sete por cento dos pacientes apresentavam algum grau de desnutrição avaliada pela SGAm. A mediana e variação da GC (kg) foram de 16,2 (5,3 - 36,7). Com relação aos marcadores inflamatórios e de EO, houve uma correlação positiva e significativa entre IMC e PCRas (R = 0,37; p = 0,02), GC e PCRas (R = 0,32; p = 0,04) e entre PCRas e IL-6 (R = 0,51; p = 0,0007). Correlação negativa foi encontrada entre Alb-s e PCRas (R = -0,31; p = 0,05). Apenas no sexo masculino, a PCRas apresentou relação com IMC (R = 0,54; p = 0,01) e com a GC (R = 0,52; p = 0,01). Nenhuma associação foi encontrada entre marcadores inflamatórios e de EO. CONCLUSÃO: Marcadores de desnutrição e de excesso de peso não foram correlacionados com EO. A associação da PCRas com IMC e GC somente no sexo masculino pode sugerir diferenças na resposta inflamatória entre os sexos. INTRODUCTION: The presence of malnutrition has been associated with inflammation and oxidative stress (OS) in patients on chronic hemodialysis (HD). OBJECTIVE: To assess the association between nutritional status markers, such as body fat (BF), markers of inflammation and of OS in patients on HD. METHODS: Cross-sectional study performed with 40 patients on HD. The nutritional status was evaluated by use of the modified subjective global assessment (SGAm), normalized total protein equivalent of nitrogen appearance (PNAn), serum albumin (Alb-s), body mass index (BMI), BF, and lean body mass (LBM). Inflammation and OS were assessed by use of highsensitivity protein C-reactive (HS-PCR), interleukin-6 (IL-6), advanced oxidation protein products (AOPP), 8-hydroxydeoxyguanosine (8OHdG), and pentosidine. RESULTS: Some degree of malnutrition was observed in 37% of the patients assessed through SGAm. Median and variation of BF (kg) were 16.2 and 5.3-36.7, respectively. Regarding the markers of inflammation and of OS, a positive and significant correlation was observed between BMI and HS-PCR (R = 0.37; p = 0.02), BF and HS-PCR (R = 0.32; p = 0.04), and between HS-PCR and IL-6 (R = 0.51; p = 0.0007). A negative correlation was found between Alb-s and HS-PCR (R = -0.31; p = 0.05). Only in males HS-PCR related to BMI (R = 0.54; p = 0.01) and to BF (R = 0.52; p = 0.01). No association was found between markers of inflammation and of OS. CONCLUSION: Markers of malnutrition and of overweight did not correlate with OS. The association of HS-PCR with BMI and BF only in the male sex may suggest differences in the inflammatory response between the sexes.

The presence of malnutrition has been associated with inflammation and oxidative stress (OS) in patients on chronic hemodialysis (HD).To assess the association between nutritional status markers, such as body fat (BF), markers of inflammation and of OS in patients on HD.Cross-sectional study performed with 40 patients on HD. The nutritional status was evaluated by use of the modified subjective global assessment (SGAm), normalized total protein equivalent of nitrogen appearance (PNAn), serum albumin (Alb-s), body mass index (BMI), BF, and lean body mass (LBM). Inflammation and OS were assessed by use of high sensitivity protein C-reactive (HS-PCR), interleukin-6 (IL-6), advanced oxidation protein products (AOPP), 8-hydroxydeoxyguanosine (8OHdG), and pentosidine.Some degree of malnutrition was observed in 37% of the patients assessed through SGAm. Median and variation of BF (kg) were 16.2 and 5.3-36.7, respectively. Regarding the markers of inflammation and of OS, a positive and significant correlation was observed between BMI and HS-PCR (R = 0.37; p = 0.02), BF and HS-PCR (R = 0.32; p = 0.04), and between HS-PCR and IL-6 (R = 0.51; p = 0.0007). A negative correlation was found between Alb-s and HS-PCR (R = -0.31; p = 0.05). Only in males HS-PCR related to BMI (R = 0.54; p = 0.01) and to BF (R = 0.52; p = 0.01). No association was found between markers of inflammation and of OS.Markers of malnutrition and of overweight did not correlate with OS. The association of HS-PCR with BMI and BF only in the male sex may suggest differences in the inflammatory response between the sexes.

Objective To study the effect of high doses of thiamine (250 mg/day) and pyridoxine (200 mg/day) supplementation on plasma levels of advanced glycation end products and other oxidative stress markers in hemodialysis patients. Design An interventional survey. Setting This study was conducted at an outpatient nephrology clinic. Intervention and Patients We performed a randomized placebo-controlled study over 8 weeks in 50 patients (53% men, age 52.9 ± 3.4 years) on regular hemodialysis. Main Outcome Measures The patients were divided into 2 groups of 25 patients in each arm. Before starting the study, the patients in both groups were matched by age, gender, inflammatory profile (plasma interleukin [IL]-6 and high-sensitivity C-reactive protein [hsCRP]), and nutritional status (subjective global assessment and protein nitrogen appearance). Results In all, 40 of 50 patients completed the study (19 patients in the vitamin group and 21 in the placebo group). Serum albumin, plasma hsCRP, IL-6, advanced oxidation protein products, pentosidine and 8-hydroxy-2′-deoxyguanosine were measured before and after treatment in each group. In both groups, over 8 weeks of follow-up, no significant differences could be observed in oxidative stress, inflammatory, or nutritional markers. Conclusions There was no evidence showing that high doses of thiamine and pyridoxine affects oxidative stress in hemodialysis patients.