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8. Contributors to Volume 4

Author

Auerbach, Anthony, primary, Baldwin, B.A., additional, Ballivet, M., additional, Bers, Donald M., additional, Bertrand, D., additional, Boiron, Françoise, additional, Bowers, Linda M., additional, Boyle, M.B., additional, Büschges, Ansgar, additional, Cassagne, Claude, additional, Chang, Fat-Chun Tony, additional, Connor, John A., additional, Cooper, E., additional, Delcomyn, Fred, additional, Weer, Paul De, additional, Ebenezer, I.S., additional, Fields, R. Douglas, additional, Fitzgerald, Sandra C., additional, Forsythe, Ian D., additional, Gadsby, David G., additional, Glossmann, Hartmut, additional, Heape, Anthony, additional, Henigman, F., additional, Hirashima, Naohide, additional, Horn, Richard, additional, Imaizumi, Yuji, additional, Isenberg, G., additional, Kaczmarek, L.K., additional, Kendrick, K.M., additional, Keung, Edmund C., additional, Kirino, Yutaka, additional, Kordaš, M., additional, Korn, Stephen J., additional, Krüger, J., additional, Martin, David, additional, Marty, Alain, additional, Mason, W.T., additional, Melik, Ziva, additional, Millar, Julian, additional, Muraki, Katsuhiko, additional, Nadler, J. Victor, additional, Neale, Elaine A., additional, Neil, James, additional, Nelson, Phillip G., additional, Peterec, D., additional, Rakowski, R.F., additional, Rungger, D., additional, Saito, Yoshiro, additional, Schmitz, Josef, additional, Shattock, Michael J., additional, Stamford, Jonathan A., additional, Stephenson, Robert S., additional, Striessnig, Jörg, additional, Taylor, W. Rowland, additional, Valera, S., additional, Wachtel, Ruth E., additional, Watanabe, Minoru, additional, Wendt-Gallitelli, M.F., additional, Wilkison, Douglas M., additional, Xiang, Zhigang, additional, Yu, Chang, additional, and Zorec, R., additional

Published
1991
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19. The effect of caffeine on cutaneous postocclusive reactive hyperaemia

Author

Tanja Princi, Ksenija Cankar, Vittorio Grill, Z. Melik, Melik, Ziva, Princi, Tanja, Grill, Vittorio, and Cankar, Ksenija

Subjects
Male, Adenosine, Physiology, Glycobiology, Blood Pressure, 030204 cardiovascular system & hematology, Vascular Medicine, Biochemistry, Coffee, Hyperaemia, chemistry.chemical_compound, 0302 clinical medicine, Heart Rate, Blood Flow, Medicine and Health Sciences, Medicine, Ingestion, 030212 general & internal medicine, Skin, Multidisciplinary, Nucleosides, Arteries, Glycosylamines, Body Fluids, Chemistry, Blood, Physical Sciences, Cardiology, Female, Anatomy, medicine.symptom, Caffeine, Research Article, medicine.drug, Adult, medicine.medical_specialty, Science, Myogenic contraction, Hyperemia, Beverages, 03 medical and health sciences, Alkaloids, Internal medicine, Heart rate, Humans, Arterial Pressure, Nutrition, business.industry, Chemical Compounds, Biology and Life Sciences, Blood flow, Diet, Blood pressure, chemistry, Cardiovascular Anatomy, Blood Vessels, Postocclusive Reactive Hyperaemia, Physiological Processes, business
Abstract

BackgroundCaffeine is reported to be the most widely used pharmacologically active substance. It causes mental stimulation and increases blood pressure. Acute systolic and diastolic blood pressure response to caffeine attenuates in the course of regular caffeine use; tolerance to cardiovascular responses develops in some people. For some hypertension-prone people coffee ingestion may be harmful, and for others it may be beneficial. The aim of our work was to evaluate the effect of caffeine on postocclusive reactive hyperaemia (PORH), a test of microvascular function, and at the same time to monitor the central effects of caffeine on blood pressure and heart rate.MethodsHeart rate, arterial pressure, and cutaneous laser-Doppler (LD) flux were monitored in 32 healthy volunteers (aged 25.2 ± 4.3 years) before and after they ingested 200 mg of caffeine. LD flux was measured on a finger at rest and after the release of an 8-minute occlusion of digital arteries above the place of LD flux measurement. All parameters obtained after the ingestion of caffeine were compared to the values obtained before caffeine and to the values obtained after a placebo.ResultsWe found slightly increased arterial pressure as well as decreased heart rate and resting LD flux (Dunnett's test, pConclusionsFrom the results, we can conclude that caffeine affects cutaneous microvascular function during rest and during a PORH response, and that it increases blood pressure and decreases heart rate.

Published
2019

20. Diazepam augments gender differences in cutaneous LD flux response to local cooling.

Author

Melik Z and Cankar K

Subjects
Adult, Drug Therapy, Combination, Female, Hemodynamics drug effects, Hemodynamics physiology, Humans, Male, Microcirculation drug effects, Prazosin pharmacology, Regional Blood Flow, Sex Factors, Skin blood supply, Skin Temperature physiology, Yohimbine pharmacology, Cold Temperature, Diazepam pharmacology, Laser-Doppler Flowmetry methods, Muscle Relaxants, Central pharmacology, Skin drug effects, Skin Temperature drug effects
Abstract

Cutaneous vasoconstriction in response to local cooling is normally greater in females than in males. Cold induces amplification of alpha2-adrenoceptor affinity for norepinephrine and increases reflex sympathetic thermoregulatory output. Benzodiazepines are drugs with very well-known binding to the central and peripheral benzodiazepine receptors. Besides these effects they decrease sympathetic output and as it was shown in the last decade they act synergistically with alpha-adrenoceptors. In the present study we tested the hypothesis that the benzodiazepine diazepam interacts with an alpha-adrenoceptor mechanism at the level of microcirculation. We measured laser-Doppler blood flux changes provoked by local cooling before and after oral application of a low dose of diazepam (5 mg) in 9 healthy males and in 11 healthy females with regular menstrual cycles. The results of our experiments show that in females there is a significant reduction (ANOVA, p < 0.05) in laser-Doppler flux during the first four minutes of cooling after taking of diazepam. In males, there is no significant difference in the responses to cold before and after an application of diazepam. Our results suggest that diazepam, in addition to its well-known effect on BZ receptors may also interact with alpha2C-adrenoceptors in the vessel wall during local cooling.

Published
2005
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