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114 results on '"Melhus, Hakan"'

5. Disentangling the genetics of lean mass

Author

Karasik, David, Zillikens, M Carola, Hsu, Yi-Hsiang, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Barroso, Inês, Bennett, David A, Bertram, Lars, Bochud, Murielle, Borecki, Ingrid B, Broer, Linda, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos-Obando, Natalia, Cauley, Jane A, Cawthon, Peggy M, Chambers, John C, Chen, Zhao, Cho, Nam H, Choi, Hyung Jin, Chou, Wen-Chi, Cummings, Steven R, de Groot, Lisette C P G M, De Jager, Phillip L, Demuth, Ilja, Diatchenko, Luda, Econs, Michael J, Eiriksdottir, Gudny, Enneman, Anke W, Eriksson, Joel, Eriksson, Johan G, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Gieger, Christian, Grallert, Harald, Gudnason, Vilmundur, Lenore, Launer J, Hayward, Caroline, Hofman, Albert, Homuth, Georg, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Johnson, Toby, Biffar, Reiner, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline S L, Koller, Daniel L, Kooner, Jaspal S, Kraus, William E, Kritchevsky, Stephen, Kutalik, Zoltán, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Lerch, Markus M, Lewis, Joshua R, Lill, Christina, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Livshits, Gregory, Ljunggren, Östen, Loos, Ruth J F, Lorentzon, Mattias, Luan, Jian'an, Luben, Robert N, Malkin, Ida, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Michaëlsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Nethander, Maria, Newman, Anne B, O'Connell, Jeffery R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Peacock, Munro, Perola, Markus, Peters, Annette, Prince, Richard L, Psaty, Bruce M, Räikkönen, Katri, Ralston, Stuart H, Ripatti, Samuli, Rivadeneira, Fernando, Robbins, John A, Rotter, Jerome I, Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schipf, Sabine, Shin, Chan Soo, Smith, Albert V, Smith, Shad B, Soranzo, Nicole, Spector, Timothy D, Stančáková, Alena, Stefansson, Kari, Steinhagen-Thiessen, Elisabeth, Stolk, Lisette, Streeten, Elizabeth A, Styrkarsdottir, Unnur, Swart, Karin M A, Thompson, Patricia, Thomson, Cynthia A, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J, Uitterlinden, André G, van Duijn, Cornelia M, van Schoor, Natasja M, Vandenput, Liesbeth, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, J Wareham, Nicholas, Waterworth, Dawn, Weedon, Michael N, Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M K, Wilson, James F, Wright, Nicole C, Yerges-Armstrong, Laura M, Yu, Lei, Zhang, Weihua, Zhao, Jing Hua, Zhou, Yanhua, Nielson, Carrie M, Harris, Tamara B, Demissie, Serkalem, Kiel, Douglas P, and Ohlsson, Claes

Published
2019
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9. Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

Author

Manousaki, Despoina, Dudding, Tom, Haworth, Simon, Hsu, Yi-Hsiang, Liu, Ching-Ti, Medina-Gómez, Carolina, Voortman, Trudy, van der Velde, Nathalie, Melhus, Håkan, Robinson-Cohen, Cassianne, Cousminer, Diana L., Nethander, Maria, Vandenput, Liesbeth, Noordam, Raymond, Forgetta, Vincenzo, Greenwood, Celia M.T., Biggs, Mary L., Psaty, Bruce M., Rotter, Jerome I., Zemel, Babette S., Mitchell, Jonathan A., Taylor, Bruce, Lorentzon, Mattias, Karlsson, Magnus, Jaddoe, Vincent V.W., Tiemeier, Henning, Campos-Obando, Natalia, Franco, Oscar H., Utterlinden, Andre G., Broer, Linda, van Schoor, Natasja M., Ham, Annelies C., Ikram, M. Arfan, Karasik, David, de Mutsert, Renée, Rosendaal, Frits R., den Heijer, Martin, Wang, Thomas J., Lind, Lars, Orwoll, Eric S., Mook-Kanamori, Dennis O., Michaëlsson, Karl, Kestenbaum, Bryan, Ohlsson, Claes, Mellström, Dan, de Groot, Lisette C.P.G.M., Grant, Struan F.A., Kiel, Douglas P., Zillikens, M. Carola, Rivadeneira, Fernando, Sawcer, Stephen, Timpson, Nicholas J., and Richards, J. Brent

Published
2017
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12. Risk factors for and preventability of drug-related hospital revisits in older patients: A post-hoc analysis of a randomized clinical trial

Author

Kempen, Thomas G. H., Hedman, Anton N., Hadziosmanovic, Nermin, Lindner, Karl-Johan, Melhus, Hakan, Nielsen, Elisabet I., Sulku, Johanna, Gillespie, Ulrika, Kempen, Thomas G. H., Hedman, Anton N., Hadziosmanovic, Nermin, Lindner, Karl-Johan, Melhus, Hakan, Nielsen, Elisabet I., Sulku, Johanna, and Gillespie, Ulrika

Abstract

AimThe aims of this study were (1) to identify older patients risk factors for drug-related readmissions and (2) to assess the preventability of older patients drug-related revisits. MethodsPost hoc analysis of a randomized clinical trial with patients aged >= 65 years at eight wards within four hospitals in Sweden. (1) The primary outcome was risk factors for drug-related readmission within 12 months post-discharge. A Cox proportional hazards model was made with sociodemographic and clinical baseline characteristics. (2) Four hundred trial participants were randomly selected and their revisits (admissions and emergency department visits) were assessed to identify potentially preventable drug-related revisits, related diseases and causes. Results(1) Among 2637 patients (median age 81 years), 582 (22%) experienced a drug-related readmission within 12 months. Sixteen risk factors (hazard ratio >1, P < 0.05) related to age, previous hospital visits, medication use, multimorbidity and cardiovascular, liver, lung and peptic ulcer disease were identified. (2) The 400 patients experienced a total of 522 hospital revisits, of which 85 (16%) were potentially preventable drug-related revisits. The two most prevalent related diseases were heart failure (n = 24, 28%) and chronic obstructive pulmonary disease (n = 13, 15%). The two most prevalent causes were inadequate treatment (n = 23, 27%) and insufficient or no follow-up (n = 22, 26%). Conclusion(1) Risk factors for drug-related readmissions in older hospitalized patients were age, previous hospital visits, medication use and multiple diseases. (2) Potentially preventable drug-related hospital revisits are common and might be prevented through adequate pharmacotherapy and continuity of care in older patients with cardiovascular or lung disease., Funding Agencies|Geriatriska fonden; Landstinget Vastmanland [LTV-675921, LTV712341, LTV-736641, LTV-840112]; Region Uppsala [LUL-527721, LUL-614061, LUL-716201, LUL-821261]; Region Gavleborg [CFUG-658451, CFUG-698771]; Regionala Forskningsradet Uppsala/Orebro [RFR-555601, RFR-641791, RFR-735911]; Swedish Pharmacists Association; Thureus Fund for Geriatric Research; Riksforbundet HjartLung [FA2017:38, FA2018:43]

Published
2023
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14. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

Author

Vimaleswaran, Karani S, Cavadino, Alana, Berry, Diane J, Jorde, Rolf, Dieffenbach, Aida Karina, Lu, Chen, Alves, Alexessander Couto, Heerspink, Hiddo J Lambers, Tikkanen, Emmi, Eriksson, Joel, Wong, Andrew, Mangino, Massimo, Jablonski, Kathleen A, Nolte, Ilja M, Houston, Denise K, Ahluwalia, Tarunveer Singh, van der Most, Peter J, Pasko, Dorota, Zgaga, Lina, Thiering, Elisabeth, Vitart, Veronique, Fraser, Ross M, Huffman, Jennifer E, de Boer, Rudolf A, Schöttker, Ben, Saum, Kai-Uwe, McCarthy, Mark I, Dupuis, Josée, Herzig, Karl-Heinz, Sebert, Sylvain, Pouta, Anneli, Laitinen, Jaana, Kleber, Marcus E, Navis, Gerjan, Lorentzon, Mattias, Jameson, Karen, Arden, Nigel, Cooper, Jackie A, Acharya, Jayshree, Hardy, Rebecca, Raitakari, Olli, Ripatti, Samuli, Billings, Liana K, Lahti, Jari, Osmond, Clive, Penninx, Brenda W, Rejnmark, Lars, Lohman, Kurt K, Paternoster, Lavinia, Stolk, Ronald P, Hernandez, Dena G, Byberg, Liisa, Hagström, Emil, Melhus, Håkan, Ingelsson, Erik, Mellström, Dan, Ljunggren, Östen, Tzoulaki, Ioanna, McLachlan, Stela, Theodoratou, Evropi, Tiesler, Carla M T, Jula, Antti, Navarro, Pau, Wright, Alan F, Polasek, Ozren, Wilson, James F, Rudan, Igor, Salomaa, Veikko, Heinrich, Joachim, Campbell, Harry, Price, Jacqueline F, Karlsson, Magnus, Lind, Lars, Michaëlsson, Karl, Bandinelli, Stefania, Frayling, Timothy M, Hartman, Catharina A, Sørensen, Thorkild I A, Kritchevsky, Stephen B, Langdahl, Bente Lomholt, Eriksson, Johan G, Florez, Jose C, Spector, Tim D, Lehtimäki, Terho, Kuh, Diana, Humphries, Steve E, Cooper, Cyrus, Ohlsson, Claes, März, Winfried, de Borst, Martin H, Kumari, Meena, Kivimaki, Mika, Wang, Thomas J, Power, Chris, Brenner, Hermann, Grimnes, Guri, van der Harst, Pim, Snieder, Harold, Hingorani, Aroon D, Pilz, Stefan, Whittaker, John C, Järvelin, Marjo-Riitta, and Hyppönen, Elina

Published
2014
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17. Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States

Author

Arnold, Melina, Freisling, Heinz, Stolzenberg-Solomon, Rachael, Kee, Frank, O’Doherty, Mark George, Ordóñez-Mena, José Manuel, Wilsgaard, Tom, May, Anne Maria, Bueno-de-Mesquita, Hendrik Bas, Tjønneland, Anne, Orfanos, Philippos, Trichopoulou, Antonia, Boffetta, Paolo, Bray, Freddie, Jenab, Mazda, Soerjomataram, Isabelle, Baceviciene, Migle, Boer, Jolanda M. A., Drygas, Wojciech, Eriksson, Sture, Feskens, Edith, Gafarov, Valeriy, Gardiner, Julian, Hakansson, Niclas, Jansson, Jan-Hakan, Jousilahti, Pekka, Kampman, Ellen, Kontto, Jukka, Kubinova, Ruzena, Leenders, Max, Linneberg, Allan, Lochen, Maja-Lisa, Lorbeer, Roberto, Malyutina, Sofia, Mathiesen, Ellisiv B., Melhus, Hakan, Michaëlsson, Karl, Njolstad, Inger, Orsini, Nicola, Pająk, Andrzej, Pikhart, Hynek, Pisinger, Charlotta, Salomaa, Veikko, Sánchez, María-José, Sans, Susana, Schaan, Barbara, Schneider, Andrea, Siganos, Galatios, Söderberg, Stefan, Streppel, Martinette, Tamošiūnas, Abdonas, Veronesi, Giovanni, Veronesi, Giovanni, Wennberg, Patrik, and on behalf of the CHANCES consortium

Published
2016
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26. Cardiovascular diseases and risk of hip fracture

Author

Sennerby, Ulf, Melhus, Hakan, Gedeborg, Rolf, Byberg, Liisa, Garmo, Hans, Ahlbom, Anders, Pedersen, Nancy L., and Michaelsson, Karl

Subjects
Twins -- Genetic aspects, Twins -- Health aspects, Cardiovascular diseases -- Genetic aspects, Cardiovascular diseases -- Diagnosis, Cardiovascular diseases -- Risk factors, Hip joint -- Fractures, Hip joint -- Risk factors
Abstract

A study was conducted to evaluate the relationship between cardiovascular disease (CVD) and the risk of hip fractures among twins and the role of genetics and lifestyle factors on the association. Results indicated that a diagnosis of CVD was significantly associated with a risk of such fractures and genetics also played an important role in it.

Published
2009

27. Type I collagen (alpha) 1 sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations

Author

Khoschnau, Shwan, Melhus, Hakan, Jacobson, Annica, Rahme, Hans, Bengtsson, Henrik, Ribom, Eva, Grundberg, Elin, Mallmin, Hans, and Michaelsson, Karl

Subjects
Cruciate ligaments -- Injuries, Collagen -- Genetic aspects, Collagen -- Research, Genetic polymorphisms -- Research, Shoulder joint -- Dislocation, Shoulder joint -- Risk factors, Shoulder joint -- Genetic aspects, Shoulder joint -- Research, Health, Sports and fitness
Published
2008

28. Leisure physical activity and the risk of fracture in men

Author

Michaelsson, Karl, Olofsson, Helena, Jensevik, Karin, Larsson, Sune, Mallmin, Hans, Berglund, Lars, Vessby, Bengt, and Melhus, Hakan

Subjects
Prevention, Injuries, Risk factors, Surveys, Demographic aspects, Causes of, Men -- Injuries -- Surveys, Fractures (Injuries) -- Causes of -- Demographic aspects -- Prevention -- Risk factors, Exercise -- Risk factors -- Surveys, Exercise for men -- Injuries -- Surveys, Fractures -- Causes of -- Demographic aspects -- Prevention -- Risk factors
Abstract

Background Data from previous studies are inconsistent, and it is therefore uncertain whether, to what extent, and at what level leisure physical activity influences the risk of osteoporotic fractures in [...]

Published
2007

29. Using genotyping to predict responses to anti-hypertensive treatment

Author

Kurland, Lisa, Lind, Lars, and Melhus, Hakan

Subjects
Hypertension -- Care and treatment, Hypertension -- Genetic aspects, Genotype -- Observations, Molecular biology -- Research, Biological sciences, Chemistry, Pharmaceuticals and cosmetics industries
Abstract

Hypertension is prevalent and affects ~ 1 in every 4 adults in the Western world. Although many drugs are effective in treating hypertension, an individual's response to treatment is unpredictable. Pharmacogenetics holds the promise of becoming a tool to predict this response but obstacles and shortcomings need to be overcome. Significant developments in molecular biology, including the sequencing of the genome, the cataloguing of genetic variation and the development of microarray techniques, enable analysis of many genotypes simultaneously. However, despite these technical advances there are, as yet, no clinical applications of pharmacogenetics in anti-hypertensive treatment. It is therefore necessary to design prospective pharmacogenetic studies that aim to identify a genetic profile that will predict the response to anti-hypertensive treatment.

Published
2005

31. Serum retinol levels and the risk of fracture

Author

Michaelsson, Karl, Lithell, Hans, Vessby, Bengt, and Melhus, Hakan

Subjects
Vitamin A -- Adverse and side effects, Fractures -- Risk factors
Abstract

Too much vitamin A can increase a person's risk of bone fracture, according to a study of 2,322 men. Men with the highest blood levels of vitamin A had 7 times the risk of fracturing a bone compared to men with the lowest blood levels. On the other hand, beta carotene was not associated with an increased risk of bone fracture.

Published
2003

32. Population density and mortality among individuals in motor vehicle crashes

Author

Gedeborg, Rolf, Thiblin, Ingemar, Byberg, Liisa, Melhus, Hakan, Lindback, Johan, and Michaelsson, Karl

Subjects
Traffic accidents -- Research, Emergency medical services -- Research, Population density -- Influence, Population density -- Research, Mortality -- Sweden, Mortality -- Research, Health
Published
2010

33. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial

Author

Gillespie, Ulrika, Alassaad, Anna, Henrohn, Dan, Garmo, Hans, Hammarlund-Udenaes, Margareta, Toss, Henrik, Kettis-Lindblad, Asa, Melhus, Hakan, and Morlin, Claes

Subjects
Pharmacists -- Influence, Pharmacists -- Research, Outcome and process assessment (Health Care) -- Demographic aspects, Outcome and process assessment (Health Care) -- Research, Morbidity -- Demographic aspects, Morbidity -- Research, Aged -- Health aspects, Aged -- Research, Medical care, Cost of -- Research, Health
Published
2009

36. Genetic liability to fractures in the elderly

Author

Michaelsson, Karl, Melhus, Hakan, Ferm, Helene, Ahlbom, Anders, and Pedersen, Nancy L.

Subjects
Fractures -- Genetic aspects, Osteoporosis -- Genetic aspects, Gene expression -- Influence, Aged -- Injuries, Health
Published
2005

41. Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis (vol 101, pg 227, 2017)

Author

Manousaki, Despoina, Dudding, Tom, Haworth, Simon, Hsu, Yi-Hsiang, Liu, Ching-Ti, Medina-Gomez, Carolina, Voortman, Trudy, van der Velde, Nathalie, Melhus, Hakan, Robinson-Cohen, Cassianne, Cousminer, Diana L., Nethander, Maria, Vandenput, Liesbeth, Noordam, Raymond, Forgetta, Vincenzo, Greenwood, Celia M. T., Biggs, Mary L., Psaty, Bruce M., Rotter, Jerome I., Zemel, Babette S., Mitchell, Jonathan A., Taylor, Bruce, Lorentzon, Mattias, Karlsson, Magnus, Jaddoe, Vincent V. W., Tiemeier, Henning, Campos-Obando, Natalia, Franco, Oscar H., Utterlinden, Andre G., Broer, Linda, van Schoor, Natasja M., Ham, Annelies C., Ikram, M. Arfan, Karasik, David, de Mutsert, Renee, Rosendaal, Frits R., den Heijer, Martin, Wang, Thomas J., Lind, Lars, Orwoll, Eric S., Mook-Kanamori, Dennis O., Michaelsson, Karl, Kestenbaum, Bryan, Ohlsson, Claes, Mellstrom, Dan, de Groot, Lisette C. P. G. M., Grant, Struan F. A., Kiel, Douglas P., Zillikens, M. Carola, Rivadeneira, Fernando, Sawcer, Stephen, Timpson, Nicholas J., Richards, J. Brent, General practice, APH - Aging & Later Life, Epidemiology and Data Science, Internal medicine, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Movement Sciences - Rehabilitation & Development, Amsterdam Movement Sciences - Restoration and Development, and APH - Personalized Medicine

Published
2018
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43. Dyslexia

Author

Melhus, Hakan

Published
1998

47. A Genome-Wide Association Study of Bisphosphonate-Associated Atypical Femoral Fracture

Author

Kharazmi, Mohammad, Michaelsson, Karl, Schilcher, Jörg, Eriksson, Niclas, Melhus, Hakan, Wadelius, Mia, Hallberg, Par, Kharazmi, Mohammad, Michaelsson, Karl, Schilcher, Jörg, Eriksson, Niclas, Melhus, Hakan, Wadelius, Mia, and Hallberg, Par

Abstract

Atypical femoral fracture is a well-documented adverse reaction to bisphosphonates. It is strongly related to duration of bisphosphonate use, and the risk declines rapidly after drug withdrawal. The mechanism behind bisphosphonate-associated atypical femoral fracture is unclear, but a genetic predisposition has been suggested. With the aim to identify common genetic variants that could be used for preemptive genetic testing, we performed a genome-wide association study. Cases were recruited mainly through reports of adverse drug reactions sent to the Swedish Medical Products Agency on a nation-wide basis. We compared atypical femoral fracture cases (n=51) with population-based controls (n=4891), and to reduce the possibility of confounding by indication, we also compared with bisphosphonate-treated controls without a current diagnosis of cancer (n=324). The total number of single-nucleotide polymorphisms after imputation was 7,585,874. A genome-wide significance threshold of pamp;lt;5x10(-8) was used to correct for multiple testing. In addition, we performed candidate gene analyses for a panel of 29 genes previously implicated in atypical femoral fractures (significance threshold of pamp;lt;5.7x10(-6)). Compared with population controls, bisphosphonate-associated atypical femoral fracture was associated with four isolated, uncommon single-nucleotide polymorphisms. When cases were compared with bisphosphonate-treated controls, no statistically significant genome-wide association remained. We conclude that the detected associations were either false positives or related to the underlying disease, i.e., treatment indication. Furthermore, there was no significant association with single-nucleotide polymorphisms in the 29 candidate genes. In conclusion, this study found no evidence of a common genetic predisposition for bisphosphonate-associated atypical femoral fracture. Further studies of larger sample size to identify possible weakly associated genetic traits, as well, Funding Agencies|Swedish Research Council [521-2011-2440, 521-2014-3370, 2015-03527]; Swedish Heart and Lung Foundation [20120557, 20140291, 20170711]; Selanders foundation; Thureus foundation; Swedish Medical Products Agency; Clinical Research Support (ALF) at Uppsala University; Ostergotland County Council [LIO-698411]; Science for Life Laboratory; Uppsala University; Research Council Swedish [2017-00641]; Swedish Research Council

Published
2019
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