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30 results on '"Melgarejo-Moreno, Antonio"'

5. Relation of New Permanent Right or Left Bundle Branch Block on Short- and Long-Term Mortality in Acute Myocardial Infarction Bundle Branch Block and Myocardial Infarction

Author

Melgarejo-Moreno, Antonio, Galcerá-Tomás, José, Consuegra-Sánchez, Luciano, Alonso-Fernández, Nuria, Díaz-Pastor, Ángela, Escudero-García, Germán, Jaulent-Huertas, Leticia, Vicente-Gilabert, Marta, Galcerá-Jornet, Emilio, Padilla-Serrano, Antonio, de Gea-García, José, and Pinar-Bermudez, Eduardo

Published
2015
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10. Female Sex Is Inversely and Independently Associated With Marked ST-Segment Elevation. A Study in Patients With ST-Segment Elevation Acute Myocardial Infarction and Early Admission

Author

Galcerá-Tomás, José, Melgarejo-Moreno, Antonio, Alonso-Fernández, Nuria, Padilla-Serrano, Antonio, Martínez-Hernández, Juan, Gil-Sánchez, Francisco J., del Rey-Carrión, Amparo, de Gea, José H., Rodríguez-García, Pascual, Martínez-Baño, Domingo, Jiménez-Sánchez, Roberto, Murcia-Hernández, Pilar, and del Saz, Ana

Published
2009
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11. El sexo femenino se asocia de forma inversa e independiente a la marcada elevación del segmento ST. Estudio en pacientes con infarto agudo de miocardio con ST elevado e ingreso precoz

Author

Galcerá-Tomás, José, Melgarejo-Moreno, Antonio, Alonso-Fernández, Nuria, Padilla-Serrano, Antonio, Martínez-Hernández, Juan, Gil-Sánchez, Francisco J., del Rey-Carrión, Amparo, de Gea, José H., Rodríguez-García, Pascual, Martínez-Baño, Domingo, Jiménez-Sánchez, Roberto, Murcia-Hernández, Pilar, and del Saz, Ana

Published
2009
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12. Association between new-onset right bundle branch block and primary or secondary ventricular fibrillation in ST-segment elevation myocardial infarction

Author

Galcerá-Jornet, Emilio, primary, Consuegra-Sánchez, Luciano, additional, Galcerá-Tomás, José, additional, Melgarejo-Moreno, Antonio, additional, Gimeno-Blanes, Juan Ramón, additional, Jaulent-Huertas, Leticia, additional, Wasniewski, Samantha, additional, de Gea-García, José, additional, Vicente-Gilabert, Marta, additional, and Padilla-Serrano, Antonio, additional

Published
2021
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23. Genotyping of six clopidogrel-metabolizing enzyme polymorphisms has a minor role in the assessment of platelet reactivity in patients with acute coronary syndrome.

Author

García-Lagunar, María Henar, Consuegra-Sánchez, Luciano, Conesa-Zamora, Pablo, Ruiz-Cosano, Javier, Arcos, Federico Soria, de Guadiana, Luis García, Vivar, Pedro Cano, Castillo-Moreno, Juan Antonio, and Melgarejo-Moreno, Antonio

Subjects
INPATIENT care, PSYCHOLOGY of the sick, APPLIED psychology, BEHAVIORAL medicine, CORONARY artery stenosis
Abstract

Objective: To evaluate the contribution of six polymorphisms to the platelet reactivity in patients with acute coronary syndrome (ACS) treated with clopidogrel. Methods: Cross-sectional study of 278 consecutive patients with ACS. Detailed clinical information for each patient was collected and genotypes (CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*17, CYP3A4*1B, and PON1-Q192R) were evaluated with TaqMan® and KASPar® assays. Platelet reactivity was measured with VerifyNow®. Results: Mean age of patients was 66±11 years and 182 (65.5%) patients presented ACS without ST-segment elevation. A total of 206 (74.1%) patients presented poor response to clopidogrel (PRC). CYP2C19*2 polymorphism (p=0.038) was associated with PRC in the univariate setting. In the multiple logistic regression analysis, the risk factors for PRC were the presence of CYP3A4*1B allele (odds ratio [OR] 4.03; 95% confidence interval [CI] 1.01-16.34), age (OR 1.43; 95% CI 1.03-2.00), and body mass index (OR 4.05; 95% CI 1.21-13.43), whereas elevated hemoglobin was a protective factor. Discrimination of PRC through the model that included the six polymorphisms added modest information to the model based on clinical variables (C statistic difference 3.9%). Conclusion: CYP3A4*1B allele may be an independent determinant of PRC in patients with ACS, although the variability in response to clopidogrel explained by the six polymorphisms is poor when compared to clinical variables. [ABSTRACT FROM AUTHOR]

Published
2017
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28. Pronóstico a corto y largo plazo de la fibrilación auricular previa y de novoen pacientes con infarto agudo de miocardio con elevación del segmento ST

Author

Consuegra-Sánchez, Luciano, Melgarejo-Moreno, Antonio, Galcerá-Tomás, José, Alonso-Fernández, Nuria, Díaz-Pastor, Ángela, Escudero-García, Germán, Jaulent-Huertas, Leticia, and Vicente-Gilabert, Marta

Abstract

El impacto de la fibrilación auricular en el pronóstico del infarto de miocardio sigue siendo controvertido. Se analizó la importancia pronóstica de la fibrilación auricular previa y de nueva aparición (de novo)en el hospital y a largo plazo en el infarto agudo de miocardio.

Published
2015
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30. [Prognostic importance of cardiomegaly in patients with acute myocardial infarction].

Author

Jaulent-Huertas L, Consuegra-Sánchez L, Vicente-Gilabert M, Melgarejo-Moreno A, Alonso-Fernández N, Díaz-Pastor A, Escudero-García G, and Galcerá-Tomás J

Abstract

Objectives: To assess the in-hospital and long-term prognostic importance of cardiomegaly demonstrated by a simple admission radiograph in patients hospitalized for acute myocardial infarction., Material and Methods: Prospective study of 7644 patients admitted for acute myocardial infarction; 2 hospitals participated. We recorded detailed clinical data, especially noting the presence or absence of cardiomegaly in the chest radiograph. Adjusted predictive models for all-cause mortality in hospital or after discharge were constructed. The median followup was 6 years., Results: Cardiomegaly was detected in 1351 (17.7%) of the patients. Hospital mortality was 11.2% overall; the incidence of long-term mortality was 5.7 per 100 patient-years. Patients with cardiomegaly were older and had more cardiovascular risk factors other than current smoking; they also had more concomitant conditions, had undergone fewer revascularization procedures, and received suboptimal care after discharge. Cardiomegaly was associated with higher in-hospital rates of adverse events, especially heart failure (70.8% in patients with cardiomegaly vs 21.4% in others, P<.001) and death (27.8% vs 7.7%, P<.001). Cardiomegaly was also an independent predictor of hospital mortality (odds ratio, 1.34; P=.02) as well as mortality after discharge (hazard ratio, 1.16; P<.01)., Conclusion: Cardiomegaly was an independent predictor of both hospital mortality and long-term mortality after discharge in this series.

Published
2015

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