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1. Association Between the First-Hour Intravenous Fluid Volume and Mortality in Pediatric Septic Shock

Author

Auletta, Jeffery J., Barchi, Katie, Braun, Benjamin R., Brilli, Richard J., Campbell, Deborah R., Chinnock, Richard E., Corboy, Jacqueline B., Depinet, Holly E., Dykstra-Nykanen, Jill, Genzel, Karen A., Hakim, Hana, Hron, Jonathan D., Hueschen, Leslie A., Huskins, W. Charles, Kandil, Sarah B., Kawai, Yu, Laurich, V. Matt, Loberger, Jeremy M., Macias, Charles G., Mackenzie, Joan E., Mack, Elizabeth H., Nagpal, Ashish S., Niedner, Matthew, Park, Daniel B., Razzaqi, Faisal, Redfern, Wendi S., Rosen, Johanna R., Rozenfeld, Ranna A., Selby, Sam, Sharron, Matthew P., Silverman, Jonathan A., Spack, Lawrence D., Stalets, Erika L., Thukaram, Roopa, Wathen, Beth A., Wilkes, Jennifer J., Workman, Jennifer K., Zuccaro, Jennifer C., Eisenberg, Matthew A., Riggs, Ruth, Paul, Raina, Balamuth, Fran, Richardson, Troy, DeSouza, Heidi G., Abbadesa, Mary Kate, DeMartini, Theodore K.M., Frizzola, Meg, Lane, Roni, Lloyd, Julia, Melendez, Elliot, Patankar, Nikhil, Rutman, Lori, Sebring, Amanda, Timmons, Zebulon, and Scott, Halden F.

Published
2022
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9. Association Between the First-Hour Intravenous Fluid Volume and Mortality in Pediatric Septic Shock

Author

Eisenberg, Matthew A., primary, Riggs, Ruth, additional, Paul, Raina, additional, Balamuth, Fran, additional, Richardson, Troy, additional, DeSouza, Heidi G., additional, Abbadesa, Mary Kate, additional, DeMartini, Theodore K.M., additional, Frizzola, Meg, additional, Lane, Roni, additional, Lloyd, Julia, additional, Melendez, Elliot, additional, Patankar, Nikhil, additional, Rutman, Lori, additional, Sebring, Amanda, additional, Timmons, Zebulon, additional, Scott, Halden F., additional, Auletta, Jeffery J., additional, Barchi, Katie, additional, Braun, Benjamin R., additional, Brilli, Richard J., additional, Campbell, Deborah R., additional, Chinnock, Richard E., additional, Corboy, Jacqueline B., additional, Depinet, Holly E., additional, Dykstra-Nykanen, Jill, additional, Genzel, Karen A., additional, Hakim, Hana, additional, Hron, Jonathan D., additional, Hueschen, Leslie A., additional, Huskins, W. Charles, additional, Kandil, Sarah B., additional, Kawai, Yu, additional, Laurich, V. Matt, additional, Loberger, Jeremy M., additional, Macias, Charles G., additional, Mackenzie, Joan E., additional, Mack, Elizabeth H., additional, Nagpal, Ashish S., additional, Niedner, Matthew, additional, Park, Daniel B., additional, Razzaqi, Faisal, additional, Redfern, Wendi S., additional, Rosen, Johanna R., additional, Rozenfeld, Ranna A., additional, Selby, Sam, additional, Sharron, Matthew P., additional, Silverman, Jonathan A., additional, Spack, Lawrence D., additional, Stalets, Erika L., additional, Thukaram, Roopa, additional, Wathen, Beth A., additional, Wilkes, Jennifer J., additional, Workman, Jennifer K., additional, and Zuccaro, Jennifer C., additional

Published
2022
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14. Intravenous Fluid Bolus Rates Associated with Outcomes in Pediatric Sepsis: A Multi-Center Analysis

Author

Mullan,Paul C, Pruitt,Christopher M, Levasseur,Kelly A, Macias,Charles G, Paul,Raina, Depinet,Holly, Nguyen,Anh Thy H, Melendez,Elliot, Mullan,Paul C, Pruitt,Christopher M, Levasseur,Kelly A, Macias,Charles G, Paul,Raina, Depinet,Holly, Nguyen,Anh Thy H, and Melendez,Elliot

Abstract

Paul C Mullan,1 Christopher M Pruitt,2 Kelly A Levasseur,3 Charles G Macias,4 Raina Paul,5 Holly Depinet,6 Anh Thy H Nguyen,7 Elliot Melendez8 1Department of Pediatrics, Division of Emergency Medicine, Eastern Virginia Medical School, Children’s Hospital of the King’s Daughters, Norfolk, VA, USA; 2Department of Pediatrics, Division of Pediatric Emergency Medicine, Medical University of South Carolina, Charleston, SC, USA; 3Pediatric Emergency Medicine, Beaumont Children’s Hospital, Royal Oak, MI, USA; 4Division of Pediatric Emergency Medicine, University Hospitals Rainbow Babies and Children’s, Case Western Reserve University School of Medicine, Cleveland, OH, USA; 5Department of Emergency Medicine, Advocate Children’s Hospital, Park Ridge, IL, USA; 6Division of Emergency Medicine, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, USA; 7Johns Hopkins All Children’s Institute for Clinical and Translational Research, St. Petersburg, FL, USA; 8Division of Pediatric Critical Care, Connecticut Children’s Medical Center, University of Connecticut, Hartford, CT, USACorrespondence: Paul C Mullan, Email mullan20@gmail.comPurpose: Pediatric sepsis guidelines recommend rapid intravenous fluid (IVF) bolus administration rates (BAR). Recent sepsis studies suggest that rapid BAR may be associated with increased morbidity. We aimed to describe the association between emergency department (ED) IVF BAR and clinical outcomes in pediatric sepsis.Patients and Methods: Secondary post-hoc analysis of retrospective cohort data from 19 hospitals in the Pediatric Septic Shock Collaborative (PSSC) database. Patients with presumed septic shock were defined by severe sepsis/septic shock diagnostic codes, receipt of septic shock therapies, or floor-to-ICU transfers within 12 hours from ED admission for septic shock. Patients (2 months– 21 years) with complete data on weight, antibiotic receipt

Published
2022

16. Sudden cardiac death under anesthesia in pediatric patient with williams syndrome: A case report and review of literature

Author

Gupta Punkaj, Tobias Joseph, Goyal Sunali, Miller Martin, Melendez Elliot, Noviski Natan, De Moor Michael, and Mehta Vipin

Subjects
Anaphylactic reaction, cardiac catheterization, dysmorphism, Williams syndrome, resuscitation, Anesthesiology, RD78.3-87.3, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Williams syndrome is a complex syndrome characterized by developmental abnormalities, craniofacial dysmorphic features, and cardiac anomalies. Sudden death has been described as a very common complication associated with anesthesia, surgery, and procedures in this population. Anatomical abnormalities associated with the heart pre-dispose these individuals to sudden death. In addition to a sudden and rapid downhill course, lack of response to resuscitation is another significant feature seen in these patients. The authors report a five-year-old male with Williams syndrome, hypothyroidism, and attention deficit hyperactivity disorder. He suffered an anaphylactic reaction during CT imaging with contrast. Resuscitation was unsuccessful. Previous reports regarding the anesthetic management of patients with Williams are reviewed and the potential for sudden death or peri-procedure related cardiac arrest discussed in this report. The authors also review reasons for refractoriness to defined resuscitation guidelines in this patient population.

Published
2010

22. A Quality Improvement Collaborative Improves Care for Pediatric Septic Shock*

Author

Toni Wakefield, Gitte Y. Larsen, Beth Wathen, Raina Paul, Derek S. Wheeler, Melendez Elliot, Charles G. Macias, and Laura Chapman

Subjects
Sepsis, medicine.medical_specialty, Quality management, business.industry, Septic shock, Pediatrics, Perinatology and Child Health, medicine, Consensus conference, medicine.disease, business, Intensive care medicine, Severe sepsis
Abstract

BACKGROUND: Sepsis is a leading cause of morbidity in children worldwide. Barriers exist for timely recognition and management. We sought to improve timely management for patients with sepsis and improve mortality through a one-year quality improvement (QI) collaborative. METHODS: 15 hospitals initially enrolled through this Children’s Hospital Association (CHA) collaborative from June 2012-2013. Children from the ED, ICU and floor with sepsis, severe sepsis and septic shock were included. Definitions of sepsis were institutionally based but were encouraged to model the International Sepsis Consensus Conference guidelines by Goldstein et al. Time of sepsis onset …

Published
2018

24. Croup

Author

Baiu, Ioana, primary and Melendez, Elliot, additional

Published
2019
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35. Vascular Endothelial Growth Factor and Soluble Vascular Endothelial Growth Factor Receptor as Novel Biomarkers for Poor Outcomes in Children With Severe Sepsis and Septic Shock

Author

Whitney, Jane E., Silverman, Melanie, Norton, Jackson S., Bachur, Richard G., and Melendez, Elliot

Abstract

Vascular endothelial growth factor (VEGF) and its receptor, soluble fms-like tyrosine kinase (sFLT), are biomarkers of endothelial activation. Vascular endothelial growth factor and sFLT have been associated with sepsis severity among adults, but pediatric data are lacking. The goal of this study was to assess VEGF and sFLT as predictors of outcome for children with sepsis.

Published
2024
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37. 746

Author

Wong, Jackson, primary, Kanevsky, Estella, additional, Agus, Michael, additional, Graham, Dionne, additional, Bartlett, Joshua, additional, and Melendez, Elliot, additional

Published
2014
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39. 390

Author

Wong, Jackson, primary, Agus, Michael, additional, Sang, Jessica, additional, Whalen, Melissa, additional, Bartlett, Joshua, additional, Graham, Dionne, additional, Dwyer, Danielle, additional, and Melendez, Elliot, additional

Published
2013
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40. 865: ESCAPING THE TRADITIONAL: USING AN ESCAPE ROOM AS AN INNOVATIVE TOOL TO TEACH CRM PRINCIPLES.

Author

Parker, Robert and Melendez, Elliot

Subjects
*ESCAPE rooms, *PEDIATRIC nursing
Abstract

A sepsis scenario guided participants through active resuscitation of a sick child using hidden clues/puzzles that unlocked treatments enabling progression through the scenario. Participants were assessed on enjoyment of the task, frequency of use of CRM principles, and adherence to a protocolized based sepsis resuscitation algorithm. [Extracted from the article]

Published
2023
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42. Case 3-2012

Author

Melendez, Elliot, primary, Goldstein, Allan M., additional, Sagar, Pallavi, additional, and Badizadegan, Kamran, additional

Published
2012
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50. Case 3-2012.

Author

Cabot, Richard C., Harris, Nancy Lee, Shepard, Jo-Anne O., Rosenberg, Eric S., Cort, Alice M., Ebeling, Sally H., Peters, Christine C., Melendez, Elliot, Goldstein, Allan M., Sagar, Pallavi, and Badizadegan, Kamran

Subjects
*DIARRHEA, *MEDICAL personnel, *INFANTS, *BACTEREMIA
Abstract

The article describes the case of a six-day-old male patient who was admitted to a medical facility due to diarrhea, vomiting as well as abdominal distention. Medical professionals obtained samples of blood, urine and cerebrospinal fluid from the patient to rule out potential development of bacteremia, urinary-tract infection and meningitis. The case focuses on the need for medical experts to first consider life-threatening conditions in newborn patients.

Published
2012
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