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3. Alterations in gastrointestinal motility assessed by high-resolution antroduodenal manometry in patients with severe disorders of gut-brain interaction.

Author

Soliman, Heithem, Wuestenberghs, Fabien, Desprez, Charlotte, Leroi, Anne-Marie, Melchior, Chloe, and Gourcerol, Guillaume

Subjects
ESOPHAGEAL motility disorders, GASTROINTESTINAL motility, GASTROINTESTINAL motility disorders, IRRITABLE colon
Abstract

Data are limited regarding gastrointestinal motility disturbance in disorders of gut-brain interaction (DGBI). This study aimed to characterize antroduodenal motor alterations in patients with high-resolution antroduodenal manometry (HR-ADM). HR-ADM was performed in patients with severe DGBI and compared with healthy volunteers (HV). HR-ADM used a commercially available probe composed of 36 electronic sensors spaced 1 cm apart and positioned across the pylorus. Antral and duodenal motor high-resolution profiles were analyzed, based on the frequency, amplitude, and contractile integral/sensor (CI/s) calculated for each phase of the migrating motor complex (MMC). Eighteen HV and 64 patients were investigated, 10 with irritable bowel syndrome (IBS), 24 with functional dyspepsia (FD), 15 with overlap IBS-FD, and 15 with other DGBI. Compared with HV, patients had a lower frequency of phase II duodenal contractions (27 vs. 51 per hour; P ¼ 0.002) and a lower duodenal phase II contraction amplitude (70 vs. 100 mmHg; P ¼ 0.01), resulting in a lower CI/s of phase II (833 vs. 1,901 mmHg·cm·s; P < 0.001) in the duodenum. In addition, the frequency of phase II propagated antroduodenal contractions was lower (5 vs. 11 per hour; P < 0.001) in patients compared with HV. Interestingly, the antral CI/s of phase III was decreased in FD patients but not in IBS patients. Patients with severe DGBI display alterations in antral and intestinal motility assessed by commercially available HR-ADM. Whether these alterations may explain symptom profiles in such patients remains to be confirmed (NCT04918329 and NCT01519180). NEW & NOTEWORTHY Gastrointestinal dysmotility has been assessed poorly in disorders of gut-brain interaction (DGBI), especially with high-resolution antroduodenal manometry. Plots of DGBI patients showed lower duodenal contractions during phase II regarding amplitude, frequency, and contractile integral/sensor (CI/s) compared with healthy volunteers. A lower frequency of propagated antroduodenal contractions was also reported. Finally, antral CI/s was lower in patients with functional dyspepsia during phase III. Further studies are needed to assess the clinical significance of these alterations. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected role in gut homeostasis

Author

Schmitt, Charlotte C., Aranias, Thomas, Viel, Thomas, Chateau, Danielle, Le Gall, Maude, Waligora-Dupriet, Anne-Judith, Melchior, Chloé, Rouxel, Ophélie, Kapel, Nathalie, Gourcerol, Guillaume, Tavitian, Bertrand, Lehuen, Agnès, Brot-Laroche, Edith, Leturque, Armelle, Serradas, Patricia, and Grosfeld, Alexandra

Published
2017
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7. Identification of bacterial lipopeptides as key players in IBS

Author

Petitfils, Camille, primary, Maurel, Sarah, additional, Payros, Gaelle, additional, Hueber, Amandine, additional, Agaiz, Bahija, additional, Gazzo, Géraldine, additional, Marrocco, Rémi, additional, Auvray, Frédéric, additional, Langevin, Geoffrey, additional, Motta, Jean-Paul, additional, Floch, Pauline, additional, Tremblay-Franco, Marie, additional, Galano, Jean-Marie, additional, Guy, Alexandre, additional, Durand, Thierry, additional, Lachambre, Simon, additional, Durbec, Anaëlle, additional, Hussein, Hind, additional, Decraecker, Lisse, additional, Bertrand-Michel, Justine, additional, Saoudi, Abdelhadi, additional, Oswald, Eric, additional, Poisbeau, Pierrick, additional, Dietrich, Gilles, additional, Melchior, Chloe, additional, Boeckxstaens, Guy, additional, Serino, Matteo, additional, Le Faouder, Pauline, additional, and Cenac, Nicolas, additional

Published
2022
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8. Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Can Be the Best Therapeutic Option in Severely Immunocompromised Patients Depending on a Case-by-Case Assessment of the Benefit-to-Risk Ratio

Author

Benech, Nicolas, Cassir, Nadim, Alric, Laurent, Melchior, Chloé, Mosca, Alexis, Joly, Anne-Christine, Kapel, Nathalie, Barbut, Frédéric, Galperine, Tatiana, Pigneur, Bénédicte, Davido, Benjamin, Schneider, Stéphane, Briot, Thomas, Wasiak, Mathieu, Nebad, Biba, Batista, Rui, Bleibtreu, Alexandre, Scanzi, Julien, Sokol, Harry, Sintes, Rachel, Corriger, Alexandrine, Flet, Laurent, Perlemuter, Gabriel, Ahloulay, Mina, Yaye, Hassane Sadou, De Rougemont, Alexis, Olivier, Emmanuelle, Burucoa, Christophe, Gobert, Jean-gérard, Landman, Cecilia, Vignal, Luc, Joly, Francisca, Ravinet, Aurélie, Bellanger, Agnès, Sabate, Jean-Marc, Humbert, Caroline, Wisnewsky, Judith Aron, Charpentier, Chloé, Moreno-Sabater, Alicia, Takoudju, Céline, Poirier, Philippe, Tanne, Florence, De Lastours, Victoire, and Stampfli, Camille

Published
2024
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11. Is it necessary to perform a morphological assessment for an esophageal motility disorder? A retrospective descriptive study

Author

Latrache, Sofya, primary, Melchior, Chloe, additional, Desprez, Charlotte, additional, Sidali, Sabrina, additional, Recton, Julien, additional, Touchais, Olivier, additional, van der Eecken, Elise, additional, Wuestenberghs, Fabien, additional, Charpentier, Cloe, additional, Leroi, Anne Marie, additional, and Gourcerol, Guillaume, additional

Published
2021
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12. Is it necessary to perform a morphological assessment for an esophageal motility disorder? A retrospective descriptive study.

Author

UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (MGD) Service de gastro-entérologie, Latrache, Sofya, Melchior, Chloe, Desprez, Charlotte, Sidali, Sabrina, Recton, Julien, Touchais, Olivier, van der Eecken, Elise, Wuestenberghs, Fabien, Charpentier, Cloe, Leroi, Anne Marie, Gourcerol, Guillaume, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (MGD) Service de gastro-entérologie, Latrache, Sofya, Melchior, Chloe, Desprez, Charlotte, Sidali, Sabrina, Recton, Julien, Touchais, Olivier, van der Eecken, Elise, Wuestenberghs, Fabien, Charpentier, Cloe, Leroi, Anne Marie, and Gourcerol, Guillaume

Abstract

Esophageal motility disorders are most often of primary origin but may be secondary to an occult malignancy or another etiology. High-resolution esophageal manometry cannot differentiate between secondary or primary origin. This study aimed at discussing the usefulness of a morphological assessment in the diagnosis of specific esophageal motility disorders, and to establish the predictive factors of a potential secondary origin. In this retrospective study, patients with suspected esophageal motility disorders who underwent an esophageal manometry were included. High-resolution manometry results were interpreted according to the Chicago Classification, 3rd version. The results of endoscopic ultrasound and computed tomography, assessed by a panel of experts, allowed to diagnose a secondary origin. Out of 2138 patients undergoing manometry, 502 patients had a esophageal motility disorder suspect to be from secondary origin; among them 182 patients underwent tomography or endoscopic ultrasound. According to experts, 16 patients (8.8%) had a secondary esophageal motility disorder: esophagogastric junction outflow obstruction (n = 7), jackhammer disorder (n = 4), achalasia (n = 3) and localized pressurization (n = 2). The etiology was malignant in 8 patients. Predictive factors suggesting potential secondary esophageal motility disorders were smoking, age ≥ 58 years and an Integrated Relaxation Pressure higher than 10 mmHg for water swallows. Esophageal motility disorders with organic origin are not uncommon. A morphological assessment using endoscopic ultrasonography and/or computed tomography may be of use to diagnose a secondary origin, especially in the elderly and smokers.

Published
2021

13. Identification of bacterial lipopeptides as key players in IBS

Author

Petitfils, Camille, Maurel, Sarah, Payros, Gaelle, Hueber, Amandine, Agaiz, Bahija, Gazzo, Géraldine, Marrocco, Rémi, Auvray, Frédéric, Langevin, Geoffrey, Motta, Jean-Paul, Floch, Pauline, Tremblay-Franco, Marie, Galano, Jean-Marie, Guy, Alexandre, Durand, Thierry, Lachambre, Simon, Durbec, Anae¨lle, Hussein, Hind, Decraecker, Lisse, Bertrand-Michel, Justine, Saoudi, Abdelhadi, Oswald, Eric, Poisbeau, Pierrick, Dietrich, Gilles, Melchior, Chloe, Boeckxstaens, Guy, Serino, Matteo, Le Faouder, Pauline, and Cenac, Nicolas

Abstract

ObjectivesClinical studies revealed that early-life adverse events contribute to the development of IBS in adulthood. The aim of our study was to investigate the relationship between prenatal stress (PS), gut microbiota and visceral hypersensitivity with a focus on bacterial lipopeptides containing γ-aminobutyric acid (GABA).DesignWe developed a model of PS in mice and evaluated, in adult offspring, visceral hypersensitivity to colorectal distension (CRD), colon inflammation, barrier function and gut microbiota taxonomy. We quantified the production of lipopeptides containing GABA by mass spectrometry in a specific strain of bacteria decreased in PS, in PS mouse colons, and in faeces of patients with IBS and healthy volunteers (HVs). Finally, we assessed their effect on PS-induced visceral hypersensitivity.ResultsPrenatally stressed mice of both sexes presented visceral hypersensitivity, no overt colon inflammation or barrier dysfunction but a gut microbiota dysbiosis. The dysbiosis was distinguished by a decreased abundance of Ligilactobacillus murinus, in both sexes, inversely correlated with visceral hypersensitivity to CRD in mice. An isolate from this bacterial species produced several lipopeptides containing GABA including C14AsnGABA. Interestingly, intracolonic treatment with C14AsnGABA decreased the visceral sensitivity of PS mice to CRD. The concentration of C16LeuGABA, a lipopeptide which inhibited sensory neurons activation, was decreased in faeces of patients with IBS compared with HVs.ConclusionPS impacts the gut microbiota composition and metabolic function in adulthood. The reduced capacity of the gut microbiota to produce GABA lipopeptides could be one of the mechanisms linking PS and visceral hypersensitivity in adulthood.

Published
2023
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14. Mo1106 PREVALENCE OF MEAL-RELATED GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH A DISORDER OF GUT-BRAIN INTERACTION

Author

Colomier, Esther, Holvoet, Lieselot, Carbone, Florencia, Bai, Tao, Liu, Jinsong, Chuah, Kee-Huat, Mahadeva, Sanjiv, Siah, Kewin T., Melchior, Chloé, Gourcerol, Guillaume, Liptak, Peter, Banovcin, Peter, Holtmann, Gerald, Carabotti, Marilia, Suzuki, Hidekazu, Sano, Masaya, Ueda, Takashi, Hajihashemi, Parisa, Shahoon, Hassan, Simren, Magnus, Gwee, Kok-Ann, and Tack, Jan F.

Published
2023
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19. Jackhammer Esophagus: Clinical, Functional and Therapeutic Data. a Retrospective Multicenter Study in 272 Patients

Author

Philonenko, Sara, primary, Gourcerol, Guillaume, additional, Zerbib, Frank, additional, Ropert, Alain, additional, Varannes, Stanislas Bruley des, additional, Barret, Maximilien, additional, Vitton, Veronique, additional, Bouchoucha, Michel, additional, Melchior, Chloe, additional, Badat, Yaeesh, additional, Mion, Francois, additional, Brochard, Charlene, additional, Touchefeu, Yann, additional, Chryssostalis, Ariane, additional, Gorbatchef, Caroline, additional, Benezech, Alban, additional, Benamouzig, Robert, additional, Roman, Sabine, additional, and Coffin, Benoit, additional

Published
2017
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20. Sa1660 - Jackhammer Esophagus: Clinical, Functional and Therapeutic Data. a Retrospective Multicenter Study in 272 Patients

Author

Philonenko, Sara, Gourcerol, Guillaume, Zerbib, Frank, Ropert, Alain, Varannes, Stanislas Bruley des, Barret, Maximilien, Vitton, Veronique, Bouchoucha, Michel, Melchior, Chloe, Badat, Yaeesh, Mion, Francois, Brochard, Charlene, Touchefeu, Yann, Chryssostalis, Ariane, Gorbatchef, Caroline, Benezech, Alban, Benamouzig, Robert, Roman, Sabine, and Coffin, Benoit

Published
2017
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