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1. Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation

Author

CTI Otten, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Unit SKIM, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G, Wisse, Bram W, Reteig, Leon, Gruijters, Maartje L, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, Otten, Henny G, CTI Otten, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Unit SKIM, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G, Wisse, Bram W, Reteig, Leon, Gruijters, Maartje L, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, and Otten, Henny G

Published
2024

2. Determination of the clinical relevance of donor epitope‐specific HLA‐antibodies in kidney transplantation

Author

Kardol‐Hoefnagel, Tineke, primary, Senejohnny, Danial Mohammadi, additional, Kamburova, Elena G., additional, Wisse, Bram W., additional, Reteig, Leon, additional, Gruijters, Maartje L., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Spierings, Eric, additional, Hack, Cornelis E., additional, van Reekum, Franka E., additional, van Zuilen, Arjan D., additional, Verhaar, Marianne C., additional, Bots, Michiel L., additional, Drop, Adriaan C. A. D., additional, Plaisier, Loes, additional, Melchers, Rowena C. A., additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J. A., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Voorter, Christina E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A. C. J., additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Shaikh A., additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A. M. I., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Hoitsma, Andries, additional, van der Boog, Paul J. M., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Roelen, Dave L., additional, Claas, Frans H., additional, Bemelman, Frederike J., additional, Senev, Aleksandar, additional, Naesens, Maarten, additional, Heidt, Sebastiaan, additional, and Otten, Henny G., additional

Published
2024
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3. Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival.

Author

Kardol‐Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C. A. D., Plaisier, Loes, Melchers, Rowena C. A., Seelen, Marc A. J., and Sanders, Jan Stephan

Subjects
IMMUNOGLOBULINS, GRAFT survival, KIDNEYS, KIDNEY transplantation
Abstract

In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Antibodies against ARHGDIB are associated with long-term kidney graft loss

Author

Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Otten, Henny G, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, and Otten, Henny G

Published
2019

5. Antibodies against ARHGDIB are associated with long-term kidney graft loss

Author

CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, CDL unit Immunoserologie, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Otten, Henny G, CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, CDL unit Immunoserologie, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, and Otten, Henny G

Published
2019

6. Antibodies against ARHGDIBare associated with long‐term kidney graft loss

Author

Kamburova, Elena G., Gruijters, Maartje L., Kardol‐Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Reekum, Franka E., Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C. A. D., Plaisier, Loes, Melchers, Rowena C. A., Seelen, Marc A. J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J. A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G. J., Voorter, Christina E., Wieten, Lotte, Duijnhoven, Elly M., Gelens, Mariëlle A. C. J., Christiaans, Maarten H. L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Pant, Karlijn A. M. I., Weerd, Neelke C., Berge, Ineke J. M., Hoitsma, Andries, Boog, Paul J. M., de Fijter, Johan W., Betjes, Michiel G. H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., and Otten, Henny G.

Abstract

The clinical significance of non‐HLAantibodies on renal allograft survival is a matter of debate, due to differences in reported results and lack of large‐scale studies incorporating analysis of multiple non‐HLAantibodies simultaneously. We developed a multiplex non‐HLAantibody assay against 14 proteins highly expressed in the kidney. In this study, the presence of pretransplant non‐HLAantibodies was correlated to renal allograft survival in a nationwide cohort of 4770 recipients transplanted between 1995 and 2006. Autoantibodies against Rho GDP‐dissociation inhibitor 2 (ARHGDIB) were significantly associated with graft loss in recipients transplanted with a deceased‐donor kidney (N = 3276) but not in recipients of a living‐donor kidney (N = 1496). At 10 years after deceased‐donor transplantation, recipients with anti‐ARHGDIBantibodies (94/3276 = 2.9%) had a 13% lower death‐censored covariate‐adjusted graft survival compared to the anti‐ARHGDIB‐negative (3182/3276 = 97.1%) population (hazard ratio 1.82; 95% confidence interval, 1.32‐2.53; P= .0003). These antibodies occur independently from donor‐specific anti‐HLA antibodies (DSA) or other non‐HLAantibodies investigated. No significant relations with graft loss were found for the other 13 non‐HLAantibodies. We suggest that pretransplant risk assessment can be improved by measuring anti‐ARHGDIBantibodies in all patients awaiting deceased‐donor transplantation. From a multicenter evaluation of kidney transplants, the authors report that the pretransplant presence of autoantibodies against ARHGDIB are associated with long‐term graft loss in recipients transplanted with a deceased donor kidney, independent from donor‐specific HLA antibodies.

Published
2019
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7. Antibodies against ARHGDIB are associated with long-term kidney graft loss.

Author

Kamburova EG, Gruijters ML, Kardol-Hoefnagel T, Wisse BW, Joosten I, Allebes WA, van der Meer A, Hilbrands LB, Baas MC, Spierings E, Hack CE, van Reekum FE, van Zuilen AD, Verhaar MC, Bots ML, Drop ACAD, Plaisier L, Melchers RCA, Seelen MAJ, Sanders JS, Hepkema BG, Lambeck AJA, Bungener LB, Roozendaal C, Tilanus MGJ, Voorter CE, Wieten L, van Duijnhoven EM, Gelens MACJ, Christiaans MHL, van Ittersum FJ, Nurmohamed SA, Lardy NM, Swelsen W, van der Pant KAMI, van der Weerd NC, Ten Berge IJM, Hoitsma A, van der Boog PJM, de Fijter JW, Betjes MGH, Heidt S, Roelen DL, Claas FH, Bemelman FJ, and Otten HG

Subjects
Adult, Female, Follow-Up Studies, Graft Rejection diagnosis, Graft Rejection etiology, Humans, Isoantibodies immunology, Kidney Failure, Chronic immunology, Kidney Failure, Chronic mortality, Kidney Failure, Chronic surgery, Living Donors statistics & numerical data, Male, Middle Aged, Postoperative Complications diagnosis, Postoperative Complications etiology, Prognosis, Retrospective Studies, Risk Factors, Autoantibodies immunology, Graft Rejection mortality, Graft Survival immunology, HLA Antigens immunology, Kidney Transplantation adverse effects, Postoperative Complications mortality, rho Guanine Nucleotide Dissociation Inhibitor beta immunology
Abstract

The clinical significance of non-HLA antibodies on renal allograft survival is a matter of debate, due to differences in reported results and lack of large-scale studies incorporating analysis of multiple non-HLA antibodies simultaneously. We developed a multiplex non-HLA antibody assay against 14 proteins highly expressed in the kidney. In this study, the presence of pretransplant non-HLA antibodies was correlated to renal allograft survival in a nationwide cohort of 4770 recipients transplanted between 1995 and 2006. Autoantibodies against Rho GDP-dissociation inhibitor 2 (ARHGDIB) were significantly associated with graft loss in recipients transplanted with a deceased-donor kidney (N = 3276) but not in recipients of a living-donor kidney (N = 1496). At 10 years after deceased-donor transplantation, recipients with anti-ARHGDIB antibodies (94/3276 = 2.9%) had a 13% lower death-censored covariate-adjusted graft survival compared to the anti-ARHGDIB-negative (3182/3276 = 97.1%) population (hazard ratio 1.82; 95% confidence interval, 1.32-2.53; P = .0003). These antibodies occur independently from donor-specific anti-HLA antibodies (DSA) or other non-HLA antibodies investigated. No significant relations with graft loss were found for the other 13 non-HLA antibodies. We suggest that pretransplant risk assessment can be improved by measuring anti-ARHGDIB antibodies in all patients awaiting deceased-donor transplantation., (© 2019 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.)

Published
2019
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