Search

Your search keyword '"Melanie Page"' showing total 48 results
Start Over Author "Melanie Page"
48 results on '"Melanie Page"'

1. Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

Author

Christos Tziotzios, Christos Petridis, Nick Dand, Chrysanthi Ainali, Jake R. Saklatvala, Venu Pullabhatla, Alexandros Onoufriadis, Rashida Pramanik, David Baudry, Sang Hyuck Lee, Kristie Wood, Lu Liu, Seth Seegobin, Gregory A. Michelotti, Su M. Lwin, Evangelos A. A. Christou, Charles J. Curtis, Emanuele de Rinaldis, Alka Saxena, Susan Holmes, Matthew Harries, Ioulios Palamaras, Fiona Cunningham, Gregory Parkins, Manjit Kaur, Paul Farrant, Andrew McDonagh, Andrew Messenger, Jennifer Jones, Victoria Jolliffe, Iaisha Ali, Michael Ardern-Jones, Charles Mitchell, Nigel Burrows, Ravinder Atkar, Cedric Banfield, Anton Alexandroff, Caroline Champagne, Hywel L. Cooper, Sergio Vañó-Galván, Ana Maria Molina-Ruiz, Nerea Ormaechea Perez, Girish K. Patel, Abby Macbeth, Melanie Page, Alyson Bryden, Megan Mowbray, Shyamal Wahie, Keith Armstrong, Nicola Cooke, Mark Goodfield, Irene Man, David de Berker, Giles Dunnill, Anita Takwale, Archana Rao, Tee-Wei Siah, Rodney Sinclair, Martin S. Wade, Ncoza C. Dlova, Jane Setterfield, Fiona Lewis, Kapil Bhargava, Niall Kirkpatrick, Xavier Estivill, Catherine M. Stefanato, Carsten Flohr, Timothy Spector, Fiona M. Watt, Catherine H. Smith, Jonathan N. Barker, David A. Fenton, Michael A. Simpson, and John A. McGrath

Subjects
Science
Abstract

Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation which highlights HLA-B*07:02 as a risk factor.

Published
2019
Full Text
View/download PDF

4. Chapitre 12. Le temps de repenser les travaux de laboratoire !

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

5. Chapitre 2. Le conseiller pédagogique au collégial : s'adapter en contexte de mouvance

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

6. Chapitre 5. Des cours d'éducation physique efficaces devant l'écran ? Absolument !

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

7. Chapitre 13. Les évaluations en ligne face à une conception universelle de l'apprentissage : du diagnostic au sommatif

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

8. Chapitre 8. S'évader grâce aux plateformes numériques

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

9. Quatrième de couverture

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

10. Chapitre 16. L'approche métacognitive : une solution universelle ayant pour but d'assurer la crédibilité des évaluations en ligne au Cégep à distance

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

11. Partie B. Soutenir l'apprentissage et l'engagement en formation à distance

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

12. Chapitre 10. Un scénario pédagogique ludique sous la forme d'une aventure « dont vous êtes le héros » afin de soutenir l'apprentissage en ligne en Technologie d'analyses biomédical

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

13. Partie C. Adapter son approche pédagogique en formation à distance en réponse aux besoins particuliers

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

14. Notices biographiques

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

15. Chapitre 15. Le jumelage interculturel et intergénérationnel dans l'apprentissage du français langue seconde

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

16. Dans la même collection

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

17. Couverture de livre

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

18. Conclusion générale

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

19. Chapitre 14. L'innovation et la continuité dans la relation pédagogique, en contexte de pandémie - L'exemple de Réussite 911

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

20. Chapitre 4. Innover avec l'ECRAN - Espace collaboratif de ressources pour l'apprentissage numérique

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

21. Table des matières

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

22. Partie A. Innover pour mieux accompagner dans le contexte numérique

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

23. Chapitre 7. La formation à distance en design d'intérieur

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

24. Chapitre 9. La mise en application de l'apprentissage actif en contexte de distanciation physique : des liens virtuels mais significatifs

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

25. Chapitre 6. Maintenir l'engagement et la persévérance des étudiants en formation à distance

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

26. Chapitre 11. Les réseaux sociaux, une stratégie pour rejoindre (ou motiver) les étudiants

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

27. Introduction

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

28. Liste des figures et tableaux

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

29. Liste des sigles et acronymes

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

30. Chapitre 3. La formation d'une brigade technopédagogique PAR et POUR les enseignants

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

31. Remerciements

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

32. Page de la série, demi-titre, titre, crédits

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

33. Chapitre 1. La relation tuteur-étudiant au cœur du dispositif pédagogique en formation à distance

Author

Élise Achille-Sautrelle, Catherine Audet, Sabrina Boisvert, Josée Boutin, Martin Carignan, Renée Charbonneau, Sharon Coyle, Caroline Crépeau, Lorraine Denis, Chloé Dufour, Laurence Dumont, Anne-Marie Dussault, Julie Gagné, Philippe Gagné, Marie-Andrée Godbout, Mylène Goulet, Marie-Claude Hallé-Bolduc, Nancy Jolicoeur, Nelly Kallini, France Lafleur, Charles Lambert, Marc Landry, Gabrielle Lapierre, Stéphanie Lapointe, Charles Laporte, Philippe Lavigueur, Kathleen Lebeuf, Marilène Lemay, Émilie Lemire-Lafontaine, Émilie Marchand, Jules Massé, Jessica Métivier, Radhi Mhiri, Anne-Marie Nault, Vahé Nerguizian, Mélanie Pagé, Stéphanie Pitre, Argantel Radier, Martin Roy, Maarouf Saad, Ghislain Samson, Céline Tengelsen, and Geneviève Thibault

Published
2022

34. A rash that appeared on holiday

Author

Melanie Page and A. E. Macbeth

Subjects
body regions, Blistering rash, medicine.medical_specialty, integumentary system, business.industry, Hospital admission, medicine, General Medicine, medicine.symptom, business, Rash, Dermatology
Abstract

A 64 year old man developed a severe, erythematous, blistering rash that required hospital admission. His face, neck, forearms, and lower legs were affected (fig 1). The eruption …

Published
2017
Full Text
View/download PDF

35. CSF xanthochromia analysis takes longer following centralisation of the laboratories testing samples – how can we improve the time to result?

Author

Calum McGregor, Ian M Godber, Melanie Page, and Sean Martin

Subjects
Working hours, medicine.medical_specialty, medicine.diagnostic_test, BMJ Quality Improvement Programme, business.industry, Lumbar puncture, Time to result, Microsoft excel, General Medicine, medicine.disease, Surgery, Xanthochromia, Emergency medicine, medicine, Csf analysis, Subarachnoid haemorrhage, sense organs, business, Statistical software
Abstract

Lumbar puncture is an essential tool for excluding subarachnoid haemorrhage. In August 2012, the laboratory at which cerebrospinal fluid (CSF) is analysed for xanthochromia in Lanarkshire was centralised at Hairmyres (East Kilbride, UK). Prior to this, each of the three hospitals analysed their own specimens. We aim to assess whether or not the change in xanthochromia processing has resulted in diagnostic delay at Wishaw General Hospital in the assessment of CT negative possible subarachnoid haemorrhage. We subsequently assessed the impact of a strategy to minimise any delay, i.e. increasing laboratory processing hours. Patients undergoing CSF analysis for xanthochromia were identified directly from the laboratory database. Time of lumbar puncture, and time of xanthochromia results were obtained from the hospital9s laboratory computer system. Data were analysed using a commercially available statistical software programme (Microsoft Excel). Audit was repeated after the change to a centralised laboratory, and again following the increased laboratory working hours. Mean time from lumbar puncture to availability of xanthochromia result was significantly longer following the laboratory change (20.8±3.5 hours post [n=35] vs. 12.5±3.0 pre, p=0.01 [n=17]). However, following a change in the laboratory9s practice, there was no improvement (19.8±3.4 hours post practice change [n=35]), and this remained significantly longer when compared to the original laboratory set-up (p=0.025). The change in laboratory processing CSF samples for xanthochromia in Lanarkshire resulted in a significant delay in analysing the samples. Attempts by the laboratory to extend processing hours did not make any significant improvement, but having expanded our knowledge of the issues, further measures are now planned to minimise delays in the future. Centralisation of laboratory services for CSF analysis, whilst cheaper, may impact negatively on clinical care.

Published
2013

36. Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions

Author

Arnault Tauziède-Espariat, Aurore Siegfried, Yvan Nicaise, Thomas Kergrohen, Philipp Sievers, Alexandre Vasiljevic, Alexandre Roux, Edouard Dezamis, Chiara Benevello, Marie-Christine Machet, Sophie Michalak, Chloe Puiseux, Francisco Llamas-Gutierrez, Pierre Leblond, Franck Bourdeaut, Jacques Grill, Christelle Dufour, Léa Guerrini-Rousseau, Samuel Abbou, Volodia Dangouloff-Ros, Nathalie Boddaert, Raphaël Saffroy, Lauren Hasty, Ellen Wahler, Mélanie Pagès, Felipe Andreiuolo, Emmanuèle Lechapt, Fabrice Chrétien, Thomas Blauwblomme, Kévin Beccaria, Johan Pallud, Stéphanie Puget, Emmanuelle Uro-Coste, Pascale Varlet, and the RENOCLIP-LOC, the BIOMECA (Biomarkers for Ependymomas in Children, Adolescents) consortium

Subjects
Ependymoma, ZFTA, RELA, DNA-methylation, Clusters, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract The cIMPACT-NOW Update 7 has replaced the WHO nosology of “ependymoma, RELA fusion positive” by “Supratentorial-ependymoma, C11orf95-fusion positive”. This modification reinforces the idea that supratentorial-ependymomas exhibiting fusion that implicates the C11orf95 (now called ZFTA) gene with or without the RELA gene, represent the same histomolecular entity. A hot off the press molecular study has identified distinct clusters of the DNA methylation class of ZFTA fusion-positive tumors. Interestingly, clusters 2 and 4 comprised tumors of different morphologies, with various ZFTA fusions without involvement of RELA. In this paper, we present a detailed series of thirteen cases of non-RELA ZFTA-fused supratentorial tumors with extensive clinical, radiological, histopathological, immunohistochemical, genetic and epigenetic (DNA methylation profiling) characterization. Contrary to the age of onset and MRI aspects similar to RELA fusion-positive EPN, we noted significant histopathological heterogeneity (pleomorphic xanthoastrocytoma-like, astroblastoma-like, ependymoma-like, and even sarcoma-like patterns) in this cohort. Immunophenotypically, these NFκB immunonegative tumors expressed GFAP variably, but EMA constantly and L1CAM frequently. Different gene partners were fused with ZFTA: NCOA1/2, MAML2 and for the first time MN1. These tumors had epigenetic homologies within the DNA methylation class of ependymomas-RELA and were classified as satellite clusters 2 and 4. Cluster 2 (n = 9) corresponded to tumors with classic ependymal histological features (n = 4) but also had astroblastic features (n = 5). Various types of ZFTA fusions were associated with cluster 2, but as in the original report, ZFTA:MAML2 fusion was frequent. Cluster 4 was enriched with sarcoma-like tumors. Moreover, we reported a novel anatomy of three ZFTA:NCOA1/2 fusions with only 1 ZFTA zinc finger domain in the putative fusion protein, whereas all previously reported non-RELA ZFTA fusions have 4 ZFTA zinc fingers. All three cases presented a sarcoma-like morphology. This genotype/phenotype association requires further studies for confirmation. Our series is the first to extensively characterize this new subset of supratentorial ZFTA-fused ependymomas and highlights the usefulness of ZFTA FISH analysis to confirm the existence of a rearrangement without RELA abnormality.

Published
2021
Full Text
View/download PDF

39. The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of 'CNS tumors with BCOR internal tandem duplication'

Author

Arnault Tauziède-Espariat, Gaëlle Pierron, Aurore Siegfried, Delphine Guillemot, Emmanuelle Uro-Coste, Yvan Nicaise, David Castel, Isabelle Catalaa, Delphine Larrieu-Ciron, Patrick Chaynes, Amaury de Barros, Julien Nicolau, Albane Gareton, Emmanuèle Lechapt, Fabrice Chrétien, Franck Bourdeaut, François Doz, Yassine Bouchoucha, Jacques Grill, Kévin Beccaria, Nathalie Boddaert, Raphaël Saffroy, Mélanie Pagès, and Pascale Varlet

Subjects
Neurology. Diseases of the nervous system, RC346-429
Published
2020
Full Text
View/download PDF

40. Molecular and clinicopathologic features of gliomas harboring NTRK fusions

Author

Matthew Torre, Varshini Vasudevaraja, Jonathan Serrano, Michael DeLorenzo, Seth Malinowski, Anne-Florence Blandin, Melanie Pages, Azra H. Ligon, Fei Dong, David M. Meredith, MacLean P. Nasrallah, Craig Horbinski, Sonika Dahiya, Keith L. Ligon, Mariarita Santi, Shakti H. Ramkissoon, Mariella G. Filbin, Matija Snuderl, and Sanda Alexandrescu

Subjects
NTRK, Glioma, NGS sequencing, Methylation, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes are detected in ≤2% of gliomas and can promote gliomagenesis. The remarkable therapeutic efficacy of TRK inhibitors, which are among the first Food and Drug Administration-approved targeted therapies for NTRK-fused gliomas, has generated significant clinical interest in characterizing these tumors. In this multi-institutional retrospective study of 42 gliomas with NTRK fusions, next generation DNA sequencing (n = 41), next generation RNA sequencing (n = 1), RNA-sequencing fusion panel (n = 16), methylation profile analysis (n = 18), and histologic evaluation (n = 42) were performed. All infantile NTRK-fused gliomas (n = 7) had high-grade histology and, with one exception, no other significant genetic alterations. Pediatric NTRK-fused gliomas (n = 13) typically involved NTRK2, ranged from low- to high-histologic grade, and demonstrated histologic overlap with desmoplastic infantile ganglioglioma, pilocytic astrocytoma, ganglioglioma, and glioblastoma, among other entities, but they rarely matched with high confidence to known methylation class families or with each other; alterations involving ATRX, PTEN, and CDKN2A/2B were present in a subset of cases. Adult NTRK-fused gliomas (n = 22) typically involved NTRK1 and had predominantly high-grade histology; genetic alterations involving IDH1, ATRX, TP53, PTEN, TERT promoter, RB1, CDKN2A/2B, NF1, and polysomy 7 were common. Unsupervised principal component analysis of methylation profiles demonstrated no obvious grouping by histologic grade, NTRK gene involved, or age group. KEGG pathway analysis detected methylation differences in genes involved in PI3K/AKT, MAPK, and other pathways. In summary, the study highlights the clinical, histologic, and molecular heterogeneity of NTRK-fused gliomas, particularly when stratified by age group.

Published
2020
Full Text
View/download PDF

41. Diffuse leptomeningeal glioneuronal tumor: a double misnomer? A report of two cases

Author

Romain Appay, Mélanie Pages, Carole Colin, David T. W. Jones, Pascale Varlet, and Dominique Figarella-Branger

Subjects
DLGNT, Adult, Supratentorial, BRAFV600E mutation, DNA-methylation profiling, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Diffuse leptomeningeal glioneuronal tumor (DLGNT) was introduced, for the first time, as a provisional entity in the 2016 WHO classification of central nervous system tumors. DLGNT mainly occur in children and characterized by a widespread leptomeningeal growth occasionally associated with intraspinal tumor nodules, an oligodendroglial-like cytology, glioneuronal differentiation and MAP-Kinase activation associated with either solitary 1p deletion or 1p/19q codeletion in the absence of IDH mutation. We report here two unexpected DLGNTs adult cases, characterized by a unique supratentorial circumscribed intraparenchymal tumor without leptomeningeal involvement in spite of long follow-up. In both cases, the diagnosis of DLGNT was made after DNA-methylation profiling which demonstrated that one case belonged to the DLGNT class whereas the other remained not classifiable but showed on CNV the characteristic genetic findings recorded in DLGNT. Both cases harbored 1p/19q codeletion associated with KIAA1549:BRAF fusion in one case and with BRAF V600E and PIK3CA E545A mutations, in the other. Our study enlarges the clinical and molecular spectrum of DLGNTs, and points out that the terminology of DLGNTs is not fully appropriate since some cases could have neither diffuse growth nor leptomeningeal dissemination. This suggests that DLGNTs encompass a wide spectrum of tumors that has yet to be fully clarified.

Published
2020
Full Text
View/download PDF

43. Pediatric methylation class HGNET-MN1: unresolved issues with terminology and grading

Author

Arnault Tauziède-Espariat, Mélanie Pagès, Alexandre Roux, Aurore Siegfried, Emmanuelle Uro-Coste, Yvan Nicaise, Annick Sevely, Marion Gambart, Sergio Boetto, Martin Dupuy, Pomone Richard, Romain Perbet, Matthieu Vinchon, Sabine Caron, Felipe Andreiuolo, Albane Gareton, Emmanuèle Lechapt, Fabrice Chrétien, Stéphanie Puget, Jacques Grill, Nathalie Boddaert, Pascale Varlet, and on behalf of the RENOCLIP-LOC

Subjects
MN1, HGNET, Astroblastoma, Meta-analysis, Neurology. Diseases of the nervous system, RC346-429
Published
2019
Full Text
View/download PDF

44. Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Author

Pratiti Bandopadhayay, Federica Piccioni, Ryan O’Rourke, Patricia Ho, Elizabeth M. Gonzalez, Graham Buchan, Kenin Qian, Gabrielle Gionet, Emily Girard, Margo Coxon, Matthew G. Rees, Lisa Brenan, Frank Dubois, Ofer Shapira, Noah F. Greenwald, Melanie Pages, Amanda Balboni Iniguez, Brenton R. Paolella, Alice Meng, Claire Sinai, Giovanni Roti, Neekesh V. Dharia, Amanda Creech, Benjamin Tanenbaum, Prasidda Khadka, Adam Tracy, Hong L. Tiv, Andrew L. Hong, Shannon Coy, Rumana Rashid, Jia-Ren Lin, Glenn S. Cowley, Fred C. Lam, Amy Goodale, Yenarae Lee, Kathleen Schoolcraft, Francisca Vazquez, William C. Hahn, Aviad Tsherniak, James E. Bradner, Michael B. Yaffe, Till Milde, Stefan M. Pfister, Jun Qi, Monica Schenone, Steven A. Carr, Keith L. Ligon, Mark W. Kieran, Sandro Santagata, James M. Olson, Prafulla C. Gokhale, Jacob D. Jaffe, David E. Root, Kimberly Stegmaier, Cory M. Johannessen, and Rameen Beroukhim

Subjects
Science
Abstract

BET-bromodomain inhibitors could be used to treat medulloblastoma tumors with Myc amplifications. Here, the authors show that both the response and resistance to BET inhibitors in mice is mediated by bHLH/homeobox transcription factors.

Published
2019
Full Text
View/download PDF

45. Levine's Guide to SPSS for Analysis of Variance

Author

Sanford L. Braver, David P. MacKinnon, Melanie Page, Sanford L. Braver, David P. MacKinnon, and Melanie Page

Subjects
SPSS (Computer file), Analysis of variance--Computer programs
Abstract

A greatly expanded and heavily revised second edition, this popular guide provides instructions and clear examples for running analyses of variance (ANOVA) and several other related statistical tests of significance with SPSS. No other guide offers the program statements required for the more advanced tests in analysis of variance. All of the programs in the book can be run using any version of SPSS, including versions 11 and 11.5. A table at the end of the preface indicates where each type of analysis (e.g., simple comparisons) can be found for each type of design (e.g., mixed two-factor design). Providing comprehensive coverage of the basic and advanced topics in ANOVA, this is the only book available that provides extensive coverage of SPSS syntax, including the commands and subcommands that tell SPSS what to do, as well as the pull-down menu point-and-click method (PAC). Detailed explanation of the syntax, including what is necessary, desired, and optional helps ensure that users can validate the analysis being performed. The book features the output of each design along with a complete explanation of the related printout. The new edition was reorganized to provide all analysis related to one design type in the same chapter. It now features expanded coverage of analysis of covariance (ANCOVA) and mixed designs, new chapters on designs with random factors, multivariate designs, syntax used in PAC, and all new examples of output with complete explanations. The new edition is accompanied by downloadable resources with all of the book's data sets, as well as exercises for each chapter. This book is ideal for readers familiar with the basic concepts of the ANOVA technique including both practicing researchers and data analysts, as well as advanced students learning analysis of variance.

Published
2003

46. SCOOP: Scicon's control of oil pollution

Author

Elizabeth Stamps and Melanie Page

Subjects
Pollution, media_common.quotation_subject, SCOOP, Control (management), Liability insurance, Tidal current, Section (archaeology), General Earth and Planetary Sciences, Environmental science, Submarine pipeline, Oil pollution, computer, Simulation, General Environmental Science, media_common, computer.programming_language, Marine engineering
Abstract

Thefeatures and uses of SCOOP are described in thefollowing paper. Section 2 provides a description of the theoretical model behind SCOOP whilst Section 3 describes the procedure to generate tidal current databanks, which are used in the SCOOP model. Thefourth section describes the actual running of the package including the data required and the output produced for each simulation. Section 5 explains the uses of the package and the applicationsfor pollution control officers, offshore operators and insurance liability assessors.

Published
1986
Full Text
View/download PDF

47. Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification.

Author

Felipe Andreiuolo, Gwénaël Le Teuff, Mohamed Amine Bayar, John-Paul Kilday, Torsten Pietsch, André O von Bueren, Hendrik Witt, Andrey Korshunov, Piergiorgio Modena, Stefan M Pfister, Mélanie Pagès, David Castel, Felice Giangaspero, Leila Chimelli, Pascale Varlet, Stefan Rutkowski, Didier Frappaz, Maura Massimino, Richard Grundy, Jacques Grill, and SIOP Ependymoma Biology Working Group BIOMECA (BIOlogical Markers for Ependymomas in Children and Adolescents)

Subjects
Medicine, Science
Abstract

Despite multimodal therapy, prognosis of pediatric intracranial ependymomas remains poor with a 5-year survival rate below 70% and frequent late deaths.This multicentric European study evaluated putative prognostic biomarkers. Tenascin-C (TNC) immunohistochemical expression and copy number status of 1q25 were retained for a pooled analysis of 5 independent cohorts. The prognostic value of TNC and 1q25 on the overall survival (OS) was assessed using a Cox model adjusted to age at diagnosis, tumor location, WHO grade, extent of resection, radiotherapy and stratified by cohort. Stratification on a predictor that did not satisfy the proportional hazards assumption was considered. Model performance was evaluated and an internal-external cross validation was performed.Among complete cases with 5-year median follow-up (n = 470; 131 deaths), TNC and 1q25 gain were significantly associated with age at diagnosis and posterior fossa tumor location. 1q25 status added independent prognostic value for death beyond the classical variables with a hazard ratio (HR) = 2.19 95%CI = [1.29; 3.76] (p = 0.004), while TNC prognostic relation was tumor location-dependent with HR = 2.19 95%CI = [1.29; 3.76] (p = 0.004) in posterior fossa and HR = 0.64 [0.28; 1.48] (p = 0.295) in supratentorial (interaction p value = 0.015). The derived prognostic score identified 3 different robust risk groups. The omission of upfront RT was not associated with OS for good and intermediate prognostic groups while the absence of upfront RT was negatively associated with OS in the poor risk group.Integrated TNC expression and 1q25 status are useful to better stratify patients and to eventually adapt treatment regimens in pediatric intracranial ependymoma.

Published
2017
Full Text
View/download PDF

48. Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models.

Author

Estelle Daudigeos-Dubus, Ludivine Le Dret, Claudia Lanvers-Kaminsky, Olivia Bawa, Paule Opolon, Albane Vievard, Irène Villa, Mélanie Pagès, Jacques Bosq, Gilles Vassal, Dieter Zopf, and Birgit Geoerger

Subjects
Medicine, Science
Abstract

The multikinase inhibitor regorafenib (BAY 73-4506) exerts both anti-angiogenic and anti-tumorigenic activity in adult solid malignancies mainly advanced colorectal cancer and gastrointestinal stromal tumors. We intended to explore preclinically the potential of regorafenib against solid pediatric malignancies alone and in combination with anticancer agents to guide the pediatric development plan. In vitro effects on cell proliferation were screened against 33 solid tumor cell lines of the Innovative Therapies for Children with Cancer (ITCC) panel covering five pediatric solid malignancies. Regorafenib inhibited cell proliferation with a mean half maximal growth inhibition of 12.5 μmol/L (range 0.7 μmol/L to 28 μmol/L). In vivo, regorafenib was evaluated alone at 10 or 30 mg/kg/d or in combination with radiation, irinotecan or the mitogen-activated protein kinase kinase (MEK) inhibitor refametinib against various tumor types, including patient-derived brain tumor models with an amplified platelet-derived growth factor receptor A (PDGFRA) gene. Regorafenib alone significantly inhibited tumor growth in all xenografts derived from nervous system and connective tissue tumors. Enhanced effects were observed when regorafenib was combined with irradiation and irinotecan against PDGFRA amplified IGRG93 glioma and IGRM57 medulloblastoma respectively, resulting in 100% tumor regressions. Antitumor activity was associated with decreased tumor vascularization, inhibition of PDGFR signaling, and induction of apoptotic cell death. Our work demonstrates that regorafenib exhibits significant antitumor activity in a wide spectrum of preclinical pediatric models through inhibition of angiogenesis and induction of apoptosis. Furthermore, radio- and chemosensitizing effects were observed with DNA damaging agents in PDGFR amplified tumors.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results